JP2021104993A - Indoor mite repellent, and indoor mite repellent method - Google Patents
Indoor mite repellent, and indoor mite repellent method Download PDFInfo
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- JP2021104993A JP2021104993A JP2020213379A JP2020213379A JP2021104993A JP 2021104993 A JP2021104993 A JP 2021104993A JP 2020213379 A JP2020213379 A JP 2020213379A JP 2020213379 A JP2020213379 A JP 2020213379A JP 2021104993 A JP2021104993 A JP 2021104993A
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- indoor
- mite repellent
- repellent
- indoor mite
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- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
本発明は、屋内ダニ忌避剤、及び屋内ダニ忌避方法に関する。 The present invention relates to an indoor mite repellent and an indoor mite repellent method.
近年、居住環境の変化により、屋内空間にコナダニ、ヒョウヒダニ、ホコリダニ等の屋内塵性ダニ類が大発生し、不快感を与えるばかりでなく、アレルギー性喘息や皮疹を惹起する等の問題を生じている。
そこで、カーペットや寝具等を処理するための屋内用殺ダニ剤が求められてきたが、屋内空間では直接肌に接触する使用場面が多いため、より安全性の高い薬剤の開発が必要とされ、今なお的確な防除法は確立されていない。更に、アレルギー性喘息を引き起こすヒョウヒダニ類は、虫体の死骸そのものでもアレルギーの原因になることが明らかとなってきた。
In recent years, due to changes in the living environment, indoor dust mites such as acarid mites, house dust mites, and dust mites have become outbreaks, causing problems such as allergic asthma and rash as well as causing discomfort. There is.
Therefore, indoor acaricides for treating carpets, bedding, etc. have been demanded, but since there are many usage situations in which they come into direct contact with the skin in indoor spaces, it is necessary to develop safer agents. An accurate control method has not yet been established. Furthermore, it has become clear that house dust mites that cause allergic asthma cause allergies even in the carcasses themselves.
かかる状況を背景として、屋内塵性ダニ類を殺すのではなく、人や患者にダニを近づけないようにする技術も模索され、これまでにいくつかの提案がなされている。例えば、特許文献１（特開平３−２６４５０４号公報）には、ｎ−ヘキシルサリシレート、ｎ−ヘキシルベンゾエートやオイゲノール等を有効成分とする殺ダニまたは屋内ダニ忌避剤が開示されている。また、特許文献２（特開平６−１６５１５号公報）は、室内用ダニ防除剤の有効成分として、ベチバー油、パチョウリ油、クローブ油などの植物精油を開示し、天然産志向と安全性への配慮を謳っているが、屋内塵性ダニ類に対する忌避効果は満足するものとは言えない。 Against this background, techniques for keeping mites away from humans and patients, rather than killing indoor dust mites, have been sought, and several proposals have been made so far. For example, Patent Document 1 (Japanese Unexamined Patent Publication No. 3-264504) discloses an acaricidal or indoor mite repellent containing n-hexyl salicylate, n-hexyl benzoate, eugenol and the like as active ingredients. Further, Patent Document 2 (Japanese Unexamined Patent Publication No. 6-16515) discloses plant essential oils such as vetiver oil, pacholi oil, and clove oil as active ingredients of indoor mite control agents, and is aimed at natural production and safety. Although it claims consideration, it cannot be said that the repellent effect against indoor dust mites is satisfactory.
一方、本発明者らは、先に酢酸シンナミルや桂皮酸メチル等の桂皮酸誘導体がダニ忌避成分として有用であることを知見し、特許文献３（特開２００６−８９４２４号公報）を出願した。 On the other hand, the present inventors have previously discovered that cinnamic acid derivatives such as cinnamyl acetate and methyl cinnamic acid are useful as mite repellent components, and have applied for Patent Document 3 (Japanese Unexamined Patent Publication No. 2006-89424).
これらの屋内ダニ忌避剤は、いずれも精油または香料の成分であり、一般的に強い臭いを持っている。そのため、臭いを生かした製品とする場合や人があまり滞在しないような場所で使用する製品とする場合は良い。しかし、人が常時滞在するようなリビング等の居室で使用する場合は、ほとんど臭いのなく、屋内ダニに対する優れた忌避活性を有する屋内ダニ忌避剤が消費者に求められている。 All of these indoor mite repellents are components of essential oils or fragrances and generally have a strong odor. Therefore, it is good to use a product that makes the best use of the odor or a product that is used in a place where people do not stay much. However, when used in a living room or the like where people always stay, consumers are required to have an indoor mite repellent that has almost no odor and has excellent repellent activity against indoor mites.
そこで、本発明は、消費者の嗜好に合う、実質的に臭いのない屋内ダニ忌避剤を提供することを目的とする。 Therefore, an object of the present invention is to provide an indoor mite repellent that is substantially odorless and that suits the tastes of consumers.
従来、屋内ダニは精油や香料の臭いに反応して近寄らないために、忌避効果を示すと考えられていた。そのため、屋内ダニ忌避活性を示し、ほとんど臭いのない化合物を見出すことは困難であると考えられていた。本発明者らは様々な化合物を鋭意検討した結果、特定の脂肪酸トリシクロデセニルエステルは、屋内ダニに対する優れた忌避活性を有し、さらに、香料と比較してほとんど臭いがないことを見出し、本発明の完成に至った。 Conventionally, indoor mites have been considered to have a repellent effect because they react to the odor of essential oils and fragrances and do not approach. Therefore, it has been considered difficult to find a compound that exhibits indoor mite repellent activity and has almost no odor. As a result of diligent studies of various compounds, the present inventors have found that a specific fatty acid tricyclodecenyl ester has an excellent repellent activity against indoor mites and has almost no odor as compared with a fragrance. The present invention has been completed.
すなわち、本発明は、以下の構成が上記目標達成のために優れた効果を奏することを見出したものである。
（１）下記一般式（１）
で示される脂肪酸トリシクロデセニルエステルを有効成分（ａ）として含有する屋内ダニ忌避剤。
（２）さらに、ｐ−メンタン−３，８−ジオール、３−メチル−５−フェニル−１−ペンタノール、ベンジルベンゾエートからなる群より選択される１種以上を有効成分（ｂ）として含有する（１）に記載の屋内ダニ忌避剤。
（３）屋内空間に（１）又は（２）に記載の屋内ダニ忌避剤を使用する屋内ダニ忌避方法。
（４）前記屋内空間が、容積１８．８〜３３．３ｍ3の居室である（３）に記載の屋内ダニ忌避方法。
That is, the present invention has found that the following configuration exerts an excellent effect for achieving the above-mentioned target.
(1) The following general formula (1)
An indoor mite repellent containing the fatty acid tricyclodecenyl ester represented by (a) as an active ingredient (a).
(2) Further, one or more selected from the group consisting of p-menthane-3,8-diol, 3-methyl-5-phenyl-1-pentanol, and benzylbenzoate is contained as the active ingredient (b) (). The indoor mite repellent according to 1).
(3) An indoor mite repellent method in which the indoor mite repellent according to (1) or (2) is used in an indoor space.
(4) The method for repelling indoor mites according to (3), wherein the indoor space is a living room having a volume of 18.8 to 33.3 m 3.
以下、本発明の屋内ダニ忌避剤、及び屋内ダニ忌避方法について説明する。ただし、本発明は、以下に説明する構成に限定することを意図するものではない。 Hereinafter, the indoor mite repellent agent of the present invention and the indoor mite repellent method will be described. However, the present invention is not intended to be limited to the configurations described below.
本発明の屋内ダニ忌避剤の有効成分（ａ）は下記一般式（１）
本発明の屋内ダニ忌避剤の有効成分である脂肪酸トリシクロデセニルエステルは以下の方法により製造することができる。すなわち、
で示される脂肪酸を用いたエステル化反応などの方法により製造することができる。
The fatty acid tricyclodecenyl ester, which is the active ingredient of the indoor mite repellent of the present invention, can be produced by the following method. That is,
It can be produced by a method such as an esterification reaction using the fatty acid shown in.
これらの化合物は、無色透明であり、実質的に無臭であるが、屋内ダニに対する忌避効果をもち、屋内ダニが生息するのを防ぐことができる。実質的に無臭であるとは、全くの無臭ではないが、香料と比較してほとんど臭いがない無臭性であり、多くの人が臭気を感じにくいものを言う。すなわち、本発明においては、屋内ダニ忌避剤の有効成分に由来する臭いがほとんどないものを言う。 Although these compounds are colorless and transparent and substantially odorless, they have a repellent effect on indoor mites and can prevent the inhabitation of indoor mites. "Substantially odorless" means that it is not completely odorless, but it is odorless with almost no odor as compared with fragrances, and many people are less likely to feel the odor. That is, in the present invention, it means that there is almost no odor derived from the active ingredient of the indoor mite repellent.
さらに、本発明の屋内ダニ忌避剤は、上記有効成分（ａ）に加え、有効成分（ｂ）として、上記有効成分（ａ）に加えて、ｐ−メンタン−３，８−ジオール、３−メチル−５−フェニル−１−ペンタノール、ベンジルベンゾエートからなる群より選択される１種以上を含有することで、無臭性を維持したままで、屋内ダニに対する忌避効果を高めることができる。また、（ｂ）の（ａ）に対する配合比率（質量比）は、０．１≦（ｂ）／（ａ）≦２０であることが好ましく、０．５≦（ｂ）／（ａ）≦１０であることがより好ましい。 Further, the indoor mite repellent of the present invention has p-menthane-3,8-diol, 3-methyl as the active ingredient (b) in addition to the active ingredient (a) in addition to the active ingredient (a). By containing one or more selected from the group consisting of -5-phenyl-1-pentanol and benzylbenzoate, the repellent effect against indoor mites can be enhanced while maintaining odorlessness. The blending ratio (mass ratio) of (b) to (a) is preferably 0.1 ≦ (b) / (a) ≦ 20, and 0.5 ≦ (b) / (a) ≦ 10. Is more preferable.
また、本発明の屋内ダニ忌避剤には防虫効果を付加する目的で、常温揮散性ピレスロイド等を配合することができる。常温揮散性ピレスロイドとしてはエンペントリン、トランスフルトリン、メトフルトリン、プロフルトリン等が挙げられる。 Further, the indoor mite repellent of the present invention may be blended with a room temperature volatilizing pyrethroid or the like for the purpose of adding an insect repellent effect. Examples of the room temperature volatilizing pyrethroid include empentrin, transfluthrin, metoflutrin, profluthrin and the like.
本発明では、屋内ダニ忌避剤の有効成分に由来する臭いがほとんどないという本発明の趣旨を逸脱しない限りにおいて、香料等の他の成分を配合して、消費者の嗜好に合う香り付きの屋内ダニ忌避剤としてもよい。テルピネオール、シトロネロール、ゲラニオール、ネロール、リナロール、ジヒドロリナロール、テトラヒドロリナロール、ジヒドロミルセノール、メントール、ボルネオール、イソボルネオール等のテルペン系アルコール、シトロネラール、シトラール、ジメチルオクタナール等のテルペン系アルデヒド、カルボン、ジヒドロカルボン、プレゴン、メントン等のテルペン系ケトン等があげられるが、これらに限定されない。また、これらの成分を含有する植物精油、例えば、シトロネラ油、シナモン油、ユーカリ油、レモンユーカリ油、ヒバ油、ラベンダー油、オレンジ油、グレープフルーツ油、シダーウッド油、ゼラニウム油、タイムホワイト油、ハッカ油等を配合してもよい。また、ソープ系香料、シトラス系香料、ミント系香料、フローラル系香料、ラベンダー系香料、ローズ系香料、グリーンハーブ系香料等の調合香料を配合してもよい。かかる香料の配合量（質量）は、有効成分（ａ）及び有効成分（ｂ）の配合量の総和（質量）に対して、０．５倍〜２倍であることが好ましく、０．５倍〜１．５倍であることがより好ましい。 In the present invention, as long as it does not deviate from the gist of the present invention that there is almost no odor derived from the active ingredient of the indoor mite repellent, other ingredients such as fragrances are blended to create a scented indoor that suits the taste of the consumer. It may be used as a tick repellent. Terpene alcohols such as terpineol, citronellal, geraniol, nerol, linalool, dihydrolinalol, tetrahydrolinalool, dihydromilsenol, menthol, borneol, isobornole, terpene aldehydes such as citronellal, citral, dimethyloctanal, carboxylic, dihydrocarboxylic , Pregon, Menton and other terpene-based ketones, but are not limited to these. In addition, vegetable essential oils containing these components, such as citronella oil, cinnamon oil, eucalyptus oil, lemon eucalyptus oil, hiba oil, lavender oil, orange oil, grapefruit oil, cedarwood oil, geranium oil, thyme white oil, and peppermint oil. Etc. may be blended. Further, a blended fragrance such as a soap-based fragrance, a citrus-based fragrance, a mint-based fragrance, a floral fragrance, a lavender-based fragrance, a rose-based fragrance, and a green herb-based fragrance may be blended. The blending amount (mass) of the fragrance is preferably 0.5 to 2 times, preferably 0.5 times, the total (mass) of the blending amounts of the active ingredient (a) and the active ingredient (b). More preferably, it is ~ 1.5 times.
本発明の屋内ダニ忌避剤は必要に応じて、２−フェニルフェノール（ＯＰＰ）や４−イソプロピル−３−メチルフェノール（ＩＰＭＰ）等の防黴成分を適宜配合してもよい。また、抗菌成分、除菌成分、消臭成分、ＢＨＴ等の安定化剤、クエン酸等のｐＨ調整剤、着色剤、ビトレックス等の苦味剤などを配合してもよい。また、溶剤、界面活性剤（例えば、後述の液状の屋内ダニ忌避剤の調製で使用できる溶剤、界面活性剤として例示している成分等を配合することができる）なども適宜配合してもよい。これらの各種成分は特に限定されない。 If necessary, the indoor mite repellent of the present invention may appropriately contain antifungal components such as 2-phenylphenol (OPP) and 4-isopropyl-3-methylphenol (IPMP). Further, an antibacterial component, a sterilizing component, a deodorizing component, a stabilizer such as BHT, a pH adjusting agent such as citric acid, a coloring agent, a bittering agent such as Vitrex, etc. may be blended. Further, a solvent, a surfactant (for example, a solvent that can be used in the preparation of a liquid indoor mite repellent described later, a component exemplified as a surfactant, etc. can be blended) and the like may be appropriately blended. .. These various components are not particularly limited.
本発明では、屋内ダニ忌避剤原液を調製し、使用場面のニーズ等に合わせて、液状、ゲル状、ビーズ状、固形状、シート状等の種々形態として製剤化できる。ここで、屋内ダニ忌避剤原液中の有効成分（ａ）の配合量は、０．１質量％〜１．０質量％であることが好ましく、有効成分（ｂ）の配合量は、０．１質量％〜２．０質量％であることが好ましい。 In the present invention, an indoor mite repellent stock solution can be prepared and formulated in various forms such as liquid, gel, bead, solid, and sheet according to the needs of the usage scene. Here, the blending amount of the active ingredient (a) in the indoor mite repellent stock solution is preferably 0.1% by mass to 1.0% by mass, and the blending amount of the active ingredient (b) is 0.1. It is preferably from mass% to 2.0 mass%.
液状の屋内ダニ忌避剤を調製するにあたって使用できる溶剤や界面活性剤等の各種成分は特に限定されないが、水のほか、エタノール、イソプロパノールのようなアルコール系溶剤、１,３−ブチレングリコール、プロピレングリコール、ジプロピレングリコールのようなグリコール系溶剤、ジエチレングリコールモノブチルエーテル、プロピレングリコールモノメチルエーテル等のグリコールエーテル系溶剤、脂肪族炭化水素系溶剤等の各種溶剤や、界面活性剤（可溶化剤）等が適宜用いられる。
界面活性剤としては、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレン高級アルキルエーテル（ポリオキシエチレンラウリルエーテル、ポリオキシエチレンオレイルエーテル）、ポリオキシエチレン高級脂肪酸エステル、ポリオキシエチレンポリオキシプロピレンアルキルエーテル等の非イオン系界面活性剤や、ラウリルアミンオキサイド、ステアリルアミンオキサイド、ラウリル酸アミドプロピルジメチルアミンオキサイド等の高級アルキルアミンオキサイド系界面活性剤等を例示できる。
Various components such as solvents and surfactants that can be used to prepare the liquid indoor tick repellent are not particularly limited, but in addition to water, alcohol-based solvents such as ethanol and isopropanol, 1,3-butylene glycol, and propylene glycol are used. , Glycol solvents such as dipropylene glycol, glycol ether solvents such as diethylene glycol monobutyl ether and propylene glycol monomethyl ether, various solvents such as aliphatic hydrocarbon solvents, surfactants (solubilizers) and the like are appropriately used. Be done.
Surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene higher alkyl ether (polyoxyethylene lauryl ether, polyoxyethylene oleyl ether), polyoxyethylene higher fatty acid ester, polyoxyethylene polyoxypropylene alkyl ether, etc. Examples thereof include nonionic surfactants and higher alkylamine oxide-based surfactants such as laurylamine oxide, stearylamine oxide, and lauric acid amidopropyldimethylamine oxide.
ゲル状体の調製に用いられるゲル化剤としては、カラギーナン、キサンタンガム、ジェランガム、ゼラチン、オクチル酸アルミニウム、１２−ヒドロキシステアリン酸などがあげられる。 Examples of the gelling agent used for preparing the gel form include carrageenan, xanthan gum, gellan gum, gelatin, aluminum octylate, and 12-hydroxystearic acid.
ビーズ状体としては、特定の吸水性ポリマーによるゲルビーズに、液状の屋内ダニ忌避剤の成分を保持させ調製できる。水性ゲルビーズを形成する吸水性ポリマーには、アクリル酸系吸水性ポリマーが好ましく使用される。アクリル酸系吸水性ポリマーは、吸水性に優れており、自重の１００倍以上の水を吸収することができる。粒径約２ｍｍ程度（１．５ｍｍ〜２．５ｍｍ）のアクリル酸系吸水性ポリマーであれば、含浸液を吸収した後も略透明な状態を維持しつつ、粒径約１０ｍｍ程度（６ｍｍ〜１０ｍｍ）にまで膨張し得る。アクリル酸系吸水性ポリマーとしては、アクリル酸／アクリル酸塩共重合体（アクリル酸／アクリル酸ナトリウム塩共重合体やアクリル酸／アクリル酸カリウム塩共重合体等）やアクリルアミド／アクリル酸又はその塩の共重合体が挙げられる。 The bead-like body can be prepared by allowing gel beads made of a specific water-absorbing polymer to retain the components of a liquid indoor mite repellent. Acrylic acid-based water-absorbent polymer is preferably used as the water-absorbent polymer forming the water-based gel beads. The acrylic acid-based water-absorbent polymer has excellent water absorption and can absorb 100 times or more of its own weight. An acrylic acid-based water-absorbent polymer having a particle size of about 2 mm (1.5 mm to 2.5 mm) maintains a substantially transparent state even after absorbing the impregnating liquid, and has a particle size of about 10 mm (6 mm to 10 mm). ) Can be expanded. Examples of the acrylic acid-based water-absorbent polymer include acrylic acid / acrylic acid salt copolymer (acrylic acid / sodium acrylic acid salt copolymer, acrylic acid / potassium acrylic acid salt copolymer, etc.), acrylamide / acrylic acid, or a salt thereof. Copolymers of.
本発明の屋内ダニ忌避剤の成分を固形担体に含浸又は保持させた場合は、通気性ケースもしくは袋に収納して製剤とすることができる。そして、かかる屋内ダニ忌避剤を、リビング、キッチン等の居室に設置し、固形担体から有効成分を揮散させればよい。固形担体としては、パルプ、リンター、レーヨン等の繊維質担体、セルロース（再生セルロース）製ビーズもしくは発泡体、ケイ酸塩、シリカ、ゼオライト等の無機多孔質担体、トリオキサン、アダマンタン等の昇華性担体等があげられる。繊維質担体では厚さが１〜３ｍｍ程度のマットもしくはシート状のものが使い易く、一方、セルロース製ビーズの場合、これに炭を配合することによって消臭効果を付与することもできる。 When the component of the indoor mite repellent of the present invention is impregnated or retained in a solid carrier, it can be stored in a breathable case or bag to form a preparation. Then, the indoor mite repellent may be installed in a living room such as a living room or a kitchen to volatilize the active ingredient from the solid carrier. Examples of the solid carrier include fibrous carriers such as pulp, linter and rayon, inorganic porous carriers such as cellulose (regenerated cellulose) beads or foams, silicates, silica and zeolite, and sublimable carriers such as trioxane and adamantan. Can be given. As the fibrous carrier, a mat or sheet having a thickness of about 1 to 3 mm is easy to use, while in the case of cellulose beads, a deodorizing effect can be imparted by blending charcoal with the bead.
その際の通気性ケースとしては、例えば、開孔部を有するプラスチック製容器等があげられ、通気性袋としては、不織布袋、綿袋、ネットケース等を例示できる。後者の不織布袋の場合、不織布の材質は特に限定されず、例えば、ポリエステル（ＰＥＴ）、ポリエチレン（ＰＥ）、ポリプロピレン（ＰＰ）、ポリアミド、ポリ乳酸、レーヨン等があげられ、これらは単一の繊維であってもよいし、あるいは紙を積層したポリエステルやポリプロピレン／レーヨンのような積層品（有効成分を一部吸着してその揮散量を二次的に調節可能）や混紡品を用いても構わない。また、不織布袋の形状や構成も適宜決定することができ、例えば、両面を前記材質の通気性不織布で構成してもよいし、あるいは、片面が前記材質の通気性不織布で、他面が小孔を多数有してもよいプラスチックフィルムを貼り合わせたものであってもよい。 Examples of the breathable case include a plastic container having a perforated portion, and examples of the breathable bag include a non-woven fabric bag, a cotton bag, and a net case. In the case of the latter non-woven fabric bag, the material of the non-woven fabric is not particularly limited, and examples thereof include polyester (PET), polyethylene (PE), polypropylene (PP), polyamide, polylactic acid, rayon, etc., and these are single fibers. Alternatively, a laminated product such as polyester or polypropylene / rayon on which paper is laminated (the amount of volatilization thereof can be adjusted secondarily by adsorbing a part of the active ingredient) or a blended product may be used. do not have. Further, the shape and composition of the non-woven fabric bag can be appropriately determined. For example, both sides may be made of the breathable non-woven fabric of the above material, or one side is made of the breathable non-woven fabric of the above material and the other side is small. It may be made by laminating a plastic film which may have a large number of holes.
本発明の屋内ダニ忌避剤全体量に対する有効成分の配合量は、製剤の形態によっても異なるが、屋内ダニ忌避剤一個当たり０．１ｍｇ〜１０ｇ程度に設定するのが好適である。また、使用する空間の体積に応じて適宜施用個数を設定すればよい。 The blending amount of the active ingredient with respect to the total amount of the indoor mite repellent of the present invention varies depending on the form of the pharmaceutical product, but it is preferably set to about 0.1 mg to 10 g per indoor mite repellent. In addition, the number of applications may be appropriately set according to the volume of the space to be used.
このようにして得られた屋内ダニ忌避剤は、屋内空間で使用することができ、リビング、キッチン、寝室等の約４．５〜８畳に相当する（容積１８．８〜３３．３ｍ3であり、床面積７．５〜１３．３ｍ2、高さ２．２〜３．０ｍ）大きさの居室でも使用者が屋内ダニ忌避剤の有効成分に由来する臭気をほとんど感じることなく、屋内ダニを忌避することができるため快適に使用することができる。また、タンス、引き出し、クローゼットや衣類収容箱に密閉空間に近い空間においても有効成分に由来する臭いを気にすることなく使用することができる。各種含浸担体から有効成分が揮散し、ケナガコナダニ、コナヒョウヒダニ、ヤケヒョウヒダニ、ツメダニ等の屋内塵性ダニ類に対して実用的な忌避効果を奏するものであり、実用性は高い。また、忌避対象としてはこれらのダニ類に限定されるものではない。 The indoor mite repellent thus obtained can be used in an indoor space and corresponds to about 4.5 to 8 tatami mats in a living room, kitchen, bedroom, etc. (with a volume of 18.8 to 33.3 m 3) . There is a floor area of 7.5 to 13.3 m 2 , and a height of 2.2 to 3.0 m). Even in a living room, the user hardly feels the odor derived from the active ingredient of the indoor mite repellent, and the indoor mites. Can be used comfortably because it can repel. In addition, it can be used in a closet, a drawer, a closet, or a clothes storage box in a space close to a closed space without worrying about the odor derived from the active ingredient. The active ingredient volatilizes from various impregnated carriers and exerts a practical repellent effect on indoor dust mites such as Tyrophagus putrescentiae, Dermatophagoides farinae, Dermatophagoides farinae, and Cheyletidae, and is highly practical. Moreover, the repellent target is not limited to these mites.
次に、具体的な実施例に基づき、本発明の屋内ダニ忌避剤について更に詳細に説明する。ただし、本発明はこれらに限定されるものではない。 Next, the indoor mite repellent of the present invention will be described in more detail based on specific examples. However, the present invention is not limited thereto.
＜ダニ忌避効力試験＞
各試験において薬量が２００ｍｇ／ｍ２となるように処理し、ＪＩＳ Ｌ １９２０記載の侵入阻止法に準じてダニ忌避効力試験を行い、次式により侵入阻止率を算出した。
侵入阻止率（％）＝［無処理区の侵入ダニ数−処理区の侵入ダニ数］／無処理区の侵入ダニ数×１００
そして、得られた侵入阻止率から、さらに以下の基準で各成分のダニ忌避効果の評価を行った。
◎：侵入阻止率９０〜１００％、○：侵入阻止率７０〜９０％、△：侵入阻止率５０〜７０％、×：侵入阻止率＜５０％
<Tick repellent efficacy test>
In each test, the dose was treated to 200 mg / m 2 , a tick repellent efficacy test was conducted according to the invasion prevention method described in JIS L 1920, and the invasion prevention rate was calculated by the following formula.
Invasion prevention rate (%) = [Number of invading mites in untreated area-Number of invading mites in treated area] / Number of invading mites in untreated area x 100
Then, based on the obtained invasion prevention rate, the mite repellent effect of each component was further evaluated according to the following criteria.
⊚: Intrusion prevention rate 90 to 100%, ○: Intrusion prevention rate 70 to 90%, Δ: Intrusion prevention rate 50 to 70%, ×: Intrusion prevention rate <50%
ダニ忌避試験の結果を表１に示した。（表中、成分名は有効成分名を表す。） The results of the tick repellent test are shown in Table 1. (In the table, the ingredient name represents the active ingredient name.)
＜無臭性確認試験＞
表２記載の各々の成分１０ｍｇを底面積６ｃｍ２のシャーレに塗布して、容量約１４Ｌのアルミ円筒の底面中央に設置し、５分間密閉した。その後、アルミ円筒の一部を開放して２０代〜５０代の５人のパネラーにより臭気の有無を以下の基準で評価をした。
◎；５人中０〜１人が臭気を感じる。〇；５人中２人が臭気を感じる。△；５人中３人が臭気を感じる。×；５人中４〜５人が臭気を感じる。
<Odorless confirmation test>
10 mg of each component shown in Table 2 was applied to a petri dish having a bottom area of 6 cm 2 , placed in the center of the bottom surface of an aluminum cylinder having a capacity of about 14 L, and sealed for 5 minutes. After that, a part of the aluminum cylinder was opened and the presence or absence of odor was evaluated by five panelists in their twenties to fifties according to the following criteria.
◎; 0 to 1 out of 5 people feel an odor. 〇; 2 out of 5 people feel an odor. Δ: 3 out of 5 people feel an odor. X; 4 to 5 out of 5 people feel an odor.
無臭性確認試験の結果を表２に示した。（表中、成分名は有効成分名を表す。） The results of the odorless confirmation test are shown in Table 2. (In the table, the ingredient name represents the active ingredient name.)
ダニ忌避試験と無臭性確認試験の結果より、Ｒは直鎖構造又は分岐構造を有し、炭素数１〜４の飽和炭化水素である脂肪酸トリシクロデセニルエステルはダニ忌避効果を示し、さらにほとんど臭いがないことが分かった。さらに、ｐ−メンタン−３，８−ジオール、３−メチル−５−フェニル−１−ペンタノール、ベンジルベンゾエートからなる群より選ばれる１種以上を含有すると、有効成分の無臭性を維持したまま、屋内ダニに対する忌避効果を高めることができることが分かった。一方、酢酸シンナミルは優れたダニ忌避効果を示すが、臭気が感じられた。Ｒが炭素数１未満の脂肪酸トリシクロデセニルエステルやＲが炭素数４を上回る脂肪酸トリシクロデセニルエステルはダニ忌避活性と有効成分の無臭性の点で劣った結果となった。また、トリシクロデセニルノルマルプロピオネートにｐ−メンタン−３，８−ジオール、３−メチル−５−フェニル−１−ペンタノール、ベンジルベンゾエートからなる群から選ばれる１種以上でないエチルベンゾエートを加えても、屋内ダニに対する忌避効果を高めることができず、臭いも感じられた。 From the results of the mite repellent test and the odorless confirmation test, R has a linear structure or a branched structure, and the fatty acid tricyclodecenyl ester, which is a saturated hydrocarbon having 1 to 4 carbon atoms, shows a mite repellent effect, and most of them. It turned out that there was no odor. Further, when one or more selected from the group consisting of p-menthane-3,8-diol, 3-methyl-5-phenyl-1-pentanol and benzylbenzoate is contained, the odorlessness of the active ingredient is maintained. It was found that the repellent effect against indoor mites can be enhanced. On the other hand, cinnamyl acetate showed an excellent mite repellent effect, but an odor was felt. The fatty acid tricyclodecenyl ester having an R of less than 1 carbon atom and the fatty acid tricyclodecenyl ester having an R of more than 4 carbon atoms were inferior in terms of mite repellent activity and odorlessness of the active ingredient. In addition, tricyclodecenyl normal propionate contains not one or more ethyl benzoates selected from the group consisting of p-menthane-3,8-diol, 3-methyl-5-phenyl-1-pentanol, and benzyl benzoate. In addition, the repellent effect against indoor mites could not be enhanced, and an odor was also felt.
（実施例１０）
トリシクロデセニルノルマルプロピオネート２０質量％、３−メチル−５−フェニル−１−ペンタノール５０質量％、及びその他成分を配合した屋内ダニ忌避組成物を調製した。
次に、この屋内ダニ忌避組成物１０ｇに、界面活性剤として、ポリオキシエチレンラウリルエーテル５．０ｇ、ポリオキシエチレン硬化ヒマシ油２．０ｇ、及びラウリン酸アミドプロピルアミンオキシド１．８ｇを加え、さらに溶剤としてエタノール２０ｇ、消臭成分として緑茶抽出物１．５ｇ、安定剤としてＢＨＴ１．９ｇ、微量のイソチアゾリン系防腐剤、微量の苦味剤（ビトレックス）、及び適量の水を配合し、全体を３８６ｇとして含浸液（屋内ダニ忌避剤原液）を調製した。
(Example 10)
An indoor mite repellent composition containing 20% by mass of tricyclodecenyl normal propionate, 50% by mass of 3-methyl-5-phenyl-1-pentanol, and other components was prepared.
Next, 5.0 g of polyoxyethylene lauryl ether, 2.0 g of polyoxyethylene hydrogenated castor oil, and 1.8 g of amidopropylamine laurate oxide were added as surfactants to 10 g of this indoor tick repellent composition, and further. 20 g of ethanol as a solvent, 1.5 g of green tea extract as a deodorant component, 1.9 g of BHT as a stabilizer, a trace amount of isothiazoline-based preservative, a trace amount of bitterant (Vitrex), and an appropriate amount of water are mixed, and the total is 386 g. An impregnating solution (stock solution of indoor mite repellent) was prepared as an impregnating solution.
上面に総面積２４ｃｍ２の開口部を有し、容量が５００ｍＬの円筒状のプラスチック容器（φ：８ｃｍ、高さ：１０ｃｍ）に、吸水性ポリマーとして、粒径が約２ｍｍのアクリル酸／アクリル酸ナトリウム塩共重合体１４ｇを入れた。これに上記含浸液（屋内ダニ忌避剤原液）を注ぎ込んだ
ところ、吸水性ポリマーが膨潤し、粒径が約１０ｍｍの本発明の水性ゲルビーズタイプの屋内ダニ忌避剤１が得られた。
Acrylic acid / acrylic acid with a particle size of about 2 mm as a water-absorbing polymer in a cylindrical plastic container (φ: 8 cm, height: 10 cm) with a total area of 24 cm 2 on the upper surface and a capacity of 500 mL. 14 g of the sodium salt copolymer was added. When the impregnated solution (stock solution of indoor mite repellent) was poured into this, the water-absorbent polymer swelled, and the aqueous gel bead type indoor mite repellent 1 of the present invention having a particle size of about 10 mm was obtained.
（実施例１１）
トリシクロデセニルアセテート１０質量％、ベンジルベンゾエート２０質量％、及びその他成分を配合した屋内ダニ忌避組成物を調製した。
次に、この屋内ダニ忌避組成物１０ｇに、界面活性剤として、ポリオキシエチレンラウリルエーテル５．０ｇ、ポリオキシエチレン硬化ヒマシ油２．０ｇ、及びラウリン酸アミドプロピルアミンオキシド１．８ｇを加え、さらに溶剤としてエタノール２０ｇ、消臭成分として緑茶抽出物１．５ｇ、安定剤としてＢＨＴ１．９ｇ、微量のイソチアゾリン系防腐剤、微量の苦味剤（ビトレックス）、及び適量の水を配合し、全体を３８６ｇとして含浸液（屋内ダニ忌避剤原液）を調製した。
(Example 11)
An indoor mite repellent composition containing 10% by mass of tricyclodecenyl acetate, 20% by mass of benzylbenzoate, and other components was prepared.
Next, 5.0 g of polyoxyethylene lauryl ether, 2.0 g of polyoxyethylene hydrogenated castor oil, and 1.8 g of amidopropylamine laurate oxide were added as surfactants to 10 g of this indoor tick repellent composition, and further. 20 g of ethanol as a solvent, 1.5 g of green tea extract as a deodorant component, 1.9 g of BHT as a stabilizer, a trace amount of isothiazoline-based preservative, a trace amount of bitterant (Vitrex), and an appropriate amount of water are mixed, and the total is 386 g. An impregnating solution (stock solution of indoor mite repellent) was prepared as an impregnating solution.
上面に総面積２４ｃｍ２の開口部を有し、容量が５００ｍＬの円筒状のプラスチック容器（φ：８ｃｍ、高さ：１０ｃｍ）に、吸水性ポリマーとして、粒径が約２ｍｍのアクリル酸／アクリル酸ナトリウム塩共重合体１４ｇを入れた。これに上記含浸液（屋内ダニ忌避剤原液）を注ぎ込んだところ、吸水性ポリマーが膨潤し、粒径が約１０ｍｍの本発明の水性ゲルビーズタイプの屋内ダニ忌避剤２が得られた。 Acrylic acid / acrylic acid with a particle size of about 2 mm as a water-absorbing polymer in a cylindrical plastic container (φ: 8 cm, height: 10 cm) with a total area of 24 cm 2 on the upper surface and a capacity of 500 mL. 14 g of the sodium salt copolymer was added. When the impregnated solution (stock solution of indoor mite repellent) was poured into this, the water-absorbent polymer swelled, and the aqueous gel bead type indoor mite repellent 2 of the present invention having a particle size of about 10 mm was obtained.
実施例１０及び１１で得られた水性ゲルビーズタイプのダニ忌避剤１及び２をクローゼット内においてそれぞれ使用した。１週間後にクローゼット内を確認したところ、水性ゲルビーズタイプの屋内ダニ忌避剤１及び２のいずれを用いた場合でもダニの寄り付きは認められず、また、クローゼット内は屋内ダニ忌避剤の有効成分に由来する臭いがほとんどなく、極めて実用性の高いものであった。 The aqueous gel bead type mite repellents 1 and 2 obtained in Examples 10 and 11 were used in the closet, respectively. When the inside of the closet was checked one week later, no ticks were observed when any of the aqueous gel bead type indoor mite repellents 1 and 2 was used, and the inside of the closet was derived from the active ingredient of the indoor mite repellent. It was extremely practical with almost no odor.
（実施例１２）
トリシクロデセニルノルマルプロピオネート１０質量％、３−メチル−５−フェニル−１−ペンタノール２５質量％、ソープ系香料２０質量％、及びその他成分を配合した屋内ダニ忌避組成物を調製した。
次に、この屋内ダニ忌避組成物１０ｇに、界面活性剤として、ポリオキシエチレンラウリルエーテル５．０ｇ、ポリオキシエチレン硬化ヒマシ油２．０ｇ、及びラウリン酸アミドプロピルアミンオキシド１．８ｇを加え、さらに溶剤としてエタノール２０ｇ、消臭成分として緑茶抽出物１．５ｇ、安定剤としてＢＨＴ１．９ｇ、微量のイソチアゾリン系防腐剤、微量の苦味剤（ビトレックス）、及び適量の水を配合し、全体を３８６ｇとして含浸液（屋内ダニ忌避剤原液）を調製した。
(Example 12)
An indoor mite repellent composition containing 10% by mass of tricyclodecenyl normal propionate, 25% by mass of 3-methyl-5-phenyl-1-pentanol, 20% by mass of soap-based fragrance, and other ingredients was prepared. ..
Next, 5.0 g of polyoxyethylene lauryl ether, 2.0 g of polyoxyethylene hydrogenated castor oil, and 1.8 g of amidopropylamine laurate oxide were added as surfactants to 10 g of this indoor tick repellent composition, and further. 20 g of ethanol as a solvent, 1.5 g of green tea extract as a deodorant component, 1.9 g of BHT as a stabilizer, a trace amount of isothiazoline-based preservative, a trace amount of bitterant (Vitrex), and an appropriate amount of water are mixed, and the total is 386 g. An impregnating solution (stock solution of indoor mite repellent) was prepared as an impregnating solution.
上面に総面積２４ｃｍ２の開口部を有し、容量が５００ｍＬの円筒状のプラスチック容器（φ：８ｃｍ、高さ：１０ｃｍ）に、吸水性ポリマーとして、粒径が約１．８ｍｍのアクリル酸／アクリル酸ナトリウム塩共重合体１４ｇを入れた。これに上記含浸液（屋内ダニ忌避剤原液）を注ぎ込んだところ、吸水性ポリマーが膨潤し、粒径が約８ｍｍの本発明の水性ゲルビーズタイプの屋内ダニ忌避剤３が得られた。 Acrylic acid with a particle size of about 1.8 mm as a water-absorbent polymer in a cylindrical plastic container (φ: 8 cm, height: 10 cm) with a total area of 24 cm 2 on the upper surface and a capacity of 500 mL. 14 g of sodium acrylate copolymer was added. When the impregnated solution (stock solution of indoor mite repellent) was poured into this, the water-absorbent polymer swelled, and the aqueous gel bead type indoor mite repellent 3 of the present invention having a particle size of about 8 mm was obtained.
実施例１２で得られた水性ゲルビーズタイプの屋内ダニ忌避剤３をクローゼット内において使用した。１週間後にクローゼット内を確認したところ、水性ゲルビーズタイプの屋内ダニ忌避剤３を用いた場合、ダニの寄り付きは認められず、また、クローゼット内は屋内ダニ忌避剤の有効成分に由来する臭いがほとんどなく、せっけんの爽やかな香りが感じられ、極めて実用性の高いものであった。 The aqueous gel bead type indoor mite repellent 3 obtained in Example 12 was used in the closet. When the inside of the closet was checked one week later, when the water-based gel bead type indoor mite repellent 3 was used, no ticks were observed, and the inside of the closet had almost no odor derived from the active ingredient of the indoor mite repellent. The refreshing scent of mite was felt, and it was extremely practical.
本発明は、ダニ忌避剤として、広く利用可能である。
The present invention is widely available as a tick repellent.
Claims (4)
で示される脂肪酸トリシクロデセニルエステルを有効成分（ａ）として含有する屋内ダニ忌避剤。 The following general formula (1)
An indoor mite repellent containing the fatty acid tricyclodecenyl ester represented by (a) as an active ingredient (a).
The method for repelling indoor mites according to claim 3 , wherein the indoor space is a living room having a volume of 18.8 to 33.3 m 3.
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