JP4197158B2 - 天然に発生する生物学的に誘導されている材料による装置 - Google Patents
天然に発生する生物学的に誘導されている材料による装置 Download PDFInfo
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- JP4197158B2 JP4197158B2 JP2003513448A JP2003513448A JP4197158B2 JP 4197158 B2 JP4197158 B2 JP 4197158B2 JP 2003513448 A JP2003513448 A JP 2003513448A JP 2003513448 A JP2003513448 A JP 2003513448A JP 4197158 B2 JP4197158 B2 JP 4197158B2
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- bone
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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Description
同時係属の「メニスカス・リジェネレーション・デバイス・アンド・メソッド(Meniscus Regeneration Device and Method)」を発明の名称とする米国特許出願第10/195,794号(代理人明細書番号第265280−71141号,DEP−745)、「カーテイレイジ・リペア・アパレイタス・アンド・メソッド(Cartilage Repair Apparatus and Method)」を発明の名称とする米国特許出願第10/195,347号(代理人明細書番号第265280−71143号,DEP−749)、「ユニタリー・サージカル・デバイス・アンド・メソッド(Unitary Surgical Device and Method)」を発明の名称とする米国特許出願第10/195,344号(代理人明細書番号DEP−750)、「ハイブリッド・バイオロジック/シンセチック・ポーラス・エクストラセルラー・マトリクス・スキャフォルド(Hybrid Biologic/Synthetic Porous Extracellular Matrix Scaffolds)」を発明の名称とする米国特許出願第10/195,341号(代理人明細書番号第265280−71144号,DEP−751)、「カーテイレイジ・リペア・アンド・リジェネレーション・デバイス・アンド・メソッド(Cartilage Repair and Regeneration Device and Method)」を発明の名称とする米国特許出願第10/195,606号(代理人明細書番号第265280−71145号,DEP−752)、「ポーラス・エクストラセルラー・マトリクス・スキャフォルド・アンド・メソッド(Porous Extracellular Matrix Scaffold and Method)」を発明の名称とする米国特許出願第10/195,354号(代理人明細書番号第265280−71146号,DEP−747)、「カーテイレイジ・リペア・アンド・リジェネレーション・スキャフォルド・アンド・メソッド(Cartilage Repair and Regeneration Scaffolds and Methods)」を発明の名称とする米国特許出願第10/195,334号(代理人明細書番号第265280−71180号,DEP−763)、および「ポーラス・デリバリー・スキャフォルド・アンド・メソッド(Porous Delivery Scaffold and Method)」を発明の名称とする米国特許出願第10/195,633号(代理人明細書番号第265280−71207号,DEP−762)に対してクロス・リファレンスが行なわれており、これらのそれぞれは本特許出願と同一の譲受人に譲渡されており、これらのそれぞれは本特許出願と同時に出願されていて、これらのそれぞれは本明細書に参考文献として含まれる。また、2002年6月14日に出願されている「ハイブリッド・バイオロジック−シンセチック・バイオアブソーバブル・スキャフォルズ(Hybrid Biologic-Synthetic Bioabsorbable Scaffolds)」を発明の名称とする米国特許出願第10/172,347号に対してもクロス・リファレンスが行なわれている。
本発明は整形外科的な組織を結合、修復または再生するための装置に関連しており、特に、構造的な剛性および硬度を有するように硬化または処理されている天然に発生する細胞外基質により作成されている上記のような装置に関連している。
図1乃至図3は軟骨、靭帯、腱等のような軟質組織を骨に結合するための外科装置10を示しており、この装置は軟質組織に係合するように構成されているヘッド部分12および骨に係合して結合するように構成されている本体部分14を有している。これらのヘッド部分12および本体部分14は例示的にモノリシック型であり、骨に対する結合を容易にするために剛性で硬質になるように硬化されている天然に発生する細胞外基質により形成されている。本体部分14は骨の中への侵入を容易にするためにヘッド部分12から先端側に尖った端部16を有している。なお、装置10を製造するECM材料が当該装置10を骨組織の中に駆動可能にするように硬質化および増強されていることが認識されると考える。このように硬度および強靭さを伴う尖った端部16は骨の中への挿入を容易にする。上記装置10の保持能力または把持能力を高めるために、本体部分14はその尖った端部16とヘッド部分12との間において半径方向に沿って外側に延出している突起部分または突起状の部分20,22を備えており、これらは例示的にヘッド部分に向かってそれぞれ傾斜している。さらに、これらの部分20,22は本体部分14における半径方向に対向している平坦部分24,26を加工または形成することにより例示的に定められている。図3において最良に示されているように、各平坦部分24は突起部分20におけるそれぞれ半径方向に対向している側面において形成されており、各平坦部分26は突起部分22におけるそれぞれ半径方向に対向している側面において形成されている。
12 ヘッド部分
14 本体部分
16 尖った端部
20,22 突起部分
24,26 平坦部分
Claims (26)
- 生体再造形可能な膠原性組織基質を備えている整形外科装置であって、
当該再造形可能な膠原性組織基質が天然に発生する細胞外基質の素材を粉砕し固めた細胞外基質材料を含み、
当該細胞外基質材料が硬化されており、
当該膠原性組織基質が、骨に対する結合を容易にするためにロックウェルDスケールにおいて30HRDよりも大きい硬度を有している、
整形外科装置。 - 前記生体再造形可能な膠原性組織基質がロックウェルDスケールにおいて少なくとも60HRDの硬度を有している請求項1に記載の整形外科装置。
- 前記生体再造形可能な膠原性組織基質がロックウェルDスケールにおいて少なくとも70HRDの硬度を有している請求項1に記載の整形外科装置。
- 前記生体再造形可能な膠原性組織基質が0.5g/mLよりも高い密度を有している請求項1〜3のいずれかに記載の整形外科装置。
- 前記生体再造形可能な膠原性組織基質が0.7g/mLよりも高い密度を有している請求項1〜3のいずれかに記載の整形外科装置。
- 前記装置が、
生体活性物質、
生物学的に誘導されている物質、
生物学的な潤滑剤、
生体相容性のポリマー、
生体相容性の無機材料、
種々の細胞、
種々の軟骨細胞、
種々の骨細胞、
種々の滑膜細胞、
前記ロックウェルDスケールにおいて70HRDよりも低い硬度を有している天然に発生する生体再造形可能な膠原性組織基質、および、
0.7g/mLよりも低い密度を有している天然に発生する生体再造形可能な膠原性組織基質、から成る群から選択される材料を伴う複合体を備えている請求項1〜5のいずれかに記載の整形外科装置。 - 前記装置が、
不織状の天然に発生する生体再造形可能な膠原性組織基質を含むマット、
編み組み状の天然に発生する生体再造形可能な膠原性組織基質、
生体再造形可能な膠原性組織基質を含む発泡体、
生体再造形可能な膠原性組織基質を含む積層体、
生体再造形可能な膠原性組織基質を含む織り状の材料、
生物学的に吸収可能なポリマーの積層体、
生物学的に吸収可能なポリマーの発泡体、
生物学的に吸収可能なポリマーの織り状の材料、および
不織状の生物学的に吸収可能なポリマーを含むマット、から成る群から選択される材料を伴う複合体を備えている請求項1〜6のいずれかに記載の整形外科装置。 - 前記装置が、モノリシック型のヘッド部分および本体部分を備えている整形外科用の鋲を備えている請求項1〜7のいずれかに記載の整形外科装置。
- 前記装置が軟質組織を骨に結合するための固定具を備え、当該装置が軟質組織に係合するように構成されている部分および骨に係合するように構成されている一体の部分を備えている請求項1〜7のいずれかに記載の整形外科装置。
- 前記装置が、少なくとも2個の離間している突起部分を有する固定具を備え、前記各突起部分が鋭利化した先端部および基端部を有しており、前記装置がさらに前記突起部分の各基端部を接続する部材を備えている請求項1〜7のいずれかに記載の整形外科装置。
- 前記装置が、少なくとも2個の離間している突起部分およびこれら2個の突起部分を接続している一体の部材を備えている固定具を備えている請求項1〜7のいずれかに記載の整形外科装置。
- 前記装置が、骨の中に形成されている開口部の中に骨プラグ部材を固定するための固定具を備え、前記請求項1に係る生体再造形可能な膠原性組織基質が前記骨プラグ部材と骨との間にくさび状に詰め込まれるように構成されている請求項1〜7のいずれかに記載の整形外科装置。
- 前記装置が、内部に通路を有している本体部分を備えている固定具を備え、前記本体部分が圧縮条件下において内側につぶれるように構成されている請求項1〜7のいずれかに記載の整形外科装置。
- 前記装置が、外殻部分および当該外殻部分により囲まれている内側部分を備えており、前記外殻部分が前記ロックウェルDスケールにおいて50HRDよりも高い硬度を有しており、前記内側部分が前記ロックウェルDスケールにおいて70HRDよりも低い硬度を有している請求項1〜7のいずれかに記載の整形外科装置。
- 前記装置が、頂上部分および基底部分を定めるために角度的に分離している上方パネルおよび下方パネルを有しているくさび形の本体部分を備え、前記各パネルが前記請求項1に係る生体再造形可能な膠原性組織基質により形成されている請求項1〜7のいずれかに記載の整形外科装置。
- 前記本体部分が前記骨の中への侵入を容易にするために前記ヘッド部分から先端側において尖った端部を有している請求項8に記載の装置。
- 前記尖った端部と前記ヘッド部分の間における前記本体部分が半径方向に沿って外側に延出している突起部分を伴って形成されている請求項16に記載の装置。
- 前記突起部分が前記ヘッド部分に向かって傾斜している請求項17に記載の装置。
- 前記本体部分が当該本体部分に沿って延在している直径方向に対向している平坦部分を備えており、これらの平坦部分が概ね平行である請求項15〜18のいずれかに記載の装置。
- 前記装置が前記ヘッド部分および本体部分を定めるために前記硬化した細胞外基質材料を機械加工することにより形成されている請求項16〜19のいずれかに記載の装置。
- 2個の接続した部分を備えており、各部分が前記請求項1に係る生体再造形可能な膠原性組織基質を含み、各部分が硬度および密度を有しており、一方の部分がロックウェルDスケールにおいて50HRD以上の硬度および0.5g/mLよりも高い密度を有しており、別の部分が異なる硬度および異なる密度を有している請求項1〜20のいずれかに記載の整形外科装置。
- 前記装置が2個の接続した部分を備えており、各部分が前記細胞外基質材料を含み、各部分が硬度および密度を有しており、一方の部分が前記装置を本来の組織に固定するように構成されていてロックウェルDスケールにおいて50HRD以上の硬度および0.5g/mLよりも高い密度を有しており、別の部分が異なる構成、異なる硬度および異なる密度を有している請求項1〜20のいずれかに記載の整形外科装置。
- 生体再造形可能な膠原性組織基質を備えている整形外科装置であって、
当該再造形可能な膠原性組織基質が天然に発生する細胞外基質の素材であり、
当該細胞外基質が硬化されており、
当該膠原性組織基質が、骨に対する結合を容易にするためにロックウェルDスケールにおいて30HRDよりも大きい硬度を有しており、
更に、
前記装置が軟骨性の表面における断裂部分を修復するように構成されており、当該装置が前記断裂部分の中に配置されて当該断裂部分に沿って延在するための本体部分を形成するために一体に貼り合わされている前記天然に発生する細胞外基質の複数の部材片、および前記本体部分を断裂部分の中に固定するために当該本体部分に連結している1個以上の鋲を備えており、これらの鋲のそれぞれが前記天然に発生する細胞外基質により形成されている、整形外科装置。 - 前記細胞外基質材料が硬質および剛性になるように硬化されているSISである請求項1〜22のいずれかに記載の装置。
- 前記装置が2個の離間している突起部分を備えており、各突起部分が鋭利化されている先端部および基端部を有しており、さらに前記装置が各突起部分の基端部を接続している部材を備えており、前記突起部分が前記細胞外基質材料により形成されている請求項1〜22のいずれかに記載の装置。
- 生体再造形可能な膠原性組織基質を備えている整形外科装置であって、
当該再造形可能な膠原性組織基質が天然に発生する細胞外基質の素材であり、
当該細胞外基質が硬化されており、
当該膠原性組織基質が、骨に対する結合を容易にするためにロックウェルDスケールにおいて30HRDよりも大きい硬度を有しており、
更に、
前記装置が2個の離間している突起部分を備えており、各突起部分が鋭利化されている先端部および基端部を有しており、さらに前記装置が各突起部分の基端部を接続している部材を備えており、
前記接続部材および前記突起部分が剛性の硬質化したシート状の本体部分を形成するために一体に貼り合わされて硬化されている天然に発生する細胞外基質の複数の層により形成されており、前記突起部分および前記接続部材が前記本体部分から切り出されている、整形外科装置。
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- 2002-07-15 US US10/195,719 patent/US20030032961A1/en not_active Abandoned
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- 2002-07-15 JP JP2003513448A patent/JP4197158B2/ja not_active Expired - Fee Related
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WO2003007839A2 (en) | 2003-01-30 |
AU2002322567B2 (en) | 2007-09-06 |
US8337537B2 (en) | 2012-12-25 |
US20030032961A1 (en) | 2003-02-13 |
JP2004535250A (ja) | 2004-11-25 |
US20040220574A1 (en) | 2004-11-04 |
EP1416866A4 (en) | 2007-04-18 |
WO2003007839A3 (en) | 2003-04-24 |
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