JP3515140B2 - Ascites inhibitor for broiler and method for preventing ascites - Google Patents

Ascites inhibitor for broiler and method for preventing ascites

Info

Publication number
JP3515140B2
JP3515140B2 JP07724793A JP7724793A JP3515140B2 JP 3515140 B2 JP3515140 B2 JP 3515140B2 JP 07724793 A JP07724793 A JP 07724793A JP 7724793 A JP7724793 A JP 7724793A JP 3515140 B2 JP3515140 B2 JP 3515140B2
Authority
JP
Japan
Prior art keywords
ascites
broilers
broiler
preventing
feed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP07724793A
Other languages
Japanese (ja)
Other versions
JPH06287136A (en
Inventor
倫也 青山
賢郎 武居
寿昭 中島
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Idemitsu Petrochemical Co Ltd
Original Assignee
Idemitsu Petrochemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idemitsu Petrochemical Co Ltd filed Critical Idemitsu Petrochemical Co Ltd
Priority to JP07724793A priority Critical patent/JP3515140B2/en
Priority to PCT/JP1994/000519 priority patent/WO1994022433A1/en
Priority to CN94192212A priority patent/CN1101186C/en
Priority to AU62919/94A priority patent/AU6291994A/en
Publication of JPH06287136A publication Critical patent/JPH06287136A/en
Application granted granted Critical
Publication of JP3515140B2 publication Critical patent/JP3515140B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Feed For Specific Animals (AREA)
  • Fodder In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

【発明の詳細な説明】Detailed Description of the Invention

【０００１】[0001]

【産業上の利用分野】本発明は、ブロイラーの腹水症防
止剤、育成率向上剤及びこれらを用いて腹水症を防止
し、育成率を向上させる方法に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an agent for preventing ascites from broilers, a growth rate improving agent, and a method for preventing ascites and improving the growth rate using these agents.

【０００２】[0002]

【従来の技術】ブロイラー産業では、生産性を向上させ
るべく、ブロイラーが早く大きく増体重させるために、
用いる系統の育種、飼育方法を研究開発してきた。しか
し、これらの研究開発の結果、ブロイラーの増体速度は
大幅に向上したものの、この増体速度に心臓機能の向上
が伴わず、特に冬場、或は高地のようにブロイラーの酸
素要求量が高まる条件下では、心臓に負担がかかり、心
不全から腹水症を併発するという現象が知られるように
なってきた。2. Description of the Related Art In the broiler industry, in order to increase the productivity of broilers quickly and greatly in order to improve productivity,
We have been researching and developing breeding and breeding methods for the strains used. However, as a result of these researches and developments, the gain rate of broiler increased significantly, but this increase rate was not accompanied by the improvement of heart function, and the oxygen demand of broiler increased especially in winter or high altitude. Under the condition, it has become known that the heart is burdened and heart failure is accompanied by ascites.

【０００３】この腹水症の発生は、ブロイラーの育成率
の低下、増体重の減少という弊害を招き、１９７８年頃
から問題視され始め、今なおこれが、ブロイラー産業に
とっては、大きな経済的打撃となっている。[0003] The occurrence of ascites causes adverse effects such as a lower broiler breeding rate and a lower weight gain, and has started to be regarded as a problem from around 1978. Even now, this is a great economic blow to the broiler industry. There is.

【０００４】従来、このような腹水症を防止するため
に、ブロイラーの酸素要求量が高まらないようにするた
めに、鶏舎の構造を変えたり、冬場の温度管理を適切に
行う等の対策がなされているが、これらはコストがかか
り、経済的に負担が大きいという問題を抱えている。Conventionally, in order to prevent such ascites, measures have been taken such as changing the structure of the poultry house and appropriately controlling the temperature in winter in order to prevent the oxygen demand of the broiler from increasing. However, they have a problem that they are costly and economically heavy.

【０００５】そこで、より経済的、直接的にブロイラー
に働きかけて、腹水症を防止するようなブロイラー用腹
水症防止剤の開発が望まれているが、腹水症に効果的な
薬剤は未だ知られていない。Therefore, there has been a demand for the development of an ascites-preventing agent for broilers that acts on the broiler more economically and directly to prevent ascites, but a drug effective for ascites is still unknown. Not not.

【０００６】ところで、キノン類、例えばユビキノン
（補酵素Ｑとも呼ばれる）は、従来より、ブロイラー用
飼料に添加、給与するという試みがなされている。例え
ば、英国特許公告第９１８４０９号には、飼育の最初の
５週間、補酵素Ｑ2〜Ｑ10をブロイラー飼育飼料に１〜
１００ｍｇ／ｋｇ添加して給与し、増体重を向上させる
という報告がある。また、特開昭５０−８２２１９号に
は、α−トコフェロールと補酵素Ｑ7の合剤が産卵率を
向上させるという報告がなされている。By the way, quinones, such as ubiquinone (also called coenzyme Q), have been conventionally tried to be added to and fed to broiler feed. For example, British Patent Publication No. 918409 discloses that for the first 5 weeks of breeding, coenzymes Q 2 to Q 10 are added to the broiler breeding feed in an amount of 1 to 1.
There is a report that 100 mg / kg is added to feed and improve weight gain. In addition, JP-A-50-82219 reports that a combination of α-tocopherol and coenzyme Q 7 improves the egg laying rate.

【０００７】しかし、これらは各々、腹水症が問題視さ
れる以前のものであり、ブロイラーの増体重、または産
卵率の向上作用に基づくものであって、ブロイラー腹水
症に対する防止作用に関わるものではない。However, each of these is before the problem of ascites, and is based on the effect of increasing the weight of broilers or improving the egg laying rate, and does not relate to the effect of preventing broiler ascites. Absent.

【０００８】[0008]

【発明が解決しようとする課題】本発明は、上記観点か
らなされたものであり、ブロイラーの腹水症を有効に防
止し、育成率を向上させることができる薬剤及び飼料を
提供することを課題とする。SUMMARY OF THE INVENTION The present invention has been made from the above viewpoint, and it is an object of the present invention to provide a drug and a feed which can effectively prevent ascites disease of broilers and improve the growth rate. To do.

【０００９】[0009]

【課題を解決するための手段】本発明者は、上記課題を
解決するために鋭意研究を重ねた結果、キノン類をブロ
イラーに投与すると、ブロイラーの腹水症を未然に防
ぎ、育成率を促進することを見出し、本発明を完成する
に至った。Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventor has shown that when quinones are administered to broilers, ascites of broilers is prevented and growth rate is promoted. This has led to the completion of the present invention.

【００１０】すなわち本発明は、化２で表されるキノン
類を有効成分として含有するブロイラー用腹水症防止剤
である。That is, the present invention is an ascites-preventing agent for broilers containing the quinones represented by Chemical formula 2 as an active ingredient.

【００１１】[0011]

【化２】 ただし、化２中、Ｙ及びＺはＨ、ＣＨ3、あるいはＣ1と
Ｃ2の間の二重結合の一方の共有結合を表し、ｎは１〜
１１の整数を表す。本発明はまた、前記キノン類を有効
成分として含有するブロイラー用育成率向上剤、更にこ
れらのブロイラー用腹水症防止剤及びブロイラー用育成
率向上剤から選ばれる１種または２種以上を配合したブ
ロイラー用飼料を提供する。さらに本発明は、前記キノ
ン類を含有する組成物を、キノン類の量として１日当た
り０．０５〜５０ｍｇ／ｋｇ体重の割合でブロイラーに
投与することにより、ブロイラーの腹水症を防止し、育
成率を向上させる方法を提供する。[Chemical 2] However, in Chemical formula 2, Y and Z represent H, CH 3 , or one covalent bond of the double bond between C 1 and C 2 , and n is 1 to 1
Represents an integer of 11. The present invention also provides a growth rate improving agent for broilers containing the quinones as an active ingredient, and a broiler containing one or more selected from these ascites disease preventing agents for broilers and growth rate improving agents for broilers. Provide forage. Furthermore, the present invention prevents the ascites disease of the broiler by administering the composition containing the quinone to the broiler at a rate of 0.05 to 50 mg / kg of body weight per day as the amount of the quinone, thereby preventing the growth rate. Provide a way to improve.

【００１２】尚、本発明において「育成率向上」とは、
育成中の斃死率を減少させ、生育個体の割合を増加させ
ることをいう。以下、本発明を詳細に説明する。本発明
のブロイラー用腹水症防止剤あるいはブロイラー用育成
率向上剤は、上記化２で表される化合物（以下、単に
「キノン類」という）の１種あるいは２種以上を有効成
分として含有する。キノン類のうち、上記化２中におい
てＹ及びＺがＣ1とＣ2の間の共有結合を表し、Ｃ1Ｃ2間
に二重結合を有するユビキノンが好ましく、更にそのう
ちｎが８である補酵素Ｑ9及び化２中ｎが９である補酵
素Ｑ1 0が本発明においては、特に好ましい。In the present invention, "improvement of growth rate" means
This means reducing the mortality rate during breeding and increasing the proportion of growing individuals. Hereinafter, the present invention will be described in detail. The ascites-preventing agent for broilers or the growth rate improving agent for broilers of the present invention contains, as an active ingredient, one or more of the compounds represented by the above Chemical Formula 2 (hereinafter, simply referred to as “quinones”). Among the quinones, ubiquinone in which Y and Z in the above Chemical Formula 2 represent a covalent bond between C 1 and C 2 and has a double bond between C 1 and C 2 is preferable, and n is 8 coenzyme Q 1 0 enzyme Q 9 and of 2 in which n is 9 in the present invention, particularly preferred.

【００１３】ユビキノンは、ムコール属、モルティエラ
属等の糸状菌類、キャンディダ属、サッカロマイセス属
等の酵母類、シュードモナス属、アクロモバクター属、
ロドシュードモナス属等の細菌類、あるいはタバコの
葉、トウモコロシ油、麦芽油等のユビキノン含有物から
抽出、精製して得られる。また、キノン類は化学合成に
よって得ることもでき、市販されてものを使用してもよ
い。Ubiquinone includes filamentous fungi such as Mucor and Mortierella, yeasts such as Candida and Saccharomyces, Pseudomonas, and Achromobacter.
It can be obtained by extraction and purification from bacteria such as Rhodopseudomonas or from ubiquinone-containing substances such as tobacco leaves, peach oil, malt oil and the like. In addition, quinones can be obtained by chemical synthesis, and commercially available products may be used.

【００１４】本発明のブロイラー用腹水症防止剤、及び
ブロイラー用育成率向上剤の剤型は特に限定されず、キ
ノン類の１種又は２種以上の混合物そのものでもよく、
これらを飼育上無害な希釈剤、担体、賦形剤等とともに
組成物として用いてもよい。また、上記のようなキノン
類含有物からの粗精製物、あるいはキノン類含量が高い
場合はキノン類含有物をそのまま使用してもよい。これ
らを通常ブライラーの飼育に用いる飼料に配合すること
により、本発明のブロイラー用飼料が得られる。The dosage forms of the ascites-preventing agent for broilers and the growth rate improving agent for broilers of the present invention are not particularly limited, and may be one kind of quinones or a mixture itself of two or more kinds,
These may be used as a composition together with diluents, carriers, excipients and the like that are harmless to breeding. Further, the crude product obtained from the above-mentioned quinone-containing material or the quinone-containing material may be used as it is when the quinone content is high. The broiler feed of the present invention can be obtained by adding these to the feed usually used for breeding broilers.

【００１５】上記ブロイラー用腹水症防止剤、ブロイラ
ー用育成率向上剤、あるいはブロイラー用飼料の投与方
法としては、経口、非経口のいずれも選択できるが、経
口投与が好ましい。投与量は、経口投与では、キノン類
の量として、１日当たり０．０５〜５０ｍｇ／ｋｇ体重
の割合で投与すると、所期の効果が期待できる。投与時
期と期間に関しても、特に限定されるものではないが、
４週令以後のブロイラーに投与するとより効果的であ
り、４週間以上継続投与すると特に効果的である。As a method of administering the ascites-preventing agent for broilers, the growth rate improving agent for broilers, or the feed for broilers, either oral or parenteral can be selected, but oral administration is preferred. With regard to the dose, in oral administration, the desired effect can be expected when the amount of quinones is 0.05 to 50 mg / kg body weight per day. The administration time and period are not particularly limited, either.
It is more effective when administered to broilers after 4 weeks of age, and particularly effective when administered continuously for 4 weeks or more.

【００１６】また、本発明のブロイラー用腹水症防止
剤、ブロイラー用育成率向上剤、及びブロイラー用飼料
を用いることができるブロイラーの鶏種は、特に限定さ
れない。The broiler chicken species which can use the ascites disease preventing agent for broilers, the growth rate improving agent for broilers, and the feed for broilers of the present invention are not particularly limited.

【００１７】[0017]

【作用】ブロイラーの酸素要求量が高まると、ヘマトク
リット値が増大し、心臓のエネルギー要求性が高まり、
心臓うっ血を起こし腹水症を併発する。本発明のブロイ
ラー用腹水症防止剤等をブロイラー、特に酸素要求量の
高いブロイラーに投与すると、この心臓のエネルギー要
求性を充足し、腹水症を防止し、その結果育成率を向上
すると推測される。[Function] When the oxygen demand of the broiler increases, the hematocrit value increases and the energy demand of the heart increases,
It causes cardiac congestion and concurrent ascites. When the agent for ascites for broiler of the present invention is administered to a broiler, especially a broiler with a high oxygen demand, it is presumed that the energy requirement of the heart is satisfied, ascites is prevented, and as a result, the growth rate is improved. .

【００１８】[0018]

【実施例】以下に、本発明の実施例を説明する。EXAMPLES Examples of the present invention will be described below.

【００１９】[0019]

【実施例１】初めに、ブロイラー用腹水症防止剤、ブロ
イラー用育成率向上剤及びブロイラー用飼料の実施例と
して、ユビキノンを配合した飼料を説明する。[Example 1] First, as an example of an ascites-preventing agent for broilers, a growth rate improving agent for broilers, and a feed for broilers, feed containing ubiquinone will be described.

【００２０】表１に示す成分を混合して、補酵素Ｑ9を
全飼料量に対して２０ｐｐｍ含有するブロイラー用腹水
症防止剤を製造した。同様にして、比較例として、補酵
素Ｑの代わりにα−トコフェロールを含有した飼料を製
造した。The ingredients shown in Table 1 were mixed to prepare an ascites inhibitor for broilers containing 20 ppm of coenzyme Q 9 based on the total feed amount. Similarly, as a comparative example, a feed containing α-tocopherol instead of coenzyme Q was produced.

【００２１】[0021]

【表１】 [Table 1]

【００２２】尚、上記表１中、ビタミンＡＤＥ剤は、ビ
タミンＡを１００００ＩＵ／ｇ、ビタミンＤ3を２００
０ＩＵ／ｇ、ビタミンＥを１０ＩＵ／ｇ含有し、ビタミ
ンＢ剤は、ビタミンＢ1を２ｇ／ｋｇ、ビタミンＢ2を１
０ｇ／ｋｇ、ビタミンＢ6を２ｇ／ｋｇ、ニコチン酸ア
ミドを２ｇ／ｋｇ、パントテン酸カルシウムを４ｇ／ｋ
ｇ、塩化コリンを１２０ｇ／ｋｇ、ヨウ酸を１ｇ／ｋｇ
含有する。また、微量ミネラルは、Ｍｎを８．０％、Ｆ
ｅを０．６％、Ｃｕを０．０６％、Ｉを０．１％、Ｚｎ
を５．０％含有している。尚、サリノマイシンは抗コク
シジウム剤、バージニアマイシンは抗生物質である。In Table 1, the vitamin ADE agent contains 10000 IU / g vitamin A and 200 vitamin D 3 .
0 IU / g, the vitamin E contained 10 IU / g, vitamin B agent, vitamin B 1 2 g / kg, vitamin B 2 1
0 g / kg, vitamin B 6 2 g / kg, nicotinamide 2 g / kg, calcium pantothenate 4 g / k
g, choline chloride 120 g / kg, iodic acid 1 g / kg
contains. The trace minerals are Mn 8.0%, F
0.6% e, 0.06% Cu, 0.1% I, Zn
5.0% is contained. Salinomycin is an anticoccidial agent and Virginiamycin is an antibiotic.

【００２３】[0023]

【実施例２】次に、腹水症を防止し、育成率を向上させ
る方法の実施例を説明する。上記実施例１及び比較例１
の飼料をブロイラーに投与し、本発明のブロイラー用腹
水症防止剤及び腹水症を防止する方法の評価を行った。Example 2 Next, an example of a method for preventing ascites and improving the growth rate will be described. Example 1 and Comparative Example 1
The ascites preventive agent for broilers of the present invention and the method for preventing ascites were evaluated by administering the above feed to a broiler.

【００２４】＜投与方法＞１群１００羽づつの１日令の
雄肉用鶏を、ウィンドレス鶏舎で、５６日間飼育した。
飼育条件としては、育雛温度を、腹水症を誘発しやすい
ような条件、つまり、飼育開始後１４日目〜２１日目ま
では寒冷感作期間として５℃以下、他の期間は２１〜２
６℃の範囲に設定し、管理した。飼育期間中の温度を表
２に示す。<Administration Method> One-day-old male chickens of 100 chickens per group were bred in a windless poultry house for 56 days.
As for the breeding conditions, the temperature for raising chicks is a condition that easily induces ascites, that is, a cold sensitization period of 5 ° C. or lower from 14th to 21st days after the start of breeding, and 21 to 2 at other periods.
It was set and controlled within the range of 6 ° C. Table 2 shows the temperature during the breeding period.

【００２５】[0025]

【表２】 [Table 2]

【００２６】飼料は、最初の２１日間は、全てのブロイ
ラーに表３に示す配合の通常飼料を与え、その後３５日
間は、１群には実施例の飼料を、他の１群には、比較例
の飼料を与えて飼育した。For the first 21 days, all the broilers were fed with the normal feed having the composition shown in Table 3, and for the next 35 days, one group was fed with the feed of the Example and the other one group was compared with the feed. The animals were fed with the example feed.

【００２７】[0027]

【表３】 尚、上記表３中、ビタミンＡＤＥ剤、ビタミンＢ剤、微
量ミネラルは、前記実施例１と同じものを用いた。[Table 3] In Table 3, the same vitamin ADE agent, vitamin B agent, and trace minerals as those used in Example 1 were used.

【００２８】＜評価＞ 飼育期間中に死亡したブロイラーに関しては死亡原因を
調査し、各群での腹水症の発生率を求めた。飼育期間終
了後、それぞれの群で、生存しているブロイラーの数を
調べて育成率を求めた。また、体重を測定してその平均
値を求めるとともに、飼育期間中、記録しておいた飼料
摂取量について、その体重当りの値を求め、これを飼料
要求率とした。以上の値について両群を比較した結果を
表４に示す。<Evaluation> For broilers that died during the breeding period, the cause of death was investigated, and the incidence of ascites in each group was determined. After the breeding period was completed, the number of surviving broilers in each group was examined to determine the breeding rate. In addition, the body weight was measured and the average value thereof was calculated, and the value of the feed intake recorded during the rearing period was calculated for each body weight, which was used as the feed conversion rate. Table 4 shows the results of comparing the two groups with respect to the above values.

【００２９】[0029]

【表４】 [Table 4]

【００３０】この結果から明らかなように、本発明のブ
ロイラー用腹水症防止剤を投与されたブロイラーは、α
−トコフェロールを投与されたブロイラーに比べて、腹
水症の発生率が非常に少なく、育成率も高い。また少な
い飼料で効果的に増体重している。As is clear from these results, the broilers to which the ascites-preventing agent for broilers of the present invention was administered showed α
-The incidence of ascites is very low and the breeding rate is high compared to broilers administered tocopherol. Also, he gains weight effectively with less feed.

【００３１】[0031]

【発明の効果】本発明のブロイラー用腹水症防止剤は、
ブロイラーの腹水症を有効に防止し、育成率を向上さ
せ、また成長促進効果および飼料効率の改善も可能とす
る。The ascites preventive agent for broilers of the present invention comprises:
Ascites of broilers can be effectively prevented, the growth rate can be improved, and the growth promoting effect and feed efficiency can be improved.

───────────────────────────────────────────────────── フロントページの続き (56)参考文献 特開 昭50−82219（ＪＰ，Ａ) 英国特許918409（ＧＢ，Ｂ) 五十嵐俊二，Ｄｅｓｏｘｙｃｏｒｔｉ ｃｏｓｔｅｒｏｎｅ ａｃｅｔａｔｅ− 食塩負荷ラットの高血圧症心血管症に対 するＣｏｅｎｚｙｍｅＱ10の作用，日本 薬理学雑誌，1972年，第68巻，第４号, 第460−472頁 石山太朗，うっ血性心不全に対するＣ ｏｅｎｚｙｍｅＱ10の使用経験，診療, 1971年，第24巻，第１号，第92−96頁 西澤芳男，ＣｏｅｎｚｙｍｅＱ（Ｑ 10）の心不全に対する治療効果，臨床と 研究，1981年，第58巻，第12号，第335 （4131）−344（4140）頁 Ｒ． Ｊ． Ｊｕｌｉａｎ，肉用鶏の 右心室障害と腹水症の原因：肺動脈高血 圧症，科学飼料，1990年，第36巻，第１ 号，第７−８頁 (58)調査した分野(Int.Cl.7，ＤＢ名) A61K 31/12 A61P 9/04 A61P 43/00 171 A23K 1/16 301 A23K 1/18 ＣＡ（ＳＴＮ) ＲＥＧＩＳＴＲＹ（ＳＴＮ) ＭＥＤＬＩＮＥ（ＳＴＮ)─────────────────────────────────────────────────── ─── Continuation of the front page (56) References JP-A-50-82219 (JP, A) British Patent 918409 (GB, B) Shunji Igarashi, Desoxycorti costone acetate- Hypertensive cardiovascular disease of salt-loaded rats. Action of Coenzyme Q10, Japanese Pharmacological Journal, 1972, Volume 68, No. 4, pages 460-472 Taro Ishiyama, Experience of using Coenzyme Q10 for congestive heart failure, Medical treatment, 1971, Volume 24, No. 1 , Pp. 92-96, Yoshio Nishizawa, Therapeutic effect of Coenzyme Q (Q10) on heart failure, Clinical and research, 1981, 58, No. 12, 335 (4131) -344 (4140) R. et al. J. Julian, Cause of Right Ventricular Disorder and Ascites in Chickens: Pulmonary Artery Hypertension, Scientific Feed, 1990, Vol. 36, No. 1, pp. 7-8 (58) Fields investigated (Int.Cl. 7 , DB name) A61K 31/12 A61P 9/04 A61P 43/00 171 A23K 1/16 301 A23K 1/18 CA (STN) REGISTRY (STN) MEDLINE (STN)

Claims (5)

(57)【特許請求の範囲】(57) [Claims] 【請求項１】 少なくとも４週齢であるブロイラーに、化
１で表される少なくとも一つのキノン類を有効成分とし
て含有する組成物を投与することを特徴とするブロイラ
ーの腹水症を防止する方法。 【化１】 ただし、化１中、Ｙ及びＺはＨ、ＣＨ3、あるいはＣ1と
Ｃ2の間の二重結合の一方の共有結合を表し、ｎは１〜
１１の整数を表す。 1. A method for preventing ascites in broilers, which comprises administering to a broiler that is at least 4 weeks old a composition containing at least one quinone represented by Chemical formula 1 as an active ingredient. [Chemical 1] However, in chemical formula 1, Y and Z represent H, CH 3 , or one covalent bond of the double bond between C 1 and C 2 , and n is 1 to 1
Represents an integer of 11. 【請求項２】 前記化１で表される少なくとも一つのキ
ノン類を有効成分として含有する組成物を、キノン類の
量として１日当たり０．０５〜５０ｍｇ／ｋｇ体重の割
合でブロイラーに投与する、請求項１に記載のブロイラ
ーの腹水症を防止する方法。 2. A composition containing at least one quinone represented by the chemical formula 1 as an active ingredient is administered to a broiler at an amount of quinones of 0.05 to 50 mg / kg body weight per day. A method for preventing ascites from the broiler of claim 1. 【請求項３】 前記化１で表される少なくとも一つのキ
ノン類を有効成分として含有する組成物が、飼料に混合
されブロイラーに投与される、請求項１に記載のブロイ
ラーの腹水症を防止する方法。 3. The ascites disease of the broiler according to claim 1, wherein the composition containing at least one quinone represented by the chemical formula 1 as an active ingredient is mixed with feed and administered to the broiler. Method. 【請求項４】 前記化１で表される少なくとも一つのキ
ノン類を有効成分として含有する組成物が、少なくとも
４週齢であるブロイラーに対し４週間以上継続投与す
る、請求項１に記載のブロイラーの腹水症を防止する方
法。 4. A composition comprising at least one quinones represented by Formula 1 as an active ingredient, continue administered over 4 weeks to broilers at least 4 weeks of age, broilers according to claim 1 To prevent ascites in people. 【請求項５】 前記化１中、ｎが８または９である、請
求項１に記載のブロイラーの腹水症を防止する方法。Among wherein said reduction 1, n is 8 or 9, a method for preventing ascites of broilers according to claim 1.
JP07724793A 1993-04-02 1993-04-02 Ascites inhibitor for broiler and method for preventing ascites Expired - Lifetime JP3515140B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP07724793A JP3515140B2 (en) 1993-04-02 1993-04-02 Ascites inhibitor for broiler and method for preventing ascites
PCT/JP1994/000519 WO1994022433A1 (en) 1993-04-02 1994-03-30 Broiler ascites preventive and method of preventing ascites
CN94192212A CN1101186C (en) 1993-04-02 1994-03-30 Broiler ascites preventive and method of preventing ascites
AU62919/94A AU6291994A (en) 1993-04-02 1994-03-30 Broiler ascites preventive and method of preventing ascites

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP07724793A JP3515140B2 (en) 1993-04-02 1993-04-02 Ascites inhibitor for broiler and method for preventing ascites

Publications (2)

Publication Number Publication Date
JPH06287136A JPH06287136A (en) 1994-10-11
JP3515140B2 true JP3515140B2 (en) 2004-04-05

Family

ID=13628536

Family Applications (1)

Application Number Title Priority Date Filing Date
JP07724793A Expired - Lifetime JP3515140B2 (en) 1993-04-02 1993-04-02 Ascites inhibitor for broiler and method for preventing ascites

Country Status (4)

Country Link
JP (1) JP3515140B2 (en)
CN (1) CN1101186C (en)
AU (1) AU6291994A (en)
WO (1) WO1994022433A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0913095A4 (en) * 1996-07-08 2000-02-23 Tomoya Aoyama Feed composition for poultry
JP2002223708A (en) * 1997-05-14 2002-08-13 Idemitsu Material Kk Feed composition for broiler and method for rearing broiler
US5977185A (en) * 1998-08-11 1999-11-02 Rta Associates, Inc. Method for prevention and treatment of production disease of genetically improved livestock and poultry
EP2398339B1 (en) * 2009-02-20 2014-09-03 RiboCor, Inc. Compositions and methods for feeding poultry
EP2572589A4 (en) 2010-05-21 2014-04-16 Kaneka Corp Pig feed, and method for feeding same
JPWO2016024344A1 (en) * 2014-08-13 2017-05-18 日清ファルマ株式会社 Method for producing livestock and method for promoting growth of livestock

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5721319A (en) * 1980-07-15 1982-02-04 Zeria Shinyaku Kogyo Kk Agent for improving desorder of circulatory orgen
CH661443A5 (en) * 1984-11-22 1987-07-31 Seuref Ag Pharmaceutical compositions having metabolic activity

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Ｒ． Ｊ． Ｊｕｌｉａｎ，肉用鶏の右心室障害と腹水症の原因：肺動脈高血圧症，科学飼料，１９９０年，第３６巻，第１号，第７−８頁
五十嵐俊二，Ｄｅｓｏｘｙｃｏｒｔｉｃｏｓｔｅｒｏｎｅ ａｃｅｔａｔｅ−食塩負荷ラットの高血圧症心血管症に対するＣｏｅｎｚｙｍｅＱ１０の作用，日本薬理学雑誌，１９７２年，第６８巻，第４号，第４６０−４７２頁
石山太朗，うっ血性心不全に対するＣｏｅｎｚｙｍｅＱ１０の使用経験，診療，１９７１年，第２４巻，第１号，第９２−９６頁
西澤芳男，ＣｏｅｎｚｙｍｅＱ（Ｑ１０）の心不全に対する治療効果，臨床と研究，１９８１年，第５８巻，第１２号，第３３５（４１３１）−３４４（４１４０）頁

Also Published As

Publication number Publication date
CN1101186C (en) 2003-02-12
WO1994022433A1 (en) 1994-10-13
AU6291994A (en) 1994-10-24
CN1124453A (en) 1996-06-12
JPH06287136A (en) 1994-10-11

Similar Documents

Publication Publication Date Title
EP0532369A2 (en) Furth therapeutical uses of L-methionine and compositions
EP1031287A1 (en) Drinking water additive for birds and method of administering the same
JP3515140B2 (en) Ascites inhibitor for broiler and method for preventing ascites
US3800051A (en) Reducing serum cholesterol with certain substituted phenols
US4110446A (en) Method of treating milk fever in dairy cattle with 1,25-dihydroxycholecalciferol
Bird The influence of ingested estrogens on feed intake, metabolic rate and lipemia in male fowl
US4937077A (en) Method for improving feed conversion of meat-producing animals by oral administration of 2-deoxy-D-hexose
US3367830A (en) Controlling coccidiosis in poultry with 1,4-naphthoquinones
Culik et al. Vitamin E deficiency in the lamb
JPH08500602A (en) Composition for maintaining and / or increasing muscle strength and somatic cell mass
DE2323906A1 (en) PHARMACEUTICAL PREPARATION AGAINST OBESITY
EP0279290A2 (en) Anticoccidial agent
DE69230590T2 (en) AGENT AGAINST OBESITY
JPH07188009A (en) Anti-coccidium composition
JPH07123928A (en) Agent for preventing poultry disease and feed for poultry
US5985845A (en) Methods for reducing mortality rates in poultry
Drew et al. Compensatory growth and reproductive performance in young sheep given differential nutrition from 9 to 13 months of age
US4659713A (en) Quinoxalinedione compounds useful for controlling coccidiosis
DE2759108A1 (en) USE OF ALPHA -MERCAPTO-BETA-ARYL-ACRYLIC ACIDS IN INCREASING THE ZINC CONTENT IN SERUM AND TISSUE
US4034110A (en) Anthelmintics effective against liver flukes
Bortree et al. Ascorbic acid stimulation in the blood plasma of dairy cattle produced by the ingestion of chlorobutanol
US5951998A (en) Ascites-preventive agent and ascites-preventive method for broilers
JP2784071B2 (en) Chicken feed
EP0087744B1 (en) Lipid metabolism improving agents
EP1143945B1 (en) Carnitine supplemented diet to prevent sudden death syndrome in broiler breeder type poultry

Legal Events

Date Code Title Description
A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20040115

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313111

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090123

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090123

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100123

Year of fee payment: 6

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100123

Year of fee payment: 6

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110123

Year of fee payment: 7

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120123

Year of fee payment: 8

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130123

Year of fee payment: 9

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140123

Year of fee payment: 10