JP4531840B2 - 散乱測定に於けるノイズ減少用の方法と装置 - Google Patents
散乱測定に於けるノイズ減少用の方法と装置 Download PDFInfo
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- JP4531840B2 JP4531840B2 JP2008551429A JP2008551429A JP4531840B2 JP 4531840 B2 JP4531840 B2 JP 4531840B2 JP 2008551429 A JP2008551429 A JP 2008551429A JP 2008551429 A JP2008551429 A JP 2008551429A JP 4531840 B2 JP4531840 B2 JP 4531840B2
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- 0 CC(C1(C)C2(C)*)C3(C4C)C12C41C(C)C(C)C(C)C31 Chemical compound CC(C1(C)C2(C)*)C3(C4C)C12C41C(C)C(C)C(C)C31 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
- B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
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- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
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- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Description
Claims (16)
- 散乱測定技術を使用して、一個以上のサンプルの一個以上の特性に関する光学的情報を収集する方法であって、
夫々が光散乱特性によって特徴付けられるサンプル溶液を保持するように構成された一個以上のサンプル容器を、内部に備えた基板を用意する工程と、
一個以上のサンプル溶液を複数のサンプル容器へ分配する工程と、
サンプル溶液の表面に対して角度を付けることで気泡が鏡面反射減少素子の下に閉じ込められないようにしつつ、前記サンプル溶液から一個或いはそれ以上の検出器へ反射する光を減少させるべく、複数のサンプル容器の中の少なくとも幾つかのサンプル溶液に、前記鏡面反射減少素子を適用する工程と、
光源からの光線をサンプル容器中の物体へ導く工程と、
サンプル容器中の物体で散乱された光を集め、集められた光を一個或いはそれ以上の検出器へ伝送する工程と、
検出器からの信号を解析して一個以上のサンプルの一個以上の特性を検出する工程と
を備える方法。 - 前記鏡面反射減少素子が、ゲル、油、固体、プラスティク、ガラス、可撓性固体、硬質固体、蝋状物から選ばれる一個である請求項1に記載の方法。
- 前記鏡面反射減少素子がサンプル溶液の凹凸面の曲率を減少するように構成された請求項1に記載の方法。
- 前記鏡面反射減少素子が、光源の波長範囲に対応する波長範囲の光を吸収し、
反射を更に減少するように構成された請求項1に記載の方法。 - 前記鏡面反射減少素子が、サンプル溶液の屈折率に近い或いは同じ屈折率を有する請求項1に記載の方法。
- 前記鏡面反射減少素子を少なくとも幾らかのサンプル溶液に適用する前に、鏡面反射減少素子を殺菌する工程を、更に備えた請求項1に記載の方法。
- 前記鏡面反射減少素子が直接サンプル溶液の表面の上に留まる請求項1に記載の方法。
- 前記鏡面反射減少素子が液体或いは固体からなる請求項1に記載の方法。
- 散乱測定技術を使用して一個以上のサンプルの一個以上の特性に関する光学的情報を収集するための装置であって、
光源と、
夫々が光散乱特性によって特徴付けられるサンプル溶液を保持するように構成された複数のサンプル容器を内部に備えた基板であって、複数のサンプル容器の中の少なくとも幾つかのサンプル容器が、気泡が鏡面反射減少素子の下に閉じ込められないようにサンプル溶液の表面に対して角度をなし、かつ一個或いはそれ以上の検出器への鏡面反射をする光を減少させる機能の鏡面反射減少素子を含む基板と、
光源からの光線をサンプル容器の中の物体に導くための一個以上の照明用光学素子と、
サンプル容器の中の物体からの散乱光を集め、集められた光を一個以上の検出器へと伝送する一個以上の集光用光学素子と
を備えた装置。 - 前記鏡面反射減少素子が、ゲル、油、固体、プラスティク、ガラス、可撓性固体、硬質固体、蝋状物から選ばれる一個である請求項9に記載の装置。
- 前記鏡面反射減少素子がサンプル溶液の凹凸面の曲率を減少するように構成された請求項9に記載の装置。
- 前記鏡面反射減少素子が、光源の波長範囲に対応する波長範囲の光を吸収し、
反射を更に減少するように構成された請求項9に記載の装置。 - 前記鏡面反射減少素子が、サンプル溶液の屈折率に近い或いは同じ屈折率を有する請求項9に記載の装置。
- 前記鏡面反射減少素子がサンプル容器の中に入れられる前に殺菌される請求項9に記載の装置。
- 前記鏡面反射減少素子が直接サンプル溶液の表面の上にある請求項9に記載の装置。
- 前記鏡面反射減少素子が液体或いは固体から成る請求項9に記載の装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/336,388 US7643146B2 (en) | 2006-01-20 | 2006-01-20 | Methods and apparatus for reducing noise in scatterometry measurements |
PCT/US2007/001512 WO2007084704A1 (en) | 2006-01-20 | 2007-01-19 | Method and apparatus for reducing noise in scatterometry measurements |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009524061A JP2009524061A (ja) | 2009-06-25 |
JP2009524061A5 JP2009524061A5 (ja) | 2010-03-11 |
JP4531840B2 true JP4531840B2 (ja) | 2010-08-25 |
Family
ID=38066539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2008551429A Expired - Fee Related JP4531840B2 (ja) | 2006-01-20 | 2007-01-19 | 散乱測定に於けるノイズ減少用の方法と装置 |
Country Status (4)
Country | Link |
---|---|
US (1) | US7643146B2 (ja) |
EP (1) | EP1977217A1 (ja) |
JP (1) | JP4531840B2 (ja) |
WO (1) | WO2007084704A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2902877B1 (fr) * | 2006-06-22 | 2008-09-12 | Centre Nat Rech Scient | Procede de caracterisation de l'anisotropie d'un milieu diffusant et dispositif pour la mise en oeuvre d'un tel procede |
US9360414B2 (en) | 2011-10-14 | 2016-06-07 | University of Pittsburgh—of the Commonwealth System of Higher Education | Light refraction imaging to measure liquid volume |
DE102014107934A1 (de) | 2014-06-05 | 2015-12-17 | Carl Zeiss Microscopy Gmbh | Verfahren zur mikroskopischen Abbildung von Proben an Böden von mit Fluid befüllten Töpfchen einer Mikrotiterplatte |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4599315A (en) * | 1983-09-13 | 1986-07-08 | University Of California Regents | Microdroplet test apparatus |
US4657867A (en) * | 1984-11-01 | 1987-04-14 | Becton, Dickinson And Company | Multiwell tissue culture assembly with features for reduced media evaporation |
US5082628A (en) * | 1989-09-19 | 1992-01-21 | Park Pharmaceuticals, Inc. | Luminometer |
JP3133786B2 (ja) | 1991-08-20 | 2001-02-13 | ホーヤ株式会社 | 顕微鏡観察する方法 |
DE4405375C2 (de) | 1994-02-19 | 1996-07-25 | Fritz Nerbe Nachfolger Juergen | Mikrotiterplatte |
US6074614A (en) * | 1995-06-07 | 2000-06-13 | Molecular Devices Corporation | Multi-assay plate cover for elimination of meniscus |
US6063338A (en) * | 1997-06-02 | 2000-05-16 | Aurora Biosciences Corporation | Low background multi-well plates and platforms for spectroscopic measurements |
US6517781B1 (en) * | 1997-06-02 | 2003-02-11 | Aurora Biosciences Corporation | Low fluorescence assay platforms and related methods for drug discovery |
WO2000006991A2 (en) * | 1998-07-27 | 2000-02-10 | Ljl Biosystems, Inc. | Apparatus and methods for spectroscopic measurements |
US6861035B2 (en) * | 1998-02-24 | 2005-03-01 | Aurora Discovery, Inc. | Multi-well platforms, caddies, lids and combinations thereof |
US6825042B1 (en) * | 1998-02-24 | 2004-11-30 | Vertex Pharmaceuticals (San Diego) Llc | Microplate lid |
US6814933B2 (en) * | 2000-09-19 | 2004-11-09 | Aurora Biosciences Corporation | Multiwell scanner and scanning method |
GB0001568D0 (en) * | 2000-01-24 | 2000-03-15 | Isis Innovation | Method and apparatus for measuring surface configuration |
GB0110120D0 (en) | 2001-04-25 | 2001-06-20 | Medical Res Council | Modified sample plate cover and associated method |
US6830931B2 (en) * | 2001-07-12 | 2004-12-14 | Automated Cell, Inc. | Method and apparatus for monitoring of proteins and cells |
US7170605B2 (en) * | 2003-08-25 | 2007-01-30 | Evan Francis Cromwell | Active sensor and method for optical illumination and detection |
US20050287040A1 (en) * | 2004-06-29 | 2005-12-29 | Molecular Devices Corporation | Fluorescence validation plate |
-
2006
- 2006-01-20 US US11/336,388 patent/US7643146B2/en not_active Expired - Fee Related
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2007
- 2007-01-19 WO PCT/US2007/001512 patent/WO2007084704A1/en active Application Filing
- 2007-01-19 EP EP07716833A patent/EP1977217A1/en active Pending
- 2007-01-19 JP JP2008551429A patent/JP4531840B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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US20070171417A1 (en) | 2007-07-26 |
JP2009524061A (ja) | 2009-06-25 |
US7643146B2 (en) | 2010-01-05 |
WO2007084704A1 (en) | 2007-07-26 |
EP1977217A1 (en) | 2008-10-08 |
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