JP4725082B2 - クロマトグラフ質量分析装置 - Google Patents
クロマトグラフ質量分析装置 Download PDFInfo
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- JP4725082B2 JP4725082B2 JP2004334150A JP2004334150A JP4725082B2 JP 4725082 B2 JP4725082 B2 JP 4725082B2 JP 2004334150 A JP2004334150 A JP 2004334150A JP 2004334150 A JP2004334150 A JP 2004334150A JP 4725082 B2 JP4725082 B2 JP 4725082B2
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- chromatogram
- mass spectrometer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/86—Signal analysis
- G01N30/8624—Detection of slopes or peaks; baseline correction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/80—Fraction collectors
- G01N30/82—Automatic means therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/86—Signal analysis
- G01N30/8624—Detection of slopes or peaks; baseline correction
- G01N30/8631—Peaks
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Description
異なる条件で同時に測定された複数のクロマトグラムについて、各時点のクロマトグラム信号を比較してそれらのうち最大値をその時点の信号値とする合成クロマトグラムを生成するクロマトグラム合成手段を備えることを特徴とする。
[実施例]
本発明の一実施例である液体クロマトグラフ質量分析装置(LC/MS)の要部の構成を図1に示す。本実施例の液体クロマトグラフ質量分析装置10は、質量分析によって得られたクロマトグラム信号をフラクションコレクタ20に出力するものであり、該フラクションコレクタ20では入力信号に基づいて試料の分取が行われる。
11…移動相容器
12…ポンプ
13…試料導入部
14…カラム
15…スプリッタ
16…質量分析部
16a…検出器
17…信号処理部
20…フラクションコレクタ
20a…制御部
Claims (1)
- クロマトグラフ部で時間的に分離された試料成分を質量分析部に導入して分析し、得られたクロマトグラムの信号を出力する機能を備えたクロマトグラフ質量分析装置において、
異なる条件で同時に測定された複数のクロマトグラムについて、各時点のクロマトグラム信号を比較してそれらのうち最大値をその時点の信号値とする合成クロマトグラムを生成するクロマトグラム合成手段を備えることを特徴とするクロマトグラフ質量分析装置。
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004334150A JP4725082B2 (ja) | 2004-11-18 | 2004-11-18 | クロマトグラフ質量分析装置 |
EP05024583.6A EP1659401B1 (en) | 2004-11-18 | 2005-11-10 | Chromatograph/mass spectrometer capable of producing a composite chromatogram |
US11/272,071 US7269994B2 (en) | 2004-11-18 | 2005-11-14 | Chromatograph/mass spectrometer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004334150A JP4725082B2 (ja) | 2004-11-18 | 2004-11-18 | クロマトグラフ質量分析装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006145319A JP2006145319A (ja) | 2006-06-08 |
JP4725082B2 true JP4725082B2 (ja) | 2011-07-13 |
Family
ID=35614657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004334150A Active JP4725082B2 (ja) | 2004-11-18 | 2004-11-18 | クロマトグラフ質量分析装置 |
Country Status (3)
Country | Link |
---|---|
US (1) | US7269994B2 (ja) |
EP (1) | EP1659401B1 (ja) |
JP (1) | JP4725082B2 (ja) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10319130B3 (de) * | 2003-04-28 | 2004-09-09 | Siemens Ag | Gaschromatograph mit nachgeordnetem Massenspektrometer und Verfahren zur gaschromatographisch-massenspektrometrischen Analyse eines Stoffgemischs |
EP1995593B1 (en) * | 2006-03-07 | 2015-05-06 | Shimadzu Corporation | Chromatograph mass spectrometer |
EP2232253A2 (en) * | 2007-12-05 | 2010-09-29 | All-Tech Associates Inc. | Methods and apparatus for analyzing samples and collecting sample fractions |
US8775098B2 (en) * | 2008-08-19 | 2014-07-08 | Shimadzu Corporation | Preparative liquid chromatograph system |
JP5083160B2 (ja) * | 2008-10-06 | 2012-11-28 | 株式会社島津製作所 | 四重極型質量分析装置 |
US8305582B2 (en) | 2009-09-01 | 2012-11-06 | Alltech Associates, Inc. | Methods and apparatus for analyzing samples and collecting sample fractions |
SG184783A1 (en) * | 2010-05-07 | 2012-11-29 | Alltech Associates Inc | Methods and apparatus for analyzing samples and collecting sample fractions |
JP5454462B2 (ja) * | 2010-12-22 | 2014-03-26 | 株式会社島津製作所 | クロマトグラフ質量分析装置 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03152850A (ja) * | 1989-11-07 | 1991-06-28 | Shimadzu Corp | ガスクロマトグラフ質量分析方法およびその装置 |
JPH04132153A (ja) * | 1990-09-21 | 1992-05-06 | Hitachi Ltd | 質量分析計 |
JPH04144051A (ja) * | 1990-10-03 | 1992-05-18 | Shimadzu Corp | ガスクロマトグラフ質量分析計のデータ処理装置 |
JPH05275053A (ja) * | 1992-03-26 | 1993-10-22 | Hitachi Ltd | Lc/api質量分析方法 |
JPH0835960A (ja) * | 1994-07-20 | 1996-02-06 | Shimadzu Corp | クロマトグラフ質量分析装置用データ処理装置 |
JPH1019849A (ja) * | 1996-06-28 | 1998-01-23 | Shimadzu Corp | クロマトグラフ質量分析用データ処理装置 |
JPH11295289A (ja) * | 1998-04-13 | 1999-10-29 | Hitachi Ltd | 液体クロマトグラフ三次元四重極質量分析法 |
JP2001099821A (ja) * | 1999-09-30 | 2001-04-13 | Shimadzu Corp | 液体クロマトグラフ質量分析装置 |
JP2004198123A (ja) * | 2002-12-16 | 2004-07-15 | Shimadzu Corp | 分取液体クロマトグラフ質量分析装置 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6438499B1 (en) * | 1998-09-10 | 2002-08-20 | Tosoh Corporation | Chromatogram analyzer |
AU2986400A (en) * | 1999-02-08 | 2000-08-25 | Admetric Biochem Inc. | Chromatographic system with pre-detector eluent switching |
US6329652B1 (en) * | 1999-07-28 | 2001-12-11 | Eastman Kodak Company | Method for comparison of similar samples in liquid chromatography/mass spectrometry |
US20040126277A1 (en) * | 2001-12-17 | 2004-07-01 | Yoshitake Yamamoto | Liquid chromatograph mass spectrometer |
-
2004
- 2004-11-18 JP JP2004334150A patent/JP4725082B2/ja active Active
-
2005
- 2005-11-10 EP EP05024583.6A patent/EP1659401B1/en not_active Expired - Fee Related
- 2005-11-14 US US11/272,071 patent/US7269994B2/en active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03152850A (ja) * | 1989-11-07 | 1991-06-28 | Shimadzu Corp | ガスクロマトグラフ質量分析方法およびその装置 |
JPH04132153A (ja) * | 1990-09-21 | 1992-05-06 | Hitachi Ltd | 質量分析計 |
JPH04144051A (ja) * | 1990-10-03 | 1992-05-18 | Shimadzu Corp | ガスクロマトグラフ質量分析計のデータ処理装置 |
JPH05275053A (ja) * | 1992-03-26 | 1993-10-22 | Hitachi Ltd | Lc/api質量分析方法 |
JPH0835960A (ja) * | 1994-07-20 | 1996-02-06 | Shimadzu Corp | クロマトグラフ質量分析装置用データ処理装置 |
JPH1019849A (ja) * | 1996-06-28 | 1998-01-23 | Shimadzu Corp | クロマトグラフ質量分析用データ処理装置 |
JPH11295289A (ja) * | 1998-04-13 | 1999-10-29 | Hitachi Ltd | 液体クロマトグラフ三次元四重極質量分析法 |
JP2001099821A (ja) * | 1999-09-30 | 2001-04-13 | Shimadzu Corp | 液体クロマトグラフ質量分析装置 |
JP2004198123A (ja) * | 2002-12-16 | 2004-07-15 | Shimadzu Corp | 分取液体クロマトグラフ質量分析装置 |
Also Published As
Publication number | Publication date |
---|---|
EP1659401A1 (en) | 2006-05-24 |
EP1659401B1 (en) | 2014-04-30 |
US7269994B2 (en) | 2007-09-18 |
JP2006145319A (ja) | 2006-06-08 |
US20060101898A1 (en) | 2006-05-18 |
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