JP2023178143A - Oral composition - Google Patents
Oral composition Download PDFInfo
- Publication number
- JP2023178143A JP2023178143A JP2022091233A JP2022091233A JP2023178143A JP 2023178143 A JP2023178143 A JP 2023178143A JP 2022091233 A JP2022091233 A JP 2022091233A JP 2022091233 A JP2022091233 A JP 2022091233A JP 2023178143 A JP2023178143 A JP 2023178143A
- Authority
- JP
- Japan
- Prior art keywords
- oral composition
- oral
- composition according
- oil
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 93
- 239000007788 liquid Substances 0.000 claims abstract description 29
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 11
- 210000000214 mouth Anatomy 0.000 claims description 39
- -1 ester compound Chemical class 0.000 claims description 30
- 239000007787 solid Substances 0.000 claims description 21
- 230000000694 effects Effects 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 12
- 239000004480 active ingredient Substances 0.000 claims description 11
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 235000003599 food sweetener Nutrition 0.000 claims description 6
- 239000003765 sweetening agent Substances 0.000 claims description 6
- 229910019142 PO4 Inorganic materials 0.000 claims description 5
- 238000004061 bleaching Methods 0.000 claims description 5
- 235000019410 glycyrrhizin Nutrition 0.000 claims description 5
- 229930195733 hydrocarbon Natural products 0.000 claims description 5
- 150000002430 hydrocarbons Chemical class 0.000 claims description 5
- 229920003169 water-soluble polymer Polymers 0.000 claims description 5
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 claims description 4
- 239000004215 Carbon black (E152) Substances 0.000 claims description 4
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 claims description 4
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 4
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 4
- 238000004042 decolorization Methods 0.000 claims description 4
- 229960003720 enoxolone Drugs 0.000 claims description 4
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 claims description 4
- 238000002844 melting Methods 0.000 claims description 4
- 230000008018 melting Effects 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 4
- 239000010452 phosphate Substances 0.000 claims description 4
- 229940088594 vitamin Drugs 0.000 claims description 3
- 235000013343 vitamin Nutrition 0.000 claims description 3
- 239000011782 vitamin Substances 0.000 claims description 3
- 229930003231 vitamin Natural products 0.000 claims description 3
- 235000011180 diphosphates Nutrition 0.000 claims description 2
- 125000005341 metaphosphate group Chemical group 0.000 claims description 2
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 2
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 claims description 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 208000006558 Dental Calculus Diseases 0.000 abstract description 3
- 206010006326 Breath odour Diseases 0.000 abstract description 2
- 102000004169 proteins and genes Human genes 0.000 abstract description 2
- 108090000623 proteins and genes Proteins 0.000 abstract description 2
- 208000002064 Dental Plaque Diseases 0.000 abstract 1
- 238000004040 coloring Methods 0.000 abstract 1
- 238000010186 staining Methods 0.000 abstract 1
- 239000003921 oil Substances 0.000 description 37
- 235000019198 oils Nutrition 0.000 description 37
- 239000011248 coating agent Substances 0.000 description 27
- 238000000576 coating method Methods 0.000 description 27
- 238000011156 evaluation Methods 0.000 description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 7
- 239000002202 Polyethylene glycol Substances 0.000 description 7
- 229920001223 polyethylene glycol Polymers 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000000551 dentifrice Substances 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 150000004665 fatty acids Chemical class 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 235000002639 sodium chloride Nutrition 0.000 description 5
- 239000008247 solid mixture Substances 0.000 description 5
- 239000001993 wax Substances 0.000 description 5
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 4
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 4
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 4
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 4
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- 235000010356 sorbitol Nutrition 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 241001122767 Theaceae Species 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 229960003237 betaine Drugs 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 235000019864 coconut oil Nutrition 0.000 description 3
- 239000003240 coconut oil Substances 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 235000021317 phosphate Nutrition 0.000 description 3
- 229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
- QYIXCDOBOSTCEI-QCYZZNICSA-N (5alpha)-cholestan-3beta-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-QCYZZNICSA-N 0.000 description 2
- ASKIVFGGGGIGKH-UHFFFAOYSA-N 2,3-dihydroxypropyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(O)CO ASKIVFGGGGIGKH-UHFFFAOYSA-N 0.000 description 2
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 2
- LEEDMQGKBNGPDN-UHFFFAOYSA-N 2-methylnonadecane Chemical compound CCCCCCCCCCCCCCCCCC(C)C LEEDMQGKBNGPDN-UHFFFAOYSA-N 0.000 description 2
- ZFGOPJASRDDARH-UHFFFAOYSA-N 3-[[10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl]oxy]-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthrene Chemical compound C12CCC3(C)C(C(C)CCCC(C)C)CCC3C2CC=C(C2)C1(C)CCC2OC1CC2=CCC3C4CCC(C(C)CCCC(C)C)C4(C)CCC3C2(C)CC1 ZFGOPJASRDDARH-UHFFFAOYSA-N 0.000 description 2
- PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 description 2
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 2
- AXCXHFKZHDEKTP-NSCUHMNNSA-N 4-methoxycinnamaldehyde Chemical compound COC1=CC=C(\C=C\C=O)C=C1 AXCXHFKZHDEKTP-NSCUHMNNSA-N 0.000 description 2
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 2
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 2
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- 239000004382 Amylase Substances 0.000 description 2
- 102000013142 Amylases Human genes 0.000 description 2
- 108010065511 Amylases Proteins 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
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- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical class C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 description 2
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- KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 description 2
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- 239000005313 bioactive glass Substances 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
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- 235000013477 citrulline Nutrition 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 229940108925 copper gluconate Drugs 0.000 description 2
- 229960003624 creatine Drugs 0.000 description 2
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- 230000002335 preservative effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 229940069949 propolis Drugs 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
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- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000004170 rice bran wax Substances 0.000 description 1
- 235000019384 rice bran wax Nutrition 0.000 description 1
- 239000010668 rosemary oil Substances 0.000 description 1
- 229940058206 rosemary oil Drugs 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 239000010670 sage oil Substances 0.000 description 1
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- 239000008299 semisolid dosage form Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
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- 238000000926 separation method Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
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- 235000015424 sodium Nutrition 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229940079841 sodium copper chlorophyllin Drugs 0.000 description 1
- 235000013758 sodium copper chlorophyllin Nutrition 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 229940073490 sodium glutamate Drugs 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- SLBXZQMMERXQAL-UHFFFAOYSA-M sodium;1-dodecoxy-4-hydroxy-1,4-dioxobutane-2-sulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O SLBXZQMMERXQAL-UHFFFAOYSA-M 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 229950011392 sorbitan stearate Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- XJPBRODHZKDRCB-UHFFFAOYSA-N trans-alpha-ocimene Natural products CC(=C)CCC=C(C)C=C XJPBRODHZKDRCB-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940118594 trimethylolpropane triisostearate Drugs 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は口腔用組成物等に関し、より詳細には液状油分を含有する口腔用組成物等に関する。 The present invention relates to oral compositions and the like, and more particularly to oral compositions containing liquid oil.
口腔内では、飲食物が歯面と接触し、また残留することを起因として、様々な口腔トラブルが発生している。食物残渣は口腔内細菌の代謝により、プラーク(歯垢)が歯面上で形成される原因となり、むし歯や歯周病といった口腔内疾患の発生、進行を促進している。また柑橘類、清涼飲料水などの酸性飲食物は、歯との接触により脱灰(酸蝕)を直接的に引き起こしている。さらに歯の着色汚れであるステインは、飲食物由来ポリフェノール等の着色成分が蓄積されることで形成され、歯の審美性を悪化させ、口まわりの清潔感、ひいては顔全体の印象を低下させる。 In the oral cavity, various oral problems occur due to food and drink coming into contact with tooth surfaces and remaining therein. Food residue causes plaque to form on tooth surfaces through the metabolism of oral bacteria, promoting the development and progression of oral diseases such as cavities and periodontal disease. In addition, acidic foods and drinks such as citrus fruits and soft drinks directly cause demineralization (acid erosion) when they come into contact with teeth. Furthermore, stains, which are discolored stains on teeth, are formed due to the accumulation of coloring components such as polyphenols derived from food and drink, which deteriorate the aesthetics of teeth, reduce the cleanliness around the mouth, and ultimately the impression of the entire face.
これらの口腔トラブルを予防するためには、歯面を被覆するなどして、飲食物と歯面とが接触している状態を極力減らすことが望ましい。歯面を被覆する技術としては、リン酸エステル又はポリマーによる歯面コーティング技術(特許文献1及び2)、茶抽出物による歯質強化技術(特許文献3)等が提案されている。 In order to prevent these oral problems, it is desirable to reduce the contact between food and drink and tooth surfaces as much as possible, such as by coating the tooth surfaces. As techniques for coating tooth surfaces, tooth surface coating techniques using phosphate esters or polymers (Patent Documents 1 and 2), tooth reinforcement techniques using tea extracts (Patent Document 3), and the like have been proposed.
しかしながら、上記特許文献1~3で提案される技術は、使用者にその歯面コーティング効果を満足に実感させることが難しく、使用実感の向上に課題があった。常に唾液で湿潤されている口腔内において、特許文献1~3をはじめとする従来の水系口腔用組成物では、使用による歯面コーティング実感を付与することは困難であった。 However, with the techniques proposed in Patent Documents 1 to 3 mentioned above, it is difficult to make the user feel the tooth surface coating effect satisfactorily, and there is a problem in improving the user experience. In the oral cavity, which is constantly moistened with saliva, it has been difficult for conventional water-based oral compositions such as those disclosed in Patent Documents 1 to 3 to provide the feeling of tooth surface coating when used.
本発明者らは鋭意検討を重ねた結果、液状油分及び界面活性剤を配合した油系組成物は、口腔内に油状基剤が分散し、口腔組織を被覆することで、高い歯面コーティング実感を示すことを見出した。 As a result of extensive research, the present inventors found that an oil-based composition containing a liquid oil and a surfactant disperses the oil base in the oral cavity and coats the oral tissues, resulting in a high level of tooth surface coating. We found that this shows that
また優れた歯面滞留性により、歯面コーティングによるプラーク、ステインの沈着防止、並びに歯牙表面からのカルシウムイオンの溶出防止をすることができる。さらに、本発明の口腔用組成物であれば、優れた口腔内(歯面、歯肉、粘膜、舌)滞留性をも有するため、組成物に含有される有効成分の口腔内滞留量を増加させることができる。 Furthermore, due to its excellent retention on tooth surfaces, it is possible to prevent the deposition of plaque and stains by coating tooth surfaces, and to prevent the elution of calcium ions from tooth surfaces. Furthermore, since the oral composition of the present invention has excellent retention properties in the oral cavity (tooth surfaces, gums, mucous membranes, tongue), it increases the amount of active ingredients contained in the composition retained in the oral cavity. be able to.
これにより歯質強化、殺菌、抗炎症、知覚過敏抑制、歯石形成抑制、コラーゲン分解抑制、収れん作用、血行促進、細胞賦活化、コラーゲン産生、組織修復、止血保湿作用を高めた口腔用組成物の提供が可能となる。 This results in an oral composition that strengthens tooth structure, sterilizes, anti-inflammatory, suppresses hypersensitivity, inhibits tartar formation, inhibits collagen decomposition, astringent action, promotes blood circulation, activates cells, produces collagen, repairs tissue, and enhances hemostasis and moisturizing effects. It becomes possible to provide.
加えて本発明の口腔用組成物であれば、高配合された液状油分、界面活性剤による高い洗浄効果も有するため、プラーク(歯垢)、ステイン(着色)、タンパク質汚れ、口臭、歯石を効果的に除去できる。 In addition, the oral composition of the present invention has a high cleaning effect due to the high content of liquid oil and surfactant, so it is effective against plaque, stains, protein stains, bad breath, and tartar. can be removed.
本発明は例えば以下の項に記載の主題を包含する。
項1.
(A)液状油分を30~95質量%、
(B)ノニオン界面活性剤を1種以上
を含有する口腔用組成物。
項2.
液状油分がエステル化合物である、項1記載の口腔用組成物。
項3.
液状油分が飽和脂肪酸エステル化合物である、項1又は2に記載の口腔用組成物。
項4.
ノニオン性界面活性剤の一種以上が、HLB値5~13である、項1~3のいずれか1項に記載の口腔用組成物。
項5.
更に、融点が50~120℃である固形油分を1~30質量%を含有する、項1~4のいずれか1項に記載の口腔用組成物。
項6.
固形油分が、炭化水素である項5記載の口腔用組成物。
項7.
更に、(C)口腔内に適用可能な清涼化剤及び/又は甘味剤を含有する、項1~6のいずれか1項に記載の口腔用組成物。
項8.
更に、縮合リン酸塩を含有し、縮合リン酸塩がピロリン酸塩、トリポリリン酸塩、及びメタリン酸塩からなる群より選ばれる1種以上である、項1~7のいずれか1項に記載の口腔用組成物。
項9.
更に、親油性有効成分を含有し、親油性有効成分がイソプロピルメチルフェノール、塩化セチルピリジニウム、グリチルリチン酸類、グリチルレチン酸、ビタミン類からなる群より選ばれる1種以上である、項1~8のいずれか1項に記載の口腔用組成物。
項10.
更に、歯牙硬組織の着色除去効果及び/又は漂白効果を有する水溶性高分子を一種以上含有する、項1~9のいずれか1項に記載の口腔用組成物。
項11.
項1~9のいずれか1項に記載の口腔用組成物と、電動歯ブラシを併用することによる歯のステインを除去する方法。
The present invention includes, for example, the subject matter described in the following sections.
Item 1.
(A) 30 to 95% by mass of liquid oil,
(B) An oral composition containing one or more nonionic surfactants.
Item 2.
Item 2. The oral composition according to item 1, wherein the liquid oil is an ester compound.
Item 3.
Item 3. The oral composition according to item 1 or 2, wherein the liquid oil is a saturated fatty acid ester compound.
Item 4.
Item 4. The oral composition according to any one of Items 1 to 3, wherein the one or more nonionic surfactants have an HLB value of 5 to 13.
Item 5.
Item 5. The oral composition according to any one of Items 1 to 4, further comprising 1 to 30% by mass of solid oil having a melting point of 50 to 120°C.
Item 6.
6. The oral composition according to item 5, wherein the solid oil is a hydrocarbon.
Section 7.
Item 7. The oral composition according to any one of Items 1 to 6, further comprising (C) a refreshing agent and/or sweetener that can be applied to the oral cavity.
Section 8.
Furthermore, it contains a condensed phosphate, and the condensed phosphate is one or more selected from the group consisting of pyrophosphate, tripolyphosphate, and metaphosphate, according to any one of Items 1 to 7. Oral composition.
Item 9.
Furthermore, any one of Items 1 to 8 contains a lipophilic active ingredient, and the lipophilic active ingredient is one or more selected from the group consisting of isopropylmethylphenol, cetylpyridinium chloride, glycyrrhizic acids, glycyrrhetinic acid, and vitamins. Oral composition according to item 1.
Item 10.
10. The oral cavity composition according to any one of Items 1 to 9, further comprising one or more water-soluble polymers having an effect of removing coloration and/or bleaching tooth hard tissue.
Item 11.
Item 10. A method for removing tooth stains by using the oral composition according to any one of Items 1 to 9 in combination with an electric toothbrush.
本発明の口腔用組成物は高い歯面コーティング実感を有するとともに、歯面コーティングによるプラーク、ステインの沈着予防、脱灰抑制効果、高い洗浄効果、さらには含有する有効成分の口腔内への滞留性をも高めることができる。 The oral composition of the present invention has a high tooth surface coating feeling, and the tooth surface coating prevents the deposition of plaque and stains, suppresses decalcification, has a high cleaning effect, and furthermore, the active ingredients contained therein retain in the oral cavity. can also be increased.
以下、本発明に包含される各実施形態について、さらに詳細に説明する。本発明は、口腔用組成物、当該組成物の製造方法等を好ましく包含するが、これらに限定されるわけではなく、本発明は本明細書に開示される全てを包含する。なお、以下、特に断らない限り、「%」は「質量%」を示す。 Hereinafter, each embodiment included in the present invention will be described in further detail. The present invention preferably includes an oral composition, a method for producing the composition, etc., but is not limited thereto, and the present invention includes everything disclosed herein. In addition, hereinafter, "%" indicates "mass %" unless otherwise specified.
液状油分としては、口腔内に適用可能であり、室温(25℃)において液状のものであれば特に限定されない。例えば、パルミチン酸2-エチルへキシル、ミリスチン酸イソプロピル、リノール酸エチル、パルミチン酸イソプロピル、オレイン酸オレイル、ミリスチン酸イソトリデシル、ミリスチン酸2-エチルへキシル、オレイン酸デシル、ミリスチン酸イソステアリル、ミリスチン酸オクチルドデシル、ステアリン酸2-エチルへキシル、ステアリン酸2-へキシルデシル、パルミチン酸イソステアリル、オレイン酸2-オクチルドデシル、イソステアリン酸イソプロピル、2-エチルヘキサン酸セチル、ジ(カプリル・カプリン酸)プロピレングリコール、ジカプリル酸プロピレングリコール、ジカプリン酸プロピレングリコール、トリカプリル酸グリセリル、トリ2-エチルヘキサン酸グリセリル、トリイソステアリン酸グリセリル、トリ(カプリル・カプリン酸)グリセリル、トリイソパルミチン酸グリセリル、トリイソステアリン酸トリメチロールプロパン、トリ2-エチルヘキサン酸トリメチロールプロパン、イソノナン酸イソノニル、イソノナン酸イソトリデシル、イソステアリン酸イソステアリル、イソステアリン酸2-ヘキシルデシル等のエステル油;スクワラン、ポリブテン、流動パラフィン、ワセリン、低比重流動パラフィン、軽質流動イソパラフィン、重質流動イソパラフィン、ポリイソブチレン等の炭化水素油;ホホバ油、アボカド油、サフラワー油、ツバキ油、ミンク油、ヒマシ油、シア油、マカデミアナッツ油、酢酸ラノリン、液状ラノリン等の油脂類;イソステアリルアルコール、オレイルアルコール等の高級アルコール類;メチルフェニルポリシロキサン、ドデカメチルシクロヘキサシロキサン、メチルハイドロジェンポリシロキサン、デカメチルシクロペンタシロキサン、オクタメチルシクロテトラシロキサン等のシリコーン油;等が挙げられる。 The liquid oil is not particularly limited as long as it can be applied to the oral cavity and is liquid at room temperature (25° C.). For example, 2-ethylhexyl palmitate, isopropyl myristate, ethyl linoleate, isopropyl palmitate, oleyl oleate, isotridecyl myristate, 2-ethylhexyl myristate, decyl oleate, isostearyl myristate, octyl myristate. Dodecyl, 2-ethylhexyl stearate, 2-hexyldecyl stearate, isostearyl palmitate, 2-octyldodecyl oleate, isopropyl isostearate, cetyl 2-ethylhexanoate, di(caprylic/capric) propylene glycol, Propylene glycol dicaprylate, propylene glycol dicaprate, glyceryl tricaprylate, glyceryl tri-2-ethylhexanoate, glyceryl triisostearate, glyceryl tri(caprylic/capric acid), glyceryl triisopalmitate, trimethylolpropane triisostearate, Ester oils such as trimethylolpropane 2-ethylhexanoate, isononyl isononanoate, isotridecyl isononanoate, isostearyl isostearate, 2-hexyldecyl isostearate; squalane, polybutene, liquid paraffin, vaseline, low density liquid paraffin, light liquid isoparaffin , heavy liquid isoparaffin, hydrocarbon oils such as polyisobutylene; fats and oils such as jojoba oil, avocado oil, safflower oil, camellia oil, mink oil, castor oil, shea oil, macadamia nut oil, acetic acid lanolin, liquid lanolin; Higher alcohols such as stearyl alcohol and oleyl alcohol; silicone oils such as methylphenylpolysiloxane, dodecamethylcyclohexasiloxane, methylhydrogenpolysiloxane, decamethylcyclopentasiloxane, and octamethylcyclotetrasiloxane; and the like.
液状油分の含有量は、本口腔用組成物に対し30%~95%である必要があり、好ましくは35~90%、より好ましくは40~85%である。液状油分の含有量は、本口腔用組成物に対し、45%以上、50%以上、55%以上、60%以上、65%以上、又は70%以上であってもよく、80%以下、75%以下、又は70%以下であってもよい。液状油分の含有量が少なすぎる場合は、口腔組織と接触する油状成分量が減少し、使用時のコーティング実感が低下する。逆に、液状油分の含有量が多すぎる場合は、口腔内での使用感に優れない。液状油分は、1種単独で又は2種以上を組み合わせて用いることができる。 The content of liquid oil must be 30% to 95% of the present oral composition, preferably 35 to 90%, more preferably 40 to 85%. The liquid oil content may be 45% or more, 50% or more, 55% or more, 60% or more, 65% or more, or 70% or more, and 80% or less, 75% or more, based on the present oral composition. % or less, or 70% or less. If the content of the liquid oil component is too low, the amount of the oil component that comes into contact with the oral tissues will decrease, and the coating experience during use will deteriorate. On the other hand, if the liquid oil content is too high, the feeling of use in the oral cavity will not be excellent. The liquid oil can be used alone or in combination of two or more.
ノニオン界面活性剤としては、口腔内に適用可能であるものであれば特に限定されない。例えば、ポリオキシエチレンアラキルエーテル(20E.O.)、ポリオキシエチレンオクチルドデシルエーテル、ポリオキシエチレンオレイルエーテル、ポリオキシエチレンコレステリルエーテル、ポリオキシエチレンステアリルエーテル、ポリオキシエチレンミリスチルエーテル、ポリオキシエチレンラウリルエーテル、ポリオキシエチレンセチルエーテル、ポリオキシエチレンベヘニルエーテル、ポリオキシエチレンポリオキシプロピレングリコール、ポリオキシエチレンポリオキシプロピレンセチルエーテル、ポリオキシエチレンポリオキシプロピレンデシルテトラデシルエーテル、ポリオキシエチレンポリオキシプロピレンブチルエーテル等のエーテル型;モノステアリン酸エチレングリコール、ジステアリン酸エチレングリコール、モノステアリン酸ソルビタン、モノイソステアリン酸ソルビタン、セスキイソステアリン酸ソルビタン、セスキステアリン酸ソルビタン、モノパルミチン酸ソルビタン、モノオレイン酸ソルビタン、トリオレイン酸ソルビタン、トリステアリン酸ソルビタン、親油型モノステアリン酸グリセリル、自己乳化型モノステアリン酸グリセリル等のエステル型、モノオレイン酸ポリエチレングリコール、モノステアリン酸ポリエチレングリコール、モノステアリン酸ポリオキシエチレングリセリル、イソステアリン酸ポリオキシエチレングリセリル、テトラオレイン酸ポリオキシエチレンソルビット、モノラウリン酸ポリオキシエチレンソルビット、ポリオキシエチレン硬化ヒマシ油、ジラウリン酸ポリエチレングリコール、ジステアリン酸ポリグリセリル、ジイソステアリン酸ポリグリセリル、デカオレイン酸ポリグリセリル、トリイソステアリン酸ジグリセリル、ペンタオレイン酸ポリグリセリル、モノイソステアリン酸ポリグリセリル、モノオレイン酸ポリグリセリル、モノステアリン酸ポリグリセリル、モノミリスチン酸デカグリセリル、モノラウリン酸ポリグリセリル等のエーテル・エステル型;ステアリン酸モノエタノールアミド、ステアリン酸ジエタノールアミド、ミリスチン酸ジエタノールアミド、ヤシ油脂肪酸ジエタノールアミド、ラウリン酸ジエタノールアミド等の脂肪酸アルカノールアミド型;アルキルグリコシド等が挙げられる。 The nonionic surfactant is not particularly limited as long as it can be applied in the oral cavity. For example, polyoxyethylene aracyl ether (20E.O.), polyoxyethylene octyl dodecyl ether, polyoxyethylene oleyl ether, polyoxyethylene cholesteryl ether, polyoxyethylene stearyl ether, polyoxyethylene myristyl ether, polyoxyethylene lauryl ether , polyoxyethylene cetyl ether, polyoxyethylene behenyl ether, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene decyltetradecyl ether, polyoxyethylene polyoxypropylene butyl ether, etc. Ether type; ethylene glycol monostearate, ethylene glycol distearate, sorbitan monostearate, sorbitan monoisostearate, sorbitan sesquiisostearate, sorbitan sesquistearate, sorbitan monopalmitate, sorbitan monooleate, sorbitan trioleate, Sorbitan stearate, lipophilic glyceryl monostearate, self-emulsifying glyceryl monostearate, etc., polyethylene glycol monooleate, polyethylene glycol monostearate, polyoxyethylene glyceryl monostearate, polyoxyethylene glyceryl isostearate , polyoxyethylene sorbitol tetraoleate, polyoxyethylene sorbitol monolaurate, polyoxyethylene hydrogenated castor oil, polyethylene glycol dilaurate, polyglyceryl distearate, polyglyceryl diisostearate, polyglyceryl decaoleate, diglyceryl triisostearate, polyglyceryl pentaoleate , polyglyceryl monoisostearate, polyglyceryl monooleate, polyglyceryl monostearate, decaglyceryl monomyristate, polyglyceryl monolaurate, etc.; stearic acid monoethanolamide, stearic acid diethanolamide, myristic acid diethanolamide, coconut oil. Examples include fatty acid alkanolamide types such as fatty acid diethanolamide and lauric acid diethanolamide; alkyl glycosides and the like.
ノニオン界面活性剤のHLB (Hydrophilic-Lipophilic Balance)は、本発明の効果が損なわれない範囲であれば、特に制限されない。通常は3~18程度、好ましくは4~16程度、より好ましくは5~13程度である。また、ノニオン性界面活性剤のHLB値が低すぎる場合は、歯面等の親水性口腔組織との親和性が低くなり、使用感に優れない場合がある。逆に、HLB値が高すぎる場合には、水すすぎ、唾液による希釈による製剤の離脱が促進され、組成物および組成物成分の口腔内滞留性が不十分となる場合がある。 The HLB (Hydrophilic-Lipophilic Balance) of the nonionic surfactant is not particularly limited as long as the effects of the present invention are not impaired. It is usually about 3 to 18, preferably about 4 to 16, more preferably about 5 to 13. Furthermore, if the HLB value of the nonionic surfactant is too low, the surfactant may have a low affinity with hydrophilic oral tissues such as tooth surfaces, and may not feel good when used. On the other hand, if the HLB value is too high, withdrawal of the preparation due to water rinsing and dilution with saliva may be promoted, resulting in insufficient oral retention of the composition and composition components.
ノニオン界面活性剤の含有量は、本発明の効果が損なわれない範囲であれば、特に制限されない。通常は本口腔用組成物に対し3%~40%程度、好ましくは4%~35%程度、より好ましくは5%~30%程度である。また、ノニオン性界面活性剤の含有量が少なすぎる場合は、歯面等の親水性口腔組織と油系基剤の親和性が低くなり、使用感に優れない場合がある。逆に、含有量が多すぎる場合には、使用時の刺激性が強くなる場合がある。ノニオン界面活性剤は、1種単独で又は2種以上を組み合わせて用いることができる。 The content of the nonionic surfactant is not particularly limited as long as the effects of the present invention are not impaired. The amount is usually about 3% to 40%, preferably about 4% to 35%, more preferably about 5% to 30%, based on the oral composition. Furthermore, if the content of the nonionic surfactant is too low, the affinity of the oil base with hydrophilic oral tissues such as tooth surfaces may be low, resulting in poor usability. On the other hand, if the content is too large, the irritation during use may become strong. Nonionic surfactants can be used alone or in combination of two or more.
本発明の口腔用組成物は、清涼化剤及び/又は甘味剤をさらに含むことができる。これらが含まれていることで、本発明の組成物が本質的に油系の組成物であったとしても口腔内で好適な使用感が得られるため非常に有効である。 The oral composition of the present invention can further include a cooling agent and/or a sweetening agent. By containing these, even if the composition of the present invention is essentially an oil-based composition, it is very effective because it provides a suitable feeling of use in the oral cavity.
清涼化剤としては、口腔内に適用可能であるものであれば特に限定されない。例えば、メントール類、アネトール、オイゲノール、サリチル酸メチル、リモネン、オシメン、n-デシルアルコール、シトロネール、α-テルビネオール、メチルアセタート、シトロネニルアセタート、メチルオイゲノール、シネオール、リナロール、エチルリナロール、ワニリン、チモール、ハッカ油、スペアミント油、ペパーミント油、レモン油、オレンジ油、セージ油、ローズマリー油、桂皮油、シソ油、冬緑油、チョウジ油、ユーカリ油等が挙げられる。これらの成分は香料成分の一部として配合されてもよい。 The refreshing agent is not particularly limited as long as it can be applied to the oral cavity. For example, menthols, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronel, α-terpineol, methyl acetate, citronenyl acetate, methyl eugenol, cineole, linalool, ethyl linalool, vanillin, thymol. , peppermint oil, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil, and the like. These ingredients may be blended as part of the perfume ingredients.
清涼化剤の含有量は、その効果が得られる範囲であれば、特に制限されない。通常は本口腔用組成物に対し0.01%~5%程度で含有させることができる。清涼化剤は、1種単独で又は2種以上を組み合わせて用いることができる。 The content of the refreshing agent is not particularly limited as long as the effect can be obtained. Usually, it can be contained in the oral cavity composition in an amount of about 0.01% to 5%. One type of refreshing agent can be used alone or two or more types can be used in combination.
甘味剤としては、口腔内に適用可能であるものであれば特に限定されない。例えば、サッカリンナトリウム、アセスルファームカリウム、ステビオサイド、ソルビトール、パラチニット、キシリトール、エリスリトール、ネオヘスペリジルジヒドロカルコン、グリチルリチン、ペリラルチン、タウマチン、アスパラチルフェニルアラニルメチルエステル、p-メトキシ桂皮アルデヒド等が挙げられる。 The sweetener is not particularly limited as long as it can be applied in the oral cavity. Examples include saccharin sodium, acesulfame potassium, stevioside, sorbitol, palatinit, xylitol, erythritol, neohesperidyl dihydrochalcone, glycyrrhizin, perillartin, thaumatin, asparatylphenylalanyl methyl ester, p-methoxycinnamaldehyde, and the like.
甘味剤の含有量は、その効果が得られる範囲であれば、特に制限されない。通常は本口腔用組成物に対し0.01%~30%程度で含有させることができる。甘味剤は、1種単独で又は2種以上を組み合わせて用いることができる。 The content of the sweetener is not particularly limited as long as its effect can be obtained. Usually, it can be contained in the oral cavity composition in an amount of about 0.01% to 30%. Sweeteners can be used alone or in combination of two or more.
本発明の口腔用組成物の調製方法としては、例えば、(A)成分と(B)成分とをまず撹拌し混合した後、撹拌を続けながら、当該混合物に(C)成分を加えて混合する方法が挙げられる。混合は公知の攪拌機により行うことができる。 The method for preparing the oral composition of the present invention includes, for example, first stirring and mixing the components (A) and (B), and then adding and mixing the component (C) to the mixture while continuing stirring. There are several methods. Mixing can be performed using a known stirrer.
また更に固形油分を含有させることで、固形または半固形とすることもできる。この場合の調製方法としては、(A)、(B)とともに固形油分を融点以上に加熱し、均一に混合した後(C)成分を加え、溶融状態のまま所定の容器などに流し込み、冷却または放冷する方法が挙げられる。 Furthermore, by further containing a solid oil component, it can be made solid or semi-solid. In this case, the preparation method is to heat the solid oil together with (A) and (B) above the melting point, mix uniformly, add component (C), pour it into a designated container in the molten state, cool it or One method is to let it cool.
固形油分としては、口腔内に適用可能であり、融点が50~120℃であるものであれば特に限定されない。例えば、合成炭化水素ワックス、ポリエチレンワックス、エチレン-プロピレンコポリマー、マイクロクリスタリンワックス、セレシン、パラフィン、オゾケライト、フィッシャートロプシュワックス等の炭化水素;モクロウ、カルナウバロウ、キャンデリラロウ、コメヌカロウ、ミツロウ、水素添加ホホバ油、硬化油、高級アルコール、シリコーンワックスが挙げられる。 The solid oil is not particularly limited as long as it can be applied to the oral cavity and has a melting point of 50 to 120°C. For example, hydrocarbons such as synthetic hydrocarbon wax, polyethylene wax, ethylene-propylene copolymer, microcrystalline wax, ceresin, paraffin, ozokerite, Fischer-Tropsch wax; Japanese wax, carnauba wax, candelilla wax, rice bran wax, beeswax, hydrogenated jojoba oil, Examples include hydrogenated oil, higher alcohol, and silicone wax.
固形油分の含有量は、本口腔用組成物に対し1%~30%を含有させることができ、好ましくは2~20%、より好ましくは3~15%である。固形油分の含有量は、本口腔用組成物に対し、5%以上、8%以上、又は10%以上であってもよく、15%以下、12%以下、又は10%以下であってもよい。固形油分の含有量を含まない場合は、組成物の保形性が十分ではなくなるため、固形状の形状にはならない。逆に、固形油分の含有量が多すぎる場合は、口腔内での使用時の分散性が低下する。固形油分は、1種単独で又は2種以上を組み合わせて用いることができる。 The solid oil content can be 1% to 30%, preferably 2 to 20%, more preferably 3 to 15%, based on the oral composition. The solid oil content may be 5% or more, 8% or more, or 10% or more, and may be 15% or less, 12% or less, or 10% or less with respect to the present oral composition. . If the composition does not contain any solid oil content, the composition will not have sufficient shape retention and will not be in a solid form. On the other hand, if the solid oil content is too high, the dispersibility during use in the oral cavity will decrease. The solid oil can be used alone or in combination of two or more.
液状油分及び固形油分の合計の含有量は、本口腔用組成物に対し40%~95%であり、好ましくは50~90%、より好ましくは70~90%である。液状油分の含有量は、本口腔用組成物に対し、55%以上、60%以上、65%以上、70%以上、75%以上、又は80%以上であってもよく、95%以下、90%以下、又は88%以下であってもよい。 The total content of liquid oil and solid oil is 40% to 95%, preferably 50 to 90%, more preferably 70 to 90%, based on the present oral composition. The liquid oil content may be 55% or more, 60% or more, 65% or more, 70% or more, 75% or more, or 80% or more, and 95% or less, 90% or more of the present oral composition. % or less, or 88% or less.
本発明の口腔用組成物の相状態及び分散状態は特に制限されない。相状態は例えば、O(油)相単独、W/O、O/W、W/O/W、O/W/O、Bicontinuous、高内相比乳化が挙げられる。分散状態は、可溶化、乳化、二相分離、三相分離、多相分離、固液分散が挙げられ、使用時に振とう等の外力により分散させるものでもよい。 The phase state and dispersion state of the oral composition of the present invention are not particularly limited. Examples of the phase state include O (oil) phase alone, W/O, O/W, W/O/W, O/W/O, Bicontinuous, and high internal phase ratio emulsification. Examples of the dispersion state include solubilization, emulsification, two-phase separation, three-phase separation, multiphase separation, and solid-liquid dispersion, and the dispersion may be caused by external force such as shaking during use.
本発明の口腔用組成物の剤形及び形状は特に制限されない。例えば、液体(溶液、乳液、懸濁液、粘性液等)、半固体(ゲル、軟膏、クリーム、ペースト等)、固体(錠剤、粒子状剤、カプセル剤、フィルム剤、混練物、溶融固体、ロウ状固体、弾性固体、ソフトカプセル剤等)が挙げられる。 The dosage form and shape of the oral composition of the present invention are not particularly limited. For example, liquids (solutions, emulsions, suspensions, viscous liquids, etc.), semi-solids (gels, ointments, creams, pastes, etc.), solids (tablets, granules, capsules, films, kneaded materials, molten solids, waxy solids, elastic solids, soft capsules, etc.).
本発明の口腔用組成物は、口腔用途で広く利用できる。固体の剤形の口腔用組成物としては、例えば、トローチ、グミ、ガム、歯磨剤が挙げられる。半固体の剤形の口腔用組成物としては、例えば、歯磨剤、塗布剤が挙げられる。液体の剤形の口腔用組成物としては、例えば、洗口剤、歯磨剤、口中清涼剤(スプレー等)が挙げられる。これらのうち、有効性及び安定性の観点から、歯磨剤、塗布剤、洗口剤、口中清涼剤が好ましい。口腔用組成物の製造方法は特に限定されず、剤形に応じて、それぞれの通常の方法で調製され得る。 The oral composition of the present invention can be widely used for oral applications. Oral compositions in solid dosage form include, for example, troches, gummies, gums, and dentifrices. Oral compositions in semi-solid dosage form include, for example, dentifrices and liniments. Examples of liquid oral compositions include mouthwashes, dentifrices, and mouth fresheners (sprays, etc.). Among these, from the viewpoint of effectiveness and stability, dentifrices, liniments, mouth washes, and mouth fresheners are preferred. The method for producing the oral composition is not particularly limited, and can be prepared by any conventional method depending on the dosage form.
本発明の口腔用組成物には、本発明の効果を損なわない範囲において、口腔用組成物に含有させることができる公知の成分を含ませてもよい。このような成分を加えた本発明の口腔用組成物は、例えば、(A)成分と(B)成分とを混合した後、(C)成分と一緒に当該成分を加えて混合する方法により調製することができる。 The oral composition of the present invention may contain known components that can be contained in oral compositions within a range that does not impair the effects of the present invention. The oral composition of the present invention containing such components can be prepared, for example, by mixing components (A) and (B), and then adding and mixing the components together with component (C). can do.
このような公知の成分としては、例えば、湿潤剤、発泡剤、増粘剤、研磨剤、矯味剤、収れん剤、pH調整剤、着色剤、防腐剤、有効成分等が挙げられる。なお、このような公知の成分は、1種単独で又は2種以上を組み合わせて用いることができる。 Examples of such known components include wetting agents, foaming agents, thickeners, abrasives, flavoring agents, astringents, pH adjusters, coloring agents, preservatives, and active ingredients. Note that such known components can be used alone or in combination of two or more.
湿潤剤としては、例えば、エタノール、エチレングリコール、プロパンジオール、ポリエチレングリコール、プロピレングリコール、1,3-ブチレングリコール、グリセリン、ソルビットが挙げられる。 Examples of wetting agents include ethanol, ethylene glycol, propanediol, polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, and sorbitol.
発泡剤としては、例えば、ラウリル硫酸ナトリウム、ラウロイルサルコシンナトリウム、ドデシルベンゼンスルホン酸ナトリウム、ラウリルスルホ酢酸ナトリウム、N-ラウリルジアミノエチルグリシン、ラウリルスルホコハク酸ナトリウム、N-パルミトイルグルタミン酸ナトリウム、N-メチル-N-アシルタウリンナトリウム、α-オレフィンスルホン酸ナトリウム、ラウリルジメチルアミノ酢酸ベタイン、ヤシ油脂肪酸アミドプロピルジメチルアミノ酢酸ベタイン、N-ヤシ油脂肪酸アシル-N-カルボキシメチル-N-ヒドロキシエチルイミダゾリニウムベタイン、ヤシ油脂肪酸アミドプロピルベタイン等が挙げられる。 Examples of the blowing agent include sodium lauryl sulfate, sodium lauroyl sarcosine, sodium dodecylbenzenesulfonate, sodium lauryl sulfoacetate, N-lauryldiaminoethylglycine, sodium lauryl sulfosuccinate, sodium N-palmitoylglutamate, N-methyl-N- Sodium acyl taurine, sodium α-olefin sulfonate, betaine lauryldimethylaminoacetate, betaine coconut oil fatty acid amidopropyldimethylaminoacetate, N-coco fatty acid acyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, coconut oil Examples include fatty acid amidopropyl betaine.
増粘剤としては、例えば、カルボキシメチルセルロースナトリウム、ヒドロキシプロピルセルロース、ヒドロキシエチルセルロース、ジェランガム、キサンタンガム、アラビヤガム、カラギーナン、増粘性シリカ等が挙げられる。 Examples of the thickener include sodium carboxymethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, gellan gum, xanthan gum, gum arabic, carrageenan, and thickening silica.
研磨剤としては、例えば、無水ケイ酸、ケイ酸カルシウム、炭酸カルシウム、ピロリン酸カルシウム、リン酸カルシウム、酸化アルミニウム、水酸化アルミニウム、ベントナイト、ヒドロキシアパタイト等が挙げられる。 Examples of the polishing agent include anhydrous silicic acid, calcium silicate, calcium carbonate, calcium pyrophosphate, calcium phosphate, aluminum oxide, aluminum hydroxide, bentonite, and hydroxyapatite.
矯味剤としては、例えば、チャエキス、チャ乾留液、塩化マグネシウム、プロポリスエキス、グルタミン酸ナトリウム等が挙げられる。 Examples of the flavoring agent include tea extract, tea carbonization solution, magnesium chloride, propolis extract, and sodium glutamate.
収れん剤としては、例えば、乳酸アルミニウム、炭酸水素ナトリウム、塩化亜鉛、酸化亜鉛等が挙げられる。 Examples of the astringent include aluminum lactate, sodium hydrogen carbonate, zinc chloride, and zinc oxide.
pH調整剤としては、例えば、クエン酸、リン酸、乳酸、ピロリン酸、リンゴ酸、フィチン酸、酒石酸、グリセロリン酸、硝酸、酢酸、またはこれらの化学的に可能な塩;水酸化ナトリウム、ケイ酸ナトリウム等が挙げられる。 Examples of pH adjusting agents include citric acid, phosphoric acid, lactic acid, pyrophosphoric acid, malic acid, phytic acid, tartaric acid, glycerophosphoric acid, nitric acid, acetic acid, or chemically possible salts thereof; sodium hydroxide, silicic acid. Examples include sodium.
着色剤としては、例えば、青色1号、緑3号、黄色4号、群青、紺青、酸化チタン、雲母チタン等が挙げられる。 Examples of the coloring agent include Blue No. 1, Green No. 3, Yellow No. 4, ultramarine, deep blue, titanium oxide, titanium mica, and the like.
防腐剤としては、例えば、メチルパラベン、エチルパラベン、プロピルパラベン、ブチルパラベン、安息香酸ナトリウム、塩酸アルキルジアミノエチルグリシン、フェノキシエタノール等が挙げられる。 Examples of the preservative include methylparaben, ethylparaben, propylparaben, butylparaben, sodium benzoate, alkyldiaminoethylglycine hydrochloride, and phenoxyethanol.
有効成分としては、例えば、アズレンスルホン酸ナトリウム、ε-アミノカプロン酸、アラントイン、アルミニウムクロルヒドロキシアラントイン、ジヒドロコレステロール、塩化ナトリウム、グリチルリチン酸類、グリチルレチン酸、イソプロピルメチルフェノール、塩化セチルピリジニウム、デカリニウム塩化物、塩化ベンザルコニウム、塩化ベンゼトニウム、クロルヘキシジン塩類、トリクロサン、アスコルビン酸またはその塩、塩酸ピリドキシン、酢酸-dl-α-トコフェロール、ニコチン酸-dl-α-トコフェロール、ゼオライト、ピロリン酸ナトリウム、ポリリン酸ナトリウム等の縮合リン酸塩、フッ化ナトリウム、モノフルオロリン酸ナトリウム、フッ化第一スズ、ポリエチレングリコール、ポリビニルピロリドン、塩化リゾチーム、銅クロロフィリンナトリウム、ヒノキチオール、ポリオキシエチレンラウリルエーテル、ラウロイルサルコシンナトリウム、硝酸カリウム、塩化カリウム、乳酸アルミニウム、酢酸ストロンチウム、シクロデキストリン類、デキストラナーゼ、ムタナーゼ、アミラーゼ、プロテアーゼ、溶菌酵素、生体活性ガラス、トラネキサム酸、グルコン酸銅、ピロリドンカルボン酸、アルギニン、リジン、シトルリン、オルニチン、クレアチン、ヒスチジン、ジアミノブタン酸、ジアミノプロピオン酸、フラボノイド、植物抽出物、乳酸菌、過酸化水素等が挙げられる。 Examples of active ingredients include sodium azulene sulfonate, ε-aminocaproic acid, allantoin, aluminum chlorohydroxyallantoin, dihydrocholesterol, sodium chloride, glycyrrhizic acids, glycyrrhetinic acid, isopropylmethylphenol, cetylpyridinium chloride, dequalinium chloride, benzyl chloride. Condensed phosphorus such as ruconium, benzethonium chloride, chlorhexidine salts, triclosan, ascorbic acid or its salts, pyridoxine hydrochloride, dl-α-tocopherol acetate, dl-α-tocopherol nicotinic acid, zeolite, sodium pyrophosphate, sodium polyphosphate, etc. Acid acid, sodium fluoride, sodium monofluorophosphate, stannous fluoride, polyethylene glycol, polyvinylpyrrolidone, lysozyme chloride, sodium copper chlorophyllin, hinokitiol, polyoxyethylene lauryl ether, sodium lauroyl sarcosine, potassium nitrate, potassium chloride, lactic acid Aluminum, strontium acetate, cyclodextrins, dextranase, mutanase, amylase, protease, lytic enzyme, bioactive glass, tranexamic acid, copper gluconate, pyrrolidone carboxylic acid, arginine, lysine, citrulline, ornithine, creatine, histidine, diamino Examples include butanoic acid, diaminopropionic acid, flavonoids, plant extracts, lactic acid bacteria, hydrogen peroxide, and the like.
本発明の口腔用組成物は、 着色除去効果及び又は漂白効果を有する水溶性高分子をさらに含むことができる。これらが含まれていることで、本発明の組成物の美白効果を更に高めることができるため非常に有効である。着色除去効果及び又は漂白効果を有する水溶性高分子は1種単独で又は2種以上を組み合わせて用いることができる。 The oral composition of the present invention may further contain a water-soluble polymer having a color removal effect and/or a bleaching effect. By including these, the whitening effect of the composition of the present invention can be further enhanced, which is very effective. Water-soluble polymers having a color removal effect and/or a bleaching effect can be used alone or in combination of two or more types.
着色除去効果及び又は漂白効果を有する水溶性高分子としては、ポリエチレングリコール等のポリオール類;ポリビニルピロリドン等のポリビニルポリマー類等が挙げられる。 Examples of water-soluble polymers having a color removal effect and/or a bleaching effect include polyols such as polyethylene glycol; polyvinyl polymers such as polyvinylpyrrolidone, and the like.
本発明は、さらに口腔用組成物と、電動歯ブラシを併用することによる歯のステインを除去する方法に関する。本発明の組成物を電動歯ブラシと組み合わせて使用することによって、歯のステインを効率よく除去することができる。 The present invention further relates to a method for removing stains from teeth by using an oral composition in combination with an electric toothbrush. By using the composition of the present invention in combination with an electric toothbrush, stains on teeth can be efficiently removed.
以下、本発明をより具体的に説明するが、本発明は下記の例に限定されるものではない。各表に記載される各成分の配合量値も特に断らない限り「質量%」を示す。 The present invention will be explained in more detail below, but the present invention is not limited to the following examples. The blending amount values of each component listed in each table also indicate "mass %" unless otherwise specified.
《口腔用組成物の調製1》
表1に示す組成(数値は質量%を示す)に従い、固形組成物を常法によって調製した 。得られた歯磨剤組成物をサンプルとして用い、下記方法で評価した。結果を表に併記した。
《Preparation of oral composition 1》
A solid composition was prepared by a conventional method according to the composition shown in Table 1 (numbers indicate mass %). The obtained dentifrice composition was used as a sample and evaluated by the following method. The results are also listed in the table.
(歯面コーティング実感 評価方法)
被験者パネラー4名によって口腔用組成物の歯面コーティング実感を評価した。サンプルの固形組成物0.5gを歯ブラシにとり、口腔全体を3分間ブラッシングしてから吐き出した。ブラッシング中(口腔内に固形組成物をいきわたらせている最中)の歯面コーティング実感について、それぞれ下記に示す評点基準によって判定した。4名の点数の平均を求め、下記の評価基準によって評価した。なお、ここで、歯面コーティング実感とは、口腔内に分散した組成物が歯面にまとわり付いている実感である。
(Tooth surface coating actual evaluation method)
A panel of four test subjects evaluated the tooth surface coating effect of the oral composition. 0.5 g of the sample solid composition was placed on a toothbrush, and the entire oral cavity was brushed for 3 minutes, and then spitted out. The sensation of tooth surface coating during brushing (during the dissemination of the solid composition into the oral cavity) was evaluated according to the scoring criteria shown below. The average of the scores of the four participants was calculated and evaluated according to the following evaluation criteria. Note that the feeling of tooth surface coating here refers to the feeling that the composition dispersed in the oral cavity clings to the tooth surface.
[評価基準]
4点:コーティング実感がかなりあった
3点:コーティング実感がややあった
2点:コーティング実感がほとんどなかった
1点:コーティング実感がなかった
[Evaluation criteria]
4 points: There was a strong feeling of coating. 3 points: There was a slight feeling of coating. 2 points: There was almost no feeling of coating. 1 point: There was no feeling of coating.
[4段階判定基準]
◎:平均点が3.5点以上
○:平均点が3.0点以上、3.5点未満
△:平均点が2.0点以上、3.0点未満
×:平均点が2.0点未満
[4-stage judgment criteria]
◎: Average score is 3.5 points or more ○: Average score is 3.0 points or more, less than 3.5 points △: Average score is 2.0 points or more, less than 3.0 points ×: Average score is 2.0 points less than a point
(香味使用感 評価方法)
被験者パネラー4名によって口腔用組成物の使用感を評価した。サンプルの固形組成物0.5gを歯ブラシにとり、口腔全体を3分間ブラッシングしてから吐き出した。ブラッシング中(口腔内に固形組成物をいきわたらせている最中)の香味について、それぞれ下記に示す評点基準によって判定した。4名の点数の平均を求め、下記の評価基準によって評価した。
(Flavor usability evaluation method)
The feeling of use of the oral composition was evaluated by a panel of four test subjects. 0.5 g of the sample solid composition was placed on a toothbrush, and the entire oral cavity was brushed for 3 minutes, and then spitted out. The flavor during brushing (during the dissemination of the solid composition into the oral cavity) was evaluated according to the scoring criteria shown below. The average of the scores of the four participants was calculated and evaluated according to the following evaluation criteria.
[評価基準]
4点:口腔内で不快感(異味・不快なにおい)を感じなかった
3点:口腔内で不快感(異味・不快なにおい)をほとんど感じなかった
2点:口腔内で不快感(異味・不快なにおい)をやや感じた
1点:口腔内で不快感(異味・不快なにおい)をかなり感じた
[Evaluation criteria]
4 points: I didn't feel any discomfort (strange taste, unpleasant smell) in my mouth 3 points: I almost didn't feel any discomfort (strange taste, unpleasant smell) inside my mouth 2 points: I didn't feel any discomfort (strange taste, unpleasant smell) inside my mouth 1 point: I felt quite a bit of discomfort (unpleasant taste/odor) in my mouth.
[4段階判定基準]
◎:平均点が3.5点以上
○:平均点が3.0点以上、3.5点未満
△:平均点が2.0点以上、3.0点未満
×:平均点が2.0点未満
[4-stage judgment criteria]
◎: Average score is 3.5 points or more ○: Average score is 3.0 points or more, less than 3.5 points △: Average score is 2.0 points or more, less than 3.0 points ×: Average score is 2.0 points less than a point
表1に示されるように、実施例1~8の口腔用組成物は、良好な歯面コーティング実感、使用感を示した。実施例9の口腔用組成物は、清涼化剤等を含んでいないため、使用感は良くなかったものの、良好な歯面コーティング実感を示した。 As shown in Table 1, the oral compositions of Examples 1 to 8 exhibited good tooth surface coating feeling and feeling of use. Although the oral cavity composition of Example 9 did not have a good feeling in use because it did not contain a refreshing agent, it showed a good tooth surface coating feeling.
《口腔用組成物の調製2》
表2に示す組成(数値は質量%を示す)に従い、液状組成物を常法によって調製した。得られた歯磨剤組成物をサンプルとして用い、下記方法で評価した。結果を表に併記した。
《Preparation of oral composition 2》
A liquid composition was prepared by a conventional method according to the composition shown in Table 2 (numbers indicate mass %). The obtained dentifrice composition was used as a sample and evaluated by the following method. The results are also listed in the table.
(歯面コーティング実感 評価方法)
被験者パネラー4名によって口腔用組成物の歯面コーティング実感を評価した。サンプルの液状組成物10mLを口に含み、20秒間すすいでから吐き出した。すすぎ中(口腔内に液状組成物をいきわたらせている最中)の歯面コーティング実感について、それぞれ下記に示す評点基準によって判定した。4名の点数の平均を求め、下記の評価基準によって評価した。なお、ここで、歯面コーティング実感とは、口腔内に分散した組成物が歯面にまとわり付いている実感である。
(Tooth surface coating actual evaluation method)
A panel of four test subjects evaluated the tooth surface coating effect of the oral composition. 10 mL of the sample liquid composition was placed in the mouth, rinsed for 20 seconds, and then spitted out. The tooth surface coating feeling during rinsing (during dispersion of the liquid composition into the oral cavity) was evaluated according to the scoring criteria shown below. The average of the scores of the four participants was calculated and evaluated according to the following evaluation criteria. Note that the feeling of tooth surface coating here refers to the feeling that the composition dispersed in the oral cavity clings to the tooth surface.
(香味使用感 評価方法)
被験者パネラー4名によって口腔用組成物の使用感を評価した。サンプルの液状組成物10mLを口に含み、20秒間すすいでから吐き出した。すすぎ中(口腔内に液状組成物をいきわたらせている最中)の香味について、それぞれ下記に示す評点基準によって判定した。4名の点数の平均を求め、下記の評価基準によって評価した。
(Flavor usability evaluation method)
The feeling of use of the oral composition was evaluated by a panel of four test subjects. 10 mL of the sample liquid composition was placed in the mouth, rinsed for 20 seconds, and then spitted out. The flavor during rinsing (during dispersion of the liquid composition into the oral cavity) was evaluated according to the scoring criteria shown below. The average of the scores of the four participants was calculated and evaluated according to the following evaluation criteria.
これらの評価基準及び4段階判定基準は、口腔用組成物の調製1に関して用いた基準と同一とした。 These evaluation criteria and four-step criteria were the same as those used for Preparation 1 of the oral composition.
表2に示されるように、実施例10~19の口腔用組成物は、良好な歯面コーティング実感、使用感を示した。実施例20の口腔用組成物は、清涼化剤等を含んでいないため、使用感は良くなかったものの、良好な歯面コーティング実感を示した。 As shown in Table 2, the oral compositions of Examples 10 to 19 exhibited good tooth surface coating feeling and feeling of use. Although the oral cavity composition of Example 20 did not have a good feeling of use because it did not contain a refreshing agent, it showed a good tooth surface coating feeling.
以下に本発明の口腔用組成物の処方例を示す。なお、各処方例の配合量(%)は質量%を示す。下記処方は良好な歯面コーティング実感、使用感を示した。 Prescription examples of the oral composition of the present invention are shown below. In addition, the compounding amount (%) of each prescription example shows mass %. The following formulation showed good tooth surface coating feeling and usability.
有効成分としては、例えば、アズレンスルホン酸ナトリウム、ε-アミノカプロン酸、アラントイン、アルミニウムクロルヒドロキシアラントイン、ジヒドロコレステロール、塩化ナトリウム、グリチルリチン酸類、グリチルレチン酸、イソプロピルメチルフェノール、塩化セチルピリジニウム、デカリニウム塩化物、塩化ベンザルコニウム、塩化ベンゼトニウム、クロルヘキシジン塩類、トリクロサン等が挙げられる。また、他の有効成分としてビタミン類が挙げられ、例えばアスコルビン酸またはその塩、塩酸ピリドキシン、酢酸-dl-α-トコフェロール、ニコチン酸-dl-α-トコフェロール等が挙げられる。さらに、他の有効成分としては、ゼオライト、ピロリン酸ナトリウム、ポリリン酸ナトリウム等の縮合リン酸塩、フッ化ナトリウム、モノフルオロリン酸ナトリウム、フッ化第一スズ、ポリエチレングリコール、ポリビニルピロリドン、塩化リゾチーム、銅クロロフィリンナトリウム、ヒノキチオール、ポリオキシエチレンラウリルエーテル、ラウロイルサルコシンナトリウム、硝酸カリウム、塩化カリウム、乳酸アルミニウム、酢酸ストロンチウム、シクロデキストリン類、デキストラナーゼ、ムタナーゼ、アミラーゼ、プロテアーゼ、溶菌酵素、生体活性ガラス、トラネキサム酸、グルコン酸銅、ピロリドンカルボン酸、アルギニン、リジン、シトルリン、オルニチン、クレアチン、ヒスチジン、ジアミノブタン酸、ジアミノプロピオン酸、フラボノイド、植物抽出物、乳酸菌、過酸化水素等が挙げられる。
Examples of active ingredients include sodium azulene sulfonate, ε-aminocaproic acid, allantoin, aluminum chlorohydroxyallantoin, dihydrocholesterol, sodium chloride, glycyrrhizic acids, glycyrrhetinic acid, isopropylmethylphenol, cetylpyridinium chloride, dequalinium chloride, benzyl chloride. Examples include ruconium, benzethonium chloride, chlorhexidine salts, triclosan, and the like. Other active ingredients include vitamins, such as ascorbic acid or its salts, pyridoxine hydrochloride, dl-α-tocopherol acetate, dl-α-tocopherol nicotinic acid , and the like. Furthermore, other active ingredients include zeolite, condensed phosphates such as sodium pyrophosphate and sodium polyphosphate, sodium fluoride, sodium monofluorophosphate, stannous fluoride, polyethylene glycol, polyvinylpyrrolidone, lysozyme chloride, Copper chlorophyllin sodium, hinokitiol, polyoxyethylene lauryl ether, lauroyl sarcosine sodium, potassium nitrate, potassium chloride, aluminum lactate, strontium acetate, cyclodextrins, dextranase, mutanase, amylase, protease, lytic enzyme, bioactive glass, tranexamic acid , copper gluconate, pyrrolidone carboxylic acid, arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutanoic acid, diaminopropionic acid, flavonoids, plant extracts, lactic acid bacteria, hydrogen peroxide, and the like.
Claims (11)
(B)ノニオン界面活性剤を1種以上
を含有する口腔用組成物。 (A) 30 to 95% by mass of liquid oil,
(B) An oral composition containing one or more nonionic surfactants.
A method for removing tooth stains by using the oral composition according to any one of claims 1 to 9 in combination with an electric toothbrush.
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TW112120269A TW202406531A (en) | 2022-06-03 | 2023-05-31 | Oral composition |
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WO2012124533A1 (en) * | 2011-03-11 | 2012-09-20 | ライオン株式会社 | Liquid oral composition with two separate layers |
JP2014051444A (en) * | 2012-09-06 | 2014-03-20 | Lion Corp | Two layer separation type liquid composition for oral cavity |
JP2014051445A (en) * | 2012-09-06 | 2014-03-20 | Lion Corp | Two layer separation type liquid composition for oral cavity |
JP2019011271A (en) * | 2017-06-30 | 2019-01-24 | サンスター株式会社 | Oral composition |
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WO2012124533A1 (en) * | 2011-03-11 | 2012-09-20 | ライオン株式会社 | Liquid oral composition with two separate layers |
JP2014051444A (en) * | 2012-09-06 | 2014-03-20 | Lion Corp | Two layer separation type liquid composition for oral cavity |
JP2014051445A (en) * | 2012-09-06 | 2014-03-20 | Lion Corp | Two layer separation type liquid composition for oral cavity |
JP2019011271A (en) * | 2017-06-30 | 2019-01-24 | サンスター株式会社 | Oral composition |
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