JP4414291B2 - 貼付用のマトリックス及びそれからなる化粧料 - Google Patents
貼付用のマトリックス及びそれからなる化粧料 Download PDFInfo
- Publication number
- JP4414291B2 JP4414291B2 JP2004189484A JP2004189484A JP4414291B2 JP 4414291 B2 JP4414291 B2 JP 4414291B2 JP 2004189484 A JP2004189484 A JP 2004189484A JP 2004189484 A JP2004189484 A JP 2004189484A JP 4414291 B2 JP4414291 B2 JP 4414291B2
- Authority
- JP
- Japan
- Prior art keywords
- matrix
- mass
- patch
- hydrophilic
- gelling agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000011159 matrix material Substances 0.000 title claims description 70
- 239000002537 cosmetic Substances 0.000 title claims description 28
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 30
- 239000003349 gelling agent Substances 0.000 claims description 16
- 235000011187 glycerol Nutrition 0.000 claims description 16
- 150000005846 sugar alcohols Polymers 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000002562 thickening agent Substances 0.000 claims description 11
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims description 7
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 7
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 7
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 7
- 235000010418 carrageenan Nutrition 0.000 claims description 7
- 229920001525 carrageenan Polymers 0.000 claims description 7
- 239000000679 carrageenan Substances 0.000 claims description 7
- 229940113118 carrageenan Drugs 0.000 claims description 7
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 7
- 229920002581 Glucomannan Polymers 0.000 claims description 6
- 229940046240 glucomannan Drugs 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- -1 Tamarindough Polymers 0.000 description 41
- 239000000203 mixture Substances 0.000 description 29
- 239000010410 layer Substances 0.000 description 18
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 10
- 235000014113 dietary fatty acids Nutrition 0.000 description 10
- 239000000194 fatty acid Substances 0.000 description 10
- 229930195729 fatty acid Natural products 0.000 description 10
- 239000000499 gel Substances 0.000 description 9
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 8
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 8
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- 239000006096 absorbing agent Substances 0.000 description 7
- 239000004480 active ingredient Substances 0.000 description 7
- 238000003860 storage Methods 0.000 description 7
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- 230000000052 comparative effect Effects 0.000 description 6
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 238000000926 separation method Methods 0.000 description 5
- 239000000600 sorbitol Substances 0.000 description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000004166 Lanolin Substances 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 235000019388 lanolin Nutrition 0.000 description 4
- 229940039717 lanolin Drugs 0.000 description 4
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 4
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 4
- 229960002216 methylparaben Drugs 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 229920001155 polypropylene Polymers 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 229960003237 betaine Drugs 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 239000004745 nonwoven fabric Substances 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- YAGXZDADEJXXMM-UHFFFAOYSA-M potassium chloride hydrate Chemical compound [OH-].Cl.[K+] YAGXZDADEJXXMM-UHFFFAOYSA-M 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
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- 229940119170 jojoba wax Drugs 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000010445 mica Substances 0.000 description 2
- 229910052618 mica group Inorganic materials 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- XOJVVFBFDXDTEG-UHFFFAOYSA-N pristane Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 2
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 2
- MMXZSJMASHPLLR-UHFFFAOYSA-N pyrroloquinoline quinone Chemical compound C12=C(C(O)=O)C=C(C(O)=O)N=C2C(=O)C(=O)C2=C1NC(C(=O)O)=C2 MMXZSJMASHPLLR-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
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- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
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Description
(1)1)親水性増粘剤及び親水性ゲル化剤を合計0.5〜5質量%と、2)多価アルコールを40〜50質量%と、3)水を30〜60質量%とを含有する、貼付用のマトリックスであって、
前記親水性増粘剤がカルボキシメチルセルロース及び/又はその塩を含有し、
前記親水性ゲル化剤がカラギーナンを含有し、
前記多価アルコールが、1気圧、25℃の条件下で液体である多価アルコールを30質量%以上含有し、かつグリセリンを20質量%以上含有することを特徴とする、貼付用のマトリックス。
(2)前記親水性増粘剤と前記親水性ゲル化剤の含有比は、3:1〜1:3である、(1)に記載のマトリックス。
(3)前記親水性ゲル化剤が、さらにグルコマンナンを含有する、(1)又は(2)に記載のマトリックス。
(4)(1)〜(3)の何れかに記載のマトリックスを含む貼付剤。
(5)前記マトリックスは、適用部位に合った形状に成形されていることを特徴とする、(4)に記載の貼付剤。
(6)支持体なしにマトリックスのみで貼付するタイプの自立型貼付剤である、(4)又は(5)に記載の貼付剤。
(7)シート状パック化粧料である、(4)〜(6)の何れかに記載の貼付剤。
(8)前記マトリックスは、透明な型枠に、流動性を有するマトリックス原料を流し込み、固化させることにより成形されたものであることを特徴とする、(6)又は(7)に記載の貼付剤。
<1>本発明のマトリックスの必須成分である親水性増粘剤、及び親水性ゲル化剤
ここで、本発明でマトリックスとは、貼付剤において、有効成分の投与のために必要な構成部分であって、容易には分割できない部分をいう。例えば、支持体に薬剤を含む粘性組成物を塗工した貼付剤においては、塗工された粘性組成物層が、本発明に言うマトリックスに相当する。
る水系の製剤において、主として、ゲル化させる目的で配合される成分をいう。具体的には、カチオン化セルロース、ヒドロキシエチルセルロース、デンプン、イオン化デンプン誘導体、デンプンと合成高分子のブロック重合体、ヒアルロン酸、カラギーナン(カッパー、イオタ、ラムダ形)、ローカストビーンガム、キサンタンガム、グァーガム、ジェランガム、タマリンドウ、グルコマンナン、キチン、キトサン、プルラン、チューベロースポリサッカライド、コラーゲン、アルキル変性されていても良いカルボキシビニルポリマー、アーネストガム、ゼラチン、ペクチン、アガロース、又はこれらの塩が好ましく例示できる。特に好ましいものは、カラギーナンである。
<2>本発明のマトリックスの必須成分である多価アルコール
<3>本発明のマトリックスの必須成分である水
この様な形態を取ることにより、粘着剤層のみからなる貼付用のマトリックスと異なり、保湿成分を皮膚へ移行させる作用に優れるとともに、長時間貼付しても貼付によるかゆみや炎症を抑えることができる。又、上記量の水分を含有しても、他の必須成分との兼ね
合いにより安定なゲルが形成されているため、マトリックスが崩れることなく形状を長期間維持することができる。
<4>本発明のマトリックス及び貼付剤
脂肪酸エステル類(モノステアリン酸プロピレングリコール等)、硬化ヒマシ油誘導体、グリセリンアルキルエーテル、POEソルビタン脂肪酸エステル類(POEソルビタンモノオレエート、モノステアリン酸ポリオキエチレンソルビタン等)、POEソルビット脂肪酸エステル類(POE−ソルビットモノラウレート等)、POEグリセリン脂肪酸エステル類(POE−グリセリンモノイソステアレート等)、POE脂肪酸エステル類(ポリエチレングリコールモノオレート、POEジステアレート等)、POEアルキルエーテル類(POE2−オクチルドデシルエーテル等)、POEアルキルフェニルエーテル類(POEノニルフェニルエーテル等)、プルロニック型類、POE・POPアルキルエーテル類(POE・POP2−デシルテトラデシルエーテル等)、テトロニック類、POEヒマシ油・硬化ヒマシ油誘導体(POEヒマシ油、POE硬化ヒマシ油等)、ショ糖脂肪酸エステル、アルキルグルコシド等の非イオン界面活性剤類; ピロリドンカルボン酸ナトリウム、乳酸、乳酸ナトリウム、トリメチルグリシン等の保湿成分類; 表面を処理されていても良い、マイカ、タルク、カオリン、合成雲母、炭酸カルシウム、炭酸マグネシウム、無水ケイ酸(シリカ)、酸化アルミニウム、硫酸バリウム等の粉体類; 表面を処理されていても良い、ベンガラ、黄酸化鉄、黒酸化鉄、酸化コバルト、群青、紺青、酸化チタン、酸化亜鉛の無機顔料類; 表面を処理されていても良い、雲母チタン、魚燐箔、オキシ塩化ビスマス等のパール剤類; レーキ化されていても良い赤色202号、赤色228号、赤色226号、黄色4号、青色404号、黄色5号、赤色505号、赤色230号、赤色223号、橙色201号、赤色213号、黄色204号、黄色203号、青色1号、緑色201号、紫色201号、赤色204号等の有機色素類; ポリエチレン末、ポリメタクリル酸メチル、ナイロン粉末、オルガノポリシロキサンエラストマー等の有機粉体類; パラアミノ安息香酸系紫外線吸収剤、アントラニル酸系紫外線吸収剤、サリチル酸系紫外線吸収剤、桂皮酸系紫外線吸収剤、ベンゾフェノン系紫外線吸収剤、糖系紫外線吸収剤、2−(2’−ヒドロキシ−5’−t−オクチルフェニル)ベンゾトリアゾール、4−メトキシ−4’−t−ブチルジベンゾイルメタン等の紫外線吸収剤類; エタノール、イソプロパノール等の低級アルコール類、ビタミンA又はその誘導体、ビタミンB6塩酸塩、ビタミンB6トリパルミテート、ビタミンB6ジオクタノエート、ビタミンB2又はその誘導体,ビタミンB12、ビタミンB15又はその誘導体等のビタミンB類、α−トコフェロール、β−トコフェロール、γ−トコフェロール、ビタミンEアセテート等のビタミンE類、ビタミンD類、ビタミンH、パントテン酸、パンテチン、ピロロキノリンキノン等のビタミン類; 塩化カリウム等の粘度調整剤; メチルパラベンなどのパラベン類等の防腐剤などが好ましく例示できる。本発明のマトリックスは、上記必須成分と、任意の成分とを常法に従って処理することにより製造することが出来る。
また、目の周囲は、面積が小さく、立体的にも窪んだところであるため、通常のパック化粧料では、肌との密着性が悪い、保湿性能が劣る等の問題が生じていたが、本発明のマ
トリックスを使用すると、このような問題を解消することができる。特に、支持体を用いず本発明のマトリックスのみ適用した場合には、肌との密着性をより高めることができ適用効果を充分発揮させることができるため好ましい。
マトリックスを流し込む型としては、製造後の美観まで考慮すると、上述したように透明な素材を用いることが好ましい。また、この型は、予め貼付する箇所に適合した形状に加工しておくとよい。例えば、目の周囲に貼付する場合、目の周囲の形状に合わせ曲玉型の形状にするとよい。
(実施例1)
水 57 質量%
塩化カリウム 0.3質量%
1%トリメチルグリシン水溶液 0.5質量%
ロ)
グリセリン 30 質量%
ソルビトール 10 質量%
カラギーナン 0.8質量%
カルボキシメチルセルロース 0.7質量%
グルコマンナン 0.3質量%
1,3−ブタンジオール 0.2質量%
メチルパラベン 0.2質量%
ゲルシート状パック化粧料1と比較例1とを40℃で1ヶ月間保存し、20℃に戻した状態で形状を観察した。形状の指標としては、横幅における縮み長さを計測した。また、無作為に選択したパネラー10人にこれらのサンプルを見せ、縮みに気がついたかどうか質問した。さらに、縮みに気がついたパネラーについては、この縮みが品質上問題と思うかどうかも併せて質問した。
結果を表1に示す。
(実施例2)
実施例1と同様に40℃1ヶ月の保存試験も行った。
この化粧料においても、実施例1と同様の効果が存することが判る。
水 52 質量%
塩化カリウム 0.3質量%
1%トリメチルグリシン水溶液 0.5質量%
ロ)
グリセリン 35 質量%
ソルビトール 10 質量%
カラギーナン 0.8質量%
カルボキシメチルセルロース 0.7質量%
グルコマンナン 0.3質量%
1,3−ブタンジオール 0.2質量%
メチルパラベン 0.2質量%
実施例1と同様に40℃1ヶ月の保存試験も行った。
この化粧料においても、実施例1と同様の効果が存することが判る。
水 57 質量%
塩化カリウム 0.3質量%
1%トリメチルグリシン水溶液 0.5質量%
ロ)
グリセリン 20 質量%
ソルビトール 10 質量%
カラギーナン 0.8質量%
カルボキシメチルセルロース 0.7質量%
グルコマンナン 0.3質量%
1,3−ブタンジオール 10.2質量%
メチルパラベン 0.2質量%
(実施例4)
これらについて、同様に40℃、1ヶ月の保存試験を行った。
結果を表4に示す。
また、各パネラーには実際化粧料を使用してもらったが、比較例2の化粧料は、使用の為に型より取り出す際にゲルシートからの支持体の剥がれが観察された。
Claims (8)
- 1)親水性増粘剤及び親水性ゲル化剤を合計0.5〜5質量%と、2)多価アルコールを40〜50質量%と、3)水を30〜60質量%とを含有する、貼付用のマトリックスであって、
前記親水性増粘剤がカルボキシメチルセルロース及び/又はその塩を含有し、
前記親水性ゲル化剤がカラギーナンを含有し、
前記多価アルコールが、1気圧、25℃の条件下で液体である多価アルコールを30質量%以上含有し、かつグリセリンを20質量%以上含有することを特徴とする、貼付用のマトリックス。 - 前記親水性増粘剤と前記親水性ゲル化剤の含有比は、3:1〜1:3である、請求項1に記載のマトリックス。
- 前記親水性ゲル化剤が、さらにグルコマンナンを含有する、請求項1又は2に記載のマトリックス。
- 請求項1〜3の何れか1項に記載のマトリックスを含む貼付剤。
- 前記マトリックスは、適用部位に合った形状に成形されていることを特徴とする、請求項4に記載の貼付剤。
- 支持体なしにマトリックスのみで貼付するタイプの自立型貼付剤である、請求項4又は5に記載の貼付剤。
- シート状パック化粧料である、請求項4〜6の何れか1項に記載の貼付剤。
- 前記マトリックスは、透明な型枠に、流動性を有するマトリックス原料を流し込み、固化させることにより成形されたものであることを特徴とする、請求項6又は7に記載の貼
付剤。
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