JP5096238B2 - Liquid suction device - Google Patents
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Description
この発明は、試薬の有無を液センサで検出することができる液体吸引装置に関するものである。 The present invention relates to a liquid suction device capable of detecting the presence or absence of a reagent with a liquid sensor.
従来、試薬容器内の液量を検知するには、試薬を吸引したサンプリングノズルに光を照射し、透過した光の光学的な変化により、試薬の有無を検知する方法や、試薬を吸引したサンプリングノズル内に通電し、その抵抗値の変化により、試薬の有無を検知する方法や、試薬を吸引したサンプリングノズル内の温度変化や圧力変化等により、試薬の有無を検知する方法等が用いられている。 Conventionally, in order to detect the amount of liquid in a reagent container, a sampling nozzle that sucks the reagent is irradiated with light, and the presence or absence of the reagent is detected by optical change of the transmitted light. A method of detecting the presence or absence of a reagent based on a change in temperature or pressure in a sampling nozzle that sucks the reagent is used. Yes.
そして、特許文献１には、これらの方法を用いて、試薬容器内の液体を吸引する際に、流路内の定点を通過する液体の先端から終端までの通過時間を、予め求めておいた予測時間と比較することにより、前記試薬容器内の液量を測定する方法が開示されている。 And in patent document 1, when sucking the liquid in a reagent container using these methods, the passage time from the front end to the end of the liquid passing through a fixed point in the flow path was obtained in advance. A method for measuring the amount of liquid in the reagent container by comparing with an estimated time is disclosed.
しかしながら、特許文献１に記載の方法では、液体の種類によって粘度や密度等が異なると、液体の通過時間が変化し正確な試薬の液量が測定できないという問題がある。
しかし、分析に使用する試薬の液量は分析結果に大きく影響する。そのため分析に供する試薬液量の確認及び試薬切れの検知をすることは分析精度保障の上からも重要である。 However, the amount of reagent used for analysis greatly affects the analysis results. Therefore, confirmation of the amount of reagent solution to be used for analysis and detection of reagent shortage are important in terms of ensuring analysis accuracy.
そこで本発明は、容器内の試薬液量を正確に測定することが可能な液体吸引装置を提供すべく図ったものである。 Therefore, the present invention is intended to provide a liquid suction device capable of accurately measuring the amount of reagent solution in a container.
すなわち本発明に係る液体吸引装置は、一端が開口している流路と、前記流路上に設けられた液センサと、前記流路内に流体を吸引する吸引機構と、前記流路の開口端を上下に移動する駆動機構と、所定の容器内から所定量の流体を前記流路内に吸引した後、当該所定量の流体の前記流路内における末端部が前記液センサ内の検出位置に位置するような量の気体を前記流路内に吸引するように制御する制御部と、を備えていることを特徴とする。 That is, the liquid suction device according to the present invention includes a flow path having one end opened, a liquid sensor provided on the flow path, a suction mechanism that sucks fluid into the flow path, and an open end of the flow path. And a drive mechanism that moves the fluid up and down, and after a predetermined amount of fluid is sucked into the flow path from a predetermined container, the end of the predetermined amount of fluid in the flow path is at the detection position in the liquid sensor. And a control unit that controls the gas to be positioned so as to be sucked into the flow path.
このようなものであれば、前記容器内から試薬を所定量吸引した後、前記流路内に吸引した試薬の末端部が液センサ内の検出位置に位置するような量の空気を吸引することにより、前記容器内の試薬の有無や目的量の試薬をサンプリングできたかどうかの判定を行なうことができる。このため、本発明によれば、液体の粘度や密度等に影響されずに正確な試薬液量の確認及び試薬切れの検知を行なうことができる。 In such a case, after sucking a predetermined amount of reagent from the container, an amount of air is sucked such that the end of the reagent sucked into the flow path is located at the detection position in the liquid sensor. Thus, it is possible to determine whether or not there is a reagent in the container and whether or not a target amount of the reagent has been sampled. For this reason, according to the present invention, it is possible to accurately check the amount of the reagent solution and detect that the reagent has run out without being affected by the viscosity or density of the liquid.
前記流路内に吸引した試薬の末端部が液センサ内の検出位置に位置するような空気量の吸引は、１回で行なってもよいが、複数回に分割して行なってもよい。このように複数回に分割して吸引すれば、１回吸引するごとに流路内の検出位置における試薬の有無を検知するように液センサを作動させることにより、試薬中への気泡の混入を検出したり、吸引した試薬量を算出したりすることも可能となる。 The suction of the air amount so that the end of the reagent sucked into the flow path is located at the detection position in the liquid sensor may be performed once, or may be performed in a plurality of divided times. In this manner, if the liquid is divided into a plurality of times and aspirated once, the liquid sensor is operated so as to detect the presence or absence of the reagent at the detection position in the flow path every time the liquid is aspirated. It is also possible to detect or calculate the amount of aspirated reagent.
更に、一端が開口している流路と、前記流路上に設けられた液センサと、前記流路内に流体を吸引する吸引機構と、前記流路の開口端を上下に移動する駆動機構と、を備えている液体吸引装置を用いて、容器内の液体量を検知する方法であって、所定の容器内から所定量の流体を前記流路内に吸引した後、当該所定量の流体の前記流路内における末端部が前記液センサ内の検出位置に位置するような量の気体を前記流路内に吸引する液体検知方法もまた、本発明の１つである。 A flow path having one end opened; a liquid sensor provided on the flow path; a suction mechanism that sucks fluid into the flow path; and a drive mechanism that moves the open end of the flow path up and down. The method of detecting the amount of liquid in a container using a liquid suction device comprising: a suction of a predetermined amount of fluid from a predetermined container into the flow path; A liquid detection method for sucking an amount of gas into the flow path so that the end portion in the flow path is located at the detection position in the liquid sensor is also one aspect of the present invention.
このように本発明によれば、試薬液量の測定や試薬切れの検知を高い精度で行なうことができる。 As described above, according to the present invention, it is possible to measure the amount of the reagent solution and detect that the reagent has run out with high accuracy.
以下、本発明の一実施形態を、図面を参照して説明する。 Hereinafter, an embodiment of the present invention will be described with reference to the drawings.
本実施形態に係る液体吸引装置１は、図１及び図２に示すように、一端が開口していて、その開口端にはノズル２１が設けてある流路２と、流路２上に設けられた液センサ３と、流路３内に測定対象である試薬を吸引するための吸引機構４と、ノズル２１を保持するためのアーム６と、吸引機構４等を制御する情報処理装置５と、を備えている。 As shown in FIGS. 1 and 2, the liquid suction device 1 according to the present embodiment is provided on a flow path 2 having one end opened and a nozzle 21 provided at the open end, and the flow path 2. The liquid sensor 3, the suction mechanism 4 for sucking the reagent to be measured in the flow path 3, the arm 6 for holding the nozzle 21, the information processing apparatus 5 for controlling the suction mechanism 4 and the like, It is equipped with.
以下に各部を説明する。流路２は、光を透過する材質からなる管状体から構成され、その開口端にはノズル２１が設けてあるものであり、ノズル２１の先端開口部から流路２内に試薬Ｒを導入する。 Each part will be described below. The flow path 2 is composed of a tubular body made of a material that transmits light, and has an opening end provided with a nozzle 21, and introduces the reagent R into the flow path 2 from the tip opening of the nozzle 21. .
液センサ３は、図示しない光源と光検出器とを備えていて、検出位置Ｄにおいて、流路２に対して発光し、流路２を透過する光量を検出して、発光量と透過光量との差から流路２内の液体の有無を検出するものである。 The liquid sensor 3 includes a light source and a light detector (not shown), detects the amount of light emitted from the flow path 2 and transmitted through the flow path 2 at the detection position D, and determines the light emission amount and the transmitted light amount. The presence or absence of liquid in the flow path 2 is detected from the difference between the two.
吸引機構４は、流路３内に測定対象である試薬Ｒを吸引するためのものであり、例えば、シリンジ等からなるものである。 The suction mechanism 4 is for sucking the reagent R, which is a measurement object, into the flow path 3, and is composed of, for example, a syringe.
アーム６は、パルスモータ等の駆動源を備えていて、上下に移動可能にノズル２１を保持するものであり、試薬吸引時には、図１に示すように、ノゾル２１を下降させて容器Ｃ内に挿入し、空気吸引時には、図２に示すように、ノズル２１を上昇させて容器Ｃから引き上げるものである。 The arm 6 is provided with a drive source such as a pulse motor, and holds the nozzle 21 so as to be movable up and down. At the time of aspirating the reagent, the arm 21 is lowered to enter the container C as shown in FIG. At the time of insertion and air suction, the nozzle 21 is raised and pulled up from the container C as shown in FIG.
情報処理装置５は、ＣＰＵの他に、メモリ、キーボード等の入力手段、ディスプレイ等の出力手段等を備えた汎用乃至専用のものであり、メモリに所定のプログラムを格納し、当該プログラムに従ってＣＰＵやその周辺機器を協働動作させることによって、吸引制御部５１、液センサ制御部５２、アーム制御部５３、結果表示部５４等としての機能を発揮するように構成してある。 In addition to the CPU, the information processing device 5 is a general-purpose or dedicated device including an input unit such as a memory and a keyboard, an output unit such as a display, etc., stores a predetermined program in the memory, By operating the peripheral devices in cooperation, the functions as the suction control unit 51, the liquid sensor control unit 52, the arm control unit 53, the result display unit 54, and the like are exhibited.
吸引制御部５１は、容器Ｃ内から所定量の試薬Ｒを吸引した後、当該試薬Ｒの流路２内における末端部が液センサ３内の検出位置Ｄに位置するような量の空気を吸引するように、吸引機構４を制御するものである。 The suction controller 51 sucks a predetermined amount of the reagent R from the container C and then sucks an amount of air so that the end of the reagent R in the flow channel 2 is located at the detection position D in the liquid sensor 3. Thus, the suction mechanism 4 is controlled.
液センサ制御部５２は、吸引制御部５１と協動して、空気吸引後に、液センサ３内の検出位置Ｄにおける試薬Ｒの有無を検知するよう、液センサ３を制御するものである。 The liquid sensor control unit 52 controls the liquid sensor 3 so as to detect the presence or absence of the reagent R at the detection position D in the liquid sensor 3 after air suction in cooperation with the suction control unit 51.
アーム制御部５３は、吸引制御部５１と協動して、試薬吸引時には、図１に示すように、ノゾル２１を下降させて容器Ｃ内に挿入し、空気吸引時には、図２に示すように、ノズル２１を上昇させて容器Ｃから引き上げるように、アーム６を制御するものである。 The arm control unit 53 cooperates with the suction control unit 51 to lower the nozzle 21 and insert it into the container C as shown in FIG. 1 when aspirating the reagent, and as shown in FIG. The arm 6 is controlled so that the nozzle 21 is raised and pulled up from the container C.
結果表示部５４は、液センサ３で検出された検出位置Ｄにおける試薬Ｒの有無の結果を、文字、画像、音声等として出力するものである。 The result display unit 54 outputs the result of the presence or absence of the reagent R at the detection position D detected by the liquid sensor 3 as characters, images, sounds, and the like.
次に、液体吸引装置１を用いて容器Ｃ内から試薬Ｒを吸引してその有無を検知する手順を図３のフローチャートを参照して説明する。 Next, a procedure for aspirating the reagent R from the container C using the liquid suction device 1 and detecting the presence or absence will be described with reference to the flowchart of FIG.
まず、アーム制御部５３が制御信号を送信し、当該制御信号を受信したアーム６が、ノズル２１を下降させて、試薬Ｒが収容されている容器Ｃ内に挿入する（ステップＳ１）。 First, the arm controller 53 transmits a control signal, and the arm 6 that has received the control signal lowers the nozzle 21 and inserts it into the container C containing the reagent R (step S1).
次いで、吸引制御部５１が制御信号を送信し、当該制御信号を受信した吸引機構４がノズル２１から流路２内に所定量の試薬Ｒを吸引する（ステップＳ２）。 Next, the suction control unit 51 transmits a control signal, and the suction mechanism 4 that has received the control signal sucks a predetermined amount of the reagent R from the nozzle 21 into the flow path 2 (step S2).
続いて、アーム制御部５３が制御信号を送信し、当該制御信号を受信したアーム６が、ノズル２１を上昇させて、容器Ｃ内から引き上げる（ステップＳ３）。 Subsequently, the arm control unit 53 transmits a control signal, and the arm 6 receiving the control signal raises the nozzle 21 and pulls it up from the container C (step S3).
次に、吸引制御部５１が制御信号を送信し、当該制御信号を受信した吸引機構４がノズル２１から流路２内に所定量の空気を吸引する（ステップＳ４）。 Next, the suction control unit 51 transmits a control signal, and the suction mechanism 4 that has received the control signal sucks a predetermined amount of air from the nozzle 21 into the flow path 2 (step S4).
そして、液センサ制御部５２が制御信号を送信し、当該制御信号を受信した液センサ３が、光源から流路２に光を発し、流路２を透過する光量を検出して、発光量と透過光量との差から、検出位置Ｄにおける流路２内の試薬Ｒの有無を検出する（ステップＳ５）。 Then, the liquid sensor control unit 52 transmits a control signal, and the liquid sensor 3 that has received the control signal emits light from the light source to the flow path 2, detects the amount of light transmitted through the flow path 2, The presence or absence of the reagent R in the flow path 2 at the detection position D is detected from the difference from the transmitted light amount (step S5).
このとき、容器Ｃ内に所定量以上の試薬Ｒがあれば、図４（ａ）に示すように、流路２内に吸引した試薬Ｒの末端部が液センサ３内の検出位置Ｄに位置し、所定量の試薬Ｒが吸引されたことが検知される。一方、容器Ｃ内に所定量未満の試薬Ｒしかないと、試薬Ｒが足りなかった分だけ空気Ａが吸引されるので、図４（ｂ）に示すように、液センサ３内の検出位置Ｄには空気Ａが存在して、試薬Ｒが所定量未満しかなかったことが検知される。 At this time, if there is a predetermined amount or more of the reagent R in the container C, the end of the reagent R sucked into the flow channel 2 is positioned at the detection position D in the liquid sensor 3 as shown in FIG. Then, it is detected that a predetermined amount of reagent R has been aspirated. On the other hand, if there is only a reagent R less than a predetermined amount in the container C, the air A is sucked as much as the reagent R is insufficient, so that the detection position D in the liquid sensor 3 as shown in FIG. It is detected that air A is present and the reagent R is less than a predetermined amount.
最後に、結果表示部５４が液センサ３から検出結果を取得して、文字、画像、音声等として出力する（ステップＳ６）。 Finally, the result display unit 54 acquires the detection result from the liquid sensor 3 and outputs it as characters, images, sounds, etc. (step S6).
したがって、このように構成した液体吸引装置１によれば、容器Ｃ内から流路２内に所定量の試薬Ｒを吸引した後、引き続いて吸引する空気の量を、先に流路２内に吸引した所定量の試薬Ｒの末端部が液センサ３内の検出位置Ｄに位置するように設定してあるので、容器Ｃ内の試薬Ｒの有無や目的量の試薬Ｒをサンプリングできたかどうかの判定を、試薬Ｒの粘度や密度等に影響されずに正確に行なうことができる。 Therefore, according to the liquid suction device 1 configured as described above, after sucking a predetermined amount of the reagent R from the container C into the flow channel 2, the amount of air to be subsequently sucked into the flow channel 2 first is reduced. Since the end portion of the aspirated predetermined amount of the reagent R is set to be located at the detection position D in the liquid sensor 3, the presence or absence of the reagent R in the container C and whether the target amount of the reagent R has been sampled can be determined. The determination can be made accurately without being affected by the viscosity, density, etc. of the reagent R.
なお、吸引試薬量の変化には、流路２内における検出位置Ｄの位置（液センサ３設置位置）や、吸引機構４のストローク量を調節する等して吸引空気量の設定を変えることにより、対応することができる。 In order to change the amount of the aspirating reagent, the setting of the aspirating air amount is changed by adjusting the position of the detection position D (position where the liquid sensor 3 is installed) in the flow path 2 or the stroke amount of the aspirating mechanism 4. Can respond.
また、複数種類の試薬からなるキットに関しては、最初に消費される試薬の有無を液体吸引装置１で検知することにより、キットの交換時期を知ることができる。 In addition, for a kit composed of a plurality of types of reagents, the liquid aspirator 1 detects the presence or absence of a reagent that is consumed first, thereby knowing the replacement time of the kit.
なお、本発明は前記実施形態に限られるものではない。 The present invention is not limited to the above embodiment.
例えば、液センサ制御部５２の設定を変えて、試薬吸引後に空気を吸引するときの吸引機構４の１ストロークをＮ回に分割し、１回ごとに流路２内の検出位置Ｄにおける試薬Ｒの有無を検知するように液センサ３を作動させれば、気泡の混入を検出したり、吸引した試薬量を算出したりすることも可能となる。 For example, the setting of the liquid sensor control unit 52 is changed to divide one stroke of the suction mechanism 4 when the air is sucked after the reagent is sucked into N times, and the reagent R at the detection position D in the flow path 2 every time. If the liquid sensor 3 is operated so as to detect the presence or absence of bubbles, it is possible to detect the mixing of bubbles or calculate the amount of aspirated reagent.
液センサ３は、光学的センサに限定されず、流路２内の液体の有無を識別できれば電磁式センサや超音波センサ等であってもよく、この場合、液センサ３は流路２に固定されなくてもよく、流路２を構成する管状体の材質も光透過性のものに限定されない。 The liquid sensor 3 is not limited to an optical sensor, and may be an electromagnetic sensor, an ultrasonic sensor, or the like as long as the presence or absence of liquid in the flow path 2 can be identified. In this case, the liquid sensor 3 is fixed to the flow path 2. The material of the tubular body constituting the flow path 2 is not limited to the light transmissive one.
本発明は、その他、前述した実施形態や変形実施形態の一部又は全部を適宜組み合わせてもよく、その趣旨を逸脱しない範囲で種々の変形が可能であるのは言うまでもない。 It goes without saying that the present invention may appropriately combine some or all of the above-described embodiments and modified embodiments, and various modifications can be made without departing from the spirit of the present invention.
１・・・液体吸引装置
２・・・流路
３・・・液センサ
４・・・吸引機構
５１・・・吸引制御部
５２・・・液センサ制御部
５３・・・アーム制御部
DESCRIPTION OF SYMBOLS 1 ... Liquid suction apparatus 2 ... Flow path 3 ... Liquid sensor 4 ... Suction mechanism 51 ... Suction control part 52 ... Liquid sensor control part 53 ... Arm control part
Claims (3)
前記流路上に設けられた液センサと、
前記流路内に流体を吸引する吸引機構と、
前記流路の開口端を上下に移動する駆動機構と、
所定の容器内から予め設定した所定量の流体を前記流路内に吸引した後、当該流体が所定量吸引されたならばその末端部が前記液センサ内の検出位置に位置するように予め設定した量の気体を前記流路内に吸引するように制御する制御部と、を備えており、
前記液センサが、前記気体の吸引後に前記検出位置における流路内の流体の有無を検出する液体吸引装置。 A channel having one open end;
A liquid sensor provided on the flow path;
A suction mechanism for sucking fluid into the flow path;
A drive mechanism for moving the open end of the flow path up and down;
After aspirating a predetermined amount of fluid has been set in advance from a given vessel the flow channel, preset to its distal end, if the fluid is predetermined suction amount is located at the detection position of the liquid within the sensor A control unit that controls to suck the amount of gas into the flow path,
The liquid suction device , wherein the liquid sensor detects the presence or absence of fluid in the flow path at the detection position after the gas is sucked .
所定の容器内から予め設定した所定量の流体を前記流路内に吸引した後、当該流体が所定量吸引されたならばその末端部が前記液センサ内の検出位置に位置するように予め設定した量の気体を前記流路内に吸引し、前記検出位置における流路内の流体の有無を検出する液体検知方法。
A flow path having one end open, a liquid sensor provided on the flow path, a suction mechanism for sucking fluid into the flow path, and a drive mechanism for moving the open end of the flow path up and down. A method for detecting the amount of liquid in a container using a liquid suction device provided,
After aspirating a predetermined amount of fluid has been set in advance from a given vessel the flow channel, preset to its distal end, if the fluid is predetermined suction amount is located at the detection position of the liquid within the sensor A liquid detection method for sucking the amount of gas into the flow path and detecting the presence or absence of fluid in the flow path at the detection position .
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008158979A JP5096238B2 (en) | 2008-06-18 | 2008-06-18 | Liquid suction device |
| EP09007212.5A EP2136210B1 (en) | 2008-06-18 | 2009-05-29 | Body fluid sample analyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008158979A JP5096238B2 (en) | 2008-06-18 | 2008-06-18 | Liquid suction device |
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| Publication Number | Publication Date |
|---|---|
| JP2010002201A JP2010002201A (en) | 2010-01-07 |
| JP5096238B2 true JP5096238B2 (en) | 2012-12-12 |
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| JP2008158979A Expired - Fee Related JP5096238B2 (en) | 2008-06-18 | 2008-06-18 | Liquid suction device |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6220575B2 (en) * | 2013-06-27 | 2017-10-25 | シスメックス株式会社 | Sample processing apparatus and abnormality detection method for sample processing apparatus |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2592837B2 (en) * | 1987-04-25 | 1997-03-19 | 株式会社東芝 | Automatic chemical analyzer |
| JPH02135865U (en) * | 1989-03-23 | 1990-11-13 | ||
| JP3043510B2 (en) * | 1992-02-05 | 2000-05-22 | シスメックス株式会社 | Sample stirring suction device |
| JP3317530B2 (en) * | 1992-11-04 | 2002-08-26 | プレシジョン・システム・サイエンス株式会社 | Dispensing method and dispensing device |
| JPH06174731A (en) * | 1992-12-01 | 1994-06-24 | Toshiba Corp | Automatic analyzer |
| JPH0815273A (en) * | 1994-06-30 | 1996-01-19 | Shimadzu Corp | Automatic chemical analyzer |
| US6250130B1 (en) * | 1995-07-10 | 2001-06-26 | Bayer Corporation | Method and apparatus for monitoring an aspirating and dispensing system |
| JP2816117B2 (en) * | 1995-08-08 | 1998-10-27 | 株式会社東芝 | Automatic chemical analyzer |
| JP3907819B2 (en) * | 1998-03-23 | 2007-04-18 | オリンパス株式会社 | Liquid level detector |
| JP3401504B2 (en) * | 2002-02-15 | 2003-04-28 | プレシジョン・システム・サイエンス株式会社 | Dispensing device |
| JP2004333439A (en) * | 2003-05-12 | 2004-11-25 | Hitachi High-Technologies Corp | Method and instrument for measuring liquid volume |
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