JP4949898B2 - 血球分析装置 - Google Patents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/012—Red blood cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/012—Red blood cells
- G01N2015/014—Reticulocytes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/018—Platelets
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
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- G—PHYSICS
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Description
<式1>
RET−He=A×exp(B×RET−Y)
(ただし、A=5.8439、B=0.0098)
<式2>
RBC−He=C×exp(D×RBC−Y)
(ただし、C=5.8439、D=0.0098)
さらに、算出した値(RET−He)から値(RBC−He)を引算し、両者の差を表す値(Delta−He)を算出する(ステップS5)。
3 血球分析装置のデータ処理部
4 検出部
7 表示・操作部
8 装置機構部
64 データ分析部
81 流体機構部
100 データ処理部の表示画面
104 フラグ表示領域
A1〜A9、A、B、C、D 区分け領域
Claims (5)
- 血液試料に光を照射して血液試料に含まれる各細胞から少なくとも散乱光情報を含む光学的情報を取得する検出部と、
取得された光学的情報に基づいて前記細胞のうち赤血球および網状赤血球を分類し、赤血球に関する散乱光情報である赤血球散乱光情報および網状赤血球に関する散乱光情報である網状赤血球散乱光情報を取得し、赤血球散乱光情報から赤血球中のヘモグロビン量相当値を取得し、網状赤血球散乱光情報から網状赤血球中のヘモグロビン量相当値を取得し、網状赤血球中ヘモグロビン量相当値と赤血球中ヘモグロビン量相当値との差(ヘモグロビン量差)を取得し、前記網状赤血球中ヘモグロビン量相当値および前記ヘモグロビン量差に基づいて臨床検査支援情報を取得するデータ分析部と、
データ分析部により取得された臨床検査支援情報を出力する出力部と、を備え、
前記データ分析部は、網状赤血球中ヘモグロビン量相当値とヘモグロビン量差をパラメータとし、臨床的意義情報に対応した複数の領域が設定された相関図を記憶する記憶手段を備えており、前記記憶手段から読み出した相関図に、前記網状赤血球中ヘモグロビン量相当値および前記ヘモグロビン量差のデータを検体分析情報としてプロットし、かつ、前記検体分析情報の測定日を前記プロットと共に表示した相関図を臨床検査支援情報として取得する、血球分析装置。 - 前記記憶手段は、検体分析情報がプロットされた相関図を検体属性情報とともに記憶し、支援情報取得手段は、前記記憶手段に記憶された相関図の検体属性情報と同じ検体属性情報を有する血液試料を分析した場合、前記記憶手段から読み出した相関図に、得られた網状赤血球中ヘモグロビン量相当値およびヘモグロビン量差のデータを第2検体分析情報としてプロットし、かつ、前記第2検体分析情報の測定日を前記プロットと共に表示する請求項1に記載の血球分析装置。
- 赤血球散乱光情報が各赤血球の散乱光強度の平均値であり、網状赤血球散乱光情報が各網状赤血球の散乱光強度の平均値である請求項1または請求項2に記載の血球分析装置。
- 前記記憶手段に記憶された相関図は、臨床的意義情報に対応した複数の領域として、少なくとも正色素性赤血球における正常なヘモグロビン合成状態を示す領域、高色素性赤血球における正常なヘモグロビン合成状態を示す領域、潜在的鉄欠乏あるいは急性の感染症や炎症反応における機能上の鉄欠乏状態を示す領域、および、鉄欠乏あるいは慢性の感染症や炎症反応における機能上の鉄欠乏状態を示す領域を含む請求項1〜3の何れか1項に記載の血球分析装置。
- 血液試料に光を照射して血液試料に含まれる各細胞から少なくとも散乱光情報を含む光学的情報を取得するステップ、
取得された光学的情報に基づいて前記細胞のうち赤血球および網状赤血球を分類するステップ、
赤血球に関する散乱光情報である赤血球散乱光情報および網状赤血球に関する散乱光情報である網状赤血球散乱光情報を取得するステップ、
赤血球散乱光情報から赤血球中のヘモグロビン量相当値を取得し、網状赤血球散乱光情報から網状赤血球中のヘモグロビン量相当値を取得するステップ、
赤血球中ヘモグロビン量相当値と網状赤血球中ヘモグロビン量相当値との差(ヘモグロビン量差)を取得するステップ、
網状赤血球中ヘモグロビン量相当値およびヘモグロビン量差に基づいて臨床検査支援情報を取得するステップ、および、
取得した臨床検査支援情報を出力するステップ、からなり、
前記臨床検査支援情報取得ステップは、網状赤血球中ヘモグロビン量相当値とヘモグロビン量差をパラメータとし、臨床的意義情報に対応した複数の領域が設定された相関図に、前記網状赤血球中ヘモグロビン量相当値および前記ヘモグロビン量差のデータを検体分析情報としてプロットし、かつ、前記検体分析情報の測定日を前記プロットと共に表示し、前記データのプロット及び前記測定日の行われた相関図を臨床検査支援情報として取得する、血球分析方法。
Priority Applications (3)
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JP2007061093A JP4949898B2 (ja) | 2007-03-09 | 2007-03-09 | 血球分析装置 |
EP08003550.4A EP1967840A3 (en) | 2007-03-09 | 2008-02-27 | Hematology analyzer, hematology analyzing method, and computer program product |
US12/044,780 US20080268494A1 (en) | 2007-03-09 | 2008-03-07 | Hematology analyzer, hematology analyzing method, and computer program product |
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Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2759392A1 (en) | 2009-04-27 | 2010-11-04 | Abbott Laboratories | Method for discriminating red blood cells from white blood cells by using forward scattering from a laser in an automated hematology analyzer |
US8911669B2 (en) | 2009-08-24 | 2014-12-16 | Abbott Laboratories | Method for flagging a sample |
JP5530691B2 (ja) * | 2009-09-25 | 2014-06-25 | シスメックス株式会社 | 血球計数装置、診断支援装置、診断支援方法及びコンピュータプログラム |
JP5667353B2 (ja) * | 2009-09-25 | 2015-02-12 | シスメックス株式会社 | 血球計数装置、診断支援装置、診断支援方法及びコンピュータプログラム |
WO2011044665A1 (en) * | 2009-10-16 | 2011-04-21 | Canadian Blood Services | Dual analyzer system for biological fluid |
US8906308B2 (en) | 2010-01-15 | 2014-12-09 | Abbott Laboratories | Method for determining volume and hemoglobin content of individual red blood cells |
FR2956207B1 (fr) | 2010-02-10 | 2012-05-04 | Horiba Abx Sas | Dispositif et procede de mesures multiparametriques de microparticules dans un fluide |
WO2012037524A2 (en) | 2010-09-16 | 2012-03-22 | The General Hospital Corporation | Red blood cell dynamics for diagnosis |
US9005909B2 (en) | 2011-01-06 | 2015-04-14 | Rigel Pharmaceuticals, Inc. | Whole blood assay for measuring AMPK activation |
US10514385B2 (en) | 2011-07-22 | 2019-12-24 | Sysmex Corporation | Hematology analyzer, method, and system for quality control measurements |
US9297819B2 (en) * | 2011-07-22 | 2016-03-29 | Sysmex Corporation | Hematology analyzing system and analyzer |
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CN104458541A (zh) * | 2013-09-12 | 2015-03-25 | 深圳迈瑞生物医疗电子股份有限公司 | 红细胞血红蛋白含量的分析方法、装置及血液细胞分析仪 |
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