JP2022061451A - Method for producing cosmetic composition containing micelle complex formed by utilizing natural moisturizing factor, and cosmetic composition produced by the production method - Google Patents
Method for producing cosmetic composition containing micelle complex formed by utilizing natural moisturizing factor, and cosmetic composition produced by the production method Download PDFInfo
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- JP2022061451A JP2022061451A JP2021065610A JP2021065610A JP2022061451A JP 2022061451 A JP2022061451 A JP 2022061451A JP 2021065610 A JP2021065610 A JP 2021065610A JP 2021065610 A JP2021065610 A JP 2021065610A JP 2022061451 A JP2022061451 A JP 2022061451A
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
Abstract
Description
本発明は、天然保湿因子を利用して形成されたミセル複合体を含む化粧料組成物の製造方法、ならびに該製造方法によって製造された化粧料組成物（A method of producing a cosmetic composition comprising a micelle complex formed by using natural moisturizing factor and a cosmetic composition formed by the method）に関するものである。 The present invention relates to a method for producing a cosmetic composition containing a micelle complex formed by utilizing a natural moisturizing factor, and a method of producing a cosmetic composition comprising a micelle. complex formed by using natural moisturizing factor and a cosmetic composition formed by the method).
化粧料組成物で活性を示す有効成分としてビタミン類およびそれらの誘導体、アミノ酸、植物抽出物、香料、酵素、微生物抽出物、ミネラル、などを例として挙げることができ、温度、ｐＨ、光、空気のような外部因子に露出されると、安定性が下がり、これにより、皮膚の吸収率が低下し、化粧品のシワの改善、美白、保湿、紫外線遮蔽などの機能的効果が低下する。 Examples of active ingredients exhibiting activity in cosmetic compositions include vitamins and their derivatives, amino acids, plant extracts, fragrances, enzymes, microbial extracts, minerals, etc., including temperature, pH, light, and air. When exposed to external factors such as, the stability is reduced, which reduces the absorption rate of the skin and reduces the functional effects of cosmetic wrinkle improvement, whitening, moisturizing, UV shielding and the like.
人体の皮膚は、天然保湿因子（Natural Moisturizing Factor、ＮＭＦ）と呼ばれる保湿因子を自ら作成することができる。天然保湿因子は、水に溶ける水溶性低分子であって、アミノ酸が４０％程度を占める。皮膚に存在する天然保湿因子は、周囲の水分を吸収して、表皮と角質層に水分バリアを形成するように助ける物質である。アミノ酸以外の物質としては、汗や皮脂に存在する成分として、代表的には、ミネラル成分が挙げられる。天然保湿因子は、ほとんどの皮膚の内側に存在し、皮膚の外側の保湿を汗と皮脂が担当する。汗と皮脂に存在するミネラル成分は、角質に水分を供給することができる。天然保湿因子は皮膚の弾力、保湿およびシワ防止に重要な役割を果たす物質であり、天然保湿因子が不足すると、皮膚が乾燥し、ひどい場合は、アトピーや極乾燥に皮膚の性質が変更されてしまう恐れもあり、老化が進むにつれて天然保湿因子の皮膚内の含有量が減少し、皮膚の乾燥やシワを誘発する。 The human skin can create a moisturizing factor called Natural Moisturizing Factor (NMF) by itself. The natural moisturizing factor is a water-soluble small molecule that is soluble in water, and amino acids occupy about 40%. Natural moisturizing factors present in the skin are substances that help absorb the surrounding water and form a water barrier in the epidermis and stratum corneum. Examples of substances other than amino acids include mineral components as components present in sweat and sebum. Natural moisturizing factors are present on the inside of most skin, and sweat and sebum are responsible for moisturizing the outside of the skin. The mineral components present in sweat and sebum can supply water to the keratin. Natural moisturizing factors are substances that play an important role in skin elasticity, moisturizing and wrinkle prevention, and lack of natural moisturizing factors can change the properties of the skin to dryness and, in severe cases, atopy and extreme dryness. As the skin ages, the content of natural moisturizing factors in the skin decreases, causing dryness and wrinkles on the skin.
化粧品の開発においては、外部因子から上述した有効成分を保護して安定性を向上させる技術と共に有効成分の溶解度や分散効率を向上させる技術、有効成分を望む部位に効率的に伝える技術、および有効成分の皮膚吸収を促進する技術などの開発が求められ、究極的には有効成分が望まれる部位にて本来の機能を十分に発揮するようにする安定した伝達体の開発が求められる。 In the development of cosmetics, the technology to protect the above-mentioned active ingredient from external factors and improve the stability, the technology to improve the solubility and dispersion efficiency of the active ingredient, the technology to efficiently convey the active ingredient to the desired site, and the effective Development of a technique for promoting skin absorption of the ingredient is required, and ultimately, development of a stable transmitter that fully exerts the original function at the site where the active ingredient is desired is required.
界面活性剤は、油／水の界面と固体／液体の界面のような界面に独特に吸着されるものと知られ、保存において、凝集に対して安定的に残留する液体媒質（例えば、水）の内の粒子の分散物を生成するための安定化剤として使用される。界面にて単分子層としてのこのような吸着特性のために、高分子電解質の形の界面活性剤が固体粒子のような基質にて界面活性剤の層を生成させるために使用された。また、界面活性剤は、単一の凝集物で多数の界面活性剤分子を含有する構造にして凝集することができる。これらの凝集物は、ミセル（micelle）と呼ばれる。このような凝集物は、通常、球の形状を有するが、様々な形状や構造を有することができる。このような凝集物を構成する分子の数は非常に多く、多くの場合、約数百個の分子を数える。ミセルは、比較的に単純な界面活性剤の構造で構成されることがあるが、高分子量のブロック共重合体の界面活性剤で構成されることもある。 Surfactants are known to be uniquely adsorbed to interfaces such as oil / water and solid / liquid interfaces and remain stable against aggregation during storage (eg, water). Used as a stabilizer to form a dispersion of particles within. Due to these adsorption properties as a monomolecular layer at the interface, surfactants in the form of polymer electrolytes have been used to form layers of surfactant on substrates such as solid particles. In addition, the surfactant can be aggregated in a single aggregate having a structure containing a large number of surfactant molecules. These aggregates are called micelles. Such agglomerates usually have the shape of a sphere, but can have a variety of shapes and structures. The number of molecules constituting such aggregates is very large, and in many cases, about several hundred molecules are counted. Micelle may be composed of a relatively simple surfactant structure, but may also be composed of a high molecular weight block copolymer surfactant.
本発明が解決しようとする課題は、天然保湿因子を利用して形成されたミセル複合体を含む化粧料組成物の製造方法及びこれによって製造された化粧料組成物を提供することである。 An object to be solved by the present invention is to provide a method for producing a cosmetic composition containing a micelle complex formed by utilizing a natural moisturizing factor, and a cosmetic composition produced thereby.
前記課題を解決するために、本発明は、ミネラル成分を精製水に投入し、マイクロ波を照射して溶解するステップと、親水性第１アミノ酸を投入して、ミネラル－親水性アミノ酸反応物を製造するステップと、アクリル系ポリマーを投入するステップと、親水性第２アミノ酸を投入して、前記アクリル系ポリマーを中和してクロスリンクを形成し、アクリル系ポリマーとミネラル－アミノ酸反応物を結合するステップと、親水性第３アミノ酸を投入して、第１組成物を製造するステップと、両親媒性溶媒および疎水性アミノ酸を含む第２組成物を製造するステップと、前記第１組成物と前記第２組成物とを混合して、ミセル複合体を含む組成物を製造するステップと、を含む、天然保湿因子を利用して形成されたミセル複合体を含む化粧料組成物の製造方法を提供する。 In order to solve the above-mentioned problems, the present invention comprises a step of adding a mineral component to purified water and irradiating it with a microwave to dissolve it, and adding a hydrophilic first amino acid to prepare a mineral-hydrophilic amino acid reaction product. The step of producing, the step of adding an acrylic polymer, and the step of adding a hydrophilic second amino acid are added to neutralize the acrylic polymer to form a crosslink, and the acrylic polymer and the mineral-amino acid reactant are bound to each other. A step of producing a first composition by adding a hydrophilic third amino acid, a step of producing a second composition containing an amphoteric solvent and a hydrophobic amino acid, and the first composition. A method for producing a cosmetic composition containing a micelle complex formed by utilizing a natural moisturizing factor, which comprises a step of mixing with the second composition to produce a composition containing a micelle complex. offer.
さらに、本発明は、前記製造方法によって製造された天然保湿因子を利用して形成されたミセル複合体を含む化粧料組成物であって、前記ミセルがミネラル－親水性アミノ酸結合体のヘッド部およびアクリル系ポリマーのテール部を含み、前記ミセルの内部には、疎水性アミノ酸が含まれ、ミセル複合体を形成する、天然保湿因子を利用して形成されたミセル複合体を含む化粧料組成物を提供する。 Further, the present invention is a cosmetic composition containing a micelle complex formed by utilizing the natural moisturizing factor produced by the production method, wherein the micelle is a head portion of a mineral-hydrophilic amino acid conjugate and a head portion. A cosmetic composition containing a micelle complex formed by utilizing a natural moisturizing factor, which contains a tail portion of an acrylic polymer and contains a hydrophobic amino acid inside the micelle to form a micelle complex. offer.
本発明による天然保湿因子を利用して形成されたミセル複合体を含む化粧料の製造方法は、マイクロ波を利用することよって製造の初期に電気伝導率を大きくして、機能性物質であるミネラルの溶解度を大幅に向上させることができ、また、ミセル複合体を容易に形成して、疎水性アミノ酸を担持しながらも、高い分散度を確保し、層の分離安定性を確保することができる。 The method for producing a cosmetic containing a micelle complex formed by utilizing a natural moisturizing factor according to the present invention increases the electrical conductivity at the initial stage of production by utilizing microwaves, and is a functional substance, a mineral. It is possible to significantly improve the solubility of the micellar complex, and to easily form a micellar complex to support hydrophobic amino acids, while ensuring a high degree of dispersion and ensuring the separation stability of the layer. ..
また、前記の製造方法によって製造された天然保湿因子を利用して形成されたミセル複合体を含む化粧料組成物は、保湿力とシワの減少に優れた効果を達することができる。 In addition, a cosmetic composition containing a micelle complex formed by utilizing a natural moisturizing factor produced by the above-mentioned production method can achieve an excellent effect of moisturizing power and reducing wrinkles.
以下、本発明の様々な実施例が添付された図面を参照して記載される。本発明は、特定の実施例に限られない。本発明の実施例の様々な変更（Modification）、均等物（Equivalent）および／または代替物（Alternative）を含むものと理解されるべきである。図面の説明に関して、類似の構成要素に対しては類似の参照符号が使用されることもある。 Hereinafter, various embodiments of the present invention will be described with reference to the accompanying drawings. The present invention is not limited to specific examples. It should be understood to include various Modifications, Equivalents and / or Alternatives of the embodiments of the present invention. With respect to the description of the drawings, similar reference numerals may be used for similar components.
本文書において、「有する」、「有することができる」、「含む」、または「含むことができる」などの表現は、当該特徴（例えば、数値、機能、動作、または部品などの構成要素）の存在を示し、追加的な特徴の存在を排除しない。 In this document, expressions such as "have," "can have," "include," or "can include" are components of the feature (eg, numerical values, functions, actions, or components, such as parts). Shows existence and does not rule out the existence of additional features.
本文書において、「ＡまたはＢ」、「Ａおよび／またはＢのうち少なくとも一つ」、または「Ａおよび／またはＢのいずれか、またはそれ以上」などの表現は、提示された項目の可能なすべての組み合わせを含むことができる。例えば、「ＡまたはＢ」、「ＡおよびＢのうち少なくとも一つ」、または「ＡまたはＢのうちの少なくとも一つ」は、（１）少なくとも一つのＡを含む場合、（２）少なくとも一つのＢを含む場合、（３）少なくとも一つのＡと少なくとも一つのＢを含む場合をすべて示すものである。 In this document, expressions such as "A or B", "at least one of A and / or B", or "any or more of A and / or B" are possible of the items presented. All combinations can be included. For example, "A or B", "at least one of A and B", or "at least one of A or B" may (1) include at least one A, (2) at least one. When B is included, (3) all cases including at least one A and at least one B are shown.
本文書において使用された表現、例えば、「～するように構成された（または設定された）（Configured to）」は、状況に応じて、「～に適した（Suitable for）」、「～する能力を有する（Having the capacity to）」、「～するように設計された（Designed to）」、「～するように改造された（Adapted to）」、「～するように造られた（Made to）」、または「～をすることができる（Capable of）」と言い換えて使用することができる。用語「～するように構成（または設定）された」は、「特別に設計されて（Specifically designed to）」いるもののみを意味するものではない。 The expressions used in this document, for example, "Configured to", are "Suitable for" and "to", depending on the situation. "Having the capacity to", "Designed to", "Adapted to", "Made to" ) ”, Or“ Capable of ”can be used in other words. The term "configured (or set) to" does not mean only "specifically designed to".
本文書において使用された用語は、単に特定の実施例を説明するために使用されたものであって、他の実施例の範囲を限定しようとする意図はない。単数の表現は、文脈に沿って明らかに単数を示す意味ではない限り複数の表現を含むことができる。技術的または科学的な用語を含めて。この文書にて使用される用語は、本文書に記載された技術分野で通常の知識を有する者によって一般的に理解されるものと同じ意味を持つことができる。本文書にて使用される用語のうち、一般的な辞書に定義された用語は、関連技術の文脈上持つ意味と同一又は類似な意味で解釈されるべきであり、この文書にて明らかに定義されない限り、理想的または過度に形式的な意味で解釈されない。場合によっては、本文書で定義された用語であっても、本文書の他の実施例を排除するように解釈されてはならない。 The terms used in this document are used solely to describe a particular embodiment and are not intended to limit the scope of other embodiments. A singular expression can include multiple expressions as long as it does not mean that it clearly indicates the singular in context. Including technical or scientific terms. The terms used in this document may have the same meanings as commonly understood by those of ordinary skill in the art described in this document. Of the terms used in this document, those defined in a general dictionary should be construed to have the same or similar meaning in the context of the relevant technology and are clearly defined in this document. Unless done, it will not be interpreted in an ideal or overly formal sense. In some cases, even the terms defined in this document shall not be construed to exclude other embodiments of this document.
本書に開示された実施例は、開示された技術内容の説明と理解のために提示されたものであって、本発明の範囲を限定するものではない。したがって、本文書の範囲は、本発明の技術的思想に基づいたすべての変更や、多様な実施例を含むものと解釈されるべきである。 The examples disclosed in this document are presented for the purpose of explaining and understanding the disclosed technical contents, and do not limit the scope of the present invention. Accordingly, the scope of this document should be construed to include all modifications and various examples based on the technical ideas of the present invention.
以下、本発明の好ましい実施例を詳細に説明する。これに先立ち、本明細書及び請求の範囲にて使用される用語や単語は、通常的意味または辞典的意味に限定して解釈されてはならず、発明者はその自身の発明を最善の方法で説明するために、用語の概念を適切に定義することができる、という原則に立脚して、本発明の技術的思想に符合する意味と概念に解釈されるべきである。 Hereinafter, preferred embodiments of the present invention will be described in detail. Prior to this, the terms and words used herein and in the scope of the claims shall not be construed in a general or lexical sense and the inventor may best use his or her invention. It should be interpreted as a meaning and concept that is consistent with the technical idea of the present invention, based on the principle that the concept of terms can be properly defined.
本明細書に記載された実施例の構成は、本発明の最も好ましい実施例の一部に過ぎないため、本発明の技術的思想をすべて代弁するものではない。したがって、本件の出願時点において、それらを代替することができる多様な均等物と変形例がありうることを理解しなければならない。 The configuration of the examples described herein is only part of the most preferred embodiment of the invention and does not represent all the technical ideas of the invention. Therefore, it must be understood that at the time of filing in this case, there may be various equivalents and variants that can replace them.
この明細書全体において、ある部分がある構成要素を「含む」と記載する場合、別途の反する記載がない限り、他の構成要素を除外するのではなく、他の構成要素をさらに含むことができる意味を有する。 When a component is described as "contains" in the entire specification, the other component may be further included instead of excluding the other component unless otherwise contradictory. It has meaning.
以下では、本発明について具体的に説明する。 Hereinafter, the present invention will be specifically described.
天然保湿因子を利用して形成されたミセル複合体を含む化粧料組成物の製造方法
本発明は、ミネラル成分を精製水に投入し、マイクロ波を照射して溶解するステップと、親水性第１アミノ酸を投入して、ミネラル－親水性アミノ酸反応物を製造するステップと、アクリル系ポリマーを投入するステップと、親水性第２アミノ酸を投入して、前記アクリル系ポリマーを中和してクロスリンクを形成し、アクリル系ポリマーとミネラル－アミノ酸反応物を結合するステップと、親水性第３アミノ酸を投入して、第１組成物を製造するステップと、両親媒性溶媒および疎水性アミノ酸を含む第２組成物を製造するステップと、前記第１組成物と前記第２組成物とを混合して、ミセル複合体を含む組成物を製造するステップとを含むことができる。
Method for Producing Cosmetic Composition Containing Micelle Complex Formed Using Natural Moisturizing Factor The present invention comprises a step of adding a mineral component to purified water and irradiating it with microwaves to dissolve it, and a first hydrophilic property. A step of adding an amino acid to produce a mineral-hydrophilic amino acid reactant, a step of adding an acrylic polymer, and a step of adding a hydrophilic second amino acid to neutralize the acrylic polymer to form a crosslink. A step of forming and binding the acrylic polymer and the mineral-amino acid reactant, a step of adding a hydrophilic third amino acid to prepare the first composition, and a second step containing an amphoteric solvent and a hydrophobic amino acid. A step of producing a composition and a step of mixing the first composition and the second composition to produce a composition containing a micelle complex can be included.
前記ミネラル成分を精製水に投入し、マイクロ波を照射して溶解するステップは、ミネラル成分を精製水に均等に分散させるステップである。該ステップを通じて精製水に分散されたミネラル原子の電子にスピンを形成することができ、これによってミネラル原子の運動性を増加させ、それぞれのミネラル原子の間のギャップを拡張することができる。 The step of putting the mineral component into purified water and irradiating it with microwaves to dissolve it is a step of evenly dispersing the mineral component in purified water. Through this step, spins can be formed on the electrons of the mineral atoms dispersed in purified water, which can increase the motility of the mineral atoms and widen the gap between the respective mineral atoms.
前記ミネラル成分は、塩の形のナトリウム（Ｎａ）と、カルシウム（Ｃａ）と、リン（Ｐ）と、マグネシウム（Ｍｇ）と、カリウム（Ｋ）と、硫黄（Ｓ）と、ゲルマニウム（Ｇｅ）と、亜鉛（Ｚｎ）と、セレン（Ｓｅ）と、これらのいずれかの組み合わせからなる群から選択されるものである。 The mineral components include sodium (Na), calcium (Ca), selenium (P), magnesium (Mg), potassium (K), sulfur (S), and germanium (Ge) in the form of salts. , Zinc (Zn), selenium (Se), and any combination thereof.
高濃度のミネラル成分を含有している物質であれば、本明細書の記載に制限されることなく、これに含まれることができる。高濃度のミネラル成分やミネラル成分を含有する物質は、一つまたは複数のミネラル成分の組み合わせを含むことができる。例えば、前記のミネラル成分は、カルシウム（Ｃａ）やナトリウム（Ｎａ）などの純粋な原子であってもよいし、ＭｇＣｌ２・６Ｈ２Ｏのような水化物であってもよい。または、前記ミネラル成分は、塩の形、例えば、ＮａＣｌ、ＭｇＣｌ２、ＣａＣｌ２などを含むこともでき、また、イオンの形、例えば、Ｎａ＋、Ｍｇ２＋、Ｃａ２＋を含むこともできる。 Any substance containing a high concentration of mineral components can be included without limitation as described herein. A high concentration mineral component or a substance containing a mineral component can contain one or a combination of a plurality of mineral components. For example, the mineral component may be a pure atom such as calcium (Ca) or sodium ( Na), or may be a hydrate such as MgCl 2.6H2O . Alternatively, the mineral component may include salt forms such as NaCl, MgCl 2 , CaCl 2 and the like, and may also include ionic forms such as Na + , Mg 2+ , Ca 2+ .
前記精製水は、当業界にて一般的に使用される精製水、超純水（ultrapure water）を利用することができ、好ましくは超純水を利用する。一般精製水は医薬品、化粧品などに一般的に使用される水であって、純度を示す溶存固形分が１．０～０．５ｐｐｍ、精製水の製造において微粒子と微生物の除去のために使用するフィルタの気孔サイズが０．２～０．４５μｍ、ｐＨが弱酸から弱アルカリまで様々である。前記超純水は、溶存固形分が約０．０３ｐｐｍで純度が非常に高く、超純水の製造において使用されるフィルタの気孔サイズが０．００１μｍであり、これを利用して微生物が９９．９９％除去されたものである。特に、超純水は、金属イオンが除去されるため、組成物の自動酸化反応を防止することができ、また金属イオンによるポリマー凝集現象を防止することができるため、刺激を抑えながらも製剤が均等に塗布されるようにする。 As the purified water, purified water generally used in the art, ultrapure water, can be used, and ultrapure water is preferably used. General purified water is water generally used for pharmaceuticals, cosmetics, etc., and has a dissolved solid content of 1.0 to 0.5 ppm, which indicates purity, and is used for removing fine particles and microorganisms in the production of purified water. The pore size of the filter varies from 0.2 to 0.45 μm, and the pH varies from weak acid to weak alkali. The ultrapure water has a dissolved solid content of about 0.03 ppm and a very high purity, and the pore size of the filter used in the production of ultrapure water is 0.001 μm. It was 99% removed. In particular, ultrapure water can prevent the autoxidation reaction of the composition because metal ions are removed, and can prevent the polymer aggregation phenomenon due to metal ions, so that the formulation can be prepared while suppressing irritation. Make sure it is applied evenly.
本発明者らは例の研究の結果、マイクロ波の照射が水溶液の中のミネラルイオンが電荷を運ぶため、５０℃～８０℃でミネラル成分を精製水に溶解しマイクロ波を３～１０分、好ましくは４～６分照射すると、分子の運動が最も活発になって電気伝導率が大きくなって、分子の間隔が拡大されることを発見した。そこでマイクロ波の周波数は、１，５００～３，０００ＭＨｚである。前記マイクロ波の出力は、５００～１５００Ｗが望ましい。マイクロ波の出力が前記範囲内であることが、ミネラル成分の分散性と組成物の電気伝導率の確保の観点から望ましい。 As a result of the study of the example, the present inventors dissolved the mineral component in purified water at 50 ° C. to 80 ° C. and microwaved for 3 to 10 minutes because the mineral ions in the aqueous solution carry the electric charge when the microwave irradiation was performed. It has been found that when irradiated for preferably 4 to 6 minutes, the movement of the molecules becomes the most active, the electrical conductivity increases, and the spacing between the molecules increases. Therefore, the frequency of the microwave is 1,500 to 3,000 MHz. The output of the microwave is preferably 500 to 1500 W. It is desirable that the microwave output is within the above range from the viewpoint of ensuring the dispersibility of the mineral component and the electrical conductivity of the composition.
組成物に適正の範囲の電気伝導率を備えた方が、この後の工程でミネラル成分と親水性第１アミノ酸との容易な結合に好ましい。具体的には、ミネラル成分の溶解とマイクロ波を照射した後、４０℃で測定した環境で７００～９００μＳ／ｃｍであることが、ミネラル成分の分子運動が最も活発であって、凝集せずに分子間隔を効果的に拡張することができる。 It is preferable that the composition has an electric conductivity in an appropriate range for easy binding between the mineral component and the hydrophilic first amino acid in the subsequent steps. Specifically, the molecular motion of the mineral component is most active and does not aggregate at 700 to 900 μS / cm in an environment measured at 40 ° C. after dissolution of the mineral component and irradiation with microwaves. The molecular spacing can be effectively expanded.
前記親水性第１アミノ酸を投入し、ミネラル－親水性アミノ酸反応物を製造するステップは、後述するミセル形成において、アクリル系ポリマーと結合するための親水性ヘッド部化合物を形成するステップである。 The step of adding the hydrophilic first amino acid to produce a mineral-hydrophilic amino acid reactant is a step of forming a hydrophilic head portion compound for binding to an acrylic polymer in micelle formation described later.
前記親水性第１アミノ酸を投入して、ミネラル－親水性アミノ酸反応物を製造するステップにおいては、３０～５０℃に冷却した後、親水性の第１アミノ酸を投入することが好ましい。ここで組成物の電気伝導率は、４０℃基準８５０～１１００μＳ／ｃｍであることが、アミノ酸と親水性第１アミノ酸の合成を最も効率的に進めることができる。 In the step of adding the hydrophilic first amino acid to produce a mineral-hydrophilic amino acid reaction product, it is preferable to add the hydrophilic first amino acid after cooling to 30 to 50 ° C. Here, when the electric conductivity of the composition is 850 to 1100 μS / cm based on 40 ° C., the synthesis of the amino acid and the hydrophilic first amino acid can be most efficiently promoted.
ここで、前記親水性第１アミノ酸は、セリンとトレオニンのいずれかを含む。 Here, the hydrophilic first amino acid contains either serine or threonine.
前記アクリル系ポリマーを投入するステップは、両親媒性アクリル系ポリマーの親水性残基に、以前のステップで形成されたミネラル－アミノ酸反応物を結合させ、親水性ヘッド部と疎水性テール部を有するアクリル系ポリマーをベース材料として投入するものである。 The step of adding the acrylic polymer binds the mineral-amino acid reactant formed in the previous step to the hydrophilic residue of the amphipathic acrylic polymer, and has a hydrophilic head portion and a hydrophobic tail portion. Acrylic polymer is used as a base material.
前記両親媒性アクリル系ポリマーは、親水性残基と疎水性残基の共重合体であり、例えば、親水性ポリマーの相補的反応部位に反応性末端を有する疎水性残基がグラフト重合（graft polymerization）されたものであってもよい。前記アクリル系ポリマーは、例えば、（メタ）アクリル酸由来の両親媒性ポリマーを使用する。例えば、ポリアクリル酸ナトリウムと、アクリレート／Ｃ１０－３０アルキルアクリレートクロスポリマー（Acrylates/C10-30 Alkyl Acrylate Crosspolymer）と、アクリレート／Ｃ１２－２２アルキルメタクリレート共重合体（Acrylates/C12-22 Alkyl Methacrylate Copolymer）と、アクリレート／べへネス－２５メタクリレート共重合体（Acrylates/Beheneth-25 Methacrylate Copolymer）と、アクリレート／セテス－２０メタクリレート共重合体（Acrylates/Ceteth-20 Methacrylate Copolymer）と、ヒドロキシエチルアクリレート／アクリロイルジメチルタウリンＮａ共重合体（hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer）と、アクリロイルジメチルタウリンアンモニウム／ＶＰ共重合体（Ammonium Acryloyldimethyltaurate/VP Copolymer）と、からなる群から選択される１種以上を含むことができる。 The amphoteric acrylic polymer is a copolymer of a hydrophilic residue and a hydrophobic residue. For example, a hydrophobic residue having a reactive end at a complementary reaction site of the hydrophilic polymer is graft-polymerized (graft). It may be a polymerization). As the acrylic polymer, for example, an amphipathic polymer derived from (meth) acrylic acid is used. For example, sodium polyacrylate, acrylate / C10-30 Alkyl Acrylate Crosspolymer, and acrylate / C12-22 Alkyl Methacrylate Copolymer. , Acrylate / Beheneth-25 Methacrylate Copolymer, Acrylates / Ceteth-20 Methacrylate Copolymer, and hydroxyethyl acrylate / acryloyldimethyltaurine. It can contain one or more selected from the group consisting of Na copolymer (hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer) and Ammonium Acryloyldimethyltaurate / VP Copolymer.
本発明の一実施例によれば、前記アクリル系ポリマーは、ポリアクリル酸ナトリウムとアクリレート／Ｃ１０－３０アルキルアクリレートクロスポリマー（Acrylates/C10-30 Alkyl Acrylate Crosspolymer）を含むことができる。これらはアクリレート／Ｃ１０－３０アルキルアクリレートクロスポリマー（Acrylates/C10-30 Alkyl Acrylate Crosspolymer）を基準にした重量比で１：２０～１：４０で化粧料組成物に含まれることができる。前記の範囲未満であれば、ミセル形成の後、疎水性アミノ酸を内部に容易に担持することができないため、シワのケアの効果が下がり、前記の範囲を超える場合は、適正なｐＨ（弱酸性）の確保が難しく、保湿力が下がりつつ、剤形が不透明になる現象と低温での沈殿の問題とともに、高温では薄い帯の形で分離されるなど、剤形の安定性の側面から好ましくない。 According to one embodiment of the present invention, the acrylic polymer can include sodium polyacrylate and acrylate / C10-30 Alkyl Acrylate Crosspolymer. These can be included in the cosmetic composition at a weight ratio of 1:20 to 1:40 based on the acrylate / C10-30 Alkyl Acrylate Crosspolymer. If it is less than the above range, hydrophobic amino acids cannot be easily carried inside after micelle formation, so that the effect of wrinkle care is reduced, and if it exceeds the above range, an appropriate pH (weakly acidic). ) Is difficult to secure, the moisturizing power decreases, the dosage form becomes opaque, the problem of precipitation at low temperature, and separation in the form of a thin band at high temperature, which is not preferable from the aspect of dosage form stability. ..
また、組成物の温度が４０℃であった場合、アクリル系ポリマーが溶解されたとき、電気伝導率が６００～８５０μＳ／ｃｍであることが剤形の透明度の確保の観点から好ましく、ｐＨは、４～７であることが望ましい。 Further, when the temperature of the composition is 40 ° C., when the acrylic polymer is dissolved, the electric conductivity is preferably 600 to 850 μS / cm from the viewpoint of ensuring the transparency of the dosage form, and the pH is set to. It is preferably 4 to 7.
親水性第２アミノ酸を投入して前記アクリル系ポリマーを中和し、クロスリンクを形成してアクリル系ポリマーとミネラル－アミノ酸反応物を結合するステップは、からんでいるアクリル系ポリマーの構造を乳化し、ポリマーが直鎖状になるように誘導する。アクリル系ポリマーは、精製水によって水和（hydration）された後、親水性の第２アミノ酸によって中和（neutralization）され直鎖状に変形される。 The step of adding a hydrophilic second amino acid to neutralize the acrylic polymer and forming a crosslink to bond the acrylic polymer to the mineral-amino acid reactant emulsifies the structure of the entwined acrylic polymer. , Induces the polymer to be linear. The acrylic polymer is hydrated with purified water and then neutralized with a hydrophilic second amino acid to be linearly deformed.
前記親水性第２アミノ酸は、塩基性アミノ酸であって、リジン、アルギニン、およびヒスチジンからなる群から選択される１種以上を含むことができる。 The hydrophilic second amino acid is a basic amino acid and can include one or more selected from the group consisting of lysine, arginine, and histidine.
親水性第３アミノ酸を投入して、第１組成物を製造するステップは、適正ｐＨの確保及び溶液の安定化のためのバッファーを提供するステップである。前記親水性第３アミノ酸は酸性アミノ酸である。具体的には、グルタミン酸及びアスパラギン酸からなる群から選択される１種以上を含むことができる。 The step of adding the hydrophilic third amino acid to prepare the first composition is a step of providing a buffer for ensuring an appropriate pH and stabilizing the solution. The hydrophilic third amino acid is an acidic amino acid. Specifically, one or more selected from the group consisting of glutamic acid and aspartic acid can be included.
上述した過程を経て形成された第１組成物は、４０℃で電気伝導率が７００～８５０μＳ／ｃｍであって、ｐＨが４．５～６．０で弱酸性であった。このようなｐＨと電気伝導度を確保することにより、本発明の一実施形態に係る化粧料組成物に適用する際に、皮膚に適した弱酸性の剤形を提供することができる。 The first composition formed through the above-mentioned process had an electric conductivity of 700 to 850 μS / cm at 40 ° C. and a weak acidity at a pH of 4.5 to 6.0. By ensuring such pH and electrical conductivity, it is possible to provide a weakly acidic dosage form suitable for the skin when applied to the cosmetic composition according to the embodiment of the present invention.
前記両親媒性溶媒と疎水性アミノ酸とを含む第２組成物を製造するステップは、天然保湿因子を利用して形成されたミセル複合体を含む化粧料組成物のための２液型ステップである。このステップは、別途の容器に両親媒性溶媒と疎水性アミノ酸を溶解して、ミセル複合体の形成の際に、疎水性アミノ酸がミセルの内部に容易に含まれるようにするための段階である。前記第２組成物は、必要に応じて精製水をさらに含んでいてもよい。 The step of producing the second composition containing the amphipathic solvent and the hydrophobic amino acid is a two-component step for a cosmetic composition containing a micelle complex formed by utilizing a natural moisturizing factor. .. This step is to dissolve the amphipathic solvent and hydrophobic amino acids in a separate container so that the hydrophobic amino acids are easily contained inside the micelles during the formation of the micelle complex. .. The second composition may further contain purified water, if necessary.
前記両親媒性溶媒は、グリセリン（Glycerin）と、ジプロピレングリコール（Dipropylene Glycol）と、メチルプロパンジオール（Methyl Propanediol）と、プロピレングリコール（Propylene Glycol）と、ブチレングリコール（Butylene Glycol）と、からなる群から選択される１種以上を含むことができる。 The amphoteric solvent is a group consisting of glycerin, dipropylene Glycol, Methyl Propanediol, Propylene Glycol, and Butylene Glycol. Can include one or more selected from.
前記疎水性アミノ酸は、グリシンと、ロイシンと、メチオニンと、バリンと、アラニンと、イソロイシンと、トリプトファンと、フェニルアラニンと、プロリンと、からなる群から選択される１種以上を含むことができる。 The hydrophobic amino acid can include one or more selected from the group consisting of glycine, leucine, methionine, valine, alanine, isoleucine, tryptophan, phenylalanine, and proline.
第１組成物及び第２組成物を混合して、ミセル複合体を含む組成物を製造するステップは、２液型反応である。前記ステップは、好ましくは、前記第１組成物と第２組成物を重量比１：０．１５～１：０．３５の割合で２液型に製造するステップである。 The step of mixing the first composition and the second composition to produce a composition containing a micelle complex is a two-component reaction. The step is preferably a step of producing the first composition and the second composition in a two-component form at a weight ratio of 1: 0.15 to 1: 0.35.
前記の範囲未満であれは、油中水（Ｗ／Ｏ、Water In Oil）型でありながらアクリル系ポリマーが投入されるため、具体的にはＷ／Ｐ型（Water in Polymer）の剤型で水分（精製水）をバインディングしている構造を有するために、疎水性の部分（Polymer）が不足して、ミセルが不十分に形成されるか、または形成されないこともあり得る。前記の範囲を超える場合には、層が分離してしまう現象が生じる可能性があり、最終的な化粧料組成物の透明度が劣ってしまう恐れがある。 If it is less than the above range, an acrylic polymer is charged even though it is a water in oil type, so specifically, it is a W / P type (Water in Polymer) type. Due to the structure binding the water (purified water), the hydrophobic moiety (Polymer) may be deficient and the micelles may or may not be formed inadequately. If it exceeds the above range, a phenomenon that the layers are separated may occur, and the transparency of the final cosmetic composition may be deteriorated.
本発明のミセル複合体を含む化粧料組成物の構成成分のそれぞれの含有量は、以下の通りである。含有量の基準に関しては、第１組成物及び第２組成物のそれぞれを基準とする。それぞれの構成成分は、下記の含有量の範囲内で溶媒に投入されて溶解される。 The contents of each of the constituents of the cosmetic composition containing the micelle complex of the present invention are as follows. Regarding the standard of content, each of the first composition and the second composition is used as a standard. Each component is charged into a solvent and dissolved within the range of the following contents.
第１組成物において、精製水１００重量部を基準にして、ミネラル成分が０．０１～０．０５重量部、親水性第１アミノ酸が０．００５～０．０１５重量部、アクリル系ポリマーが０．０１～０．１５重量部、親水性第２アミノ酸が０．００１～０．０１０重量部、及び親水性第３アミノ酸が０．００５～０．０１５重量部含まれることができる。 In the first composition, based on 100 parts by weight of purified water, the mineral component is 0.01 to 0.05 parts by weight, the hydrophilic first amino acid is 0.005 to 0.015 parts by weight, and the acrylic polymer is 0. It can contain 0.01 to 0.15 parts by weight, 0.001 to 0.010 parts by weight of the hydrophilic second amino acid, and 0.005 to 0.015 parts by weight of the hydrophilic third amino acid.
ミネラル成分は、前記含有量の範囲未満である場合、ミセル複合体の親水性ヘッド部が容易に形成されないため、好ましくない。前記含有量の範囲を超える場合、ミネラル成分によるポリマーのクロスリンクを低下させ、時間の経過につれて剤形の粘度の低下や透明性に影響を与える恐れがある。また、所定の値以上の含有量のミネラル成分は、浸透現象によって水分を皮膚の内部に供給するより外部へ流出させるため、乾燥感を極大化させる恐れがある。 If the content of the mineral component is less than the above range, the hydrophilic head portion of the micelle complex is not easily formed, which is not preferable. If the content exceeds the above range, the cross-linking of the polymer due to the mineral component may be reduced, which may affect the decrease in the viscosity of the dosage form and the transparency over time. In addition, a mineral component having a content of a predetermined value or more causes water to flow out rather than being supplied to the inside of the skin due to an osmotic phenomenon, which may maximize the feeling of dryness.
親水性第１アミノ酸は、前記含有量の範囲未満である場合、ミセル複合体の親水性ヘッド部が容易に形成されないため好ましくない。前記含有量の範囲を超える場合、親水性ヘッド部の大きさが過度に大きくなってしまい、水分バインディング力は増加するが、表面張力、すなわち親水性アミノ酸の界面の張力が大きくなって、親水性アミノ酸同士に凝集する傾向が現れ、剤形の安定性の側面から好ましくない。 When the content of the first hydrophilic amino acid is less than the above range, the hydrophilic head portion of the micellar complex is not easily formed, which is not preferable. When the content exceeds the above range, the size of the hydrophilic head portion becomes excessively large and the water binding force increases, but the surface tension, that is, the tension at the interface of the hydrophilic amino acid increases, and the hydrophilicity becomes hydrophilic. There is a tendency for amino acids to aggregate with each other, which is not preferable from the viewpoint of stability of the dosage form.
アクリル系ポリマーは、前記含有量の範囲未満である場合、粘度と含有量が低いためミセル複合体を形成することができない。また疎水性アミノ酸をミセルの内部に担持し難い側面から好ましくない。前記含有量の範囲を超える場合、剤形がぬるぬるになってしまい、吸水性が悪く、透明度に影響を与えることもある。 If the content of the acrylic polymer is less than the above range, the viscosity and content of the acrylic polymer are low, so that the micellar complex cannot be formed. Further, it is not preferable because it is difficult to support hydrophobic amino acids inside the micelle. If the content exceeds the range, the dosage form becomes slimy, the water absorption is poor, and the transparency may be affected.
親水性第２アミノ酸は、前記含有量の範囲未満である場合、アクリル系ポリオールの中和作用が不十分に生じて、クロスリンクを形成することができず分散力が低下し、ミセル複合体の形成に悪影響を与える恐れがある。前記含有量の範囲を超える場合、ｐＨ上昇の影響によって、皮膚のバリアを弱化させ、水分の損失をもたらすとともに皮膚の乾燥を悪化させ、皮膚に刺激を与える観点から望ましくない。 When the content of the hydrophilic second amino acid is less than the above range, the neutralizing action of the acrylic polyol is insufficient, the cross-link cannot be formed, the dispersion force is lowered, and the micellar complex is formed. May adversely affect formation. If the content exceeds the above range, it is not desirable from the viewpoint of weakening the barrier of the skin, causing the loss of water, worsening the dryness of the skin, and irritating the skin due to the influence of the increase in pH.
親水性第３アミノ酸は、前記含有量の範囲未満である場合、化粧料組成物の剤形の安定性を確保するのに影響を及ぼす。また、ｐＨを弱酸性に調整させ難くなり、本願発明の固有の効果である保湿力の向上やシワの改善の効果が低下してしまう側面から好ましくない。前記含有量の範囲を超える場合、ｐＨが低くなり、安定度や剤形的側面から好ましくない。 When the content of the hydrophilic third amino acid is less than the above range, it affects to ensure the stability of the dosage form of the cosmetic composition. Further, it becomes difficult to adjust the pH to weak acidity, which is not preferable from the viewpoint that the effect of improving the moisturizing power and the effect of improving wrinkles, which are the inherent effects of the present invention, is reduced. If the content exceeds the above range, the pH becomes low, which is not preferable from the viewpoint of stability and dosage form.
第２組成物において、両親媒性溶媒１００重量部を基準にして、疎水性アミノ酸が０．０１～０．１０重量部、精製水が２０～５０重量部含まれることができる。 The second composition may contain 0.01 to 0.10 parts by weight of hydrophobic amino acids and 20 to 50 parts by weight of purified water based on 100 parts by weight of the amphipathic solvent.
疎水性アミノ酸は、前記含有量の範囲未満である場合、ミセル複合体の内部に担持される疎水性アミノ酸の総量が減少し、本願発明の固有の効果である保湿力、シワの改善の効果が低下してしまう側面から好ましくない。前記含有量の範囲を超える場合、ポリマーがサスペンディングすることができる範囲を超えると、層の分離が生じる可能性があるので、剤形の安定性の側面から好ましくない。 When the content of the hydrophobic amino acid is less than the above range, the total amount of the hydrophobic amino acid carried inside the micelle complex is reduced, and the moisturizing power and the effect of improving wrinkles, which are the inherent effects of the present invention, are obtained. It is not preferable from the aspect of lowering. If the content exceeds the range in which the polymer can be suspended, layer separation may occur, which is not preferable from the viewpoint of dosage form stability.
天然保湿因子を利用して形成されたミセル複合体を含む化粧料組成物
上述したような天然保湿因子を用いて形成されたミセルは、ミネラル－親水性アミノ酸結合体を含むヘッド部と、アクリル系ポリマーを含むテール部を含む。前記ミセル内部には疎水性アミノ酸が含まれている。ミセル複合体は、前記ミセルと該ミセルの内部に含まれている疎水性アミノ酸を含むものであり、精製水を溶媒とする化粧料組成物に前記ミセル複合体が適宜に分散される。
Cosmetic Composition Containing Micelle Complex Formed Using Natural Moisturizing Factor The micelles formed using the natural moisturizing factor as described above have a head portion containing a mineral-hydrophilic amino acid conjugate and an acrylic type. Includes tail containing polymer. Hydrophobic amino acids are contained inside the micelles. The micelle complex contains the micelle and the hydrophobic amino acid contained in the micelle, and the micelle complex is appropriately dispersed in a cosmetic composition using purified water as a solvent.
特に、前記疎水性アミノ酸は、グリシンと、ロイシンと、メチオニンと、バリンと、アラニンと、イソロイシンと、トリプトファンと、フェニルアラニンと、プロリンからなる群から選択される１種以上を含むことができる。 In particular, the hydrophobic amino acid can include one or more selected from the group consisting of glycine, leucine, methionine, valine, alanine, isoleucine, tryptophan, phenylalanine, and proline.
前記ミセル複合体は、組成物１００重量％のうち０．０１～０．０５重量％含まれることができる。前記ミセル複合体が前記の範囲で化粧料組成物に含まれることによって、皮膚に適用する際、ミセル内部の疎水性アミノ酸が角質層の角質細胞内の細胞間脂質を支え、皮膚の水分と結合する。これによって皮膚の水分を保持し、水分の蒸発を防止する役割を効果的に果たすことができる。かつ、層の分離に関する安定性と剤形の透明度を確保することができる。 The micelle complex can be contained in an amount of 0.01 to 0.05% by weight based on 100% by weight of the composition. By including the micelle complex in the cosmetic composition in the above range, when applied to the skin, the hydrophobic amino acids inside the micelle support the intercellular lipids in the stratum corneum of the stratum corneum and bind to the water of the skin. do. As a result, it is possible to effectively retain the moisture of the skin and prevent the evaporation of the moisture. In addition, stability regarding layer separation and transparency of the dosage form can be ensured.
前記ミセル複合体が含まれている化粧料組成物は、本発明の上述した効果であるシワの緩和と皮膚の保湿力の確保の観点から、組成物の温度が４０℃である場合、電気伝導率が７５０～８５０μＳ／ｃｍであって、ｐＨが５．０～６．０であることが望ましい
本発明の一実施形態に係る化粧料組成物は、油中水（Ｗ／Ｏ）型である。具体的にはアクリル系ポリマーを用いることにより、オイル（Oil）成分は、ポリマー（Polymer）を含むことができる。したがって、本発明者らは、これをＷ／Ｐ（Water In Polymer）型と示す。これを満足する剤形であれば制限なく利用することができる。例えば、基礎化粧料の剤形、スキン、ローション、アイクリーム、スーディングジェル、軟膏、マスクパック用製剤、ボディウォッシュ用製剤、ピーリングゲル（peeling gel）、水中油型のメイクアップベース、油中水型メイクアップベース、ファンデーション、スキンカバー、口紅、リップグロス、フェイスパウダー（face powder）、ツーウェイケーキパウダー（2-way cake powder）、アイシャドー（eye shadow）、チークカラーアイブロウペンシル（chic color eyebrow pencil）類からなる色調化粧料製剤、日焼け止め、ＢＢクリーム、および頭皮用製剤のうちから選択されるいずれか一つであってもよい。
The cosmetic composition containing the micelle complex is electrically conducted when the temperature of the composition is 40 ° C. from the viewpoint of alleviating wrinkles and ensuring the moisturizing power of the skin, which are the above-mentioned effects of the present invention. The cosmetic composition according to one embodiment of the present invention, which preferably has a ratio of 750 to 850 μS / cm and a pH of 5.0 to 6.0, is a water-in-oil (W / O) type. .. Specifically, by using an acrylic polymer, the oil component can include a polymer. Therefore, the present inventors refer to this as a W / P (Water In Polymer) type. Any dosage form that satisfies this can be used without limitation. For example, basic cosmetic formulations, skins, lotions, eye creams, soothing gels, ointments, mask pack formulations, body wash formulations, peeling gels, oil-in-water make-up bases, water in oil. Mold make-up base, foundation, skin cover, lipstick, lip gloss, face powder, 2-way cake powder, eye shadow, chic color eyebrow pencil It may be any one selected from a color cosmetic preparation consisting of the same kind, a sunscreen, a BB cream, and a preparation for the scalp.
以下、実施例を通じて本発明をさらに詳細に説明する。これらの実施例は、本発明をより具体的に説明するためのものであり、本発明の範囲がこれらの実施例によって制限されないということは、本発明が属する技術分野で通常の知識を有する者において明らかである。 Hereinafter, the present invention will be described in more detail through examples. These examples are for more specific explanation of the present invention, and the fact that the scope of the present invention is not limited by these examples is a person who has ordinary knowledge in the technical field to which the present invention belongs. It is clear in.
製造例
製造例１
第１組成物として、７５℃の精製水０．５ｇにＮａＣｌ０．０２５ｇと、ＭｇＣｌ２０．０００２５ｇと、ＣａＣｌ２０．０００２ｇとを混合した後、ＣＥＭ社アメリカ製マイクロ波機器を用いてマイクロ波を２，４００～２，５００ＭＨｚ、１０００Ｗで１５分間照射した（Ｓ１）。前記組成物を４０℃に冷却した後、精製水０．５ｇと、セリン０．００５ｇと、トレオニン０．００１５ｇとを投入して、ミネラル成分と反応させた（Ｓ２）。その後、精製水７４ｇと、ポリアクリル酸ナトリウム０．０４５ｇと、アクリレート／Ｃ１０－３０アルキルアクリレートクロスポリマー（Acrylates/C10-30 Alkyl Acrylate Crosspolymer）０．００１７ｇとを混合した後、容器に投入した（Ｓ３）。精製水０．５ｇと、アルギニン０．００１３ｇと、ヒスチジン０．００５ｇとを混合した後、容器に投入した（Ｓ４）。精製水５ｇと、グルタミン酸０．００６ｇと、アスパラギン酸０．００３ｇとを混合した後、容器に投入した（Ｓ５）。
Manufacturing example
Production Example 1
As the first composition, 0.025 g of NaCl, 0.00025 g of MgCl 2 and 0.0002 g of CaCl 2 were mixed with 0.5 g of purified water at 75 ° C., and then microwaves were used using a microwave device manufactured by CEM. Was irradiated at 2,400 to 2,500 MHz and 1000 W for 15 minutes (S1). After cooling the composition to 40 ° C., 0.5 g of purified water, 0.005 g of serine and 0.0015 g of threonine were added and reacted with the mineral component (S2). Then, 74 g of purified water, 0.045 g of sodium polyacrylate, and 0.0017 g of acrylate / C10-30 Alkyl Acrylate Crosspolymer were mixed and then put into a container (S3). ). After mixing 0.5 g of purified water, 0.0013 g of arginine, and 0.005 g of histidine, the mixture was placed in a container (S4). After mixing 5 g of purified water, 0.006 g of glutamic acid, and 0.003 g of aspartic acid, the mixture was placed in a container (S5).
第２組成物として、別途の容器に、グリセリン１４ｇと、アラニン０．００１５ｇと、プロリン０．００１４ｇと、グリシン０．００９ｇと、精製水５ｇとを混合した（Ｓ６）。 As the second composition, 14 g of glycerin, 0.0015 g of alanine, 0.0014 g of proline, 0.009 g of glycine, and 5 g of purified water were mixed in a separate container (S6).
その後、前記第１組成物及び前記第２組成物を混合して最終的な組成物を製造した（Ｓ７）。 Then, the first composition and the second composition were mixed to produce a final composition (S7).
製造例２
７５℃の精製水０．５ｇにＮａＣｌ０．０２５ｇと、ＭｇＣｌ２０．０００２５ｇと、ＣａＣｌ２０．０００２ｇとを混合した後、ＣＥＭ社アメリカ製マイクロ波機器を用いてマイクロ波を２，４００～２，５００ＭＨｚ、１０００Ｗの出力で１５分間照射した（Ｓ１＊）。前記組成物を４０℃に冷却した後、精製水０．５ｇと、セリン０．００５ｇと、トレオニン０．００１５ｇとを投入して、ミネラル成分と反応させた（Ｓ２＊）。その後、精製水７４ｇと、ポリアクリル酸ナトリウム０．０４５ｇと、アクリレート／Ｃ１０－３０アルキルアクリレートクロスポリマー（Acrylates/C10-30 Alkyl Acrylate Crosspolymer）０．００１７ｇとを混合した後、容器に投入した（Ｓ３＊）。精製水０．５ｇと、アルギニン０．００１３ｇと、ヒスチジン０．００５ｇとを混合した後、容器に投入した（Ｓ４＊）。精製水５ｇと、グルタミン酸０．００６ｇと、アスパラギン酸０．００３ｇとを混合した後、容器に投入した（Ｓ５＊）。グリセリン１４ｇと、アラニン０．００１５ｇと、プロリン０．００１４ｇと、グリシン０．００９ｇと、精製水５ｇとを混合した後、容器に投入して、最終的な組成物を製造した（Ｓ６＊）。
Manufacturing example 2
After mixing 0.025 g of NaCl, 0.00025 g of MgCl 2 and 0.0002 g of CaCl in 0.5 g of purified water at 75 ° C., microwaves are generated from 2,400 to 2 using a microwave device manufactured by CEM. Irradiation was performed for 15 minutes at an output of 500 MHz and 1000 W (S1 *). After cooling the composition to 40 ° C., 0.5 g of purified water, 0.005 g of serine and 0.0015 g of threonine were added and reacted with the mineral component (S2 *). Then, 74 g of purified water, 0.045 g of sodium polyacrylate, and 0.0017 g of acrylate / C10-30 Alkyl Acrylate Crosspolymer were mixed and then put into a container (S3). *). After mixing 0.5 g of purified water, 0.0013 g of arginine, and 0.005 g of histidine, the mixture was placed in a container (S4 *). After mixing 5 g of purified water, 0.006 g of glutamic acid, and 0.003 g of aspartic acid, the mixture was placed in a container (S5 *). After mixing 14 g of glycerin, 0.0015 g of alanine, 0.0014 g of proline, 0.009 g of glycine, and 5 g of purified water, they were put into a container to prepare a final composition (S6 *).
製造例３
第１組成物として、７５℃の精製水０．５ｇにＮａＣｌ０．０２５ｇと、ＭｇＣｌ２０．０００２５ｇと、ＣａＣｌ２０．０００２ｇとを混合した後、ＣＥＭ社アメリカ製マイクロ波機器を用いてマイクロ波を２，４００～２，５００ＭＨｚ、１０００Ｗの出力で１５分間照射した（Ｓ１＊＊）。前記組成物を４０℃に冷却した後、精製水０．５ｇと、セリン０．００５ｇと、トレオニン０．００１５ｇとを投入して、ミネラル成分と反応させた（Ｓ２＊＊）。その後、精製水７４ｇと、ヒドロキシエチルセルロース（Hydroxy-ethylcellulose）０．０５６ｇとを混合した後、容器に投入した（Ｓ３＊＊）。精製水０．５ｇと、アルギニン０．００１３ｇと、ヒスチジン０．００５ｇとを混合した後、容器に投入した（Ｓ４＊＊）。精製水５ｇと、グルタミン酸０．００６ｇと、アスパラギン酸０．００３ｇとを混合した後、容器に投入した（Ｓ５＊＊）。
Production example 3
As the first composition, 0.025 g of NaCl, 0.00025 g of MgCl 2 and 0.0002 g of CaCl 2 were mixed with 0.5 g of purified water at 75 ° C., and then microwaves were used using a microwave device manufactured by CEM. Was irradiated for 15 minutes at an output of 2,400 to 2,500 MHz and 1000 W (S1 **). After cooling the composition to 40 ° C., 0.5 g of purified water, 0.005 g of serine and 0.0015 g of threonine were added and reacted with a mineral component (S2 **). Then, 74 g of purified water and 0.056 g of hydroxyethylcellulose were mixed and then put into a container (S3 **). After mixing 0.5 g of purified water, 0.0013 g of arginine, and 0.005 g of histidine, the mixture was placed in a container (S4 **). After mixing 5 g of purified water, 0.006 g of glutamic acid, and 0.003 g of aspartic acid, the mixture was placed in a container (S5 **).
第２組成物として、別途の容器に、グリセリン１４ｇと、アラニン０．００１５ｇと、プロリン０．００１４ｇと、グリシン０．００９ｇと、精製水５ｇとを混合した（Ｓ６＊＊）。 As the second composition, 14 g of glycerin, 0.0015 g of alanine, 0.0014 g of proline, 0.009 g of glycine, and 5 g of purified water were mixed in a separate container (S6 **).
その後、前記第１組成物及び第２組成物を混合して、最終的な組成物を製造した（Ｓ７＊＊）。 Then, the first composition and the second composition were mixed to produce a final composition (S7 **).
製造例４
第１組成物として、７５℃の精製水０．５ｇにＮａＣｌ０．０２５ｇと、ＭｇＣｌ２０．０００２５ｇと、ＣａＣｌ２０．０００２ｇとを混合した（Ｓ１＊＊＊）。前記組成物を４０℃に冷却した後、精製水０．５ｇと、セリン０．００５ｇと、トレオニン０．００１５ｇとを投入して、ミネラル成分と反応させた（Ｓ２＊＊＊）。その後、精製水７４ｇと、ポリアクリル酸ナトリウム０．０４５ｇと、アクリレート／Ｃ１０－３０アルキルアクリレートクロスポリマー（Acrylates/C10-30 Alkyl Acrylate Crosspolymer）０．００１７ｇとを混合した後、容器に投入した（Ｓ３＊＊＊）。精製水０．５ｇと、アルギニン０．００１３ｇと、ヒスチジン０．００５ｇとを混合した後、容器に投入した（Ｓ４＊＊＊）。精製水５ｇと、グルタミン酸０．００６ｇと、アスパラギン酸０．００３ｇとを混合した後、容器に投入した（Ｓ５＊＊＊）。
Production example 4
As the first composition, 0.025 g of NaCl, 0.00025 g of MgCl 2 and 0.0002 g of CaCl 2 were mixed with 0.5 g of purified water at 75 ° C. (S1 ***). After cooling the composition to 40 ° C., 0.5 g of purified water, 0.005 g of serine and 0.0015 g of threonine were added and reacted with a mineral component (S2 ***). Then, 74 g of purified water, 0.045 g of sodium polyacrylate, and 0.0017 g of acrylate / C10-30 Alkyl Acrylate Crosspolymer were mixed and then put into a container (S3). ***). After mixing 0.5 g of purified water, 0.0013 g of arginine, and 0.005 g of histidine, the mixture was placed in a container (S4 ***). After mixing 5 g of purified water, 0.006 g of glutamic acid, and 0.003 g of aspartic acid, the mixture was placed in a container (S5 ***).
第２組成物として、別途の容器に、グリセリン１４ｇと、アラニン０．００１５ｇと、プロリン０．００１４ｇと、グリシン０．００９ｇと、精製水５ｇとを混合した（Ｓ６＊＊＊）。 As the second composition, 14 g of glycerin, 0.0015 g of alanine, 0.0014 g of proline, 0.009 g of glycine, and 5 g of purified water were mixed in a separate container (S6 ***).
その後、前記第１組成物及び第２組成物を混合して、最終的な組成物を製造した（Ｓ７＊＊＊）。 Then, the first composition and the second composition were mixed to produce a final composition (S7 ***).
実施例と比較例
実施例１
製造例１の工程によって製造された化粧料組成物を実施例１にした。
Examples and Comparative Examples
Example 1
The cosmetic composition produced by the process of Production Example 1 was designated as Example 1.
実施例２～７
製造例１の工程と同様に製造する。ただし、構成成分の含有量を下記のように調整して製造した化粧料組成物を実施例２～７にした。
Examples 2-7
It is manufactured in the same manner as in the process of Production Example 1. However, the cosmetic compositions produced by adjusting the content of the constituent components as described below were used in Examples 2 to 7.
比較例１
製造例２の工程によって製造された化粧料組成物を比較例１にした。
Comparative Example 1
The cosmetic composition produced by the process of Production Example 2 was designated as Comparative Example 1.
比較例２
製造例３の工程によって製造された化粧料組成物を比較例２にした。
Comparative Example 2
The cosmetic composition produced by the process of Production Example 3 was designated as Comparative Example 2.
比較例３
製造例４の工程によって製造された化粧料組成物を比較例３にした。
Comparative Example 3
The cosmetic composition produced by the process of Production Example 4 was designated as Comparative Example 3.
実験例１：各ステップごとの温度とｐＨ確認
製造例１～製造例４の各製造ステップでの温度、ｐＨ、電気伝導率を下表のように測定した。電気伝導率の場合METTER TOLEDO社Cond probe InLab 720製品を用いた。（「－」の表記は、測定していないことを示す。）
Experimental Example 1: Checking the temperature and pH in each step The temperature, pH, and electrical conductivity in each of the manufacturing steps of Production Examples 1 to 4 were measured as shown in the table below. For electrical conductivity, METTER TOLEDO Cond probe InLab 720 product was used. (The notation of "-" indicates that the measurement has not been performed.)
実験例２：皮膚水分の増加
発明者らは、皮膚が良くない２０～４０歳の女性５０人を選定し、前記実施例及び比較例によって製造された化粧料組成物を、毎日２回１ヶ月間、顔や首などに塗布するようにした。塗布の開始に前もって恒温、恒湿条件（２４℃、湿度４０％）を満たした環境で水分測定器（Corneometer、CM820 courage Khazaka electronic GmbH、Germany）を用いて皮膚の乾燥度を測定して基本値とみなした。それぞれ１週目、２週目、４週目の経過後の皮膚の保湿量を測定して客観的な効果を評価した。その結果を［表３］に示した。
Experimental Example 2: Increase in skin moisture The inventors selected 50 women aged 20 to 40 years with poor skin, and applied the cosmetic composition produced by the above Examples and Comparative Examples twice daily for 1 month. I applied it to my face and neck for a while. The basic value is measured by measuring the dryness of the skin using a moisture measuring device (Corneometer, CM820 courage Khazaka electronic GmbH, Germany) in an environment where constant temperature and humidity conditions (24 ° C, humidity 40%) are satisfied prior to the start of application. I regarded it as. The moisturizing amount of the skin after the first week, the second week, and the fourth week, respectively, was measured to evaluate the objective effect. The results are shown in [Table 3].
実験例３：製造後の経時安定性を観察（層分離安定性を観察）
前記実施例及び比較例によって製造された組成物を、常温条件で１２ヶ月以上の間、４５℃の高温条件で１ヶ月以上の間、－４℃の低温条件で１ヶ月以上の間、それぞれの環境に露出し、経時安定性を観察した。その結果を［表４］に示した。
Experimental Example 3: Observe the stability over time after production (observe the layer separation stability)
The compositions produced by the above Examples and Comparative Examples were used for 12 months or more under normal temperature conditions, 1 month or more under high temperature conditions of 45 ° C., and 1 month or more under low temperature conditions of -4 ° C., respectively. It was exposed to the environment and its stability over time was observed. The results are shown in [Table 4].
○：良好（外観変化なし、透明）、△：変化あり（外観が不透明）、×：不良（層の分離が発生） ○: Good (no change in appearance, transparent), △: Change (opaque appearance), ×: Poor (separation of layers occurs)
実験例４：シワ改善の測定
常温、湿度４０～６０％の恒温・恒湿条件にて、健康な２５～５５歳の女性２０人（平均年齢：４０．３０歳）を選定し、毎実験日ごとに、被験者が実施例の化粧料組成物を使用するその直前に、目元のしわと皮膚粘弾性測定（Cutometer MPA 580（C + K、Germany））を行った。その結果を［表５］に示した。
Experimental example 4: Measurement of wrinkle improvement Twenty healthy women aged 25 to 55 years (average age: 40.30 years) were selected under constant temperature and humidity conditions of room temperature and humidity of 40 to 60%, and each experiment day. For each subject, wrinkles around the eyes and skin viscoelasticity measurements (Cutometer MPA 580 (C + K, Germany)) were performed immediately prior to the subject's use of the cosmetic composition of the example. The results are shown in [Table 5].
皮膚粘弾性値＝皮膚の変化パターン領域（Ｕｖ）／皮膚回復パターン領域（Ｕｅ）
皮膚粘弾性値が低いほど弾性が優れたものである。
Skin viscoelasticity value = skin change pattern region (Uv) / skin recovery pattern region (Ue)
The lower the skin viscoelasticity value, the better the elasticity.
被験者１人を選定し、シワ測定撮影装置（aram ASM-300）を用いて、本発明の実施例１に係る化粧料組成物の使用前と使用後（４週間後の時点）の目元のシワを撮影した。その結果を図１に示した。使用後のシワの面積が減少したことからシワが有意義に改善されたことがわかる。 One subject was selected, and wrinkles around the eyes were used before and after the use of the cosmetic composition according to Example 1 of the present invention (at the time after 4 weeks) using a wrinkle measurement imaging device (aram ASM-300). Was taken. The results are shown in FIG. Since the area of wrinkles after use decreased, it can be seen that the wrinkles were significantly improved.
Claims (8)
親水性第１アミノ酸を投入して、ミネラル－親水性アミノ酸反応物を製造するステップと；
アクリル系ポリマーを投入するステップと；
親水性第２アミノ酸を投入して、前記アクリル系ポリマーを中和してクロスリンクを形成し、アクリル系ポリマーとミネラル－アミノ酸反応物を結合するステップと；
親水性第３アミノ酸を投入して、第１組成物を製造するステップと；
両親媒性溶媒および疎水性アミノ酸を含む第２組成物を製造するステップと；
前記第１組成物と前記第２組成物とを混合して、ミセル複合体を含む組成物を製造するステップ；と
を含む、天然保湿因子を利用して形成されたミセル複合体を含む化粧料組成物の製造方法。 The step of putting the mineral component into purified water and irradiating it with microwaves to dissolve it;
With the step of adding a hydrophilic first amino acid to produce a mineral-hydrophilic amino acid reactant;
With the step of adding an acrylic polymer;
With the step of adding a hydrophilic second amino acid to neutralize the acrylic polymer to form a crosslink and binding the acrylic polymer to the mineral-amino acid reactant;
With the step of preparing the first composition by adding the hydrophilic third amino acid;
With the steps of making a second composition comprising an amphipathic solvent and a hydrophobic amino acid;
A cosmetic comprising a micelle complex formed using a natural moisturizing factor, comprising the step of mixing the first composition and the second composition to produce a composition comprising a micelle complex; Method for producing the composition.
前記ミセルがミネラル－親水性アミノ酸結合体のヘッド部およびアクリル系ポリマーのテール部を含み、
前記ミセルの内部には、疎水性アミノ酸が含まれ、ミセル複合体を形成する、化粧料組成物。 A cosmetic composition containing a micelle complex produced by the production method according to any one of claims 1 to 6.
The micelle contains a head portion of a mineral-hydrophilic amino acid conjugate and a tail portion of an acrylic polymer.
A cosmetic composition containing hydrophobic amino acids inside the micelles to form a micelle complex.
The hydrophobic amino acid includes at least one selected from the group consisting of glycine, leucine, methionine, valine, alanine, isoleucine, tryptophan, phenylalanine, and proline, according to claim 7. The described cosmetic composition.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63501639A (en) * | 1986-04-22 | 1988-06-23 | ロレアル | Cosmetic or pharmaceutical compositions based on aqueous dispersions of lipid globules |
| JPS63174924A (en) * | 1987-01-14 | 1988-07-19 | Toko Yakuhin Kogyo Kk | Ointment base and ointment |
| JP2002212049A (en) * | 2001-01-18 | 2002-07-31 | Noevir Co Ltd | Skin cosmetic |
| KR20100022000A (en) * | 2007-04-30 | 2010-02-26 | 인터자인 테크놀로지스, 인코포레이티드 | Hybrid block copolymer micelles with mixed stereochemistry for encapsulation of hydrophobic agents |
| JP2018504388A (en) * | 2014-12-24 | 2018-02-15 | ロレアルＬ′Ｏｒｅａｌ | Acoustically activated cosmetic hydrogel |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09124878A (en) * | 1995-10-31 | 1997-05-13 | Shiseido Co Ltd | Gel composition |
| ATE472317T1 (en) * | 2006-03-27 | 2010-07-15 | Nestec Sa | COSMETIC USE OF WHEY PROTEIN MICELLARS |
| CN101600441A (en) * | 2006-06-01 | 2009-12-09 | 治疗剂肽有限公司 | Polymeric biosurfactants |
| CN105813621A (en) * | 2013-12-03 | 2016-07-27 | 荷兰联合利华有限公司 | Personal wash composition |
| KR101819139B1 (en) | 2015-05-11 | 2018-01-18 | 한국과학기술원 | Emulsifier Comprising Amphiphilic Polyether-polyester Block Copolymers and Methods for Preparing the Same |
| KR102324674B1 (en) * | 2015-11-02 | 2021-11-11 | (주)모아캠 | Composition comprising amino acid and mineral extracted from deep ocean water |
| KR102156649B1 (en) * | 2018-11-08 | 2020-09-16 | 충남대학교 산학협력단 | Drug delivery system comprising enzyme-responsive amphiphilic peptide |
| KR102219317B1 (en) * | 2020-10-06 | 2021-02-24 | 엘앤피코스메틱 (주) | A method of producing a cosmetic composition comprising a micelle complex formed by using natural moisturizing factor, and a cosmetic composition formed by the method |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63501639A (en) * | 1986-04-22 | 1988-06-23 | ロレアル | Cosmetic or pharmaceutical compositions based on aqueous dispersions of lipid globules |
| JPS63174924A (en) * | 1987-01-14 | 1988-07-19 | Toko Yakuhin Kogyo Kk | Ointment base and ointment |
| JP2002212049A (en) * | 2001-01-18 | 2002-07-31 | Noevir Co Ltd | Skin cosmetic |
| KR20100022000A (en) * | 2007-04-30 | 2010-02-26 | 인터자인 테크놀로지스, 인코포레이티드 | Hybrid block copolymer micelles with mixed stereochemistry for encapsulation of hydrophobic agents |
| JP2018504388A (en) * | 2014-12-24 | 2018-02-15 | ロレアルＬ′Ｏｒｅａｌ | Acoustically activated cosmetic hydrogel |
Non-Patent Citations (4)
| Title |
|---|
| AMOREPACIFIC, SKIN WATERY CREAM, JPN6021022799, August 2015 (2015-08-01), ISSN: 0004537318 * |
| GUINOT, YOUTH BODY CREAM, JPN6021022801, June 2010 (2010-06-01), ISSN: 0004537319 * |
| HABA, MOISTURE ESSENCE RICH GEL, JPN6021022803, January 2018 (2018-01-01), ISSN: 0004537317 * |
| LABORATOIRES FILORGA, HYDRA-FILLER MAT MOISTURIZER GEL-CREAM [PORES+RADIANCE], JPN6021022802, July 2017 (2017-07-01), ISSN: 0004537316 * |
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