JP4639189B2 - マイクロ流体装置 - Google Patents
マイクロ流体装置 Download PDFInfo
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- JP4639189B2 JP4639189B2 JP2006530369A JP2006530369A JP4639189B2 JP 4639189 B2 JP4639189 B2 JP 4639189B2 JP 2006530369 A JP2006530369 A JP 2006530369A JP 2006530369 A JP2006530369 A JP 2006530369A JP 4639189 B2 JP4639189 B2 JP 4639189B2
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Description
−その厚みのある部分の中に、1または複数のチャンバが、少なくとも一部形作られている第一プレート、
−チャンバの少なくとも一つを外部から隔離するように設計された少なくとも一つの密閉部材、
−1または複数のマイクロチャネルを支持する支持体、
を含み、この支持体が特に二枚の重畳プレートを含み、一つは単数または複数のマイクロチャネルの底部を画定し、もう一方がその上壁を画定し、支持体は第一プレートに押付けることができ、それぞれのチャンバは密閉された形でマイクロチャネルの一端部と連通しているマイクロ流体装置である。
−マイクロチャネル、
−ダクトを介してマイクロチャネルの一端と連通しているチャンバ、
−チャンバ内に挿入し、ダクトの端部近くに開口しているチューブ、
を含むマイクロ流体装置である。
−前記製品を、上記のマイクロ流体装置のマイクロチャネルまたはマイクロチャネルネットワークを通して循環させるステップ、および
−マイクロチャネルまたはマイクロチャネルネットワーク内の前記製品の流速、またはマイクロチャネルの端部間の圧力差を監視するステップを含むことを特徴とする。
−前記製品を、上記のマイクロ流体装置のマイクロチャネルまたはマイクロチャネルネットワークを通して循環させるステップ、および
−マイクロチャネルまたはマイクロチャネルネットワーク内の前記製品の流速、または単数または複数のマイクロチャネルの端部間の圧力差を監視するステップを含むことを特徴とする。
図1は、本発明の第一実施形態による、一端部3で第一圧力源4に接続し、もう一方の端部5で、可撓性ダクト7を介してチャンバ6に接続している、マイクロチャネル2を含むマイクロ流体装置を示す。
I=r4P/8L
式中rはマイクロチャネルの半径であり、Lは長さである。
P=RI
式中Rはマイクロ流体抵抗と呼ばれ、次の概略式で与えられる:
R=8L/r4
図2は、チャンバ6、6’の各端部3、5に接続するマイクロチャネル2を含む、装置1に相当類似しているマイクロ流体装置である。
図3は、本発明の別の実施例によるマイクロ流体装置40を示している。
図5−7に表されている本実施例では、マイクロ流体装置90は、その厚みの中にチャンバ92−95が形作られているプレート91を含む。各チャンバは、出口オリフィス96−99を介してプレート91の下側の方に向いて開口している。
第一応用例:電気泳動法によるDNAの分離
顕微鏡80のステージに位置決めされた磁気コイル内に、セル41を置く。
この応用例においては、トリプシンの支持体として作動する磁気ヘッドを、単数または複数のマイクロチャネルに導入する。これらのヘッドは、磁石を用いて固定する。次いで、消化すべき蛋白質を含む製品を、単数または複数のマイクロチャネルを通して循環させる。
この応用例においては、触媒をマイクロチャネルの壁に対して、または磁石により不動になる磁気ヘッドに対して固定する。
装置40のマイクロチャネルの交叉構成のネットワークを使用して、二つの試薬を、二つのマイクロチャネル、例えば42と45から、マイクロチャネルの交叉点に送って、そこで生じる反応の動力学を観測することが出来る。例えば、別の二つのマイクロチャネル43と44は、反応生成物を除去するのに用いることが出来る。
Claims (22)
- 第一流体を含み、かつ一端がチャンバ(6、6’、47−50、92−95)に接続される少なくとも一つのマイクロチャネル(2、42−45、100−103)を備えるマイクロ流体装置(1、1’、40、90)において、
前記チャンバと流体連通される入口回路(8、8’、124)と出口回路(9、9’、125)とがさらに備えられ、
前記入口回路及び出口回路にはそれぞれの圧力が異なる圧力源(4;10)が含まれ、
前記マイクロチャネルの他端は前記出口回路に含まれる前記圧力源に接続され、
前記入口回路から前記チャンバとの流体連通箇所まで、及び該箇所から前記出口回路まで、連続的な第二流体の流れがマイクロチャネルに接触することなく確立されており、
前記入口回路と出口回路の少なくとも一方には、マイクロチャネルの他端における圧力に依存することなく、マイクロチャネルの前記一端における圧力を変更できるように入口回路と出口回路中における流速を調整する漸進的に制御可能な弁が含まれていること、
を特徴とするマイクロ流体装置。 - 前記第二流体はマイクロチャネル(2、42−45、100−103)に含まれる第一流体とは異なることを特徴とする請求項1に記載の装置。
- 前記第二流体が気体であることを特徴とする請求項2に記載の装置。
- 前記第一流体が液体であることを特徴とする請求項2又は3に記載の装置。
- 前記マイクロチャネル(2、42−45、100−103)が、好ましくは1mm-1より大きく、好適には4mm-1より大きい、更に好適には10mm-1又は1μm-1より大きい表面積/体積比を有することを特徴とする請求項1〜4のうちいずれか一項に記載の装置。
- 前記チャンバ(6、6’、47−50、92−95)の容積が、10mm3と5mlとの間に含まれることを特徴とする請求項1〜5のうちいずれか一項に記載の装置。
- 前記入口回路及び出口回路のうち少なくとも一方における、特に出口回路における水力学的損失が、マイクロチャネルにおける水力学的損失より小さく、好適には少なくとも10倍だけ小さく、さらに好適には、n>2として、10n培小さいことを特徴とする請求項1〜6のうちいずれか一項に記載の装置。
- 前記マイクロチャネルは、チャンバに対しダクト(7)を用いて接続され、好適には一種又は数種の液体で全体が満たされていることを特徴とする請求項1〜7のうちいずれか一項に記載の装置。
- 前記出口回路とマイクロチャネルの一端部とが、共通圧力源(4)を用いて連通していることを特徴とする請求項1〜8のうちいずれか一項に記載の装置。
- 前記弁が、ソレノイド弁又はニードル弁であることを特徴とする請求項1〜9のういちいずれか一項に記載の装置。
- 前記入口回路及び出口回路のうち少なくとも一方が、前記入口回路又は出口回路を、流量又は圧力に関連する情報項目を関数として制御可能な動力学的調整システム(18)に接続されることを特徴とする請求項1〜10のうちいずれか一項に記載の装置。
- 前記情報項目が、異なる動作範囲を有するセンサ、詳細には圧力又は流量センサ、のカスケードにより分配されることを特徴とする請求項11に記載の装置。
- 前記単数又は複数のマイクロチャネルが、支持体の上又は中に、エングレーヴィング、成形、押出し成形又は射出成形、熱間又は冷間圧縮、などにより製造されることを特徴とする請求項1〜12のうちいずれか一項に記載の装置。
- それぞれのチャンバが、ダクトを介してマイクロチャネルの一端部と連通すること、
それぞれのチャンバに対する液体製品の供給が、ダクトと開口部との中に導入されてその端部に開口したチューブを介して行われること、
を特徴とする請求項1〜13のうちいずれか一項に記載の装置。 - 前記マイクロチャネルが、それぞれの端部においてチャンバに接続しており、それぞれのチャンバが入口回路及び出口回路に連通しており、この回路間では結合されたチャンバ内に流体の流れが確立することを特徴とする請求項1〜14のうちいずれか一項に記載の装置。
- 複数のマイクロチャネルを備え、そのうち少なくとも二つはそれぞれその一端部においてチャンバに接続されており、それぞれのチャンバが、回路間に第二の流体の流れを確立する入口回路及び出口回路に連通しており、入口回路及び出口回路のうち少なくとも一方が、前記マイクロチャネルの端部における圧力を変更するよう制御可能であることを特徴とする請求項1〜15のうちいずれか一項に記載の装置。
- 少なくとも一つの電極、好適には二つの電極を含むことを特徴とする請求項1〜16のうちいずれか一項に記載の装置。
- 前記電極がチャンバ内に配置され、前記チャンバが導電性液体を介してマイクロチャネルに連通していることを特徴とする請求項17に記載の装置。
- 少なくとも部分的に形成される一つ又は複数のチャンバをプレート上に備え、前記プレートが、単数又は複数の関連するマイクロチャネルを画定するプレートからは分離されることを特徴とする請求項1〜18のうちいずれか一項に記載の装置。
- 次の応用法のうちいずれか一つで、請求項1〜19のうちいずれか一項に記載の装置の使用であり、
前記装置内の製品に含まれる生物種の診断、分析、精製又は取扱の各方法、生物種を合成する方法、生物種の物理的又は化学的特性を変更する方法、ハイスループットスクリーニング方法又は薬剤調査方法、クロマトグラフィ、エレクトロ−クロマトグラフィ、又は電気泳動の方法、又は装置内に熱を運ぶ方法を含むことを特徴とする装置の使用。 - 第一流体中に含まれる物質を分離、又は化学反応又は状態の変化を監視する方法であって、
請求項1から19のうちいずれか一項に記載のマイクロ流体装置のマイクロチャネル又はマイクロチャネルのネットワークを通って前記第一流体を流れさせるステップと、
前記マイクロチャネル又は前記マイクロチャネルのネットワークにおける前記第一流体の流速、若しくは単数又は複数のマイクロチャネルの端部間の圧力差、のいずれかを監視するステップと
を含むことを特徴とする方法。 - マイクロチャネルの一端へ接続可能な少なくとも一つのチャンバと、
前記チャンバと流体連通状態にあり、かつ圧力源を備える入口回路及び出口回路とを有し、
それぞれの圧力が異なることで、マイクロチャネルと接触することなく、前記入口回路から前記チャンバと流体連通されている箇所まで、及び該箇所から出口回路までの、流体の連続流が確立でき、
前記入口回路及び出口回路の少なくとも一方が、マイクロチャネルの前記一端における圧力を、マイクロチャネルの他端における圧力に依存することなく、変更できるように入口回路と出口回路中における流速を調整する漸進的に制御可能な弁を備え、
マイクロチャネルが本システムへモジュール方式で接続できるように設計されていることを特徴とする圧力モニターシステム。
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- 2003-05-21 FR FR0306119A patent/FR2855076B1/fr not_active Expired - Lifetime
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2004
- 2004-05-19 WO PCT/FR2004/001236 patent/WO2004103566A1/fr active Application Filing
- 2004-05-19 CN CN2004800188528A patent/CN1816393B/zh not_active Expired - Lifetime
- 2004-05-19 US US10/557,308 patent/US7972561B2/en active Active
- 2004-05-19 JP JP2006530369A patent/JP4639189B2/ja not_active Expired - Lifetime
- 2004-05-19 CA CA 2526205 patent/CA2526205C/fr not_active Expired - Lifetime
- 2004-05-19 EP EP04742779.4A patent/EP1628769B1/fr not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1628769B1 (fr) | 2018-07-04 |
US20060275179A1 (en) | 2006-12-07 |
CN1816393B (zh) | 2011-05-18 |
CA2526205C (fr) | 2012-03-13 |
CN1816393A (zh) | 2006-08-09 |
FR2855076B1 (fr) | 2006-09-08 |
FR2855076A1 (fr) | 2004-11-26 |
EP1628769A1 (fr) | 2006-03-01 |
WO2004103566A1 (fr) | 2004-12-02 |
JP2007511744A (ja) | 2007-05-10 |
US7972561B2 (en) | 2011-07-05 |
CA2526205A1 (fr) | 2004-12-02 |
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