JP4964272B2 - 関節軟骨の欠陥を修復するための装置及び方法 - Google Patents
関節軟骨の欠陥を修復するための装置及び方法 Download PDFInfo
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- JP4964272B2 JP4964272B2 JP2009112669A JP2009112669A JP4964272B2 JP 4964272 B2 JP4964272 B2 JP 4964272B2 JP 2009112669 A JP2009112669 A JP 2009112669A JP 2009112669 A JP2009112669 A JP 2009112669A JP 4964272 B2 JP4964272 B2 JP 4964272B2
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- capsule forming
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Description
(微小骨折術及び研磨関節形成術)
図5を参照すると、関節軟骨の欠陥55が最初に微小骨折術及び研磨関節形成術により処置されることが示されている。
(万能幹細胞を用いた微小骨折術及び研磨関節形成術)
傷部内にカプセル形成装置5を配置する前に、万能幹細胞を用いて、傷部箇所に種蒔き状態を作り出すことも可能である。カプセル形成装置は、該カプセル形成装置が吸収され、再形成されるまで、傷部箇所で万能幹細胞を覆うことになる。本発明の一つの好ましい形態では、万能幹細胞は、身体の様々な領域(例えば、大腿切痕、腸骨稜、脊椎骨)から骨髄を吸い上げることにより採取され、次に、カプセル形成装置5の配置前又はこれと同時に、骨髄を傷部箇所に配置する。代替として、採取された骨髄は、万能幹細胞のより効能のあるスラリーを生成するように、種蒔き前に、フィルター処理されてもよい。
(自家細胞移植)
欠陥箇所でカプセル形成装置5を配置する前に、自家関節軟骨細胞を用いて、関節軟骨の欠陥55に種蒔きすることも可能である。カプセル形成装置は、該カプセル形成装置が吸収され、再構成されるまで、傷部箇所で自家関節軟骨細胞を覆うことになる。本発明の一つの好ましい形態では、自家関節軟骨細胞は、身体外部で採取、準備され(例えば、分離され、及び/又は、成長因子で強化され、及び/又は、増殖される)、次に、カプセル形成装置5の配置前又はこれと同時に、欠陥箇所に配置される。
(他の代替実施例)
次に図13を参照すると、本発明の代替形態を備えるカプセル形成装置5Aが示されている。カプセル形成装置5Aは、前述したカバー14というよりも、ボディ10Aがボディ10A内部の1つ以上の位置でマトリックス又はメッシュ85Aを備えている点を除いて、上述したカプセル形成装置5に類似している。1つ以上の脚部25Aがボディ10Aから延在している。マトリックス又はメッシュ85Aでボディ10Aを形成することは、例えば、微小骨折術及び研磨関節形成術の場合に、中実ボディ10を超える効果を奏することができる。それは、当該箇所に栄養物の優れた流れを提供し、当該箇所から浪費物の優れた流れを提供するか、又は、万能幹細胞を用いた微小骨折術及び研磨関節形成術の場合には、それは、欠陥箇所でカプセル形成装置を展開する前にカプセル形成装置上にそのような細胞のスラリーを配置することを可能にする。自家細胞移植の場合には、それは、移植関節軟骨細胞のスラリーを、欠陥箇所にカプセル形成装置を配置する前にカプセル形成装置上に配置することを可能にする。
Claims (8)
- 関節軟骨の欠陥の修復のためのカプセル形成装置であって、
前記軟骨欠陥の領域で骨に隣接して配置するためのボディと、
前記軟骨欠陥の領域で前記骨に配置するため前記ボディから延在する、細長い脚構成部であって、前記ボディの厚さよりも大きい複数段階の長さを有し、略錐体の形状を有する、前記脚構成部と、
を備え、
前記ボディは、周辺フレームと該周辺フレーム内に配置されたメッシュ部を備える、カプセル形成装置。 - 関節軟骨の欠陥の修復のためのカプセル形成装置であって、
前記軟骨欠陥の領域で骨に隣接して配置するためのボディと、
前記軟骨欠陥の領域で前記骨に配置するため前記ボディから延在する、細長い脚構成部であって、前記ボディの厚さよりも大きい複数段階の長さを有し、略錐体の形状を有する、前記脚構成部と、
を備え、
前記ボディは、周辺フレームと該周辺フレーム内に配置されたコラーゲンの足場を備える、カプセル形成装置。 - 関節軟骨の欠陥の修復のためのカプセル形成装置であって、
前記軟骨欠陥の領域で骨に隣接して配置するためのボディと、
前記軟骨欠陥の領域で前記骨に配置するため前記ボディから延在する、細長い脚構成部であって、前記ボディの厚さよりも大きい複数段階の長さを有し、略錐体の形状を有する、前記脚構成部と、
を備え、
前記ボディは、周辺フレームと、該周辺フレーム内に配置されて該周辺フレームに固定された骨膜のシートと、を備える、
カプセル形成装置。 - 前記シートを前記周辺フレームに付着させる縫合糸を更に備える、請求項3に記載のカプセル形成装置。
- 関節軟骨の欠陥の修復のためのカプセル形成装置であって、
前記軟骨欠陥の領域で骨に隣接して配置するためのボディと、
前記軟骨欠陥の領域で前記骨に配置するため前記ボディから延在する、細長い脚構成部であって、前記ボディの厚さよりも大きい複数段階の長さを有し、略錐体の形状を有する、前記脚構成部と、
を備え、
前記ボディは、カバー部の境界を形成する周辺フレームを備える、記載のカプセル形成装
置。 - 前記脚構成部は、挿管されている、請求項1,2,3又は5に記載のカプセル形成装置。
- 前記装置は、(i)生体吸収可能材料、及び、(ii)生体再形成可能な材料のうち選択された一つから形成される、請求項1,2,3又は5に記載のカプセル形成装置。
- 前記装置は、細胞成長材料で含浸されている、請求項1,2,3又は5に記載のカプセル形成装置。
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EP1437960B1 (en) | 2008-12-10 |
US20030083665A1 (en) | 2003-05-01 |
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ES2318040T3 (es) | 2009-05-01 |
JP2009195732A (ja) | 2009-09-03 |
WO2003028535A3 (en) | 2003-11-20 |
US20040181232A1 (en) | 2004-09-16 |
CA2462256A1 (en) | 2003-04-10 |
CA2462256C (en) | 2010-06-01 |
ATE416682T1 (de) | 2008-12-15 |
EP1437960A2 (en) | 2004-07-21 |
WO2003028535A2 (en) | 2003-04-10 |
JP4330991B2 (ja) | 2009-09-16 |
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