JP2019112377A - Tooth stain adhesion inhibitor - Google Patents
Tooth stain adhesion inhibitor Download PDFInfo
- Publication number
- JP2019112377A JP2019112377A JP2017249384A JP2017249384A JP2019112377A JP 2019112377 A JP2019112377 A JP 2019112377A JP 2017249384 A JP2017249384 A JP 2017249384A JP 2017249384 A JP2017249384 A JP 2017249384A JP 2019112377 A JP2019112377 A JP 2019112377A
- Authority
- JP
- Japan
- Prior art keywords
- oil
- stain adhesion
- acid
- adhesion inhibitor
- iodine value
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
Description
本発明は、植物油を利用した歯のステイン付着抑制剤に関する。 The present invention relates to a tooth stain adhesion inhibitor using vegetable oil.
歯の着色汚れはステインと呼ばれており、歯面を覆っているアルブミンなどの口腔タンパク質の膜と飲食物由来の色素成分とが反応することにより形成されると考えられている。飲食物由来の色素成分としては、タンニン色素、クロロゲン酸等のポリフェノールが挙げられる。このような成分を含んだ食品は多々あるため、日常生活においてステインの原因の回避は困難であり、口腔審美における主要な問題の1つとなっている。 The stains on teeth are called stains, and are considered to be formed by the reaction of a film of an oral protein such as albumin covering the tooth surface with a pigment component derived from food and drink. Examples of pigment components derived from food and drink include polyphenols such as tannin pigment and chlorogenic acid. As there are many foods containing such ingredients, it is difficult to avoid the cause of stain in daily life, which is one of the major problems in oral esthetics.
口腔用組成物において、ステインの問題に対処するための処方が様々報告されている。ステインの問題へアプローチとしては、付着したステインの除去と、ステインの付着の抑制とが挙げられる。 In oral compositions, various formulations for addressing the problem of stain have been reported. Approaches to stain problems include the removal of attached stain and the suppression of stain attachment.
ステインの除去には、研磨剤による機械的手段、界面活性剤による化学的手段、及び酵素による生化学的手段が利用されている。一方、ステインの付着抑制には、例えば、特許文献1において、アシルアミノ酸塩、ノニオン型界面活性剤、ベタイン型両性界面活性剤及びアルキル硫酸塩を含有してなることを特徴とする歯磨組成物が提案されており;特許文献2において、カチオン性殺菌剤を含有する口腔用組成物に用いられ、2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体からなるステイン付着抑制剤が提案されており;特許文献3において、ピロリドンカルボン酸、6−オキソ−2−ピペリジンカルボン酸、3−(2−オキソ−1−アゼパニル)プロパン酸及びそれらの塩からなる群より選ばれる少なくとも1種のラクタム化合物、並びにフッ素化合物を含有する口腔用組成物が提案されている。 For removing stains, mechanical means with abrasives, chemical means with surfactants, and biochemical means with enzymes are used. On the other hand, in order to suppress adhesion of stains, for example, in Patent Document 1, a toothpaste composition comprising an acyl amino acid salt, a nonionic surfactant, a betaine amphoteric surfactant and an alkyl sulfate. Patent Document 2 proposes a stain adhesion inhibitor which is used in an oral composition containing a cationic bactericidal agent and which comprises 2-methacryloyloxyethyl phosphoryl choline / butyl methacrylate copolymer; In Patent Document 3, at least one lactam compound selected from the group consisting of pyrrolidone carboxylic acid, 6-oxo-2-piperidine carboxylic acid, 3- (2-oxo-1-azepanyl) propanoic acid and salts thereof, and An oral composition containing a fluorine compound has been proposed.
これまで報告されているステイン付着抑制剤は、それ自体ステイン付着抑制効果が充分でないか、又は処方に制限があるために近年の多様化する口腔用組成物の処方に対応できないケースがある。そこで、本発明は、ステイン付着抑制効果を有する新たな成分を提供することを目的とする。 The stain adhesion inhibitors that have been reported so far may not be able to cope with the recent diversified formulation of oral compositions due to insufficient stain adhesion inhibitory effect per se or limitations in formulation. Then, an object of this invention is to provide the new component which has a stain adhesion inhibitory effect.
本発明者は鋭意検討の結果、植物油にステイン付着抑制作用があることを見出した。本発明は、この知見に基づいてさらに検討を重ねることにより完成したものである。 As a result of intensive studies, the present inventor has found that vegetable oil has a stain adhesion inhibitory action. The present invention has been completed by further studies based on this finding.
即ち、本発明は、下記に掲げる態様の発明を提供する。
項1. 少なくとも1種の植物油からなる、歯のステイン付着抑制剤。
項2. 前記少なくとも1種の植物油のヨウ素価と含有量(重量%)との積の総和が、1 8050以下である、項1に記載の歯のステイン付着抑制剤。
項3. (A)ヨウ素価が190以下の植物油を主成分として含む、項1又は2に記載の歯のステイン付着抑制剤。
項4. 前記(A)成分のヨウ素価が65以上である、項3に記載の歯のステイン付着抑制剤。
項5. (B)ヨウ素価が65未満の植物油を副成分として含む、項4に記載の歯のステイン付着抑制剤。
項6. 項1〜5のいずれかに記載の歯のステイン付着抑制剤を含む、口腔用組成物。
That is, the present invention provides the invention of the aspects listed below.
Item 1. Tooth stain adhesion inhibitor comprising at least one vegetable oil.
Item 2. The tooth stain adhesion inhibitor according to Item 1, wherein the sum of the product of the iodine value and the content (% by weight) of the at least one vegetable oil is 18050 or less.
Item 3. The stain adhesion inhibitor for teeth according to Item 1 or 2, containing (A) a vegetable oil having an iodine value of 190 or less as a main component.
Item 4. Item 4. The tooth stain adhesion inhibitor according to item 3, wherein the iodine value of the component (A) is 65 or more.
Item 5. Item 5. The tooth stain adhesion inhibitor according to Item 4, comprising (B) a vegetable oil having an iodine value of less than 65 as a secondary component.
Item 6. An oral composition comprising the tooth stain adhesion inhibitor according to any one of items 1 to 5.
本発明によれば、ステイン付着抑制効果を有する新たな成分が提供される。 According to the present invention, a new component having a stain adhesion inhibitory effect is provided.
1.歯のステイン付着抑制剤
本発明の歯のステイン付着抑制剤は、少なくとも1種の植物油からなることを特徴とする。以下、本発明の歯のステイン付着抑制剤について詳述する。
1. Tooth Stain Adhesion Inhibitor The tooth stain adhesion inhibitor of the present invention is characterized by comprising at least one vegetable oil. Hereinafter, the stain adhesion inhibitor for teeth of the present invention will be described in detail.
植物油は、植物を原料とする油として公知の成分である。本発明においては、植物油が歯のステイン付着を抑制する作用を発揮する。植物油に含まれる成分は、主として脂肪酸トリグリセリドである。脂肪酸トリグリセリドを構成する脂肪酸としては、炭素数12〜24、好ましくは14〜24の飽和又は不飽和の脂肪酸であることが好ましく、具体的には、ラウリン酸、ミリスチン酸、パルミチン酸、パルミトレイン酸、ステアリン酸、オレイン酸、リノール酸、リノレン酸、アラキジン酸、エイコセン酸、ベヘン酸(ベヘニン酸)、エルカ酸(エルシン酸)、リグノセリン酸からなる群より選択される一種以上が挙げられる。 Vegetable oil is a component known as a plant-based oil. In the present invention, vegetable oil exerts an effect of suppressing stain adhesion of teeth. The ingredients contained in vegetable oils are mainly fatty acid triglycerides. The fatty acid constituting the fatty acid triglyceride is preferably a saturated or unsaturated fatty acid having 12 to 24 carbon atoms, preferably 14 to 24 carbon atoms. Specifically, lauric acid, myristic acid, palmitic acid, palmitoleic acid, One or more selected from the group consisting of stearic acid, oleic acid, linoleic acid, linolenic acid, arachidic acid, eicosenic acid, behenic acid (behenic acid), erucic acid (erucic acid) and lignoceric acid can be mentioned.
本発明で用いられる植物油の具体例としては特に限定されないが、例えば、ローズヒップ油、ひまわり油(ハイリノール油、中オレイン油、ハイオレイック油)、ホホバ油、コメヌカ油、オリブ油、マカデミアナッツ油、植物性スクワラン、ヤシ油、エゴマ油、イチゴ種子油、月見草油、サフラワー油、コムギ胚芽油、大豆油、キューカンバー油、トウモロコシ油、ゴマ油、綿実油、ラッカセイ油、メドウフォーム油、アボカド油、ヘーゼルナッツ油、ヒマシ油、ツバキ油、シアバター、アニス油、アルモンド油、オレンジラフィー油、カミツレ油、キョウニン油、スペアミント油、チョウジ油、テレピン油、バーシック油、パーム油、ハッカ油、ユーカリ油が挙げられる。これらの植物油は、1種又は2種以上を組み合わせて用いることができる。 Specific examples of the vegetable oil used in the present invention are not particularly limited. For example, rosehip oil, sunflower oil (hylinol oil, medium olein oil, higholeic oil), jojoba oil, rice bran oil, olive oil, macadamia nut oil, plant Squalane, Coconut Oil, Sesame Seed Oil, Strawberry Seed Oil, Evening Primrose Oil, Safflower Oil, Wheat Germ Oil, Soy Bean Oil, Cucumber Oil, Corn Oil, Sesame Oil, Sesame Oil, Cotton Seed Oil, Peanut Oil, Meadow Foam Oil, Avocado Oil, Hazelnut Oil, Castor oil, camellia oil, shea butter, anise oil, almond oil, orange raffe oil, chamomile oil, kyonine oil, spearmint oil, clove oil, turpentine oil, versic oil, palm oil, peppermint oil, eucalyptus oil. These vegetable oils can be used alone or in combination of two or more.
本発明の歯のステイン付着抑制剤の組成としては、本発明の歯のステイン付着抑制効果を良好に得る観点から、ヨウ素価と含有量(歯のステイン付着抑制剤中における割合(%))との積の総和として、例えば18050以下、好ましくは12600以下が挙げられ、より好ましくは9000以下、さらに好ましくは8500となる組成が挙げられる。ヨウ素価と含有量との積の総和は、その下限において特に限定されるものではないが、歯のステイン付着抑制効果をより良好に得る観点から、例えば200以上、好ましくは900以上、より好ましくは3250以上、さらに好ましくは5000以上が挙げられる。 The composition of the stain adhesion inhibitor of the present invention has an iodine value and a content (proportion (%) in the stain adhesion inhibitor of the tooth) from the viewpoint of favorably obtaining the stain adhesion inhibitory effect of the tooth of the present invention. As the sum of the products of the above, for example, a composition of 18050 or less, preferably 12600 or less is mentioned, more preferably 9000 or less, still more preferably 8500. The total sum of the product of the iodine number and the content is not particularly limited at the lower limit thereof, but is, for example, 200 or more, preferably 900 or more, more preferably from the viewpoint of obtaining the stain adhesion suppressing effect of teeth better. 3250 or more, More preferably, 5000 or more are mentioned.
本発明の歯のステイン付着抑制剤は、歯のステイン付着抑制効果を良好に得る観点から、(A)ヨウ素価が190以下の植物油(以下において、(A)成分と記載することがある。)を主成分として含むことが好ましい。ここで、主成分とは、歯のステイン付着抑制剤の50重量%超を占める成分をいう。(A)成分は、歯のステイン付着抑制効果をより良好に得る観点から、ヨウ素価として、好ましくは150以下、より好ましくは130以下、さらに好ましくは110以下のものが挙げられる。このような植物油としては、ローズヒップ油、ひまわり油(ハイリノール油、中オレイン油、ハイオレイック油)、ホホバ油、コメヌカ油、オリブ油、マカデミアナッツ油、植物性スクワラン、ヤシ油、イチゴ種子油、月見草油、サフラワー油、コムギ胚芽油、大豆油、キューカンバー油、トウモロコシ油、ゴマ油、綿実油、ラッカセイ油、メドウフォーム油、アボカド油、ヘーゼルナッツ油、ヒマシ油、ツバキ油、シアバター、アニス油、アルモンド油、オレンジラフィー油、カミツレ油、キョウニン油、スペアミント油、チョウジ油、テレピン油、バーシック油、パーム油、ハッカ油、ユーカリ油が挙げられ;好ましくは、ひまわり油、ホホバ油、コメヌカ油、オリブ油、マカデミアナッツ油、植物性スクワラン、ヤシ油、サフラワー油、コムギ胚芽油、大豆油、キューカンバー油、トウモロコシ油、ゴマ油、綿実油、ラッカセイ油、メドウフォーム油、アボカド油、ヘーゼルナッツ油、ヒマシ油、ツバキ油、シアバターが挙げられ;さらに好ましくは、ひまわり油(中オレイン油、ハイオレイック油)、ホホバ油、コメヌカ油、オリブ油、マカデミアナッツ油、植物性スクワラン、ヤシ油、キューカンバー油、トウモロコシ油、ゴマ油、綿実油、ラッカセイ油、メドウフォーム油、アボカド油、ヘーゼルナッツ油、ヒマシ油、ツバキ油、シアバターが挙げられる。 The stain adhesion inhibitor for teeth of the present invention is a vegetable oil (A) having an iodine value of 190 or less (hereinafter, may be described as a component (A)) from the viewpoint of obtaining a stain adhesion inhibition effect of teeth favorably. It is preferable to contain as a main component. Here, the main component means a component that accounts for more than 50% by weight of the stain adhesion inhibitor for teeth. The component (A) preferably has an iodine value of 150 or less, more preferably 130 or less, and still more preferably 110 or less, as an iodine value, from the viewpoint of obtaining the stain adhesion inhibitory effect on teeth better. Such vegetable oils include rosehip oil, sunflower oil (high linoleum oil, medium olein oil, high oleic oil), jojoba oil, rice bran oil, olive oil, macadamia nut oil, vegetable squalane, coconut oil, strawberry seed oil, evening primrose Oil, safflower oil, wheat germ oil, soybean oil, cucumber oil, corn oil, sesame oil, cottonseed oil, peanut oil, meadowfoam oil, avocado oil, hazelnut oil, castor oil, castor oil, camellia oil, shea butter, anise oil, almond oil Orange raffi oil, chamomile oil, saponin oil, spearmint oil, clove oil, turpentine oil, versic oil, palm oil, peppermint oil, eucalyptus oil, preferably sunflower oil, jojoba oil, rice bran oil, olive oil, Macadamia nut oil, vegetable squalane, coconut oil, safflower oil Wheat germ oil, soybean oil, cucumber oil, corn oil, sesame oil, cottonseed oil, peanut oil, meadowfoam oil, avocado oil, hazelnut oil, castor oil, camellia oil, shea butter, and the like; Olein oil, high oleic oil), jojoba oil, rice bran oil, olive oil, macadamia nut oil, vegetable squalane, coconut oil, cucumber oil, corn oil, sesame oil, sesame seed oil, cottonseed oil, peanut oil, meadowfoam oil, avocado oil, hazelnut oil, castor oil Oil, camellia oil, shea butter.
(A)成分は、歯のステイン付着抑制効果をさらに良好に得る観点から、ヨウ素価として、好ましくは20以上、より好ましくは65以上のものが挙げられる。このような植物油としては、ローズヒップ油、ひまわり油、ホホバ油、コメヌカ油、オリブ油、マカデミアナッツ油、エゴマ油、イチゴ種子油、月見草油、サフラワー油、コムギ胚芽油、大豆油、キューカンバー油、トウモロコシ油、ゴマ油、綿実油、ラッカセイ油、メドウフォーム油、アボカド油、ヘーゼルナッツ油、ヒマシ油、ツバキ油、シアバター、アニス油、アルモンド油、オレンジラフィー油、カミツレ油、キョウニン油、スペアミント油、チョウジ油、テレピン油、バーシック油、パーム油、ハッカ油、ユーカリ油が挙げられ;好ましくは、ひまわり油、ホホバ油、コメヌカ油、オリブ油、マカデミアナッツ油、エゴマ油、イチゴ種子油、月見草油、サフラワー油、コムギ胚芽油、大豆油、キューカンバー油、トウモロコシ油、ゴマ油、綿実油、ラッカセイ油、メドウフォーム油、アボカド油、ヘーゼルナッツ油、ヒマシ油、ツバキ油、シアバターが挙げられ;さらに好ましくは、ひまわり油(中オレイン油、ハイオレイック油)、ホホバ油、コメヌカ油、オリブ油、マカデミアナッツ油、エゴマ油、イチゴ種子油、月見草油、サフラワー油、コムギ胚芽油、大豆油、キューカンバー油、トウモロコシ油、ゴマ油、綿実油、ラッカセイ油、メドウフォーム油、アボカド油、ヘーゼルナッツ油、ヒマシ油、ツバキ油が挙げられる。 The component (A) preferably has an iodine number of 20 or more, more preferably 65 or more, as an iodine value, from the viewpoint of obtaining the stain adhesion inhibitory effect on teeth more favorably. Such vegetable oils include rosehip oil, sunflower oil, jojoba oil, rice bran oil, olive oil, macadamia nut oil, sesame oil, strawberry seed oil, evening primrose oil, safflower oil, wheat germ oil, soybean oil, cucumber oil, Corn oil, sesame oil, cottonseed oil, peanut oil, meadowfoam oil, avocado oil, hazelnut oil, castor oil, castor oil, camellia oil, shea butter, anise oil, almond oil, orange ruffy oil, camomile oil, pomegranate oil, spearmint oil, clove oil Preferably, sunflower oil, jojoba oil, rice bran oil, olive oil, macadamia nut oil, sesame seed oil, strawberry seed oil, evening primrose oil, safflower oil , Wheat germ oil, soybean oil, cucumber oil, corn oil, Maize oil, cottonseed oil, peanut oil, meadowfoam oil, avocado oil, hazelnut oil, castor oil, camellia oil, camel butter, shea butter are more preferable; sunflower oil (medium olein oil, high oleic oil), jojoba oil, rice bran oil , Olive oil, macadamia nut oil, sesame seed oil, strawberry seed oil, evening primrose oil, safflower oil, wheat germ oil, soybean oil, cucumber oil, corn oil, sesame oil, sesame seed oil, cottonseed oil, peanut oil, meadowfoam oil, avocado oil, hazelnut oil , Castor oil and camellia oil.
本発明の歯のステイン付着抑制剤は、(A)成分のヨウ素価が65以上である場合、歯のステイン付着抑制効果をさらに良好に得る観点から、(A)成分に、(B)ヨウ素価が65未満の植物油(以下、(B)成分と記載することがある)を副成分として組み合わせることがより好ましい。(B)成分は、単独では歯のステイン付着抑制効果が(A)成分に劣るものの、(A)成分と組み合わせることで、相乗的に歯のステイン付着抑制効果を向上させることができる。(B)成分として用いられる植物油としては、植物性スクワラン、ヤシ油、シアバターが挙げられる。 The stain adhesion inhibitor for teeth of the present invention, when the iodine value of the component (A) is 65 or more, from the viewpoint of obtaining the stain adhesion inhibitory effect on teeth better, the component (A) contains (B) iodine value It is more preferable to combine a vegetable oil of less than 65 (hereinafter sometimes referred to as component (B)) as a secondary component. Although the component (B) alone is inferior to the component (A) in the stain adhesion inhibitory effect of teeth, the stain adhesion inhibitory effect on teeth can be synergistically improved by combining with the component (A). As vegetable oil used as (B) component, vegetable squalane, coconut oil, and shea butter are mentioned.
本発明の歯のステイン付着抑制剤が(B)成分を含む場合、(B)成分の含有量は、(A)成分による歯のステイン付着抑制効果をより効果的に向上させる観点から、例えば5重量%以上、好ましくは10重量%以上、より好ましくは15重量%以上が挙げられる。(B)成分の含有量は、その上限値において、副成分である限度(つまり50重量%未満)において特に限定されないが、好ましくは40重量%以下、より好ましくは30重量%以下が挙げられる。 When the stain adhesion inhibitor of the tooth of the present invention contains the component (B), the content of the component (B) is, for example, 5 from the viewpoint of more effectively improving the stain adhesion suppression effect of the tooth by the component (A). % By weight or more, preferably 10% by weight or more, more preferably 15% by weight or more. The content of the component (B) at the upper limit thereof is not particularly limited in the limit (that is, less than 50% by weight) which is a secondary component, but preferably 40% by weight or less, more preferably 30% by weight or less.
なお、ヨウ素価は、医薬部外品原料規格2006,一般試験法,ヨウ素価測定法に従って測定した値である。 The iodine value is a value measured according to the quasi-drug raw material standard 2006, the general test method, and the iodine value measurement method.
植物油は、薬理学的又は生理学的に許容されるものであれば、特に制限されない。例えば、公知の搾取方法や公知の精製方法を用いて種子等の植物の部分から得たもの、及び市販のものが挙げられる。特に、歯のステイン付着抑制効果を良好に得る観点から、日本農林規格又は日本薬局方の規格に適合する植物油が好適である。 The vegetable oil is not particularly limited as long as it is pharmacologically or physiologically acceptable. For example, those obtained from parts of plants such as seeds using known squeezing methods and known smelting methods, and those commercially available may be mentioned. In particular, from the viewpoint of favorably obtaining the stain adhesion suppressing effect of teeth, a vegetable oil conforming to the Japanese Agricultural Standard or the Japanese Pharmacopoeia standard is preferable.
2.口腔用組成物
本発明の口腔用組成物は、上述の歯のステイン付着抑制剤を含むことを特徴とする。本発明の口腔用組成物において、歯のステイン付着抑制剤の含有量は特に限定されないが、歯のステイン付着抑制を効果的に得る観点から、例えば10重量%以上、好ましくは30重量%以上、より好ましくは50重量%以上が挙げられる。歯のステイン付着抑制剤の含有量は、口腔用組成物の製剤形態に応じて許容可能である限り、その上限において特に限定されるものではないが、例えば95重量%以下、好ましくは90重量%以下が挙げられる。
2. Oral Composition The oral composition of the present invention is characterized by containing the above-mentioned tooth stain adhesion inhibitor. In the composition for oral cavity of the present invention, the content of the stain adhesion inhibitor of the tooth is not particularly limited, but from the viewpoint of effectively obtaining the stain adhesion suppression of the tooth, for example, 10% by weight or more, preferably 30% by weight or more, More preferably, it is 50% by weight or more. The content of the tooth stain adhesion inhibitor is not particularly limited at its upper limit as long as it is acceptable depending on the formulation form of the composition for oral cavity, but it is for example 95 wt% or less, preferably 90 wt% The following can be mentioned.
その他の成分
本発明の口腔用組成物は、前述する成分以外に、本発明の効果を損なわない範囲で、口腔用組成物の製剤形態に応じて、当該技術分野で通常使用される成分を含有していてもよい。このような成分としては、例えば、防腐剤、殺菌剤、抗菌剤、消炎剤、研磨剤、グルコシルトランスフェラーゼ(GTase)阻害剤、プラーク抑制剤、知覚過敏抑制剤、歯石予防剤、歯質強化/再石灰化剤、抗ヒスタミン剤、局所麻酔剤、血行促進剤、増粘剤、湿潤剤、賦形剤、香料、甘味剤、清涼化剤、色素、消臭剤、界面活性剤、溶剤、pH調整剤等が挙げられる。
Other Components The composition for oral cavity of the present invention contains, in addition to the components described above, components generally used in the technical field according to the formulation form of the composition for oral cavity as long as the effects of the present invention are not impaired It may be done. Such components include, for example, preservatives, bactericides, antibacterial agents, anti-inflammatory agents, abrasives, glucosyl transferase (GTase) inhibitors, plaque inhibitors, hypersensitivity inhibitors, anti-calculus agents, dentinosis / regeneration. Mineralizer, antihistamine, local anesthetic, circulation enhancer, thickener, wetting agent, excipient, flavor, sweetener, refreshing agent, pigment, deodorant, surfactant, solvent, pH adjuster, etc. Can be mentioned.
防腐剤、殺菌剤、抗菌剤としては、例えば、ヒノキチオール、安息香酸類、サリチル酸類、ソルビン酸類、パラベン類、塩化デカリニウム、塩化クロルヘキシジン、グルコン酸クロルヘキシジン、イソプロピルメチルフェノール、トリクロサン、塩化リゾチーム、塩酸クロルヘキシジン、ヨウ化カリウム等が挙げられる。 Examples of preservatives, bactericidal agents and antibacterial agents include hinokitiol, benzoic acids, salicylic acids, sorbic acids, parabens, decarinium chloride, chlorhexidine chloride, chlorhexidine gluconate, isopropylmethylphenol, triclosan, lysozyme chloride, chlorhexidine hydrochloride, iodine Potassium iodide and the like.
消炎剤としては、例えば、グリチルリチン酸ジカリウム、グリチルレチン酸、グリチルリチン酸メチル、グリチルリチン酸ステアリル、グリチルレチン酸ピリドキシン、グリチルレチン酸ステアリル、グリチルレチン酸グリセリル、グリチルレチン酸モノグルクロニド、アラントイン、トラネキサム酸、イプシロンアミノカプロン酸、アズレン、塩化ナトリウム、ビタミン類等が挙げられる。 Examples of anti-inflammatory agents include dipotassium glycyrrhizinate, glycyrrhetinic acid, methyl glycyrrhizinate, stearyl glycyrrhizinate, pyridoxine glycyrrhetinate, stearyl glycyrrhetinate, glyceryl glycyrrhetinate, monoglucuronide glycyrrhetinate, allantoin, tranexamic acid, epsilon aminocaproate, Sodium chloride, vitamins and the like can be mentioned.
研磨剤としては、例えば、無水ケイ酸、含水ケイ酸、酸化アルミニウム、水酸化アルミニウム、リン酸水素カルシウム、リン酸カルシウム、ピロリン酸カルシウム、炭酸カルシウム、結晶セルロース、ポリエチレン末、炭粒等が挙げられる。 Examples of the abrasive include anhydrous silicic acid, hydrous silicic acid, aluminum oxide, aluminum hydroxide, calcium hydrogen phosphate, calcium phosphate, calcium pyrophosphate, calcium carbonate, crystalline cellulose, polyethylene powder, carbon particles and the like.
GTase阻害剤としては、例えば、アカバナ科マツヨイグサ属植物の抽出物、ブドウ科ブドウ属植物の抽出物、デキストラナーゼ、ムタナーゼ、タステイン、タンニン類、エラグ酸、ポリフェノール、ウーロン茶抽出物、緑茶抽出物、センブリ、タイソウ、ウイキョウ、芍薬、ゲンチアナ、センソ、龍胆、黄連等が挙げられる。 As a GTase inhibitor, for example, an extract of a plant belonging to the genus Pinus vulgare L., an extract of Vitis vines, a dextranase, mutanase, tastein, tannins, ellagic acid, polyphenol, oolong tea extract, green tea extract, There are Semburi, Taisou, fennel, glaze, gentiana, senso, long-bowl, Huangren, etc.
プラーク抑制剤としては、例えばクエン酸亜鉛やグルコン酸等が挙げられる。 Examples of the plaque inhibitor include zinc citrate and gluconic acid.
知覚過敏抑制剤としては、例えば、硝酸カリウム、塩化ストロンチウム等が挙げられる。 Examples of the hypersensitivity suppressor include potassium nitrate, strontium chloride and the like.
歯石予防剤としては、例えば、ポリリン酸塩類、ゼオライト、エタンヒドロキシジホスフォネート等が挙げられる。 As an anti-calculus agent, for example, polyphosphates, zeolite, ethane hydroxy diphosphonate and the like can be mentioned.
歯質強化/再石灰化剤としては、例えば、フッ素、フッ化ナトリウム、フルオロリン酸ナトリウム、フッ化第一スズ等が挙げられる。 Examples of the tooth strengthening / remineralizing agent include fluorine, sodium fluoride, sodium fluorophosphate and stannous fluoride.
抗ヒスタミン剤としては、例えば、ジフェンヒドラミン、塩酸ジフェンヒドラミン等が挙げられる。 Examples of antihistamines include diphenhydramine, diphenhydramine hydrochloride and the like.
局所麻酔剤としては、例えば、プロカイン、テトラカイン、ブピパカイン、メピパカイン、クロロプロカイン、プロパラカイン、メプリルカイン又はこれらの塩、オルソカイン、オキセサゼイン、オキシポリエントキシデカン、ロートエキス、ペルカミンパーゼ、テシットデシチン等が挙げられる。 The local anesthetic includes, for example, procaine, tetracaine, bupipakine, mepipacain, chlorprocaine, proparacaine, meprilcain or salts thereof, orthokine, oxesazein, oxypolyentoxydecane, roto extract, percamine pase, tesitdectin and the like.
血行促進剤としては、例えば、ノニル酸ワニリルアミド、ニコチン酸ベンジルエステル、カプサイシン、トウガラシエキス等が挙げられる。 Examples of the blood circulation promoting agent include nonylic acid allirylamide, nicotinic acid benzyl ester, capsaicin, pepper extract and the like.
増粘剤としては、例えば、プルラン、プルラン誘導体、デンプン等の多糖類;ヒドロキシプロピルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルメチルセルロース、ヒドロキシエチルメチルセルロース、カルボキシメチルセルロース、カルボキシメチルセルロース塩類(カルボキシメチルセルロースナトリウム、カルボキシメチルセルロースカリウム等)、メチルセルロース、エチルセルロース、ポリアクリル酸、ポリアクリル酸塩(ポリアクリル酸ナトリウム、アクリル酸・アクリル酸オクチルエステル共重合体等)、メタアクリル酸類の共重合体(メタアクリル酸とアクリル酸 n−ブチルの重合体、メタアクリル酸とメタアクリル酸メチルの重合体及びメタアクリル酸とアクリル酸エチルの重合体等)等のセルロース系高分子物質;カルボキシビニルポリマー、ポリエチレングリコール、ポリビニルアルコール、ポリビニルピロリドン等の合成高分子物質;レクチン、アルギン酸、アルギン酸塩(アルギン酸ナトリウム、アルギン酸カリウム、アルギン酸マグネシウム、アルギン酸プロピレングリコールエステル、アルギン酸トリエタノールアミン、アルギン酸トリイソプロパノールアミン、アルギン酸アンモニウム、アルギン酸ブチルアミン、アルギン酸ジアミルアミン等)、コンドロイチン硫酸ナトリウム、寒天、キトサン、カラギーナン等の天然系高分子物質;コラーゲン、ゼラチン等のアミノ酸系高分子物質;アラビアガム、カラヤガム、トラガカントガム、キサンタンガム、ローカストビーンガム、グアガム、タマリンドガム、ジェランガム等のゴム系高分子物質等が挙げられる。 As the thickener, for example, polysaccharides such as pullulan, pullulan derivatives, starch and the like; hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose, hydroxyethyl methylcellulose, carboxymethyl cellulose, carboxymethyl cellulose salts (sodium carboxymethylcellulose, potassium carboxymethylcellulose etc.) , Methylcellulose, ethylcellulose, polyacrylic acid, polyacrylate (sodium polyacrylate, acrylic acid / acrylic acid octyl ester copolymer, etc.), methacrylic acid copolymers (methacrylic acid and n-butyl acrylate) Polymers, polymers of methacrylic acid and methyl methacrylate, polymers of methacrylic acid and ethyl acrylate, etc.) Polymeric substances; Synthetic polymeric substances such as carboxyvinyl polymer, polyethylene glycol, polyvinyl alcohol, polyvinyl pyrrolidone, etc .; Lectin, alginic acid, alginate (sodium alginate, potassium alginate, magnesium alginate, propylene glycol alginate, triethanolamine alginate, alginate Natural polymeric substances such as triisopropanolamine, ammonium alginate, butylamine alginic acid, diamylamine alginic acid sodium, chondroitin sulfate sodium, agar, chitosan, carrageenan, etc .; amino acid type polymeric substances such as collagen, gelatin; gum arabic, karaya gum, tragacanth gum, Xanthan gum, locust bean gum, guar gum, tamarind gum, gellan gum, etc. System polymer material, and the like.
湿潤剤としては、例えば、グリセリン、ソルビトール、エチレングリコール、プロピレングリコール、ポリエチレングリコール、ポリプロピレングリコール、キシリトール、マルチトール、ラクトール、エリスリトール等が挙げられる。 As the humectant, for example, glycerin, sorbitol, ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactol, erythritol and the like can be mentioned.
賦形剤としては、例えば、乳糖、白糖、マンニトール、デンプン、デキストリン、結晶セルロース、シリカ(軽質無水ケイ酸等)等が挙げられる。 Examples of the excipient include lactose, sucrose, mannitol, starch, dextrin, crystalline cellulose, silica (light anhydrous silicic acid etc.) and the like.
香料としては、例えば、天然香料(ウイキョウ油等)、合成香料、これらの調合香料等が挙げられる。 Examples of the fragrant include natural fragrant (such as fennel oil), synthetic fragrant, and blended fragrants thereof.
甘味剤としては、サッカリンナトリウム、ステビオサイド、ステビアエキス、アスパルテーム、キシリトール、水飴、蜂蜜、ソルビトール、マルチトール、マンニトール、エリスリトール、糖類(乳糖、白糖、果糖、ブドウ糖等)等が挙げられる。 As the sweetening agent, saccharin sodium, stevioside, stevia extract, aspartame, xylitol, starch syrup, honey, sorbitol, maltitol, mannitol, erythritol, saccharides (lactose, sucrose, fructose, glucose, etc.) and the like can be mentioned.
清涼化剤としては、例えば、メントール、エリスリトール、カンフル、ボルネオール、ゲラニオール、これらを含む精油等が挙げられる。 Examples of the refreshing agent include menthol, erythritol, camphor, borneol, geraniol, essential oils containing these, and the like.
色素としては、例えば、天然色素、合成色素、これらの混合物が挙げられる。 The dyes include, for example, natural dyes, synthetic dyes, and mixtures thereof.
消臭剤としては、例えば、塩化亜鉛、銅クロロフィリンナトリウム、コーヒー生豆抽出物、ゴボウパウダー、緑茶、焙煎米糠エキス等が挙げられる。 Examples of the deodorant include zinc chloride, sodium copper chlorophyllin, green coffee bean extract, burdock powder, green tea, roasted rice bran extract and the like.
界面活性剤としては、例えば、ポリオキシエチレンラウリルエーテル硫酸ナトリウム、ラウリル硫酸ナトリウム、ミリスチル硫酸ナトリウム、N−ラウロイルサルコシン酸ナトリウム、N−ミリストリルサルコシン酸ナトリウム、ドデシルベンゼンスルホン酸ナトリウム、水素添加ココナッツ脂肪酸モノグリセリドモノ硫酸ナトリウム、ラウリルスルホ酢酸ナトリウム、α−オレフィンスルホン酸ナトリウム、N−パルミトイルグルタルミン酸ナトリウム、N−メチル−N−アシルタウリンナトリウム等の陰イオン性界面活性剤;ポリオキシエチレン硬化ヒマシ油、ショ糖脂肪酸エステル、マルトース脂肪酸エステル、マルチトール脂肪酸エステル、ラクトール脂肪酸エステル、ソルビタン脂肪酸エステル、ポリオキシエチレンソルビタンモノステアレート、ポリオキシエチレン高級アルコールエーテル、ポリオキシエチレンポリオキシプロピレン共重合体、ポリオキシエチレンポリオキシプロピレン脂肪酸エステル、ポリグリセリン脂肪酸エステル等の非イオン性界面活性剤;ヤシ油脂肪酸アミドプロピルベタイン、ラウリルジメチルアミノ酢酸ベタイン、ラウリルジメチルアミンオキシド、2-アルキル−N−カルボキシメチル−N−ヒドロキシエチルイミダゾリウムベタイン、N−ラウリルジアミノエチルグリシン、N−ミリスチルジアミノエチルグリシン、N−アルキル−1−ヒドロキシエチルイミダゾリンベタインナトリウム等の両性界面活性剤;塩化ラウリルトリメチルアンモニウム、塩化ステアリルトリメチルアンモニウム、塩化ベンゼトニウム、塩化ベンザルコニウム、塩化ステアリルジメチルベンジルアンモニウム等の陽イオン性界面活性剤が挙げられる。 As the surfactant, for example, sodium polyoxyethylene lauryl ether sulfate, sodium lauryl sulfate, sodium myristyl sulfate, sodium N-lauroyl sarcosinate, sodium N-myristryl sarcosinate, sodium dodecyl benzene sulfonate, hydrogenated coconut fatty acid monoglyceride Anionic surfactants such as sodium monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, sodium N-palmitoylglutarate, sodium N-methyl-N-acyl taurine, etc .; polyoxyethylene hydrogenated castor oil, Sugar fatty acid ester, maltose fatty acid ester, maltitol fatty acid ester, lactol fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan mo Nonionic surfactants such as stearate, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester, polyglycerin fatty acid ester; coconut oil fatty acid amidopropyl betaine, lauryl Dimethylaminoacetic acid betaine, lauryldimethylamine oxide, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-lauryldiaminoethylglycine, N-myristyldiaminoethylglycine, N-alkyl-1-hydroxyethylimidazoline Amphoteric surfactants such as betaine sodium; lauryltrimethylammonium chloride, stearyltrimethylammonium chloride, benzethonium chloride, benzalkonium chloride , Cationic surfactants such as chloride stearyl dimethyl benzyl ammonium.
溶剤としては、例えば、水、エタノール、プロパノール、ブタノール、ペンタノール、ヘキサノール、イソプロパノール等の1価アルコール等が挙げられる。 Examples of the solvent include water, ethanol, propanol, butanol, pentanol, hexanol, monohydric alcohols such as isopropanol, and the like.
pH調整剤としては、例えば、酢酸、塩酸、硫酸、硝酸、クエン酸、リンゴ酸、乳酸、リン酸、安息香酸、水酸化ナトリウム、水酸化カリウム、酢酸ナトリウム、炭酸ナトリウム、クエン酸ナトリウム、クエン酸水素ナトリウム、乳酸ナトリウム、乳酸カルシウム、リン酸ナトリウム、リン酸水素ナトリウム、安息香酸ナトリウム等が挙げられる。 As a pH adjuster, for example, acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, malic acid, lactic acid, phosphoric acid, benzoic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium acetate, sodium carbonate, sodium citrate, citric acid Examples include sodium hydrogen, sodium lactate, calcium lactate, sodium phosphate, sodium hydrogen phosphate, sodium benzoate and the like.
本発明の口腔用組成物において、これらの成分を含有させる場合、その含有量については、当該技術分野で通常使用される範囲で適宜設定すればよい。 In the composition for oral cavity of the present invention, when these components are contained, the content thereof may be appropriately set in the range generally used in the relevant technical field.
pH
また、本発明の口腔用組成物のpHについては、口腔内への適用が許容される範囲で適宜設定すればよいが、例えば、4〜8、好ましくは5〜7.5、更に好ましくは6〜7が挙げられる。ここで、pHとは、25℃の温度条件下で測定される値である。
pH
In addition, the pH of the composition for oral cavity of the present invention may be appropriately set in the range in which application to the oral cavity is permitted, and for example, 4 to 8, preferably 5 to 7.5, and more preferably 6 -7 are mentioned. Here, pH is a value measured under a temperature condition of 25 ° C.
製剤形態
本発明の口腔用組成物の形状については、特に制限されず、液状、固形状、半固形状(ゲル状、軟膏状、ペースト状)等のいずれであってもよい。
Formulation Form The shape of the composition for oral cavity of the present invention is not particularly limited, and may be liquid, solid, semi-solid (gel, ointment, paste) and the like.
本発明の口腔用組成物は、口腔内に適用されて口腔内で一定時間滞留し得るものである限り、可食性、非可食性の別を問わない。本発明の口腔用組成物は、例えば、口腔衛生剤、食品(機能性食品、健康保健用食品、病者用食品等を含む)、医薬品(医薬部外品を含む)、化粧品等のいずれの形態であってもよい。本発明の口腔用組成物の製剤形態として、具体的には、液体歯磨剤、練歯磨剤、潤製歯磨剤、粉歯磨剤、洗口剤(マウスウォッシュ)、マウスリンス、含嗽剤、口中清涼剤(マウススプレー等)、口腔用パスタ剤、歯肉マッサージクリーム、口腔咽候薬(トローチ剤等)等の口腔衛生剤;可食性フィルム、チューインガム、キャンディ、グミキャンディ、タブレット、顆粒、細粒、粉末、カプセル等の可食性口腔用剤等が挙げられる。これらの中でも、口腔衛生剤は、口腔粘膜に対して、前記(A)及び(B)成分に基づく炎症や出血を抑制する作用を付与し易く、好適な製剤形態である。口腔衛生剤の中でも、好ましくは液体歯磨剤、練歯磨剤、潤製歯磨剤、洗口剤が挙げられる。 The composition for oral cavity of the present invention may be edible or non-edible, as long as it can be applied in the oral cavity and stay in the oral cavity for a certain period of time. The composition for oral cavity of the present invention is, for example, any of oral hygiene agents, foods (including functional foods, foods for health and health care, foods for sick people etc.), medicines (including quasi-drugs), cosmetics, etc. It may be in the form. Specifically, the dosage form of the composition for oral cavity according to the present invention includes liquid dentifrice, toothpaste, moisturizing dentifrice, powder dentifrice, mouthwash (mouthwash), mouthrinse, mouthwash, mouth rinse Hygiene agents such as mouth spray (mouth spray etc.), oral pasta preparation, gum massage cream, oropharyngeal medicine (troche etc); edible film, chewing gum, candy, gummy candy, tablets, granules, fine particles, powder And edible oral preparations such as capsules. Among these, the oral hygiene agent can easily impart an action to suppress inflammation and bleeding based on the components (A) and (B) on the oral mucosa, and is a suitable preparation form. Among oral hygiene agents, preferred are liquid dentifrices, toothpastes, moisturizers and mouthrinses.
製造方法
本発明の口腔用組成物は、前述する歯のステイン付着抑制剤、及び必要に応じて配合される他の成分を配合して、その製剤形態に応じた所定の形状に調製することによって製造できる。
Manufacturing method The composition for oral cavity of the present invention is prepared by blending the above-mentioned tooth stain adhesion inhibitor and other components optionally blended, and preparing it into a predetermined shape according to the formulation form. It can be manufactured.
用途
本発明の口腔用組成物は、歯のステイン付着抑制を目的として使用することができる。具体的には、飲食の後又は前に使用することができ、好ましくは、飲食の前に使用することができる。例えば歯磨きやうがいの後に、タンニン色素、クロロゲン酸等のポリフェノールを含む飲料等を摂取する場合などに特に好適に用いられる。
Applications The oral composition of the present invention can be used for the purpose of inhibiting stain adhesion of teeth. Specifically, it can be used after or before eating and drinking, preferably before eating and drinking. For example, it is particularly suitably used, for example, when taking in a drink containing tannin pigment and polyphenol such as chlorogenic acid after tooth brushing and gargle.
以下に実施例を示して本発明をより具体的に説明するが、本発明はこれらに限定されるものではない。なお、以下において用いた植物油の詳細は表1に示す通りである。表1に示す植物油のヨウ素価は、医薬部外品原料規格2006,一般試験法,ヨウ素価測定法に従って測定した値である。 EXAMPLES The present invention will be more specifically described below by way of Examples, but the present invention is not limited thereto. In addition, the detail of the vegetable oil used below is as showing in Table 1. The iodine value of the vegetable oil shown in Table 1 is a value measured according to the quasi-drug raw material standard 2006, the general test method, and the iodine value measurement method.
[試験例1]
以下のようにして、ステイン溶液を調製した。
約600mLの熱湯に紅茶ティーバッグ(ユニリーバ・ジャパン株式会社製;商品名サー・トーマス・リプトン)2袋を加え、10分間沸騰させた。室温まで冷却後、インスタントコーヒー(ネスレ日本株式会社製;商品名ネスカフェゴールドブレンドレギュラーソリュブルコーヒー)2g及びアルブミン(和光純薬工業社製;品番011−21271)3g、塩化第二鉄3gを加え、撹拌溶解し、ステイン溶液を得た。
[Test Example 1]
The stain solution was prepared as follows.
Two bags of black tea tea bag (manufactured by Unilever Japan Ltd .; trade name Sir Thomas Lipton) were added to about 600 mL of boiling water and boiled for 10 minutes. After cooling to room temperature, 2 g of instant coffee (Nestle Japan Ltd .; trade name Nescafe Gold Blend regular soluble coffee) and 3 g of albumin (Wako Pure Chemical Industries, product number 011-21271) and 3 g of ferric chloride are added and stirred. Dissolve to obtain a stain solution.
表2に示す試験液をステイン付着抑制剤として準備した。以下のようにして、歯牙サンプルに対する試験液のステイン付着抑制の程度を評価した。
・ハイドロキシアパタイトペレット(HOYA Technosurgical社製;品番アパタイトペレットAPP-100)を30v/v%リン酸水溶液に10分間浸漬してエッチング処理を行い、水洗した。自然乾燥し、歯牙サンプルを得た。色差計(島津製作所社製;型番CLR-7100F)を用い、歯牙サンプルの色差を測定した。
・歯牙サンプルを、0.5w/w%アルブミン溶液に10分間浸漬、実施例、比較例及び参考例の試験液に1分浸漬、ステイン溶液に30分間浸漬、及び水に30秒浸漬をこの順番で行うステイン付着処理を15回繰り返した。
・自然乾燥後、歯牙サンプルの色差を測定した。
・ステイン付着処理前の色差とステイン付着後の色差とからΔEを算出し、以下の式に基
づいて、各試験液のステイン付着抑制率を求めた。
The test solutions shown in Table 2 were prepared as stain adhesion inhibitors. The degree of stain adhesion inhibition of the test solution to the tooth sample was evaluated as follows.
A hydroxyapatite pellet (manufactured by HOYA Technosurgical, product number apatite pellet APP-100) was subjected to an etching treatment by immersion in a 30 v / v% phosphoric acid aqueous solution for 10 minutes, and washed with water. It dried naturally and obtained the tooth sample. The color difference of the tooth sample was measured using a color difference meter (manufactured by Shimadzu Corporation; model number CLR-7100F).
Soak tooth samples in 0.5 w / w% albumin solution for 10 minutes, soak in the test solutions of Examples, Comparative Examples and Reference Examples for 1 minute, soak in stain solution for 30 minutes, and soak in water for 30 seconds in this order The stain adhesion process carried out in the above was repeated 15 times.
After natural drying, the color difference of the tooth sample was measured.
-ΔE was calculated from the color difference before stain adhesion treatment and the color difference after stain adhesion treatment, and the stain adhesion inhibition rate of each test solution was determined based on the following equation.
表2の結果から、比較例1に示すように、精製水のみではステイン付着抑制効果は認められなかった。また、参考例に示すように、2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体にはステイン付着抑制効果が一応認められた。これに対し、実施例1〜実施例6に示すように、植物油にもそれぞれ単独でステイン付着抑制効果が認められた。中でも、ヨウ素価が150以下である植物油(実施例2〜実施例6)では、2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体をはるかに上回る好ましいステイン付着抑制効果が認められ、ヨウ素価が130以下である植物油(実施例3〜実施例6)では、より好ましいステイン付着抑制効果が認められた。特に、ヨウ素価が110以下である植物油(実施例4〜実施例6)では、さらに好ましいステイン付着抑制効果が認められた。 From the results of Table 2, as shown in Comparative Example 1, no stain adhesion inhibitory effect was observed only with purified water. Further, as shown in the reference example, the stain adhesion inhibitory effect was temporarily recognized in the 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer. On the other hand, as shown in Examples 1 to 6, each of the vegetable oils alone was found to have a stain adhesion suppressing effect. Among them, in a vegetable oil having an iodine value of 150 or less (Examples 2 to 6), a preferable stain adhesion inhibitory effect far exceeding that of 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer is recognized, and the iodine value is In the vegetable oil (Example 3-Example 6) which is 130 or less, more preferable stain adhesion inhibitory effect was recognized. In particular, in the vegetable oil (Example 4-Example 6) whose iodine value is 110 or less, the more preferable stain adhesion inhibitory effect was recognized.
[試験例2]
表3に示す試験液を口腔用組成物として調製した。表3の試験液は、水中油滴型のエマルジョンであった。得られた試験液について、試験例1と同様にステイン付着抑制の程度を評価した。
[Test Example 2]
The test solution shown in Table 3 was prepared as an oral composition. The test liquid of Table 3 was an oil-in-water emulsion. The degree of stain adhesion inhibition was evaluated for the obtained test solution as in Test Example 1.
表3の結果から、比較例2に示すように、植物油を含有しない場合、ステイン付着抑制効果が殆ど認められなかったが、実施例7〜9に示すように、植物油からなるステイン付着抑制剤は、エマルジョン中でステイン付着抑制効果が示された。また、ヨウ素価が65未満である植物性スクワラン及びヤシ油((B)成分)は単独でのステイン付着抑制能は、ヨウ素価が65以上である植物油((A)成分)には劣るものの、実施例8及び9に示すように、(A)成分に組み合わされることで、ステイン付着抑制能を向上させることができた。 From the results of Table 3, as shown in Comparative Example 2, when the vegetable oil was not contained, the stain adhesion inhibitory effect was hardly recognized, but as shown in Examples 7 to 9, the stain adhesion inhibitor comprising vegetable oil was In the emulsion, the stain adhesion inhibitory effect was shown. In addition, vegetable squalane and coconut oil (component (B)) having an iodine value of less than 65 are inferior in stain adhesion suppressing ability alone to vegetable oil (component (A)) having an iodine value of 65 or more, As shown in Examples 8 and 9, the stain adhesion suppressing ability could be improved by combining with the component (A).
また、表2及び表3の結果から、実施例2〜9に示されるように、植物油のヨウ素価と含有量(重量%)との積の総和が18050以下となる組成のステイン付着抑制剤は、2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体を上回る好ましいステイン付着抑制効果が認められ;実施例3〜9に示されるように、植物油のヨウ素価と含有量(重量%)との積の総和が200〜12600となる組成のステイン付着抑制剤は、より好ましいステイン付着抑制効果が認められ;実施例4〜9に示されるように、植物油のヨウ素価と含有量(重量%)との積の総和が200〜9000となる組成のステイン付着抑制剤は、さらに好ましいステイン付着抑制効果が認められ;実施例5,6,8,9に示されるように、植物油のヨウ素価と含有量(重量%)との積の総和が200〜8500となる組成のステイン付着抑制剤は、特に好ましいステイン付着抑制効果が認められた。 Moreover, the stain adhesion inhibitor of the composition from which the sum total of the product of the iodine value of a vegetable oil and content (weight%) becomes 18050 or less as Example 2-9 shows from the result of Table 2 and Table 3 And a preferable stain adhesion inhibitory effect over 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer is observed; product of iodine value of vegetable oil and content (% by weight) as shown in Examples 3 to 9 The stain adhesion inhibitor having a composition in which the sum total of 200 to 12600 has a more preferable stain adhesion inhibitory effect is recognized; as shown in Examples 4 to 9, the iodine value and the content (% by weight) of the vegetable oil The stain adhesion inhibitor having a composition having a sum of products of 200 to 9,000 has a further preferable stain adhesion inhibitory effect; Content and iodine value of the oil (wt%) and the product of the sum stain adhesion inhibitor composition comprising a 200-8500 is particularly preferred stain deposition inhibiting effect was observed.
[処方例]
表4〜6に示す練歯磨、表7に示すマウスリンス及び表8に示すマウススプレーを調製した。表4〜8においてはいずれも、各成分の含有量を示す数値の単位は、重量部である。当該練歯磨、マウスリンス及びマウススプレーは、植物油からなるステイン付着抑制剤が含まれており、いずれも、ステイン付着抑制作用に優れるものであった。
[Example of prescription]
The toothpaste shown in Tables 4-6, the mouthrinse shown in Table 7 and the mouse spray shown in Table 8 were prepared. In each of Tables 4 to 8, the unit of the numerical value indicating the content of each component is part by weight. The toothpaste, the mouthrinse and the mouse spray contained a stain adhesion inhibitor comprising vegetable oil, and all of them were excellent in stain adhesion inhibitory action.
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US20080031831A1 (en) * | 2005-10-21 | 2008-02-07 | Technology & Marketing Consulting | Oral anti-calculus compositions and methods of use thereof |
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