JP3515821B2 - Disinfecting composition - Google Patents

Disinfecting composition

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Publication number
JP3515821B2
JP3515821B2 JP28297694A JP28297694A JP3515821B2 JP 3515821 B2 JP3515821 B2 JP 3515821B2 JP 28297694 A JP28297694 A JP 28297694A JP 28297694 A JP28297694 A JP 28297694A JP 3515821 B2 JP3515821 B2 JP 3515821B2
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JP
Japan
Prior art keywords
chlorhexidine
ethyl alcohol
acid
disinfecting composition
stability
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP28297694A
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Japanese (ja)
Other versions
JPH08119811A (en
Inventor
保生 五十嵐
喬 鈴木
朋子 木村
晃 本山
吏奈 福原
敦子 鳥居
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shiseido Co Ltd
Original Assignee
Shiseido Co Ltd
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Filing date
Publication date
Application filed by Shiseido Co Ltd filed Critical Shiseido Co Ltd
Priority to JP28297694A priority Critical patent/JP3515821B2/en
Priority to US08/544,633 priority patent/US5800827A/en
Priority to EP95307484A priority patent/EP0707794B1/en
Priority to AU34398/95A priority patent/AU694264B2/en
Priority to DE69520639T priority patent/DE69520639T2/en
Priority to KR1019950036325A priority patent/KR100414599B1/en
Publication of JPH08119811A publication Critical patent/JPH08119811A/en
Priority to KR1020030076748A priority patent/KR100437566B1/en
Application granted granted Critical
Publication of JP3515821B2 publication Critical patent/JP3515821B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Description

【発明の詳細な説明】Detailed Description of the Invention

【０００１】[0001]

【産業上の利用分野】本発明は消毒用組成物、特にエチ
ルアルコールベース中でのクロルヘキシジンの安定化に
関する。FIELD OF THE INVENTION The present invention relates to disinfecting compositions, especially to the stabilization of chlorhexidine in ethyl alcohol base.

【０００２】[0002]

【従来の技術】クロルヘキシジンは、正式名称が１，１
−ヘキサメチレンビス［５−（４−クロロフェニル）ビ
グアニド］である化合物であり、持続的且つ広分野の殺
菌作用があるため、疾患の殺菌性予防薬や、防腐剤、防
臭剤、或いは消炎剤として、歯槽膿漏薬や消毒薬などに
配合されている。Chlorhexidine has a formal name of 1,1.
-Hexamethylenebis [5- (4-chlorophenyl) biguanide], which is a compound having a long-lasting and wide-ranging bactericidal action, is used as a bactericidal and preventive agent for diseases, antiseptics, deodorants, or anti-inflammatory agents , It is contained in alveolar pyorrhea and antiseptic.

【０００３】一方、昨今では病院での院内感染が新聞紙
上を賑わしており、クロルヘキシジンのように広範囲の
殺菌に用い得る化合物は、今後益々需要が期待される。
前記病院内での院内感染においては、一の患者から、医
師や看護婦を介して別の患者に感染するケースもあるこ
とが報告されており、一人の患者の治療や介護のあと、
別の患者の治療に当る前に、完全に且つ迅速に手指の消
毒を行なわなければならない。このため、最近ではエチ
ルアルコールを主成分とした速乾性の消毒薬が各種検討
されている。On the other hand, nosocomial infections in hospitals have been prevailing on newspapers in recent years, and compounds such as chlorhexidine that can be used for a wide range of sterilization are expected to be more and more demanded in the future.
In nosocomial infection in the hospital, it has been reported that one patient may infect another patient via a doctor or a nurse, and after treatment or care of one patient,
Complete and rapid hand disinfection must be performed before treating another patient. For this reason, various kinds of quick-drying disinfectants containing ethyl alcohol as a main component have recently been studied.

【０００４】[0004]

【発明が解決しようとする課題】しかしながら、エチル
アルコールのみでの殺菌性では不十分であり、一方グル
コン酸クロルヘキシジンの場合はもともと水溶性である
ため、水溶液系においては安定であるものの、エチルア
ルコール基剤中ではクロルヘキシジンの安定性が悪くな
ることが知られている。However, the bactericidal property with ethyl alcohol alone is not sufficient, while chlorhexidine gluconate is originally water-soluble, so it is stable in an aqueous system, but the ethyl alcohol group It is known that the stability of chlorhexidine deteriorates in the agent.

【０００５】ところが、速乾性及び殺菌力を維持するた
めにも、エタノールは消毒用エタノールと同程度配合さ
れていることが好ましく、速乾性を満足させつつ、クロ
ルヘキシジンを安定に配合した消毒剤の開発が待たれて
いるが、未だ充分満足するものは見出されていない。本
発明は前記従来技術の課題に鑑みなされたものであり、
その目的は高濃度エチルアルコール溶液中で安定にクロ
ルヘキシジンを配合した消毒用組成物を提供することに
ある。However, in order to maintain the quick-drying property and the sterilizing power, it is preferable that ethanol is blended to the same extent as the disinfecting ethanol, and the development of a disinfectant containing chlorhexidine stably while satisfying the fast-drying property. Have been waiting, but none have been found to be fully satisfied. The present invention has been made in view of the above problems of the prior art,
The purpose is to provide a disinfecting composition in which chlorhexidine is stably mixed in a high-concentration ethyl alcohol solution.

【０００６】[0006]

【課題を解決するための手段】前記目的を達成するため
に本発明者らが鋭意検討を行なった結果、有機酸を添加
することにより、高濃度エチルアルコール溶液中でクロ
ルヘキシジンが安定に配合されることを見出し、本発明
を完成するに至った。すなわち、本発明にかかる消毒用
組成物は、エチルアルコール濃度５０重量％以上と、ク
ロルヘキシジンと、有機酸と、を含み、系のｐＨは３〜
４．５であることを特徴とする。また、系のｐＨは３．
５〜４．５であることが好適である。また、添加される
有機酸は炭素数が２〜１６の有機酸からなる群から選択
されることが好適である。Means for Solving the Problems As a result of intensive studies by the present inventors in order to achieve the above-mentioned object, chlorhexidine is stably blended in a high-concentration ethyl alcohol solution by adding an organic acid. This has led to the completion of the present invention. That is, disinfectant compositions according to the present invention, viewed contains ethyl alcohol concentration of 50 wt% or more, and chlorhexidine, an organic acid, a, pH of the system 3
4.5 and wherein the Dearuko. The pH of the system is 3.
It is preferably 5 to 4.5 . Further, the organic acid to be added is preferably selected from the group consisting of organic acids having 2 to 16 carbon atoms.

【０００７】前記有機酸としては、５０％以上のエチル
アルコール濃度の溶液中に溶解し、且つ好ましくは系の
ｐＨを３〜４．５に調整し得ることが好適である。この
ような有機酸としては、酢酸、乳酸、マレイン酸、リン
ゴ酸、クエン酸、サリチル酸、ミリスチン酸、パルミチ
ン酸等が挙げられ、このうち特に乳酸、クエン酸が好適
である。It is preferable that the organic acid is dissolved in a solution having an ethyl alcohol concentration of 50% or more and preferably the pH of the system can be adjusted to 3 to 4.5 . Examples of such an organic acid include acetic acid, lactic acid, maleic acid, malic acid, citric acid, salicylic acid, myristic acid, palmitic acid and the like, of which lactic acid and citric acid are particularly preferable.

【０００８】また、本発明の消毒用組成物には他の配合
物を配合することもできる。たとえは、グリチルリチン
酸又はその誘導体、ビタミンＥ、ビタミンＥアセテー
ト、ビタミンＢ6などの薬剤、キサンタンガム、デキス
トリン、ヒドロキシエチルセルロース、ヒドロキシメチ
ルセルロース、メチルセルロース、カラギーナン、カル
ボキシメチルセルロースなどの水溶性高分子などが配合
できる。また、ノニオン界面活性剤や皮膚保護力の増強
として尿素などを配合し、洗浄効果をも付与することが
可能である。Further, the disinfecting composition of the present invention may contain other compounds. For example, glycyrrhizic acid or a derivative thereof, a drug such as vitamin E, vitamin E acetate, vitamin B 6 or the like, a water-soluble polymer such as xanthan gum, dextrin, hydroxyethyl cellulose, hydroxymethyl cellulose, methyl cellulose, carrageenan or carboxymethyl cellulose can be blended. In addition, it is possible to add a nonionic surfactant or urea or the like as an enhancement of the skin protection power to give a cleaning effect.

【０００９】[0009]

【実施例】以下、本発明の好適な実施例について説明す
る。なお、本発明はこれらの実施例に限定されるもので
はない。The preferred embodiments of the present invention will be described below. The present invention is not limited to these examples.

【００１０】エチルアルコール濃度とクロルヘキシジン
の安定性 まず、本発明者らはエチルアルコール濃度とクロルヘキ
シジンの安定性との関係について、検討を行なった。グ
ルコン酸クロルヘキシジンが０．２％W/V濃度となるよ
うに、下記エチルアルコール濃度の水溶液を調製し、５
０℃及び０℃に１ヵ月間保存し、各薬剤のクロルヘキシ
ジンの定量を行なった。なお、残存率は０℃での残存量
を１００％として、５０℃での残存割合を算出したもの
である。 Ethyl alcohol concentration and chlorhexidine
Stability First, the present inventors about the relationship between the stability of the ethyl alcohol concentration and chlorhexidine was performed investigated. Prepare an aqueous solution of the following ethyl alcohol concentration so that chlorhexidine gluconate has a concentration of 0.2% W / V.
It was stored at 0 ° C. and 0 ° C. for 1 month, and chlorhexidine of each drug was quantified. The residual rate is calculated by setting the residual amount at 0 ° C as 100% and calculating the residual rate at 50 ° C.

【表１】 ────────────────────────────────── ０ １０ ２０ ３０ ４０ ５０ ６０ ７０ ８０ ────────────────────────────────── 残存率 １００ ９５ ８１ ７５ ６９ ６５ ５８ ５３ ４８ ────────────────────────────────── 一方、エチルアルコールによる速乾性、殺菌力向上を期
待する場合には、エチルアルコール濃度５０％以上は必
要であり、好ましくは７０％以上である。そこで、本発
明者らはこのクロルヘキシジンの高濃度エチルアルコー
ル中での安定性の向上について検討を行なった。[Table 1] ────────────────────────────────── 0 10 20 30 40 40 50 60 70 70 80 ─── ─────────────────────────────── Residual rate 100 995 81 75 69 69 65 58 58 53 48 ───────── ────────────────────────── On the other hand, when expecting quick-drying and sterilizing power improvement with ethyl alcohol, ethyl alcohol concentration of 50% or more Is necessary and is preferably 70% or more. Therefore, the present inventors have examined the improvement of the stability of chlorhexidine in high-concentration ethyl alcohol.

【００１１】各種添加剤と安定性 本発明者らはクロルヘキシジンのエチルアルコール中で
の安定化を図る目的で、人体に影響を与えることの少な
い各種物質を添加した。なお、エチルアルコール濃度は
８０V/V％とし、各添加物は０．１W/V％となるように添
加した。また、安定性の評価については、前記同様に行
なった。結果を次の表２に示す。 Various Additives and Stability For the purpose of stabilizing chlorhexidine in ethyl alcohol, the present inventors added various substances that have little effect on the human body. The ethyl alcohol concentration was 80 V / V%, and each additive was added at 0.1 W / V%. The stability was evaluated in the same manner as above. The results are shown in Table 2 below.

【表２】 ──────────────────── 添加剤 残存率 ──────────────────── アラントイン ９２％ ──────────────────── グリシン ９１％ ──────────────────── クエン酸 ９９％ ──────────────────── 乳酸 ９９％ ──────────────────── ブチルヒドロキシトルエン ９１％ ──────────────────── トコフェロール ９４％ ──────────────────── 上記表２より、各種添加物の中で、特にクエン酸、乳酸
などの炭素数２〜１６の有機酸が極めて高い安定性付与
作用を有することが明かとなった。[Table 2] ──────────────────── Additive residual rate ───────────────────── Allantoin 92 % ──────────────────── Glycine 91% ───────────────────── Citric acid 99% ── ────────────────── Lactic acid 99% ──────────────────── Butylhydroxytoluene 91% ──── ──────────────── Tocopherol 94% ──────────────────── From Table 2 above, among the various additives In particular, it has been revealed that organic acids having 2 to 16 carbon atoms such as citric acid and lactic acid have a very high stability-imparting action.

【００１２】有機酸の添加による系のｐＨと安定性 次に、エチルアルコール濃度８０重量％の系で、有機酸
の添加量により系のｐＨを変化させてクロルヘキシジン
の安定性を評価した。なお、安定性の評価については、
前記同様に行なった。また、高濃度アルコール系での直
接的なｐＨ測定は困難であるので、被検液５ｇをとり、
一度煮沸し冷却した精製水を加えて全量を５０ｇとし、
次に室温下、攪拌しながらｐＨを測定した。結果を図１
に示す。同図より明らかなように、ｐＨが３〜５の領域
で効果が認められ、特にｐＨ４の附近にクロルヘキシジ
ン安定化の極大領域が存在した。 PH and Stability of System by Addition of Organic Acid Next, the stability of chlorhexidine was evaluated in a system having an ethyl alcohol concentration of 80% by weight by changing the pH of the system depending on the amount of the organic acid added. For stability evaluation,
The same procedure as above was performed. Further, since it is difficult to directly measure pH with a high-concentration alcohol system, take 5 g of the test liquid,
Add boiled and cooled purified water to bring the total amount to 50 g,
Next, the pH was measured at room temperature with stirring. The result is shown in Figure 1.
Shown in. As is clear from the figure, the effect was recognized in the pH range of 3 to 5, and particularly, the maximum chlorhexidine stabilization region was present near pH 4.

【００１３】この結果、少量の添加量でエチルアルコー
ル濃度５０％以上の溶液をｐＨ３〜５に調整できる化合
物としては、特に前記クエン酸、乳酸などが好適である
ことが理解される。As a result, it is understood that the above-mentioned citric acid, lactic acid and the like are particularly suitable as the compound capable of adjusting the pH of the solution having an ethyl alcohol concentration of 50% or more to pH 3 to 5 with a small amount of addition.

【００１４】次に、クロルヘキシジンを安定に配合した
消毒用組成物のより具体的な配合例を示す。配合例１ ヒビテングルコネート液（２０％クロルヘキシジン） １．０ｇ カチオン性界面活性剤 ０．０２ トリイソオクタン酸グリセリン ０．４ クエン酸 ０．１ 精製水 １８．０ エタノール １００mlに調整Next, a more specific formulation example of the disinfecting composition in which chlorhexidine is stably incorporated will be shown. Formulation 1 Hibitene gluconate solution (20% chlorhexidine) 1.0 g Cationic surfactant 0.02 Glycerin triisooctanoate 0.4 Citric acid 0.1 Purified water 18.0 Ethanol 100 ml adjusted

【００１５】配合例２ ヒビテングルコネート液（２０％クロルヘキシジン） １．０ｇ カチオン性界面活性剤 ０．０２ トリイソオクタン酸グリセリン ０．４ 乳酸 ０．１ 精製水 １８．０ エタノール １００mlに調整 いずれの配合例にかかる消毒用組成物も、優れた安定性
を有していた。 Formulation 2 Hibitene gluconate liquid (20% chlorhexidine) 1.0 g Cationic surfactant 0.02 Glycerin triisooctanoate 0.4 Lactic acid 0.1 Purified water 18.0 Ethanol 100 ml The disinfecting composition of the present invention also had excellent stability.

【００１６】[0016]

【発明の効果】以上説明したように本発明にかかる消毒
用組成物によれば、有機酸を添加し、系のｐＨを３〜
４．５とすることにより、５０％以上のエチルアルコー
ル濃度下にあってもクロルヘキシジンを極めて安定に配
合することができる。As described above, according to the disinfecting composition of the present invention, the pH of the system is adjusted to 3 to 3 by adding an organic acid.
By setting it to 4.5, chlorhexidine can be blended extremely stably even under an ethyl alcohol concentration of 50% or more.

【図面の簡単な説明】[Brief description of drawings]

【図１】クエン酸、乳酸系におけるクロルヘキシジンの
残存率と系のｐＨとの関係を示す説明図である。FIG. 1 is an explanatory diagram showing the relationship between the residual ratio of chlorhexidine in citric acid and lactic acid systems and the pH of the system.

フロントページの続き (72)発明者 木村 朋子 神奈川県横浜市金沢区福浦２−12−１ 株式会社 資生堂 第二リサーチセンタ ー内 (72)発明者 本山 晃 神奈川県横浜市金沢区福浦２−12−１ 株式会社 資生堂 第二リサーチセンタ ー内 (72)発明者 福原 吏奈 神奈川県横浜市金沢区福浦２−12−１ 株式会社 資生堂 第二リサーチセンタ ー内 (72)発明者 鳥居 敦子 神奈川県横浜市金沢区福浦２−12−１ 株式会社 資生堂 第二リサーチセンタ ー内 (56)参考文献 特開 平２−140167（ＪＰ，Ａ) 特表 昭61−500357（ＪＰ，Ａ) 米国特許5334388（ＵＳ，Ａ) 英国特許出願公開2187097（ＧＢ，Ａ) (58)調査した分野(Int.Cl.7，ＤＢ名) A01N 47/44 A01N 31/02 A01N 37/00 A01N 25/22 A61L 2/16 A61K 7/16 ＣＡＰＬＵＳ（ＳＴＮ) ＲＥＧＩＳＴＲＹ（ＳＴＮ) ＪＩＣＳＴファイル（ＪＯＩＳ)Front Page Continuation (72) Inventor Tomoko Kimura 2-12-1, Fukuura, Kanazawa-ku, Yokohama-shi, Kanagawa Shiseido Co., Ltd. 2nd Research Center (72) Akira Motoyama 2-12- Fukuura, Kanazawa-ku, Yokohama, Kanagawa Prefecture 1 Shiseido Co., Ltd. 2nd Research Center (72) Inventor Reina Fukuhara 2-12-1, Fukuura, Kanazawa-ku, Yokohama-shi, Kanagawa Prefecture Shiseido 2nd Research Center (72) Inventor Atsuko Torii Kanazawa, Yokohama, Kanagawa 2-12-1, Fukuura, Ward Shiseido Co., Ltd. 2nd Research Center (56) Reference JP-A-2-140167 (JP, A) Special Table Sho 61-500357 (JP, A) US Patent 5334388 (US, A) ) British Patent Application Publication 2187097 (GB, A) (58) Fields searched (Int.Cl. 7 , DB name) A01N 47/44 A01N 31/02 A01N 37/00 A01N 25/22 A61L 2/16 A61K 7 / 16 CAPLUS (STN) REGISTRY (STN) JISST file (JOIS)

Claims (4)

(57)【特許請求の範囲】(57) [Claims] 【請求項１】 エチルアルコール濃度５０重量％以上
と、クロルヘキシジンと、有機酸と、を含み、系のｐＨ
は３〜４．５である消毒用組成物。And 1. A ethyl alcohol concentration of 50 wt% or more, viewed contains chlorhexidine, an organic acid, a, pH of the system
Disinfection for the composition, which is a 3 to 4.5 in. 【請求項２】 請求項１記載の組成物において、系のｐ
Ｈは３．５〜４．５であることを特徴とする消毒用組成
物。2. The composition of claim 1, wherein the p of the system is
The disinfecting composition, wherein H is 3.5 to 4.5 . 【請求項３】 請求項１又は２記載の組成物において、
添加される有機酸は炭素数が２〜１６の有機酸からなる
群から選択されることを特徴とする消毒用組成物。3. The composition according to claim 1 or 2, wherein
The disinfecting composition, wherein the added organic acid is selected from the group consisting of organic acids having 2 to 16 carbon atoms. 【請求項４】 請求項１ないし３のいずれかに記載組成
物において、有機酸は乳酸及び／又はクエン酸であるこ
とを特徴とする消毒用組成物。4. The disinfecting composition according to any one of claims 1 to 3, wherein the organic acid is lactic acid and / or citric acid.
JP28297694A 1994-10-21 1994-10-21 Disinfecting composition Expired - Fee Related JP3515821B2 (en)

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JP28297694A JP3515821B2 (en) 1994-10-21 1994-10-21 Disinfecting composition
US08/544,633 US5800827A (en) 1994-10-21 1995-10-18 Disinfectant composition
AU34398/95A AU694264B2 (en) 1994-10-21 1995-10-20 Disinfectant composition
DE69520639T DE69520639T2 (en) 1994-10-21 1995-10-20 Disinfectant composition
EP95307484A EP0707794B1 (en) 1994-10-21 1995-10-20 Disinfectant composition
KR1019950036325A KR100414599B1 (en) 1994-10-21 1995-10-20 Disinfectant composition comprising alcohol, chlorhexidine and organic acid and finger disinfection method using same
KR1020030076748A KR100437566B1 (en) 1994-10-21 2003-10-31 Disinfectant composition comprising alcohol, chlorhexidine and an organic acid

Applications Claiming Priority (1)

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JP28297694A JP3515821B2 (en) 1994-10-21 1994-10-21 Disinfecting composition

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JPH08119811A JPH08119811A (en) 1996-05-14
JP3515821B2 true JP3515821B2 (en) 2004-04-05

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Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19713850A1 (en) 1997-04-04 1998-10-08 Henkel Ecolab Gmbh & Co Ohg Disinfection procedure (II)
JP3636611B2 (en) * 1999-03-19 2005-04-06 日華化学株式会社 Disinfectant composition
US6899897B2 (en) 2001-06-18 2005-05-31 Jaleva, Inc. Gum resin as a carrier for topical application of pharmacologically active agents
EP1530485A1 (en) 2002-08-20 2005-05-18 Alda Pharmaceuticals Corp. A wide spectrum disinfectant
US9028852B2 (en) * 2004-09-07 2015-05-12 3M Innovative Properties Company Cationic antiseptic compositions and methods of use
US20060074029A1 (en) * 2004-10-04 2006-04-06 Scott Leece Topical antimicrobial composition having improved moisturization properties
RU2380099C2 (en) * 2004-12-09 2010-01-27 Дзе Дайл Корпорэйшн Compositions with high antiviral and antibacterial efficiency
US20090012174A1 (en) * 2004-12-09 2009-01-08 The Dial Corporation Compositions Having a High Antiviral and Antibacterial Efficacy
US20080199535A1 (en) * 2004-12-09 2008-08-21 The Dial Corporation Compositions Having a High Antiviral and Antibacterial Efficacy
US20080267904A1 (en) * 2004-12-09 2008-10-30 The Dial Corporation Compositions Having A High Antiviral And Antibacterial Efficacy
RU2366460C2 (en) * 2004-12-09 2009-09-10 Дзе Дайл Корпорэйшн Compositions with high antiviral and antibacterial action
CA2588802A1 (en) * 2004-12-09 2006-06-15 The Dial Corporation Compositions having a high antiviral and antibacterial efficacy
US20080317690A1 (en) * 2005-11-07 2008-12-25 Alex Battaglia Film-Forming Resins as a Carrier for Topical Application of Pharmacologically Active Agents
US20070175972A1 (en) * 2005-11-10 2007-08-02 Ringer Eric M Manually actuated contactless card
US8119115B2 (en) 2006-02-09 2012-02-21 Gojo Industries, Inc. Antiviral method
US9629361B2 (en) 2006-02-09 2017-04-25 Gojo Industries, Inc. Composition and method for pre-surgical skin disinfection
US8450378B2 (en) 2006-02-09 2013-05-28 Gojo Industries, Inc. Antiviral method
US20070275929A1 (en) * 2006-05-24 2007-11-29 The Dial Corporation Composition and method for controlling the transmission of noroviruses
EP2040544A2 (en) * 2006-05-26 2009-04-01 The Dial Corporation Method of inhibiting the transmission of viruses
MX2008015188A (en) * 2006-05-30 2009-03-06 Dial Corp Compositions having a high antiviral effeicacy.
WO2007142967A2 (en) * 2006-05-31 2007-12-13 The Dial Corporation Alcohol-containing antimicrobial compositions having improved efficacy
MX2008015336A (en) 2006-06-02 2008-12-16 Dial Corp Method of inhibiting the transmission of influenza virus.
EP2046120A2 (en) * 2006-06-05 2009-04-15 The Dial Corporation Methods and articles having a high antiviral and antibacterial efficacy
DE102009009517A1 (en) 2009-02-18 2010-08-19 Sprick Gmbh Bielefelder Papier- Und Wellpappenwerke & Co. Drive mechanism for a device for laying a fiber material web in a Leporellofaltung
EP2503883B1 (en) * 2009-11-24 2016-03-02 Fresenius Medical Care Deutschland GmbH Disinfectant composition
EP3736319A1 (en) 2014-02-07 2020-11-11 GOJO Industries, Inc. Compositions and methods with efficacy against spores and other organisms
US9578879B1 (en) 2014-02-07 2017-02-28 Gojo Industries, Inc. Compositions and methods having improved efficacy against spores and other organisms
CN104622852B (en) * 2015-02-10 2017-08-25 山东天达有限公司 A kind of polysaccharide-modified ethanol water and its preparation method and application
US10813357B1 (en) * 2015-05-26 2020-10-27 Gojo Industries, Inc. Compositions and methods with efficacy against spores and other organisms
DE102015122276A1 (en) 2015-12-18 2017-06-22 Schülke & Mayr GmbH Alcoholic compositions containing octenidine dihydrochloride
DE102015122263A1 (en) 2015-12-18 2017-06-22 Schülke & Mayr GmbH Alcoholic disinfectant for the control of viruses
EP3413716A1 (en) 2016-02-12 2018-12-19 Salicylates & Chemicals Pvt ltd Synthesis and application of an antimicrobial active
US10813892B2 (en) 2016-05-24 2020-10-27 Carefusion 2200, Inc. Antiseptic solutions and applicators
CN112654248A (en) * 2018-09-14 2021-04-13 3M创新有限公司 Antimicrobial compositions comprising chlorhexidine
KR102267156B1 (en) 2020-12-23 2021-06-21 주식회사 비바케어 (Composition for sterilization or disinfection and manufacturing method thereof
CN116530515A (en) * 2022-01-26 2023-08-04 上海交通大学 Disinfection product based on citric acid and natural naphthoquinone compounds

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0696522B2 (en) * 1983-10-24 1994-11-30 ロクリ− サ−ヴイシズ プロプライエタリ− リミテツド Foaming biocidal composition
DE3542516A1 (en) * 1985-12-02 1987-06-04 Henkel Kgaa DISINFECTANT
GB8604986D0 (en) * 1986-02-28 1986-04-09 Unilever Plc Disinfectant compositions
DE3702983A1 (en) * 1986-06-09 1987-12-10 Henkel Kgaa DISINFECTANT AND THEIR USE FOR SKIN AND MUCUS SKIN DISINFECTION
DE3743374A1 (en) * 1987-12-21 1989-06-29 Henkel Kgaa USE OF BISGUANIDE-CONTAINING COMPOSITIONS AGAINST EGGS OF THE MEGEWORM
DE3809980C2 (en) * 1988-03-24 1998-02-19 Stankiewicz Gmbh Structure for sound insulation, process for its production and its use
JPH02140167A (en) * 1988-11-22 1990-05-29 Saraya Kk Composition for disinfecting hand and finger
US5004757A (en) * 1988-12-20 1991-04-02 Wave Energy Systems, Inc. Virucidal low toxicity compositions
JPH03215411A (en) * 1989-09-14 1991-09-20 Kanebo Ltd Mouth washing solution
US5167950A (en) * 1991-03-28 1992-12-01 S. C. Johnson & Son High alcohol content aerosol antimicrobial mousse
KR940010078A (en) * 1992-10-06 1994-05-24 윤종용 How to switch to the main screen during multi-screen recording
US5334388A (en) * 1993-09-15 1994-08-02 Becton, Dickinson And Company Antimicrobial drying substrate
WO1995012395A1 (en) * 1993-11-05 1995-05-11 E.R. Squibb And Sons, Inc. Topical antimicrobial cleanser containing chlorhexidine gluconate and alcohol

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AU3439895A (en) 1996-05-02
KR100437566B1 (en) 2004-06-30
JPH08119811A (en) 1996-05-14
DE69520639D1 (en) 2001-05-17
EP0707794B1 (en) 2001-04-11
US5800827A (en) 1998-09-01
AU694264B2 (en) 1998-07-16
KR960013197A (en) 1996-05-22
DE69520639T2 (en) 2001-08-02
EP0707794A1 (en) 1996-04-24

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