JP5057990B2 - 線維筋痛症候群の治療のためのアセチルl−カルニチンの使用 - Google Patents
線維筋痛症候群の治療のためのアセチルl−カルニチンの使用 Download PDFInfo
- Publication number
- JP5057990B2 JP5057990B2 JP2007544754A JP2007544754A JP5057990B2 JP 5057990 B2 JP5057990 B2 JP 5057990B2 JP 2007544754 A JP2007544754 A JP 2007544754A JP 2007544754 A JP2007544754 A JP 2007544754A JP 5057990 B2 JP5057990 B2 JP 5057990B2
- Authority
- JP
- Japan
- Prior art keywords
- acid
- carnitine
- acetyl
- treatment
- fibromyalgia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Description
-軸骨格における両側瀰漫性疼痛;
-上肢における両側瀰漫性疼痛;
-下肢における両側瀰漫性疼痛;
-標準化圧力手法(pressure manoeuvre)によって誘発した圧痛点(ACR 圧痛点)の地図において列挙した18の解剖学的領域のうち11以上に位置する疼痛。
-骨関節または被蓋野(tegumental apparatus)に影響を及ぼす感染症または炎症工程の存在;
-試験処置の評価を混乱させうる臨床的に重要な骨関節疾患の病歴または存在(例えば、外傷の病歴);
-以前の整形外科手術、脊椎関節症(spondyloarthrosis)、結合組織炎(connectivitis)等;
-臨床または検査室での甲状腺機能低下症の証拠;
-全身性疾患(糖尿病、腎疾患、心血管疾患および呼吸器疾患、精神病)または試験処置の評価に干渉しうる主な病的状態の存在;
-試験前の3ヶ月の間の抗炎症性ステロイド薬の継続使用;
-エストロゲン-プロゲストーゲンホルモン補充療法の最近の開始(1年未満);
-試験前の6ヶ月の間の抗うつ薬による治療;
-試験前の3日の間の非ステロイド性抗炎症薬による治療;
-試験前の7日の間の鎮痛薬による治療;
-以前6ヶ月の間の臨床試験への参加;
-妊婦、授乳中の女性、または適切な避妊法を行っていない出産可能年齢の女性。
Claims (2)
- アセチル L-カルニチンまたはその医薬上許容される塩のいずれかを含む、線維筋痛症の治療のための医薬。
- アセチル L-カルニチンの医薬上許容される塩が、塩化物、臭化物、オロチン酸塩、アスパラギン酸塩、酸アスパラギン酸塩、クエン酸塩、酸クエン酸塩、マグネシウムクエン酸塩、リン酸塩、酸リン酸塩、フマル酸塩、酸フマル酸塩、 マグネシウムフマル酸塩、グリセロリン酸塩、乳酸塩、マレイン酸塩および酸マレイン酸塩、ムケート、シュウ酸塩、酸シュウ酸塩、パモ酸塩、酸パモ酸塩、硫酸塩、酸硫酸塩、グルコースリン酸塩、酒石酸塩、酸酒石酸塩、マグネシウム酒石酸塩、2-アミノエタンスルホン酸塩、マグネシウム 2-アミノエタンスルホン酸塩、メタンスルホン酸塩、コリン酒石酸塩、トリクロロ酢酸塩、およびトリフルオロ酢酸塩からなる群から選択される、請求項 1の医薬。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM2004A000606 | 2004-12-13 | ||
IT000606A ITRM20040606A1 (it) | 2004-12-13 | 2004-12-13 | Uso della acetil l-carnitina per il trattamento della sindrome fibromialgica. |
PCT/EP2005/012054 WO2006063639A1 (en) | 2004-12-13 | 2005-11-10 | Use of acetyl l-carnitine for the treatment of fibromyalgic syndrome |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2008534433A JP2008534433A (ja) | 2008-08-28 |
JP2008534433A5 JP2008534433A5 (ja) | 2008-12-25 |
JP5057990B2 true JP5057990B2 (ja) | 2012-10-24 |
Family
ID=35708966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007544754A Expired - Fee Related JP5057990B2 (ja) | 2004-12-13 | 2005-11-10 | 線維筋痛症候群の治療のためのアセチルl−カルニチンの使用 |
Country Status (16)
Country | Link |
---|---|
US (1) | US8013016B2 (ja) |
EP (1) | EP1824472B1 (ja) |
JP (1) | JP5057990B2 (ja) |
KR (1) | KR101240182B1 (ja) |
AT (1) | ATE419847T1 (ja) |
CA (1) | CA2585560C (ja) |
CY (1) | CY1110576T1 (ja) |
DE (1) | DE602005012317D1 (ja) |
DK (1) | DK1824472T3 (ja) |
ES (1) | ES2320788T3 (ja) |
IT (1) | ITRM20040606A1 (ja) |
MX (1) | MX2007006954A (ja) |
PL (1) | PL1824472T3 (ja) |
PT (1) | PT1824472E (ja) |
SI (1) | SI1824472T1 (ja) |
WO (1) | WO2006063639A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012178014A1 (en) * | 2011-06-24 | 2012-12-27 | K-Pax Pharmaceuticals, Inc. | Compositions and methods for treatment of chronic fatigue |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1150396B (it) * | 1982-12-09 | 1986-12-10 | Sigma Tau Ind Farmaceuti | Impiego di alcanoil l-carnitine per il trattamento terapeutico di miopa tie e distrofie muscolari |
EP0681839A3 (en) * | 1994-05-12 | 1997-11-12 | Hirohiko Kuratsune | A pharmaceutical preparation comprising an acylcarnitine |
US6025368A (en) * | 1997-02-25 | 2000-02-15 | Celtrix Pharmaceuticals, Inc. | Method for treating the symptoms of chronic stress-related disorders using IGF |
US5935949A (en) * | 1998-03-20 | 1999-08-10 | Trustees Of Dartmouth College | Use of androgen therapy in fibromyalgia and chronic fatigue syndrome |
US6803387B1 (en) | 1999-03-19 | 2004-10-12 | Abbott Gmbh & Co. Kg | Treatment of neuropathic pain or fibromyalgia |
ITRM20010293A1 (it) | 2001-05-29 | 2002-11-29 | Sigma Tau Ind Farmaceuti | Uso della acetil-l-carnetina per la preparazione di un medicamento per la prevenzione del dolore. |
EP1507765A4 (en) * | 2002-05-03 | 2006-11-02 | Israel Inst Biolog Res | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM AND PERIPHERAL NERVOUS SYSTEM DISORDERS AND RELATED COMPOUNDS |
-
2004
- 2004-12-13 IT IT000606A patent/ITRM20040606A1/it unknown
-
2005
- 2005-11-10 US US11/719,447 patent/US8013016B2/en not_active Expired - Fee Related
- 2005-11-10 ES ES05807584T patent/ES2320788T3/es active Active
- 2005-11-10 DK DK05807584T patent/DK1824472T3/da active
- 2005-11-10 SI SI200530579T patent/SI1824472T1/sl unknown
- 2005-11-10 KR KR1020077015272A patent/KR101240182B1/ko not_active IP Right Cessation
- 2005-11-10 WO PCT/EP2005/012054 patent/WO2006063639A1/en active Application Filing
- 2005-11-10 MX MX2007006954A patent/MX2007006954A/es active IP Right Grant
- 2005-11-10 DE DE602005012317T patent/DE602005012317D1/de active Active
- 2005-11-10 EP EP05807584A patent/EP1824472B1/en not_active Not-in-force
- 2005-11-10 PT PT05807584T patent/PT1824472E/pt unknown
- 2005-11-10 AT AT05807584T patent/ATE419847T1/de active
- 2005-11-10 CA CA2585560A patent/CA2585560C/en not_active Expired - Fee Related
- 2005-11-10 JP JP2007544754A patent/JP5057990B2/ja not_active Expired - Fee Related
- 2005-11-10 PL PL05807584T patent/PL1824472T3/pl unknown
-
2009
- 2009-03-31 CY CY20091100383T patent/CY1110576T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1824472A1 (en) | 2007-08-29 |
DK1824472T3 (da) | 2009-03-30 |
ES2320788T3 (es) | 2009-05-28 |
ATE419847T1 (de) | 2009-01-15 |
WO2006063639A1 (en) | 2006-06-22 |
US20090076146A1 (en) | 2009-03-19 |
JP2008534433A (ja) | 2008-08-28 |
SI1824472T1 (sl) | 2009-04-30 |
KR101240182B1 (ko) | 2013-03-07 |
CY1110576T1 (el) | 2015-04-29 |
CA2585560A1 (en) | 2006-06-22 |
CA2585560C (en) | 2013-01-08 |
KR20070091317A (ko) | 2007-09-10 |
PL1824472T3 (pl) | 2009-05-29 |
US8013016B2 (en) | 2011-09-06 |
DE602005012317D1 (de) | 2009-02-26 |
ITRM20040606A1 (it) | 2005-03-13 |
PT1824472E (pt) | 2009-03-31 |
MX2007006954A (es) | 2007-08-02 |
EP1824472B1 (en) | 2009-01-07 |
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