JP2019038790A - Hair cosmetic - Google Patents
Hair cosmetic Download PDFInfo
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- JP2019038790A JP2019038790A JP2017163688A JP2017163688A JP2019038790A JP 2019038790 A JP2019038790 A JP 2019038790A JP 2017163688 A JP2017163688 A JP 2017163688A JP 2017163688 A JP2017163688 A JP 2017163688A JP 2019038790 A JP2019038790 A JP 2019038790A
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- extract
- hair
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Abstract
Description
本発明は、天然物由来の生体安全性にすぐれ、毛髪の色調変化の予防・改善効果及び養毛効果を発揮する新規有効成分を含む毛髪化粧料に関するものである。 The present invention relates to a hair cosmetic comprising a novel active ingredient that is excellent in biological safety derived from natural products, exhibits a preventive / improving effect on hair color change and a hair nourishing effect.
近年、ストレス、食生活の変化、加齢、紫外線等の様々な理由により、男性、女性を問わず毛髪の老化を訴える人が増加している。毛髪の老化としては、例えば、薄毛、抜け毛、ハリ・ツヤ・コシの低下、切れ毛、細化、色調変化が挙げられる。 In recent years, an increasing number of people complain of aging of hair regardless of men or women due to various reasons such as stress, changes in diet, aging, and ultraviolet rays. Examples of aging of hair include thinning hair, loss of hair, reduction in elasticity, gloss, and stiffness, cut hair, thinning, and color change.
上記毛髪の老化のうち、薄毛や抜け毛に関しては、様々な研究が行われ、アデノシンやミノキシジル等の有効成分を配合した育毛剤や、また、天然物である生薬(ショウキョウ、センブリ等)成分を配合した育毛剤が提案されている。一方、上記毛髪の老化の中でも、毛髪の色調変化(毛髪の灰色化、白化等)は様々な要因が関与していると考えられており、そのメカニズムが十分に解明されていない。このため、従来、毛髪の色調変化を予防・改善する有効成分が提案されているものの、まだ十分に効果を発揮するものがないのが現状である。 Among the aging of hair, various studies have been conducted on thinning hair and hair loss, and hair restorers that contain active ingredients such as adenosine and minoxidil, as well as natural herbal medicines (such as shrimp and assembly) ingredients. Blended hair restorers have been proposed. On the other hand, among the aging of the hair, it is considered that various changes are involved in the color change of the hair (graying, whitening, etc.), and the mechanism has not been fully elucidated. For this reason, although the active ingredient which prevents and improves the color tone change of hair is proposed conventionally, there is no thing which still exhibits a sufficient effect yet.
以上の従来技術の課題を鋭意検討した結果、本発明者らは、葛根の抽出物;紅藻、緑藻又は褐藻の抽出物とゲンチアナ抽出物の混合物;カミツレの抽出物;シャクヤク、モモ及びシソの抽出物の混合物が、毛髪のメラニン合成、メラノソーム形成、及びメラノソーム輸送の遺伝子に関する遺伝子の発現を亢進することで、すぐれた毛髪の色調変化の予防・改善効果(色素異常・脱失による灰色化・白化の予防・改善、紫外線による退色の予防・改善、及び黒髪の光沢向上等)を奏することを新たに見出し、本発明を完成させるに至った。 As a result of intensive studies on the above-mentioned problems of the prior art, the present inventors have found that a kudzu root extract; a mixture of red algae, green algae or brown algae extract and gentian extract; chamomile extract; peonies, peaches and perillas The mixture of extracts enhances the expression of genes related to melanin synthesis, melanosome formation, and melanosome transport genes in hair, thereby preventing and improving excellent hair color change (graying / The inventors have newly found out that whitening can be prevented / improved, fading is prevented / improved by ultraviolet rays, and the gloss of black hair is improved, thereby completing the present invention.
従来、葛根の抽出物を毛髪化粧料に配合されることは特許文献1により知られていた。また、緑藻、褐藻又は紅藻の抽出物を含む育毛剤、脱毛抑制剤については特許文献2,3により既に知られている。また、ゲンチアナ抽出物を含む育毛料についても、特許文献4により知られている。従来、カミツレの抽出物を含む養毛剤については特許文献5により知られている。また、シャクヤク、モモ又はシソの抽出物を含む育毛料については、特許文献6,7により知られている。また、ウコギ科トチバニンジン属のニンジン抽出物を含む養毛料については、特許文献8により知られている。 Conventionally, it has been known from Patent Document 1 that a kudzu root extract is blended in a hair cosmetic. Further, hair growth agents and hair loss inhibitors containing extracts of green algae, brown algae or red algae are already known from Patent Documents 2 and 3. Further, a hair growth material containing a gentian extract is also known from Patent Document 4. Conventionally, a hair nourishing agent containing an extract of chamomile is known from Patent Document 5. Patent Documents 6 and 7 disclose a hair-growth material containing an extract of peony, peach or perilla. In addition, Patent Document 8 discloses a hair nourishing agent containing a carrot extract of the genus Tochibaninjin.
しかし、葛根の抽出物;緑藻又は褐藻の抽出物とゲンチアナ抽出物の混合物;カミツレ抽出物;シャクヤク、モモ及びシソの抽出物の混合物;ウコギ科トチバニンジン属のニンジン抽出物が毛髪の色調変化の予防、改善効果を有することについては知られていなかった。 However, the extract of Kakkon; a mixture of green or brown algae extract and gentian extract; chamomile extract; a mixture of peonies, peaches and perilla extracts; It was not known about having an improvement effect.
本発明は、以下の(A)〜(E)のうちのいずれか1以上の成分を含む毛髪の色調変化の予防・改善剤である。
(A)葛根の抽出物;
(B)紅藻、緑藻又は褐藻の抽出物及びゲンチアナの抽出物の混合物;
(C)カミツレの抽出物;
(D)シャクヤク、モモ及びシソの抽出物の混合物;
(E)ウコギ科(Araliaceae)トチバニンジン属(Panax)のニンジンの抽出物
The present invention is a preventive / improving agent for color change of hair, comprising any one or more of the following (A) to (E).
(A) Kudzu root extract;
(B) a mixture of red algae, green algae or brown algae extracts and gentian extracts;
(C) chamomile extract;
(D) a mixture of peonies, peaches and perilla extracts;
(E) Carrot extract of Araliaceae genus Panax
本発明によれば、葛根の抽出物;紅藻、緑藻又は褐藻の抽出物とゲンチアナ抽出物の混合物;カミツレの抽出物;シャクヤク、モモ及びシソの抽出物の混合物;及びウコギ科トチバニンジン属のニンジン抽出物のいずれか1以上を含む毛髪の色調変化の予防、改善剤(色素異常・脱失による灰色化・白化の予防・改善、紫外線による退色の予防・改善、及び黒髪の光沢向上等)を提供することができる。 According to the invention, an extract of kudzu root; a mixture of red algae, green algae or brown algae extract and gentian extract; chamomile extract; a mixture of peonies, peaches and perilla extracts; Prevention of color change of hair containing any one or more of the extract, improving agent (prevention / improvement of graying / whitening due to pigment abnormalities / loss, prevention / improvement of fading due to ultraviolet rays, and improvement of gloss of black hair, etc.) Can be provided.
以下、本発明の好ましい実施の形態について詳細に説明する。
本発明において、「クズ」とは、マメ科(Fabaceae)クズ属(Pueraria)の植物である。使用部位として、クズの根(カッコン)が好ましい。
Hereinafter, preferred embodiments of the present invention will be described in detail.
In the present invention, “kudu” is a plant of the genus Fabaceae (Pueraria). The use site is preferably a waste root.
本発明において、緑藻類としては、例えば、アオサ属(Ulva)の緑藻(アオサ、ヒトエグサ、アオノリ等)、クロレラ属(chlorella)の緑藻、クラミドモナス属(Chlamydomonas)の緑藻が挙げられる。 In the present invention, examples of the green algae include green algae (Ulva) (Aosa, human egusa, aonori, etc.), green algae of Chlorella, and green algae of Chlamydomonas.
また、本発明において、褐藻類としては、例えば、コンブ属(Laminaria)、ワカメ属(Undaria)、オオウキモ属(Macrocystis)、モズク属(Nemacystus)、又はホンダワラ属(Sargassum)の褐藻が挙げられる。その中でも、コンブ属の褐藻類としては、例えば、ガゴメコンブ、マコンブ、リシリコンブ、ホソメコンブ、ミツイシコンブ、ヒロメが挙げられる。また、ワカメ属の褐藻類としては、アオワカメ、ヒロエ等が挙げられる。 In the present invention, examples of the brown algae include brown algae belonging to the genus Laminaria, Undaria, Macrocystis, Nemacystus, or Sargassum. Among them, examples of the brown algae belonging to the genus Kombu include gagome kombu, macomb, resilib, hosome kombu, honey comb, and hirome. In addition, examples of brown algae belonging to the genus Wakame include Aowakame and Hiroe.
また、本発明において、紅藻類としては、例えば、アマノリ属(Porphyra)の紅藻(アサクサノリ等)、テングサ属(Gelidium)の紅藻(マクサ等)、カタメンキリンサイ属(Betaphycus)の紅藻(カタメンキリンサイ等)、フノリ属(Gloiopeltis)の紅藻(ハナフノリ、マフノリ、フクロフノリ等)、スギノリ属(Chondracanthus)の紅藻が挙げられる。 Further, in the present invention, examples of red algae include, for example, red algae of the genus Porphyra (such as Asakusanori), red algae of the genus Genus (such as maca), and red algae (catamen) of the genus Betaphycus. And the like, the red algae of the genus Funio (Gloiopeltis) (such as hanafunori, mafunori, fukurofunori) and the red algae of the genus Chondracanthus.
本発明において、ゲンチアナとは、リンドウ科リンドウ属のゲンチアナ(Gentiana lutea)である。使用部位としては、全草、花、茎、葉、根等を用いることができる。 In the present invention, gentian is Gentiana lutea belonging to the genus Gentianaceae. As the use site, whole grass, flowers, stems, leaves, roots and the like can be used.
また、本発明において、カミツレとは、キク科(Asteraceae)シカギク属(Matricaria)のカミツレ(Matricaria recutita)である。使用部位としては、全草、花、茎、葉、根等を用いることができる。 Further, in the present invention, the chamomile is a chamomile (Matricaria recutita) of the genus Masteria (Asteraceae). As the use site, whole grass, flowers, stems, leaves, roots and the like can be used.
本発明で用いるシャクヤクとは、ボタン科(Paeoniaceae)ボタン属(Paeonia)の植物であって、種は、特に限定されるものではなく、例えば、シャクヤク(Paeonia lactiflora)、ヤマシャクヤク(Paeonia japonica)、ベニバナヤマシャクヤク(Paeonia obovata)等が挙げられる。また、当該植物の全草、葉、花部、茎、種子、実、根等、いずれを用いても良いが、全草、根又は花の使用が好ましい。 The peony used in the present invention is a plant of the Paeoniaceae genus Paeonia, and the species is not particularly limited. For example, peony (Paeonia lactiflora), peony japonica, Examples thereof include Paeonia obovata. In addition, any of whole plant, leaves, flower parts, stems, seeds, fruits, roots, etc. of the plant may be used, but use of whole plants, roots or flowers is preferred.
本発明で用いるモモは、バラ科(Rosaceae)サクラ属(Prunus)の植物であって、種は、特に限定されるものではない。また、当該植物の全草、葉、花部、茎、種子、実、根等、いずれを用いても良いが、全草、種子又は果実(成熟、未成熟のいずれも使用可能)の使用が好ましい。 The peach used in the present invention is a plant belonging to the family Rosaceae (Prunus), and the species is not particularly limited. In addition, the whole plant, leaves, flower parts, stems, seeds, fruits, roots, etc. of the plant may be used, but the use of whole plants, seeds or fruits (both mature and immature can be used) preferable.
本発明で用いるシソとは、シソ科(Lamiaceae)シソ属(Perilla)の植物種は、特に限定されるものではない。なお、シソとしては、一般的に、学名として、Perilla frutescens var. Crispa、又はPerilla frutescens var. Brittonで表記されるものを含み、例えば、アオジソ、チリメンジソ、アカジソ、マダラジソ、カタメンジソ、チリメンアオジソ又はこれらの変種もしくは亜種、或いは交配種が挙げられるが、本発明はこれに限るものではない。また、当該植物の全草、葉、花部、茎、種子、実、根等、いずれを用いても良いが、全草又は葉の使用が好ましい。 The perilla used in the present invention is not particularly limited to the plant species of the Lamiaceae perilla genus (Perilla). In addition, as perilla, generally, the scientific name includes those expressed by Perilla frutescens var. Crispa or Perilla frutescens var. Britton.For example, Aojiso, Chilemiso, Akajiso, Madarajiso, Catamendizo, Chilemanaojiso or these Variants or subspecies, or hybrids may be mentioned, but the present invention is not limited thereto. Any of the whole plant, leaves, flower parts, stems, seeds, fruits, roots, etc. of the plant may be used, but the use of whole plants or leaves is preferred.
本発明で用いるウコギ科トチバニンジン属のニンジンとしては、オタネニンジン(Panax ginseng C.A. Meyer)、トチバニンジン(Panax japonicus)、サンシチニンジン(三七人参、Panax pseudoginseng)等が挙げられる。また、ニンジンの抽出物部位には特に限定はなく、全草、葉、花、雄しべ、雌しべ、茎、根、種子(子実)、果実など適宜の部位を用いることができるが、サポニンの含有量から、根、果実の使用が好ましい。また、トチバニンジン属植物の根を加工して得られる紅参や白参も使用可能である。 Examples of the carrot belonging to the genus Tochibanin ginseng used in the present invention include Panax ginseng C.A. Meyer, Panax japonicus, Sancynin carrot (Ginseng, Panax pseudoginseng) and the like. The carrot extract site is not particularly limited, and suitable sites such as whole grass, leaves, flowers, stamens, pistils, stems, roots, seeds (grains) and fruits can be used. From the amount, the use of roots and fruits is preferred. Red ginseng and white ginseng obtained by processing the roots of plants belonging to the genus Tochibaninjin are also usable.
抽出物の調製は、抽出対象物である植物を、必要ならば予め水洗して異物を除いた後、これをそのままもしくは乾燥し、さらに必要ならば細切或いは粉砕した上、浸漬法、向流抽出法、水蒸気蒸留法等の常法に従って抽出溶媒と接触させることによって行うことができる。また、本発明において、超臨界抽出法を採用してもよい。 The extract is prepared by washing the plant to be extracted beforehand with water if necessary to remove foreign substances, and then leaving it as it is or drying, and further chopping or pulverizing it if necessary, followed by a dipping method or countercurrent flow. It can carry out by making it contact with an extraction solvent in accordance with conventional methods, such as an extraction method and a steam distillation method. In the present invention, a supercritical extraction method may be employed.
抽出物処理に使用する抽出溶媒としては、水;メタノール、エタノール、プロパノールなどの低級アルコール類;エチレングリコール、プロピレングリコール、1,3−ブチレングリコール、グリセリンなどの多価アルコール類;酢酸エチル、酢酸ブチル、プロピオン酸メチルなどのエステル類;アセトン、メチルエチルケトンなどのケトン類;エチルエーテル、イソプロピルエーテルなどのエーテル類;n−ヘキサン、トルエン、クロロホルムなどの炭化水素系溶媒などが挙げられ、それらは単独でもしくは二種以上混合して用いられる。 The extraction solvent used for the extract treatment includes water; lower alcohols such as methanol, ethanol and propanol; polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol and glycerin; ethyl acetate and butyl acetate. And esters such as methyl propionate; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; and hydrocarbon solvents such as n-hexane, toluene and chloroform. A mixture of two or more types is used.
抽出物の調製に当たって、抽出液のpHに特に制限はないが、一般にはpH3〜9の範囲とすることが好ましい。pHの調整は、前記した抽出溶媒中に、水酸化ナトリウム、炭酸ナトリウム、水酸化カリウムなどのアルカリ性調整剤や、クエン酸、塩酸、リン酸、硫酸などの酸性調整剤等を配合することによって行うことができる。 In preparing the extract, the pH of the extract is not particularly limited, but it is generally preferably in the range of pH 3-9. The pH is adjusted by blending an alkaline adjusting agent such as sodium hydroxide, sodium carbonate or potassium hydroxide, or an acidic adjusting agent such as citric acid, hydrochloric acid, phosphoric acid or sulfuric acid into the extraction solvent. be able to.
抽出温度、時間等の抽出条件は、用いる溶媒の種類やpH、或いは抽出素材の大きさ等によっても異なるが、例えばメタノール又はエタノール、或いは水と低級アルコール又は多価アルコールとの混合溶媒を抽出溶媒とする浸漬法の場合であれば、抽出温度は0〜80℃の範囲である。抽出時間は、4℃の冷温抽出の場合で1時間〜7日間の範囲とするのがよく、また、40℃付近の中温抽出では、1時間〜5日間の範囲とするのがよく、70〜80℃の高温抽出の場合は、1時間〜2日間の範囲とするのがよい。浸漬法の場合、浴比は重量比で、抽出素材に対して溶媒が一般に1〜200倍量、好ましくは1〜100倍量の範囲となるようにするのがよい。 Extraction conditions such as extraction temperature and time vary depending on the type and pH of the solvent used, the size of the extraction material, and the like. For example, methanol or ethanol, or a mixed solvent of water and lower alcohol or polyhydric alcohol is used as the extraction solvent. In the case of the immersion method, the extraction temperature is in the range of 0 to 80 ° C. In the case of cold extraction at 4 ° C., the extraction time is preferably in the range of 1 hour to 7 days, and in the middle temperature extraction around 40 ° C., it is preferably in the range of 1 hour to 5 days. In the case of high-temperature extraction at 80 ° C., the range is preferably 1 hour to 2 days. In the case of the dipping method, the bath ratio is a weight ratio, and the solvent is generally in the range of 1 to 200 times, preferably 1 to 100 times the amount of the extraction material.
以上のようにして調製される抽出物は、さらに、活性炭処理、イオン交換樹脂処理、合成吸着剤、シリカゲル、及び再結晶処理のいずれか1種又は2種以上を組み合わせて、特定の有効成分を高濃度に含む抽出物に調製することでもよい。活性炭としては、松等の木、竹、椰子殻、胡桃殻等の植物質のほか、石炭質、石油質等を原材料として、それらの原材料に水蒸気や二酸化炭素、空気等のガスを使う高温炭化法等の物理的な方法や塩化亜鉛等の化学薬品を使って処理した上で加熱し、多孔質にする化学的な方法による活性化処理を施して得られる活性炭等の何れを用いても良い。また、合成吸着剤としては、スチレン/ジビニルベンゼン共重合体、メタクリル酸エステル重合体等の非イオン性樹脂が挙げられる。 The extract prepared as described above further comprises a specific active ingredient by combining any one or more of activated carbon treatment, ion exchange resin treatment, synthetic adsorbent, silica gel, and recrystallization treatment. It is also possible to prepare an extract containing a high concentration. Activated carbon is not only plant materials such as pine trees, bamboo, coconut shells, walnut shells, etc., but also carbonaceous, petroleum, etc. as raw materials, and high temperature carbonization using gas such as water vapor, carbon dioxide, air etc. as those raw materials Any of activated carbon obtained by applying a physical method such as a chemical method or a chemical method such as zinc chloride and then heating and applying a chemical method to make it porous may be used. . Examples of the synthetic adsorbent include nonionic resins such as styrene / divinylbenzene copolymer and methacrylic acid ester polymer.
本発明に係る抽出物を毛髪化粧料(医薬部外品、外用医薬品も含む)に配合する場合、例えば、育毛・養毛料又は染毛料であれば、一般的には0.00001〜5.0重量%(固形分重量%、以下同じ)であり、好ましくは、0.001〜3.0重量%である。また、シャンプー等の洗髪用化粧料であれば、一般的には0.00001〜5.0重量%(固形分重量%、以下同じ)であり、好ましくは、0.0001〜1.0重量%である。また、リンスやコンディショナーであれば、一般的には0.00001〜5.0重量%(固形分重量%、以下同じ)であり、好ましくは、0.001〜1.0重量%である。 When the extract according to the present invention is blended in a hair cosmetic (including quasi-drugs and topical medicines), for example, if it is a hair restoration / hair restoration or hair dye, it is generally 0.00001 to 5.0. % By weight (solid content% by weight, hereinafter the same), preferably 0.001 to 3.0% by weight. Further, in the case of a hair-washing cosmetic such as shampoo, it is generally 0.00001 to 5.0% by weight (solid content% by weight, hereinafter the same), preferably 0.0001 to 1.0% by weight. It is. In the case of a rinse or a conditioner, it is generally 0.00001 to 5.0 wt% (solid content wt%, hereinafter the same), and preferably 0.001 to 1.0 wt%.
本発明に係る抽出物を毛髪化粧料に配合する際に、毛髪化粧料に用いられる他の活性成分(毛母細胞賦活剤、抗男性ホルモン剤、血行促進剤、皮脂分泌抑制剤、抗炎症剤、毛髪保護剤、毛周期の成長維持剤等)を組み合わせて配合するようにしてもよく、これによって、育毛・養毛効果、髪質の改善効果及び頭皮の炎症予防:改善効果等も期待することもできる。 When blending the extract according to the present invention into a hair cosmetic, other active ingredients used in the hair cosmetic (hair matrix cell activator, anti-androgen hormone agent, blood circulation promoter, sebum secretion inhibitor, anti-inflammatory agent , Hair protection agents, hair cycle growth maintenance agents, etc.) may also be combined, and this can also be expected to have hair growth / hair restoration effects, hair quality improvement effects, and scalp inflammation prevention: improvement effects, etc. You can also.
例えば、育毛・養毛効果を期待できる成分としては、ミノキシジル、シプロテロンアセテート、ペンタデカン酸グリセリド、6−アミノベンジルプリン(サイトプリン)、アデノシン、トランス−3,4'−ジメチル3−ヒドロキシフラバノン(t−フラバノン)、センブリエキス、ヒノキチオール、感光素、パントテン酸及びその誘導体、ビタミンE及びその誘導体、ニコチン酸誘導体(ニコチン酸アミド等)、塩化カルプロニウム、女性ホルモン類(エチニルエストラジオール、エストロン等)、サリチル酸、グリチルリチン酸ジカリウム、ヒノキチオール、塩化ベンザルコニウム、イソプロピルメチルフェノール、l−メントール、塩酸ピリドキシン(ビタミンB6)、チオキソロン、カンファー、レゾルシン、タマサキツヅラフジ根の抽出物、タマサキツヅラフジから得られるビス型アルカロイド、甘草エキス、センブリエキス、マイマイ花エキス、ローヤルゼリー発酵物、ハスの種子発酵物、イチョウエキス、パルダルコ樹皮エキス、オタネニンジンエキス、豆乳発酵液、黒大豆加水分解エキス、アッケシソウエキス、タケノコエキス、チョウジエキス、コラーゲン、アミノ酸類、及びビタミン類等が挙げられ、それらのいずれか1種又は2種以上を配合してもよい。 For example, the components that can be expected to have a hair growth and nourishing effect include minoxidil, cyproterone acetate, pentadecanoic acid glyceride, 6-aminobenzylpurine (cytopurine), adenosine, trans-3,4'-dimethyl 3-hydroxyflavanone (t -Flavanone), assembly extract, hinokitiol, photosensitizer, pantothenic acid and derivatives thereof, vitamin E and derivatives thereof, nicotinic acid derivatives (such as nicotinic acid amide), carpronium chloride, female hormones (such as ethinylestradiol and estrone), salicylic acid, Extraction of dipotassium glycyrrhizinate, hinokitiol, benzalkonium chloride, isopropylmethylphenol, l-menthol, pyridoxine hydrochloride (vitamin B6), thioxolone, camphor, resorcinol, Japanese cypress Bis-type alkaloids, licorice extract, assembly extract, maimai flower extract, fermented royal jelly, fermented lotus seed, ginkgo biloba extract, pardarco bark extract, ginseng extract, soymilk fermentation broth, black soybean hydrolyzate An extract, an extract of bamboo grass, a bamboo shoot extract, a clove extract, collagen, amino acids, vitamins and the like can be mentioned, and any one or more of them may be blended.
また、本発明に係る抽出物を含む毛髪化粧料には、上述の成分のほかに、通常、毛髪化粧料に用いられる成分、例えば油性成分、界面活性剤(合成系、天然物系)、保湿剤、増粘剤、防腐・殺菌剤、粉体成分、紫外線吸収剤、抗酸化剤、キレート剤、ph調整剤、色素、香料等を必要に応じて適宜配合することができる。また、本発明に係る有効成分の有効性、特長を損なわない限り、他の生理活性成分を組み合わせて配合することも何ら差し支えない。 In addition to the above-mentioned components, the hair cosmetic containing the extract according to the present invention usually contains components used for hair cosmetics, such as oily components, surfactants (synthetic systems, natural products), moisturizing agents. An agent, a thickener, an antiseptic / bactericidal agent, a powder component, an ultraviolet absorber, an antioxidant, a chelating agent, a ph adjuster, a pigment, a fragrance, and the like can be appropriately blended as necessary. Moreover, as long as the effectiveness and characteristics of the active ingredient according to the present invention are not impaired, it may be combined with other physiologically active ingredients.
ここで、油性成分としては、例えばオリーブ油、ホホバ油、ヒマシ油、大豆油、米油、米胚芽油、ヤシ油、パーム油、カカオ油、メドウフォーム油、シアーバター、ティーツリー油、アボガド油、マカデミアナッツ油、ニンジン油、オタネニンジン油、ベルガモット油、植物由来スクワラン等の植物由来の油脂類;ミンク油、タートル油等の動物由来の油脂類;ミツロウ、カルナウバロウ、ライスワックス、ラノリン等のロウ類;流動パラフィン、ワセリン、パラフィンワックス、スクワラン等の炭化水素類;ミリスチン酸、パルミチン酸、ステアリン酸、オレイン酸、イソステアリン酸、エイコセン酸等の脂肪酸類;ラウリルアルコール、セタノール、ステアリルアルコール等の高級アルコール類;ミリスチン酸イソプロピル、パルミチン酸イソプロピル、オレイン酸ブチル、2−エチルヘキシルグリセライド、高級脂肪酸オクチルドデシル(ステアリン酸オクチルドデシル等)等の合成エステル類及び合成トリグリセライド類等が挙げられる。 Here, as the oil component, for example, olive oil, jojoba oil, castor oil, soybean oil, rice oil, rice germ oil, palm oil, palm oil, cacao oil, meadow foam oil, sheer butter, tea tree oil, avocado oil, Macadamia nut oil, carrot oil, ginseng oil, bergamot oil, plant-derived oils such as squalane; animal-derived oils such as mink oil, turtle oil; waxes such as beeswax, carnauba wax, rice wax, lanolin; Hydrocarbons such as paraffin, petrolatum, paraffin wax, squalane; fatty acids such as myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, eicosenoic acid; higher alcohols such as lauryl alcohol, cetanol and stearyl alcohol; myristin Isopropyl acid, palmitic acid Isopropyl, butyl oleate, 2-ethylhexyl glycerides, synthetic esters and synthetic triglycerides such as higher fatty acid octyldodecyl (octyl stearate dodecyl and the like), and the like.
界面活性剤としては、例えばポリオキシエチレンアルキルエーテル、ポリオキシエチレン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビトール脂肪酸エステル等の非イオン界面活性剤;脂肪酸塩、アルキル硫酸塩、アルキルベンゼンスルホン酸塩、ポリオキシエチレンアルキルエーテル硫酸塩、ポリオキシエチレン脂肪アミン硫酸塩、ポリオキシエチレンアルキルフェニルエーテル硫酸塩、ポリオキシエチレンアルキルエーテル燐酸塩、α−スルホン化脂肪酸アルキルエステル塩、ポリオキシエチレンアルキルフェニルエーテル燐酸塩等のアニオン界面活性剤;第四級アンモニウム塩、第一級〜第三級脂肪アミン塩、トリアルキルベンジルアンモニウム塩、アルキルピリジニウム塩、2−アルキル−1−アルキル−1−ヒドロキシエチルイミダゾリニウム塩、N,N−ジアルキルモルフォルニウム塩、ポリエチレンポリアミン脂肪酸アミド塩等のカチオン界面活性剤;N,N−ジメチル−N−アルキル−N−カルボキシメチルアンモニオベタイン、N,N,N−トリアルキル−N−アルキレンアンモニオカルボキシベタイン、N−アシルアミドプロピル−N′,N′−ジメチル−N′−β−ヒドロキシプロピルアンモニオスルホベタイン等の両性界面活性剤等を使用することができる。 Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene Nonionic surfactants such as oxyethylene sorbitol fatty acid esters; fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkyl phenyl ether sulfates, Anions such as polyoxyethylene alkyl ether phosphates, α-sulfonated fatty acid alkyl ester salts, polyoxyethylene alkyl phenyl ether phosphates Surfactant; quaternary ammonium salt, primary to tertiary fatty amine salt, trialkylbenzylammonium salt, alkylpyridinium salt, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salt, N, Cationic surfactants such as N-dialkylmorphonium salts and polyethylene polyamine fatty acid amide salts; N, N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N, N, N-trialkyl-N-alkylene Amphoteric surfactants such as ammoniocarboxybetaine and N-acylamidopropyl-N ′, N′-dimethyl-N′-β-hydroxypropylammoniosulfobetaine can be used.
乳化剤又は乳化助剤としては、酵素処理ステビア等のステビア誘導体、サポニン又はその誘導体、カゼイン又はその塩(ナトリウム等)、糖と蛋白質の複合体、ショ糖又はそのエステル、ラクトース、大豆由来の水溶性多糖、大豆由来蛋白質と多糖の複合体、ラノリン又はその誘導体、コレステロール、ステビア誘導体(ステビア酵素処理物等)、ケイ酸塩(アルミニウム、マグネシウム等)、炭酸塩(カルシウム、ナトリウム等)、サポニン及びその誘導体、レシチン及びその誘導体(水素添加レシチン等)、乳酸菌醗酵米、乳酸菌醗酵発芽米、乳酸菌醗酵穀類(麦類、豆類、雑穀等)等を配合することもできる。 Examples of emulsifiers or emulsifiers include stevia derivatives such as enzyme-treated stevia, saponins or derivatives thereof, casein or salts thereof (sodium, etc.), sugar-protein complexes, sucrose or esters thereof, lactose, soybean-derived water-soluble Polysaccharides, soy-derived protein and polysaccharide complex, lanolin or derivatives thereof, cholesterol, stevia derivatives (stevia enzyme-treated products, etc.), silicates (aluminum, magnesium, etc.), carbonates (calcium, sodium, etc.), saponins and their Derivatives, lecithin and derivatives thereof (hydrogenated lecithin, etc.), lactic acid bacteria fermented rice, lactic acid bacteria fermented rice, lactic acid bacteria fermented cereals (wheat, legumes, millet, etc.) and the like can also be blended.
保湿剤としては、例えばグリセリン、プロピレングリコール、ジプロピレングリコール、1,3−ブチレングリコール、ポリエチレングリコール、ソルビトール、キシリトール、ピロリドンカルボン酸ナトリウム等があり、さらにトレハロース等の糖類、ムコ多糖類(例えば、ヒアルロン酸及びその誘導体、コンドロイチン及びその誘導体、ヘパリン及びその誘導体等)、エラスチン及びその誘導体、コラーゲン加水分解物、NMF関連物質、乳酸、尿素、高級脂肪酸オクチルドデシル、海藻抽出物、シラン根(白及)抽出物、各種アミノ酸及びそれらの誘導体が挙げられる。 Examples of the humectant include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidone carboxylate, and sugars such as trehalose, mucopolysaccharides (for example, hyaluron). Acid and derivatives thereof, chondroitin and derivatives thereof, heparin and derivatives thereof, elastin and derivatives thereof, collagen hydrolyzate, NMF related substances, lactic acid, urea, higher fatty acid octyldodecyl, seaweed extract, silane root (white and white) Examples include extracts, various amino acids, and derivatives thereof.
増粘剤としては、例えばアルギン酸、寒天、カラギーナン、フコイダン;シラン根(白及)抽出物;ペクチン、ローカストビーンガム、アロエ多糖体、アルカリゲネス産生多糖体等の多糖類;キサンタンガム、トラガントガム、グアーガム等のガム類;カルボキシメチルセルロース、ヒドロキシエチルセルロース等のセルロース誘導体;ポリビニルアルコール、ポリビニルピロリドン、カルボキシビニルポリマー、アクリル酸・メタクリル酸共重合体等の合成高分子類;ヒアルロン酸及びその誘導体;ポリグルタミン酸及びその誘導体等が挙げられる。 Examples of thickeners include alginic acid, agar, carrageenan, fucoidan; silane root (white and white) extract; polysaccharides such as pectin, locust bean gum, aloe polysaccharide, and alkaline genus producing polysaccharide; xanthan gum, tragacanth gum, guar gum and the like Gums; Cellulose derivatives such as carboxymethylcellulose and hydroxyethylcellulose; Synthetic polymers such as polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer and acrylic acid / methacrylic acid copolymer; Hyaluronic acid and its derivatives; Polyglutamic acid and its derivatives Is mentioned.
防腐・殺菌剤としては、例えば尿素;パラオキシ安息香酸メチル、パラオキシ安息香酸エチル、パラオキシ安息香酸プロピル、パラオキシ安息香酸ブチル等のパラオキシ安息香酸エステル類;フェノキシエタノール、ジクロロフェン、ヘキサクロロフェン、塩酸クロルヘキシジン、塩化ベンザルコニウム、サリチル酸、エタノール、ウンデシレン酸、フェノール類、ジャマール(イミダゾデイニールウレア)、プロパンジオール、1,2−ペンタンジオール、各種精油類、樹皮乾留物、大根発酵液、サトウキビ等の植物由来のエタノール又は1,3−ブチレングリコール等がある。 Examples of the antiseptic / bactericidal agent include urea; paraoxybenzoates such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and butyl paraoxybenzoate; phenoxyethanol, dichlorophene, hexachlorophene, chlorhexidine hydrochloride, benzaza chloride Plant-derived ethanol such as ruconium, salicylic acid, ethanol, undecylenic acid, phenols, jamal (imidazodenyl urea), propanediol, 1,2-pentanediol, various essential oils, dry bark, radish fermented liquor, sugarcane Alternatively, there is 1,3-butylene glycol.
粉体成分としては、例えばセリサイト、酸化チタン、タルク、カオリン、ベントナイト、酸化亜鉛、炭酸マグネシウム、酸化マグネシウム、酸化ジルコニウム、硫酸バリウム、無水ケイ酸、雲母、ナイロンパウダー、ポリエチレンパウダー、シルクパウダー、セルロース系パウダー、穀類(米、麦、トウモロコシ、キビ等)のパウダー、豆類(大豆、小豆等)のパウダー等がある。 Examples of powder components include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, nylon powder, polyethylene powder, silk powder, and cellulose. System powder, cereal (rice, wheat, corn, millet, etc.) powder, legume (soybean, red bean, etc.) powder, and the like.
紫外線吸収剤としては、例えばパラアミノ安息香酸エチル、パラジメチルアミノ安息香酸エチルヘキシル、サリチル酸アミル及びその誘導体、パラメトキシ桂皮酸2−エチルヘキシル、桂皮酸オクチル、オキシベンゾン、2,4−ジヒドロキシベンゾフェノン、2−ヒドロキシ−4−メトキシベンゾフェノン−5−スルホン酸塩、4−ターシャリーブチル−4−メトキシベンゾイルメタン、2−(2−ヒドロキシ−5−メチルフェニル)ベンゾトリアゾール、ウロカニン酸、ウロカニン酸エチル、アロエ抽出物等がある。 Examples of the ultraviolet absorber include ethyl paraaminobenzoate, ethylhexyl paradimethylaminobenzoate, amyl salicylate and derivatives thereof, 2-ethylhexyl paramethoxycinnamate, octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, 2-hydroxy-4 -Methoxybenzophenone-5-sulfonate, 4-tertiarybutyl-4-methoxybenzoylmethane, 2- (2-hydroxy-5-methylphenyl) benzotriazole, urocanic acid, ethyl urocanate, aloe extract, etc. .
抗酸化剤としては、例えばブチルヒドロキシアニソール、ブチルヒドロキシトルエン、没食子酸プロピル、ビタミンE及びその誘導体(例えば、ビタミンEニコチネート、ビタミンEリノレート等)等がある。 Examples of the antioxidant include butylhydroxyanisole, butylhydroxytoluene, propyl gallate, vitamin E and its derivatives (for example, vitamin E nicotinate, vitamin E linoleate, etc.).
キレート剤としては、例えばエチレンジアミンヒドロキシエチル三酢酸三ナトリウム、エデト酸又はその塩類、グルコン酸、フィチン酸、ポリリン酸ナトリウム、メタリン酸ナトリウム、ヒドロキシエタンジホスホン酸四ナトリウムなどがある。 Examples of chelating agents include trisodium ethylenediaminehydroxyethyl triacetate, edetic acid or salts thereof, gluconic acid, phytic acid, sodium polyphosphate, sodium metaphosphate, tetrasodium hydroxyethanediphosphonate, and the like.
pH調整剤としては、例えばクエン酸又はその塩類、乳酸又はその塩類、グリコール酸、コハク酸、塩酸、モノエタノールアミン、ジエタノールアミン、トリエタノールアミン、水酸化ナトリウム、水酸化カリウムなどがある。 Examples of the pH adjuster include citric acid or a salt thereof, lactic acid or a salt thereof, glycolic acid, succinic acid, hydrochloric acid, monoethanolamine, diethanolamine, triethanolamine, sodium hydroxide, potassium hydroxide and the like.
生理活性成分としては、例えば、胎盤抽出液、ソウハクヒ抽出物、ユキノシタ抽出物、米糠抽出物又はその加水分解物、白芥子抽出物又はその加水分解物、白芥子の発酵物、ムラサキシキブ抽出物、ハス種子抽出物又はその加水分解物、党参抽出物又はその加水分解物、ハトムギ加水分解物、ハトムギ種子発酵物、酒粕抽出物又はそれに含まれるセラミド、酒粕発酵物、パンダヌス・アマリリフォリウス(Pandanus amaryllifolius Roxb.)抽出物、アルカンジェリシア・フラバ(Arcangelicia flava Merrilli)抽出物、イネの葉の抽出物又はその加水分解物、ナス(ベルガモット、長ナス、賀茂ナス、米ナス等)抽出物又はその加水分解物、アンズ果実の抽出物、カタメンキリンサイ等の海藻の抽出物、クラゲ水、米抽出物又はその加水分解物、米醗酵エキス、発芽米抽出物又はその加水分解物、発芽米発酵物、ダマスクバラの花の抽出物、リノール酸及びその誘導体もしくは抽出物(例えばリポソーム化リノール酸等)、動物又は魚由来のコラーゲン及びその誘導体、エラスチン及びその誘導体、グリチルレチン酸及びその誘導体、t−シクロアミノ酸誘導体、ビタミンA及びその誘導体、アラントイン、ジイソプロピルアミンジクロロアセテート、γ−アミノ−β−ヒドロキシ酪酸、ヘチマ抽出物、キウイ抽出物、ヒマワリ種子又は芽の抽出物、ジュアゼイロ(Zizyphus joazeiro)抽出物、萱草(デイリリー)抽出物又は発酵物、ハイビスカスの花抽出物又は発酵物、ハゴロモグサ抽出物、チェリモヤ抽出物、マンゴー抽出物、マンゴスチン抽出物、フノリ抽出物、烏龍茶抽出物、紅富貴抽出物、紫蘭抽出物、山椒果皮又は種皮の抽出物又は加水分解物、ベニバナ花抽出物、カサブランカ抽出物、甘藷抽出物又はその発酵物、グアバ葉抽出物、ドクダミ抽出物、晩白柚抽出物、アロエ抽出物、イチジク花抽出物、リンゴ抽出物等がある。 Examples of the physiologically active component include placenta extract, Sahaku extract, Yukinosita extract, rice bran extract or hydrolyzate thereof, white coconut extract or hydrolyzate thereof, fermented white coconut, murasakixikib extract, lotus Seed extract or hydrolyzate thereof, Participant extract or hydrolyzate thereof, pearl barley hydrolyzate, pearl barley seed fermented product, sake lees extract or ceramide contained therein, fermented sake lees, Pandanus amaryllifolius Roxb .) Extract, Arcangelicia flava Merrilli extract, rice leaf extract or hydrolyzate thereof, eggplant (bergamot, long eggplant, Kamo eggplant, rice eggplant etc.) extract or hydrolyzed thereof , Apricot fruit extract, seaweed extract such as catamen giraffe, jellyfish water, rice extract or hydrolyzate thereof, rice fermentation extract, Sprouting rice extract or hydrolyzate thereof, fermented sprouting rice, extract of damask rose flower, linoleic acid and its derivatives or extracts (eg liposomal linoleic acid), animal or fish-derived collagen and its derivatives, Elastin and its derivatives, glycyrrhetinic acid and its derivatives, t-cycloamino acid derivative, vitamin A and its derivatives, allantoin, diisopropylamine dichloroacetate, γ-amino-β-hydroxybutyric acid, loofah extract, kiwi extract, sunflower seed or Bud extract, Zizyphus joazeiro extract, Daisy extract or fermented product, Hibiscus flower extract or fermented product, Hagoromogusa extract, Cherimoya extract, Mango extract, Mangosteen extract, Funori extract , Oolong tea extract, Hongfu extract, purple orchid extract , Yam pericarp or seed coat extract or hydrolysate, safflower flower extract, Casablanca extract, sweet potato extract or fermented product thereof, guava leaf extract, dokudami extract, evening birch extract, aloe extract, fig There are flower extract, apple extract and so on.
次に、製造例、処方例及び試験例によって本発明をさらに具体的に説明するが、本発明はそれらに限定されるものではない。なお、以下において、部はすべて重量部を、また%はすべて重量%を意味する。 Next, the present invention will be described more specifically with reference to production examples, formulation examples, and test examples, but the present invention is not limited thereto. In the following, all parts are parts by weight, and all percentages are% by weight.
製造例1.クズの根の抽出物の調製(1)
クズの根の粉末1kgにエタノール10Lに加えて加温抽出した。次に、得られた抽出液を濾過、濃縮後、合成吸着剤のカラムに吸着させ、エタノールで溶出することにより、イソフラボンを高濃度に含む溶液を回収した。次に、濃縮液を乾燥して、褐色粉末45gを得た。この粉末40gに水とブチレングルコールの混合溶媒960gを加えて撹拌した後、濾過し、濃褐色透明の抽出物溶液910gを得た(固形分量3.44%)。
Production Example 1 Preparation of Kudzu root extract (1)
To 1 kg of waste root powder, 10 L of ethanol was added and extracted by heating. Next, the obtained extract was filtered, concentrated, adsorbed on a synthetic adsorbent column, and eluted with ethanol to collect a solution containing isoflavone at a high concentration. Next, the concentrated liquid was dried to obtain 45 g of a brown powder. To 40 g of this powder, 960 g of a mixed solvent of water and butylene glycol was added and stirred, followed by filtration to obtain 910 g of a dark brown transparent extract solution (solid content: 3.44%).
製造例2.クズの根の抽出物の調製(2)
製造例1にて用いた抽出溶媒(エタノール)に代えてメタノールを用いるほかは、製造例1と同様の操作により、褐色粉末43gを得た。この粉末40gに水とブチレングルコールの混合溶媒960gを加えて撹拌した後、濾過し、濃褐色透明の抽出物溶液913gを得た(固形分量3.20%)。
Production Example 2 Preparation of Kudzu root extract (2)
43 g of brown powder was obtained by the same operation as in Production Example 1, except that methanol was used instead of the extraction solvent (ethanol) used in Production Example 1. To 40 g of this powder, 960 g of a mixed solvent of water and butylene glycol was added and stirred, followed by filtration to obtain 913 g of a dark brown transparent extract solution (solid content 3.20%).
製造例3.緑藻抽出物及びゲンチアナの抽出物の調製(1)
乾燥したアオサ70gに精製水と1,3−ブチレングリコールの混合液(7:3)1000gを加え4℃で18時間抽出し、これを濾過して、アオサ抽出液920gを得た。このアオサ抽出液920gに、別途、ゲンチアナ根(茎を含んでいてもよい)の水抽出を乾燥して調製したゲンチアナ粉末13.8gを加え、4℃で18時間抽出した。これを濾過して、褐色透明のアオサ・ゲンチアナ混合抽出物(固形分濃度2.01%)903gを得た。
Production Example 3 Preparation of green algae extract and gentian extract (1)
To 70 g of dried Aosa, 1000 g of a mixture of purified water and 1,3-butylene glycol (7: 3) was added and extracted at 4 ° C. for 18 hours, and this was filtered to obtain 920 g of Aosa extract. Separately, 13.8 g of gentian powder prepared by drying a water extract of gentian root (which may contain a stem) was added to 920 g of this Aosa extract, followed by extraction at 4 ° C. for 18 hours. This was filtered to obtain 903 g of a brown and clear Aosa-gentian mixed extract (solid content concentration 2.01%).
製造例4.褐藻抽出物及びゲンチアナの抽出物の調製(2)
製造例3において、アオサに代えて、コンブを用いる他は、製造例3と同様の操作により、褐色透明のコンブ・ゲンチアナ混合抽出物(固形分濃度2.00%)865gを得た。
Production Example 4 Preparation of brown algae extract and gentian extract (2)
In Production Example 3, 865 g of a brown and brown Kombu / Gentiana mixed extract (solid content concentration: 2.00%) was obtained by the same operation as in Production Example 3 except that kombu was used in place of Aosa.
製造例5.紅藻抽出物及びゲンチアナの抽出物の調製(3)
製造例3において、アオサに代えて、カタメンキリンサイを用いる他は、製造例1と同様の操作により、褐色透明のカタメンキリンサイ・ゲンチアナ混合抽出物(固形分濃度1.95%)853gを得た。
Production Example 5 Preparation of red algae extract and gentian extract (3)
In Production Example 3, except for using Catamen giraffe instead of Aosa, 853 g of a brown and transparent Catamen giraffe / gentian mixed extract (solid content concentration 1.95%) was obtained by the same operation as Production Example 1.
製造例6.カミツレの抽出物の調製
乾燥したカミツレの花100gに精製水1000gを加え4℃で48時間抽出し、これを濾過して、褐色透明のカミツレ抽出液(固形分濃度1.01%)863gを得た。
Production Example 6 Preparation of chamomile extract To 100 g of dried chamomile flowers, 1000 g of purified water was added and extracted at 4 ° C. for 48 hours, and this was filtered to obtain 863 g of a brown transparent chamomile extract (solid concentration 1.01%). It was.
製造例7.シャクヤク、モモ及びシソの抽出物の混合物溶液
シャクヤクの根を刻んだ後乾燥し、乾燥物50gを精製水250gに浸漬した後、1,3−ブチレングリコールを250g添加した。添加後、4℃で抽出を行った。そして、抽出液をろ過し、褐色透明のシャクヤク抽出物溶液442gを得た(固形分濃度3.50%)。また、バラ科サクラ属のモモの種子(トウニン)を乾燥後粉砕し、粉砕物50gを精製水250gに浸漬した後、1,3−ブチレングリコールを250g添加した。添加後4℃で抽出を行った。そして、抽出液をろ過し、淡黄色透明のトウニン抽出物溶液493gを得た(固形分濃度1.76%)。また、シソ科シソ属のシソの葉を乾燥し、乾燥物25gを精製水250gに浸漬し、1,3-ブチレングリコールを250g添加した。添加後、4℃で抽出を行った。そして、抽出液をろ過し、褐色透明のシソ抽出物溶液448gを得た(固形分濃度1.05%)。以上の3種の植物抽出物を混合後、不溶物を濾過し、褐色透明の抽出物混合溶液1239gを得た(固形分濃度1.58%)。
Production Example 7 Mixture solution of peonies, peaches and perilla extracts The peony roots were chopped and dried, 50 g of the dried product was immersed in 250 g of purified water, and 250 g of 1,3-butylene glycol was added. After the addition, extraction was performed at 4 ° C. Then, the extract was filtered to obtain 442 g of a brown transparent peony extract solution (solid concentration 3.50%). Further, peach seeds (tonin) belonging to the family Rosaceae were dried and pulverized, 50 g of the pulverized product was immersed in 250 g of purified water, and 250 g of 1,3-butylene glycol was added. Extraction was performed at 4 ° C. after the addition. The extract was filtered to obtain 493 g of a pale yellow transparent tonin extract solution (solid content concentration 1.76%). Also, perilla leaves belonging to the genus Labiatae were dried, 25 g of the dried product was immersed in 250 g of purified water, and 250 g of 1,3-butylene glycol was added. After the addition, extraction was performed at 4 ° C. The extract was filtered to obtain 448 g of a brown transparent perilla extract solution (solid content concentration 1.05%). After mixing the above three kinds of plant extracts, insoluble matters were filtered to obtain 1239 g of a brown transparent extract mixed solution (solid content concentration 1.58%).
製造例8.ニンジン抽出物の調製(1)
オタネニンジン乾燥物100gを粉砕し、50%エタノール水溶液200mLを添加した後、一昼夜攪拌抽出した。抽出液を濾過後、残渣に50%エタノール水溶液200mLを添加し、一昼夜攪拌抽出した。抽出液を濾過後、一回目の濾液を混合し、20%エタノールとなるまで濃縮することにより褐色透明のニンジン抽出物溶液187g得た(固形分濃度7.30%)。
Production Example 8 Preparation of carrot extract (1)
100 g of dried ginseng was pulverized, 200 mL of 50% aqueous ethanol solution was added, and the mixture was extracted by stirring overnight. After filtration of the extract, 200 mL of 50% ethanol aqueous solution was added to the residue, and the mixture was extracted by stirring all day and night. After the extract was filtered, the first filtrate was mixed and concentrated to 20% ethanol to obtain 187 g of a brown transparent carrot extract solution (solid content concentration 7.30%).
製造例9.ニンジン抽出物の調製(2)
オタネニンジンに代えて、トチバニンジンの乾燥物100gを使用する他は、製造例8と同様の操作により、ニンジン抽出物溶液153g得た(固形分濃度6.80%)。
Production Example 9 Preparation of carrot extract (2)
153 g of carrot extract solution was obtained in the same manner as in Production Example 8 except that 100 g of dried tochiban carrot was used instead of ginseng (solid content concentration 6.80%).
製造例10.ニンジン抽出物の調製(3)
紅参の乾燥物100gを使用する他は、製造例8と同様の操作により、ニンジン抽出物溶液171g得た(固形分濃度6.54%)。
Production Example 10 Preparation of carrot extract (3)
171 g of carrot extract solution was obtained by the same operation as in Production Example 8 except that 100 g of dried red ginseng was used (solid content concentration 6.54%).
試験例1.遺伝子発現評価試験
正常ヒトメラノサイトを増殖添加剤含有DermaLife(登録商標)[クラボウ社製]にて9×104個/mLに調製し、φ1.26cm24穴ウェルプレートに1mLを播種して、5%CO2、飽和水蒸気下、37℃で培養した。24時間培養後、さらに、製造例1〜10の抽出物を溶液として所定の濃度で含んだ培養液を添加して培養した。すなわち、製造例1〜7の抽出物に関しては、培養液全量に対して溶液として終濃度が1.0%となるように調整し、製造例8〜10に関しては終濃度が0.5%となるように調整した。また、各製造例の抽出物の比較対照として、50%1,3−ブチレングリコール溶液(製造例1,7に比較対象)、30%1,3−ブチレングリコール溶液(製造例2〜6の比較対象)、及び20%エタノール溶液(製造例8〜10の比較対象)をそれぞれ比較対象となる製造例の抽出物と同様の濃度になるように調整したコントロール区を設定した。24時間培養後、それぞれの試験区の細胞をTrizol試薬(Invitrogen社製)1mLで回収した。回収した細胞に対してクロロホルム(和光純薬工業社製)200μL添加して撹拌混合し遠心分離機(TOMY社製/MX-160)で15,000rpm、4℃の条件下で15分間遠心分離した後、水層のみを400μL分取した。回収した水層にイソプロパノール(和光純薬工業社製)500μLを添加して撹拌混合し、15,000rpm、4℃の条件下で15分間遠心分離してtotal RNAの沈殿物を得た。totalRNAに75%エタノールを1mL添加して撹拌して洗浄し、15,000rpm、4℃条件下で15分間遠心分離して沈殿を回収した。回収したtotal RNAを所定のキット(PrimeScript RT reagent Kit with gDNA Eraser (Perfect Real Time)[タカラバイオ社製])を用いて逆転写反応し、cDNAを合成した。合成したcDNAをサンプルとして、Thermal Cycler Dice(登録商標)Real Time System Single(タカラバイオ社製)、及びSYBR(登録商標)Premix Ex TaqTM II(Perfect Real Time)[タカラバイオ社製]を用いて、各種遺伝子の発現と、内部標準物質β−ACTIN遺伝子の発現の検出を行った。ここで、β−ACTINは、ハウスキーピング遺伝子(多くの組織や細胞中に共通して一定量発現する遺伝子であって、常に発現され,細胞の維持,増殖に不可欠な遺伝子である)の一つであり、発現量が常に一定とされていることから、PCRの実験では内部標準として用いられるものである。試験結果は、β−ACTIN遺伝子の発現量を一定とした場合の、それぞれの試験区での各遺伝子の発現量を比較した。本試験系においては、コントロール区のそれぞれの遺伝子の発現量を100としたときの他の試験区でのその遺伝子の発現量の相対値を求めた。
Test Example 1 Gene Expression Evaluation Test Normal human melanocytes are prepared to 9 × 10 4 cells / mL with DermaLife (registered trademark) (manufactured by Kurabo Industries Inc.) containing growth additives, 1 mL is seeded in a φ1.26 cm 24-well plate, 5% The cells were cultured at 37 ° C. under CO 2 and saturated steam. After culturing for 24 hours, a culture solution containing the extract of Production Examples 1 to 10 at a predetermined concentration was added and cultured. That is, for the extracts of Production Examples 1 to 7, the final concentration as a solution is adjusted to 1.0% with respect to the total amount of the culture solution, and for Production Examples 8 to 10, the final concentration is adjusted to 0.5%. did. Moreover, as a comparative control of the extract of each production example, a 50% 1,3-butylene glycol solution (to be compared with Production Examples 1 and 7) and a 30% 1,3-butylene glycol solution (Comparison of Production Examples 2 to 6) The control group which adjusted so that it might become the density | concentration similar to the extract of the manufacture example used as a comparison object for 20% ethanol solution (comparative object of manufacture examples 8-10), respectively was set. After culturing for 24 hours, the cells in each test group were collected with 1 mL of Trizol reagent (Invitrogen). 200 μL of chloroform (manufactured by Wako Pure Chemical Industries, Ltd.) is added to the collected cells, stirred and mixed, and then centrifuged at 15,000 rpm, 4 ° C. for 15 minutes with a centrifuge (TOMY / MX-160) Only 400 μL of the aqueous layer was collected. To the recovered aqueous layer, 500 μL of isopropanol (manufactured by Wako Pure Chemical Industries, Ltd.) was added, stirred and mixed, and centrifuged at 15,000 rpm at 4 ° C. for 15 minutes to obtain a total RNA precipitate. 1 mL of 75% ethanol was added to totalRNA, stirred and washed, and centrifuged at 15,000 rpm under 4 ° C. for 15 minutes to collect a precipitate. The recovered total RNA was subjected to reverse transcription using a predetermined kit (PrimeScript RT reagent Kit with gDNA Eraser (Perfect Real Time) [manufactured by Takara Bio Inc.]) to synthesize cDNA. Using the synthesized cDNA as a sample, Thermal Cycler Dice (registered trademark) Real Time System Single (manufactured by Takara Bio Inc.), and SYBR (registered trademark) Premix Ex TaqTM II (Perfect Real Time) [manufactured by Takara Bio Inc.] The expression of various genes and the expression of the internal standard substance β-ACTIN gene were detected. Here, β-ACTIN is one of housekeeping genes (a gene that is commonly expressed in a certain amount in many tissues and cells and is always expressed and is essential for cell maintenance and proliferation). Since the expression level is always constant, it is used as an internal standard in PCR experiments. As a test result, the expression level of each gene in each test section was compared when the expression level of the β-ACTIN gene was constant. In this test system, the relative value of the expression level of each gene in other test plots when the expression level of each gene in the control plot was set to 100 was determined.
試験例1の結果を表1に示す。
[表1]
The results of Test Example 1 are shown in Table 1.
[Table 1]
表1に示すように、本発明の製造例1〜2に係る抽出物は、チロシナーゼ遺伝子「TYR(tyrosinase)」の発現を亢進することが確認された。チロシナーゼはメラニンの合成に不可欠な酵素であることから、本発明の製造例1〜2に係る抽出物は、TYRの発現を亢進することで、毛髪のメラニン合成を促進し、毛髪の色調変化の予防・改善効果(色素異常・脱失による灰色化・白化の予防・改善、紫外線による退色の予防・改善、及び黒髪の光沢向上等)を奏することが示唆される。 As shown in Table 1, it was confirmed that the extracts according to Production Examples 1 and 2 of the present invention enhance the expression of the tyrosinase gene “TYR (tyrosinase)”. Since tyrosinase is an indispensable enzyme for melanin synthesis, the extracts according to Production Examples 1 and 2 of the present invention promote the melanin synthesis of hair by enhancing the expression of TYR, and the change in the color tone of hair. This suggests that it has preventive / improving effects (preventing / improving graying / whitening due to pigment abnormalities / depletion, preventing / improving fading due to ultraviolet rays, and improving gloss of black hair, etc.).
また、表1に示すように、本発明の製造例1〜2に係る抽出物は、PMEL(premelanosome protein)遺伝子の発現を亢進することが確認された。ここで、PMELは、メラノソームの構造タンパク質であり、メラノソームの骨格となることが知られている。毛髪のメラニンは、PMELに沈着してメラノソームを形成することで周囲の細胞へ輸送されることから、本発明の製造例1〜2に係る抽出物は、PMELの発現を亢進することで、メラノソーム形成を促進し、毛髪の色調変化の予防・改善効果(色素異常・脱失による灰色化・白化の予防・改善、紫外線による退色の予防・改善、及び黒髪の光沢向上等)を奏することが示唆される。 Moreover, as shown in Table 1, it was confirmed that the extracts according to Production Examples 1 and 2 of the present invention enhance the expression of PMEL (premelanosome protein) gene. Here, PMEL is a structural protein of melanosomes and is known to be a melanosome skeleton. Since melanin in hair is transported to surrounding cells by depositing on PMEL to form melanosomes, the extracts according to Production Examples 1 and 2 of the present invention enhance the expression of PMEL, thereby melanosomes It is suggested that it promotes the formation of hair and has the effect of preventing and improving color change of hair (pigment abnormalities, prevention and improvement of graying and whitening due to loss, prevention and improvement of fading due to ultraviolet rays, and improvement of gloss of black hair, etc.) Is done.
また、表1に示すように、本発明の製造例3〜6の抽出物は、メラノサイト内のメラノソームの輸送に関与する低分子量のGタンパク質の1つであるRAB27Aの発現を亢進することが確認された。RAB27Aは、メラノサイトにおける周辺細胞へのメラノソームの輸送に関与することが知られている。従って、本発明の製造例3〜6の抽出物は、RAB27Aの発現を亢進することで、メラノソームの毛母細胞への輸送を促進して、毛髪の色調変化の予防・改善効果(色素異常・脱失による灰色化・白化の予防・改善、紫外線による退色の予防・改善、及び黒髪の光沢向上等)を奏することが示唆される。 In addition, as shown in Table 1, it was confirmed that the extracts of Production Examples 3 to 6 of the present invention enhance the expression of RAB27A, which is one of low molecular weight G proteins involved in the transport of melanosomes in melanocytes. It was done. RAB27A is known to be involved in melanosome transport to surrounding cells in melanocytes. Therefore, the extracts of Production Examples 3 to 6 of the present invention promote the transport of melanosomes to the hair matrix cells by enhancing the expression of RAB27A, thereby preventing or improving the color tone of the hair (dye abnormalities / This suggests that the prevention and improvement of graying / whitening due to loss, prevention / improvement of fading due to ultraviolet rays, and improvement of luster of black hair, etc.).
また、表1に示すように、本発明の製造例7〜10の抽出物は、MLPH(Melanophilin)の発現量を亢進することが確認された。MLPHは、肌や毛髪が白くなる3型グリセリ症候群という遺伝子疾患の原因遺伝子産物として同定されたタンパク質です。現在、上記RAB27Aに特異的に結合するエフェクターとして働くことが明らかとなっているものです。このMLPHとRAB27Aが結合し、モータータンパク質であるミオシンVAと複合体を形成することで、メラノソームはアクチン繊維上を細胞膜付近まで輸送されることから、MLPHを発現亢進することは、メラノソームの毛母細胞への輸送を促進することが示唆される。 Moreover, as shown in Table 1, it was confirmed that the extracts of Production Examples 7 to 10 of the present invention enhance the expression level of MLPH (Melanophilin). MLPH is a protein that has been identified as the causative gene product of the genetic disease of type 3 glycerin syndrome that causes whitening of the skin and hair. It is now clear that it works as an effector that specifically binds to RAB27A. MLPH and RAB27A combine with each other to form a complex with myosin VA, which is a motor protein, and melanosomes are transported over the actin fiber to the vicinity of the cell membrane. It is suggested to facilitate transport to cells.
さらに、本発明の製造例1又は2の抽出物と、本発明の製造例3〜6の抽出物のいずれか1以上の抽出物と、本発明の製造例7〜10の抽出物のいずれか1以上を併用することで、メラニン合成、メラノソームの形成及びメラノソームの輸送を促進することができ、それらの相乗効果に基づき、毛髪の色調変化の予防・改善効果(色素異常・脱失による灰色化・白化、及び紫外線による退色の予防・改善、黒髪の光沢向上等)を、より向上させることができる。 Furthermore, the extract of Production Example 1 or 2 of the present invention, the extract of any one or more of the extracts of Production Examples 3 to 6 of the present invention, and the extract of Production Examples 7 to 10 of the present invention By using one or more in combination, melanin synthesis, melanosome formation and melanosome transport can be promoted, and based on their synergistic effects, hair color change prevention / improvement effect (graying due to pigment abnormalities and loss) -Prevention and improvement of whitening and fading due to ultraviolet rays, improvement of gloss of black hair, etc.) can be further improved.
処方例1.ヘアケア用化粧料
[成分] 部
1,3−ブチレングリコール 10.0
エタノール 20.0
グリチルリチン酸ジカリウム 0.1
タマサキツヅラフジ抽出物 0.01
製造例1の抽出物 5.0
製造例8の抽出物 0.3
香料 適量
精製水 全量が100部となる量
Formulation Example 1 Hair care cosmetics [ingredients] part 1,3-butylene glycol 10.0
Ethanol 20.0
Dipotassium glycyrrhizinate 0.1
Japanese cypress rafuji extract 0.01
Extract of Production Example 1 5.0
Extract of Production Example 8 0.3
Perfume Appropriate amount Purified water Total amount to 100 parts
処方例2.ヘアケア用化粧料
処方例1の成分中、製造例1の抽出物5.0に代えて、製造例2の抽出物5.0を用いるほかは処方例1と同様にしてヘアケア用化粧料を得た。
Formulation Example 2 Hair care cosmetics In the ingredients of Formulation Example 1, in place of Extract 5.0 of Production Example 1, Extract 5.0 of Production Example 2 is used, and a cosmetic for hair care is obtained in the same manner as Formulation Example 1. It was.
処方例3.ヘアケア用化粧料
処方例1の成分中、製造例1の抽出物5.0に代えて、製造例3の抽出物5.0を用いるほかは処方例1と同様にしてヘアケア用化粧料を得た。
Formulation Example 3 Hair care cosmetics In the ingredients of Formulation Example 1, in place of Extract 5.0 of Production Example 1, Extract 5.0 of Production Example 3 is used, and a cosmetic for hair care is obtained in the same manner as Formulation Example 1. It was.
処方例4.ヘアケア用化粧料
処方例1の成分中、製造例1の抽出物5.0に代えて、製造例4の抽出物5.0を用いるほかは処方例1と同様にしてヘアケア用化粧料を得た。
Formulation Example 4 Hair care cosmetics A hair care cosmetic is obtained in the same manner as in Formulation Example 1 except that Extract 5.0 of Production Example 4 is used instead of Extract 5.0 of Production Example 1 in the ingredients of Formulation Example 1. It was.
処方例5.ヘアケア用化粧料
処方例1の成分中、製造例1の抽出物5.0に代えて、製造例5の抽出物5.0を用いるほかは処方例1と同様にしてヘアケア用化粧料を得た。
Formulation Example 5 Hair care cosmetics A hair care cosmetic is obtained in the same manner as in Formulation Example 1 except that, in the ingredients of Formulation Example 1, Extract 5.0 of Production Example 5 is used instead of Extract 5.0 of Production Example 1. It was.
処方例6.ヘアケア用化粧料
処方例1の成分中、製造例1の抽出物5.0に代えて、製造例6の抽出物5.0を用いるほかは処方例1と同様にしてヘアケア用化粧料を得た。
Formulation Example 6 Hair care cosmetics A hair care cosmetic is obtained in the same manner as in Formulation Example 1 except that, in the ingredients of Formulation Example 1, Extract 5.0 of Production Example 6 is used instead of Extract 5.0 of Production Example 1. It was.
処方例7.ヘアケア用化粧料
処方例1の成分中、製造例1の抽出物5.0に代えて、製造例7の抽出物5.0を用いるほかは処方例1と同様にしてヘアケア用化粧料を得た。
Formulation Example 7 Hair care cosmetics In the ingredients of Formulation Example 1, instead of Extract 5.0 of Production Example 1, Extract 5.0 of Production Example 7 is used, and a cosmetic for hair care is obtained in the same manner as Formulation Example 1. It was.
処方例8.ヘアケア用化粧料
処方例1の成分中、製造例8の抽出物0.3に代えて、センブリ抽出物0.3を用いるほかは処方例1と同様にしてヘアケア用化粧料を得た。
Formulation Example 8 Hair care cosmetics Hair care cosmetics were obtained in the same manner as in Formulation Example 1 except that, in the ingredients of Formulation Example 1, instead of Extract 0.3 in Production Example 8, assembly extract 0.3 was used.
処方例9.ヘアケア用化粧料
処方例1の成分中、製造例8の抽出物0.3に代えて、製造例9の抽出物0.3を用いるほかは処方例1と同様にしてヘアケア用化粧料を得た。
Formulation Example 9 Hair care cosmetics In the ingredients of Formulation Example 1, hair extract cosmetics are obtained in the same manner as Formulation Example 1 except that Extract 0.3 of Production Example 9 is used instead of Extract 0.3 of Production Example 8. It was.
処方例10.ヘアケア用化粧料
処方例1の成分中、製造例8の抽出物0.3に代えて、製造例10の抽出物0.3を用いるほかは処方例1と同様にしてヘアケア用化粧料を得た。
Formulation Example 10 Hair care cosmetics A hair care cosmetic is obtained in the same manner as in Formulation Example 1 except that, in the ingredients of Formulation Example 1, the extract 0.3 of Production Example 10 is used instead of the Extract 0.3 of Production Example 8. It was.
処方例11.ヘアケア用化粧料
処方例1の成分中、タマサキツヅラフジ抽出物0.01に代えて、センブリ抽出物0.3を用いるほかは処方例1と同様にしてヘアケア用化粧料を得た。
Formulation Example 11 Hair care cosmetics Hair care cosmetics were obtained in the same manner as in Formulation Example 1, except that in the ingredients of Formulation Example 1, assembly extract 0.3 was used instead of Tamatsuki Rafuji Extract 0.01.
処方例12.ヘアケア用化粧料
[成分] 部
1,3−ブチレングリコール 10.0
エタノール 20.0
グリチルリチン酸ジカリウム 0.1
タマサキツヅラフジ抽出物 0.01
製造例1の抽出物 3.0
製造例3の抽出物 3.0
製造例6の抽出物 3.0
製造例7の抽出物 3.0
製造例8の抽出物 0.3
香料 適量
精製水 全量が100部となる量
Formulation Example 12. Hair care cosmetics [ingredients] part 1,3-butylene glycol 10.0
Ethanol 20.0
Dipotassium glycyrrhizinate 0.1
Japanese cypress rafuji extract 0.01
Extract of Production Example 1 3.0
Extract of Production Example 3 3.0
Extract of Production Example 6 3.0
Extract of Production Example 7 3.0
Extract of Production Example 8 0.3
Perfume Appropriate amount Purified water Total amount to 100 parts
処方例13.ヘアケア用化粧料
[成分] 部
l−メントール 0.8
アデノシン 1.0
製造例2の抽出物 2.0
製造例4の抽出物 2.0
製造例6の抽出物 2.0
センブリ抽出物 0.3
1,3−ブチレングリコール 10.0
フェノキシエタノール 0.2
エタノール 20.0
精製水 全量が100部となる量
Formulation Example 13 Cosmetics for hair care [Ingredients] part l-menthol 0.8
Adenosine 1.0
Extract of Production Example 2 2.0
Extract of Production Example 4 2.0
Extract of Production Example 6 2.0
Assembly extract 0.3
1,3-butylene glycol 10.0
Phenoxyethanol 0.2
Ethanol 20.0
Amount of purified water totaling 100 parts
処方例14.ヘアケア用化粧料
処方例13の成分中、アデノシンに代えて、ミノキシジルを用いるほかは処方例13と同様にしてヘアケア用化粧料を得た。
Formulation Example 14. Hair care cosmetics Hair care cosmetics were obtained in the same manner as in Formulation Example 13 except that Minoxidil was used instead of adenosine in the ingredients of Formulation Example 13.
処方例15.ヘアケア用化粧料
処方例13の成分中、アデノシンに代えて6−ベンジルアミノプリンを用いるほかは処方例13と同様にしてヘアケア用化粧料を得た。
Formulation Example 15. Hair Care Cosmetic A hair care cosmetic was obtained in the same manner as in Formulation Example 13 except that 6-benzylaminopurine was used instead of adenosine in the components of Formulation Example 13.
処方例16.ヘアケア用化粧料
[成分] 部
グリチルリチン酸ジカリウム 0.1
l−メントール 0.1
製造例1の抽出物 1.0
製造例3の抽出物 1.0
大豆レシチン 0.2
1,3−ブチレングリコール 10.0
エタノール 20.0
タケノコ皮エキス 3.0
アッケシソウエキス 3.0
ゲンチアナエキス 3.0
アマモエキス 3.0
精製水 全量が100部となる量
Formulation Example 16. Hair care cosmetics [ingredients] part Dipotassium glycyrrhizinate 0.1
l-Menthol 0.1
Extract of Production Example 1 1.0
Extract of Production Example 3 1.0
Soy lecithin 0.2
1,3-butylene glycol 10.0
Ethanol 20.0
Bamboo shoot extract 3.0
Hamcho Extract 3.0
Gentian extract 3.0
Amamo extract 3.0
Amount of purified water totaling 100 parts
処方例17.ヘアークリーム
[成分] 部
流動パラフィン 15.0
ワセリン 15.0
サラシミツロウ 2.0
製造例1の抽出物 3.0
製造例6の抽出物 3.0
製造例7の抽出物 3.0
カルボキシビニルポリマー 0.1
キサンタンガム 0.1
グリセリン 5.0
1、3−ブチレングリコール 2.0
ポリオキシエチレン硬化ヒマシ油 3.0
キレート剤 0.1
防腐剤 0.1
香料 0.1
色素 0.01
精製水 全量が100部となる量
Formulation Example 17. Hair cream [ingredient] part liquid paraffin 15.0
Vaseline 15.0
Sara honey bee 2.0
Extract of Production Example 1 3.0
Extract of Production Example 6 3.0
Extract of Production Example 7 3.0
Carboxyvinyl polymer 0.1
Xanthan gum 0.1
Glycerin 5.0
1,3-butylene glycol 2.0
Polyoxyethylene hydrogenated castor oil 3.0
Chelating agent 0.1
Preservative 0.1
Fragrance 0.1
Dye 0.01
Amount of purified water totaling 100 parts
処方例18.ヘアシャンプー
[成分] 部
N−ヤシ油脂肪酸メチルタウリンナトリウム 10.0
ポリオキシエチレン(3)アルキルエーテル硫酸ナトリウム 20.0
ラウリルジメチルアミノ酢酸ベタイン 10.0
ヤシ油脂肪酸ジエタノールアミド 4.0
メチルパラベン 0.1
クエン酸 0.1
製造例1の抽出物 3.0
製造例5の抽出物 3.0
製造例10の抽出物 3.0
コラーゲン 5.0
アマモエキス 5.0
アッケシソウエキス 5.0
パウダルコ樹皮エキス 5.0
シソ葉エキス 5.0
1,3−ブチレングリコール 2.0
精製水 全量が100部となる量
Formulation Example 18. Hair shampoo [ingredient] part N-coconut oil fatty acid methyl taurine sodium 10.0
Polyoxyethylene (3) sodium alkyl ether sulfate 20.0
Lauryldimethylaminoacetic acid betaine 10.0
Palm oil fatty acid diethanolamide 4.0
Methylparaben 0.1
Citric acid 0.1
Extract of Production Example 1 3.0
Extract of Production Example 5 3.0
Extract of Production Example 10 3.0
Collagen 5.0
Amamo extract 5.0
Hamcho Extract 5.0
Paudalco Bark Extract 5.0
Perilla leaf extract 5.0
1,3-butylene glycol 2.0
Amount of purified water totaling 100 parts
処方例19.ヘアシャンプー
処方例18の成分中、製造例1の抽出物3.0に代えて製造例2の抽出物3.0を用いるほかは処方例18と同様にしてヘアシャンプーを得た。
Formulation Example 19. Hair Shampoo A hair shampoo was obtained in the same manner as in Formulation Example 18 except that the extract 3.0 of Production Example 2 was used instead of the Extract 3.0 of Production Example 1 among the components of Formulation Example 18.
実施例20.ヘアリンス
[成分] 部
ポリオキシエチレン(10)硬化ヒマシ油 1.0
塩化ジステアリルジメチルアンモニウム 1.5
塩化ステアリルトリメチルアンモニウム 2.0
2−エチルヘキサン酸グリセリル 1.0
セタノール 3.2
ステアリルアルコール 1.0
メチルパラベン 0.1
製造例1の抽出物 3.0
製造例3の抽出物 3.0
製造例6の抽出物 3.0
製造例8の抽出物 3.0
1,3−ブチレングリコール 5.0
精製水 全量が100部となる量
Example 20. Hair Rinse [Component] Part Polyoxyethylene (10) hydrogenated castor oil 1.0
Distearyldimethylammonium chloride 1.5
Stearyltrimethylammonium chloride 2.0
Glyceryl 2-ethylhexanoate 1.0
Cetanol 3.2
Stearyl alcohol 1.0
Methylparaben 0.1
Extract of Production Example 1 3.0
Extract of Production Example 3 3.0
Extract of Production Example 6 3.0
Extract of Production Example 8 3.0
1,3-butylene glycol 5.0
Amount of purified water totaling 100 parts
実施例21.ヘアリンス
処方例20の成分中、製造例1の抽出物3.0に代えて製造例2の抽出物3.0を用いるほかは処方例20と同様にしてヘアリンスを得た。
Example 21. Hair rinse A hair rinse was obtained in the same manner as in Formulation Example 20 except that the extract 3.0 in Production Example 2 was used instead of the extract 3.0 in Production Example 1 among the ingredients in Formulation Example 20.
処方例22.ヘアリンス
処方例20の成分中、製造例3の抽出物3.0に代えて製造例4の抽出物3.0を用いるほかは処方例20と同様にしてヘアリンスを得た。
Formulation Example 22. Hair rinse A hair rinse was obtained in the same manner as in Formulation Example 20 except that the extract 3.0 in Production Example 4 was used instead of the extract 3.0 in Production Example 3 among the ingredients in Formulation Example 20.
処方例23.ヘアリンス
処方例20の成分中、製造例3の抽出物3.0に代えて製造例5の抽出物3.0を用いるほかは処方例20と同様にしてヘアリンスを得た。
Formulation Example 23. Hair rinse A hair rinse was obtained in the same manner as in Formulation Example 20 except that, in the components of Formulation Example 20, Extract 3.0 of Production Example 5 was used instead of Extract 3.0 of Production Example 3.
Claims (2)
(A)葛根の抽出物;
(B)紅藻、緑藻又は褐藻の抽出物とゲンチアナ抽出物の混合物;
(C)カミツレの抽出物;
(D)シャクヤク、モモ及びシソの抽出物の混合物;
(E)ウコギ科(Araliaceae)トチバニンジン属(Panax)のニンジンの抽出物 An agent for preventing or improving color change of hair, comprising one or more extracts of any of the following (A) to (E).
(A) Kudzu root extract;
(B) a mixture of red algae, green algae or brown algae extracts and gentian extracts;
(C) chamomile extract;
(D) a mixture of peonies, peaches and perilla extracts;
(E) Carrot extract of Araliaceae genus Panax
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JP2019210245A (en) * | 2018-06-05 | 2019-12-12 | 日本メナード化粧品株式会社 | CXCL12 expression promoter |
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