JP2023011800A - 認知症ではない患者における神経保護薬としての、ω3脂肪酸及びコリン - Google Patents
認知症ではない患者における神経保護薬としての、ω3脂肪酸及びコリン Download PDFInfo
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Abstract
Description
[0030]
[0033]以下、いくつかの定義を示す。しかしながら定義が以下の「実施形態」の項にある場合もあり、上記の見出し「定義」は、「実施形態」の項におけるそのような開示が定義ではないことを意味するものではない。
[0047]本開示の一態様において、組成物は、ω3脂肪酸とコリンとの組み合わせを含み、好ましくは、組成物は、認知症ではない個体において認知的加齢を低減させ、及び/又は認知能力を改善するのに効果的な量の組み合わせを含む。別の態様においては、認知症ではない個体の認知的加齢を低減させ及び/又は認知能力を改善するための方法は、該個体に有効量の組成物を(例えば経口的に)投与するステップを含む。
[0072]
[0074]以下の非限定的な実施例は、本開示により提供される、ω3脂肪酸と、コリンとを含む組成物の実施形態による、認知症ではない個体における認知的加齢の低減を裏付ける実験例である。
[0077]以下の非限定的な実施例は、認知症ではない個体において認知的加齢を低減させるための、本開示により提供される実施態様における組成物を例示する。
[0079]試験実施の主な目的を、神経心理学的評価の合成得点によって測定される認知機能低下を予防するための、実施例2に記載される組成物による4年間の介入の有効性を示すこととする。全試験集団は、70歳以上の主観的に記憶力に関する懸念を有する認知症ではない成人から構成し、そのうち、ベースラインにおいて低DHA状態(赤血球のω3指数<4.8%)により定義される試験集団のサブグループと、ベースラインにおいて0.5の臨床的認知症尺度(CDR)を有する試験集団の他のサブグループを設ける。
(i)BPB介入に関連する血漿栄養分濃度及びバイオマーカー(例えばホモシステイン、赤血球細胞(RBC)のDHA状態)に対する治療効果;
(ii)合成得点において使用される試験結果の個別的な分析により測定される治療効果、並びに追加神経心理学的試験のスコア(MMSE総スコア);
(iii)トレイルメイキングテスト、ロジカルメモリテスト、文字流暢性(Letter Fluency)、ストループ(Stroop)試験及び数唱(Digit Span);
(iv)CDR-SOB(Clinical Dementia Rating-Sum of Boxes)スコアの変化により測定される治療効果、及び軽症認知障害(MCI)及び認知症への変換率;
(v)参加者の結果報告に基づく、機能及び生活の質に対する治療効果:認知機能インスツルメント(Cognitive Function Instrument);EQ-5D-5L、及び応用認知-能力インスツルメント(Applied Cognition-ABilities instruments);
(vi)以下の被験者の特徴により定義されるサブグループにおける治療効果:
ベースラインにおける高血漿ホモシステイン濃度(血漿ホモシステイン≧12μmol/L)、ベースラインにおけるCAIDE(心臓血管リスク因子、老化及び認知症)リスクスコア、ベースラインにおけるアミロイドPETスキャンによるアミロイド陽性、及び遺伝子型。
(i)MRIに基づく全脳及び海馬の萎縮、並びに総白質の超強度の蓄積、動脈スピンラベリング(Arterial Spin LaBeling)によるイメージング、試験集団(アーム当たり最大500人の被験者)の代表的サブセットにおける安静時fMRI(Resting State fMRI);(ii)試験集団(アーム当たり最大500人の被験者)の代表的サブセットにおけるアミロイド/タウPET;(iii)血漿マーカー、すなわち血漿BDNF、血漿Aβ40~42及びタウタンパク質、非対称ジメチルアルギニン、ホモシステイン、血漿炎症マーカー(sCAMs、E-セレクチン、TNFα、IL1、IL6、IL10、CRP)、並びに酸化ストレスの血漿マーカー(酸化型低比重リポタンパク質(oxLDL)、F2-イソプロスタン)。
Claims (32)
- 認知的加齢の低減、治療又は予防を必要とするか、あるいは認知的加齢のリスクがある認知症ではない個体の認知的加齢を低減、治療又は予防する方法であって、ω3脂肪酸及びコリンを含む組成物を治療的に有効な量で前記個体に投与するステップを含む方法。
- 前記個体が、高齢成体である、請求項1に記載の方法。
- 前記個体が、老齢のヒトである、請求項1又は2に記載の方法。
- 前記組成物が、前記個体に少なくとも1ヶ月間、毎日経口投与される、請求項1~3のいずれか一項に記載の方法。
- 前記組成物が、一酸化窒素放出化合物を更に含む、請求項1~4のいずれか一項に記載の方法。
- 前記一酸化窒素放出化合物が、シトルリンを含む、請求項5に記載の方法。
- 前記ω3脂肪酸が、ドコサヘキサエン酸、エイコサペンタエン酸及びそれらの混合物からなる群から選択される脂肪酸を含む、請求項1~6のいずれか一項に記載の方法。
- 前記コリンが、塩化コリン、コリン重酒石酸塩、シチコリン、L-α-グリセロホスホコリン、レシチン、ホスファチジルコリン及びそれらの混合物からなる群から選択される、前記組成物の成分によって提供される、請求項1~7のいずれか一項に記載の方法。
- 前記組成物が、ビタミンB1、ビタミンB2、ビタミンB3、ビタミンB5、ビタミンB6、ビタミンB7、ビタミンB9及びビタミンB12からなる群から選択される1種以上のビタミンB類を含む、請求項1~8のいずれか一項に記載の方法。
- 前記組成物が、ビタミンC、ビタミンD、ビタミンE及びセレンからなる群から選択される1つ以上の抗酸化剤を含む、請求項1~9のいずれか一項に記載の方法。
- 前記個体がベースラインにおいて低DHA状態を有する、請求項1~10のいずれか一項に記載の方法。
- 前記個体がベースラインにおいて0.5の臨床的認知症尺度(CDR)を有する、請求項1~11のいずれか一項に記載の方法。
- 前記個体がベースラインにおいて少なくとも12μmol/Lの低血漿ホモシステイン濃度を有する、請求項1~12のいずれか一項に記載の方法。
- 前記個体がベースラインにおいて10~15の心臓血管リスク因子、老化及び認知症(Cardiovascular Risk Factors, Aging and Dementia(CAIDE))リスクスコアを有する、請求項1~13のいずれか一項に記載の方法。
- 前記個体がベースラインにおけるPETアミロイドスキャンでアミロイド陽性である、請求項1~14のいずれか一項に記載の方法。
- 前記個体が、認知機能低下のリスクを示す遺伝子型を有する、請求項1~15のいずれか一項に記載の方法。
- 前記組成物が、前記コリンの5.5mg/日~5,500mg/日を提供する一日用量で前記個体に投与される、請求項1~16のいずれか一項に記載の方法。
- 前記組成物が、1日当たり0.002mg~0.4mgのビタミンB12、好ましくは1日当たり0.02~0.07mgのビタミンB12、より好ましくは1日当たり0.03~0.05mgのビタミンB12を提供する一日用量で前記個体に投与される、請求項1~17のいずれか一項に記載の方法。
- 前記投与が、神経細胞の細胞膜流動性の改善、神経可塑性及び活性の刺激、抗炎症性の改善、認知パフォーマンスの支持又は維持、脳パフォーマンスの支持又は維持、脳の加齢の緩徐化、活発な意識及び脳の適応性の支持、健康な脳の支持又は維持、記憶力の強化、実行機能の強化、注意力の強化、健全な認知の維持、脳細胞の健康の維持をもたらす、請求項1~18のいずれか一項に記載の方法。
- 認知的加齢の低減、治療又は予防を必要とするか、あるいは認知的加齢のリスクがある認知症ではない個体の認知的加齢を低減、治療又は予防する方法であって、ω3脂肪酸及びコリンを含む組成物を治療的に有効な量で前記個体に投与するステップを含む方法。
- 脳萎縮の減少、シナプシス数の増加又は維持、アミロイド-β食作用の増加又は維持、並びに神経炎症の減少からなる群から選択される利益のうちの1つ以上を、当該利益を必要とする認知症ではない個体において得る方法であって、ω3脂肪酸と、コリンとを含む組成物を治療的に有効な量で前記個体に投与するステップを含む、方法。
- ω3脂肪酸と、コリンとの組み合わせを含む組成物であって、認知症ではない個体の認知的加齢を低減させるのに効果的な量の前記組み合わせを含む組成物。
- 前記組成物が、前記組成物の1~50重量%の量のω3脂肪酸と、5.5mg/日~5,500mg/日の量のコリンと、を含む、請求項22に記載の組成物。
- 前記組成物が、タンパク質、炭水化物、脂肪、及びこれらの組み合わせからなる群から選択される成分を含む食品製品である、請求項22又は23に記載の組成物。
- 前記組成物が、製薬上許容できる担体、希釈剤及び賦形剤からなる群から選択される成分を含む医薬組成物である、請求項22又は23に記載の組成物。
- 認知的加齢の低減、治療又は予防を必要とするか、あるいは認知的加齢のリスクがある認知症ではない個体において、認知的加齢を低減、治療又は予防するために用いられる、請求項22~25のいずれか一項に記載の組成物。
- 神経細胞の細胞膜流動性の改善、神経可塑性及び活性の刺激、抗炎症性の改善、認知パフォーマンスの支持又は維持、脳パフォーマンスの支持又は維持、脳の加齢の緩徐化、活発な意識及び脳の適応性の維持、健康な脳の支持又は維持、記憶力の強化、実行機能の強化、注意力の強化、健全な認知の維持、脳細胞の健康の維持に用いられる、請求項22~26のいずれか一項に記載の組成物。
- 認知症ではない個体の認知的加齢を低減させるための食品組成物を製造する方法であって、タンパク質、炭水化物及び脂質からなる群から選択される少なくとも1つの成分に、ω3脂肪酸とコリンとの組み合わせを有効量で添加するステップを含む方法。
- 認知症ではない個体の認知的加齢を低減させるための医薬組成物を製造する方法であって、製薬上許容できる担体、希釈剤及び賦形剤からなる群から選択される少なくとも1つの成分に、ω3脂肪酸とコリンとの組み合わせを有効量で添加するステップを含む方法。
- 認知症のリスクがある個体における認知症を予防する方法であって、ω3脂肪酸及びコリンを含む組成物を治療的に有効な量で前記個体に投与するステップを含む方法。
- 予防される前記認知症が、アルツハイマー病、血管性認知症、レヴィー小体認知症、前頭側頭型認知症及びそれらの組み合わせからなる群から選択される、請求項30に記載の方法。
- 認知症ではない個体において認知能力を改善する方法であって、ω3脂肪酸と、コリンとを含む組成物を治療的に有効な量で前記個体に投与するステップを含む方法。
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WO2014027882A1 (en) * | 2012-08-13 | 2014-02-20 | N.V. Nutricia | Product and method for supporting uridine homeostasis |
EP2986123A4 (en) * | 2013-03-15 | 2017-03-22 | Buck Institute For Research On Aging | Improved cognitive supplements |
US20140271844A1 (en) * | 2013-03-15 | 2014-09-18 | Nitromega Corp. | Compositions containing nitro fatty acids |
BR112017025664A2 (pt) * | 2015-06-22 | 2018-08-07 | Nestec Sa | composições e métodos para aumentar a neurogênese em animais |
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AU2017336291A1 (en) | 2019-02-21 |
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US11813233B2 (en) | 2023-11-14 |
US10821130B2 (en) | 2020-11-03 |
US20200046660A1 (en) | 2020-02-13 |
EP3518917A1 (en) | 2019-08-07 |
AU2017336292A1 (en) | 2019-02-21 |
BR112019004041A2 (pt) | 2019-05-28 |
CA3034684A1 (en) | 2018-04-05 |
AU2017336291B2 (en) | 2023-01-12 |
MX2021015377A (es) | 2022-03-02 |
MX2019003285A (es) | 2019-11-11 |
US20190209601A1 (en) | 2019-07-11 |
BR112019004055A2 (pt) | 2019-05-21 |
CA3034187A1 (en) | 2018-04-05 |
JP2019530665A (ja) | 2019-10-24 |
CN109661227A (zh) | 2019-04-19 |
CN109689041A (zh) | 2019-04-26 |
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