JP2024000733A - Emulsion composition - Google Patents
Emulsion composition Download PDFInfo
- Publication number
- JP2024000733A JP2024000733A JP2022099599A JP2022099599A JP2024000733A JP 2024000733 A JP2024000733 A JP 2024000733A JP 2022099599 A JP2022099599 A JP 2022099599A JP 2022099599 A JP2022099599 A JP 2022099599A JP 2024000733 A JP2024000733 A JP 2024000733A
- Authority
- JP
- Japan
- Prior art keywords
- oil
- less
- mass
- emulsified
- emulsified composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 58
- 239000000839 emulsion Substances 0.000 title abstract description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 59
- -1 hydroxypropyl group Chemical group 0.000 claims abstract description 55
- 239000002562 thickening agent Substances 0.000 claims abstract description 21
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 20
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 20
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 20
- 239000004094 surface-active agent Substances 0.000 claims abstract description 16
- 239000003921 oil Substances 0.000 claims description 25
- 235000019198 oils Nutrition 0.000 claims description 25
- 239000003795 chemical substances by application Substances 0.000 claims description 18
- 229920002678 cellulose Polymers 0.000 claims description 16
- 239000001913 cellulose Substances 0.000 claims description 16
- 239000004359 castor oil Substances 0.000 claims description 13
- 235000019438 castor oil Nutrition 0.000 claims description 13
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 13
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 11
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 7
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 6
- 239000008158 vegetable oil Substances 0.000 claims description 6
- 230000001804 emulsifying effect Effects 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 16
- 239000000194 fatty acid Substances 0.000 description 16
- 229930195729 fatty acid Natural products 0.000 description 16
- 235000010980 cellulose Nutrition 0.000 description 15
- 238000011156 evaluation Methods 0.000 description 11
- 230000000249 desinfective effect Effects 0.000 description 8
- 239000003205 fragrance Substances 0.000 description 7
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 7
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 241000700605 Viruses Species 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 239000002202 Polyethylene glycol Substances 0.000 description 5
- 229920001214 Polysorbate 60 Polymers 0.000 description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
- 239000003242 anti bacterial agent Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- 230000002378 acidificating effect Effects 0.000 description 4
- 238000004220 aggregation Methods 0.000 description 4
- 230000002776 aggregation Effects 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 238000004945 emulsification Methods 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- 244000309711 non-enveloped viruses Species 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 239000004166 Lanolin Substances 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000000645 desinfectant Substances 0.000 description 3
- 229930182470 glycoside Natural products 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 235000019388 lanolin Nutrition 0.000 description 3
- 229940039717 lanolin Drugs 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- ULDHMXUKGWMISQ-VIFPVBQESA-N (+)-carvone Chemical compound CC(=C)[C@H]1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-VIFPVBQESA-N 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 2
- 240000000912 Macadamia tetraphylla Species 0.000 description 2
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- ZYEMGPIYFIJGTP-UHFFFAOYSA-N O-methyleugenol Chemical compound COC1=CC=C(CC=C)C=C1OC ZYEMGPIYFIJGTP-UHFFFAOYSA-N 0.000 description 2
- 235000019482 Palm oil Nutrition 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 2
- 244000299461 Theobroma cacao Species 0.000 description 2
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 2
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 2
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 2
- 239000010775 animal oil Substances 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 235000001046 cacaotero Nutrition 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- JOZKFWLRHCDGJA-UHFFFAOYSA-N citronellol acetate Chemical compound CC(=O)OCCC(C)CCC=C(C)C JOZKFWLRHCDGJA-UHFFFAOYSA-N 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000010696 ester oil Substances 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 235000008524 evening primrose extract Nutrition 0.000 description 2
- 239000010475 evening primrose oil Substances 0.000 description 2
- 229940089020 evening primrose oil Drugs 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 2
- 239000010466 nut oil Substances 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- 239000002540 palm oil Substances 0.000 description 2
- 235000019477 peppermint oil Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
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- 229950011392 sorbitan stearate Drugs 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- DTGKSKDOIYIVQL-NQMVMOMDSA-N (+)-Borneol Natural products C1C[C@]2(C)[C@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-NQMVMOMDSA-N 0.000 description 1
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
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- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
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- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 description 1
- JLHMJWHSBYZWJJ-UHFFFAOYSA-N 1,2-thiazole 1-oxide Chemical class O=S1C=CC=N1 JLHMJWHSBYZWJJ-UHFFFAOYSA-N 0.000 description 1
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- DHVLDKHFGIVEIP-UHFFFAOYSA-N 2-bromo-2-(bromomethyl)pentanedinitrile Chemical compound BrCC(Br)(C#N)CCC#N DHVLDKHFGIVEIP-UHFFFAOYSA-N 0.000 description 1
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- UBVSIAHUTXHQTD-UHFFFAOYSA-N 2-n-(4-bromophenyl)-1,3,5-triazine-2,4-diamine Chemical compound NC1=NC=NC(NC=2C=CC(Br)=CC=2)=N1 UBVSIAHUTXHQTD-UHFFFAOYSA-N 0.000 description 1
- BGRXBNZMPMGLQI-UHFFFAOYSA-N 2-octyldodecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC BGRXBNZMPMGLQI-UHFFFAOYSA-N 0.000 description 1
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- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
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Abstract
Description
本発明は、乳化組成物に関する。 The present invention relates to emulsifying compositions.
従来、手指消毒剤として用いられる乳化組成物が知られている。
特許文献１は、エタノール、油剤、ポリアクリレートクロスポリマー－６、及び（アクリロイルジメチルタウリンアンモニウム／ビニルピロリドン）コポリマーを含有する皮膚外用剤組成物について記載している。手指の消毒、殺菌、殺ウイルス、又は洗浄に用いることを記載している。
Emulsified compositions used as hand sanitizers are conventionally known.
Patent Document 1 describes an external skin preparation composition containing ethanol, an oil, polyacrylate crosspolymer-6, and (ammonium acryloyldimethyltaurate/vinylpyrrolidone) copolymer. It states that it is used for disinfecting, sterilizing, killing viruses, or cleaning hands and fingers.
ところで、ウイルスには、脂質膜を有するエンベロープウイルスと、脂質膜を有さないノンエンベロープウイルスとが存在することが知られている。エンベロープウイルスには、アルコールによる消毒が有効であることが知られている。近年、ノンエンベロープウイルスに対する消毒効果を高めるために、組成物のｐＨを酸性に調整する試みがなされている。しかし、乳化組成物の場合ではｐＨを酸性に調整すると、乳化安定性が低下することによって、経時的に乳化粒子が沈降しやすくなる虞があった。 By the way, it is known that viruses include enveloped viruses that have a lipid membrane and non-enveloped viruses that do not have a lipid membrane. Alcohol disinfection is known to be effective against enveloped viruses. In recent years, attempts have been made to adjust the pH of compositions to acidic in order to enhance the disinfecting effect against non-enveloped viruses. However, in the case of an emulsified composition, when the pH is adjusted to be acidic, there is a risk that the emulsion stability will be lowered and the emulsified particles will tend to settle over time.
上記課題を解決する乳化組成物の各態様を記載する。
態様１の乳化組成物は、エタノールと、油剤と、界面活性剤と、ヒドロキシプロピル基を有するセルロース系増粘剤と、ヒアルロン酸ナトリウムとを含有し、ｐＨが２.０以上４．５以下である。
Each aspect of the emulsified composition that solves the above problems will be described.
The emulsified composition of aspect 1 contains ethanol, an oil agent, a surfactant, a cellulose thickener having a hydroxypropyl group, and sodium hyaluronate, and has a pH of 2.0 or more and 4.5 or less. be.
態様２の乳化組成物は、態様１の乳化組成物において、前記ヒアルロン酸ナトリウムの含有量が、０．０１質量％以上０．５質量％以下である。
態様３の乳化組成物は、態様１又は２の乳化組成物において、前記界面活性剤が、平均酸化エチレン付加モル数が３０以上５０以下のポリオキシエチレン硬化ヒマシ油を含有する。
In the emulsified composition of Aspect 2, the content of the sodium hyaluronate in the emulsified composition of Aspect 1 is 0.01% by mass or more and 0.5% by mass or less.
In the emulsified composition of Aspect 3, in the emulsified composition of Aspect 1 or 2, the surfactant contains polyoxyethylene hydrogenated castor oil having an average number of added moles of ethylene oxide of 30 or more and 50 or less.
態様４の記乳化組成物は、態様１～態様３のいずれか一態様に記載の乳化組成物において、前記エタノールの含有量が、４０質量％以上８０質量％以下である。
態様５の乳化組成物は、態様１～態様４のいずれか一態様に記載の乳化組成物において、前記油剤が、植物油を含有する。
The emulsified composition according to aspect 4 is the emulsified composition according to any one of aspects 1 to 3, in which the content of the ethanol is 40% by mass or more and 80% by mass or less.
The emulsified composition according to aspect 5 is the emulsified composition according to any one of aspects 1 to 4, wherein the oil agent contains a vegetable oil.
本発明の乳化組成物によると、ｐＨが２.０以上４．５以下に調整された状態において乳化安定性を向上させることができる。 According to the emulsion composition of the present invention, emulsion stability can be improved in a state where the pH is adjusted to 2.0 or more and 4.5 or less.
本発明に係る乳化組成物を具体化した実施形態について説明する。
乳化組成物は、エタノールと、油剤と、界面活性剤と、ヒドロキシプロピル基を有するセルロース系増粘剤と、ヒアルロン酸ナトリウムとを含有し、ｐＨが２.０以上４．５以下である。
Embodiments embodying the emulsified composition according to the present invention will be described.
The emulsified composition contains ethanol, an oil agent, a surfactant, a cellulose thickener having a hydroxypropyl group, and sodium hyaluronate, and has a pH of 2.0 or more and 4.5 or less.
乳化組成物が、ヒアルロン酸ナトリウムを含有することにより、ｐＨが２.０以上４．５以下の酸性に調整された状態において乳化安定性を向上させることができる。
以下、乳化組成物を構成する各成分について説明する。
When the emulsion composition contains sodium hyaluronate, the emulsion stability can be improved in a state where the pH is adjusted to be acidic at 2.0 or more and 4.5 or less.
Each component constituting the emulsified composition will be explained below.
＜エタノール＞
エタノールとしては、特に制限されず、乳化組成物に配合される公知のエタノールを用いることができる。乳化組成物がエタノールを含有することにより、エタノールが有する手指の消毒、殺菌、殺ウイルス等の作用（以下、まとめて消毒効果ともいう。）を発現させることができる。
<Ethanol>
The ethanol is not particularly limited, and any known ethanol that is blended into emulsion compositions can be used. By containing ethanol in the emulsified composition, the effects of ethanol, such as disinfecting hands, sterilizing, and killing viruses (hereinafter also collectively referred to as disinfecting effects), can be exerted.
エタノールの含有量は、特に制限されないが、４０質量％以上であることが好ましく、４５質量％以上であることがより好ましく、４９質量％以上であることがさらに好ましい。また、８０質量％以下であることが好ましく、７５質量％以下であることがより好ましく、７０質量％以下であることがさらに好ましい。 The content of ethanol is not particularly limited, but is preferably 40% by mass or more, more preferably 45% by mass or more, and even more preferably 49% by mass or more. Further, it is preferably 80% by mass or less, more preferably 75% by mass or less, and even more preferably 70% by mass or less.
エタノールの含有量が上記数値範囲であると、エタノールによる消毒効果を好適に発現させつつ、乳化状態を維持しやすくなる。
＜油剤＞
油剤としては、特に制限されず、乳化組成物に配合される公知の油剤を用いることができる。乳化組成物が油剤を含有することにより、乳化組成物を使用した際に、手指に対して潤いを付与することができる。そのため、手指のかさつきや肌荒れを防ぐことができる。また、油剤を含有すると、乳化組成物が粘性を有した状態になりやすいため、使用感を向上させることができる。
When the content of ethanol is within the above numerical range, it becomes easier to maintain the emulsified state while suitably expressing the disinfecting effect of ethanol.
<Oil agent>
The oil agent is not particularly limited, and any known oil agent that is blended into an emulsion composition can be used. When the emulsified composition contains an oil agent, it is possible to moisturize hands and fingers when the emulsified composition is used. Therefore, it is possible to prevent dryness and rough skin of the fingers. Moreover, when an oil agent is contained, the emulsified composition tends to become viscous, so that the usability can be improved.
油剤としては、例えば天然動植物油脂、蝋、高級アルコール、高級脂肪酸、高級脂肪族炭化水素、合成エステル油、シリコーン誘導体等が挙げられる。
天然動植物油脂の具体例としては、例えばオリーブ油、ミンク油、ヒマシ油、パーム油、牛脂、月見草油、ヤシ油、ヒマシ油、カカオ油、マカデミアナッツ油、ホホバ油等が挙げられる。これらの中でも、オリーブ油、ヒマシ油、パーム油、月見草油、ヤシ油、ヒマシ油、カカオ油、マカデミアナッツ油等の植物油は、肌になじみやすいとともに、潤いを守りやすいため好ましい。
Examples of the oil agent include natural animal and vegetable oils, waxes, higher alcohols, higher fatty acids, higher aliphatic hydrocarbons, synthetic ester oils, silicone derivatives, and the like.
Specific examples of natural animal and vegetable oils include olive oil, mink oil, castor oil, palm oil, beef tallow, evening primrose oil, coconut oil, castor oil, cacao oil, macadamia nut oil, jojoba oil, and the like. Among these, vegetable oils such as olive oil, castor oil, palm oil, evening primrose oil, coconut oil, castor oil, cacao oil, and macadamia nut oil are preferred because they are easily absorbed by the skin and easily retain moisture.
蝋の具体例としては、例えばミツロウ、ラノリン、カルナウバロウ、キャンデリラロウ等が挙げられる。
高級アルコールの具体例としては、例えばラウリルアルコール、ステアリルアルコール、セチルアルコール、オレイルアルコール等が挙げられる。
Specific examples of wax include beeswax, lanolin, carnauba wax, candelilla wax, and the like.
Specific examples of higher alcohols include lauryl alcohol, stearyl alcohol, cetyl alcohol, and oleyl alcohol.
高級脂肪酸の具体例としては、例えばラウリン酸、パルミチン酸、ステアリン酸、オレイン酸、ベヘニン酸、ラノリン脂肪酸等が挙げられる。
高級脂肪族炭化水素の具体例としては、例えば流動パラフィン、固形パラフィン、スクワラン、ワセリン、セレシン、マイクロクリスタリンワックス等が挙げられる。
Specific examples of higher fatty acids include lauric acid, palmitic acid, stearic acid, oleic acid, behenic acid, and lanolin fatty acids.
Specific examples of higher aliphatic hydrocarbons include liquid paraffin, solid paraffin, squalane, vaseline, ceresin, and microcrystalline wax.
合成エステル油の具体例としては、例えばブチルステアレート、ヘキシルラウレート、ジイソプロピルアジペート、ジイソプロピルセバケート、ミリスチン酸オクチルドデシル、イソプロピルミリステート、イソプロピルパルミテートイソプロピルミリステート、セチルイソオクタノエート、ジカプリン酸ネオペンチルグリコール等が挙げられる。 Specific examples of synthetic ester oils include butyl stearate, hexyl laurate, diisopropyl adipate, diisopropyl sebacate, octyldodecyl myristate, isopropyl myristate, isopropyl palmitate isopropyl myristate, cetyl isooctanoate, neo dicaprate. Examples include pentyl glycol.
シリコーン誘導体の具体例としては、例えばメチルシリコーン、メチルフェニルシリコーン等のシリコーン油が挙げられる。
上記の油剤は、一種を単独で使用してもよく、二種以上を組み合わせて使用してもよい。
Specific examples of silicone derivatives include silicone oils such as methyl silicone and methylphenyl silicone.
The above oil agents may be used alone or in combination of two or more.
油剤の含有量は、特に制限されないが、０．１質量％以上であることが好ましく、０．５質量％以上であることがより好ましく、１.０質量％以上であることがさらに好ましい。また、７.０質量％以下であることが好ましく、５.０質量％以下であることがより好ましく、３.０質量％以下であることがさらに好ましい。 The content of the oil agent is not particularly limited, but is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and even more preferably 1.0% by mass or more. Further, it is preferably 7.0% by mass or less, more preferably 5.0% by mass or less, and even more preferably 3.0% by mass or less.
油剤の含有量が上記数値範囲であると、乳化組成物の乳化状態を維持しやすくなる。また、油剤の配合量が３.０質量％以下であると使用感がより向上しやすくなる。
＜界面活性剤＞
界面活性剤の具体例としては、例えば非イオン性界面活性剤が挙げられる。
When the content of the oil agent is within the above numerical range, it becomes easier to maintain the emulsified state of the emulsified composition. In addition, when the amount of the oil agent is 3.0% by mass or less, the usability is more likely to be improved.
<Surfactant>
Specific examples of surfactants include nonionic surfactants.
（非イオン性界面活性剤）
非イオン性界面活性剤の具体例としては、例えばショ糖脂肪酸エステル、マルトース脂肪酸エステル等の糖脂肪酸エステル、マルチトール脂肪酸エステル等の糖アルコール脂肪酸エステル、ステアリン酸ソルビタン、モノラウリン酸ソルビタン等のソルビタン脂肪酸エステル、ラウリン酸ポリオキシエチレンソルビタン（ポリソルベート２０ともいう。）、ステアリン酸ポリオキシエチレンソルビタン（ポリソルベート６０ともいう。）、オレイン酸ポリオキシエチレンソルビタン（ポリソルベート８０ともいう。）等のポリオキシエチレンソルビタン脂肪酸エステル、ラウリン酸ジエタノールアミド等の脂肪酸アルカノールアミド、ポリオキシエチレンステアリルエーテル、ポリオキシエチレンオレイルエーテル等のポリオキシエチレンアルキルエーテル、モノオレイン酸ポリエチレングリコール、モノラウリン酸ポリエチレングリコール等のポリエチレングリコール脂肪酸エステル、ラウリルグリコシド、デシルグリコシド等のアルキルグリコシド、ポリグリセリン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレン脂肪酸エステル、アルキルグルコシド類、ポリオキシエチレン硬化ヒマシ油（酸化エチレンの平均付加モル数が１０、２０、３０、４０、５０、６０のもの）、グリセリン脂肪酸エステル、ポリオキシエチレンプロピレンブロックコポリマー等が挙げられる。
(Nonionic surfactant)
Specific examples of nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters and maltose fatty acid esters, sugar alcohol fatty acid esters such as maltitol fatty acid esters, and sorbitan fatty acid esters such as sorbitan stearate and sorbitan monolaurate. , polyoxyethylene sorbitan sorbitan laurate (also referred to as polysorbate 20), polyoxyethylene sorbitan stearate (also referred to as polysorbate 60), polyoxyethylene sorbitan oleate (also referred to as polysorbate 80), and other polyoxyethylene sorbitan fatty acid esters. , fatty acid alkanolamides such as lauric acid diethanolamide, polyoxyethylene alkyl ethers such as polyoxyethylene stearyl ether and polyoxyethylene oleyl ether, polyethylene glycol fatty acid esters such as polyethylene glycol monooleate and polyethylene glycol monolaurate, lauryl glycoside, Alkyl glycosides such as decyl glycoside, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene fatty acid esters, alkyl glucosides, polyoxyethylene hydrogenated castor oil (average number of added moles of ethylene oxide is 10, 20, 30, 40, 50, 60), glycerin fatty acid ester, polyoxyethylene propylene block copolymer, and the like.
上記の界面活性剤は、一種を単独で使用してもよく、二種以上を組み合わせて使用してもよい。これらの中でも、界面活性剤は、平均酸化エチレン付加モル数が３０以上５０以下のポリオキシエチレン硬化ヒマシ油を含有することが好ましい。 The above surfactants may be used alone or in combination of two or more. Among these, the surfactant preferably contains polyoxyethylene hydrogenated castor oil having an average number of added moles of ethylene oxide of 30 or more and 50 or less.
平均酸化エチレン付加モル数が３０以上５０以下のポリオキシエチレン硬化ヒマシ油を含有すると、乳化状態を維持しやすくなる。
界面活性剤の含有量は、特に制限されないが、０．０５質量％以上であることが好ましく、０．１質量％以上であることがより好ましく、０．３質量％以上であることがさらに好ましい。また、５.０質量％以下であることが好ましく、３.０質量％以下であることがより好ましく、２.０質量％以下であることがさらに好ましい。
When polyoxyethylene hydrogenated castor oil having an average number of added moles of ethylene oxide of 30 or more and 50 or less is contained, it becomes easier to maintain an emulsified state.
The content of the surfactant is not particularly limited, but is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, and even more preferably 0.3% by mass or more. . Further, it is preferably 5.0% by mass or less, more preferably 3.0% by mass or less, and even more preferably 2.0% by mass or less.
界面活性剤の含有量が上記数値範囲であることにより、乳化状態を維持しやすくなる。
＜ヒドロキシプロピル基を有するセルロース系増粘剤＞
ヒドロキシプロピル基を有するセルロース系増粘剤としては、特に制限されず、ヒドロキシプロピル基を有する公知のセルロース系増粘剤を用いることができる。
When the content of the surfactant is within the above numerical range, it becomes easier to maintain the emulsified state.
<Cellulose thickener with hydroxypropyl group>
The cellulose thickener having a hydroxypropyl group is not particularly limited, and any known cellulose thickener having a hydroxypropyl group can be used.
ヒドロキシプロピル基を有するセルロース系増粘剤の具体例としては、例えばヒドロキシプロピルセルロース（以下、ＨＰＣともいう。）、ヒドロキシプロピルメチルセルロース（以下、ＨＰＭＣともいう。）等が挙げられる。 Specific examples of cellulose-based thickeners having hydroxypropyl groups include hydroxypropylcellulose (hereinafter also referred to as HPC), hydroxypropylmethylcellulose (hereinafter also referred to as HPMC), and the like.
ＨＰＭＣは、平均分子量が２０００以上であることが好ましく、３０００以上であることがより好ましい。また、２００００以下であることが好ましく、１５０００以下であることがより好ましい。 The average molecular weight of HPMC is preferably 2000 or more, more preferably 3000 or more. Further, it is preferably 20,000 or less, more preferably 15,000 or less.
ＨＰＭＣの平均分子量が上記数値範囲であることにより、ｐＨが２.０以上４．５以下に調整された状態において乳化状態をより好適に維持することができる。
ヒドロキシプロピル基を有するセルロース系増粘剤は、長鎖のアルキル基を有さないことが好ましい。長鎖のアルキル基は、炭素数が１８以上のアルキル基を意味するものとする。具体的には、ステアリル基、オレイル基等が挙げられる。長鎖のアルキル基を有さないことにより、乳化組成物の乳化状態を維持しやすくなる。
When the average molecular weight of HPMC is within the above numerical range, the emulsified state can be maintained more suitably in a state where the pH is adjusted to 2.0 or more and 4.5 or less.
The cellulose thickener having a hydroxypropyl group preferably does not have a long chain alkyl group. A long chain alkyl group shall mean an alkyl group having 18 or more carbon atoms. Specific examples include stearyl group and oleyl group. By not having a long-chain alkyl group, it becomes easier to maintain the emulsified state of the emulsified composition.
ヒドロキシプロピル基を有するセルロース系増粘剤の含有量は、特に制限されないが、０．５質量％以上であることが好ましく、１.０質量％以上であることがより好ましい。また、５.０質量％以下であることが好ましく、３.０質量％以下であることがより好ましい。 The content of the cellulose thickener having a hydroxypropyl group is not particularly limited, but is preferably 0.5% by mass or more, more preferably 1.0% by mass or more. Moreover, it is preferably 5.0% by mass or less, and more preferably 3.0% by mass or less.
ヒドロキシプロピル基を有するセルロース系増粘剤の含有量が上記数値範囲であることにより、ｐＨが２.０以上４．５以下に調整された状態において乳化状態をより好適に維持することができる。 When the content of the cellulose thickener having a hydroxypropyl group is within the above numerical range, an emulsified state can be maintained more suitably in a state where the pH is adjusted to 2.0 or more and 4.5 or less.
＜ヒアルロン酸ナトリウム＞
ヒアルロン酸ナトリウムとしては、特に制限されず、公知のヒアルロン酸ナトリウムを用いることができる。
<Sodium hyaluronate>
The sodium hyaluronate is not particularly limited, and known sodium hyaluronate can be used.
ヒアルロン酸ナトリウムの含有量は、特に制限されないが、０．０１質量％以上であることが好ましく、０．０２質量％以上であることがより好ましい。また、０．５質量％以下であることが好ましく、０．１質量％以下であることがより好ましい。 The content of sodium hyaluronate is not particularly limited, but is preferably 0.01% by mass or more, more preferably 0.02% by mass or more. Moreover, it is preferably 0.5% by mass or less, and more preferably 0.1% by mass or less.
ヒアルロン酸ナトリウムの含有量が上記数値範囲であることにより、ｐＨが２.０以上４．５以下に調整された状態において乳化安定性をより向上させることができる。
＜その他成分＞
乳化組成物は、適用目的、形態、用途等に応じて、前述した成分以外のその他成分、例えば、殺菌剤、抗菌剤、湿潤剤、ヒドロキシプロピル基を有するセルロース系増粘剤以外の増粘剤、安定化剤、防腐剤、ｐＨ調整剤、酸化防止剤、香料、着色剤、溶媒等を配合してもよい。これら各成分は、乳化組成物に配合される公知のものを使用することができる。これらの成分は、それぞれ一種を単独で使用してもよく、二種以上を組み合わせて使用してもよい。
When the content of sodium hyaluronate is within the above numerical range, emulsion stability can be further improved in a state where the pH is adjusted to 2.0 or more and 4.5 or less.
<Other ingredients>
The emulsified composition may contain other ingredients other than the above-mentioned ingredients, such as bactericidal agents, antibacterial agents, wetting agents, and thickeners other than cellulose thickeners having hydroxypropyl groups, depending on the application purpose, form, use, etc. , stabilizers, preservatives, pH adjusters, antioxidants, fragrances, colorants, solvents, etc. may be added. As each of these components, known components that are incorporated into emulsified compositions can be used. These components may be used alone or in combination of two or more.
殺菌剤の具体例としては、例えばセチルピリジニウム塩化物水和物、ヒノキチオール等が挙げられる。
抗菌剤の具体例としては、例えばパラベン類、安息香酸ナトリウム、トリクロサン、塩酸クロルヘキシジン、グルコン酸クロルヘキシジン、ミノサイクリン塩酸塩、イソプロピルメチルフェノール、塩化ベンザルコニウム、塩化ベンゼトニウム等が挙げられる。なお、殺菌剤と抗菌剤は、有効成分ともいうものとする。
Specific examples of disinfectants include cetylpyridinium chloride hydrate, hinokitiol, and the like.
Specific examples of antibacterial agents include parabens, sodium benzoate, triclosan, chlorhexidine hydrochloride, chlorhexidine gluconate, minocycline hydrochloride, isopropylmethylphenol, benzalkonium chloride, benzethonium chloride, and the like. Note that bactericidal agents and antibacterial agents are also referred to as active ingredients.
湿潤剤の具体例としては、例えば、プロピレングリコール、グリセリン、ソルビトール、ポリエチレングリコール、１，３－ブチレングリコール等が挙げられる。
ヒドロキシプロピル基を有するセルロース系増粘剤以外の増粘剤の具体例としては、例えばポリアクリル酸ナトリウム、ポリエチレングリコール、カラギーナン、カルボキシメチルセルロースナトリウム、アルギン酸ナトリウム、キサンタンガム、ヒドロキシエチルセルロース、結晶セルロース、メチルセルロース、アルギン酸プロピレングリコールエステル等が挙げられる。増粘剤は、粘結剤ともいう。
Specific examples of wetting agents include propylene glycol, glycerin, sorbitol, polyethylene glycol, 1,3-butylene glycol, and the like.
Specific examples of thickeners other than cellulose thickeners having hydroxypropyl groups include sodium polyacrylate, polyethylene glycol, carrageenan, sodium carboxymethyl cellulose, sodium alginate, xanthan gum, hydroxyethyl cellulose, crystalline cellulose, methyl cellulose, and alginic acid. Examples include propylene glycol ester. Thickeners are also called binders.
安定化剤の具体例としては、例えばエデト酸ナトリウム、チオ硫酸ナトリウム、亜硫酸ナトリウム、乳酸カルシウム、ラノリン、トリアセチン、ヒマシ油、硫酸マグネシウム等が挙げられる。 Specific examples of the stabilizer include sodium edetate, sodium thiosulfate, sodium sulfite, calcium lactate, lanolin, triacetin, castor oil, magnesium sulfate, and the like.
防腐剤の具体例としては、例えば１，２－ジブロモ－２、４－ジシアノブタン、感光素、イソチアゾロン誘導体、ヒダントイン誘導体等が挙げられる。
ｐＨ調整剤の具体例としては、例えばクエン酸、リン酸、リンゴ酸、ピロリン酸、乳酸、酒石酸、グリセロリン酸、グルコン酸、酢酸、硝酸、又はこれらの化学的に可能な塩、水酸化ナトリウム等が挙げられる。
Specific examples of preservatives include 1,2-dibromo-2,4-dicyanobutane, photosensitizers, isothiazolone derivatives, hydantoin derivatives, and the like.
Specific examples of pH adjusters include citric acid, phosphoric acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphoric acid, gluconic acid, acetic acid, nitric acid, or chemically possible salts thereof, sodium hydroxide, etc. can be mentioned.
酸化防止剤の具体例としては、例えばトコフェロール類、ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、没食子酸エステル類等が挙げられる。
香料は、天然香料や合成香料であってもよい。また、単品香料や調合香料であってもよい。
Specific examples of antioxidants include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters, and the like.
The fragrance may be a natural fragrance or a synthetic fragrance. Further, it may be a single fragrance or a mixed fragrance.
香料の具体例としては、例えばｌ－メントール、ｄ－カルボン、アネトール、オイゲノール、サリチル酸メチル、リモネン、オシメン、ｎ－デシルアルコール、シトロネロール、α－テルピネオール、メチルアセテート、シトロネリルアセテート、メチルオイゲノール、シネオール、リナロール、エチルリナロール、チモール、スペアミント油、ペパーミント油、レモン油、オレンジ油、セージ油、ローズマリー油、シソ油、冬緑油、丁子油、ユーカリ油、ピメント油、ｄ－カンフル、ｄ－ボルネオール、ウイキョウ油、ケイヒ油、シンナムアルデヒド、ハッカ油、バニリン等が挙げられる。 Specific examples of fragrances include l-menthol, d-carvone, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronellol, α-terpineol, methyl acetate, citronellyl acetate, methyl eugenol, cineol, Linalool, ethyl linalool, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil, pimento oil, d-camphor, d-borneol, Examples include fennel oil, cinnamon oil, cinnamaldehyde, peppermint oil, and vanillin.
着色剤の具体例としては、例えば緑色１号、緑色３号、青色１号、黄色４号、黄色５号、赤色１０２号、赤色３号等の法定色素、銅クロロフィンナトリウム、酸化チタン等が挙げられる。 Specific examples of colorants include legal pigments such as Green No. 1, Green No. 3, Blue No. 1, Yellow No. 4, Yellow No. 5, Red No. 102, Red No. 3, copper chlorofin sodium, titanium oxide, etc. Can be mentioned.
溶媒の具体例としては、例えば水、エタノール以外のアルコール等が挙げられる。
＜乳化組成物の適用形態、剤形、用途＞
乳化組成物の適用形態は、特に限定されず、例えば医薬品、指定医薬部外品、医薬部外品、化粧品として使用することができる。
Specific examples of the solvent include water, alcohols other than ethanol, and the like.
<Application form, dosage form, and use of emulsified composition>
The application form of the emulsified composition is not particularly limited, and can be used, for example, as a pharmaceutical, a designated quasi-drug, a quasi-drug, or a cosmetic.
乳化組成物の剤形は、特に制限されず、例えば乳液、スプレー剤、ペースト剤、軟膏剤、ジェル、ローション等として使用することができる。
乳化組成物の用途としては、特に制限されず、例えば手指消毒剤、アルコール消毒剤、皮膚外用剤等が挙げられる。
The dosage form of the emulsified composition is not particularly limited, and can be used as, for example, an emulsion, a spray, a paste, an ointment, a gel, a lotion, and the like.
Applications of the emulsified composition are not particularly limited, and include, for example, hand disinfectants, alcohol disinfectants, skin external preparations, and the like.
乳化組成物のｐＨは、２．４以上であることが好ましい。また、４．１以下であることが好ましい。
＜作用及び効果＞
本実施形態の乳化組成物の作用について説明する。
The pH of the emulsified composition is preferably 2.4 or higher. Moreover, it is preferable that it is 4.1 or less.
<Action and effect>
The effect of the emulsified composition of this embodiment will be explained.
乳化組成物を液中で安定に分散させるためには、外相の粘度を大きくすることが効果的である。ヒドロキシプロピル基を有するセルロース系増粘剤は、水素イオンの影響を受けにくいノニオン性のセルロースエーテルで、ヒドロキシ基を部分的にヒドロキシプロピル基で置換することで水や混合有機溶媒に溶けやすくなっている。そのため、水素イオン濃度の高いｐＨ２．０以上４．５以下の条件下においても、ヒドロキシプロピル基を有するセルロース系増粘剤を含有することにより、乳化状態を維持可能な粘度を付与できる。 In order to stably disperse the emulsified composition in a liquid, it is effective to increase the viscosity of the external phase. Cellulose-based thickeners with hydroxypropyl groups are nonionic cellulose ethers that are not easily affected by hydrogen ions, and by partially substituting hydroxyl groups with hydroxypropyl groups, they become more soluble in water and mixed organic solvents. There is. Therefore, by containing a cellulose-based thickener having a hydroxypropyl group, a viscosity that can maintain an emulsified state can be imparted even under conditions of pH 2.0 to 4.5, where the hydrogen ion concentration is high.
また、酸性ムコ多糖のヒアルロン酸ナトリウムが乳化粒子表面の電荷的反発を生み出すことで乳化安定性を向上させ、経時的な乳化粒子の沈降を抑制することができる。
本実施形態の乳化組成物の効果について説明する。
In addition, sodium hyaluronate, which is an acidic mucopolysaccharide, creates charge repulsion on the surface of emulsified particles, thereby improving emulsion stability and suppressing sedimentation of emulsified particles over time.
The effects of the emulsified composition of this embodiment will be explained.
（１）エタノールと、油剤と、界面活性剤と、ヒドロキシプロピル基を有するセルロース系増粘剤と、ヒアルロン酸ナトリウムとを含有し、ｐＨが２．０以上４．５以下である。 (1) Contains ethanol, an oil agent, a surfactant, a cellulose thickener having a hydroxypropyl group, and sodium hyaluronate, and has a pH of 2.0 or more and 4.5 or less.
ヒアルロン酸ナトリウムを含有することによって、乳化安定性を向上させることができる。したがって、ｐＨが２．０以上４．５以下に調整された状態において経時的に乳化粒子が沈降しやすくなることを抑制することができる。また、ｐＨが２．０以上４．５以下に調整されていることによって、ノンエンベロープウイルスに対する消毒効果を高めることができる。 By containing sodium hyaluronate, emulsion stability can be improved. Therefore, it is possible to suppress the tendency of emulsified particles to settle over time in a state where the pH is adjusted to 2.0 or more and 4.5 or less. Moreover, by adjusting the pH to 2.0 or more and 4.5 or less, the disinfecting effect against non-enveloped viruses can be enhanced.
（２）ヒアルロン酸ナトリウムの含有量が、０．０１質量％以上０．５質量％以下である。したがって、ｐＨが２．０以上４．５以下に調整された状態において乳化安定性をより向上させることができる。 (2) The content of sodium hyaluronate is 0.01% by mass or more and 0.5% by mass or less. Therefore, emulsion stability can be further improved in a state where the pH is adjusted to 2.0 or more and 4.5 or less.
（３）界面活性剤が、平均酸化エチレン付加モル数が３０以上５０以下のポリオキシエチレン硬化ヒマシ油を含有する。したがって、乳化状態を維持しやすくなる。
（４）エタノールの含有量が、４０質量％以上８０質量％以下である。したがって、ノンエンベロープウイルスに対する消毒効果に加えて、エンベロープウイルスに対する消毒効果を好適に発現させることができる。
(3) The surfactant contains polyoxyethylene hydrogenated castor oil having an average number of added moles of ethylene oxide of 30 or more and 50 or less. Therefore, it becomes easier to maintain the emulsified state.
(4) The content of ethanol is 40% by mass or more and 80% by mass or less. Therefore, in addition to the disinfecting effect on non-enveloped viruses, the disinfecting effect on enveloped viruses can be suitably expressed.
（５）油剤が、植物油を含有する。したがって、乳化組成物が肌になじみやすくなるとともに、潤いを守りやすくなる。 (5) The oil agent contains vegetable oil. Therefore, the emulsified composition becomes more easily absorbed into the skin, and it becomes easier to protect the skin from moisture.
以下、本発明の構成、及び効果をより具体的にするため、実施例等を挙げるが、本発明がこれらの実施例に限定されるというものではない。
表１に示す実施例１、２及び比較例１、２の乳化組成物を常法に従って各成分を混合することによって製造した。具体的には、油剤と界面活性剤とを先に混合する。これとは別に、エタノール、水、増粘剤、ヒアルロン酸ナトリウム、ｐＨ調整剤、抗菌剤を混合する。油剤と界面活性剤の混合液と、エタノール、水、増粘剤、ヒアルロン酸ナトリウム、ｐＨ調整剤、抗菌剤の混合液とを混合する。得られた混合液を撹拌することによって乳化組成物を製造した。なお、上記の製造方法は、適宜順番を入れかえて行ってもよい。
Examples will be given below to make the structure and effects of the present invention more concrete, but the present invention is not limited to these Examples.
The emulsified compositions of Examples 1 and 2 and Comparative Examples 1 and 2 shown in Table 1 were produced by mixing each component according to a conventional method. Specifically, the oil agent and the surfactant are mixed first. Separately, ethanol, water, thickener, sodium hyaluronate, pH adjuster, and antibacterial agent are mixed. A mixture of oil and surfactant is mixed with a mixture of ethanol, water, thickener, sodium hyaluronate, pH adjuster, and antibacterial agent. An emulsion composition was manufactured by stirring the obtained liquid mixture. Note that the above manufacturing method may be performed by changing the order as appropriate.
なお、表１において、各成分の右側に記載した数字は、各成分の含有量（質量％）を意味し、合計で１００質量％となるように配合した。乳化組成物は、乳液の形態を有していた。 In addition, in Table 1, the numbers written on the right side of each component mean the content (mass%) of each component, which was blended so that the total was 100% by mass. The emulsified composition had the form of a milky lotion.
なお、表１において、ＰＯＥ硬化ヒマシ油４０は、酸化エチレンの平均付加モル数が４０のポリオキシエチレン硬化ヒマシ油を意味する。また、ＨＰＭＣ（分子量１００００）、及びＨＰＭＣ（分子量４０００）は、それぞれ平均分子量が１００００と４０００のヒドロキシプロピルメチルセルロースを意味する。 In Table 1, POE hydrogenated castor oil 40 means polyoxyethylene hydrogenated castor oil having an average number of added moles of ethylene oxide of 40. Furthermore, HPMC (molecular weight 10,000) and HPMC (molecular weight 4,000) mean hydroxypropyl methyl cellulose with average molecular weights of 10,000 and 4,000, respectively.
実施例１、２及び比較例１、２の乳化組成物について、ｐＨ、乳化状態、及び乳化安定性を評価した。ｐＨの測定には、公知のｐＨ測定器を用いた。乳化状態と乳化安定性の評価方法、及び評価結果について以下に示す。
The emulsion compositions of Examples 1 and 2 and Comparative Examples 1 and 2 were evaluated for pH, emulsion state, and emulsion stability. A known pH meter was used to measure the pH. The method for evaluating the emulsion state and emulsion stability, and the evaluation results are shown below.
（乳化状態の評価方法）
上記の製造方法によって製造した実施例１、２及び比較例１、２の乳化組成物について、製造直後から外観を目視で観察した。下記の評価基準で評価した。
(Evaluation method of emulsification state)
The appearance of the emulsion compositions of Examples 1 and 2 and Comparative Examples 1 and 2 produced by the above production method was visually observed immediately after production. Evaluation was made using the following evaluation criteria.
・乳化状態の評価基準
○（良好）：製造直後から凝集や沈殿が見られず、一週間経過後も良好な乳化状態が維持されていた場合
×（不可）：製造直後に凝集や沈殿が見られた場合、もしくは製造直後は凝集や沈殿が見られないものの、一週間以内に凝集や沈殿が生じた場合
（乳化安定性の評価方法）
上記の製造方法によって製造した実施例１、２及び比較例１、２の乳化組成物について、室温と４０℃の２種類の温度条件下で３カ月間放置した。３か月後の乳化組成物の外観を目視で観察した。下記の評価基準で評価した。
・Evaluation criteria for emulsification state ○ (Good): No aggregation or precipitation was observed immediately after production, and a good emulsification state was maintained even after one week. × (Unsatisfactory): Aggregation or precipitation was observed immediately after production. or if no aggregation or precipitation is observed immediately after production, but aggregation or precipitation occurs within one week (emulsion stability evaluation method)
The emulsified compositions of Examples 1 and 2 and Comparative Examples 1 and 2 produced by the above production method were left for 3 months under two temperature conditions: room temperature and 40°C. The appearance of the emulsified composition after 3 months was visually observed. Evaluation was made using the following evaluation criteria.
・乳化安定性評価基準
○（良好）：乳化粒子の沈降が見られず、良好な乳化状態が維持されていた場合
×（不可）：乳化粒子が沈降していた場合
（評価結果）
表１より、比較例１、２、実施例１、２の乳化組成物は、いずれも乳化状態は良好であった。しかし、比較例１、２の乳化組成物は、ヒアルロン酸ナトリウムを含有しておらず、室温と４０℃のいずれの条件においても、乳化安定性が劣ることが確認された。
・Emulsification stability evaluation criteria ○ (Good): No sedimentation of emulsified particles was observed and a good emulsified state was maintained × (Unsatisfactory): When emulsified particles were sedimented (Evaluation results)
From Table 1, the emulsified compositions of Comparative Examples 1 and 2 and Examples 1 and 2 had good emulsified states. However, the emulsion compositions of Comparative Examples 1 and 2 did not contain sodium hyaluronate, and it was confirmed that the emulsion stability was poor at both room temperature and 40°C.
これに対し、実施例１、２では、ヒアルロン酸ナトリウムを含有しているため、室温と４０℃のいずれの条件においても、乳化安定性が良好であった。そのため、ｐＨが２.０以上４．５以下に調整された状態において乳化安定性が向上していることが確認された。 On the other hand, in Examples 1 and 2, since sodium hyaluronate was contained, the emulsion stability was good both at room temperature and at 40°C. Therefore, it was confirmed that the emulsion stability was improved when the pH was adjusted to 2.0 or more and 4.5 or less.
Claims (5)
ｐＨが２.０以上４．５以下であることを特徴とする乳化組成物。 Contains ethanol, an oil agent, a surfactant, a cellulose thickener having a hydroxypropyl group, and sodium hyaluronate,
An emulsified composition having a pH of 2.0 or more and 4.5 or less.
The emulsified composition according to any one of claims 1 to 4, wherein the oil agent contains a vegetable oil.
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