JP2022519397A - 擬角柱光ガイドアレイを有する高分解能深さ符号化pet検出器 - Google Patents
擬角柱光ガイドアレイを有する高分解能深さ符号化pet検出器 Download PDFInfo
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Abstract
Description
本出願は、それぞれ2019年2月15日および2019年10月16日に米国特許商標局に提出された米国特許仮出願第62/806,035号および62/915,676号の恩典を主張するものである。それぞれの仮出願の内容はその全体が参照によって本明細書に組み込まれている。
本発明は、米国国立衛生研究所によって授与された助成金第EB024849号の下、米国政府の支援を受けてなされたものである。米国政府は、本発明に関して一定の権利を有する。
Eγ=EA+EB (4)
E1=EA1+EB4
E2=EA2+EB1
E3=EA3+EB2
E4=EA4+EB3 (5)
E1=EA1+EB2
E2=EA2+EB1
E3=0.7EA2+EB2
E4=EA2+0.7EB2 (7)
wA=EA1/EA
wB=EB1/EB (8)
Claims (20)
- 複数のシンチレータ結晶を含むシンチレータアレイと、
前記シンチレータアレイの底端に提供された複数の検出器と、
前記シンチレータアレイの頂端に提供された複数の擬角柱と
を備え、
前記複数の擬角柱のうちのそれぞれの擬角柱が、前記シンチレータアレイのシンチレータ結晶の頂端間で粒子の方向を変えるように構成されており、
前記シンチレータアレイのシンチレータ結晶の第1のグループの底端が、前記複数の検出器のうちの第1の検出器に粒子を導くように構成されており、
前記シンチレータアレイのシンチレータ結晶の第2のグループの底端が、前記第1の検出器と実質的に隣り合う第2の検出器に粒子を導くように構成されている、
粒子検出装置。 - それぞれの前記擬角柱が、少なくとも1つの角柱、少なくとも1つの反角柱、少なくとも1つの切頭体、少なくとも1つの三角形、少なくとも1つのキュポラ、少なくとも1つの平行六面体、少なくとも1つのくさび形、少なくとも1つの角錐、少なくとも1つの角錐台、球の少なくとも一部分のうちの少なくとも1つとして実質的に形づくられている、請求項1に記載の装置。
- 前記第1のグループが4つの結晶を含み、前記第2のグループが4つの結晶を含む、請求項1に記載の装置。
- 前記第1のグループと前記第2のグループが、前記4つの結晶のうちの隣り合う2つの結晶を共有している、請求項3に記載の装置。
- 前記共有されている結晶が、前記第1の検出器と前記第2の検出器の両方に粒子を導くように構成されている、請求項4に記載の装置。
- 前記複数の擬角柱のうちの第1の擬角柱が、前記シンチレータアレイの一群の9つの結晶の頂端間で粒子の方向を変えるように構成されている、請求項1に記載の装置。
- 前記一群の9つの結晶のうちのセンタ結晶が、隣り合う4つの検出器に粒子を導くように構成されている、請求項6に記載の装置。
- 前記複数の擬角柱のうちの第2の擬角柱が、前記シンチレータアレイの別の一群の9つの結晶の頂端間で粒子の方向を変えるように構成されている、請求項6に記載の装置。
- 前記第1の擬角柱が、前記第2の擬角柱と実質的に隣り合っており、前記一群の9つの結晶が、前記別の一群の9つの結晶と実質的に隣り合っている、請求項8に記載の装置。
- 前記複数の擬角柱のうちのコーナ擬角柱が、前記シンチレータアレイの一群の5つの結晶の頂端間で粒子の方向を変えるように構成されている、請求項1に記載の装置。
- 前記複数の擬角柱のうちのエッジ擬角柱が、前記シンチレータアレイの一群の5つの結晶の頂端間で粒子の方向を変えるように構成されている、請求項1に記載の装置。
- 複数のシンチレータ結晶を含むシンチレータアレイと、
前記シンチレータアレイの底端に提供された複数の検出器と、
前記シンチレータアレイの頂端に提供された複数の擬角柱と、
前記複数の検出器と操作可能に通信する少なくとも1つのプロセッサと
を備え、
前記少なくとも1つのプロセッサが、前記複数のシンチレータ結晶のうちの少なくとも1つのシンチレータ結晶内の少なくとも1つの相互作用サイトの3次元(3D)ガンマ線ローカライゼーションを実行するように構成された複数の教師あり機械学習アルゴリズムを含む、
粒子検出器。 - 前記少なくとも1つのプロセッサがさらに、前記複数のシンチレータ結晶間で散乱している少なくとも1つのコンプトン事象を回復し、前記少なくとも1つのコンプトン事象を、3Dガンマ線ローカライゼーションに基づいてシンチレータレベルにおいてローカライズするように構成された、請求項12に記載の検出器。
- 前記少なくとも1つのプロセッサがさらに、少なくとも1つのコンプトン事象および深さ方向の相互作用位置(DOI)情報に基づいて散乱角を決定するように構成された、請求項12に記載の検出器。
- 前記少なくとも1つのプロセッサがさらに、前記複数のシンチレータ結晶内で吸収された少なくとも2つの相互作用の分解されたエネルギーに基づいて、少なくとも1つのコンプトン事象をローカライズするように構成された、請求項12に記載の検出器。
- 前記分解されたエネルギーが、少なくとも1つの光共有パターンに基づく、請求項15に記載の検出器。
- 前記少なくとも1つの光共有パターンが、前記複数の検出器および前記複数の擬角柱に対する前記複数のシンチレータ結晶の位置に基づく、請求項15に記載の検出器。
- 前記少なくとも1つの光共有パターンが、同じ擬角柱のシンチレータ結晶間の光共有比に基づいてマッピングされる、請求項16に記載の検出器。
- 前記光共有比が、前記複数の擬角柱のうちの少なくとも1つの擬角柱の予め決められたジオメトリに基づく、請求項18に記載の検出器。
- 前記マッピングが、測定された光電事象、少なくとも1つの1次相互作用の分解されたエネルギーおよび少なくとも1つの2次相互作用に基づき、
前記少なくとも1つの1次相互作用が電子反跳に基づき、前記少なくとも1つの2次相互作用がガンマ線散乱に基づく、
請求項18に記載の検出器。
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US62/915,676 | 2019-10-16 | ||
PCT/US2020/018309 WO2020168205A1 (en) | 2019-02-15 | 2020-02-14 | High resolution depth-encoding pet detector with prismatoid light guide array |
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