JP2022538612A - 不均一なストッパインターフェースを有するプランジャーロッドを備えた薬剤送達装置 - Google Patents
不均一なストッパインターフェースを有するプランジャーロッドを備えた薬剤送達装置 Download PDFInfo
- Publication number
- JP2022538612A JP2022538612A JP2021577467A JP2021577467A JP2022538612A JP 2022538612 A JP2022538612 A JP 2022538612A JP 2021577467 A JP2021577467 A JP 2021577467A JP 2021577467 A JP2021577467 A JP 2021577467A JP 2022538612 A JP2022538612 A JP 2022538612A
- Authority
- JP
- Japan
- Prior art keywords
- stopper
- plunger rod
- delivery device
- transmission portion
- force transmission
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000012377 drug delivery Methods 0.000 title claims abstract description 26
- 230000005540 biological transmission Effects 0.000 claims abstract description 34
- 239000003814 drug Substances 0.000 claims abstract description 34
- 230000002093 peripheral effect Effects 0.000 claims abstract description 34
- 229940079593 drug Drugs 0.000 claims abstract description 26
- 230000003993 interaction Effects 0.000 claims abstract description 7
- 238000007789 sealing Methods 0.000 claims abstract description 6
- 238000006073 displacement reaction Methods 0.000 claims description 6
- 238000007906 compression Methods 0.000 claims description 2
- 230000006835 compression Effects 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 description 19
- 239000007924 injection Substances 0.000 description 19
- 239000007788 liquid Substances 0.000 description 19
- 239000000463 material Substances 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 230000003068 static effect Effects 0.000 description 6
- 230000009471 action Effects 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229940090047 auto-injector Drugs 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 101100337060 Caenorhabditis elegans glp-1 gene Proteins 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010034912 Phobia Diseases 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000000418 atomic force spectrum Methods 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002641 glycemic effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 208000019899 phobic disease Diseases 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 239000012858 resilient material Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31513—Piston constructions to improve sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31515—Connection of piston with piston rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3213—Caps placed axially onto the needle, e.g. equipped with finger protection guards
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M2005/31521—Pistons with a forward extending skirt at their front end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
- A61M2005/31598—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Environmental & Geological Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
Claims (8)
- 薬剤送達装置(1)であって、
-基準軸に沿って延在している貯蔵部本体(21)と、前記貯蔵部本体(21)内に配設された弾性ストッパ(30)と、を備える、薬剤貯蔵部(20)であって、前記弾性ストッパ(30)が、前部ストッパ端部(32)と後部ストッパ端部(34)との間に延在しており、かつ前記貯蔵部本体(21)の内壁(22)との相互作用を封止するための複数の軸方向に離間された外周リブ(33)を有する、ストッパ本体(31)を備える、薬剤貯蔵部(20)と、
-前記内壁(22)に対して前記弾性ストッパ(30)を変位させるためのプランジャーロッド構造(10)であって、前記プランジャーロッド構造(10)が、前記基準軸に沿って延在しており、かつ前記後部ストッパ端部(34)と接合するように適合された遠位端面(12、14)を備える、プランジャーロッド構造(10)と、を備え、
前記遠位端面(12、14)が、第1の力伝達部分(14)および第2の力伝達部分(12)を備え、前記第1の力伝達部分(14)が、前記第2の力伝達部分(12)を軸方向に先導し、かつ前記後部ストッパ端部(34)の周辺部分と相互作用するように適合されている、薬剤送達装置(1)。 - 前記後部ストッパ端部(34)の前記周辺部分が、半円よりも小さい、請求項1に記載の薬剤送達装置。
- 前記第2の力伝達部分(12)が、前記基準軸に対して直交しており、前記第1の力伝達部分(14)が、前記第2の力伝達部分(12)から遠位に突出するスタッド(13)の一部を形成する、請求項1または2に記載の薬剤送達装置。
- 前記スタッド(13)が、[1mm,2mm]の範囲の軸方向寸法を有する、請求項3に記載の薬剤送達装置。
- 前記スタッド(13)が、2mmの最大放射方向寸法を有する、請求項3または4に記載の薬剤送達装置。
- 前記スタッド(13)が、前記複数の軸方向に離間された外周リブ(33)のうちの1つと前記内壁(22)との間の界面で、前記後部ストッパ端部(34)に当接するように適合されている、請求項3~5のいずれか一項に記載の薬剤送達装置。
- ハウジング(2)をさらに備え、前記プランジャーロッド構造(10)が、前記ハウジング(2)に対して遠位に前記プランジャーロッド構造(10)を変位させるように解放可能な圧縮ばね要素(80)を収容するように適合された中空内部を備える、請求項1~6のいずれか一項に記載の薬剤送達装置。
- 前記薬剤貯蔵部(20)が、前記弾性ストッパ(30)の遠位に配設された第2の弾性ストッパ(40)と、前記内壁(22)に対する前記弾性ストッパ(30)の変位中に流体流が前記第2の弾性ストッパ(40)を通過することを可能にするためのバイパスセクション(25)と、をさらに備える、請求項1~7のいずれか一項に記載の薬剤送達装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19183155 | 2019-06-28 | ||
EP19183155.1 | 2019-06-28 | ||
PCT/EP2020/068013 WO2020260576A1 (en) | 2019-06-28 | 2020-06-26 | Drug delivery device with plunger rod having nonuniform stopper interface |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2022538612A true JP2022538612A (ja) | 2022-09-05 |
Family
ID=67137577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021577467A Pending JP2022538612A (ja) | 2019-06-28 | 2020-06-26 | 不均一なストッパインターフェースを有するプランジャーロッドを備えた薬剤送達装置 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20220305211A1 (ja) |
EP (1) | EP3990058B1 (ja) |
JP (1) | JP2022538612A (ja) |
CN (1) | CN114072186A (ja) |
WO (1) | WO2020260576A1 (ja) |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4394863A (en) | 1981-10-23 | 1983-07-26 | Survival Technology, Inc. | Automatic injector with cartridge having separate sequentially injectable medicaments |
BR9507625A (pt) * | 1994-05-06 | 1997-09-23 | Nycomed Imaging As | Seringa e processo de injeção de um veiculo liquido em um paciente a partir de uma seringa |
ATE308354T1 (de) * | 1999-04-16 | 2005-11-15 | Becton Dickinson Co | Stiftförmiger injektor mit merkmalen zur automatischen substanzkombination |
WO2010139793A1 (en) | 2009-06-04 | 2010-12-09 | Novo Nordisk A/S | Mixing device with piston coupling arrangement |
DK3429666T3 (da) * | 2016-03-13 | 2022-05-23 | Injecto Group As | En sprøjte med reduceret løsrivelseskraft |
US10493207B2 (en) * | 2017-02-27 | 2019-12-03 | W. L. Gore & Associates, Inc. | Medical delivery devices having low lubricant syringe barrels |
-
2020
- 2020-06-26 US US17/619,898 patent/US20220305211A1/en active Pending
- 2020-06-26 WO PCT/EP2020/068013 patent/WO2020260576A1/en active Application Filing
- 2020-06-26 CN CN202080047512.7A patent/CN114072186A/zh active Pending
- 2020-06-26 EP EP20734064.7A patent/EP3990058B1/en active Active
- 2020-06-26 JP JP2021577467A patent/JP2022538612A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3990058B1 (en) | 2023-08-09 |
EP3990058A1 (en) | 2022-05-04 |
CN114072186A (zh) | 2022-02-18 |
US20220305211A1 (en) | 2022-09-29 |
WO2020260576A1 (en) | 2020-12-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2010255B1 (en) | A fluid infusion system, a method of assembling such system and drug reservoir for use in the system | |
JP5905462B2 (ja) | 医療用注射器具 | |
JP5297372B2 (ja) | 流体注入システム、同システムの組み立て方法及び同システムで使用される薬剤容器 | |
JP6324899B2 (ja) | 充填薬剤送出アセンブリ | |
JP2020505202A (ja) | 自動注射器デバイス | |
CN108430543A (zh) | 具有针护罩触发的自动注射器 | |
US11865310B2 (en) | Handheld drug delivery device | |
EP3697471A1 (en) | Tube crimping arrangement for drug delivery device | |
US20130138050A1 (en) | Drive mechanism with a low friction coating for a drug delivery device | |
JP6240193B2 (ja) | 注射ボタンを備えるばね荷重式注射装置 | |
JP2015518758A (ja) | 使い捨て注射器及びその押子 | |
JP2022538612A (ja) | 不均一なストッパインターフェースを有するプランジャーロッドを備えた薬剤送達装置 | |
CN111372631B (zh) | 用于无菌地转移流体的连接器 | |
JP2022516494A (ja) | 物質の分離保管のための薬剤貯蔵部 | |
US20220218911A1 (en) | Dual chamber drug reservoir and stopper therefor | |
CN117320774A (zh) | 药剂输送构件模块 | |
CN116020014A (zh) | 改进的给予装置 | |
GB2504128A (en) | Automatic injector with a skin contact element |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20230601 |
|
A871 | Explanation of circumstances concerning accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A871 Effective date: 20231016 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20231107 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20240206 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20240416 |