JP4733385B2 - 男性および女性の***不能の処置に有用な配合剤 - Google Patents
男性および女性の***不能の処置に有用な配合剤 Download PDFInfo
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- JP4733385B2 JP4733385B2 JP2004503027A JP2004503027A JP4733385B2 JP 4733385 B2 JP4733385 B2 JP 4733385B2 JP 2004503027 A JP2004503027 A JP 2004503027A JP 2004503027 A JP2004503027 A JP 2004503027A JP 4733385 B2 JP4733385 B2 JP 4733385B2
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- arginine
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- 239000008213 purified water Substances 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000035946 sexual desire Effects 0.000 description 1
- 229960003310 sildenafil Drugs 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229940047183 tribulus Drugs 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Reproductive Health (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Description
各々1.5〜3.5:1〜2:0.1〜0.4の重量比のトリブルステレストリス(Tribulus terrestris)、エピメジウムコリアニウム(Epimedium koreanum)、シナモンカシア(Cinnamon cassia)の抽出物、ならびに場合により
アルギニンまたは生理学的に等価なそのエステル、塩もしくは前駆体および適切な担体または賦形剤、
を含む医薬組成物に関する。
各700mg被覆錠剤は、以下を含有する。
トリブルステレストリス(Tribulus terrestris) 250.00mg
エピメジウムコリアニウム(Epimedium koreanum) 150.00mg
シナモンカシア(Cinnamon cassia) 20.00mg
L−アルギニン 100.00mg
大豆多糖類 55.00mg
二酸化ケイ素 14.00mg
珪化微結晶性セルロース 92.00mg
ステアリン酸マグネシウム 4.00mg
ヒドロキシプロピルメチルセルロース 6.40mg
タルク 5.20mg
二酸化チタン 2.00mg
グリセリン 0.12mg
ポリソルベート80 0.80mg
キノリン 0.43mg
インジゴチン 0.05mg
各340mgカプセルは、以下を含有する。
トリブルステレストリス(Tribulus terrestris) 125.00mg
エピメジウムコリアニウム(Epimedium koreanum) 75.00mg
シナモンカシア(Cinnamon cassia) 10.00mg
L−アルギニン 50.00mg
大豆多糖類 25.00mg
二酸化ケイ素 7.00mg
珪化微結晶性セルロース 45.00mg
ステアリン酸マグネシウム 1.50mg
タルク 1.50mg
各700mg軟質ゼラチンカプセルは、以下を含有する。
トリブルステレストリス(Tribulus terrestris) 125.00mg
エピメジウムコリアニウム(Epimedium koreanum) 75.00mg
シナモンカシア(Cinnamon cassia) 10.00mg
L−アルギニン 50.00mg
大豆レシチン 20.00mg
中鎖トリグリセリド 100.00mg
ポリソルベート80 10.00mg
大豆油 300.00mg
コロイド性二酸化ケイ素 10.00mg
各10mlバイアルは、以下を含有する。
トリブルステレストリス(Tribulus terrestris) 250.00mg
エピメジウムコリアニウム(Epimedium koreanum) 150.00mg
シナモンカシア(Cinnamon cassia) 20.00mg
塩酸L−アルギニン 100.00mg
グリセリン 3000.00mg
ポリソルベート20 800.00mg
プロピレングリコール 1000.00mg
アセスルファムK 175.00mg
サッカリンナトリウム 40.00mg
ネオヘスペリジンDC 2.50mg
着香剤 300.00mg
ソルビン酸カリウム 11.70mg
メチルパラベン 8.30mg
精製水 全量で10.00ml
各5000mg小袋は、以下を含有する。
トリブルステレストリス(Tribulus terrestris) 250.00mg
エピメジウムコリアニウム(Epimedium koreanum) 150.00mg
シナモンカシア(Cinnamon cassia) 20.00mg
塩酸L−アルギニン 100.00mg
ポリソルベート20 500.00mg
アセスルファムK 175.00mg
サッカリンナトリウム 40.00mg
ネオヘスペリジンDC 2.50mg
着香剤 300.00mg
イヌリン 1000.00mg
マンニトール 2412.50mg
Claims (4)
- 各々2.5:1.5:0.2の重量比の、ディオシンとして表現されるおよそ40%のサポニンを含有するトリブルステレストリス(Tribulus terrestris)、イカリンとして表現されるフラボノイド含有量がおよそ60%であるエピメジウムコリアナム(Epimedium koreanum)、桂皮アルデヒド含量がおよそ70%であるシナモンカシア(Cinnamon cassia)の抽出物を含む、男性および女性の性的機能不全の処置のための医薬組成物。
- 各々2.5:1.5:0.2の重量比の、ディオシンとして表現されるおよそ40%のサポニンを含有するトリブルステレストリス(Tribulus terrestris)、イカリンとして表現されるフラボノイド含有量がおよそ60%であるエピメジウムコリアナム(Epimedium koreanum)、桂皮アルデヒド含量がおよそ70%であるシナモンカシア(Cinnamon cassia)の抽出物、ならびに
アルギニンまたは生理学的に等価なそのエステル、塩および適切な担体または賦形剤を含む、男性および女性の性的機能不全の処置のための医薬組成物。 - 各々2.5:1.5:0.2:0.5〜1.5の重量比の、ディオシンとして表現されるおよそ40%のサポニンを含有するトリブルステレストリス(Tribulus terrestris)、イカリンとして表現されるフラボノイド含有量がおよそ60%であるエピメジウムコリアナム(Epimedium koreanum)、桂皮アルデヒド含量がおよそ70%であるシナモンカシア(Cinnamon cassia)の抽出物、およびL−アルギニンまたは塩酸L−アルギニンを含有する、請求項1または2のいずれか1項に記載の男性および女性の性的機能不全の処置のための医薬組成物。
- ディオシンとして表現されるおよそ40%のサポニンを含有するトリブルステレストリス(Tribulus terrestris)、イカリンとして表現されるフラボノイド含有量がおよそ60%であるエピメジウムコリアナム(Epimedium koreanum)、桂皮アルデヒド含量がおよそ70%であるシナモンカシア(Cinnamon cassia)の抽出物、およびL−アルギニンまたは塩酸L−アルギニンの重量比が2.5:1.5:0.2:1である、請求項3に記載の男性および女性の性的機能不全の処置のための医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2002MI000994A ITMI20020994A1 (it) | 2002-05-10 | 2002-05-10 | Formulazioni utili nel trattamento dell'impotenza maschile e femminile |
ITMI2002A000994 | 2002-05-10 | ||
PCT/EP2003/004611 WO2003094944A1 (en) | 2002-05-10 | 2003-05-02 | Formulations useful in the treatment of male and female impotence |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010269123A Division JP2011079853A (ja) | 2002-05-10 | 2010-12-02 | 男性および女性の***不能の処置に有用な配合剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005530769A JP2005530769A (ja) | 2005-10-13 |
JP4733385B2 true JP4733385B2 (ja) | 2011-07-27 |
Family
ID=11449870
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004503027A Expired - Fee Related JP4733385B2 (ja) | 2002-05-10 | 2003-05-02 | 男性および女性の***不能の処置に有用な配合剤 |
JP2010269123A Pending JP2011079853A (ja) | 2002-05-10 | 2010-12-02 | 男性および女性の***不能の処置に有用な配合剤 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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JP2010269123A Pending JP2011079853A (ja) | 2002-05-10 | 2010-12-02 | 男性および女性の***不能の処置に有用な配合剤 |
Country Status (20)
Country | Link |
---|---|
US (2) | US7361370B2 (ja) |
EP (2) | EP1505997B1 (ja) |
JP (2) | JP4733385B2 (ja) |
KR (1) | KR20040102219A (ja) |
CN (1) | CN100522178C (ja) |
AT (2) | ATE380024T1 (ja) |
AU (1) | AU2003232248B8 (ja) |
CA (1) | CA2485389A1 (ja) |
DE (2) | DE60303940T2 (ja) |
DK (2) | DK1652520T3 (ja) |
ES (2) | ES2297593T3 (ja) |
HK (1) | HK1076033A1 (ja) |
IL (2) | IL165122A (ja) |
IT (1) | ITMI20020994A1 (ja) |
NO (1) | NO332806B1 (ja) |
PL (2) | PL204549B1 (ja) |
PT (2) | PT1505997E (ja) |
RU (1) | RU2313358C2 (ja) |
SI (1) | SI1652520T1 (ja) |
WO (1) | WO2003094944A1 (ja) |
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KR100692174B1 (ko) * | 2005-03-25 | 2007-03-09 | 손병국 | 신장활성과 항피로, 강정, 강장, 성기능 개선용 건강기능식품 |
CN1989990B (zh) * | 2005-12-27 | 2010-09-01 | 郭凯 | 一种治疗***功能障碍的药物及其制备方法 |
EP2011496A1 (en) * | 2007-07-03 | 2009-01-07 | Indena S.P.A. | Combinations of vasoactive substances with estrogens and their use in the treatment of female sexual dysfunctions |
US20100178413A1 (en) * | 2008-12-17 | 2010-07-15 | Mark Gorris | Food-based Supplement Delivery System |
US9918489B2 (en) * | 2008-12-17 | 2018-03-20 | Mark Gorris | Food-based supplement delivery system |
US20110206788A1 (en) * | 2010-01-29 | 2011-08-25 | Chaudhary Latha | Novel herbal composition |
ITRM20100068A1 (it) * | 2010-02-19 | 2011-08-20 | Fabrizio Iacono | Integratore alimentare con componenti che stimolano la funzione sessuale nel maschio |
SI2477633T1 (sl) * | 2009-09-17 | 2013-11-29 | Tradapharma Sagl | Prehranski dodatek, ki stimulira moško spolno funkcijo |
IT1395768B1 (it) * | 2009-09-17 | 2012-10-19 | Iacono | Integratore alimentare con componenti che stimolano la funzione sessuale nel maschio |
ES2386859B1 (es) * | 2011-02-07 | 2013-03-22 | Eduardo Antonio Gómez De Diego | Composición natural para aumentar el vigor. |
RU2458537C1 (ru) * | 2011-03-14 | 2012-08-20 | Общество С Ограниченной Ответственностью "Парафарм" | Биологически активная добавка к пище для профилактики эректильной дисфункции у мужчин |
KR20130032419A (ko) * | 2011-09-23 | 2013-04-02 | 씨제이제일제당 (주) | 복합생약추출물을 포함하는 발기부전 예방 및 개선용 조성물 |
US9913870B2 (en) * | 2012-01-13 | 2018-03-13 | Dharma Biomedical, Llc | Method for stimulating AMP-activated protein kinase |
RU2496491C1 (ru) | 2012-08-20 | 2013-10-27 | Общество С Ограниченной Ответственностью "Парафарм" | Способ восстановления полового влечения (либидо) у мужчин путем применения биологически активной добавки к пище для восстановления полового влечения (либидо) у мужчин |
TW201420745A (zh) * | 2012-11-26 | 2014-06-01 | Tian-De Li | 擴充男性海綿體的複方精油 |
CN103250851A (zh) * | 2013-02-24 | 2013-08-21 | 沈根林 | 一种中药补肾蜜饯肠 |
CN103250852A (zh) * | 2013-02-24 | 2013-08-21 | 沈根林 | 一种中药补肾蜜饯肠 |
CN104000198B (zh) * | 2014-06-13 | 2016-03-23 | 上海赫尔伯生物科技有限公司 | 一种具有补肾填精、益神兴阳作用的复方胶囊及其制备方法 |
CN104352540B (zh) * | 2014-10-20 | 2017-08-18 | 成都中医药大学 | 一种治疗冠心病心绞痛的亲水凝胶骨架型缓释片及其制备方法 |
WO2017010487A1 (ja) * | 2015-07-13 | 2017-01-19 | 協和発酵バイオ株式会社 | アルギニンを高含有する錠剤 |
CN106614589A (zh) * | 2016-11-13 | 2017-05-10 | 徐州得铸生物科技有限公司 | 一种含蒺藜皂甙的杀虫剂组合物 |
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-
2002
- 2002-05-10 IT IT2002MI000994A patent/ITMI20020994A1/it unknown
-
2003
- 2003-05-02 PT PT03749863T patent/PT1505997E/pt unknown
- 2003-05-02 ES ES05025314T patent/ES2297593T3/es not_active Expired - Lifetime
- 2003-05-02 RU RU2004133025/15A patent/RU2313358C2/ru not_active IP Right Cessation
- 2003-05-02 PL PL373096A patent/PL204549B1/pl unknown
- 2003-05-02 KR KR10-2004-7017938A patent/KR20040102219A/ko active Search and Examination
- 2003-05-02 DK DK05025314T patent/DK1652520T3/da active
- 2003-05-02 AT AT05025314T patent/ATE380024T1/de active
- 2003-05-02 US US10/513,819 patent/US7361370B2/en not_active Expired - Fee Related
- 2003-05-02 EP EP03749863A patent/EP1505997B1/en not_active Expired - Lifetime
- 2003-05-02 CN CNB038105292A patent/CN100522178C/zh not_active Expired - Fee Related
- 2003-05-02 SI SI200331079T patent/SI1652520T1/sl unknown
- 2003-05-02 JP JP2004503027A patent/JP4733385B2/ja not_active Expired - Fee Related
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1999001132A1 (fr) * | 1997-07-04 | 1999-01-14 | Real 2000 Limited | Medicament, contenant de la yohimbine et de l'arginine, destine a traiter les dysfonctions erectiles |
WO2000002573A1 (en) * | 1998-07-09 | 2000-01-20 | Duckett Melvin J | Natural composition and method for the treatment of sexual dysfunction |
US20020013280A1 (en) * | 2000-06-16 | 2002-01-31 | Zhongcheng Xin | Pharmaceutical composition for preventing and treating sexual dysfunction and vasculargenic disease comprising icariin |
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