JP2022144014A5 - - Google Patents
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- JP2022144014A5 JP2022144014A5 JP2021044847A JP2021044847A JP2022144014A5 JP 2022144014 A5 JP2022144014 A5 JP 2022144014A5 JP 2021044847 A JP2021044847 A JP 2021044847A JP 2021044847 A JP2021044847 A JP 2021044847A JP 2022144014 A5 JP2022144014 A5 JP 2022144014A5
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- extract
- horsetail
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- fennel
- expression
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- 239000000284 extract Substances 0.000 claims description 73
- 241000195955 Equisetum hyemale Species 0.000 claims description 44
- 229940072117 fennel extract Drugs 0.000 claims description 18
- 235000005158 Thymus praecox ssp. arcticus Nutrition 0.000 claims description 13
- 235000004054 Thymus serpyllum Nutrition 0.000 claims description 13
- 239000012138 yeast extract Substances 0.000 claims description 12
- 229940041514 candida albicans extract Drugs 0.000 claims description 11
- 239000004480 active ingredient Substances 0.000 claims description 8
- 244000184734 Pyrus japonica Species 0.000 claims description 3
- 102000011727 Caspases Human genes 0.000 claims 1
- 108010076667 Caspases Proteins 0.000 claims 1
- 240000006001 Thymus serpyllum Species 0.000 claims 1
- 102000004958 Caspase-14 Human genes 0.000 description 22
- 108090001132 Caspase-14 Proteins 0.000 description 22
- 241000754257 Thymus praecox Species 0.000 description 12
- 230000001737 promoting effect Effects 0.000 description 9
- 239000002537 cosmetic Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 235000020765 fenugreek extract Nutrition 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000002156 mixing Methods 0.000 description 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 241000212314 Foeniculum Species 0.000 description 2
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 241000228212 Aspergillus Species 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
- 241000269841 Thunnus albacares Species 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- -1 conditioners Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 206010021198 ichthyosis Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000002420 orchard Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Description
このような課題を解決するために、本発明は、酵母抽出物、ワイルドタイム抽出物、ウイキョウ抽出物、ジュウヤク抽出物、オウバク抽出物、オウレン抽出物、スギナ抽出物及びインチンコウ抽出物から選ばれる1種または2種以上を有効成分として含有するカスパーゼ-14発現促進剤を提供する。 In order to solve these problems, the present invention provides an extract selected from yeast extract , wild thyme extract, fennel extract, fenugreek extract , horsetail extract, horsetail extract, horsetail extract, and horsetail extract. A caspase-14 expression promoter containing one or more types as active ingredients is provided.
本実施形態における有効成分を得るために使用される抽出原料は、酵母、ワイルドタイム、ウイキョウ、ジュウヤク、オウバク、オウレン、スギナ及びインチンコウである。 The extraction raw materials used to obtain the active ingredient in the present embodiment are yeast , wild thyme, fennel, fennel , horsetail, horsetail, horsetail, and horsetail.
以上のようにして得られる酵母抽出物、ワイルドタイム抽出物、ウイキョウ抽出物、ジュウヤク抽出物、オウバク抽出物、オウレン抽出物、スギナ抽出物及びインチンコウ抽出物は、カスパーゼ-14発現促進作用を有しているため、その作用を利用してカスパーゼ-14発現促進剤の有効成分として用いられ得る。 The yeast extract , wild thyme extract, fennel extract, fenugreek extract, aspergillus extract, orientalis extract, horsetail extract, and horsetail extract obtained as described above have an effect of promoting caspase-14 expression. Therefore, it can be used as an active ingredient of a caspase-14 expression promoter by utilizing its action.
なお、本実施形態に係るカスパーゼ-14発現促進剤においては、酵母抽出物、ワイルドタイム抽出物、ウイキョウ抽出物、ジュウヤク抽出物、オウバク抽出物、オウレン抽出物、スギナ抽出物及びインチンコウ抽出物のうちのいずれか1種を上記有効成分として用いてもよいし、それらのうちの2種以上を混合して上記有効成分として用いてもよい。酵母抽出物、ワイルドタイム抽出物、ウイキョウ抽出物、ジュウヤク抽出物、オウバク抽出物、オウレン抽出物、スギナ抽出物及びインチンコウ抽出物のうちの2種以上を混合して上記有効成分として用いる場合、その配合比は、それらの作用の程度に応じて適宜決定されればよい。 In addition, in the caspase-14 expression promoter according to the present embodiment, yeast extract , wild thyme extract, fennel extract, fennel extract, horsetail extract, horsetail extract, horsetail extract, horsetail extract, and horsetail extract. Any one of them may be used as the above active ingredient, or two or more of them may be mixed and used as the above active ingredient. When using a mixture of two or more of yeast extract , wild thyme extract, fennel extract, fenugreek extract , horsetail extract, horsetail extract, horsetail extract, and horsetail extract as the above-mentioned active ingredient, The blending ratio may be appropriately determined depending on the degree of their effects.
本実施形態に係るカスパーゼ-14発現促進剤は、酵母抽出物、ワイルドタイム抽出物、ウイキョウ抽出物、ジュウヤク抽出物、オウバク抽出物、オウレン抽出物、スギナ抽出物及びインチンコウ抽出物から選ばれる1種または2種以上を製剤化したものであってもよい。 The caspase-14 expression promoter according to the present embodiment is one selected from yeast extract , wild thyme extract, fennel extract, fennel extract , horsetail extract, horsetail extract, horsetail extract, and horsetail extract. It may be a formulation of one species or two or more species.
本実施形態に係るカスパーゼ-14発現促進剤は、酵母抽出物、ワイルドタイム抽出物、ウイキョウ抽出物、ジュウヤク抽出物、オウバク抽出物、オウレン抽出物、スギナ抽出物及びインチンコウ抽出物が有するカスパーゼ-14発現促進作用を通じて、カスパーゼ-14の発現を促進することができる。これにより、皮膚の天然保湿因子(NMF)の産生を促進し、皮膚のバリア機能及び水分保持機能の低下を予防及び改善することができる。また、本実施形態に係るカスパーゼ-14発現促進剤は、酵母抽出物、ワイルドタイム抽出物、ウイキョウ抽出物、ジュウヤク抽出物、オウバク抽出物、オウレン抽出物、スギナ抽出物及びインチンコウ抽出物が有するカスパーゼ-14発現促進作用を通じて、アトピー性皮膚炎や魚鱗癬等の皮膚疾患を予防、治療及び改善することができる。ただし、本実施形態に係るカスパーゼ-14発現促進剤は、これらの用途以外にもカスパーゼ-14発現促進作用を発揮する意義のあるすべての用途に用いることができる。 The caspase-14 expression promoter according to the present embodiment is a caspase-14 expression promoter possessed by a yeast extract , a wild thyme extract, a fennel extract, a fenugreek extract, an orchard extract, an orensis extract, a horsetail extract, and a horsetail extract. The expression of caspase-14 can be promoted through the effect of promoting caspase-14 expression. This can promote the production of natural moisturizing factor (NMF) in the skin and prevent and improve the deterioration of the skin's barrier function and moisture retention function. Furthermore, the caspase-14 expression promoter according to the present embodiment is contained in yeast extract , wild thyme extract, fennel extract, fenugreek extract , horsetail extract, horsetail extract, horsetail extract, and horsetail extract. Through the effect of promoting caspase-14 expression, skin diseases such as atopic dermatitis and ichthyosis can be prevented, treated, and improved. However, the caspase-14 expression promoter according to the present embodiment can be used in any other meaningful applications in which it exhibits the effect of promoting caspase-14 expression.
また、本実施形態に係るカスパーゼ-14発現促進剤、又は酵母抽出物、ワイルドタイム抽出物、ウイキョウ抽出物、ジュウヤク抽出物、オウバク抽出物、オウレン抽出物、スギナ抽出物及びインチンコウ抽出物から選ばれる1種または2種以上は、優れたカスパーゼ-14発現促進作用を有するため、皮膚化粧料、頭皮化粧料、頭髪化粧料等の化粧料や、飲食品等に配合するのに好適である。 In addition, the caspase-14 expression promoter according to the present embodiment, or a yeast extract , a wild thyme extract, a fennel extract, a fenugreek extract, a horsetail extract, a horsetail extract, a horsetail extract, a horsetail extract, and a horsetail extract. One or more of these have an excellent effect of promoting caspase-14 expression, and are therefore suitable for inclusion in cosmetics such as skin cosmetics, scalp cosmetics, and hair cosmetics, as well as foods and drinks.
酵母抽出物、ワイルドタイム抽出物、ウイキョウ抽出物、ジュウヤク抽出物、オウバク抽出物、オウレン抽出物、スギナ抽出物及びインチンコウ抽出物から選ばれる1種または2種以上や、上記カスパーゼ-14発現促進剤を配合可能な化粧料としては、例えば、軟膏、クリーム、乳液、ローション、パック、ファンデーション、ヘアトニック、ヘアローション、シャンプー、リンス、石鹸等が挙げられる。上記抽出物やカスパーゼ-14発現促進剤を化粧料に配合する場合、その配合量は、化粧料の種類に応じて適宜調整することができるが、好適な配合率は、標準的な抽出物に換算して約0.0001~10質量%であり、特に好適な配合率は、標準的な抽出物に換算して約0.001~1質量%である。化粧料は、上記抽出物が有するカスパーゼ-14発現促進作用を妨げない限り、通常の化粧料の製造に用いられる主剤、助剤またはその他の成分、例えば、収斂剤、殺菌・抗菌剤、美白剤、紫外線吸収剤、保湿剤、細胞賦活剤、消炎・抗アレルギー剤、抗酸化・活性酸素除去剤、油脂類、ロウ類、炭化水素類、脂肪酸類、アルコール類、エステル類、界面活性剤、香料等を併用することができる。このように併用することで、より一般性のある製品となり、また、併用された他の有効成分との間の相乗作用が通常期待される以上の優れた効果をもたらすことがある。 One or more types selected from yeast extract , wild thyme extract, fennel extract, fennel extract, japonica extract, japonica extract, horsetail extract, horsetail extract, and caspase-14 expression promotion. Examples of cosmetics that can contain the agent include ointments, creams, milky lotions, lotions, packs, foundations, hair tonics, hair lotions, shampoos, conditioners, and soaps. When blending the above extract or caspase-14 expression promoter into cosmetics, the blending amount can be adjusted as appropriate depending on the type of cosmetic, but the suitable blending ratio is based on the standard extract. The amount is approximately 0.0001 to 10% by weight, and a particularly preferred loading is approximately 0.001 to 1% by weight, calculated as a standard extract. Cosmetics may contain main ingredients, auxiliary agents, or other ingredients used in the production of ordinary cosmetics, such as astringents, bactericidal/antibacterial agents, and whitening agents, as long as they do not interfere with the caspase-14 expression promoting effect of the extract. , UV absorbers, humectants, cell activators, anti-inflammatory/anti-allergic agents, antioxidants/active oxygen removers, oils and fats, waxes, hydrocarbons, fatty acids, alcohols, esters, surfactants, fragrances etc. can be used together. By using them in combination in this way, the product becomes more general in use, and the synergistic effect with other active ingredients used in combination may bring about better effects than would normally be expected.
〔試験例〕カスパーゼ-14mRNA発現促進作用試験
上記製造例1~3及び製造例5~9で得られた酵母抽出物、ウイキョウ抽出物、ワイルドタイム抽出物、ジュウヤク抽出物、オウバク抽出物、オウレン抽出物、スギナ抽出物及びインチンコウ抽出物について、下記の方法によりカスパーゼ-14mRNA発現促進作用の試験を実施した。
[Test Example] Caspase-14 mRNA expression promoting effect test Yeast extracts obtained in Production Examples 1 to 3 and Production Examples 5 to 9 above, fennel extract, wild thyme extract, fennel extract , orientalis extract, orientalis extract, orientalis extract The extract, horsetail extract, and horsetail extract were tested for caspase-14 mRNA expression promoting effect by the following method.
培養後に培地を除去し、各被験試料(製造例1~3及び製造例5~9の抽出物)を溶解したKGM培地を各シャーレに2mLずつ添加し、37℃・5%CO2-95%airの条件下にて24時間培養した。なお、コントロールとして、試料無添加のKGM培地を用いて同様に培養した。培養後、培地を除去し、ISOGEN II(ニッポンジーン社製,Cat. No. 311-07361)にて総RNAを抽出し、それぞれのRNA量を分光光度計にて測定し、200ng/μLになるように総RNAを調製した。 After culturing, the medium was removed, and 2 mL of KGM medium in which each test sample (extracts of Production Examples 1 to 3 and Production Examples 5 to 9) had been dissolved was added to each petri dish, and incubated at 37°C, 5% CO2, and 95% air. The cells were cultured for 24 hours under these conditions. As a control, KGM medium to which no sample was added was used and cultured in the same manner. After culturing, remove the medium, extract total RNA using ISOGEN II (manufactured by Nippon Gene Co., Ltd., Cat. No. 311-07361), measure the amount of each RNA with a spectrophotometer, and adjust the amount to 200 ng/μL. Total RNA was prepared.
表1に示すように、酵母抽出物、ウイキョウ抽出物、ワイルドタイム抽出物、ジュウヤク抽出物、キハダ抽出物、オウレン抽出物、スギナ抽出物及びインチンコウ抽出物は、いずれも高いカスパーゼ-14発現促進率を示した。この結果から、これらの抽出物は、優れたカスパーゼ-14発現促進作用を有することが確認された。 As shown in Table 1, yeast extract, fennel extract, wild thyme extract , fennel extract, yellowfin tuna extract, orensis extract, horsetail extract, and horsetail extract all highly promote the expression of caspase-14. The rate was shown. From this result, it was confirmed that these extracts had an excellent effect of promoting caspase-14 expression.
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JP2021044847A JP2022144014A (en) | 2021-03-18 | 2021-03-18 | caspase-14 expression promoter |
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JP2022144014A5 true JP2022144014A5 (en) | 2024-03-26 |
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