JP5053519B2 - 植物性トリプシン阻害剤 - Google Patents
植物性トリプシン阻害剤 Download PDFInfo
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- JP5053519B2 JP5053519B2 JP2005099907A JP2005099907A JP5053519B2 JP 5053519 B2 JP5053519 B2 JP 5053519B2 JP 2005099907 A JP2005099907 A JP 2005099907A JP 2005099907 A JP2005099907 A JP 2005099907A JP 5053519 B2 JP5053519 B2 JP 5053519B2
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- 238000003811 acetone extraction Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229960000271 arbutin Drugs 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000008278 cosmetic cream Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- YVIGPQSYEAOLAD-UHFFFAOYSA-L disodium;dodecyl phosphate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOP([O-])([O-])=O YVIGPQSYEAOLAD-UHFFFAOYSA-L 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000020765 fenugreek extract Nutrition 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 239000000453 juniperus communis l. leaf oil Substances 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 229940074358 magnesium ascorbate Drugs 0.000 description 1
- AIOKQVJVNPDJKA-ZZMNMWMASA-L magnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2h-furan-3-olate Chemical compound [Mg+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] AIOKQVJVNPDJKA-ZZMNMWMASA-L 0.000 description 1
- 239000010445 mica Substances 0.000 description 1
- 229910052618 mica group Inorganic materials 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 230000003169 placental effect Effects 0.000 description 1
- 229940012957 plasmin Drugs 0.000 description 1
- PYJBVGYZXWPIKK-UHFFFAOYSA-M potassium;tetradecanoate Chemical compound [K+].CCCCCCCCCCCCCC([O-])=O PYJBVGYZXWPIKK-UHFFFAOYSA-M 0.000 description 1
- 235000020236 pumpkin seed Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 235000020712 soy bean extract Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
- 239000009538 yokuinin Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
pluriflorum(Miq.)Ohwi)、ヒメイズイ(P. humile Fisch.)、ナルコユリ(P.
falcatum A. Gray)が、ネギ属植物としてはニラ(Allium
tuberosum ROTLER)が、マメ科クララ属植物としてはクララ(Sophora flavescens Aiton)、エンジュ(S. japonica L.)イソフジ(S.
tomentosa L.が)、クズ属植物としてはクズ(Pueraria
lobata (Willd.)ohwi)が、ダイズ属植物としてはダイズ(Glycine max Merr.)、ツルマメ(G.soja Siebold et Zucc.)が、フジ属植物としてはノダフジ(Wistaria Floribunda(Willd.)DC.)、ヤマフジ(W.brachybotrys Siebold et Zucc.)が、フォエヌム・グラエクム属としてはコロハ(Trigonella foenum−graecum L.)が、ウリ科カボチャ属植物としてはカボチャ(Cucurbita moschata(Duchesne)Poir. var. meloniformis(Carriere)Makino)、セイヨウカボチャ(C. pepo L.)が、ニガウリ属植物としてはツルレイシ(Momordica charantia L.)(別名ニガウリ)が、ヘチマ属植物としてはヘチマ(Luffa aegyptiaca Mill.)が、タデ科ソバ属植物としてはソバ(Fagopyrum esculentum Moench)、(F.dibotrys(D.Don)H.Hara)が、セリ科ウイキョウ属植物としてはウイキョウ(Foeniculum vulgare Mill.)、アブラナ科アルバ属植物としてはシロガラシ(Sinapis alba L.)が利用できる。
〔試 薬〕
リン酸緩衝液 :0.1M−NaH2PO4と0.1M−Na2HPO4を5:25で混ぜPH7.4に調製する。
基質溶液 :カゼイン(Hammerstein Cazein)0.6gを0.05M−Na2HPO4 80mlに
加え、沸騰水浴中で加熱溶解させる。冷却後、PHを7.4に調製する。
トリプシン溶液:1:250トリプシン(DIFCO)を10μg/mlになるようにリン酸緩衝液に溶解
する。
沈澱試薬 :トリクロル酢酸、酢酸Na、酢酸溶液を、それぞれ0.11M、0.22M、0.33M
濃度になるように溶液を調製する。
試料溶液 :所定の濃度になるように水またはエタノールを加え調製する。
〔測 定〕
カゼイン基質溶液0.9mlに試料溶液0.1mlを加え混合する。さらに、トリプシン溶液2ml
を加え撹拌し、37℃で10分間放置する。沈澱試薬3ml加えよく撹拌し、室温で15分間放置する。その後3.000rpm、15分間遠心し、上澄み液をとり280nmの吸光度を測定する。
〔阻害率の測定〕
阻害率の算定は式1により求める。
コントロール(C):トリプシン溶液を沈澱試薬の後に添加する。
対照(T):試料の代わりに蒸留水を用いたもの。
試験区(S):各試料を用いて上記の操作を行ったもの。
(重量%)
a)ミツロウ
2.0
b)ステアリルアルコール
5.0
c)ステアリン酸
8.0
d)スクワラン
10.0
e)自己乳化型グリセリルモノステアレート
3.0
f)ポリオキシエチレンセチルエーテル(20E.O.)
1.0
g)ホホバ油 10.0
h)ヘチマ抽出物
0.5
i)アスコルビン酸グルコシド 2.0
j)1,3-ブチレングリコール
5.0
k)水酸化カリウム
0.3
l)防腐剤・酸化防止剤
適量
m)精製水
残部
製法 a)〜f)までを加熱溶解し、80℃に保つ。H)〜m)までを加熱溶解し、80℃に保ち、a)〜f)に加えて乳化し、40℃まで撹拌しながら冷却する。その後、g)を加え、攪拌し均一に溶解する。
(重量%)
a)ミツロウ
0.5
b)ワセリン
2.0
c)スクワラン
8.0
d)ソルビタンセスキオレエート
0.8
e)ポリオキシエチレンオレイルエーテル(20E.O.) 1.2
f)クズ抽出物
1.0
g)アルブチン
2.0
h)1,3-ブチレングリコール
7.0
i)カルボキシビニルポリマー
0.2
j)水酸化カリウム
0.1
k)精製水
残部
l)防腐剤・酸化防止剤
適量
m)エタノール
7.0
製法 a)〜e)までを加熱溶解し、80℃に保つ。h)〜l)までを加熱溶解し、80℃に保ち、a)〜e)に加えて乳化し、50℃まで撹拌しながら冷却する。50℃でf)、g)、m)を添加し、40℃まで攪拌、冷却する。
(重量%)
a)ソバ抽出物
0.1
b)アスコルビン酸リン酸マグネシウム
1.0
c)グリセリン
5.0
d)ポリオキシエチレンソルビタンモノラウレート(20E.O.) 1.0
e)エタノール
6.0
f)香料 適量
g)防腐剤・酸化防止剤
適量
h)精製水
残部
製法 a)とb)を均一に混合する。c)〜h)までを混合し、均一に溶解する。使用時に2剤を混合して使用する。
(重量%)
a)コロハ抽出物 0.05
b)グルタチオン 0.1
c)グリセリン
5.0
d)ポリオキシエチレンソルビタンモノラウレート(20E.O.)
1.0
e)エタノール
6.0
f)香料 適量
g)防腐剤・酸化防止剤
適量
h)精製水
残部
製法 a)〜b)までを混合する。c)〜h)までを混合し、均一に溶解する。使用時に2剤を混合して使用する。
(重量%)
a)ダイズ抽出物
0.5
b)アスコルビン酸グルコシド
2.0
c)シャクヤク抽出液 0.5
d)タルク
残部
e)セルロース
20.0
f)ミリスチン酸カリウム 30.0
g)ラウリルリン酸ナトリウム
10.0
h)香料
適量
i)防腐剤
適量
製法 a)〜i)までを混合し、よく撹拌、分散させ均一にする。
(1)塗布によるヒトでの効果確認試験
被験者として、25〜55歳の女性20名に1日2回(朝、夜)連続2.5ヵ月間、本発明品と比較品のそれぞれを使用させ、塗布部位の状態を試験前後で比較し、改善効果を調べた。本試験には、試験品として0029で示した化粧料を用い、対照品 1 には0029に示した化粧料からヘチマ抽出物を除いた化粧料、対照品 2 には0029に示した化粧料からアスコルビン酸グルコシドを除いた化粧料を作成し、その使用による効果について調べた。そして、本発明の有効成分を配合した化粧料を毎日使用しながら肌のクスミおよび美白効果を塗布開始前及び2ヶ月塗布後におけるアンケートで集計し、効果の確認を行った。その結果を表-2に示す。
Claims (1)
- ユリ科アマドコロ属植物がアマドコロ(Polygonatum odoratum(Mill.)Druce var. pluriflorum(Miq.)Ohwi)、ヒメイズイ(P. humile Fisch.)、ネギ属植物がニラ(Allium tuberosum ROTLER)、マメ科クララ属植物がクララ(Sophora flavescens Aiton)、エンジュ(S. japonica L.)、イソフジ(S. tomentosa
L.)、クズ属植物がクズ(Pueraria lobata (Willd.)ohwi)、フジ属がノダフジ(Wistaria Floribunda(Willd.)DC.)、ヤマフジ(W.brachybotrys Siebold et Zucc.)、フォエヌム・グラエクム属がコロハ(Trigonella foenum−graecum L.)、ウリ科カボチャ属がカボチャ(Cucurbita moschata(Duchesne)Poir. var. meloniformis(Carriere)Makino)、セイヨウカボチャ(C.pepo L.)、ニガウリ属がツルレイシ(Momordicacharantia L.)(別名ニガウリ)、タデ科ソバ属がソバ(Fagopyrum esculentum Moench)、(F.dibotrys(D.Don)H.Hara)から選ばれる1種又は2種以上の除タンパクをした抽出物からなるセリンプロテアーゼ阻害剤。
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JP4452203B2 (ja) * | 2005-03-30 | 2010-04-21 | 株式会社ナリス化粧品 | 美白化粧料 |
JP5010879B2 (ja) * | 2006-09-07 | 2012-08-29 | 常盤薬品工業株式会社 | 液剤組成物 |
JP5116328B2 (ja) * | 2007-03-22 | 2013-01-09 | 株式会社ノエビア | 皮膚外用剤及び飲食品 |
JP2010536891A (ja) * | 2007-08-27 | 2010-12-02 | ディーエスエム アイピー アセッツ ビー.ブイ. | トリプターゼ阻害性マスタード抽出物 |
JP5275779B2 (ja) * | 2008-03-19 | 2013-08-28 | 株式会社コーセー | 美白剤及び皮膚外用剤 |
JP2011068576A (ja) * | 2009-09-24 | 2011-04-07 | Pola Chemical Industries Inc | 美白用の皮膚外用剤 |
JP2011079768A (ja) * | 2009-10-06 | 2011-04-21 | National Institute Of Advanced Industrial Science & Technology | メラニン生成系の生体内物質を阻害する薬剤 |
US9421236B2 (en) | 2010-12-17 | 2016-08-23 | Johnson & Johnson Consumer Inc. | Compositions comprising Lilium siberia extracts and uses thereof |
US8481093B2 (en) | 2010-12-17 | 2013-07-09 | Johnson & Johnson Consumer Companies, Inc. | Compositions comprising Lilium candidum extracts and uses thereof |
CN102579296B (zh) * | 2012-03-14 | 2013-10-16 | 上海应用技术学院 | 一种含苦瓜提取物的防晒组合物及其应用 |
JP6595192B2 (ja) * | 2014-02-25 | 2019-10-23 | 日本メナード化粧品株式会社 | 特定の波長域を有する光を照射して栽培したフェヌグリークの抽出物を含有する皮膚外用剤や内用剤。 |
JP6338107B2 (ja) * | 2014-09-30 | 2018-06-06 | 株式会社東洋新薬 | 皮膚バリア機能改善剤、細胞間接着構造の形成促進剤、タイトジャンクション形成促進剤及びtrpv4遺伝子の発現亢進剤 |
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CN108181370A (zh) * | 2018-01-08 | 2018-06-19 | 太原科技大学 | 槐角胰蛋白酶抑制剂的制备、活性测定及抑制常数测定的方法 |
CN112807254A (zh) * | 2020-03-23 | 2021-05-18 | 上海铮信生物科技有限公司 | 皮肤修复组合物及其在化妆品中的应用 |
CN111388367B (zh) * | 2020-03-25 | 2021-09-24 | 江南大学 | 一种多靶点抑制黑色素的组合物和制备方法及其在化妆品中的应用 |
CN112021304A (zh) * | 2020-09-17 | 2020-12-04 | 山东省齐鲁干细胞工程有限公司 | 一种脐带间充质干细胞的冻存方法及复苏方法 |
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JP4091824B2 (ja) * | 2002-02-05 | 2008-05-28 | 株式会社コーセー | 皮膚外用剤 |
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