JP5049032B2 - Vacuum stopper jig - Google Patents

Vacuum stopper jig Download PDF

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JP5049032B2
JP5049032B2 JP2007050068A JP2007050068A JP5049032B2 JP 5049032 B2 JP5049032 B2 JP 5049032B2 JP 2007050068 A JP2007050068 A JP 2007050068A JP 2007050068 A JP2007050068 A JP 2007050068A JP 5049032 B2 JP5049032 B2 JP 5049032B2
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outer cylinder
jig
stopper
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JP2008212213A (en
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順一 久保
隆明 義永
一則 牟田
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Hisamitsu Pharmaceutical Co Inc
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本発明は、シリンジ外筒内に栓体を装填させるための真空打栓用治具に関するものである。   The present invention relates to a vacuum stopper jig for loading a stopper in a syringe outer cylinder.

従来、このような分野の技術として、特開２００５−２０４６７８号公報がある。この公報に記載された真空打栓用治具の治具本体内には、栓体を保持するための凹部が設けられ、この凹部を形成する壁面には、長手方向に延在する隙間が設けられている。また、治部本体の頂部には、押圧部材(打栓棒)が挿入される開口が形成されている。このような治具を用いてシリンジ外筒に栓をする手順として、先ず、治具本体の凹部内に栓体(外栓)を収容した状態で、治具本体の先端を、シリンジ外筒に設けられた指掛け部に圧着させる。その後、治具本体に形成された通気孔からシリンジ外筒内の脱気を行う。その後、通気孔からシリンジ外筒内に窒素を充填し、そして、その窒素を通気孔から脱気する。その後、押圧部材によって栓体を押しながらシリンジ外筒の基端に栓体を嵌め込む。   Conventionally, as a technology in such a field, there is JP-A-2005-204678. In the jig body of the vacuum plugging jig described in this publication, a recess for holding the stopper is provided, and a wall extending in the longitudinal direction is provided on the wall surface forming the recess. It has been. In addition, an opening into which a pressing member (plugging rod) is inserted is formed at the top of the treatment body. As a procedure for plugging the syringe outer cylinder using such a jig, first, with the stopper (outer plug) accommodated in the recess of the jig main body, the tip of the jig main body is attached to the syringe outer cylinder. Crimp to the provided finger rest. Then, the inside of a syringe outer cylinder is deaerated from the vent hole formed in the jig body. Thereafter, the syringe outer cylinder is filled with nitrogen from the vent hole, and the nitrogen is degassed from the vent hole. Thereafter, the stopper is fitted into the proximal end of the syringe outer cylinder while pressing the stopper with the pressing member.

特開２００５−２０４６７８号公報JP 2005-204678 A 特開平７−１２４２３０号公報JP-A-7-124230 特公平４−２８３８６号公報Japanese Patent Publication No. 4-28386 特開２００５−１３１２１６号公報JP 2005-131216 A

しかしながら、真空打栓時に栓体を保持するための従来の真空打栓用治具は、シリンジ外筒の基端側の開口と治具に保持された栓体との位置合わせを、別の治具で行わなければならないので、真空打栓装置の構成を複雑にし、しかも、真空打栓時における治具とシリンジ外筒の基端側の開口との位置ズレは、栓体をシリンジ外筒内に確実に挿入させ難くし、栓体の無理な押込みによって、シリンジ外筒内で栓体が傾いた状態で装填されることになるので、栓体の気密及び水密性能の低下を招来する虞があった。   However, the conventional vacuum stopper jig for holding the stopper when vacuum stoppering is used for the positioning of the opening of the proximal end of the syringe outer cylinder and the stopper held by the jig in another jig. Therefore, the configuration of the vacuum stopper is complicated, and the position of the jig and the opening on the proximal end side of the syringe outer cylinder during vacuum stopper is different. Since the plug body is loaded in an inclined state in the syringe outer cylinder due to the forced push-in of the plug body, there is a risk of causing deterioration of the airtightness and watertight performance of the plug body. there were.

本発明は、特に、簡単な構成をもって、栓体をシリンジ外筒内に確実に挿入させるようにした真空打栓用治具を提供することを目的とする。   It is an object of the present invention to provide a vacuum plugging jig having a simple configuration that allows a stopper to be reliably inserted into a syringe outer cylinder.

本発明に係る真空打栓用治具は、シリンジ外筒内を減圧させてシリンジ外筒内に断面円形の栓体を装填させるために、シリンジ外筒に設けられた指掛け部に当接させて利用される真空打栓用治具であって、
フランジ状の指掛け部を収容する指掛け収容凹部と、
栓体が保持される開口部とを備え、
指掛け収容凹部の底面は指掛け部の指掛け面と反対側の平面に当接し、指掛け収容凹部は、指掛け部の外形と略同一の輪郭を有し、開口部を形成する壁面の一部は栓体の周面に当接し、
指掛け収容凹部内には、指掛け部の平面に当接するシール部が設けられており、
開口部を形成する壁面には、栓体の周面に当接する複数の突出部が設けられ、突出部は周方向で等間隔に配置されていることを特徴とする。 The vacuum plugging jig according to the present invention is brought into contact with a finger hook provided on the syringe outer cylinder in order to depressurize the syringe outer cylinder and load a stopper having a circular section in the syringe outer cylinder. A vacuum punching jig used,
A finger rest accommodating recess for accommodating the flange-shaped finger rest;
An opening for holding the stopper,
The bottom surface of the finger-holding recess is in contact with a plane opposite to the finger-holding surface of the finger-holding portion, the finger-holding recess has an outline substantially the same as the outer shape of the finger-holding portion, and part of the wall surface forming the opening is a plug contact the peripheral surface,
A seal portion that abuts against the plane of the finger hanging portion is provided in the finger hanging accommodating recess,
The wall forming the opening, a plurality of protrusions abutting is provided on the peripheral surface of the plug member, the protruding portion is characterized that you have equally spaced in the circumferential direction.

この真空打栓用治具において、水平に保持された指掛け収容凹部の底面は、指掛け部の指掛け面と反対側の平面に当接するので、シリンジ外筒を鉛直方向にしっかりと位置決めすることができる。さらに、指掛け収容凹部は、指掛け部の外形と略同一の輪郭を有しているので、簡単な構成をもって、治具に対するシリンジ外筒の横ズレの発生をも防止することができる。そして、シリンジ外筒の基端側の開口と治具に保持された栓体との正確な位置合わせが達成されるので、栓体がシリンジ外筒内に無理に押し込まれることなく、栓体をシリンジ外筒内にスムーズに挿入させることができ、気密及び水密性能の低下をもたらす栓体の予期せぬ傾きを発生させることがない。さらに、このような治具を用いることで、シリンジ外筒の基端側の内壁面に通気用の特殊な溝などを形成する必要がない。特に、ガラス製のシリンジ外筒において、通気溝などの特殊な加工は、精密な加工を必要とし、コスト高を招来するので、本発明に係る治具を利用することは特に有効である。   In this vacuum stopper jig, the bottom surface of the finger-holding recess that is held horizontally contacts the plane opposite to the finger-holding surface of the finger-holding portion, so that the syringe outer cylinder can be firmly positioned in the vertical direction. . Furthermore, since the finger-hanging housing recess has substantially the same outline as the outer shape of the finger-hanging portion, it is possible to prevent the lateral displacement of the syringe outer cylinder with respect to the jig with a simple configuration. And since the accurate alignment of the opening on the proximal end side of the syringe outer cylinder and the plug held by the jig is achieved, the plug is not pushed into the syringe outer cylinder and the plug is It can be smoothly inserted into the syringe outer cylinder and does not cause an unexpected inclination of the plug body that causes deterioration in airtightness and watertightness. Furthermore, by using such a jig, it is not necessary to form a special groove for ventilation on the inner wall surface on the proximal end side of the syringe outer cylinder. In particular, in a glass syringe outer cylinder, special processing such as a ventilation groove requires precise processing, resulting in high costs. Therefore, it is particularly effective to use the jig according to the present invention.

さらに、指掛け収容凹部内には、指掛け部の平面に当接するシール部が設けられている。このような構成によって、治具と指掛け部との間の気密性を高めることができる。特に、密着性を高めるためには、弾性及び柔軟性のある材質が好ましく、その一例としてシリコンゴムが有効である。さらに、開口部を形成する壁面には、栓体の周面に当接する複数の突出部が設けられ、突出部は周方向で等間隔に配置されている。周方向で等間隔に設けられた突出部によって、治具内で栓体を確実に保持することができ、しかも、栓体をシリンジ外筒の基端側の開口へ向けて確実に摺動させることができる。さらに、開口部を形成する壁面と栓体との間の隙間も等間隔に設けることができる。 Further, the finger hook accommodating recess, that have seal portion is provided in contact with the plane of the finger grips. With such a configuration, the airtightness between the jig and the finger-hanging portion can be enhanced. In particular, in order to improve the adhesion, a material having elasticity and flexibility is preferable, and silicon rubber is effective as an example. Furthermore, the wall surface forming the opening is provided with a plurality of protrusions that contact the peripheral surface of the plug, and the protrusions are arranged at equal intervals in the circumferential direction. The protrusions provided at equal intervals in the circumferential direction can securely hold the stopper in the jig, and the slider can be reliably slid toward the opening on the proximal end side of the syringe outer cylinder. be able to. Furthermore, the clearance gap between the wall surface and opening which form an opening part can also be provided at equal intervals.

また、開口部は、正多角形であると好適である。このような開口部は成形が容易であり、開口部による栓体の保持と、開口部を形成する壁面と栓体との間の隙間とを等間隔に作り出すことができる。従って、保持部分が等間隔に存在するので、治具内で栓体を安定して保持することができ、しかも、栓体をシリンジ外筒の基端側の開口へ向けて確実に摺動させることができる。さらに、隙間が等間隔に存在するので、シリンジ外筒内の排気を確実に行うことができ、シリンジ外筒内の減圧度を上げることができる。   The opening is preferably a regular polygon. Such an opening is easy to mold, and the holding of the plug by the opening and the gap between the wall surface forming the opening and the plug can be created at equal intervals. Therefore, since the holding portions are present at equal intervals, the stopper can be stably held in the jig, and the stopper is slid reliably toward the opening on the proximal end side of the syringe outer cylinder. be able to. Further, since the gaps exist at equal intervals, the exhaust in the syringe outer cylinder can be reliably performed, and the degree of decompression in the syringe outer cylinder can be increased.

また、突出部には、栓体の挿入側の端部において、テーパ面が形成されていると好適である。このような構成によって、治具の開口部内に栓体を容易に装填することができる。   Further, it is preferable that the protruding portion is formed with a tapered surface at the end portion on the insertion side of the plug body. With such a configuration, the plug can be easily loaded into the opening of the jig.

本発明によれば、簡単な構成をもって、栓体をシリンジ外筒内に確実に挿入させ易い。   According to the present invention, it is easy to reliably insert the stopper into the syringe outer cylinder with a simple configuration.

以下、図面を参照しつつ本発明に係る真空打栓用治具の好適な実施形態について詳細に説明する。   Hereinafter, preferred embodiments of a vacuum stopper jig according to the present invention will be described in detail with reference to the drawings.

図１は、二種類の薬液が予め充填されているプレフィルド型シリンジ１を示し、このシリンジ１は、樹脂又はガラスからなるシリンジ外筒２と、シリンジ外筒２の管軸線に対して直交する方向に延在するフランジ状の指掛け部３と、薬液を注射針から押し出すために先端に摺動弁４ａが固定されたプランジャ４と、シリンジ外筒２内の薬液室Ｐ１，Ｐ２の隔壁をなすゴム製の中間栓５と、シリンジ外筒２の先端に設けられた注射針装着部２ａの注射口を封鎖するゴムキャップ６とから構成されている。   FIG. 1 shows a prefilled syringe 1 pre-filled with two types of chemical solutions. The syringe 1 is a syringe outer cylinder 2 made of resin or glass and a direction perpendicular to the tube axis of the syringe outer cylinder 2. A flange-shaped finger-hanging portion 3 extending to the plunger, a plunger 4 having a sliding valve 4a fixed to the tip for extruding the drug solution from the injection needle, and a rubber forming the partition walls of the drug solution chambers P1 and P2 in the syringe outer cylinder 2 An intermediate stopper 5 made of rubber and a rubber cap 6 that seals the injection port of the injection needle mounting portion 2 a provided at the tip of the syringe outer cylinder 2 are configured.

次に、このような構造のプレフィルド型シリンジ１の製造方法について説明する。なお、キャップ６が取り付けられたシリンジ外筒２は、薬液が注入された状態で搬送コンベア(図示せず)に保持され、所定位置まで搬送されたシリンジ外筒２に向かって真空打栓装置１０は上方から降下する。   Next, a method for manufacturing the prefilled syringe 1 having such a structure will be described. In addition, the syringe outer cylinder 2 to which the cap 6 is attached is held on a conveyor (not shown) in a state where a chemical solution is injected, and the vacuum stopper 10 is directed toward the syringe outer cylinder 2 that has been conveyed to a predetermined position. Descends from above.

図２(ａ)に示すように、真空打栓装置１０の筐体１１の下端には、後述する真空打栓用治具２０がネジ又はチャッキングによって固定されており、この治具２０には、図示しない栓供給装置によって中間栓５が装着される。その後、真空打栓装置１０は、シリンジ外筒２に向かって降下し、このシリンジ外筒２の基端に設けられた楕円状の指掛け部３が治具２０に圧着され、シリンジ外筒２が真空打栓装置１０にセッティングされる。この状態で、筐体１１内の真空チャンバー１２内の空気を真空ポンプにより排気することで、中間栓５の周囲に形成された隙間Ｓ(図４参照)を介してシリンジ外筒２内の空気が真空チャンバー１２内に排出される。その結果、シリンジ外筒２内が減圧される。   As shown in FIG. 2 (a), a vacuum stopper jig 20, which will be described later, is fixed to the lower end of the housing 11 of the vacuum stopper apparatus 10 by screws or chucking. The intermediate plug 5 is mounted by a plug supply device (not shown). Thereafter, the vacuum stopper 10 is lowered toward the syringe outer cylinder 2, and the oval finger hook 3 provided at the proximal end of the syringe outer cylinder 2 is pressure-bonded to the jig 20, so that the syringe outer cylinder 2 is The vacuum stopper device 10 is set. In this state, the air in the vacuum chamber 12 in the housing 11 is exhausted by a vacuum pump, so that the air in the syringe outer cylinder 2 passes through a gap S (see FIG. 4) formed around the intermediate plug 5. Is discharged into the vacuum chamber 12. As a result, the pressure inside the syringe outer cylinder 2 is reduced.

シリンジ外筒２内の減圧完了後、図２(ｂ)に示すように打栓棒１３によって中間栓５を上から押し続け、中間栓５がシリンジ外筒２の基端側の開口２ｂに嵌った状態で、真空チャンバー１２内を外気と連通させて、真空チャンバー１２内に空気を導入させる。これによって、真空チャンバー１２内が大気圧まで上昇し、図２(ｃ)に示すように、打栓棒１３により中間栓５を押し続けることで、中間栓５を、シリンジ外筒２内の薬液面に達するまで容易に降下させることができる。その後、別の薬液がシリンジ外筒２内に充填され、別の真空打栓装置によって、シリンジ外筒２内の空気を真空ポンプによって排気した後、プランジャ４をシリンジ外筒２に装填する。   After the pressure reduction in the syringe outer cylinder 2 is completed, as shown in FIG. 2 (b), the intermediate stopper 5 is continuously pushed from above by the stopper rod 13, and the intermediate stopper 5 fits into the opening 2 b on the proximal end side of the syringe outer cylinder 2. In this state, the inside of the vacuum chamber 12 is communicated with the outside air, and air is introduced into the vacuum chamber 12. As a result, the inside of the vacuum chamber 12 rises to atmospheric pressure, and as shown in FIG. 2 (c), the intermediate plug 5 is kept pressed by the stopper rod 13, so that the intermediate plug 5 is moved to the chemical solution in the syringe outer cylinder 2. It can be easily lowered until it reaches the surface. Thereafter, another chemical solution is filled in the syringe outer cylinder 2, and after the air in the syringe outer cylinder 2 is exhausted by a vacuum pump by another vacuum stopper device, the plunger 4 is loaded into the syringe outer cylinder 2.

次に、このようなプレフィルド型シリンジ１の製造方法に適用する前述の真空打栓用治具２０について詳細に説明する。   Next, the above-described vacuum stopper jig 20 applied to the method for manufacturing such a prefilled syringe 1 will be described in detail.

図３〜図５に示すように、プレフィルド型シリンジ１の製造時において、断面円形のゴム製の中間栓５を保持させておくための真空打栓用治具２０は、樹脂又は金属によって成形された治具本体Ａを備え、真空打栓用治具２０は、治具本体Ａと後述のシール部２５とで構成され、真空打栓装置１０の筐体１１の下端に対してネジやクランプなどの着脱自在な締結手段又は溶接によって固定されている。この治具２０は、プレート状に成形され、治具２０における治具本体Ａの平坦面２０ａには、楕円のフランジ状をなす指掛け部３を収容するための指掛け収容凹部２１が設けられている。 As shown in FIGS. 3 to 5, when manufacturing the prefilled syringe 1, the vacuum stopper jig 20 for holding the rubber intermediate stopper 5 having a circular cross section is formed of resin or metal. The vacuum punching jig 20 includes a jig main body A and a seal portion 25 described later. A screw, a clamp, or the like is attached to the lower end of the housing 11 of the vacuum stopper 10. These are fixed by detachable fastening means or welding. The jig 20 is formed in a plate shape, and a finger hook receiving recess 21 for receiving the finger hook 3 having an elliptical flange shape is provided on the flat surface 20a of the jig main body A of the jig 20. .

水平に保持された指掛け収容凹部２１の底面２１ａは、指掛け部３の指掛け面３ａと反対側の平面３ｂに密着するので、シリンジ外筒２を鉛直方向にしっかりと位置決めさせることができる。また、指掛け収容凹部２１の輪郭は、指掛け部３の外形と略同一に形成され、治具２０に対するシリンジ外筒２の横ズレの発生を防止することができる。すなわち、指掛け部３が楕円形状であれば、指掛け収容凹部２１の輪郭も楕円に成形することで、指掛け部３は、ほとんどガタの無い状態で指掛け収容凹部２１内にピッタリと嵌り込む。   Since the bottom surface 21a of the finger-holding recess 21 held horizontally is in close contact with the flat surface 3b opposite to the finger-holding surface 3a of the finger-holding portion 3, the syringe outer cylinder 2 can be firmly positioned in the vertical direction. In addition, the outline of the finger-holding recess 21 is formed to be substantially the same as the outer shape of the finger-holding part 3, and the lateral displacement of the syringe outer cylinder 2 with respect to the jig 20 can be prevented. That is, if the finger-hanging portion 3 is oval, the finger-holding recess 21 is also shaped into an ellipse, so that the finger-holding portion 3 fits in the finger-holding recess 21 with almost no play.

指掛け収容凹部２１内には、指掛け部３の平面３ｂに当接する平板状のシール部２５が設けられ、中央に開口部２５ａを有するシール部２５の輪郭は、指掛け収容凹部２１の外形と略同一に形成され、シール部２５は、指掛け収容凹部２１内にしっかりと嵌り込んでいる。シール部２５の採用により、治具２０と指掛け部３との間の気密性を高めることができる。特に、シール部２５は、弾性及び柔軟性のある材質が好ましく、その一例としてシリコンゴムが有効である。   A flat seal portion 25 that abuts on the flat surface 3 b of the finger hook portion 3 is provided in the finger hook receiving recess 21, and the outline of the seal portion 25 having an opening 25 a in the center is substantially the same as the outer shape of the finger hook receiving recess 21. The seal portion 25 is firmly fitted in the finger hook receiving recess 21. By adopting the seal portion 25, the airtightness between the jig 20 and the finger hook portion 3 can be enhanced. In particular, the seal portion 25 is preferably made of an elastic and flexible material, and silicon rubber is effective as an example.

この治具２０の中央には、指掛け収容凹部２１及び筐体１１の下端の打栓棒挿通口１１ａ(図２参照)と連通する開口部２２が形成されている。この開口部２２内で中間栓５を保持するために、開口部２２を形成する壁面には、中間栓５の周面に当接させるための３個の突起部２３が設けられている。これら突起部２３は、同一形状であると共に、周方向で等間隔に配置されている。従って、打栓棒１３によって押圧され続ける中間栓５は、傾くことなく、シリンジ外筒２の基端側の開口２ｂへ向けて確実に摺動させることができる。   In the center of the jig 20, an opening 22 is formed that communicates with the finger-holding recess 21 and the stopper rod insertion opening 11 a (see FIG. 2) at the lower end of the housing 11. In order to hold the intermediate plug 5 in the opening 22, three protrusions 23 for contacting the peripheral surface of the intermediate plug 5 are provided on the wall surface forming the opening 22. These protrusions 23 have the same shape and are arranged at equal intervals in the circumferential direction. Therefore, the intermediate stopper 5 that is continuously pressed by the stopper rod 13 can be reliably slid toward the opening 2b on the proximal end side of the syringe outer cylinder 2 without being inclined.

さらに、開口部２２を形成する壁面と中間栓５との間の隙間Ｓも等間隔に設けられることになる。各隙間Ｓは、シリンジ外筒２内の減圧の時に利用され、隙間Ｓを均等に配置させることで、均一な排気が可能になり、シリンジ外筒２内の減圧度を上げることができる。また、突出部２３には、中間栓５の挿入側の端部において、テーパ面２３ａが形成されている。これによって、治具２０の開口部２２内に中間栓５を上方から容易に装填することができる。   Further, the gaps S between the wall surface forming the opening 22 and the intermediate plug 5 are also provided at equal intervals. Each gap S is used when the pressure in the syringe outer cylinder 2 is reduced. By arranging the gaps S evenly, uniform exhaust is possible and the degree of pressure reduction in the syringe outer cylinder 2 can be increased. Further, the protruding portion 23 is formed with a tapered surface 23 a at the end portion on the insertion side of the intermediate plug 5. Thereby, the intermediate plug 5 can be easily loaded into the opening 22 of the jig 20 from above.

この真空打栓用治具２０においては、水平方向に延在する指掛け収容凹部２１の底面２１ａは指掛け部３の指掛け面３ａと反対側の平面３ｂに密着するので、シリンジ外筒２を鉛直方向にしっかりと位置決めすることができる。指掛け収容凹部２１は、指掛け部３の外形と略同一の輪郭を有しているので、簡単な構成をもって、治具２０に対するシリンジ外筒２の横ズレの発生を防止することができる。そして、シリンジ外筒２の基端側の開口２ｂと治具２０に保持された中間栓５との正確な位置合わせが達成されるので、中間栓５は、シリンジ外筒２内に無理に押し込まれることなく、スムーズに挿入され、気密及び水密性能の低下をもたらす中間栓５の予期せぬ傾きを発生させることがない。   In this vacuum stopper jig 20, the bottom surface 21 a of the finger hook receiving recess 21 extending in the horizontal direction is in close contact with the flat surface 3 b opposite to the finger hook surface 3 a of the finger hook 3, so that the syringe outer cylinder 2 is placed in the vertical direction. Can be firmly positioned. Since the finger-holding recess 21 has substantially the same outline as the outer shape of the finger-holding portion 3, it is possible to prevent the lateral displacement of the syringe outer cylinder 2 with respect to the jig 20 with a simple configuration. And since the exact position alignment with the opening 2b of the base end side of the syringe outer cylinder 2 and the intermediate stopper 5 hold | maintained at the jig | tool 20 is achieved, the intermediate stopper 5 is pushed into the syringe outer cylinder 2 forcibly. Therefore, the intermediate plug 5 is inserted smoothly and does not cause an unexpected inclination of the intermediate plug 5 that causes deterioration in airtightness and watertightness.

さらに、このような治具２０を用いることで、シリンジ外筒２の基端側の内壁面に通気用の特殊な溝などを形成する必要がない。特に、ガラス製のシリンジ外筒２において、通気溝などの特殊な加工は、精密な加工を必要とし、コスト高を招来するので、本発明に係る治具を利用することは特に有効である。   Furthermore, by using such a jig 20, it is not necessary to form a special groove or the like for ventilation on the inner wall surface on the proximal end side of the syringe outer cylinder 2. In particular, in the glass syringe outer cylinder 2, special processing such as a ventilation groove requires precise processing, resulting in high costs. Therefore, it is particularly effective to use the jig according to the present invention.

本発明は、前述した実施形態に限定されないことは言うまでもない。   It goes without saying that the present invention is not limited to the embodiment described above.

例えば、図６は他の治具３０を示し、この治具３０の指掛け収容凹部２１は楕円形の起立片２７によって形成されている。   For example, FIG. 6 shows another jig 30, and the finger-holding recess 21 of the jig 30 is formed by an elliptic standing piece 27.

また、図７に示すように、さらに他の治具４０では、開口部４１が正方形に形成されている。このような開口部４１は成形が容易であり、開口部４１による中間栓５の保持と、開口部４１を形成する壁面と中間栓５との間の隙間Ｓとを等間隔に作り出すことができる。従って、保持部分Ｈが等間隔に存在するので、治具４０内で中間栓５を安定して保持することができ、しかも、中間栓５をシリンジ外筒２の基端側の開口２ｂへ向けて確実に摺動させることができる。さらに、隙間Ｓが等間隔に存在するので、シリンジ外筒２内の排気を確実に行うことができ、シリンジ外筒２内の減圧度を上げることができる。なお、開口部４１は、多角形であればよく、例えば、正三角形、正五角形、正六角形、正八角形であってもよい。   Moreover, as shown in FIG. 7, in still another jig 40, the opening 41 is formed in a square shape. Such an opening 41 can be easily formed, and can hold the intermediate plug 5 by the opening 41 and the gap S between the wall surface forming the opening 41 and the intermediate plug 5 at equal intervals. . Accordingly, since the holding portions H exist at equal intervals, the intermediate stopper 5 can be stably held in the jig 40, and the intermediate stopper 5 is directed toward the opening 2b on the proximal end side of the syringe outer cylinder 2. And can be slid reliably. Further, since the gaps S are present at equal intervals, the exhaust in the syringe outer cylinder 2 can be reliably performed, and the degree of decompression in the syringe outer cylinder 2 can be increased. In addition, the opening part 41 should just be a polygon, for example, a regular triangle, a regular pentagon, a regular hexagon, and a regular octagon may be sufficient as it.

栓体としては、中間栓５に限らず、プランジャ４の摺動弁４ａであってもよく、シリンジ外筒２の基端側の開口２ｂに装填される外栓であってもよい。中間栓５の外周面にはリップ部が設けられてもよい。指掛け部３の形状は、楕円に限らず、円形であってもＩ形であってもよい。   The plug body is not limited to the intermediate plug 5, but may be a sliding valve 4 a of the plunger 4, or an external plug loaded in the opening 2 b on the proximal end side of the syringe outer cylinder 2. A lip portion may be provided on the outer peripheral surface of the intermediate plug 5. The shape of the finger hook portion 3 is not limited to an ellipse, and may be circular or I-shaped.

突起部２３の形状は、円弧状、三角状であってもよく、突起部２３の個数は、複数であれば良い。   The shape of the protrusion 23 may be an arc shape or a triangle, and the number of the protrusions 23 may be plural.

治具２０，３０，４０は、真空打栓装置１０の筐体１１の下端に一体成形されていてもよい。   The jigs 20, 30, and 40 may be integrally formed at the lower end of the housing 11 of the vacuum stopper device 10.

プレフィルド型シリンジを示す断面図である。It is sectional drawing which shows a prefilled type syringe. プレフィルド型シリンジの製造方法を示す断面図である。It is sectional drawing which shows the manufacturing method of a prefilled type syringe. 本発明に係る真空打栓用治具を示す斜視図である。It is a perspective view which shows the jig | tool for vacuum stoppers which concerns on this invention. 真空打栓用治具の平面図である。It is a top view of the jig for vacuum stoppers. 図４のＩＶ−ＩＶ線に沿う断面図である。It is sectional drawing which follows the IV-IV line of FIG. 他の真空打栓用治具を示す斜視図である。It is a perspective view which shows the jig for other vacuum stoppers. さらに他の真空打栓用治具を示す斜視図である。It is a perspective view which shows the other jig | tool for vacuum stoppers.

符号の説明Explanation of symbols

２０，３０，４０…真空打栓用治具、２…シリンジ外筒、３…指掛け部、３ａ…指掛け面、５…中間栓(栓体)、２１…指掛け収容凹部、２１ａ…指掛け収容凹部の底面、２２，４１…開口部、２３…突出部、２３ａ…テーパ面、２５…シール部。   20, 30, 40 ... Vacuum stopper jig, 2 ... Syringe cylinder, 3 ... Finger hook, 3a ... Finger hook, 5 ... Intermediate plug (plug), 21 ... Finger hook receiving recess, 21a ... Finger hook receiving recess Bottom surface, 22, 41 ... opening, 23 ... protrusion, 23a ... taper surface, 25 ... seal part.

Claims (3)

シリンジ外筒内を減圧させて前記シリンジ外筒内に断面円形の栓体を装填させるために、前記シリンジ外筒に設けられた指掛け部に当接させて利用される真空打栓用治具であって、
フランジ状の前記指掛け部を収容する指掛け収容凹部と、
前記栓体が保持される開口部とを備え、
前記指掛け収容凹部の底面は前記指掛け部の指掛け面と反対側の平面に当接し、前記指掛け収容凹部は、前記指掛け部の外形と略同一の輪郭を有し、前記開口部を形成する壁面の一部は前記栓体の周面に当接し、
前記指掛け収容凹部内には、前記指掛け部の前記平面に当接するシール部が設けられており、
前記開口部を形成する前記壁面には、前記栓体の前記周面に当接する複数の突出部が設けられ、前記突出部は周方向で等間隔に配置されていることを特徴とする真空打栓用治具。 In order to depressurize the inside of the syringe outer cylinder and load a stopper having a circular cross section into the syringe outer cylinder, a vacuum plugging jig used in contact with a finger hook provided on the syringe outer cylinder There,
A finger hook receiving recess for receiving the flange-shaped finger hook;
An opening for holding the stopper,
The bottom surface of the finger-hanging recess is in contact with a plane opposite to the finger-holding surface of the finger-holding portion, and the finger-holding recess has an outline substantially the same as the outer shape of the finger-holding portion and is a wall surface that forms the opening. some come in contact with the peripheral surface of the plug body,
A seal portion that contacts the flat surface of the finger-hanging portion is provided in the finger-holding recess,
Vacuum hitting the said wall surface forming the opening, a plurality of protrusions abutting is provided on the peripheral surface of the plug member, the protrusion is characterized that you have equally spaced in the circumferential direction Jig for stopper. 前記開口部は、正多角形であることを特徴とする請求項１記載の真空打栓用治具。 The opening jig vacuum capping of claim 1 Symbol mounting characterized in that it is a regular polygon. 前記突出部には、前記栓体の挿入側の端部において、テーパ面が形成されていることを特徴とする請求項１又は２記載の真空打栓用治具。 The vacuum plugging jig according to claim 1 or 2 , wherein a taper surface is formed on the protruding portion at an end of the plug on the insertion side.
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JP2020531057A (en) 2017-06-29 2020-11-05 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Devices and methods for filling chemical containers
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