JP4324673B2 - Cryotherapy device with Peltier module - Google Patents
Cryotherapy device with Peltier module Download PDFInfo
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- JP4324673B2 JP4324673B2 JP2004322309A JP2004322309A JP4324673B2 JP 4324673 B2 JP4324673 B2 JP 4324673B2 JP 2004322309 A JP2004322309 A JP 2004322309A JP 2004322309 A JP2004322309 A JP 2004322309A JP 4324673 B2 JP4324673 B2 JP 4324673B2
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本発明は、ペルチェモジュールを用いて患部を急速冷却および急速加熱の温度制御をすることによって皮膚癌または疣、痣、シミ等の病変部を壊死させ切除する凍結治療装置に関する。 The present invention relates to a cryotherapy device for ablating by necrotic skin cancer or warts, bruises, lesions of a stain by a temperature control of rapid cooling and rapid heating the affected area using a Peltier module.
冷凍療法は、皮膚の種々の良性、悪性腫瘍、色素性病変に対して皮膚科外来で日常的に行われている治療である。冷凍療法は、患者に与える苦痛が少ない、液体窒素があれば容易に行えるなどの利点があるが、その反面、現在行われている冷凍療法は、外科的切除、レーザー療法と異なり、凍結範囲を3次元的に制御することは不可能で、もっぱら術者の経験と感により調節されている。従って、しばしば、不必要に周囲の正常組織を冷凍し結果的に水疱を形成して患者に苦痛を与えたり、また、治療が不十分で目的とする腫瘍の治療が不十分であったりする。そのため、この治療範囲を制御できる凍結療法の有用性は極めて大きい。 Cryotherapy is a treatment routinely performed at a dermatological outpatient for various benign, malignant tumors, and pigmented lesions of the skin. Cryotherapy has the advantages of less pain to the patient and easy to do with liquid nitrogen, but on the other hand, cryotherapy currently being performed differs from surgical excision and laser therapy in that it has a freezing range. It is impossible to control in three dimensions, and it is adjusted exclusively by the experience and feeling of the surgeon. Therefore, often the surrounding normal tissue is unnecessarily frozen, resulting in blistering and suffering to the patient, or the treatment of the target tumor is inadequate due to insufficient treatment. Therefore, the usefulness of cryotherapy that can control this therapeutic range is extremely great.
かかる問題を解決するために、p型とn型の単体のペルチェ半導体と電極で構成されるペルチェ素子を用いた微小温度制御装置が開発され、皮膚科治療に用いられようとしている。例えば、特許文献1では、電極とヒートシンクを一体化することによりコンパクトな凍結治療装置が達成され、特許文献2では、ペルチェ素子を用いた凍結治療装置先端の形状を変えることによってより小さな領域の温度制御を可能としている。さらに、非特許文献1では、冷媒に固形二酸化炭素つまりドライアイスを用いて、ペルチェ素子を用いた凍結治療装置のヒートシンクを冷却している。 In order to solve such a problem, a micro temperature control device using a Peltier element composed of a single P-type and n-type Peltier semiconductor and an electrode has been developed and is being used for dermatological treatment. For example, in Patent Document 1, a compact cryotherapy apparatus is achieved by integrating an electrode and a heat sink, and in Patent Document 2, a temperature in a smaller region is achieved by changing the shape of the tip of the cryotherapy apparatus using a Peltier element. Control is possible. Further, in Non-Patent Document 1, the heat sink of a cryotherapy apparatus using a Peltier device is cooled by using solid carbon dioxide, that is, dry ice as a refrigerant.
かかる技術では、微小領域の冷却制御が可能となったが、温度制御部にペルチェ半導体を組み込んだペルチェ素子を使用しているために、装置の製作が難しく、製品の価格も高い欠点があった。また、冷媒にドライアイス等を用いる場合、皮膚科の医院でドライアイスを保存するための経費がかかる欠点があった。
これまでの凍結療法は、綿球にしみこませた液体窒素、液体窒素で冷やした金属、あるいは、液体窒素のスプレーなどの凍結範囲を制御できない治療方法であった。そのため、過度な冷凍、また、不十分な冷凍による治療がしばしばなされている。また、術者の毎の個人差、また、同一術者でも治療毎の凍結強度の変化が避けられない。ペルチェ素子を用いた凍結装置は、電流の強さ、冷却時間を制御することにより凍結範囲を制御することが可能であり、また、この2つのパラメーターを一定にすることにより術者間の差、治療毎の差も生じない治療が可能となる。また、ペルチェ素子を用いた凍結治療装置は微小領域の冷凍治療には適しているが、装置の構造と製作が困難で装置価格が高価になる問題があった。 Conventional cryotherapy has been a treatment method in which the freezing range such as liquid nitrogen soaked in a cotton ball, metal cooled with liquid nitrogen, or spray of liquid nitrogen cannot be controlled. Therefore, treatment by excessive freezing or insufficient freezing is often performed. In addition, individual differences for each operator, and changes in the freezing strength for each treatment are unavoidable even for the same operator. The freezing device using the Peltier device can control the freezing range by controlling the current intensity and the cooling time, and by making these two parameters constant, Treatment that does not cause a difference between treatments is possible. Although a cryotherapy apparatus using a Peltier element is suitable for cryotherapy of a micro area, there is a problem that the structure and manufacture of the apparatus are difficult and the apparatus price is expensive.
一方、皮膚科治療においては、直径5mm程度の領域以上の冷凍治療を行う必要があり、必ずしも、極微細領域の冷凍治療が必要でない。 On the other hand, in dermatological treatment, it is necessary to perform cryotherapy over an area having a diameter of about 5 mm, and it is not always necessary to perform cryotherapy in an extremely fine area.
本発明は、従来のペルチェ素子を用いる凍結治療装置を簡便化し、市販のペルチェモジュールを使用した実用性の高い皮膚治療を目的とする凍結治療装置を提供することを目的としている。 An object of the present invention is to simplify a cryotherapy apparatus using a conventional Peltier element, and to provide a cryotherapy apparatus aiming at highly practical skin treatment using a commercially available Peltier module.
本発明によれば、少なくとも2面を持ち、一方の面が凍結治療対象物に接触する先端チップと、少なくとも2面を持つペルチェモジュールと、前記ペルチェモジュールを低温に保つヒートシンクと、液体窒素を入れて前記ヒートシンクを冷却する内筒と、前記先端チップ、前記ペルチェモジュール、前記ヒートシンクおよび前記内筒を収納する気密性のある外筒と、前記ペルチェモジュールの通電電流を逆転制御するパワーモジュールと、前記ペルチェモジュールの温度を制御する温度制御コンピュータとを有し、前記先端チップの他方の面と前記ペルチェモジュールの一方の面とが接触し、前記ペルチェモジュールの他方の面と前記ヒートシンクとが接触するよう配置され、前記先端チップ、前記ペルチェモジュール、前記ヒートシンクおよび前記内筒と、前記外筒との隙間に二酸化炭素ガスが充填されていることを、特徴とする凍結治療装置が得られる。 According to the present invention, there is provided a tip having at least two surfaces, one surface of which contacts a cryotherapy object , a Peltier module having at least two surfaces, a heat sink for keeping the Peltier module at a low temperature, and liquid nitrogen. An inner cylinder that cools the heat sink, an airtight outer cylinder that houses the tip chip, the Peltier module, the heat sink and the inner cylinder, a power module that reversely controls an energization current of the Peltier module, A temperature control computer for controlling the temperature of the Peltier module , wherein the other surface of the tip chip contacts one surface of the Peltier module, and the other surface of the Peltier module contacts the heat sink. are arranged, the distal tip, the Peltier module, the heat sink Contact And fine the inner cylinder, that the carbon dioxide gas in the gap between the outer cylinder is filled, cryotherapy device is obtained characterized.
本発明によれば、前記温度制御コンピュータが前記パワーモジュールの通電電流逆転制御を複数回可逆的に制御できるよう構成したことを特徴とする凍結治療装置が得られる。 According to the present invention, it is possible to obtain a cryotherapy apparatus configured such that the temperature control computer can reversibly control energization current reversal control of the power module a plurality of times.
本発明によれば、前記温度制御コンピュータは、前記パワーモジュールの通電電流逆転制御を与えられたシークエンスに従って自動的に制御可能であることを、特徴とする凍結治療装置が得られる。 According to the present invention, it is possible to obtain a cryotherapy apparatus characterized in that the temperature control computer can automatically control the power module according to a given sequence of energization current reversal control.
本発明によれば、前記内筒は弾性を有するベローズまたはフレキシブルチューブから成り、前記内筒の弾性により前記ペルチェモジュールと前記先端チップとが圧着されていることを、特徴とする凍結治療装置が得られる。 According to the present invention, there is obtained a cryotherapy apparatus characterized in that the inner cylinder is made of an elastic bellows or a flexible tube, and the Peltier module and the tip are pressed by the elasticity of the inner cylinder. It is done.
本発明によれば、製作の難しいペルチェ素子に比べて製作が容易で安価な市販のペルチェモジュールを使用するので製作が容易で冷却面積が比較的大きい凍結治療装置が達成され、有効に皮膚の凍結治療を行うことが出来るという効果が得られる。また、凍結患部を解凍したり、再凍結を繰り返したりすることにより、標的病変における細胞壊死率を向上させることが可能となる。 According to the present invention, since a commercially available Peltier module that is easier to manufacture and cheaper than a Peltier element that is difficult to manufacture is used, a cryotherapy device that is easy to manufacture and has a relatively large cooling area is achieved, and effective skin freezing is achieved. An effect that treatment can be performed is obtained. Moreover, it becomes possible to improve the cell necrosis rate in the target lesion by thawing the frozen affected part or repeating refreezing.
また、ヒートシンクを液体窒素で冷却することによって、ペルチェモジュールの冷却速度を向上させるとともに、二重容器隙間部に充填させた二酸化炭素を昇華させ真空断熱効果を得ることが出来、断熱厚さを減少できる効果がある。 In addition, by cooling the heat sink with liquid nitrogen, the cooling rate of the Peltier module can be improved, and the carbon dioxide filled in the double container gap can be sublimated to obtain a vacuum insulation effect, reducing the insulation thickness. There is an effect that can be done.
以下、本発明の実施の形態について図面を参照しながら説明する。
図1は本発明に関し、通常断熱材を用いた凍結治療装置の概略構成を示す図である。図1を参照すると、ペルチェモジュール1が熱伝導生の良いアルミニウムや銅などで製作される先端チップ2と熱伝導の良い金属で製作されたヒートシンク5に挟まれている。ヒートシンク5は、液体窒素9を収納する内筒6にハンダ等で接着されている。ペルチェモジュール1と先端チップ2やヒートシンク5はシリコーンゴム接着剤や熱伝導性グリースなどで接着され、熱応力がかからない構造となっている。
Hereinafter, embodiments of the present invention will be described with reference to the drawings.
Figure 1 relates to the present invention, it is a diagram showing a schematic configuration of a cryotherapy device using a conventional insulation. Referring to FIG. 1, a Peltier module 1 is sandwiched between a tip chip 2 made of aluminum, copper or the like having good heat conduction and a heat sink 5 made of metal having good heat conduction. The heat sink 5 is bonded to the inner cylinder 6 containing the liquid nitrogen 9 with solder or the like. The Peltier module 1, the tip chip 2, and the heat sink 5 are bonded with a silicone rubber adhesive, heat conductive grease, or the like, and have a structure in which no thermal stress is applied.
ペルチェモジュール1は一辺が6mmから50mmの正方形または長方形であり、先端チップ2の皮膚と接触する被温度制御面3は直径3mmから50mmである。前記先端チップ2は少なくとも2面(第11面および第12面、不図示)を持ち、前記被温度制御面3は第11面に相当し、凍結治療対象物と接触する。またペルチェモジュール1も少なくとも2面(第21面および第22面、不図示)を持ち、前記第12面と前記第21面が接触する。そして、前記22面と前記ヒートシンク5とが接触する構造となっている。 The Peltier module 1 is a square or rectangle having a side of 6 mm to 50 mm, and the temperature-controlled surface 3 that contacts the skin of the tip 2 has a diameter of 3 mm to 50 mm. The tip 2 has at least two surfaces (an eleventh surface and a twelfth surface, not shown), and the temperature-controlled surface 3 corresponds to an eleventh surface and is in contact with a cryotherapy object. The Peltier module 1 also has at least two surfaces (a 21st surface and a 22nd surface, not shown), and the 12th surface and the 21st surface are in contact with each other. The 22 surfaces and the heat sink 5 are in contact with each other.
これらの装置は金属またはプラスチック製の外筒7に覆われており、内筒6と外筒7の間を発泡ポリウレタンや発泡ポリスチレン等の断熱材10が充填されている。その断熱層厚さは、大略10mmから30mm程度である。 These apparatuses are covered with an outer cylinder 7 made of metal or plastic, and a space between the inner cylinder 6 and the outer cylinder 7 is filled with a heat insulating material 10 such as polyurethane foam or polystyrene foam. The thickness of the heat insulating layer is about 10 mm to 30 mm.
先端チップ2の被温度制御面3近傍に温度センサー4が装着され、温度制御コンピュータ12ならびにパワーモジュール13を介してペルチェモジュール1の温度制御を行う。 A temperature sensor 4 is mounted in the vicinity of the temperature control surface 3 of the tip 2 and performs temperature control of the Peltier module 1 via the temperature control computer 12 and the power module 13.
まず内筒6に液体窒素9を入れてヒートシンク5を冷却するとき、ペルチェモジュール1は加熱モードで作動し、先端チップ2の温度を大略体温程度に保っている。凍結治療装置を皮膚腫瘍、色素性病変の患部に接触させてからペルチェモジュール1の電流を逆転させ急速冷却を行う。その時、温度センサー4の温度をモニターすることによって、皮膚組織の過冷却解除を関知し患部の組織の凍結開始をモニターし、冷却時間とペルチェモジュール1の通電電流を制御することにより、患部の凍結深さを制御し、皮下組織16などの健康部位の凍結を防止する。 First, when liquid nitrogen 9 is put in the inner cylinder 6 to cool the heat sink 5, the Peltier module 1 operates in the heating mode, and the temperature of the tip 2 is kept at about body temperature. After the cryotherapy apparatus is brought into contact with the affected area of the skin tumor or pigmented lesion, the current of the Peltier module 1 is reversed to perform rapid cooling. At that time, the temperature of the temperature sensor 4 is monitored to detect the release of supercooling of the skin tissue to monitor the start of freezing of the affected tissue, and by controlling the cooling time and the energization current of the Peltier module 1, The depth is controlled to prevent freezing of healthy sites such as the subcutaneous tissue 16 .
さらに、ペルチェモジュール1の電流を逆転することにより、凍結患部を解凍し、患部の細胞壊死率を高めることも可能である。この制御を与えられたシークエンスに従って自動的に制御することも可能である。温度制御コンピュータ12とパワーモジュール13は一体化して装置に組み込むことも可能である。 Further, by reversing the current of the Peltier module 1, it is possible to thaw the frozen affected area and increase the cell necrosis rate of the affected area. It is also possible to automatically control this control according to a given sequence. The temperature control computer 12 and the power module 13 can be integrated into the apparatus.
また、本発明に関し、温度制御法は、ペルチェモジュールを用いる本凍結治療装置に限定されるものではなく、ペルチェ素子を用いた温度制御法にも適用できる。本発明に関し、ペルチェ素子を用いた凍結治療装置は図1あるいは図2においてペルチェモジュール4をペルチェ素子に置き代えたもので特に図示しない。ペルチェ素子を用いた凍結治療装置においても前記先端チップ2は少なくとも2面(第311面および第312面、不図示)を持ち、前記被温度制御面3は第311面に相当し、凍結治療対象物と接触する。またペルチェ素子1も少なくとも2面(第321面および第322面、不図示)を持ち、前記第312面と前記第321面が接触する。そして、前記322面と前記ヒートシンク5とが接触する構造となっている。 Also relates to the present invention, the temperature control method is not limited to the cryotherapy device using a Peltier module can also be applied to a temperature control method using a Peltier element. Related to the present invention, cryotherapy device using the Peltier element is not particularly illustrated in that replaced the Peltier module 4 to the Peltier element 1 or 2. Also in a cryotherapy apparatus using a Peltier element, the tip 2 has at least two surfaces (a 311th surface and a 312th surface, not shown), the temperature-controlled surface 3 corresponds to a 311 surface, and is a cryotherapy object. Contact with objects. The Peltier element 1 also has at least two surfaces (a 321st surface and a 322th surface, not shown), and the 312th surface and the 321st surface are in contact with each other. And it has the structure where the said 322 surface and the said heat sink 5 contact.
図2は、本発明の実施の形態による、二酸化炭素充填層を用いた凍結治療装置の概略構成を示す図である。図2を参照すると、内筒17はベローズやフレキブルチューブで製作され、ヒートシンク5とハンダ等で接合されている。装置1,2,5,17は気密性のある外筒18に収納され、その隙間に大略大気圧程度の二酸化炭素ガスが充填されている。内筒17と外筒18はOリング20を介して接合され、内筒17と外筒18の隙間の気密を保っている。温度センサー4やペルチェモジュール1の導線は気密コネクタ21を介して接続されている。本発明の形態によると、フレキシブルチューブの弾性で、ペルチェモジュール1と先端チップ2を圧着しているため、液体窒素9を入れたときに容器が温度収縮してもペルチェモジュール1に適当な圧着力が作用する利点がある。 FIG. 2 is a diagram showing a schematic configuration of a cryotherapy apparatus using a carbon dioxide filled layer according to an embodiment of the present invention. Referring to FIG. 2, the inner cylinder 17 is made of a bellows or a flexible tube, and is joined to the heat sink 5 with solder or the like. The devices 1, 2, 5, and 17 are housed in an airtight outer cylinder 18, and the gap is filled with carbon dioxide gas at about atmospheric pressure. The inner cylinder 17 and the outer cylinder 18 are joined via an O-ring 20 to keep the gap between the inner cylinder 17 and the outer cylinder 18 airtight. Conductive wires of the temperature sensor 4 and the Peltier module 1 are connected via an airtight connector 21. According to the embodiment of the present invention, since the Peltier module 1 and the tip chip 2 are pressure-bonded by the elasticity of the flexible tube, an appropriate pressure-bonding force is applied to the Peltier module 1 even when the container shrinks when liquid nitrogen 9 is introduced. Has the advantage of acting.
本装置が作動していないとき、二酸化炭素19は単なるガス層として熱を伝えるが、装置動作時に液体窒素9を内筒17に充填すると内筒17が極低温になり二酸化炭素19がドライアイスとして内筒17外壁に昇華付着する。この作用によって、隙間が真空状態となり、高性能断熱が達成される。 When the apparatus is not in operation, the carbon dioxide 19 conducts heat as a simple gas layer. However, when the apparatus is in operation, if the inner cylinder 17 is filled with liquid nitrogen 9, the inner cylinder 17 becomes extremely cold and the carbon dioxide 19 becomes dry ice. Sublimation adheres to the outer wall of the inner cylinder 17. By this action, the gap is in a vacuum state, and high performance heat insulation is achieved.
本発明の作用によって、薄い断熱層厚さで液体窒素9の断熱が可能となるので、装置がコンパクトになり医師の治療がしやすくなる。従来の真空断熱を使った極低温プローブは、高度な真空容器にしたり、常に真空ポンプで吸引したりして使用していた。本発明の断熱層によれば、装置を使用しないときは、この隙間は大気圧となっているので、高度な真空容器が必要とならない。この、真空断熱機構は、液体窒素9等の極低温冷媒を使用する全ての真空断熱層に適用されるもので、本凍結治療装置に限定されるものではない。 The action of the present invention makes it possible to insulate the liquid nitrogen 9 with a thin heat insulating layer thickness, so that the apparatus is compact and easy for a doctor to treat. Conventional cryogenic probes using vacuum insulation have been used in advanced vacuum vessels or always with a vacuum pump. According to the heat-insulating layer of the present invention, when the apparatus is not used, this gap is at atmospheric pressure, so that an advanced vacuum vessel is not necessary. This vacuum heat insulation mechanism is applied to all vacuum heat insulation layers using a cryogenic refrigerant such as liquid nitrogen 9 and is not limited to the present cryotherapy apparatus.
本発明に係るペルチェモジュールによる凍結治療装置は、各種皮膚腫瘍、色素性病変等冷凍凍結削除や、その他の人体部位の部分凍結や加熱を行う医療の様々な分野に広く適用できる。 The cryotherapy apparatus using the Peltier module according to the present invention can be widely applied to various fields of medical treatment in which various types of skin tumors, pigmented lesions and the like are frozen and deleted, and other parts of the human body are partially frozen and heated.
特に、皮膚の疾患部位を、健常部位を切除することなく正確に取り除くことが出来る。また、冷凍治療は治癒後の組織快復が良好なので医療および美容外科等に広く用いることが出来る。 In particular, the diseased part of the skin can be accurately removed without excising the healthy part. In addition, the freezing treatment can be widely used for medical treatment and cosmetic surgery because the tissue recovery after healing is good.
1 ペルチェモジュール
2 先端チップ
3 被温度制御面
4 温度センサー
5 ヒートシンク
6 内筒
7 外筒
8 スペーサー
9 液体窒素
10 断熱材
11 ふた
12 温度制御コンピュータ
13 パワーモジュール
14 表皮
15 真皮
16 皮下組織
17 フレキシブルチューブ製内筒
18 気密外筒
20 Oリング
21 気密コネクタ
1 Peltier module 2 Tip chip 3 Temperature control surface
4 temperature sensor 5 heat sink 6 inner cylinder 7 outer cylinder 8 spacer 9 liquid nitrogen 10 heat insulating material 11 lid 12 temperature control computer 13 power module 14 epidermis 15 dermis 16 subcutaneous tissue 17 flexible tube inner cylinder 18 airtight outer cylinder 20 O-ring 21 airtight connector
Claims (4)
少なくとも2面を持つペルチェモジュールと、
前記ペルチェモジュールを低温に保つヒートシンクと、
液体窒素を入れて前記ヒートシンクを冷却する内筒と、
前記先端チップ、前記ペルチェモジュール、前記ヒートシンクおよび前記内筒を収納する気密性のある外筒と、
前記ペルチェモジュールの通電電流を逆転制御するパワーモジュールと、
前記ペルチェモジュールの温度を制御する温度制御コンピュータとを有し、
前記先端チップの他方の面と前記ペルチェモジュールの一方の面とが接触し、前記ペルチェモジュールの他方の面と前記ヒートシンクとが接触するよう配置され、前記先端チップ、前記ペルチェモジュール、前記ヒートシンクおよび前記内筒と、前記外筒との隙間に二酸化炭素ガスが充填されていることを、
特徴とする凍結治療装置。 A tip having at least two surfaces, one surface contacting the cryotherapy object;
A Peltier module with at least two sides ;
A heat sink for keeping the Peltier module at a low temperature;
An inner cylinder for cooling the heat sink with liquid nitrogen;
An airtight outer cylinder that houses the tip chip, the Peltier module, the heat sink, and the inner cylinder;
A power module that reversely controls the energization current of the Peltier module;
A temperature control computer for controlling the temperature of the Peltier module ;
The other surface of the tip chip and one surface of the Peltier module are in contact with each other, and the other surface of the Peltier module is in contact with the heat sink, and the tip chip, the Peltier module, the heat sink, and the That carbon dioxide gas is filled in the gap between the inner cylinder and the outer cylinder,
A cryotherapy device characterized.
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