JP3046110B2 - Fiber-chitosan composite porous body, absorbent pad using the same, and chemical liquid impregnated pad - Google Patents
Fiber-chitosan composite porous body, absorbent pad using the same, and chemical liquid impregnated padInfo
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- JP3046110B2 JP3046110B2 JP28671891A JP28671891A JP3046110B2 JP 3046110 B2 JP3046110 B2 JP 3046110B2 JP 28671891 A JP28671891 A JP 28671891A JP 28671891 A JP28671891 A JP 28671891A JP 3046110 B2 JP3046110 B2 JP 3046110B2
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- fiber
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Description
【０００１】[0001]
【産業上の利用分野】本発明はキトサン及び水溶性食物
繊維を主原料とした複合多孔質体、それを用いた吸収性
パッド及び薬液含浸パッドに関する。本複合多孔質体は
優れた吸収性、保水性を有する抗菌性多孔質構造体とし
て、医療用、公衆衛生用、化粧用の各種パッドとして広
く用い得るものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composite porous material mainly composed of chitosan and water-soluble dietary fiber, and to an absorbent pad and a chemical impregnated pad using the same. The composite porous body is an antibacterial porous structure having excellent absorption and water retention properties, and can be widely used as various pads for medical use, public health, and cosmetics.
【０００２】[0002]
【従来の技術】キトサンは、カニ、エビ等の甲殻類、カ
ブトムシ等の昆虫に含まれるキチンを脱アセチル化して
誘導される高分子物質である。キチンは生物界ではセル
ロースに次いで多量に生産されており、これから誘発さ
れるキトサンはキチン同様、種種の分野への応用が期待
されている物質である。キトサンと食物繊維との組み合
わせでは、紙基材にキトサンを処理して食肉製品を充填
するケーシング用材料としての利用（特開平１−１７４
６９９号）、天然パルプシートにキトサンを塗布した農
業用シート（特開平２−２３０３号）等が知られてい
る。2. Description of the Related Art Chitosan is a high molecular substance derived by deacetylating chitin contained in crustaceans such as crabs and shrimps and insects such as beetles. Chitin is produced in the living world in the second largest amount after cellulose, and chitosan derived therefrom, like chitin, is expected to be applied to various fields. In the combination of chitosan and dietary fiber, it is used as a casing material for filling a meat product by treating a paper base with chitosan (Japanese Unexamined Patent Publication No. 1-174).
No. 699), an agricultural sheet obtained by applying chitosan to a natural pulp sheet (Japanese Patent Application Laid-Open No. 2-2303), and the like.
【０００３】一方、食物繊維は近年になって、難消化性
成分として大きな関心を集め、第６の栄養素とも呼ば
れ、一躍脚光を浴びるようになっている。ところで、食
物繊維には大別して水溶性と水不溶性のものがあるが、
水溶性食物繊維と不溶性食物繊維とではそれぞれ物理化
学的特性が異なることも分かってきている。特に、水溶
性食物繊維は、イオン交換能、保水能、膨潤能、ゲル形
成能、高粘性を有するものが多く、物理化学特性を利用
した増粘剤・安定剤や食物繊維の生理効果を期待した食
品として広く用いられている。しかしながら、従来、キ
トサンの組み合わせで用いられてきた食物繊維は専ら水
不溶性繊維であり、その主要目的は強度の向上であっ
た。水溶性食物繊維を構造体として形成し保水能、膨潤
能等の特性を有効に利用した例は知られておらず、ま
た、水溶性食物繊維をそのまま溶解して使用したのでは
保形性がないため利用不可能である。[0003] On the other hand, dietary fiber has recently attracted great interest as an indigestible component, and is also called the sixth nutrient, and has come to the spotlight. By the way, dietary fiber is roughly classified into water-soluble and water-insoluble,
It has also been found that water-soluble dietary fiber and insoluble dietary fiber have different physicochemical properties. In particular, many water-soluble dietary fibers have ion exchange ability, water retention ability, swelling ability, gel-forming ability, and high viscosity. Expect the physiological effects of thickeners / stabilizers and dietary fiber utilizing physicochemical properties. It is widely used as food. However, dietary fiber conventionally used in combination with chitosan is exclusively water-insoluble fiber, and its main purpose was to improve strength. There is no known example of using water-soluble dietary fiber as a structure to effectively utilize properties such as water-retaining ability and swelling ability. Not available because it is not available.
【０００４】[0004]
【発明が解決しようとする課題】本発明は、上記従来技
術の実情に鑑み、キトサンを利用し水溶性食物繊維の構
造体を図り、吸収性部材として優れた機能を発揮する食
物繊維素材を提供することを目的とする。SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned circumstances of the prior art, and provides a dietary fiber material which exhibits excellent functions as an absorbent member by using chitosan to form a water-soluble dietary fiber structure. The purpose is to do.
【０００５】[0005]
【課題を解決するための手段】かかる目的は、次に示す
手段により達成される。すなわち、本発明は、水溶性食
物繊維とキトサンを一体化して多孔質化してなる組織を
有する複合多孔質体のアセチル化処理物である、耐水性
の繊維−キトサン複合多孔質体であり、また、該複合多
孔質体を用いた吸収性パッド及び薬液含浸パッドであ
る。本発明の繊維−キトサン複合多孔質体は、耐水性及
び保水性に極めて優れており、保水性を有する構造体と
して医療、衛生、化粧等の各分野において広く利用でき
る。This object is achieved by the following means. That is, the present invention is a water-resistant fiber-chitosan composite porous body, which is an acetylated product of a composite porous body having a structure obtained by integrating water-soluble dietary fiber and chitosan into a porous body, And an absorbent pad and a chemical liquid impregnated pad using the composite porous body. The fiber-chitosan composite porous material of the present invention is extremely excellent in water resistance and water retention, and can be widely used as a structure having water retention in various fields such as medical treatment, hygiene, and cosmetics.
【０００６】本発明において、複合体とは、キトサンが
水溶性食物繊維に化学的又は物理的に結合もしくは付着
した構造をいうが、この構造をアセチル化すると、キト
サンと水溶性食物繊維が固定化された安定複合体ができ
る。水溶性食物繊維は、キトサンに固定化されているた
め水を充分に含んで膨らむにもかかわらず保形性を保
ち、しかも水溶性食物繊維が流出することはない。In the present invention, a complex refers to a structure in which chitosan is chemically or physically bonded or attached to water-soluble dietary fiber. When this structure is acetylated, chitosan and water-soluble dietary fiber are immobilized. A stable complex is obtained. Since the water-soluble dietary fiber is immobilized on chitosan, the water-soluble dietary fiber sufficiently retains shape despite being swollen with sufficient water, and the water-soluble dietary fiber does not flow out.
【０００７】以下、本発明を詳述する。本発明において
対象となる水溶性食物繊維とは、多糖類を主体とした水
溶性の難消化性成分をいい、その由来問わず、植物由来
多糖類、海藻由来多糖類、微生物由来多糖類、及び化学
修飾多糖類等があげられる。植物由来多糖類としては、
グアガム、ローカストビーンガム、タラガム、ペクチ
ン、マンナン、ヘミセルロース、β−グルカン等の穀物
ガム質が例示され、海藻由来多糖類としては、アルギン
酸、カラギーナン、ファーセレラン等があり、微生物由
来多糖類として、キサンタンガム、プルラン等があげら
れるし、化学修飾多糖類としては、ポリデキストロー
ス、カルボキシルメチルセルロース等がある。なお、上
述の水溶性食物繊維は１種又は２種以上の混合物として
用いることができる。Hereinafter, the present invention will be described in detail. The water-soluble dietary fiber targeted in the present invention refers to a water-soluble indigestible component mainly composed of polysaccharide, regardless of its origin, plant-derived polysaccharide, seaweed-derived polysaccharide, microorganism-derived polysaccharide, and Chemically modified polysaccharides and the like can be mentioned. As plant-derived polysaccharides,
Guar gum, locust bean gum, tara gum, pectin, mannan, hemicellulose, cereal gums such as β-glucan, and the like, as seaweed-derived polysaccharides, there are alginic acid, carrageenan, furceleran, etc., as microorganism-derived polysaccharides, xanthan gum, Pullulan and the like; and chemically modified polysaccharides include polydextrose and carboxymethyl cellulose. The above-mentioned water-soluble dietary fiber can be used alone or as a mixture of two or more.
【０００８】次に、本発明において用い得るキトサンは
キチンの脱アセチル化物であり、製法は問わずに用いる
ことができる。キトサンの重合度及び脱アセチル化度
は、キトサンの溶解性、安定性等に影響を及ぼし、重合
度の低いものほど、溶解しやすく定着しやすいが、構造
体の強度が低下する傾向があり、また、脱アセチル化度
の低いものほど、反応性が乏しく溶解しにくい傾向があ
る。水溶性食物繊維と一体化し耐水生保形性を発揮させ
るためには、ある程度の構造性を有するキトサンが好ま
しく、上市されているものでは一般に高粘性キトサンと
称されているものがよい。Next, chitosan that can be used in the present invention is a deacetylated product of chitin, and can be used regardless of the production method. The degree of polymerization and the degree of deacetylation of chitosan affect the solubility and stability of chitosan, and the lower the degree of polymerization, the easier it is to dissolve and fix, but the strength of the structure tends to decrease, Also, the lower the degree of deacetylation, the lower the reactivity and the more difficult it is to dissolve. In order to integrate with the water-soluble dietary fiber and exhibit water-resistant life-preserving property, chitosan having a certain degree of structural property is preferable, and those on the market that are generally called high-viscosity chitosan are preferable.
【０００９】次に、本発明の繊維−キトサン複合多孔質
体（以下、複合多孔質体という。）はその組織を形成す
るに際してまず水溶性食物繊維とキトサンを湿式混合に
より一体化する。ここに、湿式混合とは、水溶性食物繊
維とキトサンの両者を水溶液に溶解した状態で混合する
ことをいう。湿式混合により、はじめて水溶性食物繊維
はｐＨ４．８以下、好ましくはｐＨ４以下の酸性下でい
ずれも溶解するので、５０倍〜１００倍量程度の希酸溶
液に溶解・混合することができる。また、一体化とは、
均質に混合しポリイオンコンプレックスを形成すること
をいうが、ポリイオンコンプレックスの形成程度、態様
は特に限定されず、目的とする複合多孔質体により適宜
調整すればよい。すなわち、最終的な複合多孔質体が、
キトサンが水溶性食物繊維に結合もしくは付着した構造
を有するように調製する。Next, the fiber-chitosan composite porous body of the present invention (hereinafter, referred to as composite porous body) is formed by integrating water-soluble dietary fiber and chitosan by wet mixing when forming the tissue. Here, the wet mixing means that both water-soluble dietary fiber and chitosan are mixed in a state of being dissolved in an aqueous solution. Only by wet mixing, the water-soluble dietary fiber dissolves under acidic conditions of pH 4.8 or less, preferably pH 4 or less, and can be dissolved and mixed in a dilute acid solution of about 50 to 100 times. Also, integration is
This means that the polyion complex is formed by homogeneous mixing, but the degree and mode of formation of the polyion complex are not particularly limited, and may be appropriately adjusted depending on the intended composite porous body. That is, the final composite porous body is
It is prepared so that chitosan has a structure bound or attached to the water-soluble dietary fiber.
【００１０】次に、本発明の複合多孔質体の特徴は、上
述の構造に加え多孔質であることである。多孔質体であ
るため、軽量でかつ、充分な強度を有するにもかかわら
ず優れた吸収性を得ることが可能となり、さらに、所望
の力学的特性を付与する幅が広くなる。多孔質としての
嵩比重は０．０８〜０．４ｇ／ｃｃ程度が通常である
が、目的とする複合多孔質体の用途等により適宜設定す
ればよい。孔径は特に限定されるものでなく、目的とす
る力学的特性との関係で設計すればよい。通常１０〜５
００μｍ程度でよい。嵩比重が小さく、孔径が大きけれ
ば複合多孔質体は吸水性、弾力に富むが、強度、耐水性
が低下し、一方、嵩比重が大きく、孔径が小さければ、
硬くなり吸水性が低減し、強度及び耐水性が増大する。Next, the feature of the composite porous body of the present invention is that it is porous in addition to the above-mentioned structure. Since it is a porous body, it is possible to obtain excellent absorbency despite being lightweight and having sufficient strength, and furthermore, the range of imparting desired mechanical properties is widened. The bulk specific gravity of the porous material is usually about 0.08 to 0.4 g / cc, but may be appropriately set depending on the intended use of the composite porous body. The hole diameter is not particularly limited, and may be designed in relation to the desired mechanical characteristics. Usually 10-5
It may be about 00 μm. If the bulk specific gravity is small and the pore size is large, the composite porous body is rich in water absorption and elasticity, but the strength and water resistance are reduced, while if the bulk specific gravity is large and the pore size is small,
Hardens, reduces water absorption and increases strength and water resistance.
【００１１】ところで、この構造体は水溶性食物繊維を
含有しているため優れた保水性、ゲル化性、膨潤性を発
揮するが、該繊維は基本的に水溶性であり、また、キト
サンも希酸可溶性であるため、構造上、水の影響を受け
る。水可溶性の構造体を目的とすれば、特別な処理は不
要であるが、耐水性構造体とする場合は、不溶化処理が
必要である。すなわち、得られた複合多孔質体は優れた
保水性を有するが、これを水に浸漬すると、構造を形成
しているキトサン及び繊維が膨潤し水に溶解してくるの
で、複合多孔質体は保形性を失う。By the way, since this structure contains water-soluble dietary fiber, it exhibits excellent water retention, gelling and swelling properties. However, the fiber is basically water-soluble, and chitosan is Because it is soluble in dilute acid, it is affected by water in its structure. No special treatment is required for a water-soluble structure, but in the case of a water-resistant structure, an insolubilization treatment is required. That is, the obtained composite porous body has excellent water retention, but when immersed in water, the chitosan and fibers forming the structure swell and dissolve in water, so the composite porous body is Loses shape retention.
【００１２】したがって、比較的長時間使用するもので
は、どろどろになってくる場合がある。ところがこの複
合多孔質体をアセチル化処理により不溶化すると、水溶
性食物繊維と一体化しているキトサンがアセチル化する
ことで、該繊維の有する機能をほとんど損なうことなく
組織を維持し安定化させることができる。その理由はま
ず、アセチル化前にすでに、複合多孔質体が組織上分子
レベルで一体化しており、キトサン分子が、水溶性食物
繊維の分子とポリイオンコンプレックス等によりからみ
合い、水溶性食物繊維の分子を物理的又は化学的、電気
的に拘束していると考えられ、例えば、水溶性食物繊維
分子の親水性基であるカルボキシル基はキトサンのアミ
ノ基との間で結合を行い、親水性を低下させるとともに
架橋構造を形成する。この状態で、さらにキトサンがア
セチル化することで、構造は大幅に、分子レベルで安定
化し繊維の吸水性等の機能を維持したまま構造上の強度
及び耐水性を実現できると考えられる。[0012] Therefore, if the device is used for a relatively long time, it may become lumpy. However, when the composite porous body is insolubilized by acetylation treatment, chitosan integrated with the water-soluble dietary fiber is acetylated, so that the tissue can be maintained and stabilized without substantially impairing the function of the fiber. it can. First, before the acetylation, the composite porous body is already integrated at the molecular level on the tissue, and the chitosan molecules are entangled with the molecules of the water-soluble dietary fiber by a polyion complex, etc., and the molecules of the water-soluble dietary fiber Is considered to be physically or chemically constrained electrically, for example, a carboxyl group, which is a hydrophilic group of a water-soluble dietary fiber molecule, binds with an amino group of chitosan to reduce hydrophilicity. And a crosslinked structure is formed. In this state, further acetylation of chitosan is considered to significantly stabilize the structure at the molecular level and realize structural strength and water resistance while maintaining functions such as water absorption of the fiber.
【００１３】通常、脱アセチル化度６０％以上のキトサ
ンを原料として用いても酢酸溶液等を用いる関係で最終
製品のアセチル化度は４０％〜５０％程度となってい
る。この程度のアセチル化度では、耐水性は期待できな
いので、アセチル化処理を施し、アセチル化度を６０〜
７０％又はそれ以上とすれば耐水化できる。Usually, even when chitosan having a degree of deacetylation of 60% or more is used as a raw material, the degree of acetylation of the final product is about 40% to 50% due to the use of an acetic acid solution or the like. With this degree of acetylation, water resistance cannot be expected, so acetylation treatment is performed to increase the acetylation degree to 60 to
If it is 70% or more, water resistance can be achieved.
【００１４】水不溶性の機能を発揮させるためにはキト
サンと水溶性食物繊維の重量比は重要な要件である。す
なわち、キトサンと水溶性食物繊維との重量比は好まし
くは１：０．５〜１：５であり、この範囲内である場合
は、キトサンの結合もしくは付着性が有効に発揮され、
保形性を保つことができる。水溶性食物繊維の比率が多
すぎると固定化が充分でなく水溶性食物繊維が溶出して
しまう。また、水溶性食物繊維の比率が少なすぎる場合
は、水溶性食物繊維の物性を利用した保湿剤の目的に合
わない。In order to exert the water-insoluble function, the weight ratio of chitosan to water-soluble dietary fiber is an important requirement. That is, the weight ratio of chitosan to water-soluble dietary fiber is preferably 1: 0.5 to 1: 5, and within this range, the binding or adhesion of chitosan is effectively exhibited,
Shape retention can be maintained. If the ratio of the water-soluble dietary fiber is too large, the immobilization is not sufficient and the water-soluble dietary fiber elutes. On the other hand, if the ratio of the water-soluble dietary fiber is too small, the purpose of the humectant utilizing the physical properties of the water-soluble dietary fiber is not met.
【００１５】次に、本発明の複合多孔質体の調製法の一
例について述べる。まず、水、キトサン、水溶性食物繊
維及び酢酸よりなる混合溶液を調製する。酢酸以外でも
乳酸、クエン酸、塩酸等も用い得る。キトサンと水溶性
食物繊維はｐＨ４．８以下、好ましくはｐＨ４以下の酸
性下でいずれも溶解するので、５０倍〜１００倍量の水
に溶解・混合することが可能である。混合液は中和後、
使用形態に応じて任意の形・厚さの型に入れて多孔質化
させ、次いでアセチル化すると、キトサンに水溶性食物
繊維が固定化されたキトサン複合体ができる。水溶性食
物繊維は、キトサンに固定化されているため水を充分に
含んで膨らむにもかかわらず保形性を保ち、しかも水溶
性食物繊維が流出することはない。Next, an example of a method for preparing the composite porous body of the present invention will be described. First, a mixed solution composed of water, chitosan, water-soluble dietary fiber and acetic acid is prepared. In addition to acetic acid, lactic acid, citric acid, hydrochloric acid and the like may be used. Since both chitosan and water-soluble dietary fiber dissolve under acidic conditions of pH 4.8 or less, preferably pH 4 or less, they can be dissolved and mixed in 50 to 100 times the amount of water. After the mixture is neutralized,
Depending on the form of use, it is placed in a mold of any shape and thickness to make it porous, and then acetylated to form a chitosan complex in which water-soluble dietary fibers are immobilized on chitosan. Since the water-soluble dietary fiber is immobilized on chitosan, it retains its shape-retaining property despite being sufficiently swollen with sufficient water, and does not leak out of the water-soluble dietary fiber.
【００１６】多孔質化させる方法としては、炭酸水素ナ
トリウムや炭酸水素アンモニウム等熱分解型の発泡剤や
さらに酸性剤を加えたベーキングパウダー等の反応型の
発泡剤を混合する方法、あるいはミキサー等で機械的に
空気を混入させる方法等、一般に用いられている方法で
よい。微細な孔を形成させるには、溶液の凍結乾燥が最
も好ましく、この場合は吸水性及び保水性の双方を維持
したまま多孔質化と乾燥を同時にできる利点もある。As a method for making the porous material, a method of mixing a pyrolytic foaming agent such as sodium hydrogencarbonate or ammonium hydrogencarbonate or a reactive foaming agent such as baking powder to which an acidic agent is further added, or a mixer or the like. A generally used method such as a method of mechanically mixing air may be used. Lyophilization of the solution is most preferable for forming fine pores. In this case, there is also an advantage that porosity and drying can be simultaneously performed while maintaining both water absorption and water retention.
【００１７】アセチル化は、例えば無水酢酸のアルコー
ル溶液に浸漬又は、無水酢酸をガス状にした雰囲気中に
さらすことで実施できる。特にガス状無水酢酸を用いる
方法は、その後の中和水洗工程が不要であり、かつ、ア
セチル化度のコントロールも容易であるところから、秀
れた方法である。アセチル化度が高くなれば溶解性が低
くなり安定性が増す。通常は、ガス中では１時間で約６
８％がアセチル化できる。なお、その後一晩処理を続け
ても７０％ぐらいで横バイとなる。構造体の乾燥は通常
１００〜１５０℃、３〜１２時間程度で実施できる。Acetylation can be carried out, for example, by immersion in an alcoholic solution of acetic anhydride or exposure to an atmosphere in which acetic anhydride is gasified. In particular, the method using gaseous acetic anhydride is an excellent method because a subsequent neutralizing and washing step is unnecessary and the control of the degree of acetylation is easy. The higher the degree of acetylation, the lower the solubility and the higher the stability. Normally, about 6 hours per hour in gas
8% can be acetylated. It should be noted that, even if the processing is continued overnight, a horizontal buyout occurs at about 70%. Drying of the structure can usually be carried out at 100 to 150 ° C. for about 3 to 12 hours.
【００１８】本発明の複合多孔質体は保水性を維持した
状態での吸水性として、荷重の逆数と保水量との回帰式
から無限大荷重時の保水量を外挿して求めた値を用いて
表わせば、１５００〜３０００ｍｇ／ｇ（乾物）程度の
保水量を保持できる。すなわち、単に水を高度に吸収す
るだけではなく、加重をかけても離水量が小さく構造を
維持することができる。この機能は医療、化粧、衛生等
の分野における用途を想定した場合、極めて大きなメリ
ットとなる。さらに、本複合多孔質体はキトサンを含有
しているため抗菌性も発揮され、上記の分野での用途を
より有益なものとすることができる。また、乾燥状態で
もある程度の弾力があり、また形状の制限がないため用
途にほとんど制限がない。The composite porous body of the present invention uses, as the water absorption while maintaining the water retention, a value obtained by extrapolating the water retention at an infinite load from the regression equation of the reciprocal of the load and the water retention. If expressed, the water retention amount of about 1500 to 3000 mg / g (dry matter) can be maintained. That is, the structure can be maintained not only by simply absorbing water to a high degree, but also by a small amount of water separation even when a load is applied. This function is a great advantage when it is assumed to be used in the fields of medicine, cosmetics, hygiene and the like. Furthermore, since the present composite porous material contains chitosan, it also exhibits antibacterial properties, and can be more useful in the above fields. In addition, there is a certain degree of elasticity even in a dry state, and there is no restriction on the shape, so there is almost no restriction on the application.
【００１９】具体的な用途としては、まず、吸収性パッ
ドが挙げられる。吸収性パッドとは外部からの液体を吸
収する目的で用いられるパッドであるが、例えば止血用
パッド、傷当てパッド、生理用パッド等に好適である。
実際に用いる場合は、本複合多孔質体を適当な支持部材
等に固定し、適宜、目的に合った形態とすればよい。As a specific application, first, an absorbent pad is cited. The absorbent pad is a pad used for the purpose of absorbing a liquid from the outside, and is suitable for, for example, a hemostatic pad, a wound pad, a sanitary pad, and the like.
When actually used, the composite porous body may be fixed to an appropriate support member or the like, and may be formed in a form suitable for the purpose.
【００２０】また、本複合多孔質体に薬液を含浸させ薬
液含浸パッドとすることもできる。含浸された薬液は荷
重が付加されても外部へしみ出しにくいため薬液を有効
に創傷患部等に接触させることができる。含浸できる薬
液は、複合多孔質体の組織を侵食しないものであれば、
いずれも適用できる。本複合多孔質体は生体適合体が高
く皮膚との親和性がよく患部治癒を助長することができ
る。適当な支持部材を組み合わせれば創傷被覆保護材等
とできる。Further, the composite porous body may be impregnated with a chemical solution to form a chemical solution impregnated pad. The impregnated drug solution is unlikely to exude to the outside even when a load is applied, so that the drug solution can be effectively brought into contact with an affected wound or the like. Chemicals that can be impregnated are those that do not erode the tissue of the composite porous body,
Either can be applied. The composite porous body has a high biocompatibility and has good affinity with the skin, and can promote healing of the affected part. A wound covering protective material or the like can be obtained by combining an appropriate supporting member.
【００２１】[0021]
【実施例】以下実施例に基づき本発明を具体的に説明す
る。The present invention will be specifically described below with reference to examples.
【００２２】実施例１ 水溶性食物繊維は高メトキシルペクチン（ブラウンＮ
Ｆ、サノファイバイオインダストリーズ）を、キトサン
は高粘性キトサン（ＣＡＴ−２、カタクラチッカリン）
を用いた。ペクチン５ｇとキトサン５ｇを５００ｍｌの
水に混合し、酢酸５ｇを添加して酸性（ｐＨ３）にして
両者を溶解させた。溶解液は、パットにシート状に敷い
て凍結乾燥した後、５％の無水酢酸のエチルアルコール
溶液に１０分間浸漬してアセチル化した。次いで１％水
酸化ナトリウム溶液に浸漬して中和した後、試料をよく
水洗して通風乾燥（１０５℃、２時間）してシート状の
複合多孔質体を得た。このもののアセチル化度は７０％
で、吸水させると軟らかいスポンジゲル状になった。こ
のものの保水力については後述の試験例に示す。Example 1 The water-soluble dietary fiber was high methoxyl pectin (Brown N
F, Sanofi Bio-Industries), and chitosan is highly viscous chitosan (CAT-2, catacraticalin)
Was used. 5 g of pectin and 5 g of chitosan were mixed in 500 ml of water, and 5 g of acetic acid was added to make it acidic (pH 3) to dissolve both. The lysate was spread on a pad in a sheet form, freeze-dried, and then immersed in a 5% acetic anhydride in ethyl alcohol solution for 10 minutes for acetylation. Next, the sample was neutralized by immersion in a 1% sodium hydroxide solution, and the sample was thoroughly washed with water and air-dried (105 ° C., 2 hours) to obtain a sheet-like composite porous body. This product has a degree of acetylation of 70%
Then, it became a soft sponge gel when water was absorbed. The water retention capacity of this is shown in the test examples described later.
【００２３】実施例２ 水溶性食物繊維は米ヌカヘミセルロース（ボーソー油脂
（株）製）を、キトサンは高粘性キトサン（キミツキト
サンＭＰ、キミツ化学）を用いた。米ヌカヘミセルロー
ス５０ｇとキトサン５０ｇを５リットルの水に混合し、
クエン酸５０ｇを添加して酸性（ｐＨ２．９）にして両
者を溶解させた。溶解液は凍結乾燥後、５％の無水酢酸
のエチルアルコール溶液に１０分間浸漬してアセチル化
した。次いで、１％水酸化ナトリウム溶液に浸漬して中
和した後水洗を行い、通風乾燥して薄いシート状の複合
多孔質体を得た。このものはアセチル化度６８％で、水
を加えればよく膨潤した。このものの保水力については
次の試験例に示す。Example 2 As the water-soluble dietary fiber, rice bran hemicellulose (manufactured by Boso Inc.) was used, and as the chitosan, high-viscosity chitosan (Kimitsukitosan MP, Kimitsu Chemical) was used. 50 g of rice bran hemicellulose and 50 g of chitosan are mixed in 5 liters of water,
Both were dissolved by adding 50 g of citric acid to make it acidic (pH 2.9). After lyophilization, the lysate was acetylated by immersion in a 5% acetic anhydride in ethyl alcohol solution for 10 minutes. Next, the sheet was neutralized by immersion in a 1% sodium hydroxide solution, washed with water, and dried by ventilation to obtain a thin sheet-like composite porous body. It had a degree of acetylation of 68% and swelled well when water was added. The water retention capacity of this is shown in the following test example.
【００２４】試験例 （方法）無限大荷重時の保水量の測定 充分に水を含んだ複合多孔質体に１ｋｇ，３．３６ｋ
ｇ，１０ｋｇの荷重をかけ、該多孔質体乾物１ｇあたり
に保持された水分（ｍｇ）を算出した。荷重の逆数と保
水量との回帰式から無限大荷重時の保水量を外挿して求
めた。上記の測定法に従い実施例１及び２で得られた複
合多孔質体の無限大荷重時の保水量を測定した。比較の
ため、不溶性食物繊維であるパルプをキトサンに固定化
したものを対照として同様に試験した。結果を図１及び
表１に示す。この図及び表からも明らかなように実施例
１及び２の複合多孔質体ではいずれの荷重においても保
水力が対照品よりも優れていた。Test Example (Method) Measurement of Water Retention Amount Under Infinite Load 1 kg, 3.36 k of a composite porous body containing sufficient water
g and a load of 10 kg were applied, and the water content (mg) per 1 g of the dry matter of the porous body was calculated. From the regression equation between the reciprocal of the load and the water retention, the water retention at infinite load was extrapolated and found. According to the above measurement method, the water retention of the composite porous bodies obtained in Examples 1 and 2 at an infinite load was measured. For comparison, an insoluble dietary fiber pulp immobilized on chitosan was similarly tested as a control. The results are shown in FIG. As is clear from this figure and the table, the composite porous bodies of Examples 1 and 2 were superior in water retention ability to the control product under any load.
【００２５】[0025]
【表１】 実施例３ 実施例１の複合体を２５ｍｍ×２０ｍｍ（乾燥時の厚さ
約２ｍｍ）に裁断し、リバノール液に浸し、充分に膨潤
した後、約１ｋｇの加重で圧搾して、遊離する薬剤を除
去した。１０ｍｍ×１０ｍｍ以下で深さ１ｍｍ以下の創
傷を受けた人にその都度、この複合体貼付剤あるいは従
来のガーゼに同様にリバノール液を浸漬・圧搾した貼付
剤をつけてもらった。ガーゼ貼付剤（比較品）をつけた
ボランティア５名は、薬剤が一部流出して衣服にシミが
付いたこと、回復はあまり早まらないことを挙げた。一
方、複合体貼付剤をつけたボランティア５名は、薬剤の
流出がないこと、傷口から出る血液を複合体がよく吸収
し、かさぶたができるのが早かったことを挙げた。[Table 1] Example 3 The composite of Example 1 was cut into 25 mm × 20 mm (thickness of about 2 mm when dried), immersed in rivanol solution, swelled sufficiently, and squeezed with a load of about 1 kg to release the released drug. Removed. Each time a person who had a wound of 10 mm × 10 mm or less and 1 mm or less in depth was asked to apply this composite patch or a patch obtained by immersing and pressing a rivanol solution in a conventional gauze in the same manner. Five volunteers wearing the gauze patch (comparative product) stated that some of the drug leaked and stained their clothes, and that recovery was not so fast. On the other hand, five volunteers wearing the complex patch stated that there was no outflow of the drug and that the complex absorbed blood coming out of the wound well and that the scab was formed quickly.
【００２６】[0026]
【発明の効果】以上説明したように、本発明の複合多孔
質体は優れた吸水性を有し、かつ保形性にも優れてお
り、荷重付加時の離水量が少ない。またキトサンの抗菌
性、生体適合性も発揮され医療、衛生、化粧等の各分野
で広汎に用い得る。特に、各種吸収性パッド、薬液含浸
パッドとして好適であり、高い有用性がある。As described above, the composite porous body of the present invention has excellent water absorption, excellent shape retention, and a small amount of water separation when a load is applied. In addition, the antibacterial properties and biocompatibility of chitosan are exhibited, and it can be widely used in various fields such as medical care, hygiene, and cosmetics. In particular, it is suitable as various absorbent pads and chemical liquid impregnated pads, and has high utility.
【図１】本発明の実施例で得られた複合多孔質体の保水
力を、荷重の逆数と保水量との回帰式で表わした図であ
る。FIG. 1 is a diagram showing the water retention capacity of a composite porous body obtained in an example of the present invention by a regression equation between a reciprocal of a load and a water retention amount.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ Ｃ０８Ｌ 5/08 Ｃ０８Ｌ 5/08 // Ｃ０８Ｌ 5:00 (58)調査した分野(Int.Cl.7，ＤＢ名) C08J 9/00 - 9/42 A61K 9/70 C08L 5/00 - 5/16 ──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. 7 identification code FI C08L 5/08 C08L 5/08 // C08L 5:00 (58) Field surveyed (Int.Cl. 7 , DB name) C08J 9 / 00-9/42 A61K 9/70 C08L 5/00-5/16
Claims (5)
多孔質化してなる組織を有する複合多孔質体のアセチル
化処理物である、繊維−キトサン複合多孔質体。1. A fiber-chitosan composite porous body, which is an acetylated product of a composite porous body having a structure obtained by integrating water-soluble dietary fiber and chitosan into a porous body.
藻由来多糖類、微生物由来多糖類、及び化学修飾多糖類
から選ばれた少なくとも１種である請求項１に記載の繊
維−キトサン複合多孔質体。2. The fiber-chitosan complex according to claim 1, wherein the water-soluble dietary fiber is at least one selected from a plant-derived polysaccharide, a seaweed-derived polysaccharide, a microorganism-derived polysaccharide, and a chemically modified polysaccharide. Porous body.
１：０．５〜１：５である請求項１に記載の繊維−キト
サン複合多孔質体。3. The fiber-chitosan composite porous material according to claim 1, wherein the weight ratio of chitosan to water-soluble dietary fiber is 1: 0.5 to 1: 5.
孔質体を用いた吸収性パッド。4. An absorbent pad using the fiber-chitosan composite porous material according to claim 1.
孔質体に薬液を含浸させてなる薬液含浸パッド。5. A chemical liquid impregnated pad obtained by impregnating a chemical liquid into the fiber-chitosan composite porous body according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28671891A JP3046110B2 (en) | 1991-10-31 | 1991-10-31 | Fiber-chitosan composite porous body, absorbent pad using the same, and chemical liquid impregnated pad |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28671891A JP3046110B2 (en) | 1991-10-31 | 1991-10-31 | Fiber-chitosan composite porous body, absorbent pad using the same, and chemical liquid impregnated pad |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05117431A JPH05117431A (en) | 1993-05-14 |
| JP3046110B2 true JP3046110B2 (en) | 2000-05-29 |
Family
ID=17708110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP28671891A Expired - Fee Related JP3046110B2 (en) | 1991-10-31 | 1991-10-31 | Fiber-chitosan composite porous body, absorbent pad using the same, and chemical liquid impregnated pad |
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| Country | Link |
|---|---|
| JP (1) | JP3046110B2 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19913478C1 (en) * | 1999-03-25 | 2000-07-20 | Hartmann Paul Ag | Breast pad insert for nursing mothers for purposes of milk absorption and prevention of garment staining contains chitosan |
| US6537584B1 (en) * | 1999-11-12 | 2003-03-25 | Macromed, Inc. | Polymer blends that swell in an acidic environment and deswell in a basic environment |
| CN110483832B (en) * | 2019-09-06 | 2022-03-04 | 云南师范大学 | Multi-characteristic natural rubber and agar composite mesoporous membrane and preparation method thereof |
-
1991
- 1991-10-31 JP JP28671891A patent/JP3046110B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05117431A (en) | 1993-05-14 |
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