JP4769153B2 - Cosmetics - Google Patents
Cosmetics Download PDFInfo
- Publication number
- JP4769153B2 JP4769153B2 JP2006246264A JP2006246264A JP4769153B2 JP 4769153 B2 JP4769153 B2 JP 4769153B2 JP 2006246264 A JP2006246264 A JP 2006246264A JP 2006246264 A JP2006246264 A JP 2006246264A JP 4769153 B2 JP4769153 B2 JP 4769153B2
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- JP
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- Prior art keywords
- extract
- juice
- eggplant
- acid
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Landscapes
- Cosmetics (AREA)
Description
本発明は、皮膚の老化防止や肌荒れの予防・改善に有効な化粧料に関し、詳しくは、表皮細胞におけるコラーゲン産生促進作用と真皮線維芽細胞におけるコラーゲン産生促進作用を併せ持ち、それら両作用の相乗的効果により皮膚の老化防止や肌荒れの予防・改善に高い有効性を示すと共に生体安全性にもすぐれた天然物由来成分を含んでなり、皮膚を健常で且つ若々しい状態に保持し或いは改善するために用いて有用な化粧料に関する。 The present invention relates to a cosmetic that is effective for preventing skin aging and preventing or improving rough skin. More specifically, the present invention has both a collagen production promoting action in epidermal cells and a collagen production promoting action in dermal fibroblasts, and the synergistic effect of these two actions. Contains natural ingredients that are highly effective in preventing skin aging and preventing and improving rough skin, and is effective in maintaining or improving the skin in a healthy and youthful state. It is related with the cosmetics useful for use.
皮膚の老化は、加齢に伴う細胞増殖・分化の不活化やホルモン分泌の低下などの内的要因と、太陽光(紫外線)に誘発される活性酸素による細胞・組織の損傷、細胞外マトリックス成分の量的低下或いは炎症などの外的要因が複雑に絡み合って生ずる現象である。それらの内、内的要因に基づく皮膚の老化は、表皮細胞の活性低下、特にIV型およびVII型コラーゲン、ラミニンなどの基底膜を構成するタンパク質の合成低下に基づく表皮基底細胞の不活化により、皮膚角質層のバリア機能、皮脂分泌機能、水分保持機能が低下することによって生じる。また、真皮線維芽細胞の活性低下や増殖能の低下、或いはコラーゲン、エラスチン、ヒアルロン酸などの真皮マトリックス成分が減少し、皮膚組織が柔軟性や弾力を失うことも皮膚老化の原因となり、皮膚の形態的・生理的変化としては、シワ、タルミ、肌荒れなどの症状として現れる。
この皮膚の老化を防ぎ、皮膚を健全且つ若々しい状態に保持するため、従来より種々の活性成分の使用が提案され、それら成分を配合した化粧品が上市されている。例えば、ビタミンC類、ビタミンE類などの抗酸化剤、グリチルリチン酸などの抗炎症剤、各種紫外線吸収剤、α-ヒドロキシカルボン酸、胎盤抽出液、γ-アミノ-β-ヒドロキシ酪酸などの細胞賦活成分、コラーゲン、エラスチン、ヒアルロン酸などの細胞外マトリックス成分、尿素などの保湿剤等がそれである。
しかしながら、それら成分は一般に、上述した皮膚老化要因のうちの一部を防止或いは改善することに与るに過ぎないため、それら成分を配合した従来の化粧料によっては、真に満足し得る皮膚老化防止効果は得られないのが現状である。また、成分の種類によっては、皮膚刺激性や皮膚感作性を有するなど生体に対する安全性に問題があったり、或いは細胞の活性化、増殖作用が十分ではないなどの難点もある。
Skin aging is caused by internal factors such as inactivation of cell growth / differentiation associated with aging and a decrease in hormone secretion, cell / tissue damage by active oxygen induced by sunlight (ultraviolet rays), and extracellular matrix components. This is a phenomenon that is caused by complicated intertwining of external factors such as quantitative decrease in inflammation or inflammation. Among them, aging of the skin based on internal factors is due to inactivation of epidermal basal cells based on decreased activity of epidermal cells, particularly decreased synthesis of proteins constituting basement membranes such as type IV and type VII collagen and laminin, This is caused by a decrease in the barrier function, sebum secretion function, and water retention function of the skin stratum corneum. In addition, dermal fibroblast activity declines and proliferative ability, or dermal matrix components such as collagen, elastin, and hyaluronic acid decrease, and skin tissue loses flexibility and elasticity, which also causes skin aging. As morphological and physiological changes, symptoms such as wrinkles, tarmi and rough skin appear.
In order to prevent this skin aging and keep the skin healthy and youthful, the use of various active ingredients has been proposed and cosmetics containing these ingredients have been put on the market. For example, antioxidants such as vitamin C and vitamin E, anti-inflammatory agents such as glycyrrhizic acid, various ultraviolet absorbers, α-hydroxycarboxylic acid, placental extract, and cell activation such as γ-amino-β-hydroxybutyric acid Ingredients, extracellular matrix components such as collagen, elastin and hyaluronic acid, humectants such as urea, and the like.
However, since these ingredients generally only serve to prevent or improve some of the above-mentioned skin aging factors, depending on the conventional cosmetics containing these ingredients, the skin aging that is truly satisfactory At present, the prevention effect cannot be obtained. In addition, depending on the type of component, there are problems such as having skin irritation and skin sensitization, and there are problems with safety against living bodies, or cell activation and proliferation are not sufficient.
本発明者らは、従来の化粧料にみられる上述のごとき問題点に鑑み、皮膚の老化、肌荒れ等の諸要因に対して複合的、多面的に作用することにより皮膚の老化防止や肌荒れの予防・改善に高い有効性を示すと共に、皮膚に対する安全性の点でも十分満足し得る新たな化粧料配合成分を見出すべく鋭意研究を行った結果、水ナスの搾汁液、さらにはそのエキスが、表皮細胞のコラーゲン産生の促進作用と真皮線維芽細胞のコラーゲン産生を促進する作用を併せ持つと共に、古くから食している野菜に由来するものであることから生体安全性にもすぐれ、上記の目的に合致するものであることを知り、本発明を完成するに至った。 In view of the above-mentioned problems seen in conventional cosmetics, the present inventors have combined and multifaceted action against various factors such as skin aging and rough skin, thereby preventing skin aging and rough skin. As a result of diligent research to find a new cosmetic compounding ingredient that shows high effectiveness in prevention and improvement, and is also sufficiently satisfactory in terms of safety to the skin, squeezed juice of water eggplant, and its extract, In addition to promoting the collagen production of epidermal cells and promoting collagen production of dermal fibroblasts, it is derived from vegetables that have been eaten for a long time, so it has excellent biological safety and meets the above objectives. As a result, the present invention has been completed.
ナス科ナス属(ソラナム属;Solanum)の植物の成分を化粧料配合原料として利用することについては、従来より種々の提案がなされている。
例えば、特開平03−190809号公報には、ナスの抽出物を含む皮膚外用剤が肌荒れ防止・改善効果、特に活性剤による炎症及び過剰なターンオーバーの亢進を抑制することに基づく肌荒れ防止・改善効果を有することが、特開平10−316530号公報には、ナス科ソラナム属の植物の抽出物がメラニンの生成を抑制し、日焼け後の色素沈着、しみ、そばかす、肝斑等の予防及び改善に有効であることが、特開2000−290162号公報には、ナスなどの野菜の野菜汁を濃縮する工程で分離される野菜由来の水を配合した化粧料によって、皮膚にしっとり感、潤い感などの使用感および保湿効果、柔軟効果が付与されることが、特開2001−131046号公報には、ナス科植物のエッセンスからなる過酸化水素消去剤及びこれを含む皮膚外用剤が、特開2001−139420号公報には、ナスのエッセンスにカタラーゼを活性化する効果があり、過酸化水素の消去に用いて有効であることが、又特開2001−226219号公報には、ナスの水蒸気蒸留水を含有する化粧料組成物が乾燥肌を改善し、肌にツヤ・張りを与える効果を有することが、それぞれ開示されている。
Various proposals have heretofore been made for using plant components of the solanaceous genus (Solanum genus) as cosmetic ingredients.
For example, Japanese Patent Laid-Open No. 03-190809 discloses a skin external preparation containing an extract of eggplant that prevents or improves rough skin, and in particular, prevents or improves rough skin based on suppressing inflammation and excessive turnover by an active agent. JP-A-10-316530 discloses that an extract of a plant belonging to the genus Solanum belongs to the genus Solanum, which suppresses the production of melanin, and prevents and improves pigmentation, blotches, freckles, and liver spots after sunburn. JP 2000-290162 discloses that the skin is moist and moisturized by a cosmetic containing water derived from vegetables separated in the step of concentrating vegetable juice of vegetables such as eggplant. Japanese Patent Application Laid-Open No. 2001-131046 discloses a hydrogen peroxide scavenger composed of the essence of solanaceous plants and this. JP-A-2001-139420 has an effect of activating catalase in the essence of eggplant and is effective for use in eliminating hydrogen peroxide. JP-A-2001-226219 The publication discloses that a cosmetic composition containing eggplant steam distilled water has the effect of improving dry skin and imparting gloss and tension to the skin.
しかしながらそれら公知文献には、ナス科ナス属(ソラナム属;Solanum)の植物として本発明に云う水ナス(Solanum Melongena;Egg plant c.v.‘Mizu−nasu’)を使用することを具体的に開示したものは全く見当たらない。
又、後に試験例1及び2に示す通り、ナス類の搾汁液或いはエキスが有する表皮細胞のコラーゲン産生促進効果や真皮線維芽細胞のコラーゲン産生促進効果は、ナス(Solanum Melongena)の中でも特に水ナス(Solanum Melongena;Egg plant cv.Mizunasu)に顕著に認められるが、かかる事実に関しても、当然ながら公知文献中には何ら記載もなされておらず又これを示唆するものすら示されていない。
唯、それら公知文献のうちには、例えば特開2001−139420号公報や同2001−226219号公報にみられるように、ナス由来の成分に、過酸化水素消去に基づくシワ防止効果や乾燥肌の改善によるツヤ・張りの付与効果などの皮膚老化防止効果があることを開示したものがあるが、後述のモニターテストの結果に示す通り、それら公知文献の発明で用いる一般汎用のナスの成分が奏する肌のシワや張りの改善などの抗老化効果は、本発明の水ナス由来の成分のそれに遙かに及ばないものである。本発明の水ナスによってかかる特段の効果が奏し得られる理由については、前述の通りナス類のうちでも特に水ナスに、表皮細胞と真皮線維芽細胞の両細胞のコラーゲン産生を促進するという複合的、多面的な抗老化作用のあることが大きく寄与しているものと推察される。
いずれにせよ上述の公知文献の記載からは、本発明で有効成分として用いる水ナスの搾汁液やそのエキスが、表皮細胞のコラーゲン産生と真皮線維芽細胞のコラーゲン産生を顕著に促進する効果を併せ持ち、それら両作用の相乗効果によって表皮、基底膜さらには真皮を健全、健常化することを通じて、一般に汎用されているナスに由来する成分に比べて遙かにすぐれた皮膚老化防止効果、肌荒れの予防、改善効果を奏することについては、これを到底予測し得ないことが明らかである。
However, in these known documents, the use of water eggplant (Solanum Melongena; Egg plant cv. 'Mizu-nasu') according to the present invention as a plant of the genus Solanum (Solanum) is specifically described. There is no disclosure at all.
Further, as shown in Test Examples 1 and 2 later, the collagen production promoting effect of epidermis cells and the collagen production promoting effect of dermal fibroblasts possessed by eggplant squeezed juice or extract are especially water eggplants among eggplants (Solanum Melongena). (Solanum Melongena; Egg plant cv. Mizunasu), it is obvious that there is no description in the publicly known literature or suggesting this fact.
However, among those known documents, for example, as seen in Japanese Patent Application Laid-Open Nos. 2001-139420 and 2001-226219, the eggplant-derived component has a wrinkle-preventing effect based on hydrogen peroxide erasure and dry skin. There are those disclosed that there is an effect of preventing skin aging such as the effect of imparting gloss and tension by improvement, but as shown in the results of the monitor test described later, the general-purpose eggplant component used in the inventions of those known documents has an effect The anti-aging effect such as improvement of skin wrinkles and tension is far less than that of the component derived from water eggplant of the present invention. The reason why such a special effect can be obtained by the water eggplant according to the present invention is that, as described above, among the eggplants, the water eggplant particularly promotes the collagen production of both epidermal cells and dermal fibroblasts. It is speculated that the multifaceted anti-aging effect contributes greatly.
In any case, from the description of the above-mentioned publicly known literature, the squeezed juice of water eggplant and its extract used as an active ingredient in the present invention have the effect of remarkably accelerating collagen production of epidermal cells and collagen production of dermal fibroblasts. Through the synergistic effect of these two actions, the skin, basement membrane, and even the dermis are made healthy and healthy, which is far superior to the commonly used eggplant-derived ingredients, preventing skin aging and preventing rough skin. It is clear that it is impossible to predict the improvement effect.
即ち本発明は、水ナスの搾汁液及び/又はエキスから選ばれた1種又は2種以上を配合したことを特徴とする老化防止化粧料に関するものである。
又本発明は、水ナスの搾汁液及び/又はエキスから選ばれた1種又は2種以上を有効成分として含む表皮細胞及び真皮線維芽細胞のコラーゲン産生促進剤に関するものでもある。
ここで水ナスとは、ナスの品種のうち在来系統7品種、水茄子柔、和泉水茄子、泉州絹川水茄子などの品種を指し(大阪農技セ研報
35:34〜39(1999))、特にそれら品種を大阪の泉州地域で栽培したものが本発明に於いて好適に用いられる。
本発明に於いてエキスとは、水ナスの乾燥粉砕物、抽出液或いは抽出液から濃縮などにより溶媒を除いて得られる固形成分を意味する。
又、本発明に於いて化粧料なる文言は、所謂化粧料のほかに医薬部外品をも含む広義で用いる。
That is, this invention relates to the anti-aging cosmetic characterized by mix | blending the 1 type (s) or 2 or more types chosen from the squeezed juice and / or extract of water eggplant.
The present invention also relates to an agent for promoting collagen production of epidermal cells and dermal fibroblasts, which contains one or more selected from squeezed juice and / or extract of water eggplant as an active ingredient.
As used herein, “water eggplant” refers to varieties such as seven conventional varieties of eggplant varieties, such as coconut coconut jelly, Izumi coconut lion, and Quanzhou kinkawa mizuko (Osaka Agricultural Science Research Report 35: 34-39 (1999)). In particular, those cultivated in the Quanzhou area of Osaka are preferably used in the present invention.
In the present invention, the extract means a dry pulverized product of water eggplant, an extract or a solid component obtained by removing the solvent from the extract by concentration or the like.
In the present invention, the term cosmetic is used in a broad sense including so-called cosmetics and quasi-drugs.
水ナスの搾汁液及び/又はエキスは表皮細胞と真皮線維芽細胞の両細胞のコラーゲン産生促進効果を併せ持っており、それら作用の複合に基づく相乗的な抗老化作用により、本発明の化粧料は、皮膚の弾力性やハリを向上させて、シワやタルミなどの皮膚の老化や不健全化の症状を予防或いは改善し、皮膚を真に健全で若々しい状態に維持する。
又、本発明化粧料で活性成分として用いる水ナスの搾汁液或いはエキスは、皮膚に対する刺激性がなく、このため本発明の化粧料は生体安全性にも大変すぐれている。
Juice eggplant squeezed juice and / or extract have both collagen production promoting effects of both epidermal cells and dermal fibroblasts, and the cosmetic composition of the present invention has a synergistic anti-aging action based on a combination of these actions. It improves skin elasticity and firmness, prevents or ameliorates skin aging and unhealthy symptoms such as wrinkles and tarmi, and keeps the skin truly healthy and youthful.
Also, the squeezed juice or extract of water eggplant used as an active ingredient in the cosmetic composition of the present invention has no irritation to the skin, and therefore the cosmetic composition of the present invention is very excellent in biological safety.
以下、本発明について詳細に説明する。
本発明に於いて、水ナスとしては、在来系統7品種、水茄子柔、和泉水茄子、泉州絹川水茄子などを用いることができる。
Hereinafter, the present invention will be described in detail.
In the present invention, as the eggplant, seven types of conventional strains such as cocoon syrup, suizu mizuko, zumishu kinkawa coconut, and the like can be used.
本発明の化粧料には、上記の水ナスの搾汁液(果汁)及び/又はエキスの1種又は2種以上が有効成分として配合される。
水ナスの搾汁液及びエキスは、後に試験例に示す通り、表皮細胞及び真皮線維芽細胞の両細胞に対して、それらのコラーゲン産生を顕著に促進する作用を有しており、表皮細胞及び真皮線維芽細胞のコラーゲン産生促進剤として用いることができる。
In the cosmetic composition of the present invention, one or more of the above-described squeezed juice (fruit juice) and / or extract of the water eggplant is blended as an active ingredient.
As shown later in the test examples, the squeezed juice and extract of water eggplant have an action of remarkably accelerating their collagen production on both epidermal cells and dermal fibroblasts. It can be used as a collagen production promoter for fibroblasts.
水ナスの搾汁液は果実をそのまま圧搾するか、もしくは果実を破砕したのち、その破砕物を圧搾することにより調製することができる。
又水ナスのエキスは、水ナスの果実を乾燥したのち粉砕して乾燥粉砕物とするか、もしくは水ナスの搾汁液汁或いは果実、又場合によっては搾汁液に凍結乾燥等を施して得られる乾燥粉末を溶媒で抽出することによって調製される。
水ナスの果実からの抽出エキスの調製は、果実を、必要に応じてこれに予め水洗、乾燥処理などを施した上、浸漬法、向流抽出法など適宜の手段により抽出溶媒と接触させることによって行うことができる。又、超臨界抽出法を用いてもよい。
The squeezed juice of water eggplant can be prepared by pressing the fruit as it is or by crushing the fruit and then pressing the crushed material.
The extract of water eggplant is obtained by drying and pulverizing the fruit of water eggplant to obtain a dried pulverized product, or by lyophilizing the juice or fruit of the water eggplant or, in some cases, the juice. Prepared by extracting dry powder with solvent.
Preparation of extract from water eggplant fruit is made by bringing the fruit into contact with an extraction solvent by appropriate means such as dipping method or countercurrent extraction method after pre-washing it with water, drying treatment etc. if necessary. Can be done by. A supercritical extraction method may also be used.
抽出溶媒としては、水;メタノール、エタノール、プロパノールなどの低級アルコール類、オレイルアルコール、ステアリルアルコール、オクチルドデカノールなどの高級アルコール類;エチレングリコール、プロピレングリコール、1,3−ブチレングリコール、グリセリンなどの多価アルコール類;酢酸エチル、酢酸ブチル、プロピオン酸メチル、トリオクタン酸グリセリルなどのエステル類;アセトン、メチルエチルケトンなどのケトン類;エチルエーテル、イソプロピルエーテルなどのエーテル類;n−ヘキサン、トルエン、クロロホルムなどの炭化水素系溶媒などが挙げられ、それらは単独でもしくは二種以上混合して用いられる。
なお、得られる抽出エキスの表皮細胞及び真皮線維芽細胞に於けるコラーゲン産生促進作用の観点から、本発明に於いては、それら溶媒のうちでも特には高極性のものが好適に使用される。さらには化粧料への幅広い適用が可能であるという点からも、水、低級アルコール類及び多価アルコール類から選ばれた一種の単独溶媒又は二種以上の混合溶媒の使用が好ましく、なかでも水の単独使用が最も好ましい。
As an extraction solvent, water; lower alcohols such as methanol, ethanol, and propanol; higher alcohols such as oleyl alcohol, stearyl alcohol, and octyldodecanol; many solvents such as ethylene glycol, propylene glycol, 1,3-butylene glycol, and glycerin Monohydric alcohols; esters such as ethyl acetate, butyl acetate, methyl propionate and glyceryl trioctanoate; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; carbonization such as n-hexane, toluene and chloroform Examples thereof include hydrogen-based solvents, which are used alone or in combination of two or more.
From the viewpoint of promoting collagen production in the epidermal cells and dermal fibroblasts of the extracted extract, in the present invention, among these solvents, those having high polarity are particularly preferably used. Furthermore, it is preferable to use one kind of single solvent or two or more kinds of mixed solvents selected from water, lower alcohols and polyhydric alcohols from the viewpoint that they can be widely applied to cosmetics. Is most preferably used alone.
混合溶媒を用いる場合の混合比は、例えば水とエチルアルコールとの混合溶媒であれば、容量比(以下同じ)で1:1〜25:1、水とグリセリンとの混合溶媒であれば1:1〜20:1、又水と1,3−ブチレングリコールとの混合溶媒であれば、1:1〜20:1の範囲とすることが好ましい。 The mixing ratio in the case of using a mixed solvent is, for example, 1: 1 to 25: 1 by volume ratio (hereinafter the same) if the mixed solvent is water and ethyl alcohol, and 1: if the mixed solvent is water and glycerin. In the case of a mixed solvent of 1 to 20: 1, or water and 1,3-butylene glycol, it is preferably in the range of 1: 1 to 20: 1.
本発明の抽出エキスの調製に際して、抽出液のpHは5〜9の範囲に保持されることが好ましく、かかる意味で、必要ならば上記の抽出溶媒に、水酸化ナトリウム、炭酸ナトリウム、水酸化カリウム、アルギニンなどのアルカリ性調整剤や、クエン酸、塩酸、リン酸、硫酸などの酸性調整剤等を配合し、所望のpHとなるように調整してもよい。 In the preparation of the extract of the present invention, the pH of the extract is preferably maintained in the range of 5 to 9. In this sense, if necessary, the above extraction solvent may contain sodium hydroxide, sodium carbonate, potassium hydroxide. Alternatively, an alkaline adjusting agent such as arginine, an acidic adjusting agent such as citric acid, hydrochloric acid, phosphoric acid, sulfuric acid, or the like may be blended to adjust to a desired pH.
抽出温度、時間等の抽出条件は、用いる溶媒の種類等によっても異なるが、例えば浸漬法の場合であれば、抽出温度は、一般に15〜100℃、好ましくは60〜90℃の範囲であり、又抽出時間は、0.1〜24時間程度、特に0.5〜3時間程度が好適である。 Although extraction conditions such as extraction temperature and time vary depending on the type of solvent used, for example, in the case of the immersion method, the extraction temperature is generally in the range of 15 to 100 ° C., preferably 60 to 90 ° C., The extraction time is preferably about 0.1 to 24 hours, particularly about 0.5 to 3 hours.
以上の抽出処理が終わったならば、ろ過、遠心分離などの固液分離手段を施して液相を分取し、一般にはそのpHを化粧料配合成分として好ましい範囲である4〜8に調整した上、これをそのまま、もしくは希釈或いは減圧濃縮等により適宜の濃度に調整して化粧料に配合する。又必要ならば、この液相をスプレードライ法、凍結乾燥法など常法に従って粉末化して化粧料に配合してもよく、さらに場合によっては、固液分離手段を施す前の抽出原液を化粧料に配合することもできる。
又上記の粉末化処理は、水ナスの搾汁液にこれを施してもよい。
When the above extraction process is completed, the liquid phase is separated by applying solid-liquid separation means such as filtration and centrifugation, and the pH is generally adjusted to 4 to 8 which is a preferable range as a cosmetic ingredient. In addition, it is blended in cosmetics as it is or after adjusting to an appropriate concentration by dilution or vacuum concentration. If necessary, this liquid phase may be powdered according to conventional methods such as spray-drying and freeze-drying and blended into cosmetics. In some cases, the extraction stock solution before applying solid-liquid separation means may be used as a cosmetic. It can also be blended.
Moreover, you may give this to the squeezed juice of water eggplant in said powdering process.
なお、本発明の水ナスの搾汁液或いはエキスの表皮細胞及び真皮線維芽細胞に於けるコラーゲン産生促進作用は、水ナスの果実、搾汁液或いはエキスに加水分解処理を施してもそのまま保持されるだけでなく、加水分解処理を行った場合、抽出時の操作性や得られた抽出液の保存安定性が向上するという利点もあることから、必要に応じて加水分解処理を行ってもよい。加水分解処理の条件としては、酸加水分解、アルカリ加水分解、酵素加水分解などの常法を用いることができる。 It should be noted that the collagen production promoting action in the epidermis cells and dermal fibroblasts of the squeezed juice or extract of the water eggplant of the present invention is maintained as it is even if the fruit, juice or extract of mizusaki is subjected to a hydrolysis treatment. In addition, when the hydrolysis treatment is performed, there is an advantage that the operability at the time of extraction and the storage stability of the obtained extract are improved. Therefore, the hydrolysis treatment may be performed as necessary. As conditions for the hydrolysis treatment, conventional methods such as acid hydrolysis, alkali hydrolysis, enzyme hydrolysis and the like can be used.
水ナスの果実、搾汁液或いはエキスに酵素加水分解処理を施す場合、酵素としては、アクチナーゼ、パパインなどの蛋白分解酵素、グルコアミラーゼ、α-アミラーゼなどの澱粉分解酵素、セルラーゼ、ヘミセルラーゼ、ペクチナーゼなどの繊維素分解酵素及びリパーゼなどの脂肪分解酵素から選ばれた1種又は2種以上が用いられ、特にそれら4種の酵素群からそれぞれ選ばれた1種又は2種以上の酵素を組み合わせ用いることが好ましい。 When enzyme hydrolysis is applied to the fruit, juice or extract of water eggplant, the enzymes include proteolytic enzymes such as actinase and papain, starch-degrading enzymes such as glucoamylase and α-amylase, cellulase, hemicellulase, pectinase, etc. 1 type or 2 or more types selected from lipolytic enzymes such as fibrinolytic enzymes and lipases are used, and in particular, 1 type or 2 or more types of enzymes selected from these 4 types of enzymes are used in combination. Is preferred.
それらの酵素による水ナス(果実)、その搾汁液或いはエキスの加水分解処理は、果実或いはエキス粉末を用いる場合であれば、果実は好ましくは予め破砕して細片化した上、それらを水或いは水と低級アルコールもしくは多価アルコールとの混液、好適には水に懸濁或いは溶解した後 、又果汁或いはエキス溶液を用いる場合であれば、それら溶液をそのまま、もしく必要に応じて濃度調整等を施した後、これに酵素を添加し、酵素の至適温度付近に1〜24時間保持することによって行われる。
この場合、エキス溶液の溶媒組成が、酵素反応の妨げとなる恐れのあるときには、該溶媒を一旦留去した上、ここに得られるエキス粉末を好ましくは水に再溶解或いは分散させて酵素処理を行うようにする。
酵素の添加量は、被処理物として果実を用いる場合であれば、その固形分に対して、合計で0.01〜10重量%、好ましくは0.1〜1.0%の範囲であり、又搾汁液、エキス溶液又はエキス粉末を用いる場合は、同じく固形分に対して合計で0.001〜5重量、好ましくは0.01〜0.5重量%の範囲である。
In the case of using fruit or extract powder, the hydrolyzing treatment of water eggplant (fruit), juice or extract with those enzymes is preferably pre-crushed and fragmented, and then water or If a mixed solution of water and lower alcohol or polyhydric alcohol, preferably suspended or dissolved in water, and then using fruit juice or extract solution, adjust the concentration of the solution as it is or as necessary. After the treatment, the enzyme is added thereto, and the mixture is kept at around the optimum temperature of the enzyme for 1 to 24 hours.
In this case, when the solvent composition of the extract solution may hinder the enzyme reaction, the solvent is once distilled off, and the extract powder obtained here is preferably re-dissolved or dispersed in water to carry out the enzyme treatment. To do.
The amount of enzyme added is 0.01 to 10% by weight, preferably 0.1 to 1.0% in total, based on the solid content, when fruits are used as the object to be treated. Moreover, when using a squeezed liquid, an extract solution, or extract powder, it is 0.001-5 weight in total with respect to solid content similarly, Preferably it is the range of 0.01-0.5 weight%.
以上の酵素加水分解処理が終わったならば、処理液に加熱処理を施して酵素を失活させた後、ここに得られる液をそのまま、もしくはろ過、遠心分離などによって液相を分取し、さらに必要ならばpH調整、濃度調整或いは粉末化処理等を施した上、化粧料の配合原料として供する。 When the above enzymatic hydrolysis treatment is completed, the treatment liquid is subjected to a heat treatment to deactivate the enzyme, and the liquid obtained here is collected as it is or by filtration, centrifugation, etc. Further, if necessary, it is subjected to pH adjustment, concentration adjustment, powdering treatment, etc. and then used as a cosmetic raw material.
以上の如くして調製される本発明の水ナス(Solanum Melongena;Egg plant c.v.Mizu−nasu)の搾汁液或いはそのエキスは、後に試験例に示す通り、表皮細胞及び真皮線維芽細胞のコラーゲン産生を顕著に促進する効果を有し、しかも皮膚に対する刺激性が少ないなど生体安全性にすぐれ、化粧料への配合剤として有用なものである。 The squeezed juice of the eggplant (Solanum Melongena; Egg plant cv Mizu-nasu) of the present invention prepared as described above or an extract thereof, as shown in the test examples later, is used for epidermal cells and dermal fibroblasts. It has an effect of remarkably promoting collagen production, and is excellent in biological safety, such as being less irritating to the skin, and is useful as a formulation for cosmetics.
本発明の水ナスの搾汁液及び/又はエキス或いはそれらの酵素加水分解処理物を配合してなる化粧料としては、例えば乳液、クリーム、ローション、エッセンス、パック、洗顔料などの基礎化粧料、口紅、ファンデーション、リキッドファンデーション、メイクアッププレスパウダーなどのメイクアップ化粧料、ヘアーシャンプー、ヘアーリンス、ヘアートリートメント、コンディショナー、染毛料、整髪料などの頭髪化粧料、洗顔料、ボディーシャンプー、石けんなどの清浄用化粧料、さらには浴剤等が挙げられるが、勿論これらに限定されるものではない。 Examples of cosmetics obtained by blending the squeezed juice and / or extract of the present invention or their hydrolyzed products thereof include, for example, basic cosmetics such as emulsions, creams, lotions, essences, packs, facial cleansers, and lipsticks. Makeup cosmetics such as foundations, liquid foundations, makeup press powders, hair shampoos, hair rinses, hair treatments, conditioners, hair dyes, hair conditioners and other hair cosmetics, facial cleansers, body shampoos, soaps, etc. Although cosmetics, a bath agent, etc. are mentioned, of course, it is not limited to these.
本発明の化粧料中に於ける水ナスの搾汁液及び/又はエキス或いはそれらの酵素加水分解処理物の配合量は、固形分として、例えば基礎化粧料については、一般に0.001〜5重量%、好ましくは0.01〜3重量%の範囲、メイクアップ化粧料ついては、一般に0.001〜5重量%、好ましくは0.01〜2重量%の範囲、頭髪化粧料については、一般に0.001〜10重量%、好ましくは0.01〜5重量%の範囲、又清浄用化粧料については、一般に0.001〜10重量%、好ましくは0.01〜5重量%の範囲である。 The blended amount of the squeezed squeezed liquid and / or extract or enzyme hydrolyzed product thereof in the cosmetic of the present invention is generally 0.001 to 5% by weight as a solid content, for example, for basic cosmetics. , Preferably in the range of 0.01 to 3% by weight, for makeup cosmetics in general 0.001 to 5% by weight, preferably in the range of 0.01 to 2% by weight, and for hair cosmetics in general 0.001. It is generally in the range of 0.001 to 10% by weight, preferably in the range of 0.01 to 5% by weight.
本発明の化粧料には、必須成分の水ナスの搾汁液及び/又はエキスのほかに、通常化粧料に用いられる成分、例えば油性成分、界面活性剤、保湿剤、増粘剤、防腐・殺菌剤、粉体成分、紫外線吸収剤、生理活性成分(美白成分、老化防止・美肌化・シワ防止成分など)、抗炎症剤、抗酸化剤、色素、香料等を必要に応じて適宜配合することができる。
又、本発明の水ナスの搾汁液及び/又はそのエキスの有効性や特長を損なわない限り、既知のコラーゲン合成促進剤を併せ配合することもできる。
The cosmetics of the present invention include components that are usually used in cosmetics, such as oily ingredients, surfactants, moisturizers, thickeners, antiseptics / sterilizers, in addition to the squeezed juice and / or extract of essential eggplant water. Add appropriate ingredients such as powders, powder components, UV absorbers, physiologically active ingredients (whitening ingredients, anti-aging / skin-care / wrinkle-preventing ingredients, etc.), anti-inflammatory agents, antioxidants, pigments, fragrances, etc. Can do.
In addition, a known collagen synthesis promoter can also be blended as long as the effectiveness and features of the squeezed squeezed juice and / or extract thereof of the present invention are not impaired.
ここで、油性成分としては、例えばオリーブ油、ホホバ油、ヒマシ油、大豆油、米油、米胚芽油、ヤシ油、パーム油、カカオ油、メドウフォーム油、シアーバター、ティーツリー油、アボガド油、マカデミアナッツ油、植物由来スクワランなどの植物由来の油脂類;ミンク油、タートル油などの動物由来の油脂類;ミツロウ、カルナウバロウ、ライスワックス、ラノリンなどのロウ類;流動パラフィン、ワセリン、パラフィンワックス、スクワランなどの炭化水素類;ミリスチン酸、パルミチン酸、ステアリン酸、オレイン酸、イソステアリン酸、cis−11−エイコセン酸などの脂肪酸類;ラウリルアルコール、セタノール、ステアリルアルコールなどの高級アルコール類;ミリスチン酸イソプロピル、パルミチン酸イソプロピル、オレイン酸ブチル、2−エチルヘキシルグリセライド、高級脂肪酸オクチルドデシル(ステアリン酸オクチルドデシル等)などの合成エステル類及び合成トリグリセライド類等が挙げられる。 Here, as the oil component, for example, olive oil, jojoba oil, castor oil, soybean oil, rice oil, rice germ oil, palm oil, palm oil, cacao oil, meadow foam oil, sheer butter, tea tree oil, avocado oil, Oils derived from plants such as macadamia nut oil and plant-derived squalane; Fats derived from animals such as mink oil and turtle oil; waxes such as beeswax, carnauba wax, rice wax, lanolin; liquid paraffin, petrolatum, paraffin wax, squalane, etc. Hydrocarbons; fatty acids such as myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, cis-11-eicosenoic acid; higher alcohols such as lauryl alcohol, cetanol, stearyl alcohol; isopropyl myristate, palmitic acid Isopropyl, me Butyl phosphate, 2-ethylhexyl glycerides, higher fatty acid octyldodecyl (octyl stearate dodecyl and the like), and the synthetic esters and synthetic triglycerides such like.
界面活性剤としては,例えばポリオキシエチレンアルキルエーテル、ポリオキシエチレン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビトール脂肪酸エステルなどの非イオン界面活性剤;脂肪酸塩、アルキル硫酸塩、アルキルベンゼンスルホン酸塩、ポリオキシエチレンアルキルエーテル硫酸塩、ポリオキシエチレン脂肪酸アミン硫酸塩、ポリオキシエチレンアルキルフェニルエーテル硫酸塩、ポリオキシエチレンアルキルエーテル燐酸塩、α−スルホン化脂肪酸アルキルエステル塩、ポリオキシエチレンアルキルフェニルエーテル燐酸塩などのアニオン界面活性剤;第四級アンモニウム塩、第一級〜第三級脂肪酸アミン塩、トリアルキルベンジルアンモニウム塩、アルキルピリジニウム塩、2−アルキル−1−アルキル−1−ヒドロキシエチルイミダゾリニウム塩、N,N−ジアルキルモルフォルニウム塩、ポリエチレンポリアミン脂肪酸アミド塩などのカチオン界面活性剤;N,N−ジメチル−N−アルキル−N−カルボキシメチルアンモニオベタイン、N,N,N−トリアルキル−N−アルキレンアンモニオカルボキシベタイン、N−アシルアミドプロピル−N′,N′−ジメチル−N′−β−ヒドロキシプロピルアンモニオスルホベタインなどの両性界面活性剤等を使用することができる。
又、乳化剤乃至乳化助剤として、酵素処理ステビアなどのステビア誘導体、レシチン及びその誘導体、乳酸菌発酵米、乳酸菌発酵発芽米、乳酸菌発酵穀類(麦類、豆類、雑穀など)、ジュアゼイロ(Zizyphus juazeiro:Rhamnaceae)抽出物等を配合することもできる。
Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene Nonionic surfactants such as oxyethylene sorbitol fatty acid esters; fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty acid amine sulfates, polyoxyethylene alkyl phenyl ether sulfates, Polyoxyethylene alkyl ether phosphates, α-sulfonated fatty acid alkyl ester salts, polyoxyethylene alkyl phenyl ether phosphates, etc. ON surfactant: quaternary ammonium salt, primary to tertiary fatty acid amine salt, trialkylbenzylammonium salt, alkylpyridinium salt, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salt, N N, N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N, N, N-trialkyl-N-, N, N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine Amphoteric surfactants such as alkylene ammoniocarboxybetaine and N-acylamidopropyl-N ′, N′-dimethyl-N′-β-hydroxypropylammoniosulfobetaine can be used.
In addition, as emulsifiers or emulsifiers, stevia derivatives such as enzyme-treated stevia, lecithin and derivatives thereof, lactic acid bacteria fermented rice, lactic acid bacteria fermented germinated rice, lactic acid bacteria fermented cereals (wheat, beans, millet, etc.), juiziro (Rhamnaceae ) An extract or the like can also be blended.
保湿剤としては、例えばグリセリン、プロピレングリコール、ジプロピレングリコール、1,3−ブチレングリコール、ポリエチレングリコール、ソルビトール、キシリトール、ピロリドンカルボン酸ナトリウム、N−(3,4,5,6−テトラヒドロキシ−2−オキソヘキシル)ピログルタミン酸等があり、さらにトレハロース等の糖類、乳酸菌発酵米、ムコ多糖類(例えば、ヒアルロン酸及びその誘導体、コンドロイチン及びその誘導体、ヘパリン及びその誘導体など)、エラスチン及びその誘導体、コラーゲン及びその誘導体、加水分解シルク蛋白質、NMF関連物質、乳酸、尿素、高級脂肪酸オクチルドデシル、フィトステロール、大豆リン脂質、イソステアリン酸コレステリル、海藻抽出物、魚介類由来コラーゲン及びその誘導体、各種アミノ酸及びそれらの誘導体(例えばトリメチルグリシンなど)、スフィンゴ脂質、ビャッキュウ抽出物、豆乳発酵液、納豆エキス、米由来抽出物及びその発酵物等が挙げられる。 Examples of the humectant include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidonecarboxylate, N- (3,4,5,6-tetrahydroxy-2- Oxohexyl) pyroglutamic acid, saccharides such as trehalose, lactic acid bacteria fermented rice, mucopolysaccharides (eg, hyaluronic acid and derivatives thereof, chondroitin and derivatives thereof, heparin and derivatives thereof), elastin and derivatives thereof, collagen and Derivatives, hydrolyzed silk protein, NMF related substances, lactic acid, urea, higher fatty acid octyldodecyl, phytosterol, soybean phospholipid, cholesteryl isostearate, seaweed extract, seafood-derived collagen and its derivatives Various amino acids and their derivatives (such as trimethyl glycine, etc.), sphingolipids, Byakkyuu extract, soybean milk fermented liquor, natto extract, rice-derived extract and fermented, and the like.
増粘剤としては、例えばアルギン酸、寒天、カラギーナン、フコイダン等の褐藻、緑藻或いは紅藻由来成分、ビャッキュウ抽出物、ペクチン、ローカストビーンガム、アロエ多糖体等の多糖類、キサンタンガム、トラガントガム、グアーガム等のガム類、カルボキシメチルセルロース、ヒドロキシエチルセルロース等のセルロース誘導体、ポリビニルアルコール、ポリビニルピロリドン、カルボキシビニルポリマー、アクリル酸・メタクリル酸共重合体等の合成高分子類;ヒアルロン酸及びその誘導体、ポリグルタミン酸及びその誘導体、グルコシルトレハロースと加水分解水添デンプンを主体とする糖化合物等が挙げられる。 Examples of thickeners include, for example, brown algae such as alginic acid, agar, carrageenan, fucoidan, green algae or red algae-derived components, beech extract, pectin, locust bean gum, polysaccharides such as aloe polysaccharide, xanthan gum, tragacanth gum, guar gum, etc. Synthetic polymers such as gums, cellulose derivatives such as carboxymethylcellulose, hydroxyethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, acrylic acid / methacrylic acid copolymer; hyaluronic acid and its derivatives, polyglutamic acid and its derivatives, Examples thereof include sugar compounds mainly composed of glucosyl trehalose and hydrolyzed hydrogenated starch.
防腐・殺菌剤としては、例えば尿素;パラオキシ安息香酸メチル、パラオキシ安息香酸エチル、パラオキシ安息香酸プロピル、パラオキシ安息香酸ブチルなどのパラオキシ安息香酸エステル類;フェノキシエタノール、ジクロロフェン、ヘキサクロロフェン、塩酸クロルヘキシジン、塩化ベンザルコニウム、サリチル酸、エタノール、ウンデシレン酸、フェノール類、ジャーマル(イミダゾデイニールウレア)、1,2−ペンタンジオール、各種精油類、樹皮乾留物、プロポリスエキス、メチルイソチアゾリノン等がある。 Examples of the antiseptic / bactericidal agent include urea; paraoxybenzoates such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and butyl paraoxybenzoate; phenoxyethanol, dichlorophene, hexachlorophene, chlorhexidine hydrochloride, benzaza chloride Examples thereof include Luconium, Salicylic acid, Ethanol, Undecylenic acid, Phenols, Jamal (Imidazodenyl urea), 1,2-pentanediol, various essential oils, bark dry product, propolis extract, methylisothiazolinone.
粉体成分としては、例えばセリサイト、酸化チタン、タルク、カオリン、ベントナイト、酸化亜鉛、炭酸マグネシウム、酸化マグネシウム、酸化ジルコニウム、硫酸バリウム、無水ケイ酸、雲母、6−又は12−ナイロンパウダー、ポリエチレンパウダー、シルクパウダー、セルロース系パウダー、穀類(米、麦、トウモロコシ、キビなど)のパウダー、豆類(大豆、小豆など)のパウダー等がある。 Examples of the powder component include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, 6- or 12-nylon powder, polyethylene powder. Silk powder, cellulosic powder, grains (rice, wheat, corn, millet, etc.) powder, beans (soybean, red beans, etc.) powder, and the like.
紫外線吸収剤としては、例えばパラアミノ安息香酸エチル、パラジメチルアミノ安息香酸エチルヘキシル、サリチル酸アミル及びその誘導体、パラメトキシ桂皮酸2−エチルヘキシル、桂皮酸オクチル、オキシベンゾン、2,4−ジヒドロキシベンゾフェノン、2−ヒドロキシ−4−メトキシベンゾフェノン−5−スルホン酸塩、4−ターシャリーブチル−4−メトキシベンゾイルメタン、2−(2−ヒドロキシ−5−メチルフェニル)ベンゾトリアゾール、ウロカニン酸、ウロカニン酸エチル、アロエ抽出物等がある。 Examples of the ultraviolet absorber include ethyl paraaminobenzoate, ethylhexyl paradimethylaminobenzoate, amyl salicylate and derivatives thereof, 2-ethylhexyl paramethoxycinnamate, octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, 2-hydroxy-4 -Methoxybenzophenone-5-sulfonate, 4-tertiarybutyl-4-methoxybenzoylmethane, 2- (2-hydroxy-5-methylphenyl) benzotriazole, urocanic acid, ethyl urocanate, aloe extract, etc. .
生理活性成分としては、例えば美白成分として、t−シクロアミノ酸誘導体、コウジ酸及びその誘導体、アスコルビン酸及びその誘導体、ハイドロキノン誘導体、エラグ酸及びその誘導体、レゾルシノール誘導体、ソウハクヒ抽出物、ユキノシタ抽出物、米糠抽出物、米糠抽出物加水分解物、乳酸菌発酵米、乳酸菌発酵発芽米、乳酸菌発酵穀類(麦類、豆類、雑穀類)、白芥子加水分解抽出物、ムラサキシキブ抽出物、ハスの実発酵物、党参抽出物、パンダヌス・アマリリフォリウス(Pandanus amaryllifolius Roxb.)抽出物、アルカンジェリシア・フラバ(Arcangelicia flava Merrilli)抽出物、カミツレ抽出物(商品名:カモミラET)、ジンコウ抽出物、ハマメリス抽出物、イタドリ抽出物、サワヒヨドリ抽出物、甘草抽出物、フキタンポポ抽出物、アルテア抽出物、ゲンノショウコ抽出物、ユキノシタ抽出物、ナツメ抽出物、シャクヤク抽出物、トウキ抽出物、モモ抽出物、柑橘類(ミカン、ユズ、ダイダイなど)の抽出物、緑藻類、紅藻類又は褐藻類の海藻の抽出物、アマモ等の海草の抽出物、リノール酸及びその誘導体もしくは加工物(例えばリポソーム化リノール酸など)、2,5−ジヒドロキシ安息香酸誘導体等が、又皮膚老化防止・美肌化・シワ防止 成分として、動物又は魚由来のコラーゲン及びその誘導体、エラスチン及びその誘導体、ニコチン酸及びその誘導体、グリチルリチン酸及びその誘導体(ジカリウム塩等)、t−シクロアミノ酸誘導体、ビタミンA及びその誘導体、ビタミンE及びその誘導体、アラントイン、α−ヒドロキシ酸類、ジイソプロピルアミンジクロロアセテート、γ−アミノ−β−ヒドロキシ酪酸、コエンザイムQ−10、α−リポ酸、ゲンチアナエキス、甘草エキス、ハトムギエキス、カミツレエキス、ニンジンエキス、アロエエキスなどの生薬抽出エキス、米抽出物加水分解物、低アレルゲン米抽出物加水分解物、米糠抽出物加水分解物、米発酵エキス、緑藻類、紅藻類又は褐藻類の海藻の抽出物、アマモ等の海草の抽出物、ソウハクヒエキス、ジュアゼイロ(Zizyphus juazeiro)抽出物、ブナ抽出物、キダチアロエ抽出物、マンネンロウ抽出物、イチョウ抽出物、スギナ抽出物、ベニバナ抽出物、オタネニンジン抽出物、セイヨウニワトコ抽出物、ハゴロモグサ抽出物、レンゲ抽出物、マンゴー抽出物、チェリモヤ抽出物、マンゴスチン抽出物、タベブイア・インペチギノサ抽出物、柑橘類(ミカン、ユズ、ダイダイなど)の抽出物、酵母抽出物、卵殻膜抽出タンパク質、デオキシリボ核酸カリウム塩、スフィンゴ脂質、ハス発酵液、紫蘭根抽出物、ムラサキシキブ抽出物、イネ抽出物、サンゴ草抽出物、花粉荷エキス、ユリ全草抽出物等がある。 Examples of physiologically active ingredients include whitening ingredients such as t-cycloamino acid derivatives, kojic acid and derivatives thereof, ascorbic acid and derivatives thereof, hydroquinone derivatives, ellagic acid and derivatives thereof, resorcinol derivatives, sucha akuhi extract, yukinoshita extract, rice bran Extract, rice bran extract hydrolyzate, lactic acid bacteria fermented rice, lactic acid bacteria fermented germinated rice, lactic acid bacteria fermented cereals (wheat, legumes, minor grains), white coconut hydrolyzed extract, murasakixikibu extract, lotus seed fermented product, party participation Extract, Pandanus amaryllifolius Roxb extract, Arcangelicia flava Merrilli extract, chamomile extract (trade name: Chamomile ET), ginger extract Japanese knotweed extract, Sahweed extract, licorice extract, dandelion extract, artea extract, genus shochu extract, saxifrage extract, jujube extract, peonies extract, suzuki extract, peach extract, citrus (mandarin orange, citron, Extract, etc.), green algae, red algae or brown algae seaweed extract, seaweed extract such as sea eel, linoleic acid and its derivatives or processed products (eg liposomal linoleic acid), 2,5-dihydroxy Benzoic acid derivatives, etc., as skin aging prevention, skin beautification and wrinkle prevention ingredients, animal and fish-derived collagen and derivatives thereof, elastin and derivatives thereof, nicotinic acid and derivatives thereof, glycyrrhizic acid and derivatives thereof (dipotassium salt, etc.) , T-cycloamino acid derivatives, vitamin A and its derivatives, vitamin E and its Derivatives, allantoin, α-hydroxy acids, diisopropylamine dichloroacetate, γ-amino-β-hydroxybutyric acid, coenzyme Q-10, α-lipoic acid, gentian extract, licorice extract, pearl barley extract, chamomile extract, carrot extract, aloe extract Herbal extract, rice extract hydrolyzate, low allergen rice extract hydrolyzate, rice bran extract hydrolyzate, rice fermented extract, green algae, red algae or brown algae seaweed extract, seaweed etc. Extract, Sahakuhi extract, Zizyphus juazeiro extract, Beech extract, Kidachi aloe extract, Mannenrou extract, Ginkgo biloba extract, Horsetail extract, Safflower extract, Panax ginseng extract, Elderberry extract, Hagoromogusa extract , Lotus extract, ma Go extract, cherimoya extract, mangosteen extract, tabebuia impetiginosa extract, citrus (citrus, yuzu, Daidai, etc.) extract, yeast extract, eggshell membrane extract protein, deoxyribonucleic acid potassium salt, sphingolipid, lotus fermentation Liquid, purple orchid root extract, murasakixikib extract, rice extract, coral grass extract, pollen extract, lily whole plant extract and the like.
上記のコウジ酸誘導体としては、例えばコウジ酸モノブチレート、コウジ酸モノカプレート、コウジ酸モノパルミテート、コウジ酸ジブチレートなどのコウジ酸エステル類、コウジ酸エーテル類、コウジ酸グルコシドなどのコウジ酸糖誘導体等が、アスコルビン酸誘導体としては、例えばL−アスコルビン酸−2−リン酸エステルナトリウム、L−アスコルビン酸−2−リン酸エステルマグネシウム、L−アスコルビン酸−2−硫酸エステルナトリウム、L−アスコルビン酸−2−硫酸エステルマグネシウムなどのアスコルビン酸エステル塩類、L−アスコルビン酸−2−グルコシド(2−O−α−D−グルコピラノシル−L−アスコルビン酸)、L−アスコルビン酸−5−グルコシド(5−O−α−D−グルコピラノシル−L−アスコルビン酸)などのアスコルビン酸糖誘導体、それらアスコルビン酸糖誘導体の6位アシル化物(アシル基は、ヘキサノイル基、オクタノイル基、デカノイル基など)、L−アスコルビン酸テトライソパルミチン酸エステル、L−アスコルビン酸テトララウリン酸エステルなどのL−アスコルビン酸テトラ脂肪酸エステル類、3−O−エチルアスコルビン酸、L−アスコルビン酸−2−リン酸−6−O−パルミテートナトリウム等が、ハイドロキノン誘導体としては、アルブチン(ハイドロキノン−β−D−グルコピラノシド)、α−アルブチン(ハイドロキノン−α−D−グルコピラノシド)等が、レゾルシノール誘導体としては、例えば4−n−ブチルレゾルシノール、4−イソアミルレゾルシノール等が、2,5−ジヒドロキシ安息香酸誘導体としては、例えば2,5−ジアセトキシ安息香酸、2−アセトキシ−5−ヒドロキシ安息香酸、2−ヒドロキシ−5−プロピオニルオキシ安息香酸等が、ニコチン酸誘導体としては、例えばニコチン酸アミド、ニコチン酸ベンジル等が、ビタミンE誘導体としては、例えばビタミンEニコチネート、ビタミンEリノレート、ビタミンEリン酸エステルナトリウム塩等が、α−ヒドロキシ酸としては、例えば乳酸、リンゴ酸、コハク酸、クエン酸、α−ヒドロキシオクタン酸等がある。 Examples of the kojic acid derivative include kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid esters such as kojic acid dibutyrate, kojic acid sugar derivatives such as kojic acid ethers, and kojic acid glucoside. However, as the ascorbic acid derivatives, for example, L-ascorbic acid-2-phosphate sodium, L-ascorbic acid-2-phosphate magnesium, L-ascorbic acid-2-sulfate sodium, L-ascorbic acid-2 -Ascorbic acid ester salts such as magnesium sulfate, L-ascorbic acid-2-glucoside (2-O-α-D-glucopyranosyl-L-ascorbic acid), L-ascorbic acid-5-glucoside (5-O-α) -D-glucopyranosyl-L-ascorbine Acid) ascorbic acid sugar derivatives, acylated 6-positions of these ascorbic acid sugar derivatives (acyl groups are hexanoyl, octanoyl, decanoyl, etc.), L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetra L-ascorbic acid tetrafatty acid esters such as lauric acid ester, 3-O-ethylascorbic acid, L-ascorbic acid-2-phosphate-6-O-palmitate sodium and the like are hydroquinone derivatives such as arbutin (hydroquinone). -Β-D-glucopyranoside), α-arbutin (hydroquinone-α-D-glucopyranoside) and the like, and as resorcinol derivatives, for example, 4-n-butylresorcinol, 4-isoamylresorcinol and the like are 2,5-dihydroxybenzoic acid. Derivatives and For example, 2,5-diacetoxybenzoic acid, 2-acetoxy-5-hydroxybenzoic acid, 2-hydroxy-5-propionyloxybenzoic acid, etc., and nicotinic acid derivatives include, for example, nicotinic acid amide, nicotinic acid benzyl, etc. However, examples of vitamin E derivatives include vitamin E nicotinate, vitamin E linoleate, and sodium salt of vitamin E phosphate. Examples of α-hydroxy acids include lactic acid, malic acid, succinic acid, citric acid, and α-hydroxyoctane. There are acids.
抗炎症剤としては、グリチルリチン酸、アラントイン、ゲンチアナ根抽出物、タベブイア・インペチギノサ(Tabebuia impetiginosa)抽出物等がある。 Examples of the anti-inflammatory agent include glycyrrhizic acid, allantoin, gentian root extract, and Tabebuia impetiginosa extract.
抗酸化剤としては、例えばブチルヒドロキシアニソール、ブチルヒドロキシトルエン、没食子酸プロピル、ビタミンE及びその誘導体、ユビデカキノン(ユビキノン)、ルチン、ルチングルコシド、白芥子抽出物、イネ抽出物、ムラサキシキブ抽出物、シラカバ抽出物、ハマメリス抽出物、ウーロン茶抽出物、黒豆加水分解抽出液、ハゴロモグサ抽出液等がある。 Antioxidants include, for example, butylhydroxyanisole, butylhydroxytoluene, propyl gallate, vitamin E and its derivatives, ubidecaquinone (ubiquinone), rutin, rutin glucoside, white coconut extract, rice extract, murasakikibu extract, birch extract Products, hamamelis extract, oolong tea extract, black bean hydrolyzed extract, hagoromogusa extract and the like.
又コラーゲン合成促進剤としては、例えばアスコルビン酸及びその誘導体(L−アスコルビン酸−2−リン酸エステルマグネシウム、L−アスコルビン酸−2−グルコシドなど)、米抽出物加水分解物、ニンジンエキス、ニンジン発酵物、アマモ抽出物などが挙げられる。 Examples of the collagen synthesis promoter include ascorbic acid and derivatives thereof (such as L-ascorbic acid-2-phosphate magnesium and L-ascorbic acid-2-glucoside), rice extract hydrolyzate, carrot extract, carrot fermentation Products, eel extracts and the like.
次に、製造例、試験例及び実施例(化粧料の処方例)を挙げて本発明をさらに具体的に説明するが、本発明はそれらに限定されるものではない。なお、以下に於いて、部はすべて重量部を、又%はすべて重量%を意味する。 Next, the present invention will be described more specifically with reference to production examples, test examples, and examples (formulation examples of cosmetics), but the present invention is not limited thereto. In the following, all parts are parts by weight, and all% are% by weight.
製造例1.水ナス搾汁液の調製(1)
水ナス(泉州産。以下同じ)の果実2800gをフードプロセッサーでペースト状にし、さらにそれを圧搾して得られた液をろ過し、黄褐色澄明の水ナス搾汁液1980gを得た(固形分濃度3.70%)。
Production Example 1 Preparation of water eggplant juice (1)
2800 g of water eggplant (from Quanzhou, the same applies hereinafter) was made into a paste with a food processor, and the resulting liquid was further filtered to obtain 1980 g of a tan clear water eggplant juice (solid concentration) 3.70%).
製造例2.水ナス搾汁液の調製(2)
水ナス果実2800gをフードプロセッサーでペースト状にし、さらにそれを圧搾して得られた液を活性炭で脱色処理を行い、無色透明の水ナス搾汁液1700gを得た(固形分3.51%)。
Production Example 2 Preparation of water eggplant juice (2)
2800 g of water eggplant fruit was made into a paste using a food processor, and the resulting liquid was decolorized with activated carbon to obtain 1700 g of a colorless and transparent water eggplant juice (solid content: 3.51%).
製造例3.水ナス果実エキスの調製(1)
水ナス果実の乾燥物100gに精製水1000gを混合し、40℃で4時間抽出を行った後ろ過し、黄色澄明の水ナス果実抽出液820gを得た(固形分濃度1.31%)。
Production Example 3 Preparation of water eggplant fruit extract (1)
Purified water (1000 g) was mixed with 100 g of dried eggplant fruit and extracted at 40 ° C. for 4 hours, followed by filtration to obtain 820 g of a clear yellow eggplant fruit extract (solid content concentration: 1.31%).
製造例4.水ナス果実エキスの調製(2)
水ナス果実の乾燥物100gに精製水と1,3‐ブチレングリコールの7:3(重量比)混液1200gを混合し、80℃で2時間抽出を行った後ろ過し、黄褐色澄明の水ナス果実抽出液910gを得た(固形分濃度1.01%)。
Production Example 4 Preparation of water eggplant fruit extract (2)
100 g of dried eggplant fruit was mixed with 1200 g of a 7: 3 (weight ratio) mixture of purified water and 1,3-butylene glycol, followed by extraction at 80 ° C. for 2 hours, followed by filtration, 910 g of a fruit extract was obtained (solid content concentration 1.01%).
製造例5.水ナス果実エキスの調製(3)
水ナス果実の乾燥物100gに精製水とエタノールの1:1(重量比)混液800gを混合し、4℃で72時間抽出を行った後ろ過し、淡黄色澄明の水ナス果実抽出液650gを得た(固形分濃度0.77%)。
Production Example 5 Preparation of water eggplant fruit extract (3)
100 g of dried eggplant fruit was mixed with 800 g of a 1: 1 (weight ratio) mixture of purified water and ethanol, extracted at 4 ° C. for 72 hours, filtered, and 650 g of a light yellow clear water eggplant fruit extract was obtained. Obtained (solid content concentration 0.77%).
製造例6.水ナス果実エキスの調製(4)
水ナス果実の乾燥物100gを粉砕機で粉砕した後篩別し、平均粒径20μmの水ナス果実乾燥物粉末75gを得た。
Production Example 6 Preparation of water eggplant fruit extract (4)
100 g of dried eggplant fruit was pulverized with a pulverizer and sieved to obtain 75 g of dried eggplant fruit powder having an average particle size of 20 μm.
製造例7.水ナス搾汁液粉末の調製
製造例1と同様にして得た水ナス搾汁液500gを凍結乾燥した後粉砕し、黄褐色の水ナス搾汁液粉末16.8gを得た。
Production Example 7 Preparation of water eggplant juice liquid powder 500 g of water eggplant juice liquid obtained in the same manner as in Production Example 1 was freeze-dried and then pulverized to obtain 16.8 g of tan brown water eggplant juice liquid powder.
比較製造例1.長ナス搾汁液の調製
製造例1において、水ナスに代えて長ナス2800gを使用する他は製造例1と同様にして、長ナス搾汁液1020gを得た(固形分3.15%)。
Comparative Production Example 1 Preparation of Long Eggplant Juice Liquid In Production Example 1, 1020 g of long eggplant juice was obtained in the same manner as in Production Example 1 except that 2800 g of long eggplant was used instead of water eggplant (solid content 3.15%).
比較製造例2.米ナス搾汁液の調製。
製造例1において、水ナスに代えて米ナス2800gを使用する他は製造例1と同様にして、米ナス搾汁液980gを得た(固形分3.20%)。
Comparative Production Example 2 Preparation of rice eggplant juice.
In Production Example 1, 980 g of rice eggplant juice was obtained in the same manner as in Production Example 1 except that 2800 g of rice eggplant was used instead of water eggplant (solid content 3.20%).
実施例1.クリーム
[A成分] 部
流動パラフィン 5.0
ヘキサラン (注1) 4.0
パラフィン 5.0
グリセリルモノステアレート 2.0
ポリオキシエチレン(20)ソルビタンモノステアレート 6.0
ブチルパラベン 0.1
(注1)株式会社テクノーブル製 トリオクタン酸グリセリル
[B成分]
製造例1の水ナス搾汁液 10.0
グリセリン 5.0
メチルパラベン 0.1
モイストン・C (注2) 1.0
精製水 全量が100部となる量
(注2)株式会社テクノーブル製 NMF成分
[C成分]
香料 適量
上記のA成分とB成分をそれぞれ80℃以上に加熱した後、攪拌混合した。これを50℃まで冷却した後、C成分を加えてさらに攪拌混合してクリームを得た。
Example 1. Cream [component A] part Liquid paraffin 5.0
Hexalan (Note 1) 4.0
Paraffin 5.0
Glyceryl monostearate 2.0
Polyoxyethylene (20) sorbitan monostearate 6.0
Butylparaben 0.1
(Note 1) Technoble Co., Ltd. glyceryl trioctanoate [component B]
Juice eggplant juice from Production Example 10.0
Glycerin 5.0
Methylparaben 0.1
Moiston C (Note 2) 1.0
Amount of purified water totaling 100 parts
(Note 2) NMF component manufactured by Technoble Co., Ltd.
[C component]
Fragrance Appropriate amount Each of the above components A and B was heated to 80 ° C. or higher, and then mixed by stirring. After this was cooled to 50 ° C., component C was added and further stirred and mixed to obtain a cream.
実施例2.クリーム
実施例1のB成分中製造例1の水ナス搾汁液に代えて製造例2の水ナス搾汁液を用いるほかは実施例1と同様にしてクリームを得た。
Example 2 Cream A cream was obtained in the same manner as in Example 1 except that the water eggplant juice of Production Example 2 was used instead of the water eggplant juice of Production Example 1 in the component B of Example 1.
実施例3.乳液
[A成分] 部
流動パラフィン 6.0
ヘキサラン 4.0
ホホバ油 1.0
ポリオキシエチレン(20)ソルビタンモノステアレート 2.0
大豆レシチン 1.5
メチルパラベン 0.15
エチルパラベン 0.03
[B成分]
製造例1の水ナス搾汁液 10.0
グリセリン 3.0
1、3−ブチレングリコール 2.0
カルボキシメチルセルロース 0.3
ヒアルロン酸ナトリウム 0.01
精製水 全量が100部となる量
[C成分]
香料 適量
上記のA成分とB成分をそれぞれ80℃以上に加熱した後、攪拌混合した。これを50℃まで冷却した後、C成分を加えてさらに攪拌混合して乳液を得た。
Example 3 Emulsion [component A] part liquid paraffin 6.0
Hexalan 4.0
Jojoba oil 1.0
Polyoxyethylene (20) sorbitan monostearate 2.0
Soy lecithin 1.5
Methylparaben 0.15
Ethylparaben 0.03
[B component]
Juice eggplant juice from Production Example 10.0
Glycerin 3.0
1,3-butylene glycol 2.0
Carboxymethylcellulose 0.3
Sodium hyaluronate 0.01
Purified water Amount of 100 parts [component C]
Fragrance Appropriate amount Each of the above components A and B was heated to 80 ° C. or higher, and then mixed by stirring. After cooling this to 50 ° C., component C was added and further stirred and mixed to obtain an emulsion.
実施例4.ローション
[成分]
部
製造例2の水ナス搾汁液 10.0
エタノール 10.0
グリセリン 3.0
1、3−ブチレングリコール 2.0
メチルパラベン 0.2
クエン酸 0.1
クエン酸ナトリウム 0.3
カルボキシビニルポリマー 0.1
香料 適量
水酸化カリウム 適量
精製水 全量が100部となる量
上記の成分を混合してローションを得た。
Example 4 Lotion [Ingredient]
Part Juice eggplant juice of Production Example 2 10.0
Ethanol 10.0
Glycerin 3.0
1,3-butylene glycol 2.0
Methylparaben 0.2
Citric acid 0.1
Sodium citrate 0.3
Carboxyvinyl polymer 0.1
Perfume Appropriate amount Potassium hydroxide Appropriate amount Purified water An amount that makes the total amount 100 parts The above ingredients were mixed to obtain a lotion.
実施例5.化粧水
[A成分] 部
オリーブ油 1.0
ポリオキシエチレン(5.5)セチルエーテル 0.5
ブチルパラベン 0.1
[B成分]
製造例2の水ナス搾汁液 10.0
エタノール 5.0
グリセリン 5.0
1,3−ブチレングリコール 5.0
メチルパラベン 0.1
水酸化カリウム 適量
精製水 全量が100部となる量
[C成分]
香料 適量
A成分及びB成分をそれぞれ80℃以上に加温後、A成分にB成分を加えて攪拌し、さらにヒスコトロン(5000rpm)で2分間ホモジナイズを行った。これを50℃まで冷却した後、C成分を加えて攪拌混合し、さらに30℃以下まで冷却して化粧水を得た。
Example 5 FIG. Lotion [component A] part olive oil 1.0
Polyoxyethylene (5.5) cetyl ether 0.5
Butylparaben 0.1
[B component]
Juice eggplant juice of Production Example 2 10.0
Ethanol 5.0
Glycerin 5.0
1,3-butylene glycol 5.0
Methylparaben 0.1
Potassium hydroxide Appropriate amount Purified water Amount that makes the total amount 100 parts [Component C]
Perfume Appropriate A component and B component were each heated to 80 ° C. or higher, then B component was added to A component and stirred, and further homogenized with Hiscotron (5000 rpm) for 2 minutes. After cooling this to 50 degreeC, C component was added and stirred and mixed, and also it cooled to 30 degrees C or less, and the lotion was obtained.
実施例6.乳液
実施例3のB成分中、製造例1の水ナス搾汁液に代えて製造例3の水ナス果実抽出液を用いるほかは実施例3と同様にして乳液を得た。
Example 6 Emulsion An emulsion was obtained in the same manner as in Example 3 except that the water eggplant juice extract of Production Example 3 was used instead of the water eggplant juice of Production Example 1 in the component B of Example 3.
実施例7.乳液
実施例3のB成分中、製造例1の水ナス搾汁液に代えて製造例4の水ナス果実抽出液を用いるほかは実施例3と同様にして乳液を得た。
Example 7 Emulsion An emulsion was obtained in the same manner as in Example 3 except that the water eggplant fruit extract of Production Example 4 was used instead of the water eggplant juice of Production Example 1 in the component B of Example 3.
実施例8.乳液
実施例3のB成分中、製造例1の水ナス搾汁液に代えて製造例5の水ナス果実抽出液を用いるほかは実施例3と同様にして乳液を得た。
Example 8 FIG. Emulsion An emulsion was obtained in the same manner as in Example 3 except that the water eggplant fruit extract of Production Example 5 was used instead of the water eggplant juice of Production Example 1 in the component B of Example 3.
実施例9.乳液
[A成分] 部
流動パラフィン 6.0
ヘキサラン 4.0
ホホバ油 1.0
ポリオキシエチレン(20)ソルビタンモノステアレート 2.0
大豆レシチン 1.5
メチルパラベン 0.15
エチルパラベン 0.03
[B成分]
製造例1の水ナス搾汁液 10.0
L−アスコルビン酸−2−グルコシド 2.0
グリセリン 3.0
1、3−ブチレングリコール 2.0
カルボキシメチルセルロース 0.3
ヒアルロン酸ナトリウム 0.01
水酸化カリウ 適量
精製水 全量が100部となる量
[C成分]
香料 適量
上記のA成分とB成分をそれぞれ80℃以上に加熱した後、攪拌混合した。これを50℃まで冷却した後、C成分を加えてさらに攪拌混合して乳液を得た。
Example 9 Emulsion [component A] part liquid paraffin 6.0
Hexalan 4.0
Jojoba oil 1.0
Polyoxyethylene (20) sorbitan monostearate 2.0
Soy lecithin 1.5
Methylparaben 0.15
Ethylparaben 0.03
[B component]
Juice eggplant juice from Production Example 10.0
L-ascorbic acid-2-glucoside 2.0
Glycerin 3.0
1,3-butylene glycol 2.0
Carboxymethylcellulose 0.3
Sodium hyaluronate 0.01
Potassium hydroxide appropriate amount Purified water Amount that makes 100 parts in total [Component C]
Fragrance Appropriate amount Each of the above components A and B was heated to 80 ° C. or higher, and then mixed by stirring. After cooling this to 50 ° C., component C was added and further stirred and mixed to obtain an emulsion.
実施例10.乳液
実施例9のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えてL−アスコルビン酸−2−リン酸エステルマグネシウム2.0部を用いるほかは実施例9と同様にして乳液を得た。
Example 10 Emulsion Other than using 2.0 parts of L-ascorbic acid-2-phosphate magnesium in place of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 parts of potassium hydroxide in the component B of Example 9 Obtained an emulsion in the same manner as in Example 9.
実施例11.乳液
実施例9のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えてL−アスコルビン酸−2−リン酸エステルナトリウム2.0部を用いるほかは実施例9と同様にして乳液を得た。
Example 11 Emulsion In addition to using 2.0 parts of L-ascorbic acid-2-phosphate and 2.0 parts of sodium L-ascorbic acid-2-phosphate in place of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 parts of potassium hydroxide in the component B of Example 9 Obtained an emulsion in the same manner as in Example 9.
実施例12.乳液
実施例9のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えてアルブチン2.0部を用いるほかは実施例9と同様にして乳液を得た。
Example 12 Emulsion In the component B of Example 9, the emulsion was prepared in the same manner as in Example 9, except that 2.0 parts of arbutin was used instead of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 parts of potassium hydroxide. Obtained.
実施例13.乳液
実施例9のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えて米糠抽出物加水分解物(株式会社テクノーブル製、商品名「グレイスノウ*雪*HP」、固形分濃度3.5%)5.0部を用いるほかは実施例9と同様にして乳液を得た。
Example 13 Latex In the component B of Example 9, instead of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 part of potassium hydroxide, a rice bran extract hydrolyzate (trade name “Grace Snow” manufactured by Technoble Co., Ltd.) An emulsion was obtained in the same manner as in Example 9 except that 5.0 parts of * Snow * HP ", solid content concentration 3.5%) were used.
実施例14.乳液
実施例9のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えて白芥子(Brassica Alba)種子抽出物(株式会社テクノーブル製、商品名「シナブランカ−WH」、固形分濃度1.0%)5.0部を用いるほかは実施例9と同様にして乳液を得た。
Example 14 Latex In the component B of Example 9, in place of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 part of potassium hydroxide, white seed (Brassica Alba) seed extract (trade name, manufactured by Technoble Co., Ltd.) An emulsion was obtained in the same manner as in Example 9 except that 5.0 parts of “Sinablanca-WH” (solid content concentration 1.0%) were used.
実施例15.乳液
実施例9のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えてγ−アミノ−β−ヒドロキシ酪酸1.0部を用いるほかは実施例9と同様にして乳液を得た。
Example 15. Emulsion Example 9 except for using 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 part of potassium hydroxide in the component B of Example 9 except that 1.0 part of γ-amino-β-hydroxybutyric acid is used. In the same manner as in No. 9, an emulsion was obtained.
実施例16.乳液
実施例9のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えて米抽出物加水分解物(株式会社テクノーブル製、商品名「オリゼノーブル」、固形分濃度1.5%)5.0部を用いるほかは実施例9と同様にして乳液を得た。
Example 16 Latex In the component B of Example 9, instead of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 part of potassium hydroxide, a rice extract hydrolyzate (trade name “Oryzenoble, manufactured by Technoble Co., Ltd.) A solid emulsion was obtained in the same manner as in Example 9 except that 5.0 parts of a solid content concentration of 1.5% was used.
実施例17.ローション
[成分] 部
製造例2の水ナス搾汁液 3.0
L−アスコルビン酸 −2−グルコシド 2.0
エタノール 10.0
グリセリン 3.0
1,3−ブチレングリコール 2.0
メチルパラベン 0.2
クエン酸 0.1
クエン酸ナトリウム 0.3
アルギン酸ナトリウム 0.1
水酸化カリウム 適量
香料 適量
精製水 全量が100部となる量
上記の成分を混合してローションを得た。
Example 17. Lotion [component] part water eggplant juice of production example 2 3.0
L-ascorbic acid-2-glucoside 2.0
Ethanol 10.0
Glycerin 3.0
1,3-butylene glycol 2.0
Methylparaben 0.2
Citric acid 0.1
Sodium citrate 0.3
Sodium alginate 0.1
Potassium hydroxide Appropriate amount Perfume Appropriate amount Purified water An amount that makes the total amount 100 parts The above ingredients were mixed to obtain a lotion.
実施例18.プレストパウダー
[A成分] 部
ベンガラ 0.5
黄酸化鉄 1.5
黒酸化鉄 0.1
酸化チタン 10.0
6−ナイロンパウダー 4.0
セリサイト 全量が100部となる量
マイカ 23.0
タルク 25.0
製造例6の水ナス果実乾燥物粉末 0.1
[B成分]
スクワラン 1.0
メチルポリシロキサン 4.0
プロピルパラベン 0.1
デヒドロ酢酸 0.1
流動パラフィン 2.0
香料 適量
上記のA成分とB成分をそれぞれ混合攪拌し混合した後、200メッシュのタイラーメッシュの篩にかけ、得られた混合粉末を金型に打型してプレストパウダーを得た。
Example 18 Pressed powder [A component] Part Bengala 0.5
Yellow iron oxide 1.5
Black iron oxide 0.1
Titanium oxide 10.0
6-Nylon powder 4.0
Amount that makes 100 parts of sericite Mica 23.0
Talc 25.0
Mizu eggplant fruit dried product powder of Production Example 6 0.1
[B component]
Squalane 1.0
Methylpolysiloxane 4.0
Propylparaben 0.1
Dehydroacetic acid 0.1
Liquid paraffin 2.0
Fragrance Appropriate Amounts The above A component and B component were mixed and stirred, mixed, then passed through a 200 mesh Tyler mesh sieve, and the resulting mixed powder was cast into a mold to obtain a pressed powder.
実施例19.リキッドファンデーション
[A成分] 部
ステアリン酸 2.4
モノステアリン酸プロピレングリコール 2.0
セトステアリルアルコール 0.2
液状ラノリン 2.0
流動パラフィン 3.0
ミリスチン酸イソプロピル 8.5
プロピルパラベン 0.05
[B成分]
製造例1の水ナス搾汁液 5.0
カルボキシメチルセルロースナトリウム 0.2
ベントナイト 0.5
プロピレングリコール 4.0
トリエタノールアミン 1.1
メチルパラベン 0.1
精製水 全量が100部となる量
[C成分]
酸化チタン 8.0
タルク 4.0
着色顔料 適量
上記のA成分とB成分をそれぞれ加温した後混合攪拌した。これを再加温し、上記のC成分を添加して型に流し込み、室温になるまで攪拌してリキッドファンデーションを得た。
Example 19. Liquid foundation [component A] part Stearic acid 2.4
Propylene glycol monostearate 2.0
Cetostearyl alcohol 0.2
Liquid lanolin 2.0
Liquid paraffin 3.0
Isopropyl myristate 8.5
Propylparaben 0.05
[B component]
Water eggplant juice from Production Example 1 5.0
Sodium carboxymethylcellulose 0.2
Bentonite 0.5
Propylene glycol 4.0
Triethanolamine 1.1
Methylparaben 0.1
Purified water Amount that makes the total amount 100 parts [C component]
Titanium oxide 8.0
Talc 4.0
Coloring pigment appropriate amount The components A and B were heated and mixed and stirred. This was reheated, the above C component was added, poured into a mold, and stirred until it reached room temperature to obtain a liquid foundation.
実施例20.クリームファンデーション
[A成分] 部
ステアリン酸 5.0
セタノール 2.0
モノステアリン酸グリセリル 3.0
流動パラフィン 5.0
スクワラン 3.0
ミリスチン酸イソプロピル 8.0
ポリオキシエチレン(20)モノステアリン酸グリセリル 2.0
プロピルパラベン 0.1
[B成分]
製造例2の水ナス搾汁液 5.0
ソルビトール 3.0
1,3−ブチレングリコール 5.0
トリエタノールアミン 1.5
メチルパラベン 0.1
精製水 全量が100部となる量
[C成分]
酸化チタン 8.0
タルク 2.0
カオリン 5.0
ベントナイト 1.0
着色顔料 適量
[D成分]
香料 0.3
C成分を混合し、粉砕機で粉砕した。B成分を混合し、これに粉砕したC成分を加え、コロイドミルで均一分散させた。A成分及び均一分散させたB、C成分をそれぞれ80℃に加温後、B、C成分にA成分を攪拌しながら加え、さらにヒスコトロン(5000rpm)で2分間ホモジナイズを行った。これを50℃まで冷却した後、D成分を加えて攪拌混合し、さらに攪拌しながら30℃以下まで冷却してクリームファンデーションを得た。
Example 20. Cream foundation [component A] part Stearic acid 5.0
Cetanol 2.0
Glyceryl monostearate 3.0
Liquid paraffin 5.0
Squalane 3.0
Isopropyl myristate 8.0
Polyoxyethylene (20) glyceryl monostearate 2.0
Propylparaben 0.1
[B component]
Mizu eggplant juice of Production Example 2 5.0
Sorbitol 3.0
1,3-butylene glycol 5.0
Triethanolamine 1.5
Methylparaben 0.1
Purified water Amount of 100 parts [component C]
Titanium oxide 8.0
Talc 2.0
Kaolin 5.0
Bentonite 1.0
Coloring pigment appropriate amount [component D]
Fragrance 0.3
Component C was mixed and pulverized with a pulverizer. The component B was mixed, and the pulverized component C was added thereto and uniformly dispersed in a colloid mill. The components A and B and C dispersed uniformly were each heated to 80 ° C., and then the components A were added to the components B and C while stirring, and further homogenized with Hiscotron (5000 rpm) for 2 minutes. After cooling this to 50 degreeC, D component was added and stirred and mixed, and also it cooled to 30 degrees C or less, stirring, and obtained the cream foundation.
実施例21.ヘアートニック
[A成分] 部
エタノール 60.0
l−メントール 0.5
香料 0.1
メチルパラベン 0.1
[B成分]
グリセリン 2.0
1,3−ブチレングリコール 2.0
製造例5の水ナス果実抽出液 10.0
精製水 全量が100部となる量
上記のA成分とB成分をそれぞれ常温で溶解した後、A成分にB成分を攪拌しながら加え溶解させてヘアートニックを得た。
Example 21. Hair artic [component A] part ethanol 60.0
l-Menthol 0.5
Fragrance 0.1
Methylparaben 0.1
[B component]
Glycerin 2.0
1,3-butylene glycol 2.0
Juice eggplant fruit extract of Production Example 5 10.0
Purified water An amount that makes the total amount 100 parts The above A component and B component were each dissolved at room temperature, and then the B component was added to the A component with stirring and dissolved to obtain a hair artic.
実施例22.ヘアートリートメント
[成分] 部
塩化ステアリルトリメチルアンモニウム 6.0
ポリビニルピロリドン 4.0
グリセリン 1.0
エチルパラベン 0.1
製造例3の水ナス果実抽出液 5.0
精製水 全量が100部となる量
上記の成分を80℃に加温した後混合攪拌してヘアートリートメントを得た。
本品はヘアーパックとしても好適なものであった。
Example 22. Hair treatment [ingredient] part stearyltrimethylammonium chloride 6.0
Polyvinylpyrrolidone 4.0
Glycerin 1.0
Ethylparaben 0.1
Water eggplant fruit extract of Production Example 3 5.0
Purified water in a total amount of 100 parts The above ingredients were heated to 80 ° C and then mixed and stirred to obtain a hair treatment.
This product was also suitable as a hair pack.
実施例23.ヘアーシャンプー
[A成分] 部
N−ヤシ油脂肪酸メチルタウリンナトリウム 10.0
ポリオキシエチレン(3)アルキルエーテル硫酸ナトリウム 20.0
ラウリルジメチルアミノ酢酸ベタイン 10.0
ヤシ油脂肪酸ジエタノールアミド 4.0
メチルパラベン 0.1
[B成分]
クエン酸 0.1
製造例4の水ナス果実抽出液 5.0
1,3−ブチレングリコール 2.0
精製水 全量が100部となる量
A成分及びB成分をそれぞれ80℃に加温して均一に溶解した後、A成分にB成分を加え、攪拌を続けて室温まで冷却してヘアーシャンプーを得た。
Example 23. Hair shampoo [component A] part N-coconut oil fatty acid methyl taurine sodium 10.0
Polyoxyethylene (3) sodium alkyl ether sulfate 20.0
Lauryldimethylaminoacetic acid betaine 10.0
Palm oil fatty acid diethanolamide 4.0
Methylparaben 0.1
[B component]
Citric acid 0.1
Mizu eggplant fruit extract of Production Example 4 5.0
1,3-butylene glycol 2.0
Purified water Amount to be 100 parts A component and B component are each heated to 80 ° C and dissolved uniformly, then B component is added to A component, and stirring is continued to cool to room temperature to obtain a hair shampoo It was.
実施例24.ヘアーリンス
[A成分] 部
ポリオキシエチレン(10)硬化ヒマシ油 1.0
塩化ジステアリルジメチルアンモニウム 1.5
塩化ステアリルトリメチルアンモニウム 2.0
2−エチルヘキサン酸グリセリル 1.0
セタノール 3.2
ステアリルアルコール 1.0
メチルパラベン 0.1
[B成分]
製造例1の水ナス搾汁液 5.0
1,3−ブチレングリコール 5.0
精製水 全量が100部となる量
A成分及びB成分をそれぞれ80℃に加温して均一に溶解した後、A成分にB成分を加え、攪拌を続けて室温まで冷却してヘアーリンスを得た。
Example 24. Hair rinse [component A] Part Polyoxyethylene (10) hydrogenated castor oil 1.0
Distearyldimethylammonium chloride 1.5
Stearyltrimethylammonium chloride 2.0
Glyceryl 2-ethylhexanoate 1.0
Cetanol 3.2
Stearyl alcohol 1.0
Methylparaben 0.1
[B component]
Water eggplant juice from Production Example 1 5.0
1,3-butylene glycol 5.0
Purified water Amount to be 100 parts A component and B component are each heated to 80 ° C and dissolved uniformly, then B component is added to A component and stirring is continued to cool to room temperature to obtain hair rinse It was.
実施例25.ボディシャンプー
[A成分] 部
N−ラウロイルメチルアラニンナトリウム 25.0
ヤシ油脂肪酸カリウム液(40%) 26.0
ヤシ油脂肪酸ジエタノールアミド 3.0
メチルパラベン 0.1
[B成分]
製造例2の水ナス搾汁液 10.0
1,3−ブチレングリコール 2.0
精製水 全量が100部となる量
A成分及びB成分をそれぞれ80℃に加温して均一に溶解した後、A成分にB成分を加え、攪拌を続けて室温まで冷却してボディシャンプーを得た。
Example 25. Body shampoo [component A] part N-lauroylmethylalanine sodium 25.0
Palm oil fatty acid potassium liquid (40%) 26.0
Palm oil fatty acid diethanolamide 3.0
Methylparaben 0.1
[B component]
Juice eggplant juice of Production Example 2 10.0
1,3-butylene glycol 2.0
Purified water Amount to be 100 parts A component and B component are each heated to 80 ° C and dissolved uniformly, then B component is added to A component and stirring is continued to cool to room temperature to obtain a body shampoo It was.
実施例26.石けん
[A成分] 部
硬化ヒマシ油 26.0
ヤシ油 10.0
オリーブ油 4.0
[B成分]
水酸化ナトリウム 6.0
砂糖 10.0
グリセリン 5.0
製造例7の水ナス搾汁液粉末 0.5
精製水 全量が100部となる量
[C成分]
エタノール 20.0
香料 適量
A成分及びB成分をそれぞれ80℃に加温して均一に溶解した後、A成分にB成分を加えてケン化した。これを攪拌しながら50℃まで冷却し、C成分を加えた。これを型に流し込み冷却した後、室温下で数日間乾燥させ、充分に乾燥したものを型から取りだして石けんを得た。
Example 26. Soap [component A] part hardened castor oil 26.0
Coconut oil 10.0
Olive oil 4.0
[B component]
Sodium hydroxide 6.0
Sugar 10.0
Glycerin 5.0
Mizu eggplant juice liquid powder of Production Example 7 0.5
Purified water Amount of 100 parts [component C]
Ethanol 20.0
Perfume Appropriate A component and B component were each heated to 80 ° C. and dissolved uniformly, and then B component was added to A component to saponify. This was cooled to 50 ° C. with stirring, and component C was added. This was poured into a mold and cooled, and then dried at room temperature for several days. A sufficiently dried product was taken out from the mold to obtain soap.
比較実施例1.クリーム
実施例1のB成分中、製造例1の水ナス搾汁液に代えて比較製造例1の長ナス搾汁液を用いるほかは実施例1と同様にしてクリームを得た。
Comparative Example 1 Cream A cream was obtained in the same manner as in Example 1 except that the long eggplant juice of Comparative Production Example 1 was used instead of the water eggplant juice of Production Example 1 in the component B of Example 1.
比較実施例2.クリーム
実施例1のB成分中、製造例1の水ナス搾汁液に代えて比較製造例2の米ナス搾汁液を用いるほかは実施例1と同様にしてクリームを得た。
Comparative Example 2 Cream A cream was obtained in the same manner as in Example 1 except that the rice eggplant juice of Comparative Production Example 2 was used instead of the water eggplant juice of Production Example 1 in the component B of Example 1.
試験例1.表皮細胞におけるコラーゲン産生促進試験
製造例1〜3で得られた水ナス搾汁液及び水ナス果実抽出液と比較製造例1及び2で得られた長ナス及び米ナス搾汁液を試料として用い、それらを各々精製水で希釈して固形分が1%となるように調整した溶液について、表皮細胞におけるコラーゲン産生促進作用を調べた。
Test Example 1 Collagen production promotion test in epidermal cells Using water eggplant juice and water eggplant fruit extract obtained in Production Examples 1-3 and long eggplant and rice eggplant juice obtained in Comparative Production Examples 1 and 2 as samples, Each of these solutions was diluted with purified water to adjust the solid content to 1%, and the collagen production promoting action in epidermal cells was examined.
[試験方法]
ヒト皮膚由来表皮細胞PHK16−0b(Lot.060325)を、MCDB153(シグマ社製)及びエピダーセルHKGS(クラボウ社製)を入れた96穴マイクロプレートに1×104個/穴播種し、37℃で1日間プレ培養した後、培地に試料溶液を1.0又は5.0%の濃度(溶液濃度として)になるように添加して、37℃でさらに5日間培養した。
次に培養液を除去し、0.04%ファストグリーン、0,05%シリウスレッド溶液を添加し、細胞内のコラーゲン及び非コラーゲンを染色した後、充分に洗浄した。次に0.1%NaOH含有メタノールで抽出し、コラーゲン量は波長540nmで測定した。また、試料無添加の場合(コントロール)について同様の試験を行った。
結果は、試料無添加(コントロール)の波長540nmに於ける吸光度を100としたときの各試料添加時の吸光度の相対値(コラーゲン産生率)を以て示した。
[Test method]
Human skin-derived epidermal cells PHK16-0b (Lot. 060325) were seeded at 1 × 10 4 cells / hole in a 96-well microplate containing MCDB153 (manufactured by Sigma) and epidercel HKGS (manufactured by Kurabo Industries) at 37 ° C. After pre-culturing for 1 day, the sample solution was added to the medium so as to have a concentration of 1.0 or 5.0% (as a solution concentration), and further cultured at 37 ° C. for 5 days.
Next, the culture solution was removed, 0.04% fast green, 0.05% sirius red solution was added, and intracellular collagen and non-collagen were stained, and then washed thoroughly. Next, extraction was performed with methanol containing 0.1% NaOH, and the amount of collagen was measured at a wavelength of 540 nm. Moreover, the same test was done when no sample was added (control).
The results are shown as the relative values (collagen production rate) of the absorbance when each sample was added, assuming that the absorbance at a wavelength of 540 nm when no sample was added (control) was 100.
[結果]
結果を図1に示す。図1に於いて、A〜Kの符号は以下のものを意味する
A:コントロール
B:製造例1の搾汁液の1%添加区
C:製造例1の搾汁液の5%添加区
D:製造例2の搾汁液の1%添加区
E:製造例2の搾汁液の5%添加区
F:製造例3の搾汁液の1%添加区
G:製造例3の搾汁液の5%添加区
H:比較製造例1の搾汁液の1%添加区
I:比較製造例1の搾汁液の5%添加区
J:比較製造例2の搾汁液の1%添加区
K:比較製造例2の搾汁液の5%添加区
[result]
The results are shown in FIG. In FIG. 1, the symbols A to K mean the following: A: Control B: 1% addition of the juice of Production Example 1 C: Add 5% of the juice of Production 1 D: Production 1% addition zone E of the juice of Example 2: 5% addition zone of the juice of Production Example 2 F: 1% addition zone of the juice of Production Example 3 G: 5% addition zone H of the juice of Production Example 3 : 1% added section of the squeezed liquid of Comparative Production Example 1 I: added 5% of the squeezed liquid of Comparative Production Example 1 J: 1% added section of the squeezed liquid of Comparative Production Example 2 K: squeezed liquid of the Comparative Production Example 2 5% added zone
図1に示すように、本発明の水ナスの搾汁液(製造例1、2)或いは水ナス果実抽出液(製造例3)には、ヒト皮膚由来表皮細胞におけるコラーゲン産生を顕著に促進する効果が確認された。これに対して、長ナスの搾汁液(比較製造例1)及び米ナスの搾汁液(比較製造例2)については、5%の添加で若干のコラーゲン産生促進作用が認められるが、本発明試料に遠く及ばないものであった。 As shown in FIG. 1, the water eggplant juice (Production Examples 1 and 2) or the water eggplant fruit extract (Production Example 3) of the present invention has an effect of significantly promoting collagen production in human skin-derived epidermal cells. Was confirmed. On the other hand, for the eggplant squeezed juice (Comparative Production Example 1) and rice eggplant squeezed juice (Comparative Production Example 2), a slight collagen production promoting effect is observed with the addition of 5%. It was not far away.
試験例2.線維芽細胞におけるコラーゲン産生促進試験
試験例1と同様の試料について、真皮線維芽細胞におけるコラーゲン産生促進作用を調べた。
[試験方法]
ヒト皮膚真皮由来線維芽細胞NB1RGB(Lot.051203(12))を、0.5%NCS含有最小必須培地を入れた96穴マイクロプレートに1×104個/穴播種し、37℃で1日間プレ培養した後、培地に試料溶液を1.0又は5.0%の濃度(溶液濃度として)になるように添加して、37℃でさらに5日間培養した。
次に培養液を除去し、0.04%ファストグリーン、0,05%シリウスレッド溶液を添加し、細胞内のコラーゲン及び非コラーゲンを染色した後、充分に洗浄した。次に0.1%NaOH含有メタノールで抽出し、コラーゲン量は波長540nmで測定した。また、試料無添加の場合(コントロール)と、さらに試験系が正常に機能しているかを確認するための試験として、試料溶液の代わりにL−アスコルビン酸−2−リン酸エステルマグネシウム(APM)を2mM添加した場合について、それぞれ同様の試験を行った。
結果は、試料無添加(コントロール)の波長540nmに於ける吸光度を100としたときの各試料添加時の吸光度の相対値(コラーゲン産生率)を以て示した。
Test Example 2 Collagen production promotion test in fibroblasts For the same sample as in Test Example 1, the collagen production promotion effect in dermal fibroblasts was examined.
[Test method]
Human skin dermis-derived fibroblasts NB1RGB (Lot. 051203 (12)) were seeded at 1 × 10 4 cells / hole in a 96-well microplate containing 0.5% NCS-containing minimum essential medium, and at 37 ° C. for 1 day. After pre-culture, the sample solution was added to the medium so as to have a concentration of 1.0 or 5.0% (as a solution concentration), and further cultured at 37 ° C. for 5 days.
Next, the culture solution was removed, 0.04% fast green, 0.05% sirius red solution was added, and intracellular collagen and non-collagen were stained, and then washed thoroughly. Next, extraction was performed with methanol containing 0.1% NaOH, and the amount of collagen was measured at a wavelength of 540 nm. In addition, L-ascorbic acid-2-phosphate magnesium (APM) was used instead of the sample solution as a test for confirming whether the test system was functioning normally when the sample was not added (control). The same test was performed for each case where 2 mM was added.
The results are shown as the relative values (collagen production rate) of the absorbance when each sample was added, assuming that the absorbance at a wavelength of 540 nm when no sample was added (control) was 100.
[結果]
結果を図2に示す。図2に於いて、L〜Vの符号は以下のものを意味する
L:コントロール
M:製造例1の搾汁液の1%添加区
N:製造例1の搾汁液の5%添加区
O:製造例2の搾汁液の1%添加区
P:製造例2の搾汁液の5%添加区
Q:製造例3の搾汁液の1%添加区
R:製造例3の搾汁液の5%添加区
S:比較製造例1の搾汁液の1%添加区
T:比較製造例1の搾汁液の5%添加区
U:比較製造例2の搾汁液の1%添加区
V:比較製造例2の搾汁液の5%添加区
[result]
The results are shown in FIG. In FIG. 2, the symbols L to V mean the following: L: Control M: 1% addition zone of the juice of Production Example 1 N: 5% addition zone of the juice of Production Example 1 O: Production 1% addition zone P of the juice of Example 2 5% addition zone of the juice of Production Example 2 Q: 1% addition zone of the juice of Production Example 3 R: 5% addition zone S of the juice of Production Example 3 : 1% added section of the juice of Comparative Production Example 1 T: 5% added section of the juice of Comparative Production Example 1 U: 1% added section of the juice of Comparative Production Example 2 V: Juice of the Comparative Production Example 2 5% added zone
図2に示すように、本発明の水ナス搾汁液(製造例1,2)および水ナス果実抽出液(製造例3)には、正常ヒト由来線維芽細胞におけるコラーゲン産生を顕著に促進する効果が確認された。これに対して、長ナスの搾汁液(比較製造例1)及び米ナスの搾汁液(比較製造例2)の示すコラーゲン産生促進作用は本発明試料に遠く及ばないものであった。 As shown in FIG. 2, the water eggplant juice (Production Examples 1 and 2) and the water eggplant fruit extract (Production Example 3) of the present invention have the effect of significantly promoting collagen production in normal human-derived fibroblasts. Was confirmed. On the other hand, the collagen production promoting action exhibited by the squeezed eggplant juice (Comparative Production Example 1) and the rice eggplant juice (Comparative Production Example 2) was far from the sample of the present invention.
試験例3.皮膚刺激性
[試料]
(1)製造例1の水ナス搾汁液を日局親水ワセリンに5%の濃度となるように練合したもの(本発明試料1)
(2)製造例2の水ナス搾汁液を日局親水ワセリンに5%の濃度となるように練合したもの(本発明試料2)
(3)製造例3の水ナス果実抽出液を日局親水ワセリンに5%の濃度となるように練合したもの(本発明試料3)
(4)製造例4の水ナス果実抽出液を日局親水ワセリンに5%の濃度となるように練合したもの(本発明試料4)
(5)日局親水ワセリン(対照)
Test Example 3 Skin irritation [sample]
(1) Kneaded eggplant juice from Production Example 1 kneaded with JP Vaseous Petroleum to a concentration of 5% (Invention Sample 1)
(2) Kneaded eggplant juice from Production Example 2 kneaded with JP Petroleum Vaseline to a concentration of 5% (Invention Sample 2)
(3) Water eggplant fruit extract of Production Example 3 kneaded to JP Hydrophilic Vaseline to a concentration of 5% (Invention Sample 3)
(4) Kneaded eggplant fruit extract of Production Example 4 kneaded in JP Hydrophilic Petrolatum to a concentration of 5% (Invention Sample 4)
(5) JP Hydrophilic Petrolatum (control)
[試験方法]
年齢20〜50歳の成人男子5名を被験者とし、各々の上腕部内側をエタノールで拭って皮脂を除去し、該部位に、フィンチャンバーのアルミ板に本発明試料1〜4及び対照の日局親水ワセリンをそれぞれ0.2g宛塗布したものを貼付した。24時間後にフィンチャンバーを除去し、皮膚刺激の程度をつぎに述べる方法並びに基準により判定した。
[判定]
パッチ除去後1時間後、24時間後及び48時間後に、貼付部位の紅斑及び浮腫の状況を、以下の「ドレイズ法による皮膚刺激性判定基準」に基づき目視判定し、被験者5名の平均値を求めた。
(紅斑)
スコア 皮膚の状態
0 : 紅斑なし
1 : 極軽度の紅斑
2 : 明らかな紅斑
3 : 中程度から強い紅斑
4 : 深紅色の強い紅斑に軽い痂皮形成
(浮腫)
スコア 皮膚の状態
0 : 浮腫なし
1 : 極軽度の浮腫
2 : 明らかな浮腫(周囲と明らかに区別可能)
3 : 中程度の浮腫(1mm以上の盛り上がり)
4 : 強い浮腫(さらに周囲にも広がり)
[Test method]
Five adult males aged 20 to 50 years were used as subjects, and the inner side of each upper arm was wiped with ethanol to remove sebum, and the samples 1 to 4 of the present invention and the control bureau were placed on the aluminum plate of the fin chamber. What applied each 0.2g of hydrophilic petrolatum was stuck. After 24 hours, the fin chamber was removed, and the degree of skin irritation was determined by the method and criteria described below.
[Judgment]
After 1 hour, 24 hours and 48 hours after removing the patch, the state of erythema and edema at the applied site was visually determined based on the following “skin irritation criteria by dreze method”, and the average value of 5 subjects Asked.
(Erythema)
Score Skin condition 0: No erythema 1: Extremely mild erythema 2: Clear erythema 3: Moderate to strong erythema 4: Light crust formation in strong crimson erythema (edema)
Score Skin condition 0: No edema 1: Extremely mild edema 2: Clear edema (clearly distinguishable from surroundings)
3: Moderate edema (swelling of 1 mm or more)
4: Strong edema (further spread around)
結果を表1に示す。
表1の結果から明らかな通り、本発明の水ナス搾汁液及びその水ナス果実抽出液は、皮膚刺激がなく安全性に極めてすぐれている。 As is apparent from the results in Table 1, the water eggplant juice and the water eggplant fruit extract of the present invention have no skin irritation and are extremely safe.
試験例1.モニターテスト
実施例1及び2のクリームと比較実施例1及び2のクリームについて、モニターテストにより皮膚に対する効果を調べた。
[試験方法]
無作為に抽出した年齢18〜50歳の女性40名を被験者として20名ずつ2つのグループ(A、B)に分け、各グループに、実施例1と比較実施例1のクリーム又は実施例2と比較実施例2のクリームの2種の組み合わせのいずれかを割り振り、それぞれ左右の頬部に、実施例又は比較実施例のクリームを1日2回(朝、晩)、1ヵ月間塗布してもらった後、小ジワに対する改善効果及び肌のはり、艶に対する改善効果を、以下の評価基準に基づいて評価した。
Test Example 1 Monitor Test The effects of the creams of Examples 1 and 2 and Comparative Example 1 and 2 on the skin were examined by a monitor test.
[Test method]
Randomly extracted 40 women aged 18-50 were divided into two groups (A, B) of 20 subjects as subjects, and each group was divided into Example 1 and Comparative Example 1 cream or Example 2. One of the two combinations of the cream of Comparative Example 2 was allocated, and the cream of the Example or Comparative Example was applied to the left and right cheeks twice a day (morning and evening) for one month. Then, the improvement effect with respect to fine wrinkles and the improvement effect with respect to skin tension and gloss were evaluated based on the following evaluation criteria.
[評価基準]
(小ジワに対する改善効果)
A:殆ど目立たなくなった
B:かなり目立たなくなった
C:わずかに目立たなくなった
D:変わらない
E:かえって増えた
(肌のはり、艶に対する改善効果)
A:明らかに改善された
B:かなり改善された
C:僅かに改善された
D:変わらない
E:かえって悪くなった
[Evaluation criteria]
(Improvement effect on small wrinkles)
A: Almost inconspicuous B: Almost inconspicuous C: Slightly inconspicuous D: Unchanged E: On the contrary (Improvement effect on skin elasticity and gloss)
A: Clearly improved B: Much improved C: Slightly improved D: No change E: On the contrary
[結果]
結果を表2に示す。なお、表中のA〜Eの各評価欄の数字は、被験者20名中当該評価を行った被験者の数を示す。
The results are shown in Table 2. In addition, the number of each evaluation column of AE in a table | surface shows the number of the test subjects who performed the said evaluation in 20 test subjects.
表2に示す通り、水ナスの搾汁液を活性成分として配合してなる本発明のクリームは、皮膚の老化或いは不健全化の典型的な症状であるシワ、たるみ等に対してすぐれた改善作用を示す。
これに対して、長ナス又は米ナスの搾汁液を配合した比較実施例のクリームでは、ほとんど改善効果が見られず、明らかに有効性に違いがある結果となった。
As shown in Table 2, the cream of the present invention, which is prepared by blending squeezed water eggplant juice as an active ingredient, is excellent in improving wrinkles and sagging, which are typical symptoms of skin aging or unhealing. Indicates.
On the other hand, in the cream of the comparative example which mix | blended the juice of long eggplant or rice eggplant, the improvement effect was hardly seen but it resulted in a difference in effectiveness clearly.
A:試験例1に於けるコントロール
B:試験例1に於ける製造例1の搾汁液の1%添加区
C:試験例1に於ける製造例1の搾汁液の5%添加区
D:試験例1に於ける製造例2の搾汁液の1%添加区
E:試験例1に於ける製造例2の搾汁液の5%添加区
F:試験例1に於ける試験例1に於ける製造例3の搾汁液の1%添加区
G:試験例1に於ける製造例3の搾汁液の5%添加区
H:試験例1に於ける比較製造例1の搾汁液の1%添加区
I:試験例1に於ける比較製造例1の搾汁液の5%添加区
J:試験例1に於ける比較製造例2の搾汁液の1%添加区
K:試験例1に於ける比較製造例2の搾汁液の5%添加区
L:試験例2に於けるコントロール
M:試験例2に於ける製造例1の搾汁液の1%添加区
N:試験例2に於ける製造例1の搾汁液の5%添加区
O:試験例2に於ける試験例2に於ける製造例2の搾汁液の1%添加区
P:試験例2に於ける製造例2の搾汁液の5%添加区
Q:試験例2に於ける製造例3の搾汁液の1%添加区
R:試験例2に於ける製造例3の搾汁液の5%添加区
S:試験例2に於ける比較製造例1の搾汁液の1%添加区
T:試験例2に於ける比較製造例1の搾汁液の5%添加区
U:試験例2に於ける比較製造例2の搾汁液の1%添加区
V:試験例2に於ける比較製造例2の搾汁液の5%添加区
A: Control B in Test Example 1 B: 1% addition of squeezed liquid of Production Example 1 in Test Example 1 C: 5% addition of squeezed liquid of Production Example 1 in Test Example 1 D: Test 1% of the squeezed liquid of Production Example 2 in Example 1 E: 5% of the squeezed liquid of Production Example 2 in Test Example 1 F: Production of Test Example 1 in Test Example 1 1% addition section G of the juice of Example 3: 5% addition section of the juice of Production Example 3 in Test Example 1 H: 1% addition section I of the juice of Comparative Production Example 1 in Test Example 1 : 5% addition zone of juice of Comparative Production Example 1 in Test Example 1 J: 1% addition zone of juice of Comparative Production Example 2 in Test Example K: Comparative Production Example in Test Example 1 5% added section of the squeezed liquid of No. 2: control M in Test Example 2 M: added 1% of the squeezed liquid of Production Example 1 in Test Example 2 N: squeezed of Production Example 1 in Test Example 2 5% of juice Ka: O: 1% of the juice of the squeezed liquid of Production Example 2 in Test Example 2: P: 5% of the squeezed liquid of Production Example 2 of Test Example 2: Q: Test Example 2: 1% of the squeezed liquid of Production Example 3 in Production Example R: 5% of the squeezed liquid of Production Example 3 in Experimental Example 2 S: The squeezed liquid of Comparative Production Example 1 in Experimental Example 2 1% addition zone T: 5% addition zone of squeezed liquid of Comparative Production Example 1 in Test Example 2 U: 1% addition zone of squeezed liquid of Comparative Production Example 2 in Test Example 2 V: In Test Example 2 5% of the juice of Comparative Production Example 2
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JP6498867B2 (en) * | 2014-04-04 | 2019-04-10 | 共栄化学工業株式会社 | Moisturizing composition |
JP7248875B2 (en) * | 2017-08-10 | 2023-03-30 | 共栄化学工業株式会社 | Skin topical composition |
JP2019202966A (en) * | 2018-05-24 | 2019-11-28 | ピアス株式会社 | Differentiation inducer for bone marrow stem cells, epidermis improving agent, skin external preparation, and epidermis improving method |
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