JP4095028B2 - 生物学的標本を作製するためのカセット装置及び方法 - Google Patents
生物学的標本を作製するためのカセット装置及び方法 Download PDFInfo
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- JP4095028B2 JP4095028B2 JP2003536720A JP2003536720A JP4095028B2 JP 4095028 B2 JP4095028 B2 JP 4095028B2 JP 2003536720 A JP2003536720 A JP 2003536720A JP 2003536720 A JP2003536720 A JP 2003536720A JP 4095028 B2 JP4095028 B2 JP 4095028B2
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- specimen
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- biological specimen
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- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 239000000463 material Substances 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 239000013013 elastic material Substances 0.000 claims 4
- 210000004177 elastic tissue Anatomy 0.000 claims 2
- 239000001993 wax Substances 0.000 description 12
- 239000012188 paraffin wax Substances 0.000 description 8
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
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- 229940057995 liquid paraffin Drugs 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
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- 238000012864 cross contamination Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
- G01N2001/2873—Cutting or cleaving
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Description
Claims (7)
- 生物学的標本(20)が乾燥され、ワックスに埋め込まれ、任意にスライスされ、該生物学的標本(20)が、標本作製過程の少なくとも一部の間、蓋(2)によって閉じられる容器(1)に入れられている、生物学的標本(20)を作製する方法において、前記生物学的標本(20)が、バネ要素、繊維、開いたセルを有する弾性材料、及び開いた孔を有する弾性材料よりなる群から選択される少なくとも1つの保持要素(6)によって保持されており、ここで、該保持要素(6)からの力は前記生物学的標本(20)との接触面にかけられ、前記生物学的標本(20)を埋め込むためのワックスが前記容器(1)と蓋(2)とに満たされ、ワックスが硬化した後であってスライス操作の前に、容器(1)が蓋(2)及び埋め込まれた生物学的標本(20)から除去されることを特徴とする方法。
- 前記蓋(2)と保持要素(6)とによって生物学的標本(20)が閉じられる前に、前記生物学的標本(20)が前記容器(1)に載置され、続くスライス操作に適合するように配置されることを特徴とする請求項1に記載の方法。
- 前記標本が前記容器(1)内に閉じ入れられる前に、前記生物学的標本(20)が前記蓋(2)又は前記保持要素(6)の上に載置され、続くスライス操作に適合するように配置されることを特徴とする請求項1に記載の方法。
- 生物学的標本(20)を作製するのに使用される容器(1)及び蓋(2)の装置において、好ましくは、前記容器(1)中に押し下げられるように設計されている、バネ要素、繊維、開いたセルを有する弾性材料、及び開いた孔を有する弾性材料よりなる群から選択される少なくとも1つの保持要素(6)が前記蓋(2)と前記標本(20)との間に配設され、該保持要素(6)によって維持される保持力が前記生物学的標本(20)の接触面にかかることを特徴とする装置。
- 前記保持要素(6)が、前記蓋(2)の前記容器(1)に面する側に接続されていることを特徴とする、請求項4に記載の装置。
- 前記蓋(2)の前記容器(1)側の面(4)に孔が設けられていることを特徴とする、請求項4又は5に記載の装置。
- 前記容器(1)の内底に開いたセルを有する材料( 30 )が備えられていることを特徴とする請求項4〜6のいずれか一項に記載の装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO20015130A NO315063B1 (no) | 2001-10-19 | 2001-10-19 | Anordning og fremgangsmåte ved kassett for preparering av biologiske pröver |
PCT/NO2002/000366 WO2003034033A1 (en) | 2001-10-19 | 2002-10-10 | Arrangement and method for a cassette for preparation of biological specimens |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005505776A JP2005505776A (ja) | 2005-02-24 |
JP4095028B2 true JP4095028B2 (ja) | 2008-06-04 |
Family
ID=19912934
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003536720A Expired - Fee Related JP4095028B2 (ja) | 2001-10-19 | 2002-10-10 | 生物学的標本を作製するためのカセット装置及び方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US7547542B2 (ja) |
EP (1) | EP1436587A1 (ja) |
JP (1) | JP4095028B2 (ja) |
CA (1) | CA2462984C (ja) |
NO (1) | NO315063B1 (ja) |
WO (1) | WO2003034033A1 (ja) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7179424B2 (en) * | 2002-09-26 | 2007-02-20 | Biopath Automation, L.L.C. | Cassette for handling and holding tissue samples during processing, embedding and microtome procedures, and methods therefor |
ES2401865T3 (es) | 2002-09-26 | 2013-04-25 | Biopath Automation, L.L.C. | Aparato y procedimientos para la manipulación automatizada e incorporación de muestras de tejido |
WO2004028693A1 (en) | 2002-09-26 | 2004-04-08 | Biopath Automation, L.L.C. | Cassette and embedding assembly, staging devices, and methods for handling tissue samples |
JP4667061B2 (ja) * | 2005-02-14 | 2011-04-06 | 村角工業株式会社 | 医療検査用検体薄片の製造方法 |
US20070116612A1 (en) * | 2005-11-02 | 2007-05-24 | Biopath Automation, L.L.C. | Prefix tissue cassette |
WO2007074769A1 (ja) * | 2005-12-27 | 2007-07-05 | Kyoto University | 生物組織固定・包埋・薄切用カセット及びその操作方法 |
JP4797167B2 (ja) * | 2006-01-18 | 2011-10-19 | 国立大学法人 東京大学 | 包埋用カセット |
US20070253870A1 (en) * | 2006-05-01 | 2007-11-01 | Operon Biotechnologies, Inc. | Specimen tube holder and shipping container |
ES2788002T3 (es) * | 2006-12-12 | 2020-10-20 | Biopath Automation Llc | Soporte de biopsia con material celular resiliente seccionable |
JP5112705B2 (ja) * | 2007-01-25 | 2013-01-09 | 村角工業株式会社 | 病理組織検査標本作成用の包埋トレイ |
US7951345B2 (en) * | 2007-06-01 | 2011-05-31 | Lary Research & Development, Llc | Useful specimen transport apparatus with integral capability to allow three dimensional x-ray images |
JP2009156791A (ja) * | 2007-12-27 | 2009-07-16 | Kankyo Kiki:Kk | ホルマリン吸収用シート |
ES2746196T3 (es) * | 2009-01-22 | 2020-03-05 | Biopath Automation Llc | Soporte de biopsia seccionable de micrótomo para orientar muestras de tejido |
US8308127B1 (en) * | 2010-06-07 | 2012-11-13 | Harris Ryan M | Faux ice tray system |
GB2485240A (en) * | 2010-11-08 | 2012-05-09 | Thermo Shandon Ltd | Waste liquid wax tray |
US9546937B2 (en) | 2012-01-26 | 2017-01-17 | Richard-Allan Scientific Company | Tissue cassette assembly |
CN105784457B (zh) * | 2016-03-21 | 2018-04-20 | 中国医科大学附属第一医院 | 低温组织样本包埋储存*** |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2878848A (en) * | 1953-07-27 | 1959-03-24 | Republic Molding Corp | Containers |
GB1230913A (ja) | 1968-05-01 | 1971-05-05 | ||
US3733768A (en) * | 1971-02-12 | 1973-05-22 | B Carls | Storage of histology specimens |
US3982862A (en) | 1975-04-03 | 1976-09-28 | Pickett John E P | Two-part composite device for histologic tissue processing and embedding |
US4569647A (en) * | 1983-09-16 | 1986-02-11 | Pelam, Inc. | Apparatus for preparing and embedding tissue samples for histological examination |
US4715545A (en) * | 1986-02-13 | 1987-12-29 | Sage Products, Inc. | Tissue grinding and transport system and method |
GB2189596B (en) * | 1986-04-16 | 1990-08-01 | Pa Consulting Services | Methods of and apparatus for preparing tissue specimens |
US5129517A (en) * | 1988-11-03 | 1992-07-14 | Oscar Mayer Foods Corporation | Food package containing a reclosable means |
JPH0363841A (ja) | 1989-08-02 | 1991-03-19 | Shizuoka Nippon Denki Software Kk | 分散集中管理システムでの障害の監視方式 |
US5269671A (en) * | 1992-02-11 | 1993-12-14 | Mccormick James B | Apparatus for embedding tissue samples |
JP3049537B2 (ja) | 1995-02-03 | 2000-06-05 | 悌二 竹崎 | 生検試料の定着支持方法とその定着支持剤及び包埋カセット |
US5817032A (en) | 1996-05-14 | 1998-10-06 | Biopath Automation Llc. | Means and method for harvesting and handling tissue samples for biopsy analysis |
GB9701930D0 (en) * | 1997-01-30 | 1997-03-19 | Life Sciences Int Europe | Tissue processing apparatus and method |
-
2001
- 2001-10-19 NO NO20015130A patent/NO315063B1/no not_active IP Right Cessation
-
2002
- 2002-10-10 JP JP2003536720A patent/JP4095028B2/ja not_active Expired - Fee Related
- 2002-10-10 WO PCT/NO2002/000366 patent/WO2003034033A1/en active Application Filing
- 2002-10-10 EP EP02801601A patent/EP1436587A1/en not_active Withdrawn
- 2002-10-10 US US10/492,885 patent/US7547542B2/en not_active Expired - Fee Related
- 2002-10-10 CA CA2462984A patent/CA2462984C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20050100981A1 (en) | 2005-05-12 |
NO315063B1 (no) | 2003-06-30 |
WO2003034033A1 (en) | 2003-04-24 |
CA2462984C (en) | 2013-01-29 |
US7547542B2 (en) | 2009-06-16 |
EP1436587A1 (en) | 2004-07-14 |
JP2005505776A (ja) | 2005-02-24 |
NO20015130D0 (no) | 2001-10-19 |
NO20015130L (no) | 2003-04-22 |
CA2462984A1 (en) | 2003-04-24 |
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