JP2020524599A - 微小液滴操作装置 - Google Patents
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Abstract
Description
Claims (18)
- 第1複合壁であり、
第1透明基板、
前記第1透明基板上の、70〜250nmの厚さを有する第1透明導体層、
前記第1透明導体層上の、300〜1000nmの厚さを有し、400〜1000nmの波長範囲の電磁照射によって活性化される光活性層、及び
前記第1透明導体層上の、120〜160nmの厚さを有する第1誘電体層
からなる第1複合壁と、
第2複合壁であり、
第2基板、
前記第2基板上の、70〜250nmの厚さを有する第2導体層、及び
任意に、前記第2導体層上の、120〜160nmの厚さを有する第2誘電体層
からなる第2複合壁と、
前記第1複合壁及び第2複合壁にわたって、前記第1透明導体層及び第2導体層を接続する電圧を供給する交流電源と、
前記光活性層に衝突させて、前記第1誘電体層の表面上の対応する一過性エレクトロウェッティング箇所を誘起するように適合される光励起層のバンドギャップより高いエネルギを有する少なくとも1つの電磁放射源と、
前記一過性エレクトロウェッティング箇所の配置を変えることにより、少なくとも1つのエレクトロウェッティング経路を生成し、前記エレクトロウェッティング経路に沿って微小液滴を移動させることができるように、前記光活性層上での前記電磁照射の衝突点を操作する手段と、
から本質的になり、
前記第1誘電体層及び第2誘電体層の露出面は、10μm未満の間隔で配置されて、微小液滴を含むように適合されるマイクロ流体空間を画定する、
光学的に媒介されるエレクトロウェッティングを用いて微小液滴を操作する装置。 - 前記第1複合壁及び第2複合壁がそれぞれ、前記第1誘電体層及び前記第2誘電体層上に、第1防汚層及び第2防汚層を更に備えることを特徴とする、請求項1に記載の装置。
- 前記第2誘電体層上の防汚層が疎水性であることを特徴とする、請求項1又は2に記載の装置。
- 前記マイクロ流体空間は、前記第1誘電体層及び第2誘電体層に取り付けられるスペーサによって更に画定されることを特徴とする、請求項1〜3のいずれか一項に記載の装置。
- 前記エレクトロウェッティング経路は、前記装置使用中のある時点において、それぞれ一過性エレクトロウェッティングが行われる、仮想的エレクトロウェッティング箇所の連続体からなることを特徴とする、請求項1〜4のいずれか一項に記載の装置。
- 前記マイクロ流体空間は、2μm〜8μmであることを特徴とする、請求項1〜5のいずれか一項に記載の装置。
- 前記電磁放射源は、ピクセル化されるアレイ、又はこのようなアレイから反射され若しくはこのようなアレイを透過する光を含むことを特徴とする、請求項1〜6のいずれか一項に記載の装置。
- 前記エレクトロウェッティング箇所は、前記微小液滴の移動方向に三日月形状であることを特徴とする、請求項1〜7のいずれか一項に記載の装置。
- 前記装置内又は前記装置の下流に配置される前記微小液滴の蛍光を刺激し検出する手段を更に備えることを特徴とする、請求項1〜8のいずれか一項に記載の装置。
- 不混和性キャリア流体の水性微小液滴のエマルションからなる媒体を生成する手段を更に備えることを特徴とする、請求項1〜9のいずれか一項に記載の装置。
- 前記マイクロ流体空間への入口を経て前記マイクロ流体空間を通る、不混和性キャリア流体の水性微小液滴のエマルションからなる媒体の流れを誘起する手段を更に備えることを特徴とする、請求項1〜10のいずれか一項に記載の装置。
- 前記第1複合壁及び第2複合壁は、第1複合シート及び第2複合シートであり、前記第1複合シート及び第2複合シートは、前記第1複合シート及び第2複合シートの間に前記マイクロ流体空間を画定し、カートリッジ又はチップの外周部を形成することを特徴とする、請求項1〜11のいずれか一項に記載の装置。
- 互いに付随して走る複数の第1エレクトロウェッティング経路を更に備えることを特徴とする、請求項12に記載の装置。
- 前記第1エレクトロウェッティング経路と交差して、少なくとも1つの微小液滴合流箇所を作るように適合される、複数の第2エレクトロウェッティング経路を更に備えることを特徴とする、請求項13に記載の装置。
- 前記マイクロ流体空間に微小液滴を導入する手段を更に備え、
前記手段の直径は、前記マイクロ流体空間の幅よりも20%超大きいことを特徴とする、請求項1〜14のいずれか一項に記載の装置。 - 前記第2複合壁が、第2光励起性層を更に含み、
前記電磁放射源は、前記第2光励起性層にも衝突して、同様に変わり得る一過性エレクトロウェッティング箇所の第2パターンを作ることを特徴とする、請求項1〜15のいずれか一項に記載の装置。 - スペーサを使用して、第1層の構造と第2層の構造との間の間隔を制御し、
前記スペーサの物理的形状を用いて、前記装置の前記微小液滴の分離、統合及び伸長を助ける、請求項1〜16のいずれか一項に記載の装置。 - (a)不混和性キャリア媒体の微小液滴のエマルションを、10μm未満の間隔で又は10μm未満離れて配置される2つの対向する壁により画定されるマイクロ流体空間に導入するステップと、
(b)複数位置の電磁放射源を、光活性層に適用して、第1誘電体層において、複数の対応する一過性エレクトロウェッティング箇所を誘起するステップと、
(c)前記光活性層の前記電磁放射源の適用位置を変えることで、前記エマルションの前記微小液滴の少なくとも1つを、前記一過性エレクトロウェッティング箇所によって生み出されるエレクトロウェッティング経路に沿って移動するステップと、
を含む、水性微小液滴の操作方法であり、
前記2つの対向する壁はそれぞれ、
第1複合壁であり、
第1透明基板、
前記第1透明基板上の、70〜250nmの厚さを有する第1透明導体層、
前記第1透明導体層上の、300〜1000nmの厚さを有し、400〜1000nmの波長範囲の電磁照射によって活性化される前記光活性層、及び
前記第1透明導体層上の、120〜160nmの厚さを有する前記第1誘電体層
からなる第1複合壁と、
第2複合壁であり、
第2基板、
前記第2基板上の、70〜250nmの厚さを有する第2導体層、及び
任意に、前記第2導体層上の、120〜160nmの厚さを有する第2誘電体層
からなる第2複合壁と、を備える、前記水性微小液滴の操作方法。
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Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2018288533B2 (en) | 2017-06-21 | 2023-07-13 | Lightcast Discovery Ltd | Microfluidic analytical device |
KR20240017985A (ko) | 2017-06-21 | 2024-02-08 | 베이스4 이노베이션 엘티디 | 마이크로 액적 조작 장치 |
GB2577536A (en) * | 2018-09-28 | 2020-04-01 | Acxel Tech Ltd | Droplet actuation |
GB201909514D0 (en) | 2018-11-20 | 2019-08-14 | Lightcast Discovery Ltd | Device and method for microdroplet detection of cells |
WO2020169965A1 (en) * | 2019-02-19 | 2020-08-27 | Lightcast Discovery Ltd | Microdroplet manipulation device |
GB201910035D0 (en) | 2019-07-12 | 2019-08-28 | Lightcast Discovery Ltd | Apparatus and methods for manipulating microdroplets |
GB201914724D0 (en) | 2019-10-11 | 2019-11-27 | Lightcast Discovery Ltd | Method and apparatus for clinical testing |
GB201915027D0 (en) | 2019-10-17 | 2019-12-04 | Lightcast Discovery Ltd | Apparatus and methods for manipulating microdroplets |
GB202001051D0 (en) | 2020-01-24 | 2020-03-11 | Lightcast Discovery Ltd | Methods and apparatus for high throughput microdroplet manipulation |
GB202007249D0 (en) | 2020-05-15 | 2020-07-01 | Lightcast Discovery Ltd | Improvements to apparatus and methods for manipulating microdroplets |
US11852905B2 (en) * | 2020-12-22 | 2023-12-26 | Meta Platforms Technologies, Llc | Photowetting optical element |
GB202103609D0 (en) | 2021-03-16 | 2021-04-28 | Lightcast Discovery Ltd | Method of selecting cells |
GB2625341A (en) * | 2022-12-14 | 2024-06-19 | Lightcast Discovery Ltd | Improvements in or relating to a cartridge |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005030987A (ja) * | 2003-07-09 | 2005-02-03 | Olympus Corp | 液体搬送処理システム |
JP2005531409A (ja) * | 2002-05-31 | 2005-10-20 | ザ リージェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア | 光・電気濡れに基づくマイクロフルイディクスの光学的駆動のための装置と方法 |
JP2006300946A (ja) * | 2005-04-19 | 2006-11-02 | Commissariat A L'energie Atomique | マイクロ流体の方法および質量を二種の不混和性相間で移送する装置 |
JP2009534653A (ja) * | 2006-04-18 | 2009-09-24 | アドバンスド・リキッド・ロジック・インコーポレイテッド | 液滴に基づく生化学 |
JP2010503516A (ja) * | 2006-05-09 | 2010-02-04 | アドバンスド・リキッド・ロジック・インコーポレイテッド | 液滴処置システム |
WO2010095577A1 (ja) * | 2009-02-17 | 2010-08-26 | 株式会社日立製作所 | 液滴微粒化装置 |
US20120044299A1 (en) * | 2009-08-14 | 2012-02-23 | Advanced Liquid Logic, Inc. | Droplet Actuator Devices and Methods |
JP2015527061A (ja) * | 2012-06-27 | 2015-09-17 | アドバンスト リキッド ロジック インコーポレイテッドAdvanced Liquid Logic, Inc. | 泡形成を低減するための技術および液滴アクチュエーターの設計 |
US20160160259A1 (en) * | 2014-12-09 | 2016-06-09 | Berkeley Lights, Inc. | Automated detection of assay-positive areas in microfluidic devices |
JP2016153725A (ja) * | 2015-02-20 | 2016-08-25 | パナソニックIpマネジメント株式会社 | 液滴輸送装置の駆動方法 |
US20170043343A1 (en) * | 2014-04-25 | 2017-02-16 | Berkeley Lights, Inc. | Dep force control and electrowetting control in different sections of the same microfluidic apparatus |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4962020A (en) | 1988-07-12 | 1990-10-09 | President And Fellows Of Harvard College | DNA sequencing |
US6565727B1 (en) | 1999-01-25 | 2003-05-20 | Nanolytics, Inc. | Actuators for microfluidics without moving parts |
EP1643231A1 (en) | 2003-07-09 | 2006-04-05 | Olympus Corporation | Device and method for carrying and treating liquid |
US20060153745A1 (en) | 2005-01-11 | 2006-07-13 | Applera Corporation | Fluid processing device for oligonucleotide synthesis and analysis |
PL1859330T3 (pl) | 2005-01-28 | 2013-01-31 | Univ Duke | Urządzenia i sposoby manipulacji kropelkami na płytkach obwodów drukowanych |
US8613889B2 (en) | 2006-04-13 | 2013-12-24 | Advanced Liquid Logic, Inc. | Droplet-based washing |
US8716015B2 (en) | 2006-04-18 | 2014-05-06 | Advanced Liquid Logic, Inc. | Manipulation of cells on a droplet actuator |
WO2008055256A2 (en) | 2006-11-02 | 2008-05-08 | The Regents Of The University Of California | Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip |
US20100120130A1 (en) | 2007-08-08 | 2010-05-13 | Advanced Liquid Logic, Inc. | Droplet Actuator with Droplet Retention Structures |
CN101945767B (zh) | 2007-12-23 | 2013-10-30 | 先进液体逻辑公司 | 液滴致动器配置以及引导液滴操作的方法 |
US8367370B2 (en) | 2008-02-11 | 2013-02-05 | Wheeler Aaron R | Droplet-based cell culture and cell assays using digital microfluidics |
KR100892905B1 (ko) * | 2008-02-27 | 2009-04-15 | 한국과학기술원 | 액적 구동장치 및 구동방법 |
US8852952B2 (en) | 2008-05-03 | 2014-10-07 | Advanced Liquid Logic, Inc. | Method of loading a droplet actuator |
FR2933713B1 (fr) | 2008-07-11 | 2011-03-25 | Commissariat Energie Atomique | Procede et dispositif de manipulation et d'observation de gouttes de liquide |
US9598725B2 (en) | 2010-03-02 | 2017-03-21 | Bio-Rad Laboratories, Inc. | Emulsion chemistry for encapsulated droplets |
WO2010151794A1 (en) | 2009-06-25 | 2010-12-29 | Purdue Research Foundation | Open optoelectrowetting droplet actuation device and method |
US20130288254A1 (en) | 2009-08-13 | 2013-10-31 | Advanced Liquid Logic, Inc. | Droplet Actuator and Droplet-Based Techniques |
EP2641097A4 (en) | 2010-11-17 | 2016-09-07 | CAPACITY RECOGNITION IN A DROPPER ACTUATOR | |
GB201217772D0 (en) | 2012-10-04 | 2012-11-14 | Base4 Innovation Ltd | Sequencing method |
GB201306444D0 (en) | 2013-04-09 | 2013-05-22 | Base4 Innovation Ltd | Single nucleotide detection method |
US20150306598A1 (en) * | 2014-04-25 | 2015-10-29 | Berkeley Lights, Inc. | DEP Force Control And Electrowetting Control In Different Sections Of The Same Microfluidic Apparatus |
GB201412977D0 (en) | 2014-07-22 | 2014-09-03 | Base4 Innovation Ltd | Single nucleotide detection method |
US10059922B2 (en) | 2014-07-31 | 2018-08-28 | Becton, Dickinson And Company | Methods and systems for separating components of a biological sample with gravity sedimentation |
DE102015106870B3 (de) | 2014-11-10 | 2016-02-25 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut | System zur Inkubation von mikrofluidischen Tropfen und Verfahren zur Bereitstellung von homogenen Inkubationsbedingungen in einer Tropfeninkubationseinheit |
EP3227025B1 (en) | 2014-12-05 | 2019-03-27 | The Regents of The University of California | Single-sided light-actuated microfluidic device with integrated mesh ground |
GB201501012D0 (en) | 2015-01-21 | 2015-03-04 | Base4 Innovation Ltd | Improved droplet sequencing apparatus and method |
GB201509640D0 (en) | 2015-06-03 | 2015-07-15 | Sphere Fluidics Ltd | Systems and methods |
CN105233887B (zh) * | 2015-08-31 | 2017-06-23 | 中国科学院深圳先进技术研究院 | 一种基于介电润湿的微液滴驱动器件及其制备方法 |
US10799865B2 (en) | 2015-10-27 | 2020-10-13 | Berkeley Lights, Inc. | Microfluidic apparatus having an optimized electrowetting surface and related systems and methods |
SG10202107069UA (en) * | 2015-10-27 | 2021-07-29 | Berkeley Lights Inc | Microfluidic electrowetting device apparatus having a covalently bound hydrophobic surface |
CN105413765A (zh) * | 2015-10-30 | 2016-03-23 | 北京航空航天大学 | 一种基于电润湿的共形光传感集成的数字微流芯片 |
US20180313819A1 (en) | 2017-04-26 | 2018-11-01 | Mike Joseph Pugia | High speed droplet sorter |
KR20240017985A (ko) * | 2017-06-21 | 2024-02-08 | 베이스4 이노베이션 엘티디 | 마이크로 액적 조작 장치 |
AU2018288533B2 (en) | 2017-06-21 | 2023-07-13 | Lightcast Discovery Ltd | Microfluidic analytical device |
-
2018
- 2018-06-21 KR KR1020247003426A patent/KR20240017985A/ko active Application Filing
- 2018-06-21 CA CA3067169A patent/CA3067169A1/en active Pending
- 2018-06-21 AU AU2018288532A patent/AU2018288532B2/en active Active
- 2018-06-21 CN CN201880041806.1A patent/CN110831697B/zh active Active
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- 2018-06-21 EP EP18732778.8A patent/EP3641934A1/en active Pending
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-
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- 2021-09-03 US US17/466,377 patent/US11904319B2/en active Active
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- 2022-11-02 JP JP2022176119A patent/JP7335415B2/ja active Active
-
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- 2023-11-01 AU AU2023258394A patent/AU2023258394A1/en active Pending
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005531409A (ja) * | 2002-05-31 | 2005-10-20 | ザ リージェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア | 光・電気濡れに基づくマイクロフルイディクスの光学的駆動のための装置と方法 |
JP2005030987A (ja) * | 2003-07-09 | 2005-02-03 | Olympus Corp | 液体搬送処理システム |
JP2006300946A (ja) * | 2005-04-19 | 2006-11-02 | Commissariat A L'energie Atomique | マイクロ流体の方法および質量を二種の不混和性相間で移送する装置 |
JP2009534653A (ja) * | 2006-04-18 | 2009-09-24 | アドバンスド・リキッド・ロジック・インコーポレイテッド | 液滴に基づく生化学 |
JP2010503516A (ja) * | 2006-05-09 | 2010-02-04 | アドバンスド・リキッド・ロジック・インコーポレイテッド | 液滴処置システム |
WO2010095577A1 (ja) * | 2009-02-17 | 2010-08-26 | 株式会社日立製作所 | 液滴微粒化装置 |
US20120044299A1 (en) * | 2009-08-14 | 2012-02-23 | Advanced Liquid Logic, Inc. | Droplet Actuator Devices and Methods |
JP2015527061A (ja) * | 2012-06-27 | 2015-09-17 | アドバンスト リキッド ロジック インコーポレイテッドAdvanced Liquid Logic, Inc. | 泡形成を低減するための技術および液滴アクチュエーターの設計 |
US20170043343A1 (en) * | 2014-04-25 | 2017-02-16 | Berkeley Lights, Inc. | Dep force control and electrowetting control in different sections of the same microfluidic apparatus |
US20160160259A1 (en) * | 2014-12-09 | 2016-06-09 | Berkeley Lights, Inc. | Automated detection of assay-positive areas in microfluidic devices |
JP2016153725A (ja) * | 2015-02-20 | 2016-08-25 | パナソニックIpマネジメント株式会社 | 液滴輸送装置の駆動方法 |
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US11904319B2 (en) | 2024-02-20 |
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US20230042172A1 (en) | 2023-02-09 |
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