JP2022539086A - 可視光及びレゾルシノールを使用して皮膚疾患を治療するための組成物及び方法 - Google Patents
可視光及びレゾルシノールを使用して皮膚疾患を治療するための組成物及び方法 Download PDFInfo
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Abstract
Description
本発明は、少なくとも1つの置換レゾルシノールを含む局所用組成物を用いる。組成物は、1つ又は2以上の置換レゾルシノールを含んでもよい。
本光送達装置は、400nm~460nm、好ましくは430nm~450nmのピーク波長を有する青色光の任意の光源を備えてよい。これは、400nm~460nmのピーク波長を有する青色光を放射するのであれば、任意の形態又は構成であってよい。青色光は、連続的に、パルス状で、集中的に、拡散して、多波長で、コヒーレントに、若しくは所望の範囲内で非コヒーレントに、又は単一波長で送達されてよい。
本発明によると、少量の置換レゾルシノール及び青色光の組み合わせの投与は、抗菌性の増大、具体的には、抗キューティバクテリウムアクネス活性の増大をもたらす。このような組み合わせは、置換レゾルシノールの局所投与のみ、又は青色光への曝露のみのいずれか一方によって示される抗キューティバクテリウムアクネス活性に対して、相乗的な抗キューティバクテリウムアクネス活性をもたらすことが見出されている。
96ウェルプレートを、35℃で3日間嫌気的にインキュベートした。表1に示すように、96ウェルプレートを増殖(+)及び非増殖(-)について評価した。検証対象のウェル内の目に見える混濁の存在は、増殖を示す一方、透明なウェルは非増殖を示した。キューティバクテリウムアクネスの増殖を阻害した最小濃度をMICと決定した。陰性増殖対照(非混濁)及び陽性増殖対照(混濁)の結果は予想される通りであった。
24時間のインキュベーション後、試料を段階希釈し、強化クロストリジウム寒天(Remel,Lenexa,KS)にプレーティングした。寒天プレートを、細菌コロニーが十分に確立されるまで、35±2℃で5~7日間嫌気的にインキュベートした。次いで、コロニーを計数し、1mLあたりのコロニーフォーミングユニット(colony forming unit、CFU)を計算した。結果を表2に示す。統計的に有意な差異は、非共有文字の分類(unshared letter grouping)によって定義される。
(1) 皮膚を治療する方法であって、キューティバクテリウムアクネスによる影響を受けた疾患を有する皮膚に、約0.025重量%未満の少なくとも1種類の置換レゾルシノールを含む局所用組成物を局所的に適用することと、光送達装置を使用して、400nm~460nmのピーク波長を有する青色光に前記皮膚を曝露することと、を含む、方法。
(2) 前記皮膚疾患は、座瘡又は酒さである、実施態様1に記載の方法。
(3) 前記皮膚疾患は、座瘡である、実施態様1に記載の方法。
(4) 前記局所用組成物は、約0.002~約0.025重量パーセントの前記置換レゾルシノールを含む、実施態様1に記載の方法。
(5) 前記置換レゾルシノールは、4-ヘキシルレゾルシノールである、実施態様1に記載の方法。
(7) 前記光の強度は約2mW/cm2未満である、実施態様1に記載の方法。
(8) 前記皮膚を超音波エネルギーに曝露することを更に含む、実施態様1に記載の方法。
(9) 前記光送達装置は、光及び超音波エネルギーを送達する、実施態様8に記載の方法。
(10) (a)約0.025重量パーセント未満の少なくとも1種類の置換レゾルシノールを含む局所用組成物と、(b)400nm~460nmのピーク波長を有する青色光を送達する光送達装置と、を含む、キット。
(12) 前記置換レゾルシノールは、4-ヘキシルレゾルシノールである、実施態様10に記載のキット。
(13) 送達される前記光の強度は約20mW/cm2未満である、実施態様10に記載のキット。
(14) 送達される前記光の強度は約2mW/cm2未満である、実施態様10に記載のキット。
(15) 前記光送達装置はまた超音波エネルギーを送達する、実施態様10に記載のキット。
(17) 前記フィルムは、溶解性フィルムである、実施態様16に記載のキット。
(18) 前記フィルムは、前記フィルムに水を適用すると容易に除去可能な多層フィルムである、実施態様17に記載のキット。
(19) 前記フィルムは、グリセリン誘導体を含む下部皮膚接触層を含む、実施態様18に記載のキット。
(20) キューティバクテリウムアクネスを死滅させる方法であって、約0.025重量%未満の少なくとも1種類の置換レゾルシノールを含む組成物とキューティバクテリウムアクネスを接触させることと、光送達装置を使用して、400nm~460nmのピーク波長を有する青色光に前記キューティバクテリウムアクネスを曝露することと、を含む、方法。
Claims (20)
- (a)約0.025重量パーセント未満の少なくとも1種類の置換レゾルシノールを含む局所用組成物と、(b)400nm~460nmのピーク波長を有する青色光を送達する光送達装置と、を含む、キット。
- 前記局所用組成物は、約0.002~約0.025重量パーセントの前記置換レゾルシノールを含む、請求項1に記載のキット。
- 前記置換レゾルシノールは、4-ヘキシルレゾルシノールである、請求項1に記載のキット。
- 送達される前記光の強度は約20mW/cm2未満である、請求項1に記載のキット。
- 送達される前記光の強度は約2mW/cm2未満である、請求項1に記載のキット。
- 前記光送達装置はまた超音波エネルギーを送達する、請求項1に記載のキット。
- 前記局所用組成物はフィルムに含有されている、請求項1に記載のキット。
- 前記フィルムは、溶解性フィルムである、請求項7に記載のキット。
- 前記フィルムは、前記フィルムに水を適用すると容易に除去可能な多層フィルムである、請求項8に記載のキット。
- 前記フィルムは、グリセリン誘導体を含む下部皮膚接触層を含む、請求項9に記載のキット。
- 皮膚を治療する方法であって、キューティバクテリウムアクネスによる影響を受けた疾患を有する皮膚に、約0.025重量%未満の少なくとも1種類の置換レゾルシノールを含む局所用組成物を局所的に適用することと、光送達装置を使用して、400nm~460nmのピーク波長を有する青色光に前記皮膚を曝露することと、を含む、方法。
- 前記皮膚疾患は、座瘡又は酒さである、請求項11に記載の方法。
- 前記皮膚疾患は、座瘡である、請求項11に記載の方法。
- 前記局所用組成物は、約0.002~約0.025重量パーセントの前記置換レゾルシノールを含む、請求項11に記載の方法。
- 前記置換レゾルシノールは、4-ヘキシルレゾルシノールである、請求項11に記載の方法。
- 前記光の強度は約20mW/cm2未満である、請求項11に記載の方法。
- 前記光の強度は約2mW/cm2未満である、請求項11に記載の方法。
- 前記皮膚を超音波エネルギーに曝露することを更に含む、請求項11に記載の方法。
- 前記光送達装置は、光及び超音波エネルギーを送達する、請求項18に記載の方法。
- キューティバクテリウムアクネスを死滅させる方法であって、約0.025重量%未満の少なくとも1種類の置換レゾルシノールを含む組成物とキューティバクテリウムアクネスを接触させることと、光送達装置を使用して、400nm~460nmのピーク波長を有する青色光に前記キューティバクテリウムアクネスを曝露することと、を含む、方法。
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JP2014532672A (ja) * | 2011-10-29 | 2014-12-08 | メルク パテント ゲーエムベーハー | 光線療法に用いる美白剤 |
WO2018001485A1 (en) * | 2016-06-30 | 2018-01-04 | Symrise Ag | Medicament and cosmetic composition comprising resorcinol derivatives |
JP2018127449A (ja) * | 2017-02-08 | 2018-08-16 | ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッドJohnson & Johnson Consumer Inc. | 光及びポリカルボン酸を使用して皮膚疾患を治療するための組成物及び方法 |
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JP2014532672A (ja) * | 2011-10-29 | 2014-12-08 | メルク パテント ゲーエムベーハー | 光線療法に用いる美白剤 |
WO2018001485A1 (en) * | 2016-06-30 | 2018-01-04 | Symrise Ag | Medicament and cosmetic composition comprising resorcinol derivatives |
JP2018127449A (ja) * | 2017-02-08 | 2018-08-16 | ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッドJohnson & Johnson Consumer Inc. | 光及びポリカルボン酸を使用して皮膚疾患を治療するための組成物及び方法 |
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