JP3339650B2 - Liquid dispensing device - Google Patents
Liquid dispensing deviceInfo
- Publication number
- JP3339650B2 JP3339650B2 JP18864293A JP18864293A JP3339650B2 JP 3339650 B2 JP3339650 B2 JP 3339650B2 JP 18864293 A JP18864293 A JP 18864293A JP 18864293 A JP18864293 A JP 18864293A JP 3339650 B2 JP3339650 B2 JP 3339650B2
- Authority
- JP
- Japan
- Prior art keywords
- liquid
- liquid storage
- dispensing
- metering pump
- gas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Description
【０００１】[0001]
【産業上の利用分野】この発明は、大学、病院等の理化
学検査、臨床検査等に於いて、試薬を分注、混合するの
に使用する液体分注装置に係り、詳記すれば、複数の液
体分注部を独立して制御し得るようにした液体分注装置
に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid dispensing apparatus used for dispensing and mixing reagents in physicochemical examinations, clinical examinations, etc. of universities and hospitals. The present invention relates to a liquid dispensing device capable of independently controlling a liquid dispensing section.
【０００２】[0002]
【従来の技術】液体の分注に於いて、定量ポンプを使用
し、エア−を介して一定量の液体を吸引し、これを分注
する液体分注装置は、特に接触不安定な液体、高価な液
体等の分注に大学、病院等で広く使用されている。この
ような分注装置としては、従来図８に示すように、操作
の簡便化と処理速度の向上を目的として、４連、８連、
１２連等の定量ポンプ（図示せず）にピペット１をそれ
ぞれ接続し、全てのピペット１から試薬槽２の液体を同
時に吸入し、これをプレート３のウエル４内に同時に分
注する装置が知られていた。2. Description of the Related Art In dispensing liquids, a liquid dispensing apparatus which sucks a certain amount of liquid through air using a metering pump and dispenses the liquid is particularly a liquid which is unstable in contact. It is widely used in universities, hospitals, etc. for dispensing expensive liquids. Conventionally, as shown in FIG. 8, such a dispensing apparatus has four, eight and four stations for the purpose of simplifying operation and improving processing speed.
A device is known in which pipettes 1 are respectively connected to 12 or more metering pumps (not shown), and the liquid in reagent tank 2 is simultaneously sucked from all pipettes 1 and dispensed into wells 4 of plate 3 at the same time. Had been.
【０００３】しかしながら、上記分注装置は、複数の定
量ポンプは備えているものの、その制御部及び駆動部は
１個であったので、定量ポンプ毎に分注の可否を決定す
ることができないという問題があった。そのため、必然
的に試薬は全てのピペット１から試薬がウエル４内に分
注されるが、試薬が分注されたウエル４（ピペット１の
数だけある）の全てにピペット１からの試薬と反応させ
るべき検体が充填されているとは限らないので、充填さ
れていない場合は、ウエル４内に分注された試薬は全く
の無駄となる。この種分注に使用する試薬は一般に高価
なものが多いので、そのまま廃棄するのは極めて不経済
であるが、さりとて検体の充填されていないウエル４の
みから試薬を回収しようとすると、迅速な処理操作の妨
げになるという新たな問題が生じる。[0003] However, although the dispensing apparatus has a plurality of metering pumps, it has only one control unit and one driving unit, so that it is not possible to determine whether dispensing can be performed for each metering pump. There was a problem. Therefore, the reagent is inevitably dispensed from all the pipettes 1 into the wells 4. However, all of the wells 4 (the number of which is equal to the number of the pipettes 1) into which the reagent has been dispensed react with the reagent from the pipette 1. The sample to be caused is not always filled, and if not filled, the reagent dispensed into the well 4 is completely wasted. Since many reagents used for this kind of dispensing are generally expensive, it is extremely uneconomical to discard the reagents as they are. However, if the reagents are to be recovered only from the wells 4 not filled with the sample, a rapid processing is required. A new problem arises that hinders operation.
【０００４】また、上記分注装置を使用して測定を行っ
た場合には、一連の測定を同一マイクロプレ−ト上で効
率よく実施できないという問題が生じる場合が多い。即
ち、検体中の特定の抗原や抗体の力価の検定は、種々の
希釈倍率の検体を順次ウエル４内に充填して抗原抗体反
応が検出されなくなる希釈倍率を求めることにより行う
が、初めに準備した希釈倍率まででは陽性の結果しか得
られず、更に希釈した検体を用いて追加実験を行う必要
が生じる場合が多い。この場合、目的の倍率に希釈した
検体を、既に実施済みの検体希釈列のウエル４の隣のウエ
ル４から順次充填できれば、一連の結果が一目で判るの
で好ましいことは明らかであるが、上記分注装置を使用
した場合は、該ウエル４には既に試薬が分注されている
ので、改めて希釈検体を充填することはできないという
問題が生じるのである。検体と試薬の分注の順序を守ら
ないと測定が不可能であるからである。[0004] When measurement is performed using the above-mentioned dispensing apparatus, a problem often arises that a series of measurements cannot be efficiently performed on the same microplate. That is, the assay of the titer of a specific antigen or antibody in the sample is performed by sequentially filling the sample with various dilution factors into the well 4 and determining the dilution factor at which the antigen-antibody reaction is not detected. Up to the prepared dilution ratio, only a positive result can be obtained, and it is often necessary to perform an additional experiment using a further diluted sample. In this case, it is clear that it is preferable that the sample diluted to the target magnification can be sequentially filled from the well 4 adjacent to the well 4 in the already-executed sample dilution row, since a series of results can be seen at a glance. When the injection device is used, since the reagent has already been dispensed into the well 4, there is a problem that the diluted sample cannot be filled again. This is because the measurement cannot be performed unless the order of dispensing the sample and the reagent is observed.
【０００５】上記多連定量ポンプのポンプ毎に分注の可
否を決定するには、ポンプ毎にポンプの制御部と駆動部
を設ければ良いわけであるが、このことは必然的に装置
を長大化させ、装置も複雑高価となるので実用化されて
いない。そのため、従来、ポンプ毎に分注の可否を決定
する分注装置は、市販されていないし、知られていな
い。ピペットが１個のシングルピペットであれば、上記
したような同時分注に伴う問題は生じないが、これでは
高速処理の要請を満たすことはできない。In order to determine whether or not dispensing can be performed for each pump of the multiple metering pump, it is sufficient to provide a pump control unit and a driving unit for each pump. It has not been put to practical use because of its length and the equipment becomes complicated and expensive. For this reason, a dispensing device that determines whether or not dispensing can be performed for each pump is not commercially available or known. If the single pipette is a single pipette, the above-described problem of simultaneous dispensing does not occur, but this cannot satisfy the demand for high-speed processing.
【０００６】[0006]
【発明が解決しようとする課題】この発明は、このよう
な点に着目してなされたものであり、簡単な方法によ
り、多連定量ポンプのポンプ毎に分注の可否を決定する
ことができ、しかも高速処理することができる分注装置
を提供することを目的とする。SUMMARY OF THE INVENTION The present invention has been made in view of such a point, and it is possible to determine whether or not dispensing can be performed for each pump of a multiple metering pump by a simple method. It is another object of the present invention to provide a dispensing apparatus capable of performing high-speed processing.
【０００７】[0007]
【課題を解決するための手段】上記目的に沿う本発明の
構成は、定量ポンプのガス圧によって、該定量ポンプに
接続した貯液部への試液の吸入と貯液部からの試液の排
出を行う液体分注装置に於いて、前記定量ポンプと前記
貯液部とで１組を構成する液体分注部を複数組設け、前
記定量ポンプと前記貯液部との間に自動バルブを配設
し、前記複数の定量ポンプによるガスの吸入若しくは排
出を同時に行いながら、前記自動バルブによりガスを前
記貯液部に導入するか、或は前記貯液部外に排出するか
の制御と、ガスを前記貯液部から吸入するか、或は前記
貯液部外から吸入するかを制御することによって、前記
貯液部への試液の吸入と貯液部からの試液の分注を独立
して制御し得るようにしたことを特徴とする。According to the present invention, which is directed to the above object, the gas pressure of the metering pump causes the sample solution to be sucked into and discharged from the liquid reservoir connected to the metering pump.
In the liquid dispensing device that performs the dispensing, a plurality of sets of liquid dispensing units forming one set by the metering pump and the liquid storage unit are provided, and an automatic valve is provided between the metering pump and the liquid storage unit. Arranged, while simultaneously performing the suction or discharge of gas by the plurality of metering pumps, controlling whether the automatic valve introduces gas into the liquid storage unit or discharges the gas outside the liquid storage unit, or inhalation of gas from the reservoir, or by controlling whether the suction from the reservoir outer, the
It is characterized in that it is possible to independently control the inhalation of the test liquid into the liquid storage section and the dispensing of the test liquid from the liquid storage section .
【０００８】[0008]
【実施例】次に、本発明の実施例を図面に基づいて説明
する。図１は、８連液体分注装置の概略図を示すもので
あり、小型パルスモータ１２により駆動される定量ポン
プ１３と貯液部（ピペット）１６との間に、エア−の前
記貯液部１６への導入若しくは貯液部１６からの吸入
と、エア−の前記貯液部１６外への排出若しくは貯液部
外からの吸入を制御する三方電磁弁１４とを配設し、前
記モータ１２と三方電磁弁１４とを制御器１１により制
御し得るように構成した例を示す。Next, an embodiment of the present invention will be described with reference to the drawings. FIG. 1 is a schematic view of an eight-stage liquid dispensing apparatus, in which a liquid storage section (air) is provided between a metering pump 13 driven by a small pulse motor 12 and a liquid storage section (pipette) 16. A three-way solenoid valve 14 for controlling the introduction into or suction from the liquid reservoir 16 and the discharge of air out of the liquid reservoir 16 or the suction from outside the liquid reservoir; An example is shown in which the controller 11 and the three-way solenoid valve 14 can be controlled by the controller 11.
【０００９】定量ポンプ１３は、モ−タ１２によりギヤ
−１５を回動させ、ギヤ−１５と歯合するラックギヤ−
２０を上下動させて、シリンダ−２１内のピストン棒１
７を上下動させることによりエア−の吸排出を行い、エ
アーの吸排出に連動して、貯液部１６からの液体の吸排
出若しくは三方電磁弁１４からのエア−の吸排出を行う
ことができるようになっている。本発明に於いては、定
量ポンプ１３は、ガスの吸排出によって、貯液部１６内
の液体の吸排出を制御し得るものであれば良く、特にそ
の種類は限定されない。The metering pump 13 rotates the gear 15 by the motor 12, and the rack gear meshes with the gear 15.
20 is moved up and down to move the piston rod 1 in the cylinder-21.
7 is moved up and down to suck and discharge air, and the suction and discharge of liquid from the liquid storage unit 16 and the suction and discharge of air from the three-way solenoid valve 14 are performed in conjunction with the suction and discharge of air. I can do it. In the present invention, the metering pump 13 is not particularly limited as long as it can control the suction and discharge of the liquid in the liquid storage section 16 by the suction and discharge of the gas.
【００１０】上記実施例に於いては、８連の分注装置を
示したが、複数であるなら特にその数は限定されない。
しかしながら、処理速度の向上には、一般的なマイクロ
プレ−トに好適な４連、８連、１２連等とするのが好ま
しい。上記実施例に於いては、定量ポンプ１３と貯液部
１６との間に、三方電磁弁を１個設けているが、これは
必ずしもこのようでなくともよく、二方電磁弁を２個設
けても三方電磁弁と同様の作用をするので差し支えな
い。三方電磁弁及び二方電磁弁のような自動バルブとし
ては、電磁弁に限らず、例えばエアー駆動式自動バルブ
のような他の自動バルブでもよい。In the above embodiment, eight dispensers are shown, but the number is not particularly limited as long as there are plural dispensers.
However, in order to improve the processing speed, it is preferable to use four, eight, twelve or the like suitable for a general microplate. In the above embodiment, one three-way solenoid valve is provided between the metering pump 13 and the liquid storage part 16, but this is not necessarily required, and two two-way solenoid valves are provided. Even so, the same operation as the three-way solenoid valve is performed, so that no problem is caused. The automatic valve such as the three-way solenoid valve and the two-way solenoid valve is not limited to the solenoid valve, but may be another automatic valve such as an air-driven automatic valve.
【００１１】[0011]
【作用】次に、上記のように構成された本発明の作用を
図２〜図７の２連液体分注装置に基づいて説明する。
尚、図中黒く塗り潰した二方電磁弁は弁を閉じた状態を
示し、白地の二方電磁弁は弁が開いた状態を示す。図２
に示すように、定量ポンプ１３，１３′からエア−を全
量排出し、貯液部１６，１６′内には、液体が存在しな
い状態とする。この際、電磁弁１８，１８′は閉じてお
り、電磁弁１９，１９′は開いている。ついで、貯液部
１６，１６′の先端を液体中に浸し、モ−タ１２により
定量ポンプ１３，１３′のピストン棒１７，１７′を上
昇させて液体を吸入すると、図３に示すように、液体は
貯液部１６，１６′中に充填される。Next, the operation of the present invention constructed as described above will be described with reference to the dual liquid dispensing apparatus shown in FIGS.
In the drawing, the two-way solenoid valve painted black indicates a closed state, and the two-way solenoid valve on a white background indicates the opened state. FIG.
As shown in (1), the entire amount of air is discharged from the metering pumps 13 and 13 'so that no liquid exists in the liquid storage sections 16 and 16'. At this time, the solenoid valves 18, 18 'are closed, and the solenoid valves 19, 19' are open. Next, the tips of the liquid storage sections 16, 16 'are immersed in the liquid, and the piston rods 17, 17' of the metering pumps 13, 13 'are raised by the motor 12 to suck the liquid, as shown in FIG. , The liquid is filled in the liquid storage sections 16, 16 '.
【００１２】貯液部１６，１６′中の液体を同時に分注
する場合は、図４に示すように、電磁弁１８，１８′，
１９，１９′はこのままの状態で、定量ポンプ１３，１
３′のピストン棒１７，１７′を下降させて液体を分注
すればよい。貯液部１６，１６′中の一方の液体を分注
する場合は、図５に示すように、分注する貯液部１６と
の間に配設されている電磁弁１８，１９はこのままの状
態で、分注しない貯液部１６′との間に配設した電磁弁
１８′を開とし、１９′を閉とし、定量ポンプ１３，１
３′のピストン棒１７，１７′を下降させればよい。そ
の結果、貯液部１６中にはエア−が導入されるので、貯
液部１６中の液体は排出されるが、貯液部１６′中には
エア−が導入されずに、エア−は電磁弁１８′から排出
されるので、貯液部１６′中の液体は排出されない。When dispensing the liquids in the liquid storage sections 16, 16 'simultaneously, as shown in FIG. 4, the solenoid valves 18, 18',
19, 19 'are in this state, and the metering pumps 13, 1
The liquid may be dispensed by lowering the 3 'piston rods 17, 17'. When dispensing one of the liquids in the liquid storage sections 16 and 16 ', as shown in FIG. 5, the electromagnetic valves 18 and 19 disposed between the liquid storage sections 16 and 16 to be dispensed are kept as they are. In this state, the solenoid valve 18 ′ disposed between the liquid dispensing part 16 ′ that is not dispensed is opened, the solenoid valve 19 ′ is closed, and the metering pumps 13 and 1 are closed.
The 3 'piston rods 17, 17' may be lowered. As a result, air is introduced into the liquid storage section 16, so that the liquid in the liquid storage section 16 is discharged, but no air is introduced into the liquid storage section 16 ', and the air is discharged. Since the liquid is discharged from the solenoid valve 18 ', the liquid in the liquid storage section 16' is not discharged.
【００１３】図６は、液体を一部分注した後の初期化動
作を示すものであり、貯液部１６，１６′への流路を開
閉する電磁弁１９，１９′を閉とし、大気中への流路を
開閉する電磁弁１８，１８′を開とし、定量ポンプ１
３，１３′のピストン棒１７，１７′を上昇させる。こ
の動作で分注操作に使用した量のエア−を電磁弁１８，
１８′を通じて外部から吸引することができる。図７
は、貯液部１６，１６′中の液体を全量排出させる初期
化動作を示すものであり、貯液部１６，１６′への流路
を開閉する電磁弁１９，１９′を開とし、大気中への流
路を開閉する電磁弁１８，１８′を閉とし、定量ポンプ
１３，１３′のピストン棒１７，１７′を下降させて、
エア−と液体の全量を排出し、図２と同じ状態とし、次
の吸引動作に備える。上記作用に於いて、モ−タ１２及
び電磁弁１８，１８′，１９，１９′の制御は、制御器
１１による公知の方法によって制御されるようになって
いる。FIG. 6 shows an initializing operation after a part of the liquid is poured. The electromagnetic valves 19 and 19 'for opening and closing the flow paths to the liquid storage sections 16 and 16' are closed, and the air is released to the atmosphere. Solenoid valves 18 and 18 'for opening and closing the flow path of
Raise the piston rods 17, 17 'of the 3, 13'. In this operation, the amount of air used for the dispensing operation is supplied to the solenoid valve 18,
It can be sucked from outside through 18 '. FIG.
Shows an initialization operation for discharging the entire amount of the liquid in the liquid storage sections 16 and 16 '. The electromagnetic valves 19 and 19' for opening and closing the flow paths to the liquid storage sections 16 and 16 'are opened, and the atmosphere is released. The electromagnetic valves 18 and 18 'for opening and closing the flow path to the inside are closed, and the piston rods 17 and 17' of the metering pumps 13 and 13 'are lowered,
The entire amount of the air and the liquid is discharged, and the same state as that of FIG. 2 is prepared for the next suction operation. In the above operation, the control of the motor 12 and the solenoid valves 18, 18 ', 19, 19' is controlled by the controller 11 by a known method.
【００１４】[0014]
【効果】以上述べたごとく、本発明によれば、極めて簡
単な構成によって、液体を吸排出する複数の貯液部を独
立して制御し、分注することができるので、マイクロプ
レートのウエル毎に分注することができ、使用する試薬
の無駄が省けて経済的であるというシングルピペットの
利点と、高速処理が可能であるという多連ピペットの利
点とを併有するものであり、この種従来の分注装置には
全く見られなかった顕著な効果を奏する。As described above, according to the present invention, it is possible to independently control and dispense a plurality of liquid storage units for sucking and discharging a liquid with a very simple structure, so that each well of a microplate can be dispensed. The advantage of a single pipette is that it is economical by eliminating waste of reagents to be used, and the advantage of a multiple pipette that enables high-speed processing. Has a remarkable effect which was not seen at all in the dispensing device.
【００１５】[0015]
【図１】本発明の実施例を示す概略断面図である。FIG. 1 is a schematic sectional view showing an embodiment of the present invention.
【図２】本発明の分注装置の初期状態を示す概略断面図
である。FIG. 2 is a schematic sectional view showing an initial state of the dispensing device of the present invention.
【図３】本発明の分注装置に液体を充填した状態を示す
概略断面図である。FIG. 3 is a schematic sectional view showing a state where a liquid is filled in the dispensing apparatus of the present invention.
【図４】本発明の分注装置に充填された液体を同時分注
した状態を示す概略断面図である。FIG. 4 is a schematic sectional view showing a state in which liquid filled in the dispensing device of the present invention is simultaneously dispensed.
【図５】本発明の分注装置の一方の貯液部から液体を分
注した状態を示す概略断面図である。FIG. 5 is a schematic cross-sectional view showing a state where a liquid is dispensed from one liquid storage part of the dispensing device of the present invention.
【図６】本発明の分注装置に於いて、液体を充填した状
態から初期化する状態を示す概略断面図である。FIG. 6 is a schematic cross-sectional view showing a state in which the dispensing apparatus of the present invention is initialized from a state in which a liquid is filled.
【図７】本発明の分注装置に於いて、液体を全て排出し
て初期化する状態を示す概略断面図である。FIG. 7 is a schematic sectional view showing a state in which all liquid is discharged and initialized in the dispensing apparatus of the present invention.
【図８】従来の分注装置を示す斜視図である。FIG. 8 is a perspective view showing a conventional dispensing device.
１１ 制御器 １２ モータ １３，１３′ 定量ポンプ １６，１６′ 貯液部（ピペット） １８，１８′，１９，１９′ 電磁弁 11 Controller 12 Motor 13, 13 'Metering Pump 16, 16' Liquid Reservoir (Pipette) 18, 18 ', 19, 19' Solenoid Valve
フロントページの続き (58)調査した分野(Int.Cl.7，ＤＢ名) G01N 1/00 101 G01N 35/10 ＪＩＣＳＴファイル（ＪＯＩＳ)Continuation of the front page (58) Field surveyed (Int. Cl. 7 , DB name) G01N 1/00 101 G01N 35/10 JICST file (JOIS)
Claims (2)
プに接続した貯液部への試液の吸入と貯液部からの試液
の排出を行う液体分注装置に於いて、前記定量ポンプと
前記貯液部とで１組を構成する液体分注部を複数組設
け、前記定量ポンプと前記貯液部との間に自動バルブを
配設し、前記複数の定量ポンプによるガスの吸入若しく
は排出を同時に行いながら、前記自動バルブによりガス
を前記貯液部に導入するか、或は前記貯液部外に排出す
るかの制御と、ガスを前記貯液部から吸入するか、或は
前記貯液部外から吸入するかを制御することによって、
前記貯液部への試液の吸入と貯液部からの試液の分注を
独立して制御し得るようにしたことを特徴とする液体分
注装置。1. The method according to claim 1, wherein the gas pressure of the metering pump causes the sample solution to be sucked into and stored in the reservoir connected to the metering pump.
In a liquid dispensing apparatus for discharging a liquid, a plurality of sets of liquid dispensing units constituting one set including the metering pump and the liquid storage unit are provided, and an automatic valve is provided between the metering pump and the liquid storage unit. And controlling whether the automatic valve introduces gas into the liquid storage unit or discharges the gas out of the liquid storage unit while simultaneously performing suction or discharge of gas by the plurality of metering pumps. By controlling whether to inhale gas from the liquid storage part or from outside the liquid storage part,
A liquid dispensing apparatus characterized in that suction of a test solution into the storage portion and dispensing of the test solution from the storage portion can be controlled independently.
ン棒を上下動させることにより構成し、前記複数の定量By moving the rod up and down,
ポンプのピストン棒を同時に上下動させる請求項１記載The piston rod of the pump is simultaneously moved up and down.
の分注装置。Dispensing device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18864293A JP3339650B2 (en) | 1993-07-02 | 1993-07-02 | Liquid dispensing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18864293A JP3339650B2 (en) | 1993-07-02 | 1993-07-02 | Liquid dispensing device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0720010A JPH0720010A (en) | 1995-01-24 |
| JP3339650B2 true JP3339650B2 (en) | 2002-10-28 |
Family
ID=16227291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18864293A Expired - Fee Related JP3339650B2 (en) | 1993-07-02 | 1993-07-02 | Liquid dispensing device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3339650B2 (en) |
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| EP2697657B8 (en) | 2011-04-15 | 2017-08-16 | Becton, Dickinson and Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
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-
1993
- 1993-07-02 JP JP18864293A patent/JP3339650B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0720010A (en) | 1995-01-24 |
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