JP3161739B2 - Medical container - Google Patents
Medical containerInfo
- Publication number
- JP3161739B2 JP3161739B2 JP41740690A JP41740690A JP3161739B2 JP 3161739 B2 JP3161739 B2 JP 3161739B2 JP 41740690 A JP41740690 A JP 41740690A JP 41740690 A JP41740690 A JP 41740690A JP 3161739 B2 JP3161739 B2 JP 3161739B2
- Authority
- JP
- Japan
- Prior art keywords
- container
- partition
- medical container
- welding
- inner layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Description
【０００１】[0001]
【産業上の利用分野】本発明は、偏平なプラスチック製
医療用容器に関する。さらに詳しくは、アミノ酸輸液剤
とブドウ糖輸液剤のように、栄養学的見地から混合投与
が望ましいが、混合すると経時的にメーラード反応等が
進行する輸液剤、或いはある種の抗生物質製剤のように
製剤学的安定性の理由から、投与直前に液剤に溶かして
用いられるものなどに使用するための、隔離収容及び無
菌的混合が可能な多室からなる容器に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a flat plastic medical container. More specifically, as in amino acid infusion and glucose infusion, mixed administration is desirable from a nutritional point of view, but when mixed, infusions such as Maillard reaction that progresses over time, or in certain antibiotics TECHNICAL FIELD The present invention relates to a multi-chamber container capable of being isolated and housed and aseptically mixed for use in, for example, being dissolved in a liquid immediately before administration for reasons of pharmaceutical stability.
【０００２】[0002]
【従来の技術】前述したような多室容器は、従来より種
々提案されている。例えば、偏平な可撓性容器を隔壁で
仕切って分室を形成するとともに、分室間に封止・解除
可能な手段を設けたもの（特開昭57−52455 、特開昭61
−90729 、特開昭63−11161)、あるいはプラスチック製
多層シートで作られた容器の内層を帯状に接着して分室
を形成し、その接着部を剥離可能としたもの、すなわち
仕切部剥離方式容器（特開昭63−19149 、特開平1-2404
69、特開平2-4671）等が開示されている。2. Description of the Related Art Various types of multi-chamber containers have been proposed. For example, a flat flexible container is partitioned by partition walls to form compartments, and means for sealing and releasing are provided between the compartments (Japanese Patent Application Laid-Open Nos. Sho 57-52455 and Sho 61
-90729, JP-A-63-11161) or an inner layer of a container made of a plastic multi-layer sheet is adhered in a strip shape to form a compartment, and the adhesive portion can be peeled off, that is, a partition-peeling type container (JP-A-63-19149, JP-A-1-2404)
69, JP-A-2-4671) and the like.
【０００３】[0003]
【発明が解決しようとする課題】偏平なプラスチック製
容器の製造方法として、一般に、二枚のシートを重ねて
周縁を溶着する方法（シート方式）、インフレーション
成形チューブの両端開放部を溶着する方法（インフレ方
式）及びパリソンの一部を金型で挟み、気体を吹き込む
ことによって成形する方法（ブロー成形方式）の三通り
がある。その中でブロー成形方式は、液剤収納容器の輸
注口や吊り下げ部を、容器胴部の成形と同時に一体成形
できることから、シート方式やインフレ方式と比べ部品
数が少なくて済み、製造工程上有利である。そこで本発
明者らは、容器本体の製造方法としてブロー成形方式
を、また分室の隔離及び開通手段として、収容物の混合
が容易にできる仕切部剥離方式を採用することにした。As a method of manufacturing a flat plastic container, generally, a method in which two sheets are overlapped and the periphery is welded (sheet method), and a method in which both ends of an inflation molded tube are welded at both ends ( There are three methods: an inflation method) and a method (blow molding method) in which a part of a parison is sandwiched between molds and molded by blowing gas. Among them, the blow molding method has the advantage that the number of parts can be reduced compared to the sheet method and the inflation method because the infusion port and the hanging part of the liquid medicine container can be integrally molded at the same time as the molding of the container body. It is. Therefore, the present inventors have adopted a blow molding method as a method of manufacturing the container body, and a partition peeling method capable of facilitating mixing of the contents as a means for separating and opening the compartments.
【０００４】しかしながら、多層パリソンの上部（輸注
口形成部）と底部（吊り下げ部等形成部）を金型で挟
み、ブロー成形した後、容器胴部を帯状に熱溶着して仕
切部を形成し、輸注口及び吊り下げ部周辺の薄い板状不
要部を切除した医療用容器は、次の問題点があることが
判明した。すなわち、前記医療用容器に輸液剤を収容
し、***試験をした結果、容器に想定上限付近の外力が
加わると、輸注口や吊り下げ部周縁でピンホールが生じ
易く、液漏れの危険性があることが判った。なお、仕切
部の溶着は、仕切部を折り目にして容器を畳むことによ
り、十分保護できることが確認された。However, the upper portion (transport opening forming portion) and the bottom portion (hanging portion forming portion) of the multilayer parison are sandwiched by a mold and blow-molded, and then the container body is heat-welded in a belt shape to form a partition portion. However, it has been found that the medical container from which the thin plate-shaped unnecessary portion around the infusion port and the hanging portion has been cut has the following problems. That is, as a result of storing an infusion solution in the medical container and performing an abuse test, if an external force near the assumed upper limit is applied to the container, a pinhole is likely to occur at the periphery of the infusion port or the hanging portion, and there is a danger of liquid leakage. I found it to be. In addition, it was confirmed that the welding of the partition part can be sufficiently protected by folding the container with the partition part folded.
【０００５】したがって本発明の課題は、上記問題点を
解決することにより、製造工程及び部品数が少なくて済
む容器であって、異種輸液剤等の隔離収容と無菌的混合
が確実かつ容易にできる医療用容器を提供することにあ
る。SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to solve the above-mentioned problems by providing a container which requires only a small number of manufacturing steps and a small number of parts. It is to provide a medical container.
【０００６】[0006]
【課題を解決するための手段】本発明者らは、上記ピン
ホールの問題が、仕切部に適度な剥離容易性を持たせる
ため、パリソンの内層として溶着強度が相対的に小さい
素材を用いたこと、さらに輸注口や吊り下げ部周縁（不
要部切除部）において、パリソンを三角状の突起部を有
する金型で強く挟んだにもかかわらず、内層溶着面が僅
かながら露出していることに起因することを突き止め、
本発明を完成することができた。SUMMARY OF THE INVENTION The present inventors have used a material having relatively low welding strength as an inner layer of a parison in order to make the partition part have an appropriate peeling easiness. In addition, even though the parison was strongly sandwiched between the injection port and the periphery of the hanging part (removal part of the unnecessary part) with a mold having a triangular projection, the inner layer welding surface was slightly exposed. Ascertain the cause,
The present invention has been completed.
【０００７】請求項１記載の医療用容器は、プラスチッ
ク製ブロー成形による偏平容器の対向する内壁面が前記
偏平容器の両側一端から他端にかけて帯状に溶着されて
なる仕切部により複数の分室が形成された医療用容器で
あって、前記仕切部を形成する溶着部位ないし近傍のフ
ィルムが多層構造であり、その内層の素材が外層及び他
部位の素材と異なることを特徴とする。また、請求項２
記載の医療用容器は、プラスチック製ブロー成形による
偏平容器の対向する内壁面が帯状に溶着されてなる仕切
部により複数の分室が形成された医療用容器であって、
前記仕切部を形成する溶着部位ないし近傍のフィルムが
多層構造であり、その内層の素材又は外層の素材のいず
れか一方が複数の素材の混合物であることを特徴とす
る。[0007] In the medical container according to the first aspect, a plurality of compartments are formed by a partition portion in which opposing inner wall surfaces of the flat container made of plastic blow molding are welded in a band shape from one end to the other end on both sides of the flat container. Wherein the welded portion forming the partition or the film in the vicinity thereof has a multilayer structure, and the material of the inner layer is different from the material of the outer layer and other portions. Claim 2
The medical container described is a medical container in which a plurality of compartments are formed by a partition portion in which opposing inner wall surfaces of a flat container made of plastic blow molding are welded in a band shape,
It is characterized in that the film at or near the welded portion forming the partition has a multilayer structure, and one of the material of the inner layer and the material of the outer layer is a mixture of a plurality of materials.
【０００８】本発明容器の素材は、生体に有害な物質が
溶出しない熱可塑性のプラスチックを用いる。例えば、
ポリエチレン、ポリプロピレン、ポリ塩化ビニル、エチ
レン酢酸ビニル共重合体、あるいはそれらの混合物等が
好適に使用できる。前記の如く部分的な内層の素材とし
ては、融点が相対的に高く熱溶着性が比較的弱いもの又
は引張強度が相対的に小さいものが好ましい。一方、外
層及び他部位の素材としては、熱溶着性が良好で引張強
度が相対的に大きいものが好ましい。内層の素材：外層
及び他部位の素材の好適な組合せとして、例えば、ポリ
プロピレン：ポリエチレン、ポリプロピレンとポリエチ
レンの混合物：ポリエチレンなどを挙げることができ
る。The material of the container of the present invention is a thermoplastic plastic from which no harmful substances to the living body are eluted. For example,
Polyethylene, polypropylene, polyvinyl chloride, ethylene-vinyl acetate copolymer, or a mixture thereof can be suitably used. As described above, the material of the partial inner layer is preferably a material having a relatively high melting point and a relatively low heat welding property or a material having a relatively low tensile strength. On the other hand, as the material of the outer layer and other parts, those having good heat welding properties and relatively high tensile strength are preferable. Suitable combinations of the material of the inner layer: the material of the outer layer and the material of the other portion include, for example, polypropylene: polyethylene, and a mixture of polypropylene and polyethylene: polyethylene.
【０００９】前記内層の範囲は、必ずしも溶着部位ない
しその近傍のみに限定されず、パリソン不要部切除部位
近傍を除く全域であってもよい。また、外層及び他部位
は、製造上単層が好ましいが２層以上の多層構造であっ
てもよい。The range of the inner layer is not necessarily limited to the welded portion or the vicinity thereof, but may be the entire region excluding the vicinity of the parison unnecessary portion excision portion. In addition, the outer layer and other parts are preferably a single layer in production, but may have a multilayer structure of two or more layers.
【００１０】[0010]
【作用】偏平なプラスチック製ブロー成形容器におい
て、溶着部位ないし近傍の内層に、外層及び他部位と異
なった素材を使用することにより、それぞれの部位に適
した特性を持つ素材の選択ができ、適度な剥離容易性を
持つ仕切部と、液漏れの生じる心配のない容器周縁（特
に切り口が露出する輸注口及び吊り下げ部周縁）の形成
が可能となった。[Function] In a flat plastic blow-molded container, by using a material different from the outer layer and other parts for the welding part or the inner layer in the vicinity, it is possible to select a material having characteristics suitable for each part. It has become possible to form a partition part having excellent peeling easiness and a container periphery (particularly, an infusion opening and a hanging part periphery where the cut end is exposed) without fear of liquid leakage.
【００１１】[0011]
【実施例】一実施例として、部分内層の素材にポリエチ
レンとポリプロピレンの混合物を、外層及び他部位の素
材にポリエチレンをそれぞれ使用し、パリソン共押出装
置で中間部を部分２層とした中空パリソンをブロー成形
した。次いで２層部位、すなわち容器中間部位の両側一
端から他端にかけ約５mm幅で加圧下、熱溶着して仕切部
（２）を形成した。EXAMPLE As one example, a mixture of polyethylene and polypropylene was used for the material of the partial inner layer, and polyethylene was used for the material of the outer layer and other parts, respectively. Blow molded. Next, a partition portion (2) was formed by heat welding under pressure with a width of about 5 mm from one end to the other end of both sides of the two-layer part, that is, the intermediate part of the container.
【００１２】仕切部の溶着強度は、輸液剤等を分室に収
容して確実に隔離保存ができ、しかも容器を手で圧迫す
るなどして剥離できる適度の強さが必要である。したが
って、好ましい熱溶着の条件は、フィルムの材質と厚
さ、さらには溶着幅等に依存し、通常、15〜30Kg重／cm
2 、120〜180 ℃、5〜15秒間である。[0012] The welding strength of the partition portion needs to have an appropriate strength so that an infusion solution or the like can be contained in a compartment and reliably isolated and stored, and that the container can be peeled off by pressing the container by hand. Therefore, preferable conditions for heat welding depend on the material and thickness of the film, furthermore, the welding width, etc., and are usually 15 to 30 kgf / cm.
2 , 120-180 ° C for 5-15 seconds.
【００１３】図１は、上記の如く製造した容器の肩部か
ら輸注口（５）周辺、及び底部から吊り下げ部（６）周
辺〔この例では両側に充填口（７）を具備する〕に形成
された薄い板状不要部を切除した本発明医療用容器
（１）の正面図である。FIG. 1 shows the container manufactured as described above from the shoulder to the vicinity of the infusion port (5), and from the bottom to the vicinity of the hanging part (6) (in this example, filling ports (7) are provided on both sides). It is a front view of the medical container (1) of the present invention from which the formed thin plate-like unnecessary part was cut off.
【００１４】図２は、本発明における一実施例の断面図
であって、仕切部（２）付近の内層（３）と外層及び他
部位（４）の関係を示す説明図である。FIG. 2 is a cross-sectional view of one embodiment of the present invention, and is an explanatory view showing the relationship between the inner layer (3), the outer layer, and other parts (4) near the partition (2).
【００１５】[0015]
【発明の効果】本発明によれば、製造工程と部品数が少
なくて済む容器であって、使用に際しては、混合保存が
できない輸液剤等を安全かつ確実に隔離収容でき、投与
前に容易に無菌的混合ができる医療用容器が提供でき
る。According to the present invention, a container which requires a small number of manufacturing steps and a small number of parts can be used to safely and reliably isolate and contain an infusion solution or the like which cannot be mixed and stored, and can be easily prepared before administration. A medical container capable of aseptic mixing can be provided.
【図１】本発明における一実施例の正面図。FIG. 1 is a front view of one embodiment of the present invention.
【図２】本発明における一実施例の断面図。FIG. 2 is a sectional view of one embodiment of the present invention.
１ 本発明の医療用容器 ２ 仕切部 ３ 内層 ４ 外層及び他部位 ５ 輸注口 ６ 吊り下げ部 ７ 充填口 DESCRIPTION OF SYMBOLS 1 Medical container of this invention 2 Partition part 3 Inner layer 4 Outer layer and other parts 5 Infusion port 6 Hanging part 7 Filling port
Claims (2)
器の対向する内壁面が前記偏平容器の両側一端から他端
にかけて帯状に溶着されてなる仕切部により複数の分室
が形成された医療用容器であって、前記仕切部を形成す
る溶着部位ないし近傍のフィルムが多層構造であり、そ
の内層の素材が外層及び他部位の素材と異なることを特
徴とする医療用容器。1. A medical container in which a plurality of compartments are formed by a partition formed by welding opposite inner wall surfaces of a flat container made of plastic blow molding from one end to the other end on both sides of the flat container. A medical container characterized in that a film at or near a welding portion forming the partition has a multilayer structure, and a material of an inner layer thereof is different from a material of an outer layer and other portions.
器の対向する内壁面が帯状に溶着されてなる仕切部によ
り複数の分室が形成された医療用容器であって、前記仕
切部を形成する溶着部位ないし近傍のフィルムが多層構
造であり、その内層の素材又は外層の素材のいずれか一
方が複数の素材の混合物であることを特徴とする医療用
容器。2. A medical container in which a plurality of compartments are formed by a partition formed by welding opposing inner wall surfaces of a flat container made of plastic blow molding in a belt shape, wherein a welding portion forming the partition is provided. A medical container characterized in that the film in the vicinity has a multilayer structure, and one of the material of the inner layer and the material of the outer layer is a mixture of a plurality of materials.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP41740690A JP3161739B2 (en) | 1990-12-28 | 1990-12-28 | Medical container |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP41740690A JP3161739B2 (en) | 1990-12-28 | 1990-12-28 | Medical container |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04242647A JPH04242647A (en) | 1992-08-31 |
| JP3161739B2 true JP3161739B2 (en) | 2001-04-25 |
Family
ID=18525514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP41740690A Expired - Fee Related JP3161739B2 (en) | 1990-12-28 | 1990-12-28 | Medical container |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3161739B2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW294632B (en) * | 1993-02-05 | 1997-01-01 | Otsuka Pharma Factory Inc | |
| JPH07299117A (en) * | 1994-05-09 | 1995-11-14 | Showa Denko Kk | Infusion bag |
| JP2734413B2 (en) * | 1995-07-04 | 1998-03-30 | 株式会社ニッショー | Infant beverage container |
| EP1394071B1 (en) | 2001-06-07 | 2012-12-26 | Mitsubishi Chemical Corporation | Duplex container |
-
1990
- 1990-12-28 JP JP41740690A patent/JP3161739B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04242647A (en) | 1992-08-31 |
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