JP2908923B2 - Biochemical automatic analyzer - Google Patents
Biochemical automatic analyzerInfo
- Publication number
- JP2908923B2 JP2908923B2 JP33515791A JP33515791A JP2908923B2 JP 2908923 B2 JP2908923 B2 JP 2908923B2 JP 33515791 A JP33515791 A JP 33515791A JP 33515791 A JP33515791 A JP 33515791A JP 2908923 B2 JP2908923 B2 JP 2908923B2
- Authority
- JP
- Japan
- Prior art keywords
- reaction detection
- reaction
- tubes
- detection tube
- detection tubes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- Automatic Analysis And Handling Materials Therefor (AREA)
Description
【０００１】[0001]
【産業上の利用分野】本発明は、サンプル及び試薬が分
注される複数本の反応検出管を回転移動させながら各反
応検出管の測光データを連続的に取得するとともに、反
応検出管を洗浄するようにした生化学自動分析装置に関
するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is to continuously obtain photometric data of each reaction detection tube while rotating a plurality of reaction detection tubes into which a sample and a reagent are dispensed, and to wash the reaction detection tubes. And a biochemical automatic analyzer.
【０００２】[0002]
【従来の技術】人体の血清等を対象として各種の化学分
析分析を行うための装置として自動化学分析装置が提案
されている。このような分析装置について、図５を参照
して説明する。図示しない回転テーブル上に設けられた
環状の反応検出管ホルダ１に複数本の反応検出管ａ〜ｏ
が保持され、例えば時計方向に回転駆動されて一定のサ
イクルで回転と停止が行われ、連続的に分析されるよう
になっている。反応検出管ホルダ１の周囲には、図示し
ないサンプル分注装置、第１試薬及び第２試薬分注装
置、洗浄装置等が配置され、それぞれ位置Ａでサンプル
分注、位置Ｂで第１試薬分注、位置Ｃで第２試薬分注、
位置Ｄで洗浄が行われる。１サイクル（１つの反応検出
管に試料を入れてから次の反応検出管に試料を入れるま
でのサイクル）において、反応検出管は（１回転＋１ピ
ッチ）分移動するようになっており、図５（ａ）の停止
状態を所定時間維持した後、ホルダ１は時計方向に所定
時間回転して（１回転＋１ピッチ）分移動し、図５
（ｂ）の状態で停止する。このようなサイクルを繰り返
し、洗浄位置Ｄにおいて、直前まで反応検出管に分注さ
れ混合されたサンプル及び試薬は洗い落とされ、（１回
転＋１ピッチ）分移動した位置Ａにおいて新たなサンプ
ルが分注され、さらに（１回転＋１ピッチ）分移動した
位置Ｂにおいて第１試薬が、位置Ｃにおいて第２試薬が
それぞれ分注され、ほぼ１回転する間に各反応検出管が
光源２と光検出器３を結ぶ光軸を横切り、このとき各反
応検出管の吸光度が検出される。以後、回転と停止を１
サイクルとして同様の動作を繰り返すことにより１ピッ
チごとに反応検出管が先に進み、連続的に各反応検出管
の測光が行われる。なお、１サイクルでの移動量は（１
回転−１ピッチ）とし、１サイクルごとに反応検出管が
後に進むようにしても同様である。2. Description of the Related Art An automatic chemical analyzer has been proposed as an apparatus for performing various chemical analysis analyzes on human serum or the like. Such an analyzer will be described with reference to FIG. A plurality of reaction detection tubes a to o are provided in an annular reaction detection tube holder 1 provided on a rotary table (not shown).
Is held, and is rotated and driven, for example, clockwise to rotate and stop in a fixed cycle, so that analysis is continuously performed. Around the reaction detection tube holder 1, a sample dispensing device (not shown), a first reagent and a second reagent dispensing device, a washing device, and the like are arranged. Note, dispensing the second reagent at position C,
The cleaning is performed at the position D. In one cycle (a cycle from the time when a sample is put into one reaction detection tube to the time when a sample is put into the next reaction detection tube), the reaction detection tube is moved by (one rotation + 1 pitch). After the stop state of (a) is maintained for a predetermined time, the holder 1 rotates clockwise for a predetermined time and moves by (one rotation + 1 pitch).
Stop in the state of (b). By repeating such a cycle, at the washing position D, the sample and the reagent dispensed and mixed into the reaction detection tube until immediately before are washed off, and a new sample is dispensed at the position A moved by (one rotation + 1 pitch). The first reagent is dispensed at a position B further moved by (one rotation + 1 pitch), and the second reagent is dispensed at a position C, and each reaction detection tube is connected to the light source 2 and the light detector 3 during substantially one rotation. Traverses the optical axis connecting, and at this time, the absorbance of each reaction detection tube is detected. After that, rotate and stop 1
By repeating the same operation as a cycle, the reaction detection tubes advance at every pitch, and photometry of each reaction detection tube is continuously performed. The movement amount in one cycle is (1
(Rotation-1 pitch), and the same applies to the case where the reaction detection tube advances after each cycle.
【０００３】[0003]
【発明が解決しようとする課題】ところで、上記従来の
分析装置において、分析に使用する反応検出管の総数を
Ｎ、１サイクルに検出をかねて移動する反応検出管の数
をＭとすると、一般に、 Ｎ±１＝Ｍ の関係がある。１サイクルの時間は回転時間と停止時間
の和となるが、装置における処理能力を上げるためには
１サイクルの時間を短縮する必要がある。しかし、停止
時間を縮めるのには限度があるので回転時間を縮めるこ
とが考えられるが、反応検出管の数が増加し、処理スピ
ードを速くしてほぼ１回転させながら反応検出管を測光
しようとすると、１反応検出管の測光に使用できる時間
が極めて短くなってしまい、信頼性のあるデータを取得
することができない。By the way, in the above-mentioned conventional analyzer, when the total number of reaction detection tubes used for analysis is N and the number of reaction detection tubes moving for one cycle for detection is M, generally, There is a relationship of N ± 1 = M. The time for one cycle is the sum of the rotation time and the stop time, but it is necessary to reduce the time for one cycle in order to increase the processing capacity of the apparatus. However, there is a limit to shorten the stop time, so it is conceivable to shorten the rotation time. However, the number of reaction detection tubes is increased. Then, the time available for photometry of one reaction detection tube becomes extremely short, and reliable data cannot be obtained.
【０００４】また、従来の装置では１サイクルで１ピッ
チずつ移動するために、試料分注の直近の位置で試薬分
注と反応検出管の洗浄を行うことになるため、試料分
注、試薬分注、反応検出管洗浄の位置関係が固定されて
しまい、装置構成上の自由度が無くなり、オペレーショ
ン上の最適配置が不可能になってしまうという問題があ
る。本発明は上記課題を解決するためのもので、各反応
検出管の測光時間を自由に設定でき、装置構成の自由度
を増して装置ユニットの最適配置を行うことができるよ
うにした生化学自動分析装置を提供することを目的とす
る。[0004] In addition, in the conventional apparatus, since one pitch is moved in each cycle, reagent dispensing and washing of the reaction detection tube are performed at a position near the sample dispensing. Note that there is a problem that the positional relationship of the reaction tube cleaning is fixed, the degree of freedom in the apparatus configuration is lost, and the optimal arrangement in operation becomes impossible. The present invention has been made to solve the above-mentioned problems, and it is possible to freely set the photometric time of each reaction detection tube, increase the degree of freedom of the device configuration, and perform the optimal arrangement of the device unit. An object of the present invention is to provide an analyzer.
【０００５】[0005]
【課題を解決するための手段】本発明は、少なくとも回
転テーブルに円周上に配置された複数の反応検出管、所
定位置で反応検出管にサンプルを分注するサンプル分注
装置、所定位置で反応検出管に試薬を分注する試薬分注
装置、反応の進行した反応検出管を洗浄する洗浄装置、
反応検出管の移動中に反応検出管を測光する検出器を備
え、１分析サイクルに複数本の反応検出管を移動させな
がら反応検出管を測光するようにした装置において、反
応検出管の数をＮ、１分析サイクルで移動する反応検出
管の数をＭとしたとき、Ｎ±１＝Ａ×Ｍ（Ａは２以上の
整数）、またはＮとＭの間に１以外の共通の因数が無
く、かつＭ＜Ｎ／２とし、反応検出管の移動を繰り返し
行って全ての反応検出管を順次使用して分析するように
したことを特徴とする。SUMMARY OF THE INVENTION The present invention is directed to a sample dispenser for dispensing a sample to a reaction detection tube at a predetermined position, a plurality of reaction detection tubes arranged at least on a circumference of a rotary table, A reagent dispensing device for dispensing a reagent to a reaction detection tube, a washing device for washing a reaction detection tube in which a reaction has progressed,
A device that has a detector for photometric reaction detection tubes while the reaction detection tubes are moving, and that measures the number of reaction detection tubes while moving a plurality of reaction detection tubes in one analysis cycle. N, where M is the number of reaction detection tubes moving in one analysis cycle, N ± 1 = A × M (A is an integer of 2 or more), or there is no common factor other than 1 between N and M And M <N / 2, and the reaction detection tubes are repeatedly moved to perform analysis using all the reaction detection tubes sequentially.
【０００６】[0006]
【作用】本発明は、円周上に配置された複数の反応検出
管を１分析サイクルに複数本分移動させ、サンプル分
注、試薬分注、反応検出管洗浄を行ないつつ、移動中に
反応検出管を測光する装置において、反応検出管の数を
Ｎ、１分析サイクルで移動する反応検出管の数をＭとし
たとき、Ｎ±１＝Ａ×Ｍ（Ａは２以上の整数）、あるい
はＮとＭの間に１以外の共通の因数が無く、かつＭ＜Ｎ
／２とすることにより、装置構成上の自由度を高めて、
装置ユニットの最適配置を容易にし、さらに反応検出管
の測光時間設定の自由度を高くすることが可能となる。According to the present invention, a plurality of reaction detection tubes arranged on the circumference are moved by a plurality of tubes in one analysis cycle, and a sample is dispensed, a reagent is dispensed, and a reaction detection tube is washed while a reaction detection tube is being moved. In an apparatus for photometry of detection tubes, when the number of reaction detection tubes is N and the number of reaction detection tubes moving in an analysis cycle is M, N ± 1 = A × M (A is an integer of 2 or more), or No common factor other than 1 exists between N and M, and M <N
/ 2 increases the degree of freedom in the device configuration,
The optimum arrangement of the device units is facilitated, and the degree of freedom in setting the photometric time of the reaction detection tube can be increased.
【０００７】[0007]
【実施例】図１は本発明の生化学自動分析装置の一実施
例の構成を示す図、図２は反応進行度合と反応検出管位
置との関係を説明する図である。図中、１は反応検出管
ホルダ、２は光源、３は光検出器、ａ〜ｏは反応検出
管、１０はサンプル分注装置、１１は第１試薬分注装
置、１２は第２試薬分注装置、１３は洗浄装置、１４は
Ａ／Ｄ変換器、１５はＣＰＵ、１６は操作パネル、１７
はＣＲＴ、１８はプリンタである。1 is a diagram showing the configuration of an embodiment of the automatic biochemical analyzer of the present invention, and FIG. 2 is a diagram for explaining the relationship between the degree of reaction progress and the position of a reaction detection tube. In the drawing, 1 is a reaction detection tube holder, 2 is a light source, 3 is a photodetector, a to o are reaction detection tubes, 10 is a sample dispenser, 11 is a first reagent dispenser, and 12 is a second reagent dispenser. Injection device, 13 is a cleaning device, 14 is an A / D converter, 15 is a CPU, 16 is an operation panel, 17
Is a CRT and 18 is a printer.
【０００８】本実施例は１つの分析ラインにおいて、分
析に使用する反応検出管の総数Ｎと１サイクルに検出を
かねて移動する反応検出管の数Ｍの間に、 Ｎ±１＝Ａ×Ｍ（Ａは２以上の整数） の関係を持たせ、かつ１サイクルの移動ピッチは反応検
出管の測光時間を大きくとれるように、Ｍ＜Ｎ／２とし
たものである。なお、図１においては説明の便宜上、Ｎ
＝１５、Ａ＝４、Ｍ＝４として説明する。In this embodiment, in one analysis line, between the total number N of reaction detection tubes used for analysis and the number M of reaction detection tubes moving for one cycle for detection, N ± 1 = A × M ( (A is an integer of 2 or more), and the movement pitch in one cycle is set to M <N / 2 so that the photometric time of the reaction detection tube can be increased. In FIG. 1, for convenience of explanation, N
= 15, A = 4, and M = 4.
【０００９】図１は図５と基本構成は同じであり、図示
しない回転テーブル上に置かれた環状試料ホルダ１には
ａ〜ｏの１５本の反応検出管がセットされ、１サイクル
に４ピッチづつ時計方向に回転するようになっている。
各サイクルの停止時間中にはサンプル分注装置１０で反
応検出管に対してサンプルが分注され、さらに第１試薬
分注装置１１で第１試薬が、第２分注装置１２で第２試
薬がそれぞさ分注され、また測光データが得られた反応
検出管は洗浄装置１３で洗浄されるようになっている。
反応検出管についての測光は、試料ホルダ１がほぼ１回
転する間に反応検出管が光源２と光検出器３を結ぶ光軸
を横切るときに吸光度が検出され、検出信号はＡ／Ｄ変
換器１４でＡ／Ｄ変換されてＣＰＵ１５に取り込まれ
る。ＣＰＵでは所定のデータ処理を行い、操作パネル１
６を操作することにより処理結果がＣＲＴ１７、プリン
タ１８に出力される。FIG. 1 has the same basic structure as that of FIG. 5, and fifteen reaction detection tubes a to o are set in an annular sample holder 1 placed on a rotary table (not shown). Each time it rotates clockwise.
During the stop time of each cycle, the sample is dispensed to the reaction detection tube by the sample dispensing device 10, the first reagent is dispensed by the first reagent dispensing device 11, and the second reagent is dispensed by the second dispensing device 12. Each of the reaction detection tubes from which the photometric data is obtained is washed by the washing device 13.
In the photometry of the reaction detection tube, the absorbance is detected when the reaction detection tube crosses the optical axis connecting the light source 2 and the photodetector 3 while the sample holder 1 makes almost one rotation, and the detection signal is an A / D converter. At 14, the data is A / D converted and taken into the CPU 15. The CPU performs predetermined data processing and operates the operation panel 1.
By operating the device 6, the processing result is output to the CRT 17 and the printer 18.
【００１０】図示するように、反応検出管がサンプル分
注位置から反時計方向に、 ａ→ｂ→ｃ→ｄ→ｅ→ｆ→ｇ→ｈ→ｉ→ｊ→ｋ→ｌ→ｍ→ｎ→ｏ の順序で１５本セットされており、回転テーブルを時計
方向（図の矢印方向）に回転させて１サイクルに４ピッ
チ（Ｍ＝４）つづ進ませるようにしたとき、サンプル分
注位置に順次もたらされる反応検出管の順序は、 ａ→ｅ→ｉ→ｍ→ｂ→ｆ→ｊ→ｎ→ｃ→ｇ→ｋ→ｏ→ｄ→ｈ→ｌ となる。次いで、１サイクルの回転が行われるごとに、
各反応検出管がどの回転位置に移動するかを、例えば図
１の反応検出管ａについてみると図２に示すようにな
る。ここで、番号１は図１における反応検出管ａの停止
位置、番号２は１サイクル回転して反応検出管ａが４ピ
ッチ移動した後の停止位置、以下同様に各番号は１サイ
クル回転ごとの停止位置を示している。この結果は最初
の停止位置の違いだけで他の１４個の反応検出管につい
ても同様である。各サイクルにおいて光源２と光検出器
３とを結ぶ光軸を横切るときに吸光度の検出が行われ
る。そこで、番号１の位置でサンプルを分注し、番号２
の位置で第１試薬を分注し、さらに例えば４サイクル進
んだ番号６の位置で第２試薬を分注する。なお、番号は
反応時間（反応の進行度合い）を示し、番号が大きくな
る程試薬分注から時間が経過して反応が進んだことを意
味している。反応が進んだものは適宜洗浄処理を行う
が、洗浄処理のタイミングはある程度反応が進んでいれ
ば必ずしも最終位置である必要はない。したがって、例
えば番号１１，１５の位置Ｄー１、番号８，１２の位置
Ｄー２、番号９，１３の位置Ｄー３、番号１０，１４の
位置Ｄー４のいずれかで行えばよく、図１では番号１
１，１５の位置Ｄー１に配置している。[0010] As shown in the figure, the reaction detection tube is moved counterclockwise from the sample dispensing position to a → b → c → d → e → f → g → h → i → j → k → l → m → n → When the rotary table is rotated clockwise (in the direction of the arrow in the figure) to advance by 4 pitches (M = 4) in one cycle, it is sequentially set to the sample dispensing position. The order of the resulting reaction detection tubes is as follows: a → e → i → m → b → f → j → n → c → g → k → o → d → h → l. Then, every time one cycle of rotation is performed,
FIG. 2 shows, for example, the reaction detection tube a in FIG. 1 as to which rotational position each reaction detection tube moves. Here, the number 1 is the stop position of the reaction detection tube a in FIG. 1, the number 2 is the stop position after one cycle of rotation and the reaction detection tube a has moved four pitches, and so on. The stop position is shown. This result is the same for the other 14 reaction detection tubes only by the difference in the initial stop position. In each cycle, the absorbance is detected when the light crosses the optical axis connecting the light source 2 and the photodetector 3. Therefore, the sample is dispensed at the position of No. 1 and
The first reagent is dispensed at the position of No. 6, and the second reagent is further dispensed at the position of No. 6, for example, advanced by four cycles. The number indicates the reaction time (degree of progress of the reaction), and the larger the number, the more time has elapsed since the dispensing of the reagent and the more the reaction has progressed. After the reaction has proceeded, the cleaning process is appropriately performed, but the timing of the cleaning process does not necessarily need to be the final position as long as the reaction has progressed to some extent. Therefore, for example, it may be performed at any of the position D-1 of the numbers 11 and 15, the position D-2 of the numbers 8 and 12, the position D-3 of the numbers 9 and 13, and the position D-4 of the numbers 10 and 14. In FIG. 1, number 1
1, 15 are arranged at position D-1.
【００１１】また、反応検出管を２列にして倍の本数に
することにより、Ｎ＝１５，Ａ＝４，Ｍ＝４は変わらな
くても、見掛け上Ｎ＝３０，Ａ＝４，Ｍ＝８とすること
ができる。このように、本実施例では４ピッチづつ移動
させることにより、洗浄装置等の装置ユニットの配置の
自由度が大きくなり、また１サイクル当たりの移動ピッ
チ数が少なくなるために反応検出管１本当たりの測光時
間を長くできるとともに、ピッチ数の変更により容易に
反応検出管１本当たりの測光時間を変えることも可能と
なる。Further, by doubling the number of reaction detection tubes in two rows, N = 15, A = 4, and M = 4 even if N = 15, A = 4, and M = 4 do not change. 8 can be set. As described above, in the present embodiment, by moving four pitches at a time, the degree of freedom in the arrangement of the device units such as the cleaning device is increased, and the number of movement pitches per cycle is reduced. Can be extended, and the photometric time per reaction detection tube can be easily changed by changing the number of pitches.
【００１２】図３はＮ＝２７，Ａ＝４，Ｍ＝７の場合に
ついて、サンプル分注位置にある反応検出管についての
１サイクルごとに移動する位置を表したものである。番
号１はサンプル分注位置であり、図２の場合と同様に番
号が大きいほど反応が進んでいることを意味し、番号１
９，２３，２７の位置Ｄー１、番号１６，２０，２４の
位置Ｄー２、番号１７，２１，２５の位置Ｄー３、番号
１８，２２，２６の位置Ｄー４のように反応が進行し、
かつ反応時間の順番に反応検出管が並ぶので、洗浄機構
を連続して配置することができる。このように、反応検
出管の本数が増えるにつれて洗浄機構設置可能な箇所が
増え、装置ユニット配置の自由度が増して最適配置が容
易になる。FIG. 3 shows the position of the reaction detection tube at the sample dispensing position which moves in each cycle when N = 27, A = 4, and M = 7. The number 1 is a sample dispensing position. As in the case of FIG. 2, the larger the number, the more the reaction is progressing.
Reaction as in position D-1, 9,23,27, position D-2 in numbers 16,20,24, position D-3 in numbers 17,21,25, position D-4 in numbers 18,22,26 Progresses,
In addition, since the reaction detection tubes are arranged in the order of the reaction time, the washing mechanism can be arranged continuously. As described above, as the number of reaction detection tubes increases, the number of places where the washing mechanism can be installed increases, and the degree of freedom in arranging device units increases, facilitating optimal arrangement.
【００１３】なお、上記実施例は反応検出管の総数
（Ｎ）±１と１サイクルに検出をかねて移動する反応検
出管の数Ｍの間に２以上の共通因数がある場合（Ｍ＜Ｎ
／２）であったが、反応検出管の総数Ｎと移動ピッチ数
Ｍの間に２以上の共通因数がなければ１サイクルにＭピ
ッチづつ進むことによりすべての反応検出管についての
処理が実行される。In the above embodiment, there are two or more common factors (M <N) between the total number of reaction detection tubes (N) ± 1 and the number M of reaction detection tubes that move for detection in one cycle.
/ 2), but if there is no common factor of 2 or more between the total number N of reaction detection tubes and the number M of moving pitches, the process proceeds by M pitches in one cycle to execute processing for all reaction detection tubes. You.
【００１４】図４はこのような本発明の他の実施例を説
明するための図である。本実施例は１つの分析ラインに
おいて、分析に使用する反応検出管の総数Ｎと１サイク
ルに検出をかねて移動する反応検出管の数Ｍの間に１以
外の共通な因数を持たない数にしたものである。なお、
本実施例の場合も各反応検出管の測光時間を大きくとれ
るように、Ｍ＜Ｎ／２とする。FIG. 4 is a view for explaining such another embodiment of the present invention. In this example, the number of reaction detection tubes used for analysis in one analysis line and the number M of reaction detection tubes that move for one cycle without detection have no common factor other than 1 between the total number N of reaction detection tubes. Things. In addition,
Also in the case of this embodiment, M <N / 2 is set so that the photometric time of each reaction detection tube can be increased.
【００１５】図示の例は、Ｎ＝２８、Ｍ＝５の場合につ
いてサンプル分注位置にある反応検出管が１サイクルご
とにどの位置へ移動するかを表したものであり、図２、
図３の場合と同様に番号の大きいほど反応が進んだこと
を示している。図から分かるように時計方向に５ピッチ
づつ移動することにより、番号の大きい反応の進んだ箇
所が隣接して現れるので、これらの箇所Ｄー１〜Ｄー６
を選んで洗浄位置とすることにより、装置構成上の自由
度が上がり、最適配置が容易になる。The example shown in FIG. 2 shows to which position the reaction detection tube at the sample dispensing position moves for each cycle when N = 28 and M = 5.
As in the case of FIG. 3, the larger the number, the more the reaction has progressed. As can be seen from the figure, by moving in the clockwise direction by 5 pitches, the places where the reactions with the larger numbers have advanced appear adjacently, and these places D-1 to D-6
Is selected as the cleaning position, the degree of freedom in the apparatus configuration is increased, and the optimum arrangement is facilitated.
【００１６】なお、上記説明では、便宜上反応検出管の
総数Ｎが２桁程度の少ない場合であったが、実際には数
百本のオーダであり、本数が多くなるほど本発明によれ
ば装置構成の自由度が高くなり、図示は省略するがＮ＝
３６０、Ｍ＝２３として構成した例では洗浄位置の設
定、試薬分注位置の設定、検出管自体の吸光度測光用の
水分注位置の設定等について高い自由度が得られ、装置
構成を容易化することができた。In the above description, the total number N of the reaction detection tubes is, for convenience, as small as about two digits. However, the number is actually on the order of several hundreds. Is increased, and N =
In the example in which M is set to 360, M = 23, a high degree of freedom can be obtained for setting the washing position, setting the reagent dispensing position, setting the water injection position for measuring the absorbance of the detection tube itself, and simplifies the device configuration. I was able to.
【００１７】[0017]
【発明の効果】以上のように本発明によれば、反応検出
管の数と反応検出管の移動の数の関係をＮ±１＝Ａ×Ｍ
（Ａは２以上の整数）、或いはＮとＭとの間に１以外の
因数を持たないようにし、かつＭ＜Ｎ／２とすることに
より、装置構成の自由度が高くなり、必要なユニットを
自由に配置して最適構成を得ることが容易となる。ま
た、反応検出管の測光時間を長くすることができ、例え
ば、反応検出管本数を４００本とし、各測光時間を６０
秒とすれば、従来のＮ±１方式では１本当たりの測光時
間は０．１５秒であるのに対して、本発明において、例
えばＭ＝２９の場合には２秒となり、測光時間を大きく
とれ、またＭの値の設定により測光時間も変えられ、測
光時間設定の自由度を高くすることもできる。As described above, according to the present invention, the relationship between the number of reaction detection tubes and the number of movements of the reaction detection tubes is expressed as N ± 1 = A × M.
(A is an integer of 2 or more), or a factor other than 1 is not provided between N and M, and M <N / 2. Can be easily arranged to obtain an optimum configuration. Further, the photometric time of the reaction detection tubes can be lengthened. For example, the number of reaction detection tubes is set to 400, and each photometry time is set to 60.
In the case of seconds, the photometric time per line is 0.15 seconds in the conventional N ± 1 system, whereas in the present invention, for example, when M = 29, it is 2 seconds, and the photometric time is large. Also, the photometric time can be changed by setting the value of M, so that the degree of freedom in setting the photometric time can be increased.
【図１】 本発明の生化学自動分析装置の構成を示す図
である。FIG. 1 is a diagram showing a configuration of a biochemical automatic analyzer of the present invention.
【図２】 反応進行度合と反応検出管位置との関係を説
明する図である。FIG. 2 is a diagram illustrating the relationship between the degree of reaction progress and the position of a reaction detection tube.
【図３】 Ｎ＝２７，Ａ＝４，Ｍ＝７の場合についての
反応進行度合と反応検出管位置との関係を説明する図で
ある。FIG. 3 is a diagram illustrating the relationship between the degree of reaction progress and the position of a reaction detection tube when N = 27, A = 4, and M = 7.
【図４】 本発明の他の実施例を説明する図である。FIG. 4 is a diagram illustrating another embodiment of the present invention.
【図５】 従来の生化学自動分析装置を説明する図であ
る。FIG. 5 is a diagram illustrating a conventional automatic biochemical analyzer.
１…反応検出管ホルダ、２…光源、３…光検出器、ａ〜
ｏ…反応検出管、１０…サンプル分注装置、１１…第１
試薬分注装置、１２…第２試薬分注装置、１３…洗浄装
置、１４…Ａ／Ｄ変換器、１５…ＣＰＵ、１６…操作パ
ネル、１７…ＣＲＴ、１８…プリンタ。DESCRIPTION OF SYMBOLS 1 ... Reaction detection tube holder, 2 ... Light source, 3 ... Photodetector, a-
o: reaction detection tube, 10: sample dispensing device, 11: first
Reagent dispensing device, 12 second reagent dispensing device, 13 cleaning device, 14 A / D converter, 15 CPU, 16 operation panel, 17 CRT, 18 printer.
───────────────────────────────────────────────────── フロントページの続き (72)発明者 斉藤 進 東京都昭島市武蔵野三丁目１番２号日本 電子株式会社内 (58)調査した分野(Int.Cl.6，ＤＢ名) G01N 35/04 G01N 35/02 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Susumu Saito 3-1-2, Musashino, Akishima-shi, Tokyo Japan Electronics Co., Ltd. (58) Field surveyed (Int.Cl. 6 , DB name) G01N 35/04 G01N 35/02
Claims (2)
された複数の反応検出管、所定位置で反応検出管にサン
プルを分注するサンプル分注装置、所定位置で反応検出
管に試薬を分注する試薬分注装置、反応の進行した反応
検出管を洗浄する洗浄装置、反応検出管の移動中に反応
検出管を測光する検出器を備え、１分析サイクルに複数
本の反応検出管を移動させながら反応検出管を測光する
ようにした装置において、反応検出管の数をＮ、１分析
サイクルで移動する反応検出管の数をＭとしたとき、Ｎ
±１＝Ａ×Ｍ（Ａは２以上の整数）であり、かつＭ＜Ｎ
／２とし、反応検出管の移動を繰り返し行って全ての反
応検出管を順次使用して分析するようにしたことを特徴
とする生化学自動分析装置。1. A sample dispensing apparatus for dispensing a sample to a reaction detection tube at a predetermined position, a plurality of reaction detection tubes arranged at least on a circumference of a rotary table, and dispensing a reagent to a reaction detection tube at a predetermined position. A reagent dispensing device, a washing device for washing a reaction detection tube in which a reaction has progressed, and a detector for photometrically detecting the reaction detection tube while the reaction detection tube is moving, and moving a plurality of reaction detection tubes in one analysis cycle. When the number of reaction detection tubes is N and the number of reaction detection tubes moving in an analysis cycle is M in an apparatus configured to perform photometry on the reaction detection tubes,
± 1 = A × M (A is an integer of 2 or more) and M <N
/ 2, wherein the reaction detection tubes are repeatedly moved to perform analysis by sequentially using all the reaction detection tubes.
された複数の反応検出管、所定位置で反応検出管にサン
プルを分注するサンプル分注装置、所定位置で反応検出
管に試薬を分注する試薬分注装置、反応の進行した反応
検出管を洗浄する洗浄装置、反応検出管の移動中に反応
検出管を測光する検出器を備え、１分析サイクルに複数
本の反応検出管を移動させながら反応検出管を測光する
ようにした装置において、反応検出管の数をＮ、１分析
サイクルで移動する反応検出管の数をＭとしたとき、Ｎ
とＭの間に１以外の共通の因数が無く、かつＭ＜Ｎ／２
とし、反応検出管の移動を繰り返し行って全ての反応検
出管を順次使用して分析するようにしたことを特徴とす
る生化学自動分析装置。2. A sample dispensing device for dispensing a sample to a reaction detection tube at a predetermined position, a plurality of reaction detection tubes arranged at least on a circumference of a rotary table, and dispensing a reagent to a reaction detection tube at a predetermined position. A reagent dispensing device, a washing device for washing a reaction detection tube in which a reaction has progressed, and a detector for photometrically detecting the reaction detection tube while the reaction detection tube is moving, and moving a plurality of reaction detection tubes in one analysis cycle. When the number of reaction detection tubes is N and the number of reaction detection tubes moving in an analysis cycle is M in an apparatus configured to perform photometry on the reaction detection tubes,
And M have no common factor other than 1 and M <N / 2
An automatic biochemical analyzer characterized in that the reaction detection tubes are repeatedly moved to perform analysis by sequentially using all the reaction detection tubes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33515791A JP2908923B2 (en) | 1991-12-18 | 1991-12-18 | Biochemical automatic analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33515791A JP2908923B2 (en) | 1991-12-18 | 1991-12-18 | Biochemical automatic analyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05164763A JPH05164763A (en) | 1993-06-29 |
| JP2908923B2 true JP2908923B2 (en) | 1999-06-23 |
Family
ID=18285411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP33515791A Expired - Lifetime JP2908923B2 (en) | 1991-12-18 | 1991-12-18 | Biochemical automatic analyzer |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2908923B2 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE29806593U1 (en) * | 1998-04-09 | 1999-08-12 | Ilmberger Maschinen Und Zahnra | Device for coating a workpiece |
| JP2008224385A (en) | 2007-03-12 | 2008-09-25 | Olympus Corp | Analyzer and analytical method |
| JP5260267B2 (en) * | 2008-12-26 | 2013-08-14 | 株式会社日立ハイテクノロジーズ | Automatic analyzer |
| JP5532425B2 (en) | 2010-08-27 | 2014-06-25 | 株式会社日立ハイテクノロジーズ | Sample holder for charged particle equipment |
| JP6858839B2 (en) * | 2017-03-14 | 2021-04-14 | 株式会社日立ハイテク | Automatic analyzer |
| WO2019073700A1 (en) | 2017-10-12 | 2019-04-18 | 株式会社日立ハイテクノロジーズ | Automated analyzer |
| CN111201439B (en) | 2018-02-26 | 2024-04-05 | 株式会社日立高新技术 | Automatic analysis device |
| JP7179861B2 (en) | 2018-08-28 | 2022-11-29 | 株式会社日立ハイテク | AUTOMATIC ANALYZER AND METHOD THEREOF |
| US20210389337A1 (en) | 2019-01-18 | 2021-12-16 | Hitachi High-Tech Corporation | Automatic analysis device, automatic analysis system, and automatic analysis method for analytes |
-
1991
- 1991-12-18 JP JP33515791A patent/JP2908923B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05164763A (en) | 1993-06-29 |
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