JP4543112B2 - 口腔湿潤効果をもたらす組成物、送達システム及び製造方法 - Google Patents
口腔湿潤効果をもたらす組成物、送達システム及び製造方法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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Description
本明細に記載の実施態様により、個人により消費される際に口内が潤う感覚がもたらされる口腔用組成物が提供される。したがって、組成物は、種々の生理的要因及び環境的要因に関連する口喝感を軽減させることができる。
ある実施態様により、上述の口腔湿潤組成物のための送達システム又は送達手段が提供される。通常、送達システム(「食品」とも呼ばれる)には、食品及び飲料等の、任意の食用又は消耗品組成物が含まれる。より具体的には、食品は、ハードキャンディー、ソフトキャンディー、綿あめ、センターフィル型キャンディー、圧縮タブレット、チューインガム、センターフィル型チューインガム、フィルム、トローチ、液体飲料、粉末飲料等が挙げられるがこれらに限定されない形態より選択することができる。このような食品は、口腔湿潤組成物、香味料を含んでいてよく、担体を任意に含んでいてもよい。
(a)ジヒドロカルコン、モネリン、ステビア、ステビオシド、レバウジオシドA、グリシルリジン、ジヒドロフラベノール、及びソルビトール、マンニトール、マルチトール、キシリトール、エリスリトール等の糖アルコール、及び米国特許第4,619,834号明細書(該明細書の記載は、参照により本明細書に組み込まれる)に開示されたもの等のL−アミノジカルボン酸アミノアルケン酸エステルアミド、並びにこれらの混合物等の水溶性甘味料;
(b)可溶性サッカリン塩(サッカリンナトリウム塩又はカルシウム塩)、チクロ塩、3,4−ジヒドロ−6−メチル−1,2,3−オキサチアジン−4−オン−2,2−ジオキシドのナトリウム塩、アンモニウム塩、又はカルシウム塩、3,4−ジヒドロ−6−メチル−1,2,3−オキサチアジン−4−オン−2,2−ジオキシドのカリウム塩(アセスルフェームK)、遊離酸型のサッカリン、及びこれらの混合物等の水溶性人工甘味料;
(c)L−アスパルチル−L−フェニルアラニンメチルエステル(アスパルテーム)、及び米国特許第3,492,131号明細書に記載の物質、L−α−アスパルチル−N−(2,2,4,4−テトラメチル−3−チエタニル)−D−アラニンアミド水和物(アリテーム)、N−[N−(3,3−ジメチルブチル)−L−α−アスパルチル]−L−フェニルアラニン 1−メチルエステル(ネオテーム)、L−アスパルチル−L−フェニルグリセリンのメチルエステル及びL−アスパルチル−L−2,5−ジヒドロフェニルグリシン、L−アスパルチル−2,5−ジヒドロ−L−フェニルアラニン、L−アスパルチル−L−(1−シクロヘキセン)−アラニン等のL−アスパラギン酸誘導体甘味料、及びこれらの混合物等の、ジペプチド系甘味料;
(d)例えば、スクラロースの商品名で知られているクロロデオキシスクロース又はクロロデオキシガラクトスクロースの誘導体等のクロロデオキシ糖誘導体等の、通常の砂糖(スクロース)の塩素化誘導体等の天然の水溶性甘味料から誘導される水溶性甘味料;クロロデオキシスクロース及びクロロデオキシガラクトスクロース誘導体の例としては、1−クロロ−1’−デオキシスクロース、4−クロロ−4−デオキシ−α−D−ガラクトピラノシル−α−D−フルクトフラノシド、又は4−クロロ−4−デオキシガラクトスクロース、4−クロロ−4−デオキシ−α−D−ガラクトピラノシル−1−クロロ−1−デオキシ−β−D−フルクト−フラノシド、又は4,1’−ジクロロ−4,1’−ジデオキシガラクトスクロース、1’,6’−ジクロロ−1’,6’−ジデオキシスクロース、4−クロロ−4−デオキシ−α−D−ガラクトピラノシル−1,6−ジクロロ−1,6−ジデオキシ−β−D−フルクトフラノシド、又は4,1’,6’−トリクロロ−4,1’,6’−トリデオキシガラクトスクロース、4,6−ジクロロ−4,6−ジデオキシ−α−D−ガラクトピラノシル−6−クロロ−6−デオキシ−β−D−フルクトフラノシド、又は4,6,6’−トリクロロ−4,6,6’−トリデオキシガラクトスクロース、6,1’,6’−トリクロロ−6,1’,6’−トリデオキシスクロース、4,6−ジクロロ−4,6−ジデオキシ−α−D−ガラクト−ピラノシル−1,6−ジクロロ−1,6−ジデオキシ−β−D−フルクトフラノシド、又は4,6,1’,6’−テトラクロロ−4,6,1’,6’−テトラデオキシガラクト−スクロース、及び4,6,1’,6’−テトラデオキシ−スクロース、並びにこれらの混合物等が挙げられるが、これらに限定されない;
(e)タウマッコスダニエリ(タウマチンI及びII)及びタリン等のタンパク質系甘味料;
(f)甘味料モナチン(2−ヒドロキシ−2−(インドール−3−イルメチル)−4−アミノグルタル酸)及びその誘導体;並びに
(g)甘味料羅漢果(Lo han guo)(「Lo han kuo」と呼ばれる場合もある)。
表1:口腔湿潤組成物
表2:ハードボイルドキャンディー中の口腔湿潤組成物
表3:ソフト/チューイーキャンディー中の口腔湿潤組成物
表4及び5:センターフィル型ハードボイルドキャンディー中の口腔湿潤組成物
表4:ハードキャンディーのシェルの組成(80%)
表6:板状チューインガム中の口腔湿潤組成物
表7及び8:センターフィル型チューインガム中の口腔湿潤組成物
表7:ガム/シェルの組成(80%)
表9:シュガーフリー圧縮ミント
表10:糖含有圧縮ミント
表11、12、13、及び14:センターフィル型ハードボイルドキャンディー中の口腔湿潤組成物
Claims (24)
- (a)
(i)スクロースと、イソマルトと、
(ii)食品に対し2.5〜4.5質量%存在するリンゴ酸と、
(iii)食品に対し0.04〜0.2質量%存在する清涼剤と、の混合物を含んでなる組成物と、
(b)香味料と、
(c)担体とを含んでなる食品。 - 前記食品が更にマルチトールを含む、請求項1に記載の食品。
- 前記スクロースと、イソマルトとが前記食品に対し0.05〜99.5質量%存在する、請求項1に記載の食品。
- 更に油脂、油、アロエベラ、ペクチン及びこれらの組み合わせから成る群から選ばれる滑沢剤を含む、請求項1に記載の食品。
- 前記食品の縁は滑らかである、請求項1に記載の食品。
- 前記食品が鋳型に鋳込まれている、請求項1に記載の食品。
- 前記清涼剤が、メントール、キシリトール、エリスリトール、メンタン、メントン、酢酸メンチル、サリチル酸メンチル、N,2,3−トリメチル−2−イソプロピルブタナミド、N−エチル−p−メンタン−3−カルボキサミド、コハク酸メンチル、3−l−メントキシプロパン−1,2−ジオール、グルタル酸エステル及びこれらの組み合わせから成る群から選ばれる、請求項1に記載の食品。
- 前記清涼剤がグルタル酸エステル及びN,2,3−トリメチル−2−イソプロピルブタナミドを含む、請求項1に記載の食品。
- メントールを含まない、請求項1に記載の食品。
- 前記香味料が柑橘系香料を含む、請求項1に記載の食品。
- (a)水溶性のチュワブル基材、水不溶性のチュワブル基材、及びこれらの組み合わせより選択されるチュワブル基材と、
(b)
(i)スクロースと、イソマルトと、
(ii)食品に対し2.5〜4.5質量%存在するリンゴ酸と、
(iii)食品に対し0.04〜0.2質量%存在する清涼剤とを含む組成物と、
(c)香味料とを含むチュワブル食品。 - 前記チュワブル食品がマルチトールを含む、請求項11に記載のチュワブル食品。
- 前記チュワブル基材がチューインガム基材を含む、請求項11に記載の食品。
- 以下の工程:
(a)
(i)食品に対し2.5〜4.5質量%存在するリンゴ酸と、
(ii)スクロースを含む食品組成物を準備する工程と、
(b)イソマルトを加えることにより食品組成物の甘味を減少させる工程であって、前記イソマルトが、前記スクロースの0.05質量%〜5質量%である工程と、
食品に対し0.04〜0.2質量%存在する清涼剤を加える工程と、を含んでなる食品が口を潤す効果を増大させる方法。 - 以下の工程:
(a)スクロースと、イソマルトとを135〜160℃に加熱する工程と、
(b)加熱したスクロース及びイソマルトに、
(i)食品に対し2.5〜4.5質量%存在するリンゴ酸と、
(ii)食品に対し0.04〜0.2質量%存在する清涼剤と、
(iii)香味料とを加える工程と、
(c)これらの成分の組み合わせより食品組成物を形成する工程とを有する、食品の調製方法。 - 前記食品組成物を形成する工程が、成分の組み合わせを冷却する工程及び冷却された成分の組み合わせを所望の形状に切断する工程を含む、請求項15に記載の方法。
- 食品を形成する工程が、成分の組み合わせを鋳型に鋳込んで食品を形成する工程を含む、請求項15に記載の方法。
- (a)センターフィル領域と、
(b)センターフィル領域を取り囲む菓子領域とを含み、
前記菓子領域が担体を含み、前記領域のうち少なくとも一方が、
(i)スクロースと、イソマルトと、
(ii)食品に対し2.5〜4.5質量%存在するリンゴ酸と、
(iii)食品に対し0.04〜0.2質量%存在する清涼剤と、
を含む、センターフィル型菓子組成物。 - 前記センターフィル領域が、粉末状のセンターフィル組成物を含む、請求項18に記載の菓子組成物。
- 口腔湿潤組成物が前記センターフィル領域中に含まれる、請求項18に記載の菓子組成物。
- 口腔湿潤組成物が前記菓子領域に含まれる、請求項18に記載の菓子組成物。
- 前記センターフィル領域が第1の口腔湿潤組成物を含み、前記菓子領域が第2の口腔湿潤組成物を含む、請求項18に記載の菓子組成物。
- 前記第1の口腔湿潤組成物は、第2の口腔湿潤組成物と同一である、請求項22に記載の菓子組成物。
- 前記第1の口腔湿潤組成物は、第2の口腔湿潤組成物と異なる、請求項22に記載の菓子組成物。
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US70775905P | 2005-08-12 | 2005-08-12 | |
PCT/US2006/031606 WO2007022069A1 (en) | 2005-08-12 | 2006-08-11 | Mouth-moistening compositions, delivery systems containing same and methods of making same |
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JP4543112B2 true JP4543112B2 (ja) | 2010-09-15 |
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US (1) | US20070031561A1 (ja) |
EP (1) | EP1922058A1 (ja) |
JP (1) | JP4543112B2 (ja) |
CN (1) | CN101242807B (ja) |
AR (1) | AR054912A1 (ja) |
AU (2) | AU2006279716B2 (ja) |
CA (1) | CA2616330C (ja) |
MX (2) | MX360951B (ja) |
WO (1) | WO2007022069A1 (ja) |
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MX2008001540A (es) | 2008-02-15 |
AU2006279716B2 (en) | 2010-04-22 |
JP2009504163A (ja) | 2009-02-05 |
AU2010203132B2 (en) | 2012-03-08 |
CN101242807B (zh) | 2014-12-10 |
US20070031561A1 (en) | 2007-02-08 |
AU2006279716A1 (en) | 2007-02-22 |
CA2616330C (en) | 2011-04-26 |
CA2616330A1 (en) | 2007-02-22 |
WO2007022069A1 (en) | 2007-02-22 |
CN101242807A (zh) | 2008-08-13 |
MX360951B (es) | 2018-11-21 |
EP1922058A1 (en) | 2008-05-21 |
AU2010203132A1 (en) | 2010-08-12 |
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