JP4465177B2 - エマルション組成物 - Google Patents
エマルション組成物 Download PDFInfo
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- JP4465177B2 JP4465177B2 JP2003378756A JP2003378756A JP4465177B2 JP 4465177 B2 JP4465177 B2 JP 4465177B2 JP 2003378756 A JP2003378756 A JP 2003378756A JP 2003378756 A JP2003378756 A JP 2003378756A JP 4465177 B2 JP4465177 B2 JP 4465177B2
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- 239000000839 emulsion Substances 0.000 title claims description 59
- 239000000203 mixture Substances 0.000 title claims description 57
- 239000002245 particle Substances 0.000 claims description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 230000003204 osmotic effect Effects 0.000 claims description 5
- 239000002612 dispersion medium Substances 0.000 claims description 3
- 239000003921 oil Substances 0.000 description 34
- 235000019198 oils Nutrition 0.000 description 33
- 238000004945 emulsification Methods 0.000 description 22
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 13
- 230000000694 effects Effects 0.000 description 12
- 238000012360 testing method Methods 0.000 description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000000926 separation method Methods 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 7
- 239000004094 surface-active agent Substances 0.000 description 7
- 239000002537 cosmetic Substances 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 5
- 206010051055 Deep vein thrombosis Diseases 0.000 description 4
- 208000003241 Fat Embolism Diseases 0.000 description 4
- 206010047249 Venous thrombosis Diseases 0.000 description 4
- 238000004220 aggregation Methods 0.000 description 4
- 230000002776 aggregation Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000003549 soybean oil Substances 0.000 description 4
- 235000012424 soybean oil Nutrition 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 201000005060 thrombophlebitis Diseases 0.000 description 4
- 206010018910 Haemolysis Diseases 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000008588 hemolysis Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- 239000002960 lipid emulsion Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000008251 pharmaceutical emulsion Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 description 1
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 1
- 241000334993 Parma Species 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- -1 jojoba oil Substances 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 239000008239 natural water Substances 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 230000033116 oxidation-reduction process Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229940083466 soybean lecithin Drugs 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q13/00—Formulations or additives for perfume preparations
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Description
更に、エマルション組成物は、その製造工程において油滴の粒径を小さくするためにホモジナイザー等を用いて長時間処理することが必要であり、製造に要する手間や時間が多大なものとなってしまうという問題があった。
分散媒としての強アルカリイオン水と、油性成分から油滴粒子とを含むエマルション組成物であって、前記強アルカリイオン水の浸透圧が100mOsm以下であることを特徴とするエマルション組成物を要旨とする。
また、油滴粒子の平均粒径は、例えば、200nm以下が好ましい。静脈内に投与する医薬品に用いた場合に、脂肪塞栓症や血栓性静脈炎、深部静脈血栓などの副作用が起こる恐れがないためである。
(2)請求項2の発明は、
pHが8〜11であることを特徴とする請求項1に記載のエマルション組成物を要旨とする。
(実施例1−1)
まず、大豆油20gとグリセリン2.4gとをマグネチックスターラー(HS−4SP、iuchi製)を用いて攪拌することにより混合した。強アルカリイオン水であり、超還元性水であるS−100(商品名、株式会社エー・アイ・システムプロダクト製)に、上記混合物を加えて全量200gとし、沸騰水浴中、T.K.オートホモミキサーのTYPE.M(商品名、特殊機化工業株式会社製)を用いて、回転数;12765rpm、攪拌時間;30分間の条件で一次乳化を行った。
更に、この試料を、高圧ホモジナイザー(GEO Niro Soavi S.p.A Via M.da Erva Edoari、29A/A−43100 PARMA ITALY TYPE NS1001L2K)を用いて、圧力;1000bar、バス回数;40回の条件で2次乳化を行い、O/Wエマルション(エマルション組成物)を調整した。
(実施例1−2)
まず、レシチン(界面活性剤)2.4gを少量のエタノールに完全に溶かした後、大豆油20g及びグリセリン2.4gを加え、マグネチックスターラーを用いて均一に攪拌した。その後、エバポレーター(BUCHI Vacuum Controller B−720)を用いてエタノールを除去した。
更に、この試料を、高圧ホモジナイザーを用いて、圧力;1000bar、バス回数;40回の条件で2次乳化を行い、O/Wエマルション(エマルション組成物)を調製した。
(比較例1)
まず、レシチン(界面活性剤)2.4gを少量のエタノールに完全に溶かした後、大豆油20g及びグリセリン5gを加え、マグネチックスターラーを用いて均一に攪拌した。その後、エバポレーター(BUCHI Vacuum Controller B−720)を用いてエタノールを除去した。
更に、この試料を、高圧ホモジナイザーを用いて、圧力;1000bar、バス回数;40回の条件で2次乳化を行い、O/Wエマルション(エマルション組成物)を調製した。
(i)本実施例1−1のエマルション組成物では、界面活性剤を配合していないので、この実施例1−1のエマルション組成物を配合した医薬品や化粧品は、界面活性剤を多量に配合した場合の欠点である、生体膜を溶解したり、皮膚から血管へ入り全身を回って溶血の原因となったり、たんぱく質と相互作用し変性を起こすなどの問題が生じることがない。
i)乳化安定性に関する実験
実施例1−1、実施例1−2、比較例1のそれぞれについて、一次乳化及び容量補正後の試料を比色管に採取し、静置した。静置直後から1日ごとに、油滴の凝集により生じた分離相の高さを記録した。尚、一次乳化後段階での試料を用いたのは、2次乳化後の試料は極めて安定性が高く、短期間での安定性評価が困難であるためである。
ii)エマルション油滴粒子の粒径に関する試験
実施例1−1、実施例1−2、比較例1のそれぞれについて、二次乳化における高圧ホモジナイザーのパス回数が1、5、10、20、30、40の時点で、それぞれ試料を少量採取した。また、実施例1−1、実施例1−2、比較例1のそれぞれと基本的な製造方法は同一であるが、二次乳化における高圧ホモジナイザーのパス回数を50回とした試料、及び60回とした試料も作成した。
(イ)試料の調製
実施例1−1のエマルション組成物に対し、pHメータ(商品名;F−22、HORIBA製)の指示するpHが6となるように、1mol/Lの酢酸水溶液を所要量加え、PHが6の試料を調製した。同様に、pHが7、8、9である試料も調製した。
上記の様に所定のpHを6、7、8、9となるように調製した試料、及び酢酸水溶液を加えていない試料(pH=10.5)について、前記i)と同様に、試料を比色管に入れて静置したときに生じる分離相の高さにより安定性を評価した。その結果を図3及び図4に示す。尚、図3は、試験開始から180分経過までの短期間における評価結果であり、図4は、試験開始から28日間にわたる長期間の評価結果である。
(ハ)表面張力の測定
上記(イ)にて所定のpHを6、7、8、9となるように調製した試料、及び酢酸水溶液を加えていない試料(pH=10.5)について、表面張力を測定した。
測定結果を図5に示す。pHが8以上の試料では、表面張力が55.4dyne/cmと高い値を示していることから、油滴の凝集が起こっていないと考えられる。尚、pH7の試料の表面張力は44.7dyne/cmであった。
尚、本発明は前記実施例になんら限定されるものではなく、本発明を逸脱しない範囲において種々の態様で実施しうることはいうまでもない。
Claims (2)
- 分散媒としての強アルカリイオン水と、油性成分から成るエマルション粒子とを含むエマルション組成物であって、前記強アルカリイオン水の浸透圧が100mOsm以下であることを特徴とするエマルション組成物。
- pHが8〜11であることを特徴とする請求項1に記載のエマルション組成物。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003378756A JP4465177B2 (ja) | 2003-11-07 | 2003-11-07 | エマルション組成物 |
US10/803,469 US20050143476A1 (en) | 2003-11-07 | 2004-03-17 | Emulsion composite |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003378756A JP4465177B2 (ja) | 2003-11-07 | 2003-11-07 | エマルション組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005139354A JP2005139354A (ja) | 2005-06-02 |
JP4465177B2 true JP4465177B2 (ja) | 2010-05-19 |
Family
ID=34689038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2003378756A Expired - Lifetime JP4465177B2 (ja) | 2003-11-07 | 2003-11-07 | エマルション組成物 |
Country Status (2)
Country | Link |
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US (1) | US20050143476A1 (ja) |
JP (1) | JP4465177B2 (ja) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007197349A (ja) * | 2006-01-25 | 2007-08-09 | Ai System Product:Kk | 経皮吸収型薬剤 |
WO2007120500A2 (en) * | 2006-04-07 | 2007-10-25 | Ocean Nutrition Canada Ltd. | Emulsions and microcapsules with substances having low interfacial tension, methods of making and using thereof |
JP2010077060A (ja) * | 2008-09-25 | 2010-04-08 | Ai System Product:Kk | 乳液 |
JP2011026318A (ja) * | 2009-06-25 | 2011-02-10 | Soku:Kk | 強アルカリ性天然水・ホホバオイルのエマルションの製造法及び該製造法によって設けた強アルカリ性天然水・ホホバオイルのエマルション |
JP2011051983A (ja) * | 2009-08-03 | 2011-03-17 | Soku:Kk | 強アルカリ性天然水・油のエマルションの製造法及び該製造法によって設けた強アルカリ性天然水・油のエマルション |
JP2011111436A (ja) * | 2009-11-30 | 2011-06-09 | Aron World:Kk | アルカリイオン水を用いた化粧料組成物 |
JP5823202B2 (ja) * | 2011-07-29 | 2015-11-25 | 株式会社サニープレイス | 毛髪処理剤、及び当該毛髪処理剤を使用した毛髪処理方法 |
CN103110578B (zh) * | 2013-02-05 | 2014-11-12 | 广东华南药业集团有限公司 | 一种灯盏花素磷脂复合物自微乳组合物及其制备方法 |
JP2014012733A (ja) * | 2013-09-27 | 2014-01-23 | Ai System Product:Kk | 乳液 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4368188A (en) * | 1981-08-03 | 1983-01-11 | Eli Lilly And Company | Cosmetic toner formulation |
IL94806A0 (en) * | 1990-06-20 | 1991-04-15 | Ernest Bar On | Pharmaceutical preparation containing thiol derivatives together with other active compounds |
AU7796598A (en) * | 1997-06-06 | 1998-12-21 | Colgate-Palmolive Company, The | Microemulsion all purpose liquid cleaning compositions |
JP2002114992A (ja) * | 2000-07-31 | 2002-04-16 | Komeisha:Kk | 廃用油又は廃食用油の処理方法 |
EP1550637A1 (en) * | 2002-04-26 | 2005-07-06 | MIZ Co., Ltd. | Method of inhibiting oxidation, water capable of inhibiting oxidation and use thereof |
-
2003
- 2003-11-07 JP JP2003378756A patent/JP4465177B2/ja not_active Expired - Lifetime
-
2004
- 2004-03-17 US US10/803,469 patent/US20050143476A1/en not_active Abandoned
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Publication number | Publication date |
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JP2005139354A (ja) | 2005-06-02 |
US20050143476A1 (en) | 2005-06-30 |
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