JP3091213B2 - Reagent evaporation prevention method - Google Patents

Reagent evaporation prevention method

Info

Publication number
JP3091213B2
JP3091213B2 JP02286978A JP28697890A JP3091213B2 JP 3091213 B2 JP3091213 B2 JP 3091213B2 JP 02286978 A JP02286978 A JP 02286978A JP 28697890 A JP28697890 A JP 28697890A JP 3091213 B2 JP3091213 B2 JP 3091213B2
Authority
JP
Japan
Prior art keywords
reagent
liquid
reagent container
container
probe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP02286978A
Other languages
Japanese (ja)
Other versions
JPH04161855A (en
Inventor
昌夫 牛久保
康雄 森
幹夫 渡辺
博之 町田
睦朗 加柴
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olympus Corp
Original Assignee
Olympus Optic Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Olympus Optic Co Ltd filed Critical Olympus Optic Co Ltd
Priority to JP02286978A priority Critical patent/JP3091213B2/en
Publication of JPH04161855A publication Critical patent/JPH04161855A/en
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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002Reagent dispensers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/16Preventing evaporation or oxidation of non-metallic liquids by applying a floating layer, e.g. of microballoons
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178Special arrangements of analysers
    • G01N2035/00277Special precautions to avoid contamination (e.g. enclosures, glove- boxes, sealed sample carriers, disposal of contaminated material)
    • G01N2035/00287Special precautions to avoid contamination (e.g. enclosures, glove- boxes, sealed sample carriers, disposal of contaminated material) movable lid/cover for sample or reaction tubes

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Description

【発明の詳細な説明】 [産業上の利用分野] 本発明は、容器内に収容された試薬の蒸発防止方法に
関するものである。
Description: TECHNICAL FIELD The present invention relates to a method for preventing evaporation of a reagent contained in a container.

[従来の技術] 複数種の試薬を用いて被検試料を自動分析する装置と
して、複数の試薬容器をケース内に設けられたターンテ
ーブル上に載置し、ターンテーブルを回転させて試薬容
器をケース外に設けられたプローブの下方に位置させ、
プローブを降下させて容器内の試薬を吸引するようにし
た自動分析装置が従来より知られている。
[Related Art] As an apparatus for automatically analyzing a test sample using a plurality of types of reagents, a plurality of reagent containers are placed on a turntable provided in a case, and the turntable is rotated to remove the reagent containers. Positioned below the probe provided outside the case,
2. Description of the Related Art An automatic analyzer in which a probe is lowered to suck a reagent in a container has been conventionally known.

この種の自動分析装置はターンテーブル上に置かれた
試薬容器が開封されているため、試薬の質的劣化等を防
止するために容器内の試薬を5〜10℃の温度範囲で保存
する必要がある。しかし、容器内の試薬を5〜10℃の低
温度で保存すると、ケース内の空気が低湿度となるた
め、容器内の試薬が蒸発し、その濃度が変化してしまう
などの問題がある。
In this type of automatic analyzer, the reagent container placed on the turntable is opened, so it is necessary to store the reagent in the container at a temperature range of 5 to 10 ° C to prevent qualitative deterioration of the reagent. There is. However, when the reagent in the container is stored at a low temperature of 5 to 10 ° C., the air in the case becomes low in humidity, so that there is a problem that the reagent in the container evaporates and its concentration changes.

そこで、この問題を解決するために第5図に示すよう
な自動分析装置が実公平1−24628号で提案されてい
る。第5図において、1は試薬容器を収納するための収
容ケースであり、この収納ケース1の上面にはプローブ
2,3をケース1内へ挿入するための挿入口4,5が形成され
ている。また、収納ケース1内には円形状のターンテー
ブル6が設けられている。このターンテーブル6はその
中心部をモータ8と連結した回転軸7に保持されてお
り、モータ8により駆動されるようになっている。
In order to solve this problem, an automatic analyzer as shown in FIG. 5 has been proposed in Japanese Utility Model Publication No. 1-262828. In FIG. 5, reference numeral 1 denotes a storage case for storing a reagent container, and a probe is provided on the upper surface of the storage case 1.
Insertion holes 4, 5 for inserting the 2, 3 into the case 1 are formed. A circular turntable 6 is provided in the storage case 1. The turntable 6 is held by a rotating shaft 7 whose center is connected to a motor 8, and is driven by the motor 8.

上記ターンテーブル6の上面には、試薬を収容した複
数の試薬容器9がターンテーブル6の周方向に一定間隔
で、かつターンテーブル6の半径方向に2個ずつ配置さ
れている。これらの試薬容器9はターンテーブル6上に
設けられた保持板10に保持されており、保持板10の上面
には試薬容器9の開口部を開閉する開閉機構11がターン
テーブル6の周方向に配置された試薬容器9の数だけ設
けられている。
On the upper surface of the turntable 6, a plurality of reagent containers 9 containing reagents are arranged at regular intervals in the circumferential direction of the turntable 6 and two in a radial direction of the turntable 6. These reagent containers 9 are held by a holding plate 10 provided on the turntable 6, and an opening / closing mechanism 11 for opening and closing the opening of the reagent container 9 is provided on the upper surface of the holding plate 10 in the circumferential direction of the turntable 6. As many reagent containers 9 as are provided are provided.

上記開閉機構11は第6図に示す如く構成されており、
保持板10の上面にはアングル部材12a,12bがターンテー
ブル6の半径方向に配置された2個の試薬容器9を挟む
ように固定されている。これらのアングル部材12a,12b
間には、ほぼコの字形をなす可動支持部材13が支持軸14
を介して回動自在に支持されている。この可動支持部材
13の下面中央にはリベット等の連結部材15が突設されて
おり、連結部材15には保持部材16が上下方向に揺動自在
に保持されている。この保持部材16の両端部にはゴムま
たはスポンジ等の弾性材からなる蓋板17が取付けてお
り、これらの蓋17で試薬容器9の開口部を密閉するよう
になっている。なお、可動支持部材13はつる巻ばねによ
り所定方向に回動偏倚されており、蓋板17はつる巻ばね
のばね力によって試薬容器9の開口部に押し付けられて
いる。
The opening / closing mechanism 11 is configured as shown in FIG.
Angle members 12 a and 12 b are fixed to the upper surface of the holding plate 10 so as to sandwich two reagent containers 9 arranged in the radial direction of the turntable 6. These angle members 12a, 12b
A movable support member 13 having a substantially U-shape is provided between the support shaft 14
And is rotatably supported via the. This movable support member
A connecting member 15 such as a rivet is protrudingly provided at the center of the lower surface of 13, and a holding member 16 is held by the connecting member 15 so as to be vertically swingable. A lid plate 17 made of an elastic material such as rubber or sponge is attached to both ends of the holding member 16, and the lid 17 seals the opening of the reagent container 9. The movable support member 13 is rotationally biased in a predetermined direction by a helical spring, and the cover plate 17 is pressed against the opening of the reagent container 9 by the spring force of the helical spring.

また、上記支持軸14の一端部には受け部18aを有する
レバー18が取付けられている。このレバー18の受け部18
aには第5図に示す如くリンクロッド19の下端が当接し
ており、このリンクロッド19でレバー18を押し下げるこ
とにより可動支持部材13がつる巻ばねのばね力に抗して
支持軸14を中心に回動するようになっている。そして、
可動支持部材13が支持軸14を中心に回動すると、保持部
材16の両端部に保持された蓋板17が試薬容器9の開口部
上から移動し、これにより試薬容器9の開口部が開放さ
れるようになっている。なお、リンクロッド19は軸21を
支点として回動するレバー20の一端に連結しており、上
記レバー20の回動によって上下方向に移動するようにな
っている。
A lever 18 having a receiving portion 18a is attached to one end of the support shaft 14. Receiving part 18 of this lever 18
As shown in FIG. 5, the lower end of a link rod 19 is in contact with a. When the lever 18 is pushed down by this link rod 19, the movable support member 13 causes the support shaft 14 to resist the spring force of the helical spring. It is designed to rotate around the center. And
When the movable support member 13 rotates about the support shaft 14, the lid plates 17 held at both ends of the holding member 16 move from above the opening of the reagent container 9, thereby opening the opening of the reagent container 9. It is supposed to be. Note that the link rod 19 is connected to one end of a lever 20 that rotates about a shaft 21, and moves up and down by the rotation of the lever 20.

上記のような構成において、試薬容器9内に収容され
た試薬をプローブ2,3で吸引する場合は、まずモータ8
によりターンテーブル6を回転させ、吸引しようとする
試薬が収容された試薬容器9を挿入口4,5の真下に位置
させる。次に開口機構11を駆動して挿入口4,5の真下に
位置する試薬容器9の開口部を開放した後、プローブ2,
3を降下させ、挿入口4,5より収納ケース1内に挿入され
たプローブ2,3の先端部を試薬容器9内に挿入し、試薬
容器9内の試薬Aをプローブ2,3で吸引する。
In the above configuration, when the reagents contained in the reagent container 9 are sucked by the probes 2 and 3, the motor 8
Then, the turntable 6 is rotated to position the reagent container 9 containing the reagent to be aspirated just below the insertion ports 4 and 5. Next, the opening mechanism 11 is driven to open the opening of the reagent container 9 located immediately below the insertion ports 4 and 5, and then the probes 2 and
3 is lowered, the tips of the probes 2, 3 inserted into the storage case 1 from the insertion ports 4, 5 are inserted into the reagent container 9, and the reagent A in the reagent container 9 is sucked by the probes 2, 3. .

ところで、このような自動分析装置では、試薬容器9
内に収容された試薬の蒸発を開閉機構11によって防止す
ることはできるが、収納ケース1内に複数の開閉機構11
を設けなければならない。このため、構成が複雑になる
と共に収納ケース1が大型化してしまうという問題があ
った。
By the way, in such an automatic analyzer, the reagent container 9
Although the evaporation of the reagent contained in the storage case 1 can be prevented by the opening and closing mechanism 11, the plurality of opening and closing mechanisms 11
Must be provided. Therefore, there is a problem that the configuration becomes complicated and the size of the storage case 1 becomes large.

[発明が解決しようとする課題] 本発明は上記のような問題点に鑑みてなされたもの
で、その目的は試薬容器内に収容された試薬の蒸発を機
械的な機構を用いることなく防止することのできる試薬
の蒸発防止方法を提供することにある。
[Problems to be Solved by the Invention] The present invention has been made in view of the above problems, and an object of the present invention is to prevent evaporation of a reagent contained in a reagent container without using a mechanical mechanism. It is an object of the present invention to provide a method for preventing evaporation of a reagent.

[課題を解決するための手段] 上記課題を解決するために本発明は、保冷状態に置か
れた試薬容器中に繰り返し分取用プローブを侵入させて
試薬容器から液状試薬を分取して複数の分析を行う際に
適用され、前記試薬容器の上部開口を分取用のプローブ
が繰り返し侵入できるように充分開口させたままの状態
とするとともに、少なくとも複数の分析を行う間、前記
液状試薬よりも比重が軽く、前記液状試薬と混合せず、
且つ保冷時の低温下でも蒸発しない非蒸発性液体を前記
試薬容器中の前記液状試薬の上面全体に覆うように収容
させ、前記分取用プローブは分取する 毎に前記非蒸発性液体を通過して前記液状試薬中に侵入
してから吸引を行うように設定してなることを特徴とす
るものである。
[Means for Solving the Problems] In order to solve the above problems, the present invention provides a method in which a dispensing probe is repeatedly penetrated into a reagent container placed in a cool state, and a liquid reagent is dispensed from the reagent container. It is applied when performing the analysis, while keeping the upper opening of the reagent container sufficiently open so that the preparative probe can repeatedly enter, while performing at least a plurality of analyzes, Also has a low specific gravity, does not mix with the liquid reagent,
In addition, a non-evaporable liquid that does not evaporate even at a low temperature during cold storage is accommodated so as to cover the entire upper surface of the liquid reagent in the reagent container, and the dispensing probe passes the non-evaporable liquid every time dispensing is performed. Then, suction is performed after entering into the liquid reagent.

[作 用] 上記の方法によると、試薬容器に収容された試薬の液
面が液体によって覆われ、空気との接触が防止されるの
で、機械的な機構を用いることなく試薬の蒸発を防止す
ることができる。
[Operation] According to the above method, the liquid surface of the reagent contained in the reagent container is covered with the liquid and the contact with the air is prevented, so that the evaporation of the reagent is prevented without using a mechanical mechanism. be able to.

[実施例] 以下、本発明の一実施例を図面を参照して説明する。Hereinafter, an embodiment of the present invention will be described with reference to the drawings.

第2図は、本発明方法を適用した自動分析装置の収納
ケース内を示す断面図である。同図において、1は収納
ケース、2,3はプローブ、4,5は挿入口、6はターンテー
ブル、7は回転軸、8はモータであり、これらは第5図
に示したものと同一のものである。また、9はターンテ
ーブル6上に設置された試薬容器であり、この試薬容器
9内には第1図に示す如く試薬Aと、この試薬Aより比
重が軽くかつ試薬Aと混合しない液体(例えばシリコー
ン油、流動パラフィン、フルオロカーボン等)Bが収容
されている。なお、この実施例の場合には液体Bは低湿
度でも蒸発しない液体である。
FIG. 2 is a sectional view showing the inside of a storage case of the automatic analyzer to which the method of the present invention is applied. In the figure, 1 is a storage case, 2 and 3 are probes, 4 and 5 are insertion ports, 6 is a turntable, 7 is a rotating shaft, and 8 is a motor, which are the same as those shown in FIG. Things. Reference numeral 9 denotes a reagent container provided on the turntable 6. The reagent container 9 contains a reagent A and a liquid having a specific gravity lower than that of the reagent A and not mixed with the reagent A (for example, as shown in FIG. 1). B) is contained therein. In this embodiment, the liquid B is a liquid that does not evaporate even at low humidity.

上記の構成において、試薬容器9内に収容された試薬
Aをプローブ2,3で吸引する場合は、まずモータ8によ
りターンテーブル6を回転させ、吸引しようとする試薬
が収容された試薬容器9を挿入口4,5の真下に位置させ
る。次にプローブ2,3を降下させ、挿入口4,5より収納ケ
ース1内に挿入されたプローブ2,3の先端部を試薬容器
9内の試薬A中に浸漬し、試薬Aをプローブ2,3で吸引
する。そして、試薬容器9内の試薬Aをプローブ2,3で
吸引した後は、プローブ2,3を試薬容器9内から引き上
げる。このとき、試薬Aの液面は第3図及び第4図に示
す如く試薬Aより比重が軽くかつ試薬Aと混合しない液
体Bによって覆われているので、空気との接触が防止さ
れ、機械的な機構を用いることなく試薬Aの蒸発を防止
することができる。従って、上記実施例では収納ケース
1内に試薬容器9の開口部を開閉する開閉機構を設置す
る必要がないので、構成の簡略化を図ることができると
共に収納ケース1内に多数の試薬容器9を収納すること
ができる。
In the above configuration, when aspirating the reagent A contained in the reagent container 9 with the probes 2 and 3, the turntable 6 is first rotated by the motor 8 to remove the reagent container 9 containing the reagent to be aspirated. It is located just below the insertion holes 4 and 5. Next, the probes 2 and 3 are lowered, and the tips of the probes 2 and 3 inserted into the storage case 1 from the insertion ports 4 and 5 are immersed in the reagent A in the reagent container 9, and the reagent A is Aspirate with 3. Then, after aspirating the reagent A in the reagent container 9 with the probes 2 and 3, the probes 2 and 3 are pulled up from the reagent container 9. At this time, the liquid surface of the reagent A is covered with the liquid B having a lower specific gravity than the reagent A and not mixed with the reagent A as shown in FIG. 3 and FIG. Evaporation of the reagent A can be prevented without using a simple mechanism. Therefore, in the above embodiment, there is no need to provide an opening / closing mechanism for opening and closing the opening of the reagent container 9 in the storage case 1, so that the configuration can be simplified and a large number of reagent containers 9 can be stored in the storage case 1. Can be stored.

なお、上記実施例では本発明方法を自動分析装置に適
用した場合について説明したが、本発明はこれに限定さ
れるものではなく、自動分析装置以外の装置についても
適用可能である。
In the above embodiment, the case where the method of the present invention is applied to an automatic analyzer has been described. However, the present invention is not limited to this, and can be applied to devices other than the automatic analyzer.

[発明の効果] 以上説明したように本発明は、液状試薬を収容した試
薬容器内に試薬より比重が軽く、試薬と混合せず、且つ
保冷時の低温下でも蒸発しない非蒸発性の液体によって
液状試薬の上面全体を覆うようにしたので、保冷中の蒸
発を有効に防止することできる。しかも、試薬容器の上
部開口を分取用のプローブが繰り返し侵入できるように
充分開口させたままの状態とするとともに分取用プロー
ブによる吸引はプローブが非蒸発性液体を通過して液状
試薬中に侵入してから行うようにしたことにより、複数
の分析を行う間、いつでも自由に試薬の分取が可能であ
るとともに、複数回の分取に応じて試薬容器内の液状試
薬が次第に少量へと容量が変化したとしても非蒸発性液
体による蒸発防止作用は安定に維持されるため、いつま
でも液状試薬が濃縮されることがなく、分析性能が変化
する虞れも無い。従って、試薬容器内に収容された液状
試薬の液面が非蒸発性液体によって覆われ、繰り返し液
状試薬が分取される間、常に空気との接触が完全に防止
され続けるので、複数の分析を行う場合に機械的な機構
を用いることなく保冷条件下の試薬における蒸発を有効
に防止することができる試薬の蒸発防止方法を提供でき
る。
[Effects of the Invention] As described above, the present invention uses a non-evaporable liquid in a reagent container containing a liquid reagent, which has a lower specific gravity than the reagent, does not mix with the reagent, and does not evaporate even at a low temperature during cooling. Since the entire upper surface of the liquid reagent is covered, evaporation during cooling can be effectively prevented. In addition, the upper opening of the reagent container is kept sufficiently open so that the preparative probe can repeatedly enter, and suction by the preparative probe allows the probe to pass through the non-evaporable liquid and into the liquid reagent. By performing the analysis after the invasion, the reagent can be freely collected at any time during multiple analyzes, and the liquid reagent in the reagent container gradually decreases to a small amount in response to the multiple samples. Even if the volume changes, the evaporation preventing action of the non-evaporable liquid is stably maintained, so that the liquid reagent is not concentrated forever, and there is no possibility that the analytical performance changes. Therefore, the liquid surface of the liquid reagent contained in the reagent container is covered with the non-evaporable liquid, and while the liquid reagent is repeatedly dispensed, contact with the air is always completely prevented, so that a plurality of analyzes can be performed. It is possible to provide a method for preventing evaporation of a reagent, which can effectively prevent evaporation of a reagent under cold-holding conditions without using a mechanical mechanism when performing the method.

【図面の簡単な説明】[Brief description of the drawings]

第1図〜第4図は本発明方法を説明するための図で、第
1図は試薬容器の縦断面図、第2図は本発明方法を適用
した自動分析装置の試薬容器収納ケース内を示す断面
図、第3図及び第4図は同実施例の作用を説明するため
の説明図、第5図及び第6図は従来技術を説明するため
の図である。 1……収納ケース、2,3……プローブ、4,5……挿入口、
6……ターンテーブル、7……回転軸、8……モータ、
9……試薬容器、A……試薬、B……液体。
1 to 4 are views for explaining the method of the present invention. FIG. 1 is a longitudinal sectional view of a reagent container, and FIG. 2 is a view showing the inside of a reagent container storage case of an automatic analyzer to which the method of the present invention is applied. FIGS. 3 and 4 are explanatory views for explaining the operation of the embodiment, and FIGS. 5 and 6 are views for explaining the prior art. 1 ... Storage case, 2,3 ... Probe, 4,5 ...
6 ... turntable, 7 ... rotating shaft, 8 ... motor,
9: reagent container, A: reagent, B: liquid.

───────────────────────────────────────────────────── フロントページの続き (72)発明者 渡辺 幹夫 東京都渋谷区幡ケ谷2丁目43番2号 オ リンパス光学工業株式会社内 (72)発明者 町田 博之 東京都渋谷区幡ケ谷2丁目43番2号 オ リンパス光学工業株式会社内 (72)発明者 加柴 睦朗 東京都渋谷区幡ケ谷2丁目43番2号 オ リンパス光学工業株式会社内 (56)参考文献 特開 昭64−49963(JP,A) 特開 昭51−16442(JP,A) 特開 昭55−57272(JP,A) 特開 平1−292134(JP,A) 特開 平2−34683(JP,A) 実開 平4−30039(JP,U) 実開 平1−136262(JP,U) 実公 平1−24628(JP,Y2) ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Mikio Watanabe 2-43-2 Hatagaya, Shibuya-ku, Tokyo O-limpus Optical Industry Co., Ltd. (72) Inventor Hiroyuki Machida 2-43-2 Hatagaya, Shibuya-ku, Tokyo Inside Olympus Optical Co., Ltd. (72) Inventor Mutsuro Kashiba 2-43-2 Hatagaya, Shibuya-ku, Tokyo Inside Olympus Optical Co., Ltd. (56) References JP-A-64-49963 (JP, A) JP-A-51-16442 (JP, A) JP-A-55-57272 (JP, A) JP-A-1-292134 (JP, A) JP-A-2-34683 (JP, A) JP-A-4-30039 (JP, U) Japanese Utility Model Hei 1-136262 (JP, U) Japanese Utility Model Hei 1-24628 (JP, Y2)

Claims (1)

(57)【特許請求の範囲】(57) [Claims] 【請求項1】保冷状態に置かれた試薬容器中に繰り返し
分取用プローブを侵入させて試薬容器から液状試薬を分
取して複数の分析を行う際に適用され、 前記試薬容器の上部開口を分取用のプローブが繰り返し
侵入できるように充分開口させたままの状態とするとと
もに、少なくとも複数の分析を行う間、前記液状試薬よ
りも比重が軽く、前記液状試薬と混合せず、且つ保冷時
の低温下でも蒸発しない非蒸発性液体を前記試薬容器中
の前記液状試薬の上面全体に覆うように収容させ、前記
分取用プローブは分取する毎に前記非蒸発性液体を通過
して前記液状試薬中に侵入してから吸引を行うように設
定してなることを特徴とする試薬の蒸発防止方法。
1. An upper opening of the reagent container, which is applied when a plurality of analysis is performed by separating a liquid reagent from the reagent container by repeatedly injecting a preparative probe into the reagent container placed in a cool state. Is kept sufficiently open so that the preparative probe can repeatedly enter, and while performing at least a plurality of analyses, the specific gravity is lower than the liquid reagent, not mixed with the liquid reagent, and kept cool. A non-evaporable liquid that does not evaporate even at a low temperature is accommodated so as to cover the entire upper surface of the liquid reagent in the reagent container, and the dispensing probe passes the non-evaporable liquid every time dispensing is performed. A method for preventing evaporation of a reagent, wherein suction is performed after entering the liquid reagent.
JP02286978A 1990-10-26 1990-10-26 Reagent evaporation prevention method Expired - Fee Related JP3091213B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP02286978A JP3091213B2 (en) 1990-10-26 1990-10-26 Reagent evaporation prevention method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP02286978A JP3091213B2 (en) 1990-10-26 1990-10-26 Reagent evaporation prevention method

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP22856799A Division JP3253937B2 (en) 1999-08-12 1999-08-12 Reagent storage device

Publications (2)

Publication Number Publication Date
JPH04161855A JPH04161855A (en) 1992-06-05
JP3091213B2 true JP3091213B2 (en) 2000-09-25

Family

ID=17711431

Family Applications (1)

Application Number Title Priority Date Filing Date
JP02286978A Expired - Fee Related JP3091213B2 (en) 1990-10-26 1990-10-26 Reagent evaporation prevention method

Country Status (1)

Country Link
JP (1) JP3091213B2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10185927A (en) * 1996-12-20 1998-07-14 Dai Ichi Pure Chem Co Ltd Method for stabilizing liquid reagent and reagent unit
JP4092018B2 (en) * 1998-09-14 2008-05-28 第一化学薬品株式会社 Aqueous reagents and air blocking agents for aqueous samples

Also Published As

Publication number Publication date
JPH04161855A (en) 1992-06-05

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