JP4700011B2 - リンパ節の超音波画像の処理方法 - Google Patents
リンパ節の超音波画像の処理方法 Download PDFInfo
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- JP4700011B2 JP4700011B2 JP2006542522A JP2006542522A JP4700011B2 JP 4700011 B2 JP4700011 B2 JP 4700011B2 JP 2006542522 A JP2006542522 A JP 2006542522A JP 2006542522 A JP2006542522 A JP 2006542522A JP 4700011 B2 JP4700011 B2 JP 4700011B2
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- ultrasound
- lymph nodes
- image
- lymph node
- contrast agent
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Description
カラギーナン、デキストラン、ゼラチン、グアーガム、ローカストビーンガム、ビーガム、ケイ酸アルミニウムマグネシウム、二酸化ケイ素、ゼオライト、ペクチン、ポリエチレンオキシド、ポビドン、プロピレングリコールアルギネート、アルギン酸ナトリウム、トラガカント、キサンタンガム、α−d−グルコノラクトン、グリセロール及びマンニトールが挙げられる。
しかし、Fモードイメージングの重要な価値は生体内の解剖学的構造に対する流れを検出することにあるので、Fモード画像をスクリーン上のBモード画像と適切に位置合わせするのが一般に重要である。この技術は一つのパルスから得られた信号と次の信号との相関に依存し、しかも最初のパルスでマイクロバブルが破壊されることがあるので、運動とは関係しないF信号が発生する。こうした相関の喪失は様々な表示形式で示すことができるが、通常は色で表示される。
センチネルリンパ節のインビボ検出及び特性評価
メラノーマ腫瘍をもつ麻酔したSinclairブタを用いて、Sonazoid(商標)を用いたセンチネルリンパ節の検出及び特性決定を検討した。
テンプレート相関によるリンパ節画像の分析
Nelder−Meadの滑降シンプレックス法のような反復アルゴリズムを用いて、実施例1のテンプレートを実施例1の悪性リンパ節の画像と位置合わせする。自由度6のアフィン変換によって、悪性リンパ節の画像に対して、テンプレートの移動、サイズのスケーリング、傾斜及び回転を実施し、変換を記述するパラメーターをアルゴリズムによって最適適合度に自動調節する。適合パラメーターの適合度を、悪性リンパ節の画像とテンプレート画像の幾何学的に対応する画素濃度値間の相関係数として計算する。アルゴリズムで得られた適合度の最大値を、リンパ節がどれくらいテンプレートと類似しているかの尺度として用いる。低い値(典型的には0.8未満の値)はリンパ節での転移増殖(悪性リンパ節)を示す。
境界長に基づく分析
注射して約10〜20分後に、実施例1に記載の通りリンパ節の画像を取得する。画像を実施例1に記載の通りスムージングし、画像内のリンパ節を含む関心領域(ROI)をユーザが画定する。この領域内のメジアン画素濃度値を計算し、領域内の画素をメジアン値よりも暗いか明るいかによって、暗又は明として分割する。ROI内の画像画素列を横断して暗として分類された画素と明として分類された画素との間の移行の総数を数えることによって、明領域と暗領域の境界の長さの測定値を計算する。境界の長さは以下の通り推計される。
自己相関関数に基づく分析
リンパ節の画像を実施例3に記載の通り取得し、実施例1に記載の通りスムージングする。ROI画像の正規化2D自己相関関数を、フーリエ変換法(2Dパワースペクトルの逆変換)又は離散的計算法によって計算する。自己相関ピークのサイズを、値が0.5を上回る自己相関マトリックス内の画素数として推定する。自己相関関数の主ピークに関係しない局所ピークを表す画素は無視する。約4mm2の画像面積に相当する数値よりも大きな数値はリンパ節での転移組織の領域による粗いテクスチャを示す。
Claims (9)
- 超音波造影剤を事前に投与しておいた被検体からのリンパ節の超音波画像を、リンパ節のコントラスト増強パターンの粗さの定量的尺度が得られるように処理する方法であって、前記処理が境界の長さの測定値に基づくものであり、当該方法が、以下の段階a)〜c)
a)リンパ節を示す画像の領域を識別する段階、
b)上記領域をコントラスト増強領域と非増強領域とに分割する段階、及び
c)増強領域と非増強領域との境界の長さを測定し、得られた測定値を上記領域の総面積で除す段階
を含む、方法。 - 前記超音波造影剤が、マトリックス材料と、ガス又はガス前駆体又はこれらの混合物とを含む、請求項1記載の方法。
- 前記超音波造影剤が、直径約0.25〜15μmの平均粒径と、圧力120mmHgで50%以上の圧力安定性とを有する、請求項2記載の方法。
- 前記超音波画像が、1回に又は複数の異なる時点で取得される、請求項1乃至請求項3のいずれか1項記載の方法。
- 前記超音波画像が、2次元又は3次元で取得される、請求項1乃至請求項4のいずれか1項記載の方法。
- 超音波造影剤を事前に投与しておいた被検体からのリンパ節の超音波画像を、フィリングパターンのコントラスト増強の定量的尺度が得られるように超音波画像を処理する方法であって、当該方法が、以下の段階a)〜c):
a)正常リンパ節の画像に基づいてテンプレートを得る段階、
b)被検体からのリンパ節の画像にテンプレートを幾何学的にフィットさせる段階、及び
c)最適適合パラメーターを計算する段階
を含む、方法。 - 前記処理が一連の画像に基づく、請求項6記載の方法。
- リンパ節の中心領域と周縁領域との間のコントラスト増強が現れる時間的及び/又は空間的ずれの推定を含む、請求項7記載の方法。
- 以下の段階a)〜c):
a)周縁部から中心への複数の同心円領域でモデルをリンパ節にフィットさせる段階、
b)同心円領域の各々についてコントラスト増強が現れる時間を計算する段階、及び
c)コントラスト増強が現れる時間差を計算する段階
を含む、請求項7記載の方法。
Applications Claiming Priority (3)
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NO20035401A NO20035401D0 (no) | 2003-12-04 | 2003-12-04 | Metode |
NO20035401 | 2003-12-04 | ||
PCT/NO2004/000372 WO2005053538A2 (en) | 2003-12-04 | 2004-12-03 | Method |
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JP2007512894A JP2007512894A (ja) | 2007-05-24 |
JP4700011B2 true JP4700011B2 (ja) | 2011-06-15 |
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JP2006542522A Expired - Fee Related JP4700011B2 (ja) | 2003-12-04 | 2004-12-03 | リンパ節の超音波画像の処理方法 |
Country Status (5)
Country | Link |
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US (1) | US20070066893A1 (ja) |
EP (1) | EP1696798A2 (ja) |
JP (1) | JP4700011B2 (ja) |
NO (1) | NO20035401D0 (ja) |
WO (1) | WO2005053538A2 (ja) |
Cited By (1)
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KR102092614B1 (ko) | 2018-10-22 | 2020-03-24 | 휴켐스주식회사 | 1,4-디이오도벤젠을 이용한 4,4'-옥시디아닐린의 제조방법 |
Families Citing this family (6)
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JP5407014B2 (ja) * | 2006-03-17 | 2014-02-05 | ジンマー,インコーポレイティド | 切除する骨の表面の輪郭線をあらかじめ決定し、骨へのプロテーゼのフィット状態を評価する方法 |
US9179983B2 (en) * | 2007-08-14 | 2015-11-10 | Zimmer, Inc. | Method of determining a contour of an anatomical structure and selecting an orthopaedic implant to replicate the anatomical structure |
US9364196B2 (en) * | 2008-12-12 | 2016-06-14 | Signostics Limited | Method and apparatus for ultrasonic measurement of volume of bodily structures |
JP2013135801A (ja) * | 2011-12-28 | 2013-07-11 | Shinshu Univ | センチネルリンパ節内部を描出する画像診断装置及びその作動方法 |
JP5984243B2 (ja) * | 2012-01-16 | 2016-09-06 | 東芝メディカルシステムズ株式会社 | 超音波診断装置、医用画像処理装置及びプログラム |
DE102019003351A1 (de) * | 2019-05-10 | 2020-11-12 | Farzaneh Yousefi | Verfahren zur Beurteilung eines Kontrastmittelaufnahmemuster |
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US5425366A (en) * | 1988-02-05 | 1995-06-20 | Schering Aktiengesellschaft | Ultrasonic contrast agents for color Doppler imaging |
IN172208B (ja) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
GB9107628D0 (en) * | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
JP3974946B2 (ja) * | 1994-04-08 | 2007-09-12 | オリンパス株式会社 | 画像分類装置 |
NZ331509A (en) * | 1996-02-19 | 2000-04-28 | Nycomed Imaging As | Aqueous dispersions of stabilised gas microbubbles and their use as contrast agents |
US6317617B1 (en) * | 1997-07-25 | 2001-11-13 | Arch Development Corporation | Method, computer program product, and system for the automated analysis of lesions in magnetic resonance, mammogram and ultrasound images |
US6996549B2 (en) * | 1998-05-01 | 2006-02-07 | Health Discovery Corporation | Computer-aided image analysis |
US6444192B1 (en) * | 1999-02-05 | 2002-09-03 | The Regents Of The University Of California | Diagnostic imaging of lymph structures |
EP1202671A4 (en) * | 1999-08-13 | 2004-11-10 | Point Biomedical Corp | MICROPARTICLES USEFUL AS ULTRASONIC CONTRAST AGENTS FOR THE LYMPHATIC SYSTEM |
WO2001078005A2 (en) * | 2000-04-11 | 2001-10-18 | Cornell Research Foundation, Inc. | System and method for three-dimensional image rendering and analysis |
US20020186875A1 (en) * | 2001-04-09 | 2002-12-12 | Burmer Glenna C. | Computer methods for image pattern recognition in organic material |
EP1549938A4 (en) * | 2002-04-26 | 2010-05-12 | Univ Johns Hopkins | IDENTIFICATION OF BIOMARKERS TO DETECT PROSTATE CANCER |
WO2005070472A2 (en) * | 2004-01-20 | 2005-08-04 | Sunnybrook And Women's College Health Sciences Centre, | High frequency ultrasound imaging using contrast agents |
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- 2004-12-03 JP JP2006542522A patent/JP4700011B2/ja not_active Expired - Fee Related
- 2004-12-03 US US10/558,597 patent/US20070066893A1/en not_active Abandoned
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KR102092614B1 (ko) | 2018-10-22 | 2020-03-24 | 휴켐스주식회사 | 1,4-디이오도벤젠을 이용한 4,4'-옥시디아닐린의 제조방법 |
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JP2007512894A (ja) | 2007-05-24 |
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US20070066893A1 (en) | 2007-03-22 |
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