JP2022090658A - Adsorption and repulsion agents for fine particles - Google Patents
Adsorption and repulsion agents for fine particles Download PDFInfo
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- JP2022090658A JP2022090658A JP2020203082A JP2020203082A JP2022090658A JP 2022090658 A JP2022090658 A JP 2022090658A JP 2020203082 A JP2020203082 A JP 2020203082A JP 2020203082 A JP2020203082 A JP 2020203082A JP 2022090658 A JP2022090658 A JP 2022090658A
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- Prior art keywords
- fine particles
- agent
- repellent
- adsorbent
- adsorption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
Description
本発明は、アレルゲンやウイルス、花粉、有害微粒子等をヒトが吸入してしまう事を抑制する製品に関する。 The present invention relates to a product that suppresses human inhalation of allergens, viruses, pollen, harmful fine particles and the like.
例えば、特許文献１には、特定の両性イオン基を有するポリマー、および／または、特定のアニオン基を有するポリマーを含有する花粉吸着防止剤が記載されている。
特許文献２には、有害物質の吸入抑制製品として、有害物質を吸着する電荷を持った電荷物質と、有害物質を失活させるための特定の失活剤とを含有するものが記載されている。
For example,
Patent Document 2 describes a product for suppressing the inhalation of a harmful substance, which contains a charged substance having a charge for adsorbing the harmful substance and a specific deactivating agent for inactivating the harmful substance. ..
毛髪、顔、マスク、衣服などへの噴霧に適した優れた効果を有する製品を提供することが、本発明の課題である。 It is an object of the present invention to provide a product having an excellent effect suitable for spraying on hair, face, mask, clothes and the like.
本願の上記課題は以下の組成物、剤、製品および方法により解決される。
（１）以下の成分（ａ）が水中に溶解または分散した、プラスの電荷を有する物質を含む液状組成物、又は該組成物を含有する微粒子の吸着および反発剤：
（ａ）２-メタクリロイルオキシエチルホスホリルコリンと（２-ヒドロキシ-３-メタクリロイルオキシプロピル)トリメチルアンモニウムクロライドからなるカチオン性ポリマー。
The above problems of the present application are solved by the following compositions, agents, products and methods.
(1) A liquid composition containing a positively charged substance in which the following component (a) is dissolved or dispersed in water, or an adsorption and repulsive agent for fine particles containing the composition:
(A) A cationic polymer composed of 2-methacryloyloxyethyl phosphorylcholine and (2-hydroxy-3-methacryloyloxypropyl) trimethylammonium chloride.
（２）上記の液状組成物は、さらに以下の成分（ｂ）～（ｅ）を含むことができる：
（ｂ）触媒作用および／または抗菌作用および／または抗ウイルス作用により有害物質を失活させる失活剤；
（ｃ）ポリフェノール系脱臭剤；
（ｄ）眼鏡の曇り止め用の親水性界面活性剤；および
（ｅ）植物の蒸留水を含む賦香剤。
(2) The above liquid composition can further contain the following components (b) to (e):
(B) Inactivating agents that inactivate harmful substances by catalytic and / or antibacterial and / or antiviral activity;
(C) Polyphenol deodorant;
(D) Hydrophilic surfactant for anti-fog of eyeglasses; and (e) Perfume agent containing distilled water of plants.
（３）上記の液状組成物は、カチオン性ポリマーを０．００１～１０％（ｗ/ｖ）含有することができる。
（４）上記の液状組成物において、失活剤は、酸化亜鉛や、高級アミン・逆性石鹸に用いられる成分、例えばベンザルコニウムクロリド、ベンゼトニウムクロリドからなる群から選択される１つ又は２つ以上を含むことができる。
(3) The above liquid composition can contain 0.001 to 10% (w / v) of a cationic polymer.
(4) In the above liquid composition, the deactivating agent is one or two selected from the group consisting of zinc oxide and components used in higher amine / inverted soap, for example, benzalkonium chloride and benzethonium chloride. The above can be included.
（５）上記の液状組成物において、ポリフェノール系脱臭剤は、緑茶ポリフェノール、柿タンニンからなる群から選択される１つ又は２つ以上を含むことができる。
（６）上記の液状組成物において、親水性界面活性剤は、PEG-12ジメチコン、PEG-11メチルエーテルジメチコンからなる群から選択される、HLBが8以上のポリエーテル変性シリコーンのうちの１つ又は２つ以上を含むことができる。
(5) In the above liquid composition, the polyphenol-based deodorant can contain one or more selected from the group consisting of green tea polyphenol and persimmon tannin.
(6) In the above liquid composition, the hydrophilic surfactant is one of the polyether-modified silicones having an HLB of 8 or more, which is selected from the group consisting of PEG-12 dimethicone and PEG-11 methyl ether dimethicone. Or it can include two or more.
（７）上記の液状組成物は、包摂物で安定性をより向上させたものであることができる。
（８）上記の液状組成物は、Ζ電位が+10mV以上、望ましくは+20mV以上である。
（９）上記の液状組成物又は剤は、顔または毛髪、マスク、衣服等に噴霧して、有害微粒子の吸入を抑制するために用いることができる。
(7) The above liquid composition can be a subsumption with improved stability.
(8) The above liquid composition has a Z potential of +10 mV or more, preferably +20 mV or more.
(9) The above liquid composition or agent can be sprayed on the face or hair, mask, clothes and the like to suppress inhalation of harmful fine particles.
（１０）成分（ａ）のカチオン性ポリマーにおいて、（２-ヒドロキシ-３-メタクリロイルオキシプロピル)トリメチルアンモニウムクロライドの割合が５０％以上であることができる。 (10) In the cationic polymer of the component (a), the ratio of (2-hydroxy-3-methacryloyloxypropyl) trimethylammonium chloride can be 50% or more.
（１１）上記の液状組成物又は剤は、アレルゲンやウイルス等の有害微粒子等をヒトが吸入してしまう事を抑制するために顔または毛髪、マスク、衣服などに噴霧して用いる、液状組成物が容器に充填された噴霧剤製品の形態とすることができる。 (11) The above liquid composition or agent is a liquid composition used by spraying it on the face or hair, mask, clothes, etc. in order to prevent humans from inhaling harmful fine particles such as allergens and viruses. Can be in the form of a spray product filled in a container.
（１２）上記の剤を、顔または毛髪、マスク、衣服等に噴霧する、有害微粒子吸入抑制方法も、本発明の範囲内である。 (12) A method for suppressing the inhalation of harmful fine particles by spraying the above agent on the face or hair, mask, clothes, etc. is also within the scope of the present invention.
本発明では、カチオン性のポリマーであるポリクオタニウム－64の電荷を利用してクーロン力による吸着・反発を利用して顔やマスクに吹きかけることで、花粉やウイルス等の侵入を抑制する。さらに、ポリクオタニウム－64は、皮膚や毛髪の保湿効果を有する。 In the present invention, the invasion of pollen, virus, etc. is suppressed by spraying on the face or mask by utilizing the charge of polyquaternium-64, which is a cationic polymer, and utilizing the adsorption / repulsion by Coulomb force. In addition, Polyquaternium-64 has a moisturizing effect on the skin and hair.
さらに、本発明の組成物には、有害物質の失活を目的として触媒作用のあるもの、抗菌作用のあるもの、抗ウイルス作用のあるものが含まれている。
本発明の組成物・製品をマスクに使う場合、マスク外気側に使用する事で、有害物質吸引効果が得られる。また、マスク口側（皮膚側）に使用する事で、脱臭と当人の呼気からのウイルスなどの感染拡大が抑制される。さらに、本発明の組成物・製品においては、賦香、脱臭、眼鏡の曇り止め効果を付加している。眼鏡の曇り止めは、レンズに塗布してふき取ることで曇り止め効果を得ることができる。
Further, the composition of the present invention includes those having a catalytic action, those having an antibacterial action, and those having an antiviral action for the purpose of inactivating harmful substances.
When the composition / product of the present invention is used for a mask, a harmful substance suction effect can be obtained by using the composition / product on the outside air side of the mask. In addition, by using it on the mouth side (skin side) of the mask, deodorization and the spread of infection such as viruses from the exhaled breath of the person are suppressed. Further, in the composition / product of the present invention, fragrance, deodorization, and anti-fog effect of eyeglasses are added. The anti-fog effect of eyeglasses can be obtained by applying it to a lens and wiping it off.
本発明は、アレルゲンやウイルス、花粉、有害微粒子等をヒトが吸入してしまう事を抑制する製品において、カチオン性のポリマーの電荷を利用してクーロン力による吸着・反発を利用して吸引を防ぐ顔または毛髪、マスク、衣服などに噴霧することのできる組成物・製品を提供する。本発明の組成物は、微粒子の吸着および反発剤として使用される。 The present invention is a product that suppresses human inhalation of allergens, viruses, pollen, harmful fine particles, etc., and prevents inhalation by utilizing the charge of a cationic polymer and utilizing adsorption / repulsion by Coulomb force. Provide compositions / products that can be sprayed on the face or hair, masks, clothes, etc. The composition of the present invention is used as an adsorbent and repellent for fine particles.
１．成分
（ａ）ポリクオタニウム-６４
カチオン性のポリマーとは、カチオン性の基が導入された高分子物質である。本発明で使用される「ポリクオタニウム-６４（Polyquaternium-64）」は、２-メタクリロイルオキシエチルホスホリルコリン（略称：MPC）及びカチオンモノマーである２-ヒドロキシ-３-メタクリロイルオキシプロピル)トリメチルアンモニウムクロライド（商品名：ブレンマー（登録商標）QA）からなる、次の化学式で表わされる第４級アンモニウム塩の重合体である（日本化粧品工業連合会のホームページより）。
1. 1. Ingredients (a) Polyquaternium-64
A cationic polymer is a polymer substance into which a cationic group has been introduced. The "Polyquaternium-64" used in the present invention is 2-methacryloyloxyethyl phosphorylcholine (abbreviation: MPC) and 2-hydroxy-3-methacryloyloxypropyl trimethylammonium chloride (trade name) which is a cationic monomer. : A polymer of quaternary ammonium salt represented by the following chemical formula consisting of Blemmer (registered trademark) QA) (from the website of the Japan Cosmetic Industry Association).
ポリクオタニウム－64は、優れた皮膚浸透性・皮膚透過性を有し、皮膚刺激性が低いことから、皮膚に噴霧・塗布する組成物に配合するために好適である。現在市販されている典型的なポリクオタニウム-64（商品名：Lipidure C）は、MPC70%、カチオンモノマー30%からなる合成ポリマーである。ポリマーの分子量は60万以上であることが好ましい。しかしながら、本発明では、ポリクオタニウム－64であるカチオン性ポリマー中のMPCとカチオンモノマーの比率、およびポリマーの分子量は様々に変化させることが可能である。本発明において、ポリマー中のカチオンモノマーの割合は特に限定されず、50%以上、あるいは55%以上、あるいは60％以上であってもよい。 Polyquaternium-64 has excellent skin permeability and skin permeability, and has low skin irritation, so that it is suitable for blending in a composition to be sprayed and applied to the skin. A typical polyquaternium-64 (trade name: Lipidure C) currently on the market is a synthetic polymer consisting of 70% MPC and 30% cationic monomer. The molecular weight of the polymer is preferably 600,000 or more. However, in the present invention, the ratio of MPC to the cationic monomer in the cationic polymer of polyquaternium-64 and the molecular weight of the polymer can be varied. In the present invention, the ratio of the cationic monomer in the polymer is not particularly limited, and may be 50% or more, 55% or more, or 60% or more.
本発明の組成物において、ポリクオタニウム－64の含有量は、０．００１～１０％（ｗ/ｖ）であることが好ましく、より好ましくは０．０１～１％（ｗ/ｖ）である。 In the composition of the present invention, the content of polyquaternium-64 is preferably 0.001 to 10% (w / v), more preferably 0.01 to 1% (w / v).
（ｂ）有害物質を失活させる失活剤
本発明の組成物・製品には、有害物質の失活を目的とした物質が含まれている。本発明が対象とする有害物質は、主として、空中に漂い、ヒトが吸入してしまうことでアレルギー反応や疾患等の人体に有害な作用を引き起こす物質である。例えば、花粉、微粒子状の大気汚染物質（ＰＭ２．５等）その他のアレルゲン、病原性のウイルス、その他の有害微粒子が挙げられる。有害物質の失活のための失活剤として、触媒作用、抗菌作用、抗ウイルス作用を有する物質が使用可能である。そのような失活剤の具体例として酸化亜鉛や、高級アミン・逆性石鹸に用いられる成分、例えばベンザルコニウムクロリド、ベンゼトニウムクロリド等が挙げられる。
(B) Inactivating agent for inactivating harmful substances The composition / product of the present invention contains a substance for the purpose of inactivating harmful substances. Hazardous substances targeted by the present invention are substances that float in the air and cause harmful effects on the human body such as allergic reactions and diseases when inhaled by humans. For example, pollen, fine particles of air pollutants (PM2.5, etc.) and other allergens, pathogenic viruses, and other harmful fine particles can be mentioned. As an inactivating agent for inactivating harmful substances, substances having catalytic action, antibacterial action, and antiviral action can be used. Specific examples of such a deactivating agent include zinc oxide and components used in higher amine / inverted soap, such as benzalkonium chloride and benzethonium chloride.
（ｃ）ポリフェノール系脱臭剤
本発明の組成物・製品には、ポリフェノール系の脱臭剤が含まれている。例としては、緑茶ポリフェノールや柿タンニン等の天然物由来の物質が挙げられる。これらは、空間消臭などに使用されているが、顔や髪への噴霧においても問題なく使用可能である。
(C) Polyphenol-based deodorant The composition / product of the present invention contains a polyphenol-based deodorant. Examples include substances derived from natural products such as green tea polyphenols and persimmon tannins. Although these are used for space deodorization and the like, they can also be used without problems in spraying on the face and hair.
（ｄ）親水性界面活性剤
本発明の組成物・製品には、親水性界面活性剤が含まれている。これは、マスクして眼鏡をすることで眼鏡が曇りやすくなるため、製品の主目的に加えて、レンズに塗布してふき取ることで曇り止め効果を付加したものである。眼鏡の曇り止めの効果を示す成分として親水性の界面活性剤が使用できる。当然ながら、肌への噴霧にも問題なく使用可能な物質が好ましい。なお、一般的な親水性活性剤のうち、脂肪酸などは蒸発により原料由来のベトツキを生じる物質や、原料に起因する粘調整などが生じる物質もあり、これらは本発明の主効果を損なうことも確認している。したがって、本発明で用いる親水性界面活性剤は、ＨＬＢが８以上のポリエーテル変性シリコーンであることが好ましく、例えば、PEG-12ジメチコン、PEG-11メチルエーテルジメチコン等が挙げられる。
(D) Hydrophilic surfactant The composition / product of the present invention contains a hydrophilic surfactant. This is because the spectacles are easily fogged by masking and wearing spectacles, so in addition to the main purpose of the product, the anti-fog effect is added by applying it to the lens and wiping it off. A hydrophilic surfactant can be used as a component showing the anti-fog effect of eyeglasses. Naturally, a substance that can be used without problems for spraying on the skin is preferable. Among general hydrophilic activators, some substances such as fatty acids cause stickiness derived from raw materials due to evaporation, and some substances cause stickiness adjustment due to raw materials, and these may impair the main effect of the present invention. I'm checking. Therefore, the hydrophilic surfactant used in the present invention is preferably a polyether-modified silicone having an HLB of 8 or more, and examples thereof include PEG-12 dimethicone and PEG-11 methyl ether dimethicone.
（ｅ）賦香剤
本発明の組成物・製品には、賦香剤が含まれている。例としては、植物の蒸留水を含む物質が挙げられる。例えば、特許第4795475号に記載されたウメ抽出物、例えば、ウメ根抽出物やウメ果実蒸留水；特許第2526362号に記載されたウメ果汁醗酵液；特開2012-116761号に記載された植物由来水蒸気蒸留水、例えば、パッションフルーツ、シマミカン、バナナ、アテモヤ、ウメ、タンカン、レモンライム、ジンジャーから選択される１種又は２種以上の植物の水蒸気蒸留水；特許第3544505号に記載されたトウキ抽出物；ダマスクスバラ花水、ボスウェリアサクラ樹脂水、ラベンダー花水、その他。
(E) Perfume agent The composition / product of the present invention contains a perfume agent. Examples include substances containing distilled water from plants. For example, the sea urchin extract described in Patent No. 4795475, for example, the sea urchin root extract and the distilled water of sea urchin fruit; the fermented sea urchin juice described in Patent No. 25263362; the plant described in JP2012-116761. Derived steam distilled water, for example, steam distilled water of one or more plants selected from passion fruit, shimamican, banana, atemoya, sea urchin, tankan, lemon lime, ginger; Touki described in Patent No. 3544505. Extracts; Damask rose flower water, Boswellia cherry resin water, lavender flower water, etc.
（ｆ）包接作用を有する物質
本発明の組成物・製品には、さらに、包接化合物を形成して機能成分を安定化させる物質が含まれていてもよい。そのような物質の例として、α、β、γ-シクロデキストリンまたはその誘導体（例えば、ヒドロキシプロピルシクロデキストリン）等が挙げられる。
(F) Substance having clathrate action The composition / product of the present invention may further contain a substance that forms a clathrate compound and stabilizes functional components. Examples of such substances include α, β, γ-cyclodextrin or derivatives thereof (eg, hydroxypropylcyclodextrin) and the like.
（ｇ）その他の成分
本発明の組成物・製品には、一般に化粧品に用いられている成分（油脂類、ロウ類、炭化水素類、脂肪酸類、アルコール類、エステル類、アミノ酸類、ビタミン類、界面活性剤、pH調整剤、防腐剤、香料、保湿剤、粉体、紫外線吸収剤、増粘剤、色素、酸化防止剤、美白剤、抗炎症剤、抗しわ剤、肌荒れ改善剤、ニキビ用薬剤、アルカリ類、キレート剤、金属封鎖剤、等）を適宜配合することができる。また、保湿成分、生薬エキス、チロシナーゼ、スーパーオキシドジスムターゼ、リパーゼのような酵素、レチノール、アスコルビン酸、トコフェロール、ピリドキサール、リボフラビンのようなビタミンやその誘導体、β－カロチン、クロロフィルのような有機系色素、グリセリン、ソルビトール、尿素、乳酸、プロピレングリコール、ポリチレングリコールおよび共重合体、グルコース誘導体等のようなモイスチャー成分、パラフイン、ステアリルアルコール、セチルアルコール、スクワラン、シリコーンオイル、ステアリス等のようなエモリエント成分、トリートメント成分、フケ抑制成分、養毛、育毛成分、紫外線吸収剤、酸化防止剤、香料、防腐剤、分散のための成分、ポリクオタニウム－１０のような帯電防止剤、皮膜形成剤等を組合せて用いてもよい。
(G) Other Ingredients In the composition / product of the present invention, ingredients generally used in cosmetics (oils and fats, waxes, hydrocarbons, fatty acids, alcohols, esters, amino acids, vitamins, etc. Surfactants, pH regulators, preservatives, fragrances, moisturizers, powders, UV absorbers, thickeners, pigments, antioxidants, whitening agents, anti-inflammatory agents, anti-wrinkle agents, rough skin improvers, acne Chemicals, alkalis, chelating agents, metal sequestering agents, etc.) can be appropriately blended. Also, moisturizing ingredients, biopharmaceutical extracts, tyrosinase, superoxide dismutase, enzymes such as lipase, vitamins and derivatives such as retinol, ascorbic acid, tocopherol, pyridoxal, riboflavin, organic pigments such as β-carotene, chlorophyll, etc. Moisture ingredients such as glycerin, sorbitol, urea, lactic acid, propylene glycol, polytylene glycol and copolymers, glucose derivatives, emollient ingredients such as paraffin, stearyl alcohol, cetyl alcohol, squalane, silicone oil, stearis, etc., treatments Ingredients, fluff-suppressing ingredients, hair-growth, hair-growth ingredients, UV absorbers, antioxidants, fragrances, preservatives, ingredients for dispersion, antistatic agents such as polyquaternium-10, film-forming agents, etc. are used in combination. May be good.
２．製品
本発明は、上述の成分が水中に溶解または分散した、プラスの電荷を有する物質を含む液状組成物を、顔または毛髪、マスク、衣服などに噴霧・塗布することのできる製品として提供される。組成物がプラスに帯電していることから、空気中に浮遊する有害物質がマイナスに帯電している場合にはそれに吸着し、反対に、空気中に浮遊する有害物質がプラスに帯電している場合には反発する。本発明の組成物は、Ζ電位が+10mV以上であることが好ましく、+20mV以上であることがさらに好ましい。
2. 2. Product The present invention is provided as a product capable of spraying and applying a liquid composition containing a substance having a positive charge, in which the above-mentioned components are dissolved or dispersed in water, onto the face or hair, mask, clothes and the like. .. Since the composition is positively charged, if the harmful substances floating in the air are negatively charged, they will be adsorbed, and conversely, the harmful substances floating in the air are positively charged. In some cases it repels. The composition of the present invention preferably has a Ζ potential of +10 mV or more, and more preferably +20 mV or more.
本発明の製品は、スプレー、ローション、クリーム、ゲル、ムース等の任意の形態とすることができる。使用性の観点からは、スプレーとして用いるのが好適である（図１を参照）。使用者が、顔または毛髪、マスク、衣服などにスプレーすることで、アレルゲンやウイルス、花粉、有害微粒子等の侵入を抑制する効果が期待できる。さらに、有害物質を失活させる失活剤の作用により、マスクを通り抜けて侵入した、あるいは顔または毛髪、マスク、衣服などに吸着した有害物質による症状が現れないようにする効果が期待できる。また、植物の蒸留水を含む賦香剤がほのかに香り、気分をリフレッシュできる。また、マスクに吹きかけることで、フィルターの性能を向上させる効果が期待できる。また、眼鏡のレンズに塗布して、ティッシュなどで軽く拭くことにより、曇り止め効果が得られる。
本発明の製品は、スプレー剤として使用するために、組成物中に低級アルコール（例えばエチルアルコール等）、揮発性油（低沸点鎖状シリコーン油や環状シリコーン油、低沸点イソパラフィン系炭化水素油など）などがさらに配合されていても良い。エアロゾールタイプのスプレーとして用いる場合には、さらに適当な噴射剤（液化石油ガス（ＬＰＧ）、ジメチルエーテル（ＤＭＥ）等）が配合される。本発明の製品は、スプレー剤として使用するために適した、噴霧機構を有する容器に充填されていてもよい。
The products of the present invention can be in any form such as sprays, lotions, creams, gels, mousses and the like. From the viewpoint of usability, it is preferable to use it as a spray (see FIG. 1). When the user sprays it on the face or hair, mask, clothes, etc., it can be expected to have the effect of suppressing the invasion of allergens, viruses, pollen, harmful fine particles, and the like. Further, the action of the deactivating agent that deactivates the harmful substance can be expected to have the effect of preventing the symptoms caused by the harmful substance that has invaded through the mask or adsorbed on the face, hair, mask, clothes, or the like. In addition, the perfume agent containing distilled water of the plant has a faint scent and can refresh the mood. Also, by spraying on the mask, the effect of improving the performance of the filter can be expected. In addition, an anti-fog effect can be obtained by applying it to the lens of eyeglasses and gently wiping it with a tissue or the like.
The product of the present invention has a lower alcohol (for example, ethyl alcohol, etc.), a volatile oil (low boiling chain silicone oil, cyclic silicone oil, low boiling isoparaffin hydrocarbon oil, etc.) in the composition for use as a spray agent. ) And the like may be further blended. When used as an aerosol type spray, an appropriate propellant (liquefied petroleum gas (LPG), dimethyl ether (DME), etc.) is further blended. The product of the present invention may be packed in a container having a spraying mechanism suitable for use as a spraying agent.
以下、本発明を実施例によって具体的に説明する。なお、これらの実施例は、本発明を説明するためのものであって、本発明の範囲を限定するものではない。 Hereinafter, the present invention will be specifically described with reference to Examples. It should be noted that these examples are for explaining the present invention and do not limit the scope of the present invention.
処方例１Prescription example 1
※処方例１のポリクオタニウム-64は、市販品（MPC：カチオンモノマー＝70：30）である。
調製方法
(1) 別途用意した容器に、原料〈ヒドロキシプロピルシクロデキストリン〉および〈酸化亜鉛〉を水または蒸留水で予め混合・分散させておく。
※分散されていることを確認した後、(2)で投入すること。
(2) (1)で予め調製した溶液と(1)以外の原料を乳化釜に「水（又は蒸留水）→粉物原料→液体原料→(1)溶液」の順に投入する。
(3) (2)を65～75℃まで加温し、撹拌、均一に溶解させる。（ホモミキサー2200rpm, アンカー30rpm, 真空 0.03MPa）
(4) 35℃まで冷却しながら、撹拌する。
* Polyquaternium-64 in Formulation Example 1 is a commercially available product (MPC: cationic monomer = 70:30).
Preparation method
(1) In a separately prepared container, the raw materials <hydroxypropyl cyclodextrin> and <zinc oxide> are mixed and dispersed in advance with water or distilled water.
* After confirming that it is dispersed, put it in (2).
(2) Put the solution prepared in advance in (1) and the raw materials other than (1) into the emulsification pot in the order of "water (or distilled water)-> powder raw material-> liquid raw material-> (1) solution".
(3) Heat (2) to 65-75 ° C, stir and dissolve evenly. (Homo mixer 2200rpm, anchor 30rpm, vacuum 0.03MPa)
(4) Stir while cooling to 35 ° C.
（ア）反発効果
試験方法
プラスチック容器に処方例１を噴霧して乾燥させた後、ポリスチレンビーズを入れた。比較対象として、プラスチック容器に水を噴霧して乾燥させたものも用意した。さらに、蓋にも同様に噴霧し乾燥させた。ポリスチレンビーズの入った容器を手で強くふって、ポリスチレンビーズにプラスの電荷を発生させ、内部のポリスチレンビーズの様子を目視にて観察した。
(A) Repulsion effect Test method After spraying Formulation Example 1 on a plastic container and drying it, polystyrene beads were placed. For comparison, we also prepared a plastic container that was sprayed with water and dried. Further, the lid was similarly sprayed and dried. The container containing the polystyrene beads was shaken strongly by hand to generate a positive charge on the polystyrene beads, and the state of the polystyrene beads inside was visually observed.
結果
水を噴霧した方はポリスチレンビーズが容器内側に吸着し、処方例１を噴霧した方はポリスチレンビーズが容器内側に吸着していなかった。水噴霧では、プラスの電荷が発生したポリスチレンビーズが、マイナスの電荷をもった容器内側に吸着したが、処方例１の塗布により容器内側がプラスの電荷となり吸着しなかったことが確認された。結果を図２に示す。
As a result, the polystyrene beads were adsorbed on the inside of the container in the case of spraying water, and the polystyrene beads were not adsorbed on the inside of the container in the case of spraying Formulation Example 1. By water spraying, it was confirmed that the polystyrene beads in which a positive charge was generated were adsorbed on the inside of the container having a negative charge, but the inside of the container became a positive charge by the application of
（イ）吸着効果
試験方法
ストローの先端に処方例１をスプレー（0.15 cc吐出ポンプ：3プッシュ程度）し、乾燥させた。比較対照として、水をスプレーしたストローも同様の方法で作成した。固定台となるカップの底に虫ピンを内側から挿し、中心に穴をあけた別のストローを虫ピンの先端から通して、ストローが回転するように組み立てた。回転する側のストローをティッシュペーパーでこすり、マイナスの電荷を発生させ、ストローを近づけた際の様子を目視で観察した。
(B) Adsorption effect Test method Prescription Example 1 was sprayed on the tip of the straw (0.15 cc discharge pump: about 3 pushes) and dried. As a comparison, water-sprayed straws were made in a similar manner. An insect pin was inserted from the inside into the bottom of the cup that served as a fixing base, and another straw with a hole in the center was passed through the tip of the insect pin to assemble the straw so that it would rotate. The straw on the rotating side was rubbed with tissue paper to generate a negative charge, and the state when the straw was brought closer was visually observed.
結果
摩擦による静電気を発生させマイナスを帯びたストローに、水をスプレーしたストローを接近させても反応はなかった。一方で、処方例１をスプレーしたストローを接近させると、固定台に組み立てたストローは吸い寄せられるように回転した。水の場合、電荷を帯びていないため反応しなかったのに対し、処方例１はカチオン化ポリマーを配合するため、プラスの電荷を帯びたストローにマイナスの静電気を帯びたストロー（固定台に組み立てたストロー）が吸い寄せられて回転したことが確認された。
As a result, there was no reaction even when the straw sprayed with water was brought close to the straw that generated static electricity due to friction and was negative. On the other hand, when the straw sprayed with Formulation Example 1 was brought close to the straw, the straw assembled on the fixed base was rotated so as to be attracted. In the case of water, it did not react because it was not charged, whereas in Formulation Example 1, since it contains a cationized polymer, a straw with a positive charge and a straw with a negative static electricity (assembled on a fixed base). It was confirmed that the straw) was attracted and rotated.
（ウ）抗菌効果（発育阻止）
試験方法
450μL噴霧相当になるように処方例１を寒天培地にて希釈し、固化させた。試験菌株３菌種をミューラーヒントン液体培地にて32.5±2.5℃、22±2時間培養した。培養液0.1mLを滅菌精製水10mLと混合し、106cfu/mLになるように調製したものを接種菌液とした。白金耳を用い、調製した接種菌液で寒天培地に2cm程度画線を引き、ミューラーヒントン液体培地にて32.5±2.5℃、24時間培養した。
(C) Antibacterial effect (growth inhibition)
Test method
Formulation Example 1 was diluted with an agar medium and solidified so as to be equivalent to 450 μL spray. Three test strains were cultured in Mueller-Hinton liquid medium at 32.5 ± 2.5 ° C for 22 ± 2 hours. 0.1 mL of the culture solution was mixed with 10 mL of sterile purified water to prepare 10 6 cfu / mL, which was used as the inoculum solution. Using a platinum loop, a 2 cm line was drawn on the agar medium with the prepared inoculum solution, and the cells were cultured in Mueller-Hinton liquid medium at 32.5 ± 2.5 ° C for 24 hours.
結果
MIC法による抗菌力試験結果を図３に示す。検体含有条件で菌株３菌種について、全て発育は阻止されており、処方例１が抗菌効果を有していることが確認された。
result
The results of the antibacterial activity test by the MIC method are shown in FIG. It was confirmed that the growth of all three strains was inhibited under the sample content conditions, and that Formulation Example 1 had an antibacterial effect.
（エ）抗菌効果
試験方法
試験菌株2菌種をミューラーヒントン液体培地にて32.5±2.5℃、22±2時間培養後、滅菌精製水を用いて105～6cfu/mlになるように調製したものを菌液とした。
各菌液を0.1mlずつシャーレに分注し、そのシャーレにミューラーヒントンカンテン培地を流し込み、含菌平板を作成する。
滅菌したペーパーディスク（直径6mm）に10倍に濃縮した処方例１を15μL染み込ませ、それらを含菌寒天平板上に置き、32.5±2.5℃にて24時間培養する。
培養後、阻止円直径を0.1mmまで測定し、縦横計測したものの平均値を結果とする。
結果表の阻止円はペーパーディスク（直径6mm）を含んだ円の大きさを指す。
(D) Antibacterial effect Test method After culturing the two test strains in Mueller Hinton liquid medium at 32.5 ± 2.5 ° C for 22 ± 2 hours, the temperature was adjusted to 10 5 to 6 cfu / ml using sterile purified water. The thing was made into a bacterial solution.
Dispense 0.1 ml of each bacterial solution into a petri dish, and pour Mueller-Hintoncanten medium into the petri dish to prepare a bacterial-containing plate.
Soak 15 μL of Formulation Example 1 concentrated 10 times on a sterilized paper disc (diameter 6 mm), place them on a fungus-containing agar plate, and incubate at 32.5 ± 2.5 ° C for 24 hours.
After culturing, the diameter of the blocking circle is measured up to 0.1 mm, and the average value of the vertical and horizontal measurements is used as the result.
The blocking circle in the result table refers to the size of the circle including the paper disc (diameter 6 mm).
結果
ペーパーディスク法による抗菌力試験結果を図４に示す。水を浸み込ませた方は阻止円が確認できなかったが、処方例１を浸み込ませた方は阻止円ができており、処方例１が抗菌効果を有していることが確認された。
Results The results of the antibacterial activity test by the paper disc method are shown in FIG. The blocking circle could not be confirmed for those who were soaked in water, but the blocking circle was formed for those who were soaked in Prescription Example 1, and it was confirmed that Prescription Example 1 had an antibacterial effect. Was done.
なお、上記組成の水は、蒸留水に置換しても良い。また、上記組成には、曇り止め成分としてＰＥＧ－１２ジメチコンを添加しても良い。また、上記組成には、消臭成分としてチャ乾留液を添加しても良い。 The water having the above composition may be replaced with distilled water. Further, PEG-12 dimethicone may be added to the above composition as an anti-fog component. Further, a tea dry distillate may be added to the above composition as a deodorant component.
処方例２Prescription example 2
※処方例２のポリクオタニウム-64は、市販品（MPC：カチオンモノマー＝70：30）である。
処方例３
* Polyquaternium-64 in Formulation Example 2 is a commercially available product (MPC: cationic monomer = 70:30).
Prescription example 3
※処方例３のポリクオタニウム-64は、市販品（MPC：カチオンモノマー＝70：30）である。 * Polyquaternium-64 in Formulation Example 3 is a commercially available product (MPC: cationic monomer = 70:30).
（オ）反発効果
試験方法
プラスチック容器に処方例２を噴霧して乾燥させた後、ポリスチレンビーズを入れた。比較対象として、プラスチック容器に水を噴霧して乾燥させたものも用意した。さらに、蓋にも同様に噴霧し乾燥させた。ポリスチレンビーズの入った容器を手で強くふって、ポリスチレンビーズにプラスの電荷を発生させ、内部のポリスチレンビーズの様子を目視にて観察した。
(E) Repulsion effect Test method After spraying Formulation Example 2 on a plastic container and drying it, polystyrene beads were placed. For comparison, we also prepared a plastic container that was sprayed with water and dried. Further, the lid was similarly sprayed and dried. The container containing the polystyrene beads was shaken strongly by hand to generate a positive charge on the polystyrene beads, and the state of the polystyrene beads inside was visually observed.
結果
水を噴霧した方はポリスチレンビーズが容器内側に吸着し、処方例２を噴霧した方はポリスチレンビーズが容器内側に吸着していなかった。水噴霧では、プラスの電荷が発生したポリスチレンビーズが、マイナスの電荷をもった容器内側に吸着したが、処方例２の塗布により容器内側がプラスの電荷となり吸着しなかったことが確認された。
As a result, the polystyrene beads were adsorbed on the inside of the container in the case of spraying water, and the polystyrene beads were not adsorbed on the inside of the container in the case of spraying Formulation Example 2. By water spraying, it was confirmed that the polystyrene beads in which a positive charge was generated were adsorbed on the inside of the container having a negative charge, but the inside of the container became a positive charge by the application of Formulation Example 2 and was not adsorbed.
（カ）吸着効果
試験方法
ストローの先端に処方例２を噴霧（0.15 cc吐出ポンプ：3プッシュ程度）し、乾燥させた。比較対照として、水をスプレーしたストローも同様の方法で作成した。固定台となるカップの底に虫ピンを内側から挿し、中心に穴をあけた別のストローを虫ピンの先端から通して、ストローが回転するように組み立てた。回転する側のストローをティッシュペーパーでこすり、マイナスの電荷を発生させ、ストローを近づけた際の様子を目視で観察した。
(F) Adsorption effect Test method Prescription Example 2 was sprayed on the tip of the straw (0.15 cc discharge pump: about 3 pushes) and dried. As a comparison, water-sprayed straws were made in a similar manner. An insect pin was inserted from the inside into the bottom of the cup that served as a fixing base, and another straw with a hole in the center was passed through the tip of the insect pin to assemble the straw so that it would rotate. The straw on the rotating side was rubbed with tissue paper to generate a negative charge, and the state when the straw was brought closer was visually observed.
結果
摩擦による静電気を発生させマイナスを帯びたストローに、水を噴霧したストローを接近させても反応はなかった。一方で、処方例２を噴霧したストローを接近させると、固定台に組み立てたストローは吸い寄せられるように回転した。水の場合、電荷を帯びていないため反応しなかったのに対し、処方例２はカチオン化ポリマーを配合するため、噴霧によりプラスの電荷を帯びたストローにマイナスの静電気を帯びたストロー（固定台に組み立てたストロー）が吸い寄せられて回転したことが確認された。
As a result, there was no reaction even when the straw sprayed with water was brought close to the straw that generated static electricity due to friction and had a negative effect. On the other hand, when the straw sprayed with Formulation Example 2 was brought close to the straw, the straw assembled on the fixed base was rotated so as to be attracted. In the case of water, it did not react because it was not charged, whereas in Formulation Example 2, since it contains a cationized polymer, a straw charged with a positive charge by spraying and a straw with a negative static electricity (fixing base). It was confirmed that the straw (assembled in) was attracted and rotated.
（キ）曇り止め効果
試験方法
眼鏡のガラス部分に直接、処方例２を裏表に噴霧（0.15 cc吐出ポンプ：1プッシュ程度ずつ）した後、乾いたティッシュペーパーで拭いた。対象として片方は未塗布とした。沸騰したお湯の上にかざし、曇りの発生状況を目視にて確認した。
(G) Anti-fog effect Test method After spraying Prescription Example 2 directly on the front and back of the glass part of the glasses (0.15 cc discharge pump: about 1 push each), wiped with dry tissue paper. One of the subjects was uncoated. I held it over boiling water and visually confirmed the occurrence of cloudiness.
結果
結果を図５に示す。未塗布のガラスは曇りが発生したが、塗布を行ったガラスは曇りが発生しなかった。
Results The results are shown in FIG. The uncoated glass was fogged, but the coated glass was not fogged.
（ク）消臭効果
試験方法
消臭効果の検証を目的に、臭気のある食品の例としてウオッシュチーズの発酵臭が軽減できるかを官能試験により調べた。具体的にはウオッシュチーズを精製水に10%になるように秤とり懸濁液を調整した。調整した懸濁液の臭気を確認した。その後、調整した懸濁液0.4ｇに処方例２もしくは処方例３を0.3mL噴霧し臭気を確認し、処方例２もしくは処方例３の噴霧前後の臭気を比較した。
(H) Deodorant effect test method For the purpose of verifying the deodorant effect, it was investigated by a sensory test whether the fermented odor of wash cheese could be reduced as an example of odorous food. Specifically, the wash cheese was weighed in purified water to 10% and the suspension was adjusted. The odor of the adjusted suspension was confirmed. Then, 0.3 mL of Formulation Example 2 or Formulation Example 3 was sprayed onto 0.4 g of the prepared suspension to confirm the odor, and the odors before and after spraying of Formulation Example 2 or Formulation Example 3 were compared.
結果
結果を以下の表に示す。4名のパネラーによる官能試験の結果、消臭効果が確認された。
Results The results are shown in the table below. As a result of a sensory test by four panelists, the deodorant effect was confirmed.
処方例４Prescription example 4
※処方例４のポリクオタニウム-64は、特注品（MPC：カチオンモノマー＝45：55）である。 * Polyquaternium-64 in Formulation Example 4 is a custom-made product (MPC: cationic monomer = 45:55).
（ケ）反発効果
試験方法
プラスチック容器に処方例２もしくは処方例４を噴霧して乾燥させた後、ポリスチレンビーズを入れた。比較対象として、プラスチック容器に水を噴霧して乾燥させたものも用意した。さらに、蓋にも同様に噴霧し乾燥させた。ポリスチレンビーズの入った容器を手で強くふって、ポリスチレンビーズにプラスの電荷を発生させ、内部のポリスチレンビーズの様子を目視にて観察した。
(K) Repulsion effect Test method After spraying Formulation Example 2 or Formulation Example 4 on a plastic container and drying it, polystyrene beads were placed. For comparison, we also prepared a plastic container that was sprayed with water and dried. Further, the lid was similarly sprayed and dried. The container containing the polystyrene beads was shaken strongly by hand to generate a positive charge on the polystyrene beads, and the state of the polystyrene beads inside was visually observed.
結果
結果を図６に示す。水を噴霧した方はポリスチレンビーズが容器内側に吸着し、処方例２もしくは処方例４を噴霧した方はポリスチレンビーズが容器内側に吸着していなかった。水噴霧では、プラスの電荷が発生したポリスチレンビーズが、マイナスの電荷をもった容器内側に吸着したが、処方例２もしくは処方例４の塗布により容器内側がプラスの電荷となり吸着しなかったことが確認された。
Results The results are shown in FIG. The polystyrene beads were adsorbed on the inside of the container in the case of spraying water, and the polystyrene beads were not adsorbed on the inside of the container in the person sprayed with Formulation Example 2 or Formulation Example 4. In the water spray, the polystyrene beads that generated a positive charge were adsorbed on the inside of the container with a negative charge, but the inside of the container became a positive charge due to the application of Formulation Example 2 or Formula 4 and did not adsorb. confirmed.
Claims (12)
（ａ）２-メタクリロイルオキシエチルホスホリルコリンと（２-ヒドロキシ-３-メタクリロイルオキシプロピル)トリメチルアンモニウムクロライドからなるカチオン性ポリマー。 Adsorbent and repellent of fine particles containing a liquid composition containing a positively charged substance in which the following component (a) is dissolved or dispersed in water:
(A) A cationic polymer composed of 2-methacryloyloxyethyl phosphorylcholine and (2-hydroxy-3-methacryloyloxypropyl) trimethylammonium chloride.
（ｂ）触媒作用および／または抗菌作用および／または抗ウイルス作用により有害物質を失活させる失活剤；
（ｃ）ポリフェノール系脱臭剤；
（ｄ）眼鏡の曇り止め用の親水性界面活性剤；および
（ｅ）植物の蒸留水を含む賦香剤。 The adsorbent and repellent agent for fine particles according to claim 1, wherein the liquid composition further comprises the following components:
(B) Inactivating agents that inactivate harmful substances by catalytic and / or antibacterial and / or antiviral activity;
(C) Polyphenol deodorant;
(D) Hydrophilic surfactant for anti-fog of eyeglasses; and (e) Perfume agent containing distilled water of plants.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020203082A JP6916560B1 (en) | 2020-12-08 | 2020-12-08 | Fine particle adsorption and repellent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020203082A JP6916560B1 (en) | 2020-12-08 | 2020-12-08 | Fine particle adsorption and repellent |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006002147A (en) * | 2004-05-18 | 2006-01-05 | Shiseido Co Ltd | Pollen adsorption preventive agent |
| EP1815844A2 (en) * | 2005-12-26 | 2007-08-08 | Laboratoires Dermatologiques d'Uriage | Photoprotecting compositions reducing the risk of skin sensitisation |
| US20090018213A1 (en) * | 2006-02-09 | 2009-01-15 | Marcia Snyder | Antiviral method |
| JP2009091269A (en) * | 2007-10-04 | 2009-04-30 | Nakano Seiyaku Kk | Hair cosmetic and composition for hair spray |
| WO2017022829A1 (en) * | 2015-08-05 | 2017-02-09 | 日油株式会社 | Agent for preventing adhesion of dental plaque and stains, and composition for oral use comprising same |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006002147A (en) * | 2004-05-18 | 2006-01-05 | Shiseido Co Ltd | Pollen adsorption preventive agent |
| EP1815844A2 (en) * | 2005-12-26 | 2007-08-08 | Laboratoires Dermatologiques d'Uriage | Photoprotecting compositions reducing the risk of skin sensitisation |
| US20090018213A1 (en) * | 2006-02-09 | 2009-01-15 | Marcia Snyder | Antiviral method |
| JP2009091269A (en) * | 2007-10-04 | 2009-04-30 | Nakano Seiyaku Kk | Hair cosmetic and composition for hair spray |
| WO2017022829A1 (en) * | 2015-08-05 | 2017-02-09 | 日油株式会社 | Agent for preventing adhesion of dental plaque and stains, and composition for oral use comprising same |
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