JP4532830B2 - 植物性タンパク質に基づくマイクロカプセル - Google Patents
植物性タンパク質に基づくマイクロカプセル Download PDFInfo
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- JP4532830B2 JP4532830B2 JP2002589131A JP2002589131A JP4532830B2 JP 4532830 B2 JP4532830 B2 JP 4532830B2 JP 2002589131 A JP2002589131 A JP 2002589131A JP 2002589131 A JP2002589131 A JP 2002589131A JP 4532830 B2 JP4532830 B2 JP 4532830B2
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Images
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
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- B01J13/20—After-treatment of capsule walls, e.g. hardening
- B01J13/206—Hardening; drying
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/10—Complex coacervation, i.e. interaction of oppositely charged particles
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
- General Preparation And Processing Of Foods (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
- Fertilizers (AREA)
Description
貯槽マイクロカプセルまたは貯槽系:これらは、固体の包膜、および、液体、固体またはペースト状の活性材料の芯を含む球状の粒子であり、
マトリックスミクロスフェアまたはマトリックス系:それらは、カプセル化される物質が分散される、被覆材料の連続したネットワークからなる。
正の電荷をもつ高分子と負の電荷をもつ高分子との間の複合体の形成からもたらされる、ポリマーに富み水が激減しているコアセルベート、
ポリマーが激減し水に富む上清。
a)pH 2〜7の間、かつ、そのタンパク質の等電pHより低いpHの水性媒質において、少なくとも1つの植物タンパク質を可溶化する段階、
b)a)において得られた溶液を遠心分離する段階、
c)b)において得られた上清を、その植物タンパク質のものとは反対の電荷をもつ高分子電解質の水溶液と混合する段階、
d)カプセル化される材料の存在下において、ポリマー複合体の形態における高分子電解質をコアセルベーションさせ、および選択的に、カプセルを硬化させる段階。
e)飽和に至るように、ある量の植物タンパク質を上清に添加する段階、
f)混合物を遠心分離する段階、および
g)選択的に、段階e)およびf)を数回反復する段階。
SWP100/アルギネート、SWP100/アラビアゴム、キトサン/サプロ(登録商標)、サプロ(登録商標)/アルギネートまたはサプロ(登録商標)/アラビアゴム。
pH 3に維持した10%のSWP100溶液を4,500 rpmで25分間遠心分離する。溶解されたタンパク質0.72 gを含む48 mlの上清が得られる。20 g のミグリオール(Miglyol)(登録商標)812をこの上清溶液中に乳化する。その後アルギン酸ナトリウム(0.36 g)の水溶液35.6 mlを加え、その後水96 mlを加える。媒質の温度は40℃である。1 N塩酸を加えることによって、媒質のpHを4.22から3に下げる。
pH 3に維持された、SWP100の17%溶液100 mlを、4,500 rpmにて25分間遠心分離する。2.6 gの溶解されたタンパク質を含む上清100 mlが得られる。20 gのミグリオール(登録商標)812をこの上清溶液中に乳化する。アラビアゴム(5 g)の水溶液45 mlおよび水13 mlを加える。媒質の温度は40℃である。1 N塩酸を加えることによって媒質のpHを3にまで下げる。
アルギネートの存在下においてSWP100タンパク質を用いた複合コアセルベーション
およそ15%(水130 g中に20 g)のSWP100のタンパク質溶液のpHを4の値にまで調整する。最初に溶液を12,000 rpmにて15分間遠心分離する。ペレットを取り除き、12 gのSWP100タンパク質を上清に加え、そのpHを再度4に調整する。
22.5 gの水および2.5 gのタンパク質からなるサプロ(登録商標)670溶液、および、150 gの水および1.84 gのアルギネートからなるアルギネート溶液を用い、実施例1の手順に従ってカプセルを調製する。
10%のサプロ(登録商標)670タンパク質溶液をpH 7に調整し、最初に4,500 rpmにて25分間遠心分離する。ペレットを取り除き、43 mlの水および2.57 gのタンパク質からなる上清をコアセルベーションのために使用する。
Claims (13)
- 以下の段階を含むことを特徴とする、植物タンパク質に基づくマイクロカプセルを生産するための方法:
a) 少なくとも1つの植物タンパク質を、pH 2〜7の間であり、かつ、植物タンパク質の等電pHより低いpHにおいて水性媒質に可溶化する段階、
b) 段階a)において得られる溶液を遠心分離する段階、
c) 段階b)において得られる上清に、ある量の植物タンパク質を添加する段階、および、混合物を1回もしくは数回、遠心分離する段階、
d) 段階c)において得られる上清を、植物タンパク質のものと反対の電荷を有する高分子電解質の水溶液と混合する段階、
e) カプセル化される材料の存在下において、ポリマー複合体の形態における高分子電解質をコアセルベーションさせる段階。 - 段階e)がカプセルを硬化させることをさらに含むことを特徴とする、請求項1記載の植物タンパク質に基づくマイクロカプセルを生産するための方法。
- 段階d)が植物タンパク質の等電pHより低いpHにおいて実行され、そのため、複合コアセルベーション段階e)において植物タンパク質がカチオン性高分子電解質として使用されることを特徴とする、請求項1もしくは2記載の植物タンパク質に基づくマイクロカプセルを生産するための方法。
- 段階d)が植物タンパク質の等電pHより高いpHにおいて実行され、そのため、複合コアセルベーション段階e)において植物タンパク質がアニオン性高分子電解質として使用されることを特徴とする、請求項1もしくは2記載の植物タンパク質に基づくマイクロカプセルを生産するための方法。
- 植物タンパク質が以下を含む群より選択される植物から抽出されることを特徴とする、請求項1〜4のいずれか一項記載の方法: ハウチワマメ、ダイズ、エンドウ、ヒヨコマメ、アルファルファ、ソラマメ、レンズマメ、インゲンマメ、ナタネ、ヒマワリおよび、穀類。
- 穀類が以下を含む群より選択されることを特徴とする、請求項5記載の方法: コムギ、トウモロコシ、オオムギ、麦芽およびオートムギ。
- 高分子電解質がアニオン性であり、アルギン酸ナトリウム、アラビアゴム、ポリホスフェート、カルボキシメチルセルロースナトリウム、カラゲナン、キサンタンガムおよび植物タンパク質を含む群より選択されることを特徴とする、請求項1〜3および5〜6のいずれか一項記載の方法。
- 高分子電解質がカチオン性であり、カチオン界面活性剤、第四級アンモニウムを加えたラテックス、キトサンおよび植物タンパク質を含む群より選択されることを特徴とする、請求項1、2および4〜6のいずれか一項記載の方法。
- 硬化が、ジアルデヒドおよびタンニンを含む群より選択される架橋剤を用いた架橋によって実行されることを特徴とする、請求項2記載の方法。
- ジアルデヒドがグルタルアルデヒドであることを特徴とする、請求項9記載の方法。
- タンニンがタンニン酸であることを特徴とする、請求項9記載の方法。
- カチオン性高分子電解質がキトサンである場合、無水酢酸を硬化剤として用いて硬化が実行されることを特徴とする、請求項8に記載の方法。
- 薬学分野、獣医学分野、化粧品分野、肥料分野、化学分野および生物医学分野において有用な組成物を生産するための、請求項1〜12のいずれか一項記載の方法によって得られるカプセルの使用方法。
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FR0106441A FR2824756B1 (fr) | 2001-05-16 | 2001-05-16 | Microcapsules a base de proteines vegetales |
PCT/FR2002/001652 WO2002092217A1 (fr) | 2001-05-16 | 2002-05-16 | Microcapsules a base de proteines vegetales |
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JP2004532112A JP2004532112A (ja) | 2004-10-21 |
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EP (1) | EP1390138B1 (ja) |
JP (1) | JP4532830B2 (ja) |
AT (1) | ATE335538T1 (ja) |
CA (1) | CA2447181C (ja) |
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ES (1) | ES2269715T3 (ja) |
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2001
- 2001-05-16 FR FR0106441A patent/FR2824756B1/fr not_active Expired - Lifetime
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2002
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- 2002-05-16 DK DK02738248T patent/DK1390138T3/da active
- 2002-05-16 JP JP2002589131A patent/JP4532830B2/ja not_active Expired - Fee Related
- 2002-05-16 ES ES02738248T patent/ES2269715T3/es not_active Expired - Lifetime
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- 2002-05-16 AT AT02738248T patent/ATE335538T1/de not_active IP Right Cessation
- 2002-05-16 WO PCT/FR2002/001652 patent/WO2002092217A1/fr active IP Right Grant
- 2002-05-16 DE DE60213789T patent/DE60213789T2/de not_active Expired - Lifetime
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DK1390138T3 (da) | 2006-11-27 |
DE60213789D1 (de) | 2006-09-21 |
US20040151778A1 (en) | 2004-08-05 |
DE60213789T2 (de) | 2007-08-16 |
FR2824756A1 (fr) | 2002-11-22 |
ATE335538T1 (de) | 2006-09-15 |
EP1390138A1 (fr) | 2004-02-25 |
JP2004532112A (ja) | 2004-10-21 |
ES2269715T3 (es) | 2007-04-01 |
WO2002092217A1 (fr) | 2002-11-21 |
CA2447181C (fr) | 2011-02-22 |
CA2447181A1 (fr) | 2002-11-21 |
EP1390138B1 (fr) | 2006-08-09 |
FR2824756B1 (fr) | 2005-07-08 |
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