JP4963670B2 - 栄養補助サプリメントおよびそれを処理する方法 - Google Patents
栄養補助サプリメントおよびそれを処理する方法 Download PDFInfo
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- JP4963670B2 JP4963670B2 JP2007507358A JP2007507358A JP4963670B2 JP 4963670 B2 JP4963670 B2 JP 4963670B2 JP 2007507358 A JP2007507358 A JP 2007507358A JP 2007507358 A JP2007507358 A JP 2007507358A JP 4963670 B2 JP4963670 B2 JP 4963670B2
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- resveratrol
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- Expired - Fee Related
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- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1 Chemical compound Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Botany (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Description
本出願は、発明の名称「Dietary Supplement and Method of Processing Same」であり、2003年10月23日に出願された米国仮特許出願番号60/59,955に基づく優先権を主張する。上記の仮特許出願の開示は、その全体が本明細書中に参考として援用される。
本発明は、生物学的に活性な低分子を含有するカプセル化された組成物および、生物活性を維持(特に、サーチュイン(Sirtuin)1遺伝子を活性化(発現)または非活性化(サイレント)する能力を維持)するように組成物を処理する方法に関する。
したがって、上記に照らし、そして本発明が記載される場合に明らかとなる他の理由に関して、本発明の目的は、生物学的に活性なレスベラトロルを含有するカプセル化された組成物を提供し、そしてレスベラトロルが、消費者に摂取される場合に生物学的に活性なままであるように、この組成物をカプセル化する方法を提供することである。
本発明の1つの実施形態は、植物に由来するか、または合成的に生成される低分子を含有する組成物、および延長された期間、その生物活性を維持するようにこの組成物をカプセル化する方法に関する。植物の供給源または合成の供給源による生物学的に活性な低分子は、植物性低分子ポリフェノール(例えば、レスベラトロル、ケルセチン、フィセチン、ブテイン(butein)、ピセアトノール(piceatonol)、イソリキリチゲニン(isoliquiritigenin))を含み得、これらは、その小さいサイズおよび低分子量によって、細胞壁を通過し、細胞核に進入し、そして特定の遺伝子制御された機構を変化させ得る。好ましい植物性低分子ポリフェノールは、レスベラトロル(分子量228.25)であり、これは、他のポリフェノールより良好にサーチュイン−1制御性の酵素活性を活性化することが示された。しかし、他の低分子は、利用され得る。レスベラトロルは、合成的に生成されても、植物材料(ブドウおよびタデが挙げられる)のような供給源から天然に得られてもよい。好ましくは、レスベラトロルとしては、トランス立体異性体の分子(すなわち、トランス−3,4’,5トリヒドロキシスチルベン)が挙げられ、これは、以下:
Claims (12)
- レシピエント動物に投与するための組成物であって、該組成物は、以下:
ブドウ抽出物とPolygonum抽出物の混合物であって、該混合物は、トランス−レスベラトロルを含み、該トランス−レスベラトロルは、5重量%〜30重量%の量で該組成物中に存在する、混合物と;
25重量%以下の量の米ぬか抽出物であって、該米ぬか抽出物は、金属キレート剤を含む、米ぬか抽出物と;
50重量%以下の総量の1種以上のさらなるフェノール性抗酸化剤と
を含み、該組成物が、不透明な空気を通さないカプセル内にカプセル化される、組成物。 - 前記トランス−レスベラトロルが、10重量%〜20重量%の量で存在する、請求項1に記載の組成物。
- 前記金属キレート剤がフィチン酸である、請求項1に記載の組成物。
- 前記金属キレート剤が7重量%〜10重量%の量で存在する、請求項1に記載の組成物。
- 前記1種以上のさらなるフェノール性抗酸化剤がフラボノイド抗酸化剤を含む、請求項1に記載の組成物。
- 前記フラボノイド抗酸化剤がケルセチンを含む、請求項5に記載の組成物。
- 前記1種以上のさらなるフェノール性抗酸化剤が15重量%〜35重量%の総量で存在する、請求項1に記載の組成物。
- 前記1種以上のさらなるフェノール性抗酸化剤が20重量%〜30重量%の総量で存在する、請求項1に記載の組成物。
- 前記組成物が、実質的に光および酸素が存在しない環境下でカプセル化される、請求項1に記載の組成物。
- 請求項1に記載の組成物であって、ここで:
前記トランス−レスベラトロルが10重量%〜20重量%の量で存在し、
前記米ぬか抽出物が、7重量%〜10重量%の量のフィチン酸を含み、そして
前記1種以上のさらなるフェノール性抗酸化剤が、20重量%〜30重量%の総量で存在する、
組成物。 - 前記ブドウ抽出物が、Vitis viniferaまたはVitis labruscaの抽出物である、請求項1に記載の組成物。
- 前記Polygonum抽出物が、Polygonum cuspidatumの抽出物である、請求項1に記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55995504P | 2004-04-07 | 2004-04-07 | |
US60/559,955 | 2004-04-07 | ||
PCT/US2005/010466 WO2005099761A1 (en) | 2004-04-07 | 2005-03-28 | Dietary supplement and method of processing same |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007532543A JP2007532543A (ja) | 2007-11-15 |
JP4963670B2 true JP4963670B2 (ja) | 2012-06-27 |
Family
ID=35149781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007507358A Expired - Fee Related JP4963670B2 (ja) | 2004-04-07 | 2005-03-28 | 栄養補助サプリメントおよびそれを処理する方法 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1735004A4 (ja) |
JP (1) | JP4963670B2 (ja) |
KR (1) | KR101213141B1 (ja) |
CN (1) | CN1956733B (ja) |
WO (1) | WO2005099761A1 (ja) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103055313A (zh) * | 2005-07-07 | 2013-04-24 | 西特里斯药业公司 | 用于治疗或预防肥胖、胰岛素抵抗障碍和线粒体相关障碍的方法和相关组合物 |
WO2007096078A1 (en) * | 2006-02-24 | 2007-08-30 | Dsm Ip Assets B.V. | Use of resveratrol and derivatives thereof for promoting the wellness state in mammals |
DE102007011676A1 (de) * | 2007-03-09 | 2008-09-18 | Hermann-Josef Wilhelm | Verfahren zur Herstellung von Wirkstoffen aus einer Pflanze |
JP2010540444A (ja) * | 2007-09-20 | 2010-12-24 | レスベラトロル パートナーズ, エルエルシー | 遺伝子産物の濃縮または活性を調節するためのレスベラトロールを含む組成物 |
US20090163580A1 (en) * | 2007-12-24 | 2009-06-25 | Natrol, Inc. | Anti-aging composition containing resveratrol and method of administration |
DE102008035285A1 (de) * | 2008-07-02 | 2010-01-07 | Hermann-Josef Wilhelm | Verfahren zur Gewinnung von Wirkstoffen aus einer Pflanze |
US9173916B2 (en) | 2008-07-31 | 2015-11-03 | Shaklee Corporation | Method of preparing a muscadine pomace extract |
JP5608646B2 (ja) * | 2008-07-31 | 2014-10-15 | シャクリー コーポレーション | 向上した抗酸化活性を有するマスカダイン組成物 |
US9132162B2 (en) | 2008-07-31 | 2015-09-15 | Shaklee Corporation | Muscadine compositions with anti-oxidant activity |
CN102164607B (zh) | 2008-07-31 | 2013-04-24 | 嘉康利公司 | 麝香葡萄果渣提取物的制备方法 |
TWI448250B (zh) * | 2008-07-31 | 2014-08-11 | Shaklee Corp | 具有改良的抗氧化劑活性的麝香葡萄組成物 |
DE102008037337A1 (de) * | 2008-08-11 | 2010-02-25 | Hermann-Josef Wilhelm | Verfahren zur Herstellung von Wirkstoffen, insbesondere Phenolen aus einer Pflanze |
JP5916321B2 (ja) * | 2011-09-05 | 2016-05-11 | 株式会社山田養蜂場本社 | トランスレスベラトロール含有組成物 |
WO2013074948A1 (en) | 2011-11-16 | 2013-05-23 | Resveratrol Partners, Llc | Compositions containing resveratrol and nucleotides |
US10335433B2 (en) * | 2013-04-10 | 2019-07-02 | Mimedx Group, Inc. | NDGA polymers and metal complexes thereof |
JP6343126B2 (ja) * | 2013-05-14 | 2018-06-13 | 森永製菓株式会社 | 植物抽出物またはその溶液に含まれるスチルベン類の安定化方法、及び、スチルベン類を含有した植物抽出物またはその溶液 |
JP6209360B2 (ja) * | 2013-05-14 | 2017-10-04 | 森永製菓株式会社 | ピセアタンノール溶液、及び、ピセアタンノール溶液の安定化方法 |
US9446142B2 (en) * | 2013-05-28 | 2016-09-20 | Mimedx Group, Inc. | Polymer chelator conjugates |
MY196365A (en) | 2016-07-19 | 2023-03-27 | Shaklee Corp | Muscadine Topical Composition with Low Content of Condensed Tannin Molecules |
KR101990060B1 (ko) | 2017-07-21 | 2019-09-30 | 주식회사 송이산업 | 레스베라트롤의 나노캡슐 제조방법 및 제조된 레스베라트롤 나노캡슐 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2560051B2 (ja) * | 1987-12-11 | 1996-12-04 | 扶桑薬品工業株式会社 | 遮光性カプセル製剤 |
US4963385A (en) * | 1989-06-02 | 1990-10-16 | Nabisco Brands, Inc. | Stabilized emulsions containing highly unsaturated oils |
US6184248B1 (en) * | 1996-09-05 | 2001-02-06 | Robert K. K. Lee | Compositions and methods for treatment of neurological disorders and neurodegenerative diseases |
PL332306A1 (en) * | 1996-09-20 | 1999-08-30 | Howard Foundation | Method of obtaining composition containing polyphenoles |
DE19714450A1 (de) * | 1997-04-08 | 1998-10-15 | Schwabe Willmar Gmbh & Co | Stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und pharmazeutische Zubereitung |
CN100379419C (zh) * | 1997-07-11 | 2008-04-09 | 东丽株式会社 | 含有4,5-环氧***喃衍生物的稳定的药物组合物 |
US6190716B1 (en) * | 1999-02-17 | 2001-02-20 | Scott O. Galbreath, Jr. | Method for preparing a grape derived product |
US6251478B1 (en) * | 1999-12-22 | 2001-06-26 | Balchem Corporation | Sensitive substance encapsulation |
US20030044474A1 (en) * | 2001-08-03 | 2003-03-06 | Shaklee Corporation | High molecular weight, lipophilic, orally ingestible bioactive agents in formulations having improved bioavailability |
JP2003119127A (ja) * | 2001-10-10 | 2003-04-23 | Kanegafuchi Chem Ind Co Ltd | 安定な還元型補酵素q製剤 |
US20030133945A1 (en) * | 2002-01-11 | 2003-07-17 | Farley Michael Donald | Natural food supplement |
NZ536267A (en) * | 2002-04-10 | 2007-06-29 | Fred H Miller | Multi-phase, multi-compartment and multi-ingredient capsular system |
GB2408729A (en) * | 2002-09-04 | 2005-06-08 | Southwest Res Inst | Microencapsulation of oxygen or water sensitive materials |
PL2218342T3 (pl) * | 2003-05-27 | 2019-01-31 | Dsm Ip Assets B.V. | Nowe kompozycje nutraceutyczne i ich zastosowanie |
-
2005
- 2005-03-28 WO PCT/US2005/010466 patent/WO2005099761A1/en not_active Application Discontinuation
- 2005-03-28 EP EP05731006A patent/EP1735004A4/en not_active Withdrawn
- 2005-03-28 JP JP2007507358A patent/JP4963670B2/ja not_active Expired - Fee Related
- 2005-03-28 CN CN2005800107544A patent/CN1956733B/zh not_active Expired - Fee Related
-
2006
- 2006-10-02 KR KR1020067020587A patent/KR101213141B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR101213141B1 (ko) | 2012-12-17 |
EP1735004A4 (en) | 2011-11-09 |
KR20070041427A (ko) | 2007-04-18 |
WO2005099761A1 (en) | 2005-10-27 |
CN1956733B (zh) | 2012-10-10 |
EP1735004A1 (en) | 2006-12-27 |
CN1956733A (zh) | 2007-05-02 |
JP2007532543A (ja) | 2007-11-15 |
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