JP4339879B2 - 一体化した液体区画を有するサンプル採取・計量デバイス - Google Patents
一体化した液体区画を有するサンプル採取・計量デバイス Download PDFInfo
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- JP4339879B2 JP4339879B2 JP2006216736A JP2006216736A JP4339879B2 JP 4339879 B2 JP4339879 B2 JP 4339879B2 JP 2006216736 A JP2006216736 A JP 2006216736A JP 2006216736 A JP2006216736 A JP 2006216736A JP 4339879 B2 JP4339879 B2 JP 4339879B2
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- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0825—Test strips
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
- G01N2001/1472—Devices not actuated by pressure difference
- G01N2001/149—Capillaries; Sponges
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
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- Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Hydrology & Water Resources (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Description
a) 計量素子中に所定容量のサンプル液体が残るように、分析するサンプル液体に計量素子を接触させるステップ、
b) サンプル採取・計量デバイスを反応キュベットの中に導入するステップ、
c) 支持体上の少なくとも1つの液体区画を開放して、この液体区画中に収容されている液体が反応キュベット中に流れ且つそこで計量素子中に含まれているサンプル液体と接触するようにし、サンプル液体を計量素子中から反応キュベット中に供給して反応混合物を形成するステップ、
d) 場合によりアナライトの測定に必要な追加の試薬を加えるステップ、および/または反応混合物を混合するステップ、
e) 特に光学的な検出方法により、アナライトについて測定される特性量に基づきアナライトを測定するステップ、
を含んでなる。
2 反応キュベット
3 分析試験システム
4 ホイル
5 第1の液体区画
6 第2の液体区画
7 支持体
8 計量素子
9 検出デバイス
10 サンプル採取・計量デバイス
11 反応キュベット
12 分析試験システム
13 ホイル
14 液体区画
15 支持体
16 計量素子
17 第2のドライケミストリー試薬
18 検出デバイス
19 第1のドライケミストリー試薬
20 反応キュベット
21 第1の支持体部分
22 第2の支持体部分
23 サンプル採取・計量デバイス
24 検出デバイス
25 収納部
26 第1の液体区画
27 第2の液体区画
28 計量素子
29 ホイル
30 分析試験システム
Claims (11)
- 所定容量のサンプル液体を採取するための計量素子と、所定容量の液体が収容されている少なくとも1つの密閉液体区画を含む支持体と、を有するサンプル採取・計量デバイスであって、
該計量素子が支持体と一体化した構成部品であり、該液体区画に収容されている液体はサンプル液体と混合される液体であり、支持体上の該液体区画が開放可能であり、その結果、該液体区画に収容されている液体がリリースされ、反応キュベットの中に流れ、反応キュベット中で、該液体が計量素子中に収容されているサンプル液体に接触することが可能であることを特徴とするデバイス。
- 前記計量素子が、毛細管または流路の形態に設計されていることを特徴とする請求項1に記載のサンプル採取・計量デバイス。
- 前記液体区画中に収容されている少なくとも1種の液体が、緩衝溶液、希釈溶液または試薬溶液であることを特徴とする請求項1または2に記載のサンプル採取・計量デバイス。
- 前記液体区画が、引き剥がしまたは穴開け可能な液密且つ気密のホイルによって密閉されていることを特徴とする請求項1〜3のいずれかに記載のサンプル採取・計量デバイス。
- 前記支持体上に互いに離間していくつかの液体区画が存在し、該区画が特に同時または順次に開放可能であることを特徴とする請求項1〜4のいずれかに記載のサンプル採取・計量デバイス。
- 請求項1〜5のいずれかに記載のサンプル採取・計量デバイス、および反応キュベットを含む、サンプル液体中のアナライトを測定するための分析試験システム。
- 前記反応キュベットが、反応キュベット中のアナライトの測定を可能とするデバイスを含むことを特徴とする請求項6に記載の分析試験システム。
- 前記アナライトを測定するのに必要とされる特定の試薬液体が、サンプル採取・計量デバイスの支持体上の1つまたは複数の液体区画中に収容されていることを特徴とする請求項6または7に記載の分析試験システム。
- 前記アナライトを測定するのに必要とされる特定の試薬が、反応キュベット中に特にドライケミストリーの形態で収容されていることを特徴とする請求項6または7に記載の分析試験システム。
- 請求項6〜9のいずれかに記載の分析試験システムを用いてサンプル液体中のアナライトを測定するための方法であって、
a) 前記計量素子中に所定容量のサンプル液体が残るように、分析するサンプル液体に計量素子を接触させるステップ、
b) サンプル採取・計量デバイスを反応キュベット中に導入するステップ、
c) 前記支持体上の少なくとも1つの液体区画を開放して、この液体区画中に収容されている液体が反応キュベット中に流れ且つそこで前記計量素子中に含まれているサンプル液体と接触するようにし、サンプル液体を計量素子から反応キュベット中へ移送して反応混合物を形成するステップ、
e) 特に光学的な検出方法により、アナライトについて測定される特性量に基づきアナライトを測定するステップ、
を含む前記方法。 - 請求項10におけるステップc)とステップe)の間に、
d) アナライトの測定に必要な追加の試薬を加えるステップ、および/または反応混合物を混合するステップ、
をさらに含む請求項10に記載のサンプル液体中のアナライトを測定するための方法。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20050107359 EP1752755B1 (de) | 2005-08-10 | 2005-08-10 | Probenaufnahme- und-dosiervorrichtung mit integrierten Flüssigkeitskompartimenten |
Publications (2)
Publication Number | Publication Date |
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JP2007047170A JP2007047170A (ja) | 2007-02-22 |
JP4339879B2 true JP4339879B2 (ja) | 2009-10-07 |
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Application Number | Title | Priority Date | Filing Date |
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JP2006216736A Expired - Fee Related JP4339879B2 (ja) | 2005-08-10 | 2006-08-09 | 一体化した液体区画を有するサンプル採取・計量デバイス |
Country Status (4)
Country | Link |
---|---|
US (1) | US8303912B2 (ja) |
EP (1) | EP1752755B1 (ja) |
JP (1) | JP4339879B2 (ja) |
CA (1) | CA2555621C (ja) |
Families Citing this family (14)
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EP2209554B1 (de) * | 2007-11-13 | 2017-10-11 | F. Hoffmann-La Roche AG | Modulare sensorkassette |
US9562921B2 (en) * | 2008-03-25 | 2017-02-07 | Ortho-Clinical Diagnostics, Inc. | Immunodiagnostic test element having weakened foil layer |
CA2753886C (en) | 2009-03-02 | 2018-06-12 | Catholic Healthcare West | Diagnostic devices and methods of use |
WO2011043996A1 (en) * | 2009-10-06 | 2011-04-14 | Molecular Biometrics, Inc. | Verifying, via radio-frequency identification, completeness of a sample analysis in a chemical analytical procedure |
EP2529218A1 (en) | 2010-01-25 | 2012-12-05 | Cardiogenics Inc. | Self-metering system and testing device with casing and sliding member to cut-off and set sample volume |
GB201113990D0 (en) * | 2011-08-12 | 2011-09-28 | Molecular Vision Ltd | Flow control in a microfluidic device |
EP2868377B1 (en) * | 2013-10-31 | 2016-09-14 | Roche Diagniostics GmbH | Cartridge for stirring and dispensing a fluid, automatic analyzer and method of analyzing a biological sample |
US11433390B2 (en) * | 2017-12-07 | 2022-09-06 | Ion Llc | Methods and systems for a capillary device |
GB201812637D0 (en) * | 2018-08-03 | 2018-09-19 | Randox Laboratories Ltd | PCR cartridge |
CN110057652B (zh) * | 2019-04-25 | 2024-01-12 | 壹妙芯(厦门)科技有限公司 | 一种生物样品采集装置 |
DE102019118171A1 (de) * | 2019-07-04 | 2021-01-07 | Endress+Hauser Conducta Gmbh+Co. Kg | Verfahren zum Betreiben eines automatischen Analysegeräts und ein automatisches Analysegerät |
EP4182690A1 (en) * | 2020-07-20 | 2023-05-24 | Bio-Marketing-T, Ltd. (BMT) | Devices for lateral flow-based biological sample collection and diagnosis and methods of use thereof |
EP3944814B1 (de) * | 2020-07-30 | 2022-12-07 | Protzek Biotec GmbH | Vorrichtung zur entnahme einer flüssigkeitsprobe |
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-
2005
- 2005-08-10 EP EP20050107359 patent/EP1752755B1/de not_active Not-in-force
-
2006
- 2006-08-07 CA CA2555621A patent/CA2555621C/en not_active Expired - Fee Related
- 2006-08-09 JP JP2006216736A patent/JP4339879B2/ja not_active Expired - Fee Related
- 2006-08-10 US US11/502,564 patent/US8303912B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2555621A1 (en) | 2007-02-10 |
EP1752755A1 (de) | 2007-02-14 |
EP1752755B1 (de) | 2015-05-06 |
CA2555621C (en) | 2015-09-29 |
US20070036684A1 (en) | 2007-02-15 |
JP2007047170A (ja) | 2007-02-22 |
US8303912B2 (en) | 2012-11-06 |
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