JP2024039967A - Prophylactic or preventive agent, antibacterial agent, and oral composition - Google Patents
Prophylactic or preventive agent, antibacterial agent, and oral composition Download PDFInfo
- Publication number
- JP2024039967A JP2024039967A JP2022144746A JP2022144746A JP2024039967A JP 2024039967 A JP2024039967 A JP 2024039967A JP 2022144746 A JP2022144746 A JP 2022144746A JP 2022144746 A JP2022144746 A JP 2022144746A JP 2024039967 A JP2024039967 A JP 2024039967A
- Authority
- JP
- Japan
- Prior art keywords
- oral
- agents
- honey
- antibacterial agent
- therapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003242 anti bacterial agent Substances 0.000 title claims abstract description 25
- 239000000203 mixture Substances 0.000 title claims abstract description 12
- 239000003795 chemical substances by application Substances 0.000 title claims description 25
- 230000003449 preventive effect Effects 0.000 title claims description 7
- 230000000069 prophylactic effect Effects 0.000 title claims description 6
- 235000012907 honey Nutrition 0.000 claims abstract description 47
- 241000894006 Bacteria Species 0.000 claims abstract description 35
- 235000015001 Cucumis melo var inodorus Nutrition 0.000 claims abstract description 27
- 240000002495 Cucumis melo var. inodorus Species 0.000 claims abstract description 27
- 201000010099 disease Diseases 0.000 claims abstract description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 21
- 241000605862 Porphyromonas gingivalis Species 0.000 claims abstract description 19
- 208000028169 periodontal disease Diseases 0.000 claims abstract description 14
- 239000004480 active ingredient Substances 0.000 claims abstract description 9
- 206010003210 Arteriosclerosis Diseases 0.000 claims abstract description 5
- 208000011775 arteriosclerosis disease Diseases 0.000 claims abstract description 5
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 5
- 206010006326 Breath odour Diseases 0.000 claims abstract description 4
- 206010012289 Dementia Diseases 0.000 claims abstract description 4
- 208000002925 dental caries Diseases 0.000 claims abstract description 4
- 239000003814 drug Substances 0.000 claims description 24
- 229940124597 therapeutic agent Drugs 0.000 claims description 21
- 235000011613 Pinus brutia Nutrition 0.000 claims description 9
- 241000018646 Pinus brutia Species 0.000 claims description 9
- 235000008331 Pinus X rigitaeda Nutrition 0.000 claims description 8
- 235000013305 food Nutrition 0.000 claims description 8
- 239000002324 mouth wash Substances 0.000 claims description 4
- 239000000865 liniment Substances 0.000 claims description 3
- 229940051866 mouthwash Drugs 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 239000013589 supplement Substances 0.000 claims description 3
- 238000013268 sustained release Methods 0.000 claims description 3
- 239000012730 sustained-release form Substances 0.000 claims description 3
- 239000000606 toothpaste Substances 0.000 claims description 3
- 230000001055 chewing effect Effects 0.000 claims description 2
- 229940040145 liniment Drugs 0.000 claims description 2
- 229940034610 toothpaste Drugs 0.000 claims description 2
- 230000003405 preventing effect Effects 0.000 abstract description 4
- 230000002401 inhibitory effect Effects 0.000 abstract description 2
- 208000032139 Halitosis Diseases 0.000 abstract 1
- 239000007788 liquid Substances 0.000 description 14
- 230000002554 disease preventive effect Effects 0.000 description 10
- 239000012895 dilution Substances 0.000 description 5
- 238000010790 dilution Methods 0.000 description 5
- 241000257303 Hymenoptera Species 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 230000003239 periodontal effect Effects 0.000 description 3
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 240000003553 Leptospermum scoparium Species 0.000 description 2
- 235000016887 Leptospermum scoparium Nutrition 0.000 description 2
- 240000007472 Leucaena leucocephala Species 0.000 description 2
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 2
- 241000219492 Quercus Species 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 230000006806 disease prevention Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000007937 lozenge Substances 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 229940109850 royal jelly Drugs 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 241000218642 Abies Species 0.000 description 1
- 241000157282 Aesculus Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 241001124076 Aphididae Species 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 241000190888 Capnocytophaga gingivalis Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- 241000220150 Eucryphia lucida Species 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 241000258937 Hemiptera Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001135221 Prevotella intermedia Species 0.000 description 1
- 241000241413 Propolis Species 0.000 description 1
- 241001135235 Tannerella forsythia Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 240000007313 Tilia cordata Species 0.000 description 1
- 241000589892 Treponema denticola Species 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000036523 atherogenesis Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000021438 curry Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 235000021186 dishes Nutrition 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 235000010181 horse chestnut Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- -1 mouth freshener Substances 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229940069949 propolis Drugs 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Diabetes (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Biotechnology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Insects & Arthropods (AREA)
- Birds (AREA)
- Nutrition Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Vascular Medicine (AREA)
- Medical Informatics (AREA)
Abstract
Description
本発明は、口腔細菌を原因とする疾患の予防又は治療剤、及び抗菌剤、並びに、予防若しくは治療剤又は抗菌剤を含有する口腔用組成物に関する。 The present invention relates to a prophylactic or therapeutic agent for diseases caused by oral bacteria, an antibacterial agent, and an oral composition containing the prophylactic or therapeutic agent or the antibacterial agent.
歯周病は、歯肉炎又は歯槽膿漏等、歯周組織に炎症を引き起こす症状をともなう疾患である。歯周病の原因菌である口腔細菌としては、プレボテラ・インターメディア（Prevotella intermedia）、タンネレラ・フォーサイセンシス（Tannerella forsythensis）、トレポネマ・デンティコラ（Treponema denticola）等が知られているが、慢性歯周病のレッド・コンプレックス（最重要歯周病原細菌）はプロフィロモナス・ジンジバリス（Porphyromonas gingivalis. 以下、「ジンジバリス菌」と記す。）である。歯周病の予防にはプラークコントロールが有用である。歯周病の中には、プラークを原因としないものがあり、重症化した場合には、抗生物質による化学的療法等を受けなくてはならない。患者に投与される薬剤には、副作用として種々の消化器系疾患を誘発する懸念があり、安全な原因菌の除去剤が望まれていた。また、最近では、ジンジバリス菌は、歯周病以外の疾患との関連も多く報告されている。例えば、ジンジバリス菌成分が、アルツハイマー病患者の脳内で検出されたことから、アルツハイマー病を引き起こす一連の事象に関与している可能性が指摘されている（非特許文献１）。また、ジンジバリス菌等の歯周病原因菌が心血管疾患発症の要因である可能性があること（非特許文献２）、及び、ジンジバリス菌が脳梗塞や狭心症、心筋梗塞などを引き起こすアテローム性動脈硬化症という炎症反応を悪化させる可能性があること（非特許文献３）も指摘されている。さらには、歯周病菌の存在と糖尿病発症との強い相関があること（非特許文献４）も報告されている。 Periodontal disease is a disease accompanied by symptoms that cause inflammation in periodontal tissue, such as gingivitis or alveolar pyorrhea. Oral bacteria that cause periodontal disease include Prevotella intermedia, Tannerella forsythensis, and Treponema denticola. The disease's red complex (the most important periodontal pathogen) is Prophyromonas gingivalis (hereinafter referred to as "gingivalis bacteria"). Plaque control is useful for preventing periodontal disease. Some periodontal diseases are not caused by plaque, and if the disease becomes severe, chemotherapy with antibiotics must be taken. There is a concern that drugs administered to patients may induce various gastrointestinal diseases as side effects, and a safe agent for removing causative bacteria has been desired. Furthermore, recently, there have been many reports that P. gingivalis is associated with diseases other than periodontal disease. For example, since B. gingivalis components have been detected in the brains of Alzheimer's disease patients, it has been pointed out that they may be involved in a series of events that cause Alzheimer's disease (Non-Patent Document 1). In addition, bacteria that cause periodontal disease, such as B. gingivalis, may be a factor in the development of cardiovascular diseases (Non-patent Document 2), and B. gingivalis causes atherogenesis, which causes cerebral infarction, angina pectoris, myocardial infarction, etc. It has also been pointed out that it may aggravate the inflammatory reaction called sexual arteriosclerosis (Non-Patent Document 3). Furthermore, it has been reported that there is a strong correlation between the presence of periodontal disease bacteria and the onset of diabetes (Non-Patent Document 4).
ジンジバリス菌と様々な疾患との関連が指摘される中で、ジンジバリス菌に作用して、上記のような疾患を予防又は治療することのできる予防又は治療剤への需要が高まっている。これに対し、例えば、特許文献１には、ストレプトコッカス・フェカリス（Streptococcus faecalis）菌を含有した口腔用組成物が歯周病関連細菌のジンジバリス菌類に対して選択的な作用を示し、口腔内フローラを良い環境に導くことが提示されている。 As the relationship between P. gingivalis and various diseases has been pointed out, there is an increasing demand for prophylactic or therapeutic agents that can act on P. gingivalis and prevent or treat the above-mentioned diseases. On the other hand, for example, Patent Document 1 discloses that an oral composition containing Streptococcus faecalis exhibits a selective effect on periodontal disease-related bacteria, Gingivalis, and inhibits oral flora. It is proposed to lead to a good environment.
ジンジバリス菌に作用して効果を発揮する成分をハチミツ類に限定すると、ヤハシハチミツ及び／又はローヤルゼリーがジンジバリス菌の除菌作用を示し、歯周疾患の予防又は改善剤となることが報告されている（特許文献２）。また、マヌカハニーはジンジバリス菌に対する抗菌作用が、一般的な花ハチミツよりも高いことも報告されている（非特許文献５）。 If we limit the ingredients that are effective against P. gingivalis to honey, it has been reported that Yahashi honey and/or royal jelly exhibits a bactericidal effect on P. gingivalis and serves as an agent for preventing or improving periodontal disease ( Patent Document 2). It has also been reported that Manuka honey has a higher antibacterial effect against Gingivalis bacteria than general flower honey (Non-Patent Document 5).
本発明は、口腔細菌を原因とする疾患に対する新規の予防又は治療剤、及び口腔細菌に対する新規の抗菌剤を提供することを目的とする。 An object of the present invention is to provide a new preventive or therapeutic agent for diseases caused by oral bacteria, and a new antibacterial agent for oral bacteria.
本発明は、上記課題を解決するために鋭意研究を重ねた結果、甘露ハチミツを有効成分として用いることで、一般的な花ハチミツよりもジンジバリス菌に代表される口腔細菌の増殖を低濃度で抑制できることを見出し、本発明を完成するに至った。 As a result of intensive research to solve the above problems, the present invention uses honeydew honey as an active ingredient to suppress the growth of oral bacteria such as Gingivalis at a lower concentration than general flower honey. We have discovered that this can be done, and have completed the present invention.
すなわち、本発明は、口腔細菌が原因で発症する疾病の予防又は治療剤であって、前記疾患が、歯周病、虫歯、口臭、認知症、糖尿病、動脈硬化症から選択される１種以上である、甘露ハチミツを有効成分とする疾病の予防又は治療剤である。さらに別の発明は、甘露ハチミツを有効成分とする、口腔細菌に対する抗菌剤である。口腔細菌は、ポルフィロモナス・ジンジバリスであり得る。 That is, the present invention is a preventive or therapeutic agent for diseases caused by oral bacteria, wherein the disease is one or more selected from periodontal disease, tooth decay, bad breath, dementia, diabetes, and arteriosclerosis. This is a disease preventive or therapeutic agent containing honeydew honey as an active ingredient. Yet another invention is an antibacterial agent against oral bacteria that contains honeydew honey as an active ingredient. The oral bacterium can be Porphyromonas gingivalis.
また、本発明は、甘露ハチミツが、松の木由来である疾病の予防又は治療剤及び抗菌剤であり、疾病の予防又は治療剤及び抗菌剤を含む歯磨き剤、洗口剤、塗布剤、マウススプレー、貼付剤、シート剤、口腔内徐放剤、咀嚼剤、口腔内溶解剤、口腔内崩壊剤、義歯ケア剤、舌ケア剤、口中清涼剤、トローチ剤、含嗽剤、食品組成物、サプリメント、及びドリンク剤から選ばれる口腔用組成物である。 The present invention also relates to an oral composition comprising honeydew honey, a disease preventive or therapeutic agent and an antibacterial agent derived from a pine tree, and the oral composition is selected from toothpaste, mouthwash, liniment, mouth spray, patch, sheet, oral sustained release agent, chewable agent, oral dissolving agent, oral disintegrating agent, denture care agent, tongue care agent, mouth freshener, lozenge, mouthwash, food composition, supplement, and drink, which contains the disease preventive or therapeutic agent and the antibacterial agent.
甘露ハチミツは、すでに食品として全世界で食経験のある天然物質であり、ジンジバリス菌等の口腔細菌に対して低濃度で優れた抗菌作用を有している。したがって、本発明を用いた場合では、耐性菌出現のリスクが低く、ジンジバリス菌等の口腔細菌の増殖の抑制や、ジンジバリス菌等の口腔細菌に関連する疾患の予防または治療に非常に有用である。 Honeydew honey is a natural substance that has already been eaten as a food all over the world, and has excellent antibacterial activity at low concentrations against oral bacteria such as Gingivalis bacteria. Therefore, when the present invention is used, the risk of emergence of resistant bacteria is low, and it is extremely useful for suppressing the growth of oral bacteria such as P. gingivalis and for preventing or treating diseases related to oral bacteria such as P. gingivalis. .
以下、本発明の好適な実施形態について詳細に説明する。ただし、本発明は以下の実施形態に限定されるものではない。 Hereinafter, preferred embodiments of the present invention will be described in detail. However, the present invention is not limited to the following embodiments.
本発明において、抗菌剤とは、歯周病の最重要歯周病原細菌であると言われているポルフィロモナス・ジンジバリス等の口腔細菌の増殖を抑制することができる組成物を意味する。本発明の抗菌剤は、ジンジバリス菌等の口腔細菌に関連する疾患の予防又は治療のために用いることができる。 In the present invention, the antibacterial agent refers to a composition that can inhibit the growth of oral bacteria such as Porphyromonas gingivalis, which is said to be the most important periodontal pathogen for periodontal disease. The antibacterial agent of the present invention can be used for the prevention or treatment of diseases associated with oral bacteria such as P. gingivalis.
本発明において有効成分として用いられる甘露ハチミツは、別名として「甘露蜜」、「ハニーデューハニー」と呼ばれ、ヨーロッパでは「森の蜜」とも呼ばれる樹木由来のハチミツである。甘露ハチミツは、樹液を食べるアブラムシやカイガラムシが分泌する糖分の高い甘露をミツバチが集めて作られたものである。利用される主な樹木は、松の木、オーク、菩提樹、アカシア、レザーウッド、トチ、樫の木、もみの木などであり、主にヨーロッパやアジアの一部で生産されている。国内では、小笠原諸島で生産されている「島ハチミツ」の多くが甘露ハチミツである。一般的には、ミネラルやポリフェノールが豊富な希少なハチミツとして知られている。 The honeydew honey used as an active ingredient in the present invention is also called "honeydew honey" or "honeydew honey" and is a tree-derived honey that is also called "forest honey" in Europe. Honeydew honey is made by bees collecting high-sugar honeydew secreted by aphids and scale insects that feed on tree sap. The main trees used are pine, oak, linden, acacia, leatherwood, horse chestnut, oak, and fir, and are mainly produced in Europe and parts of Asia. In Japan, much of the ``island honey'' produced in the Ogasawara Islands is honeydew honey. It is generally known as a rare honey rich in minerals and polyphenols.
本発明の疾患の予防又は治療剤及び抗菌剤は、甘露ハチミツを有効成分とする。ハチミツには、花の蜜をミツバチが集めて作る花ハチミツと、樹木由来の樹液を食べる昆虫が分泌する甘露をミツバチが集めて作る甘露ハチミツの、大きく分けて２種類が存在する。本発明では、甘露ハチミツであれば特に限定はされないが、松の木由来のパインハニーが好ましく、ギリシャ産もしくはトルコ産のパインハニーがさらに好ましい。 The disease preventive or therapeutic agent and antibacterial agent of the present invention contain honeydew honey as an active ingredient. There are two main types of honey: flower honey, which is made by bees collecting nectar from flowers, and honeydew honey, which is made by bees collecting honeydew secreted by insects that feed on tree sap. In the present invention, honeydew honey is not particularly limited as long as it is honey, but pine honey derived from pine trees is preferred, and pine honey from Greece or Turkey is more preferred.
本発明の疾患の予防又は治療剤及び抗菌剤は、ハチミツを有効成分としているため、一般的な使用方法として任意の食品素材、例えば、牛乳、コーヒー、紅茶や果汁等の飲料、ヨーグルト等の乳製品、パンやサンドウィッチ等の食品、カレーなど各種料理に調味料として添加して用いることができる。 Since the disease prevention or treatment agent and antibacterial agent of the present invention contain honey as an active ingredient, they can be generally used with any food material, such as milk, coffee, drinks such as tea and fruit juice, and milk such as yogurt. It can be added as a seasoning to products, foods such as bread and sandwiches, and various dishes such as curry.
また、本発明の疾患の予防又は治療剤及び抗菌剤は、歯磨き剤、洗口剤、塗布剤、マウススプレー、貼付剤、シート剤、口腔内徐放剤、咀嚼剤、口腔内溶解剤、口腔内崩壊剤、義歯ケア剤、舌ケア剤、口中清涼剤、トローチ剤、含嗽剤、食品組成物、サプリメント、及びドリンク剤から選ばれる口腔用組成物として用いることができる。 In addition, the preventive or therapeutic agent for diseases and the antibacterial agent of the present invention include toothpastes, mouth washes, liniments, mouth sprays, patches, sheets, oral sustained release agents, chewing agents, oral dissolving agents, oral It can be used as an oral composition selected from internally disintegrating agents, denture care agents, tongue care agents, mouth fresheners, troches, gargles, food compositions, supplements, and drinks.
本発明の疾病の予防又は治療剤及び抗菌剤は、固体、液体、ペースト等のいずれの形態であっても良く、タブレット、カプセル剤、丸剤、散剤、細粒剤、顆粒剤、液剤等の形態であっても良い。これらの製剤は、薬理学的又は生理学的に許容される添加物（例えば、賦形剤、滑沢剤、結合剤、崩壊剤、安定剤、懸濁化剤、乳化剤、溶解補助剤等）を混合して製造することもできる。 The disease preventive or therapeutic agent and antibacterial agent of the present invention may be in any form such as solid, liquid, or paste, and may be in the form of tablets, capsules, pills, powders, fine granules, granules, liquids, etc. It may be a form. These preparations contain pharmacologically or physiologically acceptable additives (e.g., excipients, lubricants, binders, disintegrants, stabilizers, suspending agents, emulsifiers, solubilizing agents, etc.). They can also be produced by mixing.
本発明の疾病の予防又は治療剤及び抗菌剤は、医薬品、医薬部外品、化粧品、食品、飼料又はそれらの成分などとして使用することができる。 The disease preventive or therapeutic agent and antibacterial agent of the present invention can be used as pharmaceuticals, quasi-drugs, cosmetics, foods, feeds, or components thereof.
さらに、本発明の疾患の予防又は治療剤及び抗菌剤においては、甘露ハチミツが、成人１日当たりの摂取量が０.０１～１００ｇとなるように用いられることが好ましい。疾患の予防剤又は治療剤及び抗菌剤が、錠剤、トローチ剤、顆粒、ガム、グミ等の固形の形態の場合は、甘露ハチミツが、総質量に対して１～８０重量％の範囲で配合されることが好ましい。また、ペースト、液状の場合に、甘露ハチミツの濃度が、総重量に対して０．０１～８０重量％の範囲で配合されることが好ましい。さらに、本発明の疾患の予防剤又は治療剤及び抗菌剤を経口摂取した直後の人又は動物の唾液中に、甘露ハチミツが２～１００ｍｇ/ｍｌの範囲で存在するように配合することが、さらに好ましい。 Furthermore, in the disease prevention or treatment agent and antibacterial agent of the present invention, honeydew honey is preferably used in an amount of 0.01 to 100 g per day for an adult. When the disease preventive or therapeutic agent and antibacterial agent are in solid form such as tablets, lozenges, granules, gums, gummies, etc., honeydew honey is blended in an amount of 1 to 80% by weight based on the total mass. It is preferable that Further, in the case of a paste or a liquid, the concentration of honeydew honey is preferably blended in a range of 0.01 to 80% by weight based on the total weight. Furthermore, the disease preventive or therapeutic agent and the antibacterial agent of the present invention may be blended so that honeydew honey is present in the saliva of a person or animal in a range of 2 to 100 mg/ml immediately after oral ingestion. preferable.
本発明の疾患の予防又は治療剤及び抗菌剤には種々の添加物、例えば食品の場合には、各種栄養素、種々のビタミン、ミネラル、フラボノイド類、ポリフェノール類、アミノ酸、食物繊維、多価不飽和脂肪酸、分散剤、及び乳化剤等の安定剤、着色料、香料、甘味料、呈味成分、フレーバー、その他のハチミツ成分、ローヤルゼリー、プロポリス等を配合することができる。 The disease preventive or therapeutic agent and antibacterial agent of the present invention include various additives, for example, in the case of foods, various nutrients, various vitamins, minerals, flavonoids, polyphenols, amino acids, dietary fiber, polyunsaturated Stabilizers such as fatty acids, dispersants, and emulsifiers, colorants, fragrances, sweeteners, taste components, flavors, other honey components, royal jelly, propolis, and the like can be blended.
本発明の疾患の予防剤又は治療剤及び抗菌剤は、安全性が高く、低濃度でジンジバリス菌等の口腔細菌を除去することができることから、ジンジバリス菌等の口腔細菌を原因とする各種疾患を予防又は治療するために用いることができる。ジンジバリス菌等の口腔細菌を原因とする疾患としては、歯周病、虫歯、口臭、認知症、糖尿病、動脈硬化症などが挙げられる。また、これら疾患による合併症についても含まれる。 The disease preventive or therapeutic agent and antibacterial agent of the present invention are highly safe and can eliminate oral bacteria such as Gingivalis bacteria at low concentrations, so they are effective against various diseases caused by oral bacteria such as Gingivalis bacteria. It can be used for prevention or treatment. Diseases caused by oral bacteria such as C. gingivalis include periodontal disease, tooth decay, bad breath, dementia, diabetes, and arteriosclerosis. It also includes complications caused by these diseases.
以下、実施例を通じて本発明をさらに詳細に説明する。ただし、本発明の範囲がこれら実施例に限定されるものではない。 Hereinafter, the present invention will be explained in more detail through Examples. However, the scope of the present invention is not limited to these Examples.
Porphyromonas gingivalis (JCM 12257)、及び、Porphyromonas gingivalis (ATCC 49417)をNV加ABHK寒天培地（日水製薬製）に接種し、３７℃、嫌気条件下で７日間培養後、生理食塩水を用いて、菌数が108/mLになるように調製したものを試験菌液とした。変法GAM液体培地（日水製薬製）に試験菌液を接種し、３７℃、嫌気条件で４日間培養した。４日間の培養後、菌の発育有無を肉眼で観察して、ＭＩＣ（最少発育阻止濃度）を判定した。 Porphyromonas gingivalis (JCM 12257) and Porphyromonas gingivalis (ATCC 49417) were inoculated onto NV-added ABHK agar medium (manufactured by Nissui Pharmaceutical Co., Ltd.), and after culturing at 37°C under anaerobic conditions for 7 days, using physiological saline, The test bacteria solution was prepared so that the number of bacteria was 10 8 /mL. The test bacterial solution was inoculated into a modified GAM liquid medium (manufactured by Nissui Pharmaceutical Co., Ltd.) and cultured at 37°C under anaerobic conditions for 4 days. After culturing for 4 days, the presence or absence of bacterial growth was visually observed to determine the MIC (minimum inhibitory concentration).
甘露ハチミツであるトルコ産松の木由来パインハニーを２０重量％となるように液体培地に混合した。これを試験試料として、液体培地を用いて２倍希釈系列を合計１０段階調製した。その結果を表１、表２、表３に示す。JCM 12257に対するＭＩＣは、０．２６重量％であり、ATCC 49417に対するＭＩＣは０．３１重量％であった。 Pine honey derived from Turkish pine trees, which is honeydew honey, was mixed into a liquid medium at a concentration of 20% by weight. Using this as a test sample, a total of 10 2-fold dilution series were prepared using a liquid medium. The results are shown in Tables 1, 2, and 3. The MIC for JCM 12257 was 0.26% by weight and the MIC for ATCC 49417 was 0.31% by weight.
甘露ハチミツであるギリシャ産オーク由来オークハニーを２０重量％となるように液体培地に混合した。これを試験試料として、液体培地を用いて２倍希釈系列を合計１０段階調製した。その結果を表１に示す。JCM 12257に対するＭＩＣは、０．６２重量％であり、ATCC 49417に対するＭＩＣは０．６２重量％であった。 Oak honey derived from Greek oak, which is honeydew honey, was mixed into the liquid medium at a concentration of 20% by weight. Using this as a test sample, a total of 10 2-fold dilution series were prepared using a liquid medium. The results are shown in Table 1. The MIC for JCM 12257 was 0.62% by weight and the MIC for ATCC 49417 was 0.62% by weight.
オーストリア産もみの木由来の甘露ハチミツを２０重量％となるように液体培地に混合した。これを試験試料として、液体培地を用いて２倍希釈系列を合計１０段階調製した。その結果を表１に示す。JCM 12257に対するＭＩＣは、０．３１重量％であり、ATCC 49417に対するＭＩＣは０．６２重量％であった。 Honeydew honey derived from Austrian fir trees was mixed into a liquid medium at a concentration of 20% by weight. Using this as a test sample, a total of 10 2-fold dilution series were prepared using a liquid medium. The results are shown in Table 1. The MIC for JCM 12257 was 0.31% by weight and the MIC for ATCC 49417 was 0.62% by weight.
花ハチミツである国内産アカシアハチミツを２０重量％となるように液体培地に混合した。これを試験試料として、液体培地を用いて２倍希釈系列を合計１０段階調製した。その結果を表１に示す。JCM 12257に対するＭＩＣは、５重量％であり、ATCC 49417に対するＭＩＣは５重量％であった。 Domestic acacia honey, which is flower honey, was mixed into the liquid medium at a concentration of 20% by weight. Using this as a test sample, a total of 10 2-fold dilution series were prepared using a liquid medium. The results are shown in Table 1. The MIC for JCM 12257 was 5% by weight and the MIC for ATCC 49417 was 5% by weight.
花ハチミツであるニュージーランド産マヌカハニー５７３＋／ＵＭＦ１６＋を２０重量％となるように液体培地に混合した。これを試験試料として、液体培地を用いて２倍希釈系列を合計１０段階調製した。その結果を表１に示す。JCM 12257に対するＭＩＣは、２．５重量％であり、ATCC 49417に対するＭＩＣは２．５重量％であった。 New Zealand Manuka Honey 573+/UMF16+, which is flower honey, was mixed into the liquid medium at a concentration of 20% by weight. Using this as a test sample, a total of 10 2-fold dilution series were prepared using a liquid medium. The results are shown in Table 1. The MIC for JCM 12257 was 2.5% by weight and the MIC for ATCC 49417 was 2.5% by weight.
Claims (7)
A toothpaste, a mouthwash, a liniment, a mouth spray, or a patch containing the prophylactic or therapeutic agent according to any one of claims 1 to 3, or the antibacterial agent according to any one of claims 4 to 6. , sheet agents, oral sustained release agents, chewing agents, oral dissolving agents, oral disintegrating agents, denture care agents, tongue care agents, mouth fresheners, troches, gargling agents, food compositions, supplements, and drinks. Oral composition selected from.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022144746A JP7198547B1 (en) | 2022-09-12 | 2022-09-12 | Prophylactic or therapeutic agents, antibacterial agents, and oral compositions |
| PCT/JP2023/031000 WO2024057898A1 (en) | 2022-09-12 | 2023-08-28 | Prophylactic or preventive agent, antibacterial agent, and oral composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022144746A JP7198547B1 (en) | 2022-09-12 | 2022-09-12 | Prophylactic or therapeutic agents, antibacterial agents, and oral compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP7198547B1 JP7198547B1 (en) | 2023-01-04 |
| JP2024039967A true JP2024039967A (en) | 2024-03-25 |
Family
ID=84777473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022144746A Active JP7198547B1 (en) | 2022-09-12 | 2022-09-12 | Prophylactic or therapeutic agents, antibacterial agents, and oral compositions |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP7198547B1 (en) |
| WO (1) | WO2024057898A1 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170072024A1 (en) * | 2014-05-14 | 2017-03-16 | Melipharm | Antimicrobial composition comprising a carbohydrate, glucose oxidase and zinc oxide |
-
2022
- 2022-09-12 JP JP2022144746A patent/JP7198547B1/en active Active
-
2023
- 2023-08-28 WO PCT/JP2023/031000 patent/WO2024057898A1/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170072024A1 (en) * | 2014-05-14 | 2017-03-16 | Melipharm | Antimicrobial composition comprising a carbohydrate, glucose oxidase and zinc oxide |
Non-Patent Citations (4)
| Title |
|---|
| INTERNATIONAL JOURNAL OF VETERINARY SCIENCES AND ANIMAL HUSBANDRY, vol. 1(2), JPN6022046168, 2016, pages 7 - 10, ISSN: 0004911253 * |
| JPN J ORAL BIOL., vol. 36, JPN6022046169, 1994, pages 263 - 273, ISSN: 0004911254 * |
| LEBENSM-WISS U-TECHNOL., vol. 30, JPN6022046166, 1997, pages 748 - 753, ISSN: 0004911252 * |
| SCIENTIFIC REPORTS, vol. 8, JPN6022046165, 2018, pages 1 - 9, ISSN: 0004911251 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2024057898A1 (en) | 2024-03-21 |
| JP7198547B1 (en) | 2023-01-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Vahid-Dastjerdi et al. | Effect of Rhus coriaria L. water extract on five common oral bacteria and bacterial biofilm formation on orthodontic wire | |
| Narayan et al. | Punica granatum (Pomegranate) fruit and its relevance in Oral Hygiene | |
| KR20170141034A (en) | Composition for prevention or treatment of dental disease comprising Panax ginseng extract | |
| JP7198547B1 (en) | Prophylactic or therapeutic agents, antibacterial agents, and oral compositions | |
| US20050152852A1 (en) | Use of antibacterial component extracted from cacao mass for inhibiting the growth of periodontal bacteria | |
| KR20200050801A (en) | Oral composition containing eugenol and bamboo salt | |
| KR101645721B1 (en) | Composition comprising mastic for preventing and treating gastric diseases | |
| KR20170141053A (en) | Composition for prevention or treatment of dental disease comprising an extract of Gardenia jasminoides | |
| KR20180055521A (en) | Composition for prevention or treatment of oral disease comprising icaritin | |
| RU2618889C1 (en) | Mouthwash agent having antiinflammatory, antimicrobial, wound-healing effect | |
| KR20170141027A (en) | Composition for prevention or treatment of dental disease comprising an extract of Astragalus membranaceus | |
| KR20150136656A (en) | Compositions for preventing, improving or treating periodontal diseases | |
| RU2777153C1 (en) | Composition for oral care for patients with metabolic disorders | |
| JP6918529B2 (en) | Oral composition | |
| KR20180047705A (en) | Composition for prevention or treatment of oral disease comprising Forsythiae Fructus extract | |
| KR20180047703A (en) | Composition for prevention or treatment of oral disease comprising Nelumbo Nucifera extract | |
| KR20180046247A (en) | Composition for prevention or treatment of oral disease comprising Verbascoside | |
| US20160213604A1 (en) | Compositions and methods for reducing caries-causing oral bacteria | |
| Parolia et al. | Recent update on application of propolis as an adjuvant natural medication in management of gum diseases and drug delivery approaches | |
| KR20170141057A (en) | Composition for prevention or treatment of dental disease comprising an extract of Daphne genkwa | |
| KR20180046250A (en) | Composition for prevention or treatment of oral disease comprising Astilbin | |
| KR20180046244A (en) | Composition for prevention or treatment of oral disease comprising Cordycepin | |
| KR20180047704A (en) | Composition for prevention or treatment of oral disease comprising Scutellaria baicalensis extract | |
| KR102115575B1 (en) | Composition for prevention or treatment of oral disease comprising extracts of Artemisiae Annuae and Bamboo salts | |
| KR20170134123A (en) | Composition for prevention or treatment of dental disease comprising astragaloside |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20220912 |
|
| A871 | Explanation of circumstances concerning accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A871 Effective date: 20220912 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20221101 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20221125 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20221209 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20221212 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7198547 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |