JP4042143B2 - Hollow fiber membrane module leak inspection method - Google Patents
Hollow fiber membrane module leak inspection method Download PDFInfo
- Publication number
- JP4042143B2 JP4042143B2 JP2000320634A JP2000320634A JP4042143B2 JP 4042143 B2 JP4042143 B2 JP 4042143B2 JP 2000320634 A JP2000320634 A JP 2000320634A JP 2000320634 A JP2000320634 A JP 2000320634A JP 4042143 B2 JP4042143 B2 JP 4042143B2
- Authority
- JP
- Japan
- Prior art keywords
- hollow fiber
- liquid
- space
- fiber membrane
- membrane module
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Description
【0001】
【発明の属する技術分野】
本発明は、中空糸膜モジュール、特に中空糸膜の微細孔部分にグリセリンを含む中空糸膜モジュールのリーク検査方法に関する。
【0002】
【従来の技術】
医療用に用いられる血液処理装置には、一般に、多数の中空糸からなる中空糸膜モジュールが採用されており、通常、中空糸の内側に血液を流し、外側に透析液を流すことにより使用されている。血液処理は、この中空糸の膜を通して物質交換を行うものであり、そのため、中空糸膜モジュールを構成する中空糸の中に損傷した物が混じっていると、血液が中空糸の外に漏れてしまう所謂リークが発生し、血液処理装置としての機能が損なわれてしまう。
【0003】
そのため、従来、中空糸膜の微細孔部分にグリセリンを含む中空糸膜モジュールの場合、中空糸の内側空間にエアーを加圧封入し、一定時間の圧力降下を測定することにより中空糸モジュールのリークの有無を検査している。また、中空糸の内側空間又は外側空間の一方の空間に加圧気体を充填し、他方の空間に液体又は気体を封入して、他方の空間の圧力を測定する方法が提案されている(特開平5−157654号公報参照)。
【0004】
しかしながら、上記方法を含む従来のリーク検査方法では、微細孔部分に含まれるグリセリンの含有量が少ない場合、微小のエアー漏れが生じることがあり、そのため、中空糸に欠損が無い場合でも不良と判定されることがあった。さらに、特開平5−157654号公報に開示された方法では、検査精度を向上させるために、加圧側および測定側の両側の配管の密閉性が要求される。
【0005】
【発明が解決しようとする課題】
本発明は如上の事情に鑑みてなされたもので、検査時間が短く確実なリーク検査方法を提供することを目的とする。
【0006】
【課題を解決するための手段】
本発明者等は、上記の課題を解決するために鋭意検討の結果、中空糸の内側空間又は外側空間を液体で満たし、該内側空間又は外側空間を加圧することにより、グリセリンの含有量のバラツキを補うことが出きることに想到し、本発明に到達した。すなわち、本発明は、中空糸の内側空間又は外側空間に液体を充填した後、該液体の充填された空間を加圧し、該加圧状態をしばらく維持した後、該液体の充填された空間の圧力降下を測定することを特徴とする中空糸膜モジュールのリーク検出方法に関する。ここで、液体の充填された空間の圧力降下は、この空間に気体の充填された気密な気体室を連通し、この気体室の圧力降下を測定する様にしてもよい。尚、中空糸の内側空間又は外側空間に充填する液体を洗浄液にすれば、リーク検査と同時に洗浄を行うことができる。
【0007】
【発明の実施の形態】
次に本発明の実施例について図面を用いて説明する。
図1は本発明の方法に採用されるリーク検出装置の一例を示す図であり、中空糸の内側空間に液体を充填する場合に採用される。
図中、1は中空糸の内側空間と連通するライン、2は中空糸の外側空間と連通するライン、3はモジュール、4は送液ポンプ、5は気体室、6は圧力計、7は加圧ライン、V1〜V6は開閉弁である。
先ず開閉弁V1、V2を開き、送液ポンプ4により、ライン1を通してモジュール3の(中空糸の)内側空間に洗浄液(例えばn−ノナン)を充填する。次に、開閉弁V1、V2を閉じ、開閉弁V3、V4を開くことにより、ライン7を通して実質的に液体に不溶な気体(例えば清浄な空気)を送り、モジュール3の内側空間および気体室を所定時間加圧した後、開閉弁V3、V4を閉じ、V5を開いてモジュール3の内側空間と気体室5を連通させる。
【0008】
この時、欠陥の無い中空糸膜の場合には、圧力計6により検出される液体側の圧力降下は、液体の表面張力の働きにより微小であり、一定時間における圧力の降下量は予め検知し得る。一方、欠損のある中空糸膜の場合には、欠損部より液体が流出し、圧力降下量が大きくなる。さらに、著しい欠損がある場合には、加圧中の圧上昇速度が小さくなり、測定圧力に到達しない。
【0009】
圧力測定後、開閉弁V1、V2を開き、送液ポンプ4によりライン1、2を通してモジュール3の内空間に洗浄液を送って、内空間の洗浄を行うことができる。
尚、ここでは中空糸の内側空間に液体を充填するようにした場合について説明したが、外側空間に液体を充填するようにした場合には、加圧ラインおよび気体室を中空糸の外側空間と連通するラインに接続し、同様の操作を行うようにすればよい。
【0010】
〔実施例〕 図1に示すリーク検出装置を用い、セルロースアセテート系中空糸膜モジュール((株)ニッショー製)について、本発明の方法によりリーク試験を行い、欠損を有することが分かっているモジュール(不良品)と、欠損の無いモジュール(良品)について、一定時間における圧力降下の状態を比較した。その結果を図2に示す。
但し、充填する液体としては、n−ノナンを用い、加圧圧力を150kPa、気体室容積を5ml、圧力測定時間を10秒とした。
【0011】
【発明の効果】
以上説明してきたことから明らかなように、本発明を採用すれば、検査時間の短縮と歩留まりの向上により、中空糸膜モジュールの製造コストの低減に資することが出来る。
【図面の簡単な説明】
【図1】 本発明の方法に採用されるリーク検出装置の一例を示す図であり、中空糸の内側空間に液体を充填する場合に採用される。
【図2】 本発明を適用した場合の圧力降下量の分布図である。
【符号の説明】
1 中空糸の内側空間と連通するライン
2 中空糸の外側空間と連通するライン
3 モジュール
4 送液ポンプ
5 気体室
6 圧力計
7 加圧ライン
V1〜V6 開閉弁[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a hollow fiber membrane module, and more particularly to a leak inspection method for a hollow fiber membrane module containing glycerin in a micropore portion of the hollow fiber membrane.
[0002]
[Prior art]
In general, a hollow fiber membrane module composed of a number of hollow fibers is employed in a blood treatment apparatus used for medical purposes, and is usually used by flowing blood inside the hollow fiber and flowing dialysate outside. ing. In blood treatment, mass exchange is performed through the hollow fiber membrane. Therefore, if damaged materials are mixed in the hollow fibers constituting the hollow fiber membrane module, blood leaks out of the hollow fibers. In other words, a so-called leak occurs, and the function as a blood processing apparatus is impaired.
[0003]
Therefore, conventionally, in the case of a hollow fiber membrane module that contains glycerin in the micropore portion of the hollow fiber membrane, air is pressurized and sealed in the inner space of the hollow fiber, and the leakage of the hollow fiber module is measured by measuring the pressure drop for a certain period of time. The presence or absence is inspected. In addition, a method has been proposed in which one of the inner space and the outer space of the hollow fiber is filled with a pressurized gas and liquid or gas is sealed in the other space, and the pressure in the other space is measured (special feature). (See Kaihei 5-157654).
[0004]
However, in the conventional leak inspection method including the above method, if the content of glycerin contained in the micropore portion is small, minute air leakage may occur, and therefore, even if there is no defect in the hollow fiber, it is determined to be defective. There was something to be done. Furthermore, in the method disclosed in Japanese Patent Laid-Open No. 5-157654, in order to improve the inspection accuracy, the sealing of the piping on both sides of the pressure side and the measurement side is required.
[0005]
[Problems to be solved by the invention]
The present invention has been made in view of the above circumstances, and an object thereof is to provide a reliable leak inspection method with a short inspection time.
[0006]
[Means for Solving the Problems]
As a result of intensive studies to solve the above-mentioned problems, the inventors have filled the inner space or outer space of the hollow fiber with a liquid and pressurized the inner space or outer space, thereby varying the content of glycerin. As a result, the present invention has been reached. That is, in the present invention, after filling the inner space or the outer space of the hollow fiber with a liquid, the space filled with the liquid is pressurized, and after maintaining the pressurized state for a while, the space filled with the liquid The present invention relates to a leak detection method for a hollow fiber membrane module, characterized by measuring a pressure drop. Here, the pressure drop in the space filled with the liquid may be such that an airtight gas chamber filled with the gas is communicated with the space and the pressure drop in the gas chamber is measured. If the liquid filling the inner space or the outer space of the hollow fiber is used as a cleaning liquid, cleaning can be performed simultaneously with the leak inspection.
[0007]
DETAILED DESCRIPTION OF THE INVENTION
Next, embodiments of the present invention will be described with reference to the drawings.
FIG. 1 is a diagram showing an example of a leak detection apparatus employed in the method of the present invention, which is employed when a liquid is filled in the inner space of a hollow fiber.
In the figure, 1 is a line communicating with the inner space of the hollow fiber, 2 is a line communicating with the outer space of the hollow fiber, 3 is a module, 4 is a liquid feed pump, 5 is a gas chamber, 6 is a pressure gauge, and 7 is a pressure gauge. The pressure lines V1 to V6 are on-off valves.
First, the on-off valves V1 and V2 are opened, and a cleaning liquid (for example, n-nonane) is filled into the inner space (of the hollow fiber) of the
[0008]
At this time, in the case of a hollow fiber membrane having no defect, the pressure drop on the liquid side detected by the
[0009]
After the pressure measurement, the on-off valves V1 and V2 are opened, and the cleaning liquid can be sent to the inner space of the
Here, the case where the liquid is filled in the inner space of the hollow fiber has been described, but when the liquid is filled in the outer space, the pressurization line and the gas chamber are connected to the outer space of the hollow fiber. A similar operation may be performed by connecting to a communicating line.
[0010]
[Example] Using the leak detection apparatus shown in FIG. 1, a cellulose acetate-based hollow fiber membrane module (manufactured by Nissho Co., Ltd.) was subjected to a leak test according to the method of the present invention, and a module known to have a defect ( The state of pressure drop over a certain period of time was compared between a defective product and a module without defects (good product). The result is shown in FIG.
However, n-nonane was used as the liquid to be filled, the pressurizing pressure was 150 kPa, the gas chamber volume was 5 ml, and the pressure measurement time was 10 seconds.
[0011]
【The invention's effect】
As is apparent from the above description, the use of the present invention can contribute to the reduction of the manufacturing cost of the hollow fiber membrane module by shortening the inspection time and improving the yield.
[Brief description of the drawings]
FIG. 1 is a diagram showing an example of a leak detection apparatus employed in the method of the present invention, which is employed when a liquid is filled in the inner space of a hollow fiber.
FIG. 2 is a distribution diagram of an amount of pressure drop when the present invention is applied.
[Explanation of symbols]
DESCRIPTION OF
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000320634A JP4042143B2 (en) | 2000-10-20 | 2000-10-20 | Hollow fiber membrane module leak inspection method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000320634A JP4042143B2 (en) | 2000-10-20 | 2000-10-20 | Hollow fiber membrane module leak inspection method |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002126471A JP2002126471A (en) | 2002-05-08 |
JP4042143B2 true JP4042143B2 (en) | 2008-02-06 |
Family
ID=18798885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000320634A Expired - Fee Related JP4042143B2 (en) | 2000-10-20 | 2000-10-20 | Hollow fiber membrane module leak inspection method |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP4042143B2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2686319C (en) | 2007-05-25 | 2012-11-13 | Gambro Lundia Ab | A device for connecting to a liquid source |
-
2000
- 2000-10-20 JP JP2000320634A patent/JP4042143B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2002126471A (en) | 2002-05-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP3111101B2 (en) | Leak inspection method for membrane separation equipment | |
KR100303972B1 (en) | Device and Method for Detecting Leakage of Filter Film | |
JPH0318373A (en) | Method and device for detecting leak of hollow fiber membrane type liquid processor | |
JPH0357458A (en) | Inspecting method for hemodialysis membrane | |
CN108267274A (en) | The leak detection method of gas container | |
JP4042143B2 (en) | Hollow fiber membrane module leak inspection method | |
JPH0251135B2 (en) | ||
CN206114658U (en) | Rubber tube detection device | |
JP2004085254A (en) | Leakage inspection method and equipment | |
JP4316446B2 (en) | Leakage inspection method for inlet seal of bag container | |
JP2001269551A (en) | Method for detecting rupture of permeable membrane module for water cleaning/treatment device | |
JP3897860B2 (en) | Sealed leak test method | |
EP0661529A3 (en) | Procedure and device for leak testing of a volume and for determining the leaking amount. | |
JP2003190747A (en) | Leak detection method for hollow-fiber membrane module | |
US9915580B2 (en) | Pulp chamber leak test | |
JP4288006B2 (en) | Method of performing leak test by integration method on specimen with relatively thin wall | |
JP2008180664A (en) | Method and device for inspecting liquidtightness of dispenser for drink | |
JP3758337B2 (en) | Airtight inspection device for cylindrical inspection object | |
FR2638841A1 (en) | METHOD AND DEVICE FOR TESTING THE PERMEABILITY OF SEALED COMBINATIONS AS NOTABLY USED IN THE AERONAUTICAL FIELD | |
JP4338403B2 (en) | Inspection apparatus and inspection method for gas permeable hollow fiber membrane module | |
Jornitz et al. | Experimental evaluations of diffusive airflow integrity testing | |
JPH08219961A (en) | Withstanding pressure test equipment for brake hose | |
JP2001099745A (en) | Sealing performance testing method for sealed container, sealing performance testing apparatus and manufacturing apparatus therefor, and sealed container | |
JPH07286928A (en) | Helium leak detector | |
JPH0531094B2 (en) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20050203 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20061207 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20061218 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070216 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20071022 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20071104 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 4042143 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20101122 Year of fee payment: 3 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131122 Year of fee payment: 6 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |