JP4464317B2 - マイクロ流体装置とその継手 - Google Patents
マイクロ流体装置とその継手 Download PDFInfo
- Publication number
- JP4464317B2 JP4464317B2 JP2005140835A JP2005140835A JP4464317B2 JP 4464317 B2 JP4464317 B2 JP 4464317B2 JP 2005140835 A JP2005140835 A JP 2005140835A JP 2005140835 A JP2005140835 A JP 2005140835A JP 4464317 B2 JP4464317 B2 JP 4464317B2
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- Prior art keywords
- microfluidic device
- liquid
- joint
- flat surface
- tip
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- Expired - Fee Related
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/56—Labware specially adapted for transferring fluids
- B01L3/565—Seals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/30—Injector mixers
- B01F25/31—Injector mixers in conduits or tubes through which the main component flows
- B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
- B01F25/3132—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/30—Injector mixers
- B01F25/31—Injector mixers in conduits or tubes through which the main component flows
- B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
- B01F25/3132—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices
- B01F25/31322—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices used simultaneously
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/30—Injector mixers
- B01F25/31—Injector mixers in conduits or tubes through which the main component flows
- B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
- B01F25/3132—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices
- B01F25/31323—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices used successively
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00851—Additional features
- B01J2219/00858—Aspects relating to the size of the reactor
- B01J2219/0086—Dimensions of the flow channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00889—Mixing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00891—Feeding or evacuation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Organic Chemistry (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Quick-Acting Or Multi-Walled Pipe Joints (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Micromachines (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Description
また、上記継手は、先端部外面の長円状扁平面と該長円状扁平面に沿った楔状空間の先端の間に該各送液管および排液管の挿入により破裂する封止膜部を備えていることにある。
図1において、マイクロ流体装置1は後述するように複数の液体供給口と1個の排出口を有し両口間に微小流路を有するマイクロ流体素子10,送液系20,排液系30,マイクロ流体素子10を保持固定する装置のフレーム40,送液系20を制御する制御部50、およびマイクロ流体素子10の複数の液体供給口と1個の排出口に装着してありマイクロ流体素子10と送液系20や排液系30を結合する継手60a〜60m,60nで構成されている。
図5は送排液管ユニット24を示す斜視図で、送排液管ユニット24は各継手60a〜60m,60nに対応するように配列したパイプ形状の送液管24aa〜24amと排液管24bおよびこれらを連結している帯状の連結部材24cで一体化してある。
継手60Bは、先端部に截頭断面(先端の頭頂部を図において水平に切断したときに表れる断面)が長円状扁平面62である錐状の外斜面61Bを有し、図示していないけれども、内部には先端が該長円状扁平面62に沿った楔状の空間を有しており、溝66の両側は同じ外径としてあり、長円状扁平面62には各送液管24aa〜24amおよび排液管24bの挿入により破裂する封止膜部を備えている
この継手60Bも図3のように裏蓋12Bのフランジ部Fと溝66が嵌り合うようにして裏蓋12Bに装着する。そして、送排液管ユニット24を図6のように、その楔状空間に挿入し、長円状扁平面62から先端を突出するように刺し込むことができる。
平面でみれば、図3の裏蓋12Bと同じ形であるが、図11(a)のE−E切断線に沿った縦断面では図11(b)のように、各供給口と排出口として機能する孔12Caa〜12Cam,12Canにおけるフランジ部Fを上面と下面の間の内部に設けてあり、継手60a〜60m,60nを容易に挿入できるようにしてある。
10…マイクロ流体素子
20…送液系
24…送排液管ユニット
30…排液系
60、60a〜60m,60n…継手
Claims (2)
- 少なくとも2個の供給口から供給された種類の異なる液体を微小流路に導き該微小流路で該液体の混合もしくは化学反応を行わせて該微小流路の下流にある排出口から所望の液体を得るマイクロ流体素子と、該マイクロ流体素子の各供給口に種類の異なる該液体を送液する送液系と、該マイクロ流体素子における該排出口から所望の液体を受ける排液系を有するマイクロ流体装置において、
該各供給口と排出口は、それぞれ内部にフランジを有し、該各供給口と排出口のそれぞれに弾性部材よりなる継手を装着してあり、該各継手の先端部外面は楔状で2個の傾斜面と両傾斜面を結ぶ長円状扁平面を有し、または各該継手の先端部外面は截頭断面が長円状扁平面を有し、内部には先端が該長円状扁平面に沿った楔状の空間を有しており、
該送液系と排液系は該各継手の楔状の空間に挿入し、該長円状扁平面から該各供給口と排出口側に向けて先端を突出させた各送液管および排液管を備えており、
前記各継手は、
外周に前記フランジと嵌り合う溝を有し、
前記両傾斜面に前記長円状扁平面から張り出した肩部を設け、
前記長円状扁平面の各端部に前記各供給口と排出口側に向けて張り出した突出部を設け、
前記各継手の先端部が前記各供給口と排出口に挿入されているように装着され、
前記長円状扁平面と前記楔状空間の先端の間に該各送液管および排液管の挿入により破裂する封止膜部を備えているものであることものであること
を特徴とするマイクロ流体装置。 - 請求項1に記載のマイクロ流体装置において、前記截頭断面が長円状扁平面は、錐状の外斜面を有することを特徴とするマイクロ流体装置。
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005140835A JP4464317B2 (ja) | 2005-05-13 | 2005-05-13 | マイクロ流体装置とその継手 |
US11/418,072 US7670561B2 (en) | 2005-05-13 | 2006-05-05 | Micro fluidic device and joint therefor |
EP06009880A EP1721669B1 (en) | 2005-05-13 | 2006-05-12 | Joint and microfluidic device using the same |
AT06009880T ATE523252T1 (de) | 2005-05-13 | 2006-05-12 | Verbindung und mikroflüidisches gerät dieselbe benutzend |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005140835A JP4464317B2 (ja) | 2005-05-13 | 2005-05-13 | マイクロ流体装置とその継手 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006317309A JP2006317309A (ja) | 2006-11-24 |
JP4464317B2 true JP4464317B2 (ja) | 2010-05-19 |
Family
ID=36815637
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005140835A Expired - Fee Related JP4464317B2 (ja) | 2005-05-13 | 2005-05-13 | マイクロ流体装置とその継手 |
Country Status (4)
Country | Link |
---|---|
US (1) | US7670561B2 (ja) |
EP (1) | EP1721669B1 (ja) |
JP (1) | JP4464317B2 (ja) |
AT (1) | ATE523252T1 (ja) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101180277B1 (ko) | 2008-12-23 | 2012-09-07 | 한국전자통신연구원 | 미세 유체 제어 장치 및 그의 조립 방법 |
EP2466316B1 (en) * | 2010-12-15 | 2015-11-25 | F.Hoffmann-La Roche Ag | Fluidic systems, fluid containers and processes for washing fluid lines |
DE102013111778B3 (de) * | 2013-10-25 | 2015-04-30 | Bürkert Werke GmbH | Mikrofluidische Geräteeinheit |
US9682449B2 (en) | 2014-05-09 | 2017-06-20 | United Technologies Corporation | Repair material preform |
EP3361263B1 (en) | 2015-10-09 | 2021-02-24 | Sysmex Corporation | Specimen treatment chip |
JP6453928B2 (ja) * | 2017-03-10 | 2019-01-16 | 株式会社Dfc | 光透過性流路ユニット及び光反応装置 |
US12011716B2 (en) * | 2019-10-29 | 2024-06-18 | Quantum-Si Incorporated | Peristaltic pumping of fluids and associated methods, systems, and devices |
WO2022226050A1 (en) * | 2021-04-21 | 2022-10-27 | Quantum-Si Incorporated | Devices and methods for loading of fluidic receptacles |
US11666904B2 (en) * | 2021-07-28 | 2023-06-06 | Enplas Corporation | Fluid handling system |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6057885B2 (ja) * | 1978-07-10 | 1985-12-17 | 藤沢薬品工業株式会社 | シ−ル材 |
GB2102399B (en) * | 1982-06-24 | 1985-07-03 | Robert J Miskinis | Re-usable stopper or coupling device for ground openings in glassware |
CA1215945A (en) * | 1983-03-20 | 1986-12-30 | Bengt Gustavsson | Fluid transfer system |
US5531810A (en) | 1994-09-21 | 1996-07-02 | Merlin Instrument Company | Injection septum with dust wiper |
US6391014B1 (en) * | 1996-12-20 | 2002-05-21 | David G. Silverman | Strong diaphragm/safe needle/converting device combinations and their individual components |
JP3939556B2 (ja) | 2002-01-18 | 2007-07-04 | 富士フイルム株式会社 | マイクロミキサー |
JP2003227780A (ja) | 2002-02-01 | 2003-08-15 | Sysmex Corp | 粒子濃縮チップとそれを用いた粒子濃縮方法 |
JP2005112782A (ja) * | 2003-10-08 | 2005-04-28 | Hitachi Ltd | 混合液製造装置 |
-
2005
- 2005-05-13 JP JP2005140835A patent/JP4464317B2/ja not_active Expired - Fee Related
-
2006
- 2006-05-05 US US11/418,072 patent/US7670561B2/en not_active Expired - Fee Related
- 2006-05-12 EP EP06009880A patent/EP1721669B1/en not_active Not-in-force
- 2006-05-12 AT AT06009880T patent/ATE523252T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US7670561B2 (en) | 2010-03-02 |
JP2006317309A (ja) | 2006-11-24 |
EP1721669B1 (en) | 2011-09-07 |
ATE523252T1 (de) | 2011-09-15 |
EP1721669A2 (en) | 2006-11-15 |
US20060257263A1 (en) | 2006-11-16 |
EP1721669A3 (en) | 2010-05-12 |
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