JP5014803B2 - 押し込み変位洗浄注射器 - Google Patents
押し込み変位洗浄注射器 Download PDFInfo
- Publication number
- JP5014803B2 JP5014803B2 JP2006549461A JP2006549461A JP5014803B2 JP 5014803 B2 JP5014803 B2 JP 5014803B2 JP 2006549461 A JP2006549461 A JP 2006549461A JP 2006549461 A JP2006549461 A JP 2006549461A JP 5014803 B2 JP5014803 B2 JP 5014803B2
- Authority
- JP
- Japan
- Prior art keywords
- stopper
- syringe assembly
- syringe
- fluid
- barrel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000004140 cleaning Methods 0.000 title claims description 57
- 238000006073 displacement reaction Methods 0.000 title description 5
- 239000012530 fluid Substances 0.000 claims description 64
- 239000007788 liquid Substances 0.000 claims description 22
- 230000002093 peripheral effect Effects 0.000 claims description 15
- 238000004891 communication Methods 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- 229920000669 heparin Polymers 0.000 claims description 7
- 239000011780 sodium chloride Substances 0.000 claims description 6
- 238000005406 washing Methods 0.000 claims description 6
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 5
- 229960002897 heparin Drugs 0.000 claims description 5
- 229920003052 natural elastomer Polymers 0.000 claims description 4
- 229920001194 natural rubber Polymers 0.000 claims description 4
- 229920003051 synthetic elastomer Polymers 0.000 claims description 4
- 239000005061 synthetic rubber Substances 0.000 claims description 4
- 229920002725 thermoplastic elastomer Polymers 0.000 claims description 4
- 239000012815 thermoplastic material Substances 0.000 claims description 4
- 244000043261 Hevea brasiliensis Species 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 230000002262 irrigation Effects 0.000 description 30
- 238000003973 irrigation Methods 0.000 description 30
- 238000000034 method Methods 0.000 description 22
- 210000003462 vein Anatomy 0.000 description 13
- 230000007246 mechanism Effects 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 230000009467 reduction Effects 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 230000000712 assembly Effects 0.000 description 2
- 238000000429 assembly Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 210000004247 hand Anatomy 0.000 description 2
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical group CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 2
- 229960001008 heparin sodium Drugs 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- 238000012371 Aseptic Filling Methods 0.000 description 1
- 241001602876 Nata Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 208000037815 bloodstream infection Diseases 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000013536 elastomeric material Substances 0.000 description 1
- 230000005281 excited state Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229940113601 irrigation solution Drugs 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 235000016236 parenteral nutrition Nutrition 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000012414 sterilization procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 210000002073 venous valve Anatomy 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M2005/31516—Piston or piston-rod constructions, e.g. connection of piston with piston-rod reducing dead-space in the syringe barrel after delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31515—Connection of piston with piston rod
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
Claims (16)
- 流体を保持するためのチャンバを画成する内面を持った円筒状の側壁と、開口基端部と、末端側に延在して前記チャンバとの間で流体が連通する通路を有するチップを持った末端壁を含む末端部とを含むバレルと、
基端部および末端部を有すると共に前記バレルの開口基端部から外側に延在する細長い本体部と、前記バレルの内面に対し流体密封状態で摺動可能に配され、かつ前記バレルに対して移動して流体を前記チャンバから送出するためのストッパとを含むプランジャと
を具え、前記ストッパは、末端壁および内面を画成するキャビティを有する末端部と、基端部とを含み、前記末端壁は、少なくとも一部が洗浄処置における液圧により前記キャビティへとつぶれ、洗浄処置の完了時にその元の形状に向けて復元し、追加の流体を前記通路へと押し込むように、充分な可撓性を有し、
前記キャビティの内面にばねを含み、このばねは、前記ストッパがつぶれた位置にある場合に圧縮され、このつぶれた位置から前記末端壁をその元の形状に向けて付勢するように形成されていることを特徴とする洗浄注射器アセンブリ。 - 前記プランジャの前記末端部の末端チップが前記ストッパに連結されていることを特徴とする請求項1に記載の注射器アセンブリ。
- 前記プランジャの末端部の末端チップは、前記バレルの内面に対して流体密封状態でその外周を取り囲むシール面を含むことを特徴とする請求項1に記載の注射器アセンブリ。
- 前記末端壁のつぶれは、前記チャンバ内の液圧が約5mmHg(0.1psi)以上の場合に発生することを特徴とする請求項1に記載の注射器アセンブリ。
- 前記注射器を末梢カテーテルに連結した場合、前記追加の流体の体積が約0.001ml以上であることを特徴とする請求項1に記載の注射器アセンブリ。
- 前記注射器を末梢カテーテルに連結した場合、前記追加の流体が0.5秒以上の時間で送出されることを特徴とする請求項1に記載の注射器アセンブリ。
- 前記注射器を末梢カテーテルに連結した場合、前記追加の流体が2.5秒以上の時間で送出されることを特徴とする請求項1に記載の注射器アセンブリ。
- 前記ストッパが円錐状に形成された末端面を含み、前記バレルの内面の前記末端壁が円錐状に形成されていることを特徴とする請求項1に記載の注射器アセンブリ。
- 前記末端壁がつぶれるように、前記ストッパのキャビティに閉じ込められた空気の漏出を可能にする手段をさらに含むことを特徴とする請求項1に記載の注射器アセンブリ。
- 空気の漏出を可能にする前記手段は、前記ストッパのキャビティと連通する前記プランジャの穴を含むことを特徴とする請求項9に記載の注射器アセンブリ。
- 前記チャンバ内に洗浄液を含むことを特徴とする請求項1に記載の注射器アセンブリ。
- 前記洗浄液が食塩洗浄液およびヘパリンロック洗浄液からなるグループから選択されることを特徴とする請求項11に記載の注射器アセンブリ。
- 前記注射器バレルの前記チップに取り外し可能に連結されて前記通路を塞ぐチップキャップをさらに含むことを特徴とする請求項12に記載の注射器アセンブリ。
- 前記ストッパは、熱可塑性エラストマー,天然ゴム,合成ゴム,熱可塑性材料およびこれらの組み合わせからなる一覧から選択される材料から作られていることを特徴とする請求項1に記載の注射器アセンブリ。
- 基端部,末端部および管腔を有するカニューレと、キャビティを包含する開口基端部および前記管腔と前記キャビティとの間を流体が連通するように前記カニューレの基端部に装着される末端部を有するハブとを含む注射針アセンブリをさらに具え、この注射針アセンブリは、前記管腔と前記チャンバとの間を流体が連通するように、前記キャビティに対する前記チップの係合により前記バレルのチップに取り外し可能に装着されていることを特徴とする請求項1に記載の注射器アセンブリ。
- 前記ばねが前記内面の凹部に配されていることを特徴とする請求項1に記載の注射器アセンブリ。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53555704P | 2004-01-09 | 2004-01-09 | |
US60/535,557 | 2004-01-09 | ||
PCT/US2005/000624 WO2005070485A1 (en) | 2004-01-09 | 2005-01-07 | Positive displacement flush syringe |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010258125A Division JP5160623B2 (ja) | 2004-01-09 | 2010-11-18 | 押し込み変位洗浄注射器 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2007517613A JP2007517613A (ja) | 2007-07-05 |
JP2007517613A5 JP2007517613A5 (ja) | 2008-02-28 |
JP5014803B2 true JP5014803B2 (ja) | 2012-08-29 |
Family
ID=34806945
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006549461A Active JP5014803B2 (ja) | 2004-01-09 | 2005-01-07 | 押し込み変位洗浄注射器 |
JP2010258125A Active JP5160623B2 (ja) | 2004-01-09 | 2010-11-18 | 押し込み変位洗浄注射器 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010258125A Active JP5160623B2 (ja) | 2004-01-09 | 2010-11-18 | 押し込み変位洗浄注射器 |
Country Status (6)
Country | Link |
---|---|
US (1) | US8007475B2 (ja) |
EP (2) | EP3323450B1 (ja) |
JP (2) | JP5014803B2 (ja) |
BR (1) | BRPI0506716B8 (ja) |
ES (2) | ES2764664T3 (ja) |
WO (1) | WO2005070485A1 (ja) |
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JP4602579B2 (ja) * | 2001-03-15 | 2010-12-22 | テルモ株式会社 | シリンジ |
JP4133071B2 (ja) * | 2001-08-20 | 2008-08-13 | 大成化工株式会社 | 後垂れ防止注入器、並びに、該注入器用プランジャ及びシール体 |
US7070581B2 (en) * | 2002-04-05 | 2006-07-04 | Comar, Inc. | Dispenser for medicaments and method and apparatus for making same |
US20050063857A1 (en) * | 2003-09-23 | 2005-03-24 | Alheidt Thomas A. | Flush syringe having anti-reflux stopper |
ES2764664T3 (es) * | 2004-01-09 | 2020-06-04 | Becton Dickinson Co | Jeringuilla de enjuague con desplazamiento positivo |
US20050154353A1 (en) * | 2004-01-09 | 2005-07-14 | Alheidt Thomas A. | Positive displacement flush syringe |
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2005
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- 2005-01-07 BR BRPI0506716A patent/BRPI0506716B8/pt active IP Right Grant
- 2005-01-07 WO PCT/US2005/000624 patent/WO2005070485A1/en active Application Filing
- 2005-01-07 EP EP17208436.0A patent/EP3323450B1/en active Active
- 2005-01-07 US US10/594,335 patent/US8007475B2/en active Active
- 2005-01-07 ES ES05705335.7T patent/ES2672623T3/es active Active
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Publication number | Publication date |
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BRPI0506716A (pt) | 2007-05-02 |
BRPI0506716B1 (pt) | 2016-02-10 |
EP3323450A1 (en) | 2018-05-23 |
JP2007517613A (ja) | 2007-07-05 |
ES2672623T3 (es) | 2018-06-15 |
EP1703931A1 (en) | 2006-09-27 |
JP5160623B2 (ja) | 2013-03-13 |
WO2005070485A1 (en) | 2005-08-04 |
BRPI0506716B8 (pt) | 2021-06-22 |
US8007475B2 (en) | 2011-08-30 |
ES2764664T3 (es) | 2020-06-04 |
US20070179452A1 (en) | 2007-08-02 |
JP2011031087A (ja) | 2011-02-17 |
EP3323450B1 (en) | 2019-10-09 |
EP1703931B1 (en) | 2018-03-07 |
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