JP4911398B2 - bandage - Google Patents
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- JP4911398B2 JP4911398B2 JP2005230356A JP2005230356A JP4911398B2 JP 4911398 B2 JP4911398 B2 JP 4911398B2 JP 2005230356 A JP2005230356 A JP 2005230356A JP 2005230356 A JP2005230356 A JP 2005230356A JP 4911398 B2 JP4911398 B2 JP 4911398B2
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- bandage
- fibers
- zinc
- present
- dressing
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- 229920003043 Cellulose fiber Polymers 0.000 claims description 49
- 125000004181 carboxyalkyl group Chemical class 0.000 claims description 22
- 238000006467 substitution reaction Methods 0.000 claims description 17
- 230000001954 sterilising effect Effects 0.000 claims description 13
- 238000004659 sterilization and disinfection Methods 0.000 claims description 12
- 229910052725 zinc Inorganic materials 0.000 claims description 11
- 239000011701 zinc Substances 0.000 claims description 11
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 description 32
- 238000000034 method Methods 0.000 description 21
- 239000000835 fiber Substances 0.000 description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- 229910052751 metal Inorganic materials 0.000 description 15
- 239000002184 metal Substances 0.000 description 15
- 238000012360 testing method Methods 0.000 description 15
- 238000011282 treatment Methods 0.000 description 14
- 241000894006 Bacteria Species 0.000 description 13
- 238000010521 absorption reaction Methods 0.000 description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 239000002253 acid Substances 0.000 description 9
- 229910052783 alkali metal Inorganic materials 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 239000004744 fabric Substances 0.000 description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 6
- 150000001340 alkali metals Chemical class 0.000 description 6
- 210000000416 exudates and transudate Anatomy 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000003960 organic solvent Substances 0.000 description 6
- 230000028327 secretion Effects 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 229920002678 cellulose Polymers 0.000 description 5
- 239000001913 cellulose Substances 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000012046 mixed solvent Substances 0.000 description 5
- 239000002504 physiological saline solution Substances 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 238000007654 immersion Methods 0.000 description 4
- 238000009940 knitting Methods 0.000 description 4
- 150000002736 metal compounds Chemical class 0.000 description 4
- 229910021645 metal ion Inorganic materials 0.000 description 4
- 235000019645 odor Nutrition 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 229920000297 Rayon Polymers 0.000 description 3
- 229910021536 Zeolite Inorganic materials 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000003749 cleanliness Effects 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000004332 deodorization Methods 0.000 description 3
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 239000004745 nonwoven fabric Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- FDRCDNZGSXJAFP-UHFFFAOYSA-M sodium chloroacetate Chemical compound [Na+].[O-]C(=O)CCl FDRCDNZGSXJAFP-UHFFFAOYSA-M 0.000 description 3
- 239000010457 zeolite Substances 0.000 description 3
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 3
- 229960001763 zinc sulfate Drugs 0.000 description 3
- 229910000368 zinc sulfate Inorganic materials 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- -1 carboxyethyl group Chemical group 0.000 description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 2
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- QKSIFUGZHOUETI-UHFFFAOYSA-N copper;azane Chemical compound N.N.N.N.[Cu+2] QKSIFUGZHOUETI-UHFFFAOYSA-N 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 230000001877 deodorizing effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 2
- 239000002964 rayon Substances 0.000 description 2
- 239000001632 sodium acetate Substances 0.000 description 2
- 235000017281 sodium acetate Nutrition 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002759 woven fabric Substances 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- GAWAYYRQGQZKCR-UHFFFAOYSA-N 2-chloropropionic acid Chemical compound CC(Cl)C(O)=O GAWAYYRQGQZKCR-UHFFFAOYSA-N 0.000 description 1
- QEYMMOKECZBKAC-UHFFFAOYSA-N 3-chloropropanoic acid Chemical compound OC(=O)CCCl QEYMMOKECZBKAC-UHFFFAOYSA-N 0.000 description 1
- 229920002972 Acrylic fiber Polymers 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920000433 Lyocell Polymers 0.000 description 1
- 229920001407 Modal (textile) Polymers 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 229920002978 Vinylon Polymers 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 description 1
- 238000010306 acid treatment Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000004760 aramid Substances 0.000 description 1
- 229920006231 aramid fiber Polymers 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 229940106681 chloroacetic acid Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- WBJINCZRORDGAQ-UHFFFAOYSA-N ethyl formate Chemical compound CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- JDNTWHVOXJZDSN-UHFFFAOYSA-N iodoacetic acid Chemical compound OC(=O)CI JDNTWHVOXJZDSN-UHFFFAOYSA-N 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 230000005722 itchiness Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920006306 polyurethane fiber Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 229920002620 polyvinyl fluoride Polymers 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000004627 regenerated cellulose Substances 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
- RZLVQBNCHSJZPX-UHFFFAOYSA-L zinc sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Zn+2].[O-]S([O-])(=O)=O RZLVQBNCHSJZPX-UHFFFAOYSA-L 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Description
本発明は、医療分野において治療や処置のために皮膚又はその他の体表面を被覆し、人体からの分泌液や滲出液等を処理したり、菌の増殖を抑制したりして、皮膚を衛生的な状態に保つ包帯に関する。特に、本発明は、ギプス、キャスト、スプリント、装具等の外固定材の下巻き用包帯として、又は手術部位の周りを覆うドレープとして使用する包帯に関する。 The present invention covers the skin or other body surface for medical treatment or treatment in the medical field, treats the secretion or exudate from the human body, suppresses the growth of bacteria, and hygienizes the skin. It is related to the bandage which keeps it in a state. In particular, the present invention relates to a bandage used as a lower wrapping bandage for external fixation materials such as casts, casts, sprints, and orthoses, or as a drape covering a surgical site.
従来から、創傷や疾病の治療や処置に、所謂、ガーゼ包帯、布帛包帯、巻軸包帯、粘着包帯等の各種包帯が使用されている。包帯の基本的な機能としては、被覆（保護）、圧迫、固定、牽引、水分の吸収等があり、対象となる患部に直接又は間接的に当てて使用される。
包帯の適用に当たっては、患部への菌浸入を防止する必要があり、包帯の使用に際しては、包帯を適用する患部を消毒したり、包帯自体を滅菌したりする処置がなされている。
Conventionally, various bandages such as so-called gauze bandages, fabric bandages, wound bandages and adhesive bandages have been used for the treatment and treatment of wounds and diseases. The basic functions of the bandage include covering (protection), compression, fixation, traction, moisture absorption, and the like, which are used directly or indirectly on the affected area.
In applying the bandage, it is necessary to prevent bacteria from entering the affected area. When the bandage is used, treatments are performed such as disinfecting the affected area to which the bandage is applied or sterilizing the bandage itself.
包帯が皮膚に長期間適用される場合は、皮膚からの分泌液、滲出液、落屑等により皮膚表面に菌が増殖し易くなり、更に外部からの汚染の可能性も高まる。このような感染のリスク等を低減するため、患部の洗浄や包帯の交換が頻繁に行われる。
また、骨折、捻挫及び脱臼の治療や、四肢の機能の補助又は変形の予防等に使用されるギプス、キャスト、スプリント等のような外固定材を適用する場合、外固定材を装着する前に下巻き用包帯が皮膚に被覆されて、外固定材と皮膚との摩擦を緩衝し、人体からの分泌液、滲出液等を吸収する役割を果たす。この場合、皮膚上に閉鎖環境が作り出され、治療の必要性からそれが長期間続くことが多いが、上記のような患部の洗浄や包帯の交換を頻繁に行うことは不可能である。このため、汗や垢により皮膚表面で菌が繁殖し、また、臭いや痒みが発生し易いという問題がある。更に、皮膚に傷や術後創がある場合には、感染を引き起こす恐れがある。
When the bandage is applied to the skin for a long period of time, bacteria are likely to grow on the skin surface due to secretions, exudates, desquamation, etc. from the skin, and the possibility of contamination from the outside increases. In order to reduce the risk of such infection, etc., the affected area is frequently washed and bandages are replaced.
In addition, when applying external fixation materials such as casts, casts, sprints, etc. used to treat fractures, sprains and dislocations, assist limb functions or prevent deformation, etc. The lower wrapping bandage is coated on the skin to buffer the friction between the external fixing material and the skin, and to absorb secretions, exudates, etc. from the human body. In this case, a closed environment is created on the skin, and it often lasts for a long time due to the necessity of treatment. However, it is impossible to frequently perform cleaning of the affected part and replacement of the bandage as described above. For this reason, there are problems that bacteria grow on the skin surface due to sweat and dirt, and that odors and itchiness tend to occur. In addition, if there is a wound or postoperative wound on the skin, it may cause infection.
従って、患部の洗浄や包帯の交換の頻度を下げ、且つ、皮膚表面等における菌の繁殖を防ぎ、臭いやかゆみの発生を防ぐことができる包帯が求められている。
また、包帯の適用中に、分泌液、滲出液等の吸収や外部からの汚染等があった場合は、速やかに交換をする必要があるが、交換の必要時期を容易に感知することができる包帯が求められている。
また、手術の際に飛散する血液、体液、生理食塩水等の液体から術野周囲の汚染を防ぎ、患者への感染を予防する観点から、患者を被覆し、術野のみを露出させるドレープが用いられている。この場合にも、簡便な処置で菌の繁殖を防ぐことができ、容易に交換の必要性を感知できることが求められている。
Accordingly, there is a need for a bandage that can reduce the frequency of washing the affected area and changing the bandage, prevent the growth of bacteria on the skin surface, etc., and prevent the generation of odor and itching.
In addition, if there is absorption of secretions, exudates, etc. or contamination from the outside during application of the bandage, it is necessary to replace it quickly, but it is possible to easily detect when the replacement is necessary. Bandages are sought.
In addition, a drape that covers the patient and exposes only the surgical field from the viewpoint of preventing contamination around the surgical field from blood, body fluid, physiological saline, and other liquids scattered during the operation, and preventing infection to the patient. It is used. In this case as well, it is required that the propagation of bacteria can be prevented with a simple treatment and the necessity for replacement can be easily detected.
特許文献１には、疎水性繊維ウェブと活性炭粒子を含有するシートとを積層させ、疎水性繊維ウェブが活性炭粒子含有シートに貫入されている臭い吸収用ウェブが開示されている。この臭い吸収用ウェブは、ギプスの下巻き用として使用される。
この吸収用ウェブは、臭気に対しては良好な消臭効果を有するが、菌の繁殖を抑制することはできない。また、活性炭により黒い外観になるため、汚れの付着や、吸収した体液の色等を観察することが難しく、交換の必要性を容易に感知することができない。
Patent Document 1 discloses an odor absorbing web in which a hydrophobic fiber web and a sheet containing activated carbon particles are laminated, and the hydrophobic fiber web is penetrated into the activated carbon particle-containing sheet. This odor-absorbing web is used as a lower roll for a cast.
This absorbent web has a good deodorizing effect on odor, but cannot suppress the growth of bacteria. Further, since the black appearance is caused by activated carbon, it is difficult to observe the adhesion of dirt, the color of the absorbed body fluid, and the like, and the necessity for replacement cannot be easily detected.
特許文献２には、銀、銅又は亜鉛イオンを担持するゼオライトを含有する合成繊維を含む、ギプス下巻き用不織布が開示されている。しかしながら、ゼオライトのような粒体は、使用中にゼオライトが繊維から脱落する可能性があり、抗菌性の持続性に問題がある。 Patent Document 2 discloses a nonwoven fabric for undercast casting including synthetic fibers containing zeolite carrying silver, copper or zinc ions. However, granules such as zeolite have a problem in antibacterial durability because zeolite may fall out of the fiber during use.
本発明は、このような状況の下になされたものであって、長期間に亘って皮膚表面等における菌の繁殖を防ぐことができ、他方、交換の必要性を容易に感知できる包帯を提供することを目的とする。 The present invention has been made under such circumstances, and provides a bandage that can prevent the growth of bacteria on the surface of the skin over a long period of time and can easily sense the necessity of replacement. The purpose is to do.
本発明者らは、鋭意検討を進めた結果、特定の構造を有するカルボキシアルキル化セルロース繊維を含んでなる包帯を用いれば、上記目的が達成されることを見出し、この知見に基づいて更に検討を進めて、本発明を完成するに至った。 As a result of diligent investigations, the present inventors have found that the above object can be achieved by using a bandage comprising a carboxyalkylated cellulose fiber having a specific structure, and further studies are made based on this finding. The present invention has been completed.
かくして、本発明によれば、表面の少なくとも一部に、カルボキシアルキル基の少なくとも一部が抗菌性金属カルボキシアルキル基で置換されているカルボキシアルキル化セルロース繊維を含んでなる包帯が提供される。
本発明の包帯は、高圧蒸気滅菌後のＬ＊ａ＊ｂ＊表色系によるＬ＊が＋８０〜＋１００、ａ＊が−１０〜＋１０、ｂ＊が−１０〜＋１０であることが好ましく、白色であることが更に好ましい。
更に、本発明の包帯は、好適には、高圧蒸気滅菌前後のＬ＊ａ＊ｂ＊表色系による色差（ΔＥ＊ａｂ）が１０以下であり、また、高圧蒸気滅菌前後の色の変化が肉眼で識別できないものであることが好ましい。
本発明の包帯において、カルボキシアルキル基の抗菌性金属カルボキシアルキル基による平均置換度が０．０１〜０．３であることが好ましい。
また、本発明の包帯において、抗菌性金属が亜鉛であることが好ましい。
また、本発明の包帯は、好適には、湿潤時の引張強度が１０〜５００Ｎ／５０ｍｍである。
本発明の包帯は、チューブ状であってもよい。
Thus, according to the present invention there is provided a bandage comprising carboxyalkylated cellulose fibers having at least a portion of the surface substituted with at least a portion of carboxyalkyl groups with antimicrobial metal carboxyalkyl groups.
The dressing according to the present invention preferably has an L * of +80 to +100, an a * of −10 to +10, and a b * of −10 to +10 according to the L * a * b * color system after high-pressure steam sterilization. More preferably.
Furthermore, the dressing of the present invention preferably has a color difference (ΔE * ab) of 10 or less according to the L * a * b * color system before and after autoclaving, and the color change before and after autoclaving is high. It is preferable that it cannot be identified with the naked eye.
In the dressing of the present invention, the average degree of substitution of the carboxyalkyl group with the antibacterial metal carboxyalkyl group is preferably 0.01 to 0.3.
In the bandage of the present invention, the antibacterial metal is preferably zinc.
The bandage of the present invention preferably has a tensile strength when wet of 10 to 500 N / 50 mm.
The bandage of the present invention may be tubular.
本発明によれば、表面の少なくとも一部に、亜鉛カルボキシアルキル基によるカルボキシアルキル基の平均置換度が０．０１〜０．３であるカルボキシアルキル化セルロース繊維を含んでなり、高圧蒸気滅菌後のＬ＊ａ＊ｂ＊表色系によるＬ＊が＋８０〜＋１００、ａ＊が−１０〜＋１０、ｂ＊が−１０〜＋１０であるチューブ状包帯が提供される。
また、本発明によれば、表面の少なくとも一部に、亜鉛カルボキシアルキル基によるカルボキシアルキル基の平均置換度が０．０１〜０．３であるカルボキシアルキル化セルロース繊維を含んでなり、高圧蒸気滅菌前後のＬ＊ａ＊ｂ＊表色系による色差（ΔＥ＊ａｂ）が１０以下であるチューブ状包帯が提供される。
本発明の包帯は、滅菌処理を施したものであることが好ましい。
According to the present invention, at least a part of the surface comprises carboxyalkylated cellulose fibers having an average degree of substitution of carboxyalkyl groups by zinc carboxyalkyl groups of 0.01 to 0.3, and after autoclaving A tube dressing is provided in which L * is +80 to +100, a * is −10 to +10, and b * is −10 to +10 according to the L * a * b * color system.
Further, according to the present invention, at least a part of the surface comprises carboxyalkylated cellulose fibers having an average degree of substitution of carboxyalkyl groups by zinc carboxyalkyl groups of 0.01 to 0.3, and is subjected to high-pressure steam sterilization. A tubular bandage having a color difference (ΔE * ab) of 10 or less according to the front and rear L * a * b * color system is provided.
The bandage of the present invention is preferably sterilized.
本発明の包帯は、抗菌性に優れ、淡色であるので、感染のリスクを長期間に亘って低減することができ、交換の必要時期を容易に感知できる。
本発明の包帯は、外固定材の下巻き用の包帯として、また、手術部位の周りを覆うドレープとして、更には、その他の医療処置で長期間又は高度の衛生管理が求められる場合に患部の被覆や吸収等を行う汎用衛生材料として、有用である。
Since the bandage of the present invention is excellent in antibacterial properties and is light in color, the risk of infection can be reduced over a long period of time, and the time required for replacement can be easily detected.
The bandage of the present invention is used as a lower bandage for an external fixing material, as a drape covering the surgical site, or when a long-term or high-level hygiene management is required for other medical procedures. It is useful as a general-purpose sanitary material for coating and absorption.
本発明の包帯は、カルボキシアルキル化セルロース繊維を含んでなる。
カルボキシアルキル化セルロース繊維は、セルロース繊維の有する水酸基をカルボキシアルキル化したものである。即ち、セルロース繊維の有する水酸基をカルボキシアルキル基に変換したものである。カルボキシアルキル基は、特に限定されないが、カルボキシメチル基、カルボキシエチル基等を例示することができる。
セルロース繊維は、特に限定されず、その具体例としては、綿等の天然セルロース繊維；ビスコースレーヨン繊維、ポリノジック繊維や銅アンモニアレーヨン繊維、リヨセル繊維、モダル繊維等の再生セルロース繊維が挙げられる。
セルロース繊維は、包帯中に５０〜１００重量％含まれていることが好ましく、７０〜１００重量％含まれていることが更に好ましい。セルロース繊維の比率が上記範囲内にあることにより、包帯に良好な吸湿性、吸水性及び肌触りを付与することができる。
セルロース繊維のカルボキシアルキル化の程度は、セルロース繊維を構成するセルロースの無水グルコース単位当たりのカルボキシアルキル基のモル数（平均置換度）が、好ましくは０．０１〜０．３、更に好ましくは０．０１〜０．１となる範囲である。
セルロース繊維のカルボキシアルキル化は、従来公知の方法によればよく、特に限定されない。
The bandage of the present invention comprises carboxyalkylated cellulose fibers.
The carboxyalkylated cellulose fiber is obtained by carboxyalkylating the hydroxyl group of the cellulose fiber. That is, the hydroxyl group of cellulose fiber is converted to a carboxyalkyl group. Although a carboxyalkyl group is not specifically limited, A carboxymethyl group, a carboxyethyl group, etc. can be illustrated.
The cellulose fiber is not particularly limited, and specific examples thereof include natural cellulose fibers such as cotton; regenerated cellulose fibers such as viscose rayon fiber, polynosic fiber, copper ammonia rayon fiber, lyocell fiber, and modal fiber.
Cellulose fibers are preferably contained in the bandage in an amount of 50 to 100% by weight, and more preferably 70 to 100% by weight. When the ratio of the cellulose fiber is within the above range, the bandage can be given good hygroscopicity, water absorption and touch.
The degree of carboxyalkylation of the cellulose fibers is such that the number of moles of carboxyalkyl groups (an average substitution degree) per anhydroglucose unit of cellulose constituting the cellulose fibers is preferably 0.01 to 0.3, more preferably 0.8. It is the range which becomes 01-0.1.
The carboxyalkylation of the cellulose fiber may be performed by a conventionally known method and is not particularly limited.
本発明において、カルボキシアルキル化セルロース繊維のカルボキシアルキル基の少なくとも一部が抗菌性金属カルボキシアルキル基で置換されていることが必要である。これにより、本発明の包帯は良好な抗菌・消臭機能を発揮する。
抗菌性金属カルボキシアルキル基は、カルボキシアルキル基のカルボキシ水素を抗菌性金属で置換したものである。
抗菌性金属は、特に限定されないが、高圧蒸気滅菌後の包帯の色が白色であることから、亜鉛が好ましい。
抗菌性金属カルボキシアルキル基の量は、セルロース繊維を構成するセルロースの無水グルコース単位当たりの抗菌性金属カルボキシアルキル基のモル数（平均置換度）が、好ましくは０．０１〜０．３、更に好ましくは０．０１〜０．１となる範囲である。
平均置換度が０．０１〜０．３の範囲内であると、高圧蒸気滅菌による変色の度合いが少なく、また、高圧蒸気滅菌後も淡色であり、更に、肌接触材料としての風合いを維持し得るので好ましい。
In the present invention, it is necessary that at least a part of the carboxyalkyl group of the carboxyalkylated cellulose fiber is substituted with an antibacterial metal carboxyalkyl group. Thereby, the bandage of this invention exhibits a favorable antibacterial / deodorant function.
The antibacterial metal carboxyalkyl group is obtained by replacing the carboxy hydrogen of the carboxyalkyl group with an antibacterial metal.
The antibacterial metal is not particularly limited, but zinc is preferable because the bandage color after high-pressure steam sterilization is white.
The amount of the antibacterial metal carboxyalkyl group is such that the number of moles of the antibacterial metal carboxyalkyl group (an average substitution degree) per anhydroglucose unit of cellulose constituting the cellulose fiber is preferably 0.01 to 0.3, and more preferably. Is in the range of 0.01 to 0.1.
If the average degree of substitution is in the range of 0.01 to 0.3, the degree of discoloration due to high-pressure steam sterilization is small, the color is still light after high-pressure steam sterilization, and the texture as a skin contact material is maintained. This is preferable.
セルロース繊維の抗菌性金属カルボキシアルキル化は、セルロース繊維をアルカリ金属カルボキシアルキル化した後、金属イオン交換反応によって、アルカリ金属を抗菌性金属に変換することによって得ることができる。
セルロース繊維をアルカリ金属カルボキシアルキル化する方法は、従来公知の方法を採用すればよく、例えば、以下のようにして行うことが出来る。
セルロース繊維を、クロロ酢酸、ブロモ酢酸、ヨード酢酸、１−クロロプロピオン酸、２−クロロプロピオン酸、３−クロロプロピオン酸等の炭素数２〜３のハロゲノアルカン酸もしくはその塩（以下、両者を合わせて単に「ハロゲノアルカン酸等」という。）又はハロゲノアルカン酸等と水酸化アルカリ金属との混合溶液（以下、単に「浸漬液」という。）に浸漬する。浸漬は、浸漬液を入れた浴にカルボキシアルキル化処理前のセルロース繊維を漬けることによって行うことができる。ハロゲノアルカン酸としては、一般的にモノクロロ酢酸又はその塩が用いられ、水酸化アルカリ金属としては、好ましくは水酸化ナトリウムが用いられる。ハロゲノアルカン酸等又はこれと水酸化アルカリ金属との混合溶液を調製するために、溶媒としては水、アルコール等の有機溶媒、又は水と有機溶媒との混合溶媒が用いられる。又はロゲノアルカン酸等の濃度は、所望のカルボキシアルキル基平均置換度に応じて適宜決定すればよい。
The antibacterial metal carboxyalkylation of the cellulose fiber can be obtained by converting the alkali metal to the antibacterial metal by a metal ion exchange reaction after the cellulose fiber is alkali metal carboxyalkylated.
As a method for alkali metal carboxyalkylating cellulose fibers, a conventionally known method may be adopted, and for example, it can be performed as follows.
Cellulose fibers are made of halogenoalkanoic acid having 2 to 3 carbon atoms such as chloroacetic acid, bromoacetic acid, iodoacetic acid, 1-chloropropionic acid, 2-chloropropionic acid, and 3-chloropropionic acid, or a salt thereof (hereinafter, both are combined). Simply dipping in a mixed solution of halogenoalkanoic acid or the like and an alkali metal hydroxide (hereinafter simply referred to as “immersion liquid”). Immersion can be performed by immersing the cellulose fiber before the carboxyalkylation treatment in a bath containing an immersion liquid. Monochloroacetic acid or a salt thereof is generally used as the halogenoalkanoic acid, and sodium hydroxide is preferably used as the alkali metal hydroxide. In order to prepare a halogenoalkanoic acid or the like or a mixed solution of this and an alkali metal hydroxide, an organic solvent such as water or alcohol, or a mixed solvent of water and an organic solvent is used as the solvent. Alternatively, the concentration of logenoalkanoic acid or the like may be appropriately determined according to the desired average degree of carboxyalkyl group substitution.
次に、カルボキシアルキル化処理前のセルロース繊維の浸漬液含浸量を、圧搾又は遠心脱水により調整した後、セルロース繊維を加熱処理する。加熱処理は、通常、熱風、電気ヒーター、赤外線ヒーター等の熱風循環式乾燥機等を用いて行えばよい。加熱処理の温度は、通常、１００℃〜２００℃で、加熱処理の時間は、通常、１５秒ないし３０分間程度である。この加熱処理によって、セルロース繊維中のセルロース分子がハロゲノアルカン酸等と又は更に水酸化アルカリ金属と反応して、セルロース分子の水酸基の水素原子がカルボキシアルキル基又はアルカリ金属カルボキシアルキル基と置換される。 Next, after adjusting the immersion liquid impregnation amount of the cellulose fiber before the carboxyalkylation treatment by pressing or centrifugal dehydration, the cellulose fiber is heat-treated. The heat treatment may be usually performed using a hot air circulating dryer such as hot air, an electric heater, or an infrared heater. The temperature of the heat treatment is usually 100 ° C. to 200 ° C., and the time of the heat treatment is usually about 15 seconds to 30 minutes. By this heat treatment, cellulose molecules in the cellulose fiber react with halogenoalkanoic acid or the like or further with an alkali metal hydroxide, and the hydrogen atom of the hydroxyl group of the cellulose molecule is substituted with a carboxyalkyl group or an alkali metal carboxyalkyl group.
加熱処理後、セルロース繊維に残存する未反応のハロゲノアルカン酸等、水酸化アルカリ金属及び副反応生成物を除去するために、セルロース繊維を洗浄する。洗浄には、水、アルコール等の有機溶媒、又は水とアルコール等の有機溶媒との混合溶媒が使用できる。また残存する水酸化アルカリ金属を中和するために、酢酸等の酸を混合することが好ましい。 After the heat treatment, the cellulose fibers are washed in order to remove alkali metal hydroxides and side reaction products such as unreacted halogenoalkanoic acid remaining in the cellulose fibers. For washing, an organic solvent such as water and alcohol, or a mixed solvent of water and an organic solvent such as alcohol can be used. In order to neutralize the remaining alkali metal hydroxide, it is preferable to mix an acid such as acetic acid.
上記の方法により得られたアルカリ金属カルボキシアルキル化セルロース繊維を、抗菌性金属化合物の水溶液に浸漬する。これにより、金属イオン置換反応が起こり、アルカリ金属が抗菌性金属イオンに変換される。
抗菌性金属化合物は、水溶性の化合物であればよく、硫酸塩、塩酸塩、酢酸塩、硝酸塩等の塩；水酸化物；等を使用することができる。
水溶性の亜鉛化合物としては、硫酸亜鉛、塩化亜鉛及び酢酸亜鉛を例示することができるが、硫酸亜鉛が好ましい。
The alkali metal carboxyalkylated cellulose fiber obtained by the above method is immersed in an aqueous solution of an antibacterial metal compound. Thereby, a metal ion substitution reaction occurs, and the alkali metal is converted into an antibacterial metal ion.
The antibacterial metal compound may be a water-soluble compound, and salts such as sulfates, hydrochlorides, acetates and nitrates; hydroxides; and the like can be used.
Examples of the water-soluble zinc compound include zinc sulfate, zinc chloride and zinc acetate, but zinc sulfate is preferred.
抗菌性金属化合物による金属イオン置換反応後、反応に関与しないで残存している抗菌性金属化合物を除去するために、セルロース繊維を洗浄する。洗浄には、水、アルコール等の有機溶媒、又は水とアルコール等の有機溶媒との混合溶媒が使用できる。 After the metal ion substitution reaction with the antibacterial metal compound, the cellulose fibers are washed in order to remove the remaining antibacterial metal compound without participating in the reaction. For washing, an organic solvent such as water and alcohol, or a mixed solvent of water and an organic solvent such as alcohol can be used.
本発明の包帯は、セルロース繊維以外の繊維をその構成繊維として含んでいてもよい。セルロース以外の繊維の具体例としては、ポリエステル系繊維、アクリル系繊維、ポリアミド系繊維、アラミド繊維、ポリオレフィン系繊維、ビニロン繊維、ポリウレタン系繊維、ポリ塩化ビニル系繊維、ポリ塩化ビニリデン系繊維等の合成繊維を挙げることができる。 The bandage of the present invention may contain fibers other than cellulose fibers as its constituent fibers. Specific examples of fibers other than cellulose include polyester fibers, acrylic fibers, polyamide fibers, aramid fibers, polyolefin fibers, vinylon fibers, polyurethane fibers, polyvinyl chloride fibers, polyvinylidene chloride fibers, and the like. Mention may be made of fibers.
本発明の包帯は、カルボキシアルキル化セルロース繊維を含んでなることが必須であるが、包帯中にカルボキシアルキル化セルロース繊維を導入する方法は、特に限定されない。
その具体例としては、セルロース繊維を含む包帯を形成した後、その包帯中のセルロース繊維に抗菌性金属カルボキシアルキル基を導入する方法、抗菌性金属カルボキシアルキル化したセルロース繊維を用いて包帯を形成する方法を示すことができる。
Although it is essential that the dressing of the present invention comprises carboxyalkylated cellulose fibers, the method for introducing carboxyalkylated cellulose fibers into the dressing is not particularly limited.
As a specific example, after forming a bandage containing cellulose fibers, a method of introducing an antibacterial metal carboxyalkyl group into the cellulose fibers in the bandage, and forming a bandage using an antibacterial metal carboxyalkylated cellulose fiber A method can be shown.
本発明の包帯の布構造は、織布、編布及び不織布のいずれでもよく、その表面の少なくとも一部に、抗菌性金属カルボキシアルキル化セルロース繊維を有していれば、単層構造でも積層構造でもよい。
織布は、平織、綾織、朱子織等のいずれであってもよい。編布は、経編及び緯編の各種編組織が利用できる。
不織布は、フリース形成法として、乾式法、湿式法及びスパンボンド法のいずれを使用したものであってもよく、繊維結合が、スパンレース法、ニードルパンチ法、ケミカルボンド法、ポイントシール法、サーマルボンド法等のいずれの方法で形成されたものであってもよい。
包帯の布構造を形成する、フィラメント又は糸は特に限定されず、例えば、モノフィラメント、マルチフィラメント、カバードヤーン、コアヤーン、撚糸のいずれでもよく、また、伸縮加工や嵩高加工等の加工をされたものであってもよい。
The fabric structure of the bandage of the present invention may be any of a woven fabric, a knitted fabric and a non-woven fabric, and if it has an antibacterial metal carboxyalkylated cellulose fiber on at least a part of its surface, either a single layer structure or a laminated structure But you can.
The woven fabric may be any of plain weave, twill weave, satin weave and the like. Various knitting structures of warp knitting and weft knitting can be used for the knitted fabric.
The nonwoven fabric may be any one of a dry method, a wet method, and a spunbond method as a fleece forming method, and the fiber bonding is a spunlace method, a needle punch method, a chemical bond method, a point seal method, a thermal method It may be formed by any method such as a bond method.
Filaments or yarns forming the bandage fabric structure are not particularly limited, and may be, for example, monofilaments, multifilaments, covered yarns, core yarns or twisted yarns, and may be subjected to processing such as stretching or bulking. There may be.
包帯の製品形態としては、矩形や円形等の定型の大きさを有するシート状に形成したもの、一定方向に連続した長さを有しロール状に形成したもの、チューブ状に形成したもの等が挙げられる。
特にチューブ状の製品形態は、粘着テープや包帯止め等を用いることなく、清潔さが求められる部分の周囲全面を簡便に被覆することができるので、衛生管理上非常に有利である。
The bandage product form includes a sheet having a standard size such as a rectangle or a circle, a roll having a continuous length in a certain direction, and a tube. Can be mentioned.
In particular, the tube-shaped product form is very advantageous in terms of hygiene management because it can easily cover the entire periphery of a portion requiring cleanliness without using an adhesive tape or bandage stopper.
本発明の包帯の目付け量は、特に限定されないが、１０〜５００ｇ／ｍ２であることが好ましい。
また、本発明の包帯は、好ましくは１０〜５００Ｎ／５０ｍｍ、更に好ましくは２０〜４５０Ｎ／５０ｍｍの湿潤時の引張強度を有する。
このような範囲の湿潤時強度を有することにより、本発明の包帯は、湿潤時に崩壊したり溶解したりせず、実質的に非湿潤時の形体を保持していることができる。
包帯を長期間皮膚に適用した場合には、人体からの多量の分泌液や滲出液と接触することになるが、本発明の包帯は、そのような状況でも実質的に包帯の構造が崩壊することなく、その製品形体を保持し得る程度の強度を有している。これにより、長期間使用した後、患部の処置や包帯の交換のために、包帯を引っ張ったり、引き剥がしたりしても、包帯が千切れたり、患部に繊維の一部が残ったりすることがほとんどなく、容易に患部から取り除くことができる。このような取り扱いの簡便性により、短時間での処置が可能となるので、煩雑な処置にともなう感染のリスクを低減することができる。
The basis weight of the bandage of the present invention is not particularly limited, but is preferably 10 to 500 g / m 2 .
The bandage of the present invention has a wet tensile strength of preferably 10 to 500 N / 50 mm, more preferably 20 to 450 N / 50 mm.
By having the wet strength in such a range, the bandage of the present invention does not disintegrate or dissolve when wet, and can maintain a substantially non-wet form.
When the bandage is applied to the skin for a long period of time, it will come into contact with a large amount of secretion or exudate from the human body, but the bandage of the present invention substantially collapses the structure of the bandage even in such a situation. Without having such strength, the product form can be held. As a result, after using for a long time, even if the bandage is pulled or peeled off for treatment of the affected area or replacement of the bandage, the bandage may be broken or a part of the fiber may remain in the affected area There is little and can be easily removed from the affected area. Such simple handling makes it possible to perform treatment in a short period of time, thereby reducing the risk of infection associated with complicated treatment.
また、本発明の包帯は、好ましくは、１５０〜１，６００％の吸水率を有する。
吸水率がこの範囲内であれば、分泌液や滲出液等の液体を好適に吸収し、また、蒸れや過剰な水分による皮膚への不快感を好適に軽減することができる。
The bandage of the present invention preferably has a water absorption of 150 to 1,600%.
If the water absorption is within this range, liquids such as secretion and exudate can be suitably absorbed, and discomfort to the skin due to stuffiness and excessive moisture can be suitably reduced.
本発明の包帯は、高圧蒸気滅菌後に、Ｌ＊ａ＊ｂ＊表色系によるＬ＊が＋８０〜＋１００、ａ＊が−１０〜＋１０、ｂ＊が−１０〜＋１０であることが好ましい。本発明の包帯は、好ましくは白色である。これにより、体液の滲出や汚れの付着などを容易に認識し易く、また、清潔感がある。
また、本発明の包帯は、高圧蒸気滅菌前後のＬ＊ａ＊ｂ＊表色系による色差（ΔＥ＊ａｂ）が好ましくは１０以下、更に好ましくは５以下である。これにより、高圧蒸気滅菌処理をしても着色の度合いが少ないので、体液の滲出や汚れの付着などを容易に認識し易く、また、清潔感がある。
Dressings of the present invention, after autoclaving, L * a * b * is preferably color system according to L * of + 80 to + 100, a * is the -10 + 10, b * is -10 to + 10. The bandage of the present invention is preferably white. Thereby, exudation of body fluid, adhesion of dirt, etc. can be easily recognized, and there is a feeling of cleanliness.
In the bandage of the present invention, the color difference (ΔE * ab) according to the L * a * b * color system before and after autoclaving is preferably 10 or less, more preferably 5 or less. As a result, since the degree of coloring is small even after the high-pressure steam sterilization treatment, it is easy to recognize exudation of body fluid, adhesion of dirt, and the like, and there is a sense of cleanliness.
また、本発明の包帯は、包帯の縦方向（包帯の製造方向に平行な方向）又は横方向（縦方向に直交する方向）のうち、より伸長する方向において、その伸長率が３０〜５００％であることが好ましい。この範囲の伸長率を有することにより、患部に装着し易く、また、体の動きや皮膚の伸展に対して容易に追従するため、装着時の違和感が軽減される。 Further, the bandage of the present invention has an elongation rate of 30 to 500% in a direction in which the bandage extends in the longitudinal direction (direction parallel to the manufacturing direction of the bandage) or the lateral direction (direction orthogonal to the longitudinal direction). It is preferable that By having an elongation rate in this range, it is easy to be worn on the affected part, and easily follows the movement of the body and the extension of the skin.
本発明の包帯は、長期間使用した場合でも十分な抗菌性を発揮するために、殺菌活性値が０以上であることが好ましく、２以上であることが更に好ましく、４以上であることが特に好ましい。 The bandage of the present invention has a bactericidal activity value of preferably 0 or more, more preferably 2 or more, and particularly preferably 4 or more, in order to exhibit sufficient antibacterial properties even when used for a long time. preferable.
以下に、実施例により本発明を説明する。なお、各例中の部及び％は特に断りのない限り、質量基準である。
また、包帯の各特性の評価方法は、以下のとおりである。
Hereinafter, the present invention will be described by way of examples. In addition, the part and% in each example are mass references | standards unless there is particular notice.
Moreover, the evaluation method of each characteristic of a bandage is as follows.
（アルカリ金属カルボキシルアルキル基置換度）
アルカリ金属カルボキシルメチル基を有するセルロース繊維を含んでなる包帯を、酸を添加した、水とアルコールとの混合溶媒中で処理して、アルカリ金属カルボキシメチル基：−ＣＨ２ＣＯＯＭ（但し、Ｍは、アルカリ金属である。）をカルボキシメチル基：−ＣＨ２ＣＯＯＨに変換する。次に、水とアルコールとの混合溶媒で洗浄後、乾燥し、秤量してその質量（Ｘｇ）を求める。包帯に非セルロース繊維が含まれている場合には、包帯におけるセルロース繊維と非セルロース繊維との比率から、セルロース繊維の質量を算出する。
乾燥後の包帯を容器中に入れ、一定量の水酸化ナトリウム水溶液で溶解する。フェノールフタレイン指示薬を添加した後、過剰の水酸化ナトリウムを規定度Ｎの塩酸で中和滴定して、その使用量をＳｍｌとする。一方、包帯を酸処理しないで同様の操作を行い、塩酸の使用量をＢｍｌとする。
平均置換度は、下記式で求められる。
Ａ＝Ｎ×（Ｂ−Ｓ）／Ｘ
置換度＝０．１６２Ａ／（１−０．０５８Ａ）
(Degree of substitution with alkali metal carboxyl alkyl group)
A bandage comprising cellulose fibers having an alkali metal carboxymethyl group is treated in a mixed solvent of water and alcohol to which an acid is added to obtain an alkali metal carboxymethyl group: —CH 2 COOM (where M is Is converted to a carboxymethyl group: —CH 2 COOH. Next, after washing with a mixed solvent of water and alcohol, it is dried and weighed to determine its mass (Xg). When the non-cellulose fiber is contained in the bandage, the mass of the cellulose fiber is calculated from the ratio of the cellulose fiber and the non-cellulose fiber in the bandage.
The dried bandage is placed in a container and dissolved with a certain amount of aqueous sodium hydroxide solution. After adding the phenolphthalein indicator, the excess sodium hydroxide is neutralized and titrated with normal N hydrochloric acid to make the amount used Sml. On the other hand, the same operation is performed without acid treatment of the dressing, and the amount of hydrochloric acid used is Bml.
The average substitution degree is obtained by the following formula.
A = N × (B−S) / X
Degree of substitution = 0.162A / (1-0.058A)
（消臭率）
１０ｃｍ×１０ｃｍに切断した包帯を５Ｌテドラーバック（東京硝子器械社製）に入れ、１００〜１５０ｐｐｍの濃度に調整したアンモニアガスを３．５Ｌ混入する。検知管を用いて、初期ガス濃度（ｐｐｍ）と、２時間後の残存ガス濃度（ｐｐｍ）を測定し、消臭率を下式により算出する。この値が大きいほど消臭性に優れている。
消臭率（％）＝［（初期ガス濃度−残存ガス濃度）／初期ガス濃度］×１００
(Deodorization rate)
A bandage cut to 10 cm × 10 cm is put into a 5 L tedlar bag (manufactured by Tokyo Glass Instruments Co., Ltd.), and 3.5 L of ammonia gas adjusted to a concentration of 100 to 150 ppm is mixed therein. Using the detector tube, the initial gas concentration (ppm) and the residual gas concentration (ppm) after 2 hours are measured, and the deodorization rate is calculated by the following equation. The larger this value, the better the deodorizing property.
Deodorization rate (%) = [(initial gas concentration−residual gas concentration) / initial gas concentration] × 100
（抗菌性）
ＪＩＳ Ｚ １９０２に記載の方法に準拠し、黄色ブドウ球菌を用いて試験を行う。包帯から、試験片０．４ｇを切り出し、その試験片に菌液０．２ｍｌを滴下し、滴下直後の生菌数（個）、及び３７℃で１８時間放置した後の生菌数（個）を測定し、下式により殺菌活性値を算出する。この値が正で大きいほど殺菌活性が優れている。
殺菌活性値＝標準布（非抗菌布）の試験菌接種直後の生菌数の常用対数値−抗菌加工試料の１８時間培養後の生菌数の常用対数値
(Antibacterial)
In accordance with the method described in JIS Z 1902, a test is performed using Staphylococcus aureus. From the dressing, 0.4 g of a test piece was cut out, 0.2 ml of bacterial solution was dropped onto the test piece, the number of viable bacteria immediately after dropping (number), and the number of viable bacteria after standing at 37 ° C. for 18 hours (number) And the bactericidal activity value is calculated by the following formula. The greater the value, the better the bactericidal activity.
Bactericidal activity value = Common logarithm of the number of viable bacteria immediately after inoculation of test bacteria on standard cloth (non-antibacterial cloth)-Common logarithm of the number of live bacteria after 18 hours of culturing of antibacterial processed samples
（包帯の色及び色差）
高圧蒸気滅菌前と滅菌後の試料のそれぞれについて、自記分光光度計（日本電色工業社製、ＮＦ３３３積分球使用。測定面積８ｍｍφ、測長間隔２０ｍｍ、視野角２°）を用いて、表色法としてＬ＊ａ＊ｂ＊系を用い、Ｌ＊、ａ＊及びｂ＊のそれぞれの値を測定する。また、次の色差式により色差（ΔＥ＊ａｂ）を求める。
ΔＥ＊ａｂ＝〔（ΔＬ＊）２＋（Δａ＊）２＋（Δｂ＊）２〕１／２
ここで、ΔＬ＊は滅菌前と滅菌後の包帯のＬ＊値の差であり、Δａ＊は滅菌前と滅菌後の包帯のａ＊値の差であり、Δｂ＊は滅菌前と滅菌後の包帯のｂ＊値の差である。
また、高圧蒸気滅菌前後の包帯の色を肉眼で確認し、記録する。
(Bandage color and color difference)
For each sample before and after high-pressure steam sterilization, using a self-recording spectrophotometer (manufactured by Nippon Denshoku Industries Co., Ltd., using NF333 integrating sphere, measuring area 8 mmφ, measuring interval 20 mm, viewing angle 2 °) Using the L * a * b * system as a method, the respective values of L * , a * and b * are measured. Further, the color difference (ΔE * ab) is obtained by the following color difference formula.
ΔE * ab = [(ΔL * ) 2 + (Δa * ) 2 + (Δb * ) 2 ] 1/2
Here, ΔL * is the difference between the L * values of the bandage before and after sterilization, Δa * is the difference between the a * values of the bandage before and after sterilization, and Δb * is the difference between before and after sterilization. It is the difference in b * value of the bandage.
Also, visually check the bandage color before and after autoclaving and record.
（吸水率）
５ｃｍ×５ｃｍに裁断した包帯を１０５℃で２時間乾燥し、その乾燥重量を測定した後、生理食塩水（０．９％塩化ナトリウム水溶液）中に浸漬する。３分間浸漬した後、取り出し、１分間吊るし、余分な水を滴下させた後、重量（吸水後重量）を計量し、吸水率を下記式により算出する。
吸水率（％）＝［（吸水後重量−乾燥重量）／乾燥重量］×１００
(Water absorption rate)
The bandage cut to 5 cm × 5 cm is dried at 105 ° C. for 2 hours, measured for its dry weight, and then immersed in physiological saline (0.9% sodium chloride aqueous solution). After being immersed for 3 minutes, taken out, hung for 1 minute, dripped excess water, weighed (weight after water absorption), and calculated the water absorption by the following formula.
Water absorption rate (%) = [(weight after water absorption−dry weight) / dry weight] × 100
（肌触り官能評価）
包帯の表面を手で触り、そのときの感触を、「非常に柔らかい」、「柔らかい」及び「硬い」の３段階で評価する。
(Skin sensory evaluation)
The surface of the bandage is touched by hand, and the feel at that time is evaluated in three levels: “very soft”, “soft” and “hard”.
（伸長率）
包帯から、２００ｍｍ×１００ｍｍの試験片を、縦方向及び横方向のそれぞれから採取する。
試験片の長辺側（２００ｍｍの側）に長辺の固定ジグを取り付け、そのジグに１分間２Ｋｇ荷重を加え包帯を伸長させる。伸長後の、試験片の長さを測定し、下記式により伸長率を求め、縦方向又は横方向の伸長率のうち、より伸張する方を伸長率として記録する。
伸張率（％）＝［（伸張後の試験片の長さ−伸長前の試験片長さ１００ｍｍ）／伸長前の試験片の長さ１００ｍｍ］×１００
(Elongation)
From the bandage, 200 mm × 100 mm specimens are taken from each of the longitudinal and lateral directions.
A fixed jig with a long side is attached to the long side (200 mm side) of the test piece, and a 2 kg load is applied to the jig for 1 minute to extend the bandage. The length of the test piece after stretching is measured, the elongation rate is obtained by the following formula, and the more stretched in the longitudinal direction or the lateral direction is recorded as the stretching rate.
Elongation rate (%) = [(length of test piece after extension−test piece length before extension 100 mm) / length of test piece 100 mm before extension] × 100
（湿潤強度）
包帯から、幅５０ｍｍで、つかみ間隔を２００ｍｍにできる長さ（例えば３００ｍｍ）の試験片を、包帯の縦方向及び横方向につき、各５枚採取する。試験片を生理食塩水（０．９％塩化ナトリウム水溶液）に入れ、試験片が自重で沈下するまで放置するか、又は１０分間生理食塩水中に静止状態で沈めておく。生理食塩水から試験片を取り出し、試験片を、弛みが生じない程度に引っ張った状態で引張試験機（インストロン社製、商品名「ＩＮＳＴＲＯＮ５５６４」、ロードセルに型式２５２５−８０８ １０Ｎ＋を使用）に掴み間隔２００±１ｍｍで取り付け、１００±１０ｍｍの引張速度で、試験片が切断するまで荷重を加える。このときの最大荷重を測定する。縦方向と横方向についてそれぞれ測定し、より高い方を、湿潤時の引張り強度（単位 Ｎ／５０ｍｍ）として記録する。
(Wet strength)
From the bandage, five test pieces each having a width of 50 mm and a length (for example, 300 mm) capable of making the gripping interval 200 mm are taken in the longitudinal and lateral directions of the bandage. Place the test piece in physiological saline (0.9% sodium chloride aqueous solution) and leave it until the test piece sinks under its own weight or let it stand still in physiological saline for 10 minutes. Take out the test piece from the physiological saline, and hold the test piece in a tensile tester (Instron, trade name “INSTRON 5564”, using model 2525-808 10N + for the load cell) in a state where the test piece is pulled to such an extent that no loosening occurs. Install at intervals of 200 ± 1 mm and apply load at a pull rate of 100 ± 10 mm until the specimen is cut. The maximum load at this time is measured. Measure in the longitudinal and transverse directions respectively, and record the higher one as the tensile strength when wet (unit: N / 50 mm).
（実施例１）
綿糸３０／２（３０番手、双糸）を用いて丸編で作製したチューブ状の包帯を、モノクロロ酢酸ナトリウム及び水酸化ナトリウム両試薬を溶解させた水溶液に浸漬した後、適当な脱水率にて包帯を脱水し、その後絶乾状態になるまで乾燥させ、包帯中のセルロース繊維をナトリウムカルボキシメチル化セルロース繊維に変換して、ナトリウムカルボキシメチル化した包帯とした。その後、ナトリウムカルボキシメチル化した包帯を、硫酸亜鉛七水和物、酢酸及び酢酸ナトリウムを溶解させた水溶液に浸漬し、ナトリウムカルボキシメチル化包帯を中和すると同時に、ナトリウムカルボキシメチル化セルロース繊維を亜鉛カルボキシメチル化セルロース繊維へ変換させた。その後、水洗により残存する硫酸亜鉛、酢酸及び酢酸ナトリウムを除去した後、乾燥させ、亜鉛カルボキシメチル化包帯を得た。この包帯について、各特性を評価した。結果を表１に示す。
Example 1
After immersing a tube-shaped bandage made of circular knitting using cotton yarn 30/2 (30 count, double yarn) in an aqueous solution in which both sodium monochloroacetate and sodium hydroxide are dissolved, at an appropriate dehydration rate The bandage was dehydrated and then dried until it was completely dry, and the cellulose fibers in the bandage were converted to sodium carboxymethylated cellulose fibers to obtain sodium carboxymethylated bandages. Thereafter, the sodium carboxymethylated bandage is immersed in an aqueous solution in which zinc sulfate heptahydrate, acetic acid and sodium acetate are dissolved to neutralize the sodium carboxymethylated bandage, and at the same time, the sodium carboxymethylated cellulose fiber is zinc carboxymethylated. Conversion to methylated cellulose fibers. Thereafter, the remaining zinc sulfate, acetic acid and sodium acetate were removed by washing with water, followed by drying to obtain a zinc carboxymethylated dressing. Each characteristic was evaluated about this bandage. The results are shown in Table 1.
（実施例２）
モノクロロ酢酸ナトリウム及び水酸化ナトリウムを変量するほかは実施例１と同様にして、平均置換度を変えた亜鉛カルボキシメチル化包帯を得た。この包帯について、各特性を評価した。結果を表１に示す。
(Example 2)
A zinc carboxymethylated dressing having a different average substitution degree was obtained in the same manner as in Example 1 except that sodium monochloroacetate and sodium hydroxide were changed. Each characteristic was evaluated about this bandage. The results are shown in Table 1.
（実施例３及び４）
包帯の製品形態を銅アンモニアレーヨンからなるシート状の不織布包帯に変更し、また、モノクロロ酢酸ナトリウム及び水酸化ナトリウムを変量したほかは実施例１と同様にして、平均置換度を変えた亜鉛カルボキシメチル化包帯を得た。この包帯について、各特性を評価した。結果を表１に示す。
(Examples 3 and 4)
Zinc carboxymethyl whose average substitution degree was changed in the same manner as in Example 1 except that the dressing product form was changed to a sheet-like non-woven dressing made of copper ammonia rayon, and sodium monochloroacetate and sodium hydroxide were changed. A bandage was obtained. Each characteristic was evaluated about this bandage. The results are shown in Table 1.
（比較例）
実施例１で作製したチューブ状の包帯の未処理品を比較例とした。この包帯について、各特性を評価した。結果を表１に示す。
(Comparative example)
An untreated tube-shaped bandage produced in Example 1 was used as a comparative example. Each characteristic was evaluated about this bandage. The results are shown in Table 1.
表１から分かるように、本発明の包帯は、抗菌性金属カルボキシアルキル基を有していない包帯に比べ非常に高い抗菌性を示す。また、本発明の包帯は、抗菌処理をしても、衛生管理を行う上で重要な、滅菌前後の色、湿潤強度、吸水性、肌触り及び伸長性のような特性においても好適な結果を示す。 As can be seen from Table 1, the bandage of the present invention exhibits a very high antibacterial property compared to a bandage that does not have an antibacterial metal carboxyalkyl group. In addition, the dressing of the present invention shows suitable results in characteristics such as color before and after sterilization, wet strength, water absorption, touch and extensibility, which are important for hygiene management even after antibacterial treatment. .
Claims (7)
高圧蒸気滅菌後のＬ＊ａ＊ｂ＊表色系によるＬ＊が＋８０〜＋１００、ａ＊が−１０〜＋１０、ｂ＊が−１０〜＋１０である包帯。 Carboxyalkylated cellulose fibers having an average degree of substitution of carboxyalkyl groups with zinc carboxyalkyl groups of 0.01 to 0.3 on at least part of the surface;
Pressure after steam sterilization L * a * b * according to the color system L * is + 80 to + 100, a * is -10 to 10, b * is -10 to 10 in which the dressing.
高圧蒸気滅菌前後のＬ＊ａ＊ｂ＊表色系による色差（ΔＥ＊ａｂ）が１０以下である包帯。 Carboxyalkylated cellulose fibers having an average degree of substitution of carboxyalkyl groups with zinc carboxyalkyl groups of 0.01 to 0.3 on at least part of the surface;
A bandage having a color difference (ΔE * ab) of 10 or less according to L * a * b * color system before and after autoclaving.
The bandage according to any one of claims 1 to 6 , which is tube-shaped.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005230356A JP4911398B2 (en) | 2005-08-09 | 2005-08-09 | bandage |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005230356A JP4911398B2 (en) | 2005-08-09 | 2005-08-09 | bandage |
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| Publication Number | Publication Date |
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| JP4911398B2 true JP4911398B2 (en) | 2012-04-04 |
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| JP6727550B2 (en) * | 2016-09-30 | 2020-07-22 | 日本製紙株式会社 | Twisted yarn |
| KR102493617B1 (en) * | 2018-03-13 | 2023-01-30 | 주식회사 엘지화학 | Method for manufacturing non-woven fabric for adsorbing heavy metal and non-woven fabric for adsorbing heavy metal manufactured thereby |
| CN112245645A (en) * | 2020-09-01 | 2021-01-22 | 世纪亿康（天津）医疗科技发展有限公司 | Hemostatic and antibacterial medical dressing and preparation method thereof |
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| JP2557645B2 (en) * | 1987-04-30 | 1996-11-27 | 株式会社 興人 | Deodorant fiber |
| JPH03242145A (en) * | 1990-02-19 | 1991-10-29 | Terumo Corp | Wound covering material and production thereof |
| JPH0967750A (en) * | 1995-08-28 | 1997-03-11 | Oji Paper Co Ltd | Antimicrobial water absorbing sheet |
| JP4101628B2 (en) * | 2002-12-10 | 2008-06-18 | 東海染工株式会社 | Method for producing dyed deodorant cellulosic fabrics |
| US7629000B2 (en) * | 2003-05-13 | 2009-12-08 | E.I. Du Pont De Nemours And Company | Method for making antimicrobial polyester-containing articles with improved wash durability and articles made thereby |
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