JP4527727B2 - 電気スプレーノズルを備えたマイクロ流体デバイス - Google Patents
電気スプレーノズルを備えたマイクロ流体デバイス Download PDFInfo
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Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/165—Electrospray ionisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
- B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
- B05B5/0255—Discharge apparatus, e.g. electrostatic spray guns spraying and depositing by electrostatic forces only
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8158—With indicator, register, recorder, alarm or inspection means
- Y10T137/8225—Position or extent of motion indicator
- Y10T137/8242—Electrical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8158—With indicator, register, recorder, alarm or inspection means
- Y10T137/8326—Fluid pressure responsive indicator, recorder or alarm
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- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Description
解析のために質量分析計に入っているイオンガスまたは帯電された多数の小水滴中にスプレーされる。
R.S. RANSEYら著、「Generating ElectroSpray from Microchip Devices Using Electroosmotic Pumping」(Anal. Chem., 1997年, 69号, 1174〜1178頁) K. HUIKKOら著、「Poly(dimethylsiloxane) electrospray devices fabricated with diamond-like carbon-poly (dimethylsiloxane) coated SU-8 masters」(Lab Chip, 2003年, 3号,67〜72頁 M. SVEDERBERGら著、「Sheathless Electrospray from Polymer Microchips」(Anal. Chem., 2003年,75号,3934頁〜3940頁) V. GOBRYら著、「Microfabricated polymer injector for direct mass spectrometry coupling」(Proteomics 2002年, 2号,405頁〜412頁) Y. TACHIBANAら著、「Robust and simple interface for microchip electrophoresis-mass spectrometry」(J. of Chromatography, 1011 (2003年),181頁〜192頁)
-電気スプレー(プルームタイプの)ノズルのみで動作条件に従わなければならない
-2つの構成要素間の良好な流体的接続、すなわち最小の損失体積を保証しなければならない
-ノズルのレベルにおいて液体に電位を掛けることを可能にしつつ電極を統合しなければならない。
2つの構成要素、すなわち、
−マイクロ工学技術によって作られた電気スプレーノズル(特に「プルーム」タイプノズル)、
−平坦なマイクロ流体デバイス
を組み込むことによって、電気スプレーノズルを備えたマイクロ流体デバイスを製造することを可能にする。
遺伝子の解析、
プロテオミクス(proteomics)(たん白質の特定)、
薬の開発、
のために使うことができる。
2 プレート
3 先端部
4 キャピラリースロット
5 終端
10 マイクロ流体チップ
11 マイクロ流体チャンネル
12 出口アパーチャ
15 接着剤(電極)
16 接触素子
17 電気リード
20 製作基板
21 マイクロ流体チップ(電気スプレーノズル、電気スプレー構造)
22 プレート
23 先端部
24 キャピラリースロット
25 終端
26 接触グルーブ
30 マイクロ流体チップ
31 マイクロ流体チャンネル
32 出口アパーチャ
40 製作基板
41 電気スプレーノズル
42 プレート
43 先端部
44 キャピラリースロット
45 終端
46 脚
47 グルーブ
50 マイクロ流体チップ
51 マイクロ流体チャンネル
52 出口アパーチャ
53 リセス
54 接着剤
60 金ワイヤー
61 テストプローブ
70 シリコン基板
71 犠牲層
72 堆積物
73 プレート
74 先端部
75 キャピラリースロット
76 終端
Claims (9)
- 電気スプレー構造(1,21,41)に組み込まれたマイクロ流体チップ(10,30,50)を含むマイクロ流体デバイスであって、前記マイクロ流体チップは、出口アパーチャ(12,32,52)を通してマイクロ流体チップの表面領域に連通する少なくとも1つのマイクロ流体チャンネル(11,31,51)を含み、前記電気スプレー構造は少なくとも1つの細く平らな先端部(3,23,43)を含み、その先端部には、スプレーされる液体を噴出するためのアパーチャを形成するために前記先端部の終端(5,25,45)で終わるキャピラリースロット(4,24,44)が提供され、前記電気スプレー構造は、前記先端部がマイクロ流体チップに対して片持ちされるように、またマイクロ流体デバイスの出口アパーチャが前記先端部のキャピラリースロットに連通するように、マイクロ流体チップの表面領域に配置され、前記マイクロ流体デバイスは、スプレーされる液体に電気スプレー電圧を印加するための手段をも有することを特徴とするマイクロ流体デバイス。
- マイクロ流体チップ(10,30,50)は接着剤(15,35,54)によって電気スプレー構造(1,21,41)に組み込まれることを特徴とする請求項1に記載のマイクロ流体デバイス。
- 前記接着剤が導電性であることにより、電気スプレー電圧を印加するための手段は、電気スプレー電極を形成するために、マイクロ流体チャンネル(11)の出口アパーチャ(12)のレベルにおいて、キャピラリースロット(4)に延在する前記接着剤(15)の層を含むことを特徴とする請求項2に記載のマイクロ流体デバイス。
- 電気スプレー電圧を印加するための手段は、粘着性の層(15)に電気的に接続され、マイクロ流体チップ(10)上に位置する接触素子(16)を含み、外部の電気接続を可能にすることを特徴とする請求項3に記載のマイクロ流体デバイス。
- 電気スプレー構造(21,41)は導電性素子(20,40)に固定され、その導電性素子の一部分が、電気スプレー電極を形成するために、マイクロ流体チャンネルの出口アパーチャを基準にして、キャピラリースロット(24、44)の反対側に配置されることを特徴とする請求項1または2に記載のマイクロ流体デバイス。
- 電気スプレー構造(21)は、マイクロ流体チャンネル(31)の出口アパーチャ(32)のレベルにおいてマイクロ流体チャンネル(31)が開口して導電性素子を露出するために、前記電気スプレー構造の厚さ方向に形成された接触グルーブ(26)を有することを特徴とする請求項5に記載のマイクロ流体デバイス。
- 導電性素子(20、40)は、電気スプレー構造(21、41)を作るための基板を構成する素子であることを特徴とする請求項5または6に記載のマイクロ流体デバイス。
- 電気スプレー構造(41)は、マイクロ流体チップ(50)のリセス(53)に受容されるのに適した脚(46)を含むことを特徴とする請求項1または2に記載のマイクロ流体デバイス。
- 脚(46)はグルーブ(47)を有し、前記脚(46)と前記リセス(53)は、前記リセスのベースに位置するマイクロ流体チャンネル(51)の出口アパーチャ(52)とキャピラリースロットとの間での流体の伝達が、グルーブ(47)によって確実となるように配置されることを特徴とする請求項8に記載のマイクロ流体デバイス。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0350821A FR2862007B1 (fr) | 2003-11-12 | 2003-11-12 | Dispositif microfluidique muni d'un nez d'electronebulisation. |
PCT/FR2004/050575 WO2005048291A1 (fr) | 2003-11-12 | 2004-11-09 | Dispositif microfluidique muni d'un nez d'electronebulisation |
Publications (2)
Publication Number | Publication Date |
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JP2007510920A JP2007510920A (ja) | 2007-04-26 |
JP4527727B2 true JP4527727B2 (ja) | 2010-08-18 |
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JP2006538909A Expired - Fee Related JP4527727B2 (ja) | 2003-11-12 | 2004-11-09 | 電気スプレーノズルを備えたマイクロ流体デバイス |
Country Status (7)
Country | Link |
---|---|
US (1) | US7411184B2 (ja) |
EP (1) | EP1714300B1 (ja) |
JP (1) | JP4527727B2 (ja) |
AT (1) | ATE447237T1 (ja) |
DE (1) | DE602004023880D1 (ja) |
FR (1) | FR2862007B1 (ja) |
WO (1) | WO2005048291A1 (ja) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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KR100634545B1 (ko) * | 2005-06-17 | 2006-10-13 | 삼성전자주식회사 | 마이크로 칩 조립체 |
FR2934179B1 (fr) * | 2008-07-24 | 2010-09-17 | Commissariat Energie Atomique | Laboratoire sur puce comprenant un reseau micro-fluidique et un nez d'electronebulisation coplanaires. |
WO2010056337A2 (en) | 2008-11-12 | 2010-05-20 | Caris Mpi, Inc. | Methods and systems of using exosomes for determining phenotypes |
JP4818399B2 (ja) * | 2009-06-15 | 2011-11-16 | 三菱電機株式会社 | 静電霧化装置及び空気調和機 |
AU2011223789A1 (en) | 2010-03-01 | 2012-09-20 | Caris Life Sciences Switzerland Holdings Gmbh | Biomarkers for theranostics |
CA2795776A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
JP5549361B2 (ja) * | 2010-05-07 | 2014-07-16 | 住友ベークライト株式会社 | マイクロ流路デバイス |
GB201011019D0 (en) | 2010-07-01 | 2010-08-18 | Weston Richard | Ionisation mass spectrometry |
US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
AU2013340414B2 (en) | 2012-10-23 | 2019-05-02 | Caris Science, Inc. | Aptamers and uses thereof |
CA2895847C (en) | 2012-12-19 | 2019-01-08 | Caris Science, Inc. | Compositions and methods for aptamer screening |
US9064680B2 (en) * | 2013-05-01 | 2015-06-23 | Ut-Battelle, Llc | AFM fluid delivery/liquid extraction surface sampling/electrostatic spray cantilever probe |
KR20160080815A (ko) | 2013-08-28 | 2016-07-08 | 카리스 라이프 사이언스 스위스 홀딩스 게엠베하 | 올리고뉴클레오티드 프로브 및 이의 용도 |
US20180066262A1 (en) | 2015-03-09 | 2018-03-08 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
CA2991045A1 (en) | 2015-06-29 | 2017-01-05 | Caris Science, Inc. | Therapeutic oligonucleotides binding c1q |
AU2016298317B2 (en) | 2015-07-28 | 2021-02-18 | Caris Science, Inc. | Targeted oligonucleotides |
CN105470097B (zh) * | 2015-12-09 | 2018-02-09 | 清华大学 | 一种夹层喷雾离子源装置及离子化方法 |
US10731166B2 (en) | 2016-03-18 | 2020-08-04 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
IL306052A (en) | 2016-05-25 | 2023-11-01 | Caris Science Inc | Oligonucleotide probes and their uses |
EP4369356A2 (en) | 2018-11-30 | 2024-05-15 | Caris MPI, Inc. | Next-generation molecular profiling |
WO2020246963A1 (en) * | 2019-06-04 | 2020-12-10 | Hewlett-Packard Development Company, L.P. | Integrated microfluidic ejector chips |
CA3163319A1 (en) | 2019-12-02 | 2021-06-10 | Caris Mpi, Inc. | Pan-cancer platinum response predictor |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US5788166A (en) * | 1996-08-27 | 1998-08-04 | Cornell Research Foundation, Inc. | Electrospray ionization source and method of using the same |
EP0958593A4 (en) * | 1997-01-27 | 2006-08-30 | California Inst Of Techn | MICRO ELECTROMECHANICAL SYSTEM ELECTROPULVERIZING TUBE FOR MASS SPECTROSCOPY |
DE19947496C2 (de) * | 1999-10-01 | 2003-05-22 | Agilent Technologies Inc | Mikrofluidischer Mikrochip |
DE19947495C2 (de) * | 1999-10-01 | 2003-05-28 | Agilent Technologies Inc | Mikrofluidischer Mikrochip |
DE10000691A1 (de) * | 2000-01-10 | 2001-07-26 | Fraunhofer Ges Forschung | Mikro-Düsen-System |
FR2865806B1 (fr) * | 2004-01-30 | 2007-02-02 | Commissariat Energie Atomique | Laboratoire sur puce comprenant un reseau micro-fluidique et un nez d'electronebulisation coplanaires |
-
2003
- 2003-11-12 FR FR0350821A patent/FR2862007B1/fr not_active Expired - Fee Related
-
2004
- 2004-11-09 JP JP2006538909A patent/JP4527727B2/ja not_active Expired - Fee Related
- 2004-11-09 EP EP04805818A patent/EP1714300B1/fr not_active Not-in-force
- 2004-11-09 US US10/578,175 patent/US7411184B2/en not_active Expired - Fee Related
- 2004-11-09 WO PCT/FR2004/050575 patent/WO2005048291A1/fr active Application Filing
- 2004-11-09 AT AT04805818T patent/ATE447237T1/de not_active IP Right Cessation
- 2004-11-09 DE DE200460023880 patent/DE602004023880D1/de active Active
Also Published As
Publication number | Publication date |
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ATE447237T1 (de) | 2009-11-15 |
EP1714300B1 (fr) | 2009-10-28 |
US20070114385A1 (en) | 2007-05-24 |
DE602004023880D1 (de) | 2009-12-10 |
EP1714300A1 (fr) | 2006-10-25 |
JP2007510920A (ja) | 2007-04-26 |
FR2862007B1 (fr) | 2005-12-23 |
FR2862007A1 (fr) | 2005-05-13 |
WO2005048291A1 (fr) | 2005-05-26 |
US7411184B2 (en) | 2008-08-12 |
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