JP2019023215A - Maillard reaction inhibitor - Google Patents
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- JP2019023215A JP2019023215A JP2018191338A JP2018191338A JP2019023215A JP 2019023215 A JP2019023215 A JP 2019023215A JP 2018191338 A JP2018191338 A JP 2018191338A JP 2018191338 A JP2018191338 A JP 2018191338A JP 2019023215 A JP2019023215 A JP 2019023215A
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Abstract
Description
本発明は、植物エキスを有効成分として含有する新規なメイラード反応阻害剤に関する。 The present invention relates to a novel Maillard reaction inhibitor containing a plant extract as an active ingredient.
メイラード反応は、還元糖のカルボニル基と蛋白質又はアミノ酸のアミノ基が非酵素的に縮合する反応で、シッフ塩基を経由して、アマドリ転移産物を生成する前期反応と、その後、アマドリ転移産物が分解され、さらに脱水、酸化、縮合、転移等の過程を経て、終末糖化産物群（ＡＧＥ）へと変化する後期反応とに分けられる。食品の加工、貯蔵の際に起こる褐変反応として食品科学の分野では古くからよく知られる現象である。 The Maillard reaction is a reaction in which the carbonyl group of the reducing sugar and the amino group of the protein or amino acid are condensed non-enzymatically. The pre-reaction generates an Amadori transfer product via a Schiff base, and then the Amadori transfer product is decomposed. Furthermore, it is divided into a late reaction that changes to a terminal glycation end product group (AGE) through processes such as dehydration, oxidation, condensation, and transfer. It is a phenomenon that has long been well known in the field of food science as a browning reaction that occurs during the processing and storage of food.
この反応は生体内でも起こっており、ＡＧＥが加齢に依存して種々の生体組織に蓄積すること、また、糖尿病合併症、アルツハイマーや動脈硬化などの加齢関連疾患で、ＡＧＥの蓄積が有意に増加していることが報告されている。さらに、メイラード反応は、加齢に伴って生じる白内障や軟骨の弾力低下、皮膚の老化の原因となり、特に常時高血糖状態である糖尿病患者においてその進行が早いことが報告されている。 This reaction also occurs in vivo, and AGE accumulates in various biological tissues depending on aging, and AGE accumulation is significant in aging-related diseases such as diabetic complications, Alzheimer's and arteriosclerosis. Has been reported to increase. Furthermore, it has been reported that the Maillard reaction causes cataract, cartilage elasticity, and skin aging that occur with aging, and progresses rapidly in diabetic patients who are constantly hyperglycemic.
このため、メイラード反応を阻害する物質は、生体内の様々な加齢関連疾患の抑制や糖尿病合併症を抑制し得ると考えられ、そのような物質を求めて種々の研究がされている。 For this reason, it is considered that a substance that inhibits the Maillard reaction can suppress various aging-related diseases and diabetic complications in the living body, and various studies have been conducted for such substances.
例えば、アミノグアニジンは強力なメイラード反応阻害剤として知られている（例えば、特許文献１参照）。一方でこの化合物は強い副作用を有することが知られている。また、メイラード反応阻害作用を有する植物素材がいくつか知られているが、十分満足のいく効果は得られていない（例えば、特許文献２および特許文献３参照）。 For example, aminoguanidine is known as a potent Maillard reaction inhibitor (see, for example, Patent Document 1). On the other hand, this compound is known to have strong side effects. Moreover, although some plant materials which have the Maillard reaction inhibitory effect are known, the effect which is fully satisfactory is not acquired (for example, refer patent document 2 and patent document 3).
平均寿命の延びや少子高齢化の進行に伴い、健康を維持しつつ長生きするために、抗加齢いわゆるアンチエイジングへの関心が高まっている中、優れたアンチエイジング効果を有し、かつ安全性の高い機能性食品や化粧品素材等の開発が切望されている。 As life expectancy increases and the aging population declines, life expectancy increases while interest in anti-aging is increasing in order to maintain good health. Development of functional foods and cosmetic materials with high functionality is eagerly desired.
本発明は、植物エキスを有効成分として含有する新規なメイラード反応阻害剤を提供することを主な目的とする。また、本発明は、当該メイラード反応阻害剤を含有する経口剤、外用剤および飲食品を提供する。 The main object of the present invention is to provide a novel Maillard reaction inhibitor containing a plant extract as an active ingredient. Moreover, this invention provides the oral preparation, the external preparation, and food-drinks containing the said Maillard reaction inhibitor.
本発明者らは、上記課題を解決すべく鋭意検討した結果、特定の植物エキスが優れたメイラード反応阻害作用を有することを見出し、本発明を完成した。 As a result of intensive studies to solve the above problems, the present inventors have found that a specific plant extract has an excellent Maillard reaction inhibitory action, and have completed the present invention.
本発明として、例えば下記のものを挙げることができる。
（１）ピンポンノキ属（Ｓｔｅｒｃｕｌｉａ）に属する植物、チャンチンモドキ属（Ｃｈｏｅｒｏｓｐｏｎｄｉａｓ）に属する植物、マンゴー属（Ｍａｎｇｉｆｅｒａ）に属する植物、ウルシ属（Ｒｈｕｓ）に属する植物、フクギ属（Ｇａｒｃｉｎｉａ）に属する植物、クロモジ属（Ｌｉｎｄｅｒａ）に属する植物、イヌタデ属（Ｐｅｒｓｉｃａｒｉａ）に属する植物、ギシギシ属（Ｒｕｍｅｘ）に属する植物、ミズヒキ属（Ａｎｔｅｎｏｒｏｎ）に属する植物、アブラギリ属（Ａｌｅｕｒｉｔｅｓ）に属する植物、アカシア属（Ａｃａｃｉａ）に属する植物、ヒシ属（Ｔｒａｐａ）に属する植物、エウゲニア属（Ｅｕｇｅｎｉａ）に属する植物、ナツフジ属（Ｍｉｌｌｅｔｔｉａ）に属する植物、ミズキ属（Ｃｏｒｎｕｓ）に属する植物、ビンロウ属（Ａｒｅｃａ）に属する植物、ヤマモモ属（Ｍｙｒｉｃａ）に属する植物からなる植物群から選択される１種又は２種以上の植物のエキスを有効成分として含有するメイラード反応阻害剤（以下、「本発明阻害剤」という）。
（２）上記（１）のメイラード反応阻害剤を含有する経口剤（以下、「本発明経口剤」という）。
（３）上記（１）のメイラード反応阻害剤を含有する飲食品（以下、「本発明飲食品」という）。
（４）上記（１）のメイラード反応阻害剤を含有する外用剤（以下、「本発明外用剤」という）。
（５）上記（１）のメイラード反応阻害剤を含有する老化抑制用組成物（以下、「本発明組成物」という）。
（６）上記（１）のメイラード反応阻害剤を含有する、糖尿病合併症の予防又は治療用組成物。
Examples of the present invention include the following.
(1) Plants belonging to the genus Starculia, plants belonging to the genus Choerospondia, plants belonging to the genus Mangofera, plants belonging to the genus Rhus, plants belonging to the genus Garcinia, chromid Plants belonging to the genus (Lindera), plants belonging to the genus Persicaria, plants belonging to the genus Rumex, plants belonging to the genus Antenoron, plants belonging to the genus Aralites, and Acacia Plants belonging to the genus Trapa, plants belonging to the genus Eugenia, plants belonging to the genus Milletia, plants belonging to the genus Cornus, Maillard reaction inhibitor (hereinafter referred to as “this”) containing, as an active ingredient, an extract of one or more plants selected from the group consisting of plants belonging to the genus Areca and plants belonging to the genus Myrica Invention inhibitors ").
(2) An oral preparation containing the Maillard reaction inhibitor of the above (1) (hereinafter referred to as “the oral preparation of the present invention”).
(3) Food / beverage products containing the Maillard reaction inhibitor of said (1) (henceforth "the present food / beverage products").
(4) An external preparation containing the Maillard reaction inhibitor of the above (1) (hereinafter referred to as “the external preparation of the present invention”).
(5) A composition for suppressing aging containing the Maillard reaction inhibitor of (1) above (hereinafter referred to as “the composition of the present invention”).
(6) A composition for preventing or treating diabetic complications, comprising the Maillard reaction inhibitor of (1) above.
本発明阻害剤は、優れたメイラード反応阻害作用を有し、老化に伴って生じる現象、例えば、白内障、軟骨の弾力低下、皮膚の老化（皮膚の弾力低下、しわやたるみの原因となるコラーゲンの架橋形成、肌のくすみの原因となる色素沈着等）の抑制に有用である。また、本発明阻害剤は、食経験があり、副作用が少ない植物のエキスを有効成分として含有し、安全性が高いものである。 The inhibitor of the present invention has an excellent Maillard reaction inhibitory action and is a phenomenon that occurs with aging, such as cataracts, reduced cartilage elasticity, skin aging (decreased skin elasticity, wrinkles and sagging) It is useful for suppressing the formation of cross-links and pigmentation that causes dull skin. In addition, the inhibitor of the present invention contains a plant extract having a food experience and few side effects as an active ingredient, and has high safety.
また、本発明阻害剤は、メイラード反応が関与することが知られている糖尿病合併症の予防又は治療用組成物として用いることもできる。 The inhibitor of the present invention can also be used as a composition for preventing or treating diabetic complications known to involve Maillard reaction.
植物エキス
本発明に係る植物エキスは、ピンポンノキ属（Ｓｔｅｒｃｕｌｉａ）に属する植物、チャンチンモドキ属（Ｃｈｏｅｒｏｓｐｏｎｄｉａｓ）に属する植物、マンゴー属（Ｍａｎｇｉｆｅｒａ）に属する植物、ウルシ属（Ｒｈｕｓ）に属する植物、フクギ属（Ｇａｒｃｉｎｉａ）に属する植物、クロモジ属（Ｌｉｎｄｅｒａ）に属する植物、イヌタデ属（Ｐｅｒｓｉｃａｒｉａ）に属する植物、ギシギシ属（Ｒｕｍｅｘ）に属する植物、ミズヒキ属（Ａｎｔｅｎｏｒｏｎ）に属する植物、アブラギリ属（Ａｌｅｕｒｉｔｅｓ）に属する植物、アカシア属（Ａｃａｃｉａ）に属する植物、ヒシ属（Ｔｒａｐａ）に属する植物、エウゲニア属（Ｅｕｇｅｎｉａ）に属する植物、ナツフジ属（Ｍｉｌｌｅｔｔｉａ）に属する植物、ミズキ属（Ｃｏｒｎｕｓ）に属する植物、ビンロウ属（Ａｒｅｃａ）に属する植物、ヤマモモ属（Ｍｙｒｉｃａ）に属する植物からなる植物群から選択される植物からの抽出エキスである。
Plant Extract The plant extract according to the present invention comprises a plant belonging to the genus Starculia, a plant belonging to the genus Choerosponia, a plant belonging to the genus Mangofera, a plant belonging to the genus Rhus, Plants belonging to the genus Garcinia, plants belonging to the genus Lindera, plants belonging to the genus Persicaria, plants belonging to the genus Rumex, plants belonging to the genus Antenoron, plants belonging to the genus Aralites Plants belonging to the genus Acacia, plants belonging to the genus Trapa, plants belonging to the genus Eugenia, plants belonging to the genus Milletia, genus Mizuki Plants belonging to Cornus), an extract from a plant selected plants belonging to Areca genus (Areca), from a plant group consisting of plants belonging to the bayberry genus (Myrica).
本発明に係るピンポンノキ属（Ｓｔｅｒｃｕｌｉａ）に属する植物としては、特に限定されないが、例えば、ヤツデアオギリ（Ｓｔｅｒｃｕｌｉａ ｆｏｅｔｉｄａ Ｌ．）、ピンポンノキ（Ｓｔｅｒｃｕｌｉａ ｎｏｂｉｌｉｓ Ｓｍｉｔｈ）、ハンタイカイ（Ｓｔｅｒｃｕｌｉａ ｓｃａｐｈｉｇｅｒａ Ｗａｌｌ．）を挙げることができ、中でもヤツデアオギリ（Ｓｔｅｒｃｕｌｉａ ｆｏｅｔｉｄａ Ｌ．）が好ましい。 Examples of the plant belonging to the genus (Sterculia) according to the present invention are not particularly limited, and examples thereof include a starfish (Sterculia foetida L.), a ping pong tree (Sterculia nobilis Smith), and a hunter kai (Sterculia scaphier). Of these, Sterculia footida L. is preferable.
本発明に係るチャンチンモドキ属（Ｃｈｏｅｒｏｓｐｏｎｄｉａｓ）に属する植物としては、特に限定されないが、例えば、チャンチンモドキ（Ｃｈｏｅｒｏｓｐｏｎｄｉａｓ ａｘｉｌｌａｒｉｓ （Ｒｏｘｂ．） Ｂｕｒｔｔ ｅｔ Ｈｉｌｌ）が好ましい。 Although it does not specifically limit as a plant which belongs to the genus Chernospondias (Choreospondias) which concerns on this invention, For example, a Chanthospodias axillaris (Roxb.) Burtt Hill is preferable.
本発明に係るマンゴー属（Ｍａｎｇｉｆｅｒａ）に属する植物としては、特に限定されないが、例えば、マンゴー（Ｍａｎｇｉｆｅｒａ ｉｎｄｉｃａ Ｌ．）、ニオイマンゴー（Ｍａｎｇｉｆｅｒａ ｏｄｏｒａｔａ Ｇｒｉｆｆ．）、ビンジャイマンゴー（Ｍａｎｇｉｆｅｒａ ｃａｅｓｉａ Ｊａｃｋ．）、ウママンゴー（Ｍａｎｇｉｆｅｒａ ｆｏｅｔｉｄａ Ｌｏｕｒ．）を挙げることができ、中でもマンゴー（Ｍａｎｇｉｆｅｒａ ｉｎｄｉｃａ Ｌ．）が好ましい。 Although it does not specifically limit as a plant which belongs to the genus Mango (Mangifera) which concerns on this invention, For example, a mango (Mangifera indica L.), a mani (Mangifera odorata Griff.), A binjai mango (Mangifera caesia J.). Mango (Mangifera foota Lour.) Can be mentioned, among which mango (Mangifera indica L.) is preferable.
本発明に係るウルシ属（Ｒｈｕｓ）に属する植物としては、特に限定されないが、例えば、ヌルデ（Ｒｈｕｓ ｊａｖａｎｉｃａ Ｌ．）、ハゼノキ（Ｒｈｕｓ ｓｕｃｃｅｄａｎｅａ Ｌ．）、ナンヨウハゼノキ（Ｒｈｕｓｔａｉｔｅｎｓｉｓ Ｇｕｉｌｌ．）、ウルシ（Ｒｈｕｓ ｖｅｒｎｉｃｉｆｌｕａ Ｓｔｏｋｅｓ）、ヤマウルシ（Ｒｈｕｓ ｔｒｉｃｈｏｃａｒｐａ Ｍｉｑ．）を挙げることができ、中でもヌルデ（Ｒｈｕｓ ｊａｖａｎｉｃａ Ｌ．）が好ましい。 Although it does not specifically limit as a plant which belongs to Urushi genus (Rhus) which concerns on this invention, For example, Nurde (Rhus javanica L.), Hazenoki (Rhus succedanea L.), Eurasian redwood (Rhustaitensis Guill.), Urushi (Rhusver) Stokes) and Yamaurushi (Rhus trichocarpa Miq.) Can be mentioned, among which Nurde (Rhus javanica L.) is preferable.
本発明に係るフクギ属（Ｇａｒｃｉｎｉａ）に属する植物としては、特に限定されないが、例えば、マンゴスチン（Ｇａｒｃｉｎｉａ ｍａｎｇｏｓｔａｎａ Ｌ．）、ゴラカ（Ｇａｒｃｉｎｉａ ｃａｍｂｏｇｉａ Ｄｅｓｒ．）、ムムンジン（Ｇａｒｃｉｎｉａ ｄｉｏｉｃａ Ｂｌｕｍｅ）、グルグル（Ｇａｒｃｉｎｉａ ａｔｒｏｖｉｒｉｄｉｓ Ｇｒｉｆｆ． ｅｘ Ｔ． Ａｎｄｅｒｓｏｎ）、オオバノマンゴスチン（Ｇａｒｃｉｎｉａ ｄｕｌｃｉｓ （Ｒｏｘｂ．） Ｋｕｒｚ）、インドマンゴスチン（Ｇａｒｃｉｎｉａ ｉｎｄｉｃａ Ｃｈｏｉｓｙ）、フクギ（Ｇａｒｃｉｎｉａ ｓｕｂｅｌｌｉｐｔｉｃａ Ｍｅｒｒ．）、タマゴノキ（Ｇａｒｃｉｎｉａ ｘａｎｔｈｏｃｈｙｍｕｓ Ｈｏｏｋ． ｆ． ｅｘ Ｔ． Ａｎｄｅｒｓ．）を挙げることができ、中でもマンゴスチン（Ｇａｒｃｉｎｉａ ｍａｎｇｏｓｔａｎａ Ｌ．）が好ましい。 The plant belonging to the genus Garcinia according to the present invention is not particularly limited. Ex T. Anderson, Garcinia dulcis (Roxb.) Kurz, Indian mangostin (Garcinia inf. Chi.), F. (Garcinia sub. To mention Can, inter alia mangosteen (Garcinia mangostana L.) is preferable.
本発明に係るクロモジ属（Ｌｉｎｄｅｒａ）に属する植物としては、特に限定されないが、例えば、クロモジ（Ｌｉｎｄｅｒａ ｕｍｂｅｌｌａｔａ Ｔｈｕｎｂ．）、アメリカクロモジ（Ｌｉｎｄｅｒａ ｂｅｎｚｏｉｎ （Ｌ．）Ｂｌｕｍｅ）、テンダイウヤク（Ｌｉｎｄｅｒａ ｓｔｒｙｃｈｎｉｆｏｌｉａ （Ｓｉｅｂ． ｅｔ Ｚｕｃｃ．） Ｆ． Ｖｉｌｌ．）、ヤマコウバシ（Ｌｉｎｄｅｒａ ｇｌａｕｃａ Ｂｌｕｍｅ）、ダンコウバイ（Ｌｉｎｄｅｒａ ｏｂｔｕｓｉｌｏｂａ Ｂｌｕｍｅ）、シロモジ（Ｌｉｎｄｅｒａ ｔｒｉｌｏｂａ （Ｓｉｅｂ．ｅｔ Ｚｕｃｃ．）Ｂｌｕｍｅ）を挙げることができ、中でもクロモジ（Ｌｉｎｄｅｒａ ｕｍｂｅｌｌａｔａ Ｔｈｕｎｂ．）が好ましい。 Although it does not specifically limit as a plant which belongs to the black genus (Lindera) which concerns on this invention, For example, a black moji (Lindera umbellata Thunb.), An American black moji (Lindera benzoin (L.) Blume), a tender oyster (Lindera streamnifolia. Zuccc.) F. Vill.), Dermato glauca Blume, Lindera obtusiloba Blume, Lindera triloba (Sieb. Et Zucc. Is preferred.
本発明に係るイヌタデ属（Ｐｅｒｓｉｃａｒｉａ）に属する植物としては、特に限定されないが、例えば、アイ（Ｐｅｒｓｉｃａｒｉａ ｔｉｎｃｔｏｒｉａ （Ｌｏｕｒ．） Ｈ． Ｇｒｏｓｓ）、ヤナギタデ（Ｐｅｒｓｉｃａｒｉａ ｈｙｄｒｏｐｉｐｅｒ （Ｌ．） Ｓｐａｃｈ）、オオイヌタデ（Ｐｅｒｓｉｃａｒｉａ ｌａｐａｔｈｉｆｏｌｉａ （Ｌ．） Ｓ． Ｆ． Ｇｒａｙ）、オオケタデ（Ｐｅｒｓｉｃａｒｉａ ｏｒｉｅｎｔａｌｉｓ （Ｌ．） Ａｓｓｅｎｏｖ）、ツルソバ（Ｐｅｒｓｉｃａｒｉａ ｃｈｉｎｅｎｓｉｓ （Ｌ．） Ｎａｋａｉ）、ミゾソバ（Ｐｅｒｓｉｃａｒｉａ ｔｈｕｎｂｅｒｇｉｉ （Ｓｉｅｂ． ｅｔ Ｚｕｃｃ．） Ｈ． Ｇｒｏｓｓ）を挙げることができ、中でもアイ（Ｐｅｒｓｉｃａｒｉａ ｔｉｎｃｔｏｒｉａ （Ｌｏｕｒ．） Ｈ． Ｇｒｏｓｓ）が好ましい。 The plant belonging to the genus Persicaria according to the present invention is not particularly limited, and examples thereof include, for example, Ai (Persicaria tinctoria (Lour.) H. Gross), Yanagitade (Persicaria hydropiper (L.) a spa de, (L.) S. F. Gray, Ossade (Persicaria orientalis (L.) Assenov), Persicaria chinensis (L.) Nakai, Persicaria thunbergi. Ai (Persicaria tinctoria) (Lour.) H. Gross) is preferred.
本発明に係るギシギシ属（Ｒｕｍｅｘ）に属する植物としては、特に限定されないが、例えば、キブネダイオウ（Ｒｕｍｅｘ ｎｅｐａｌｅｎｓｉｓ Ｓｐｒｅｎｇ．）、スイバ（Ｒｕｍｅｘ ａｃｅｔｏｓａ Ｌ．）、ヒメスイバ（Ｒｕｍｅｘ ａｃｅｔｏｓｅｌｌａ Ｌ．）、ギシギシ（Ｒｕｍｅｘ ｊａｐｏｎｉｃｕｓ Ｈｏｕｔｔ．）、ナガバギシギシ（Ｒｕｍｅｘ ｃｒｉｓｐｕｓ Ｌ．）を挙げることができ、中でもキブネダイオウ（Ｒｕｍｅｘ ｎｅｐａｌｅｎｓｉｓ Ｓｐｒｅｎｇ．）が好ましい。 The plant belonging to the genus Rumex according to the present invention is not particularly limited. For example, the plant is Rumex nepalensis Spring., Sorrel (Rumex acetosella L.), Rumex acetosella L., Rumex ap. Houtt.) And Nagabagishigishi (Rumex crispus L.) can be mentioned, and among these, the red-breasted (Rumex nepalensis Spring.) Is preferable.
本発明に係るミズヒキ属（Ａｎｔｅｎｏｒｏｎ）に属する植物としては、特に限定されないが、例えば、ミズヒキ（Ａｎｔｅｎｏｒｏｎ ｆｉｌｉｆｏｒｍｅ （Ｔｈｕｎｂ．） Ｒｏｂｅｒｔｙ ｅｔ Ｖａｕｔｉｅｒ）、シンミズヒキ（Ａｎｔｅｎｏｒｏｎ ｎｅｏｆｉｌｉｆｏｒｍｅ （Ｎａｋａｉ） Ｈａｒａ）を挙げることができ、中でもミズヒキ（Ａｎｔｅｎｏｒｏｎ ｆｉｌｉｆｏｒｍｅ （Ｔｈｕｎｂ．） Ｒｏｂｅｒｔｙ ｅｔ Ｖａｕｔｉｅｒ）が好ましい。 The plant belonging to the genus Antenoron according to the present invention is not particularly limited, and examples thereof include an antleron filiforme (Thunb.) Roberty et Vautier and an antleron neofiliform (Naka). Among them, Mizuki (Antenoron film (Thunb.) Roberty et Vautier) is preferable.
本発明に係るアブラギリ属（Ａｌｅｕｒｉｔｅｓ）に属する植物としては、特に限定されないが、例えば、ククイノキ（Ａｌｅｕｒｉｔｅｓ ｍｏｌｕｃｃａｎａ （Ｌ．） Ｗｉｌｌｄ．）、アブラギリ（Ａｌｅｕｒｉｔｅｓ ｃｏｒｄａｔａ （Ｔｈｕｎｂ） Ｒ．Ｂｒ． ｅｘ Ｓｔｅｕｄ．）、シナアブラギリ（Ａｌｅｕｒｉｔｅｓ ｆｏｒｄｉｉ Ｈｅｍｓｌ．）、カントンアブラギリ（Ａｌｅｕｒｉｔｅｓ ｍｏｎｔａｎａ （Ｌｏｕｒ．） Ｗｉｌｓ．）を挙げることができ、中でもククイノキ（Ａｌｅｕｒｉｔｅｓ ｍｏｌｕｃｃａｎａ （Ｌ．） Ｗｉｌｌｄ．）が好ましい。 Although it does not specifically limit as a plant which belongs to the genus Abralite (Aurelites) which concerns on this invention, For example, Akuriteki (Aluretes molucana (L.) Wild.), Aburagiri (Aurerites corda (Thunb) R. Br. Ex Steud.), Examples thereof include Aurelites fordii Hemsl. And Canton abragiri (Aleurites montana (Lour.) Wils.). Among them, cucumber (Aurelites moluccina (L.) Wild.) Is preferable.
本発明に係るアカシア属（Ａｃａｃｉａ）に属する植物としては、特に限定されないが、例えば、アセンヤクノキ（Ａｃａｃｉａ ｃａｔｅｃｈｕ Ｗｉｌｌｄ．）、リウコフロエアアカシア（Ａｃａｃｉａ ｌｅｕｃｏｐｈｌｏｅａ Ｗｉｌｌｄ．）、ミモサアカシア（Ａｃａｃｉａ ｄｅｃｕｒｒｅｎｓ Ｗｉｌｌｄ．）、モリシマアカシア（Ａｃａｃｉａ ｍｅａｒｎｓｉｉ Ｄｅ Ｗｉｌｄ．）、アラビアゴムノキ（Ａｃａｃｉａ ｓｅｎｅｇａｌ （Ｌ．） Ｗｉｌｌｄ．）を挙げることができ、中でもアセンヤクノキ（Ａｃａｃｉａ ｃａｔｅｃｈｕ Ｗｉｌｌｄ．）、リウコフロエアアカシア（Ａｃａｃｉａ ｌｅｕｃｏｐｈｌｏｅａ Ｗｉｌｌｄ．）が好ましい。 Although it does not specifically limit as a plant which belongs to the genus Acacia (Acacaia) which concerns on this invention, For example, acacia catechu (Acacia catchu Wild.), Ryukyufurea acacia (Acacia leukophloea Wild.), Mimosa acacia (Acacia dec. , Morishima Acacia (Acacia mearnsi De Wild.), And Arabia gum (Acacia senegal (L.) Wild.), Among which Acacia catchu Wild (.) And Riuco flocaia acacia (le. preferable.
本発明に係るヒシ属（Ｔｒａｐａ）に属する植物としては、特に限定されないが、例えば、ツノナシビシ（Ｔｒａｐａ ａｃｏｒｎｉｓ Ｎａｋａｎｏ）、ヒメビシ（Ｔｒａｐａ ｉｎｃｉｓａ Ｓｉｅｂ. ｅｔ Ｚｕｃ.）、ヒシ（Ｔｒａｐａ ｊａｐｏｎｉｃａ Ｆｌｅｒｏｖ）、トウビシ（Ｔｒａｐａ ｂｉｓｐｉｎｏｓａ Ｒｏｘｂ．）、トラパ・ナタンス（Ｔｒａｐａ ｎａｔａｎｓ Ｌ．）、オニビシ（Ｔｒａｐａ ｎａｔａｎｓ Ｌ．ｖａｒ．ｊａｐｏｎｉｃａ Ｎａｋａｉ ）を挙げることができ、中でもヒシ（Ｔｒａｐａ ｊａｐｏｎｉｃａ Ｆｌｅｒｏｖ）、トウビシ（Ｔｒａｐａ ｂｉｓｐｉｎｏｓａ Ｒｏｘｂ．）、オニビシ（Ｔｒａｐａ ｎａｔａｎｓ Ｌ．ｖａｒ．ｊａｐｏｎｉｃａ Ｎａｋａｉ ）が好ましい。 The plant belonging to the genus Trapa according to the present invention is not particularly limited, and examples thereof include Trapa cornicus Nakano, Japanese tiger beetle (Trapa incisa Sieb. Et Zuc.), Japanese horsetail (Trapa japonica flavi). bispinosa Roxb.), Trapa natans L., Onibibishi (Trapa Natans L. var. japonica Nakai), among others, Japanese horse mackerel (Trapa japica Frev), p. Trapanatans L. var. Japonica Nakai) is preferred.
本発明に係るエウゲニア属（Ｅｕｇｅｎｉａ）に属する植物としては、特に限定されないが、例えば、ピタンガ（Ｅｕｇｅｎｉａ ｕｎｉｆｌｏｒａ Ｌ．）、タイワンアデク（Ｅｕｇｅｎｉａ ｆｏｒｍｏｓａｎａ Ｈａｙａｔａ），セイロンアデク（Ｅｕｇｅｎｉａ ｓｐｉｃａｔａ Ｌａｍ．）を挙げることができ、中でもピタンガ（Ｅｕｇｅｎｉａ ｕｎｉｆｌｏｒａ Ｌ．）が好ましい。 Although it does not specifically limit as a plant which belongs to Eugenia genus (Eugenia) which concerns on this invention, For example, Pitanga (Eugenia uniflora L.), Taiwan adek (Eugenia formosana Hayata), Ceylon adek (Eugenia spicata L.) are mentioned. Among them, Pitanga (Eugenia uniflora L.) is preferable.
本発明に係るナツフジ属（Ｍｉｌｌｅｔｔｉａ）に属する植物としては、特に限定されないが、例えば、ムラサキナツフジ（Ｍｉｌｌｅｔｔｉａ ｒｅｔｉｃｕｌａｔａ Ｂｅｎｔｈ．）、ミレッティア・ニティダ（Ｍｉｌｌｅｔｔｉａ ｎｉｔｉｄａ Ｂｅｎｔｈ．）を挙げることができ、中でもムラサキナツフジ（Ｍｉｌｌｅｔｔｉａ ｒｅｔｉｃｕｌａｔａ Ｂｅｎｔｈ．）が好ましい。 The plant belonging to the genus Millettia according to the present invention is not particularly limited, and examples thereof include Murasakitia fuji (Milletia reticulata Benth.) And Millettia nitida Benth. Fuji (Milletcia reticulara Benth.) Is preferred.
本発明に係るミズキ属（Ｃｏｒｎｕｓ）に属する植物としては、特に限定されないが、例えば、サンシュユ（Ｃｏｒｎｕｓ ｏｆｆｉｃｉｎａｌｉｓ Ｓｉｅｂ． ｅｔ Ｚｕｃｃ．）、セイヨウサンシュユ（Ｃｏｒｎｕｓ ｍａｓ Ｌ．）、ヤマボウシ（Ｃｏｒｎｕｓｋｏｕｓａ Ｂｕｅｒｇ． ｅｘ Ｈａｎｃｅ）、ミズキ（Ｃｏｒｎｕｓｃｏｎｔｒｏｖｅｒｓａ Ｈｅｍｓｌ．）を挙げることができ、中でもサンシュユ（Ｃｏｒｎｕｓ ｏｆｆｉｃｉｎａｌｉｓ Ｓｉｅｂ． ｅｔ Ｚｕｃｃ．）が好ましい。 The plant belonging to the genus Cornus according to the present invention is not particularly limited, and examples thereof include Cornus officinalis Sieb. Et Zucc., Cornus mas L., Cornusko Buane. , And dogwood (Cornus contolosa Hemsl.) Can be mentioned, and among them, Sangyuyu (Cornus officinalis Sieb. Et Zucc.) Is preferable.
本発明に係るビンロウ属（Ａｒｅｃａ）に属する植物としては、特に限定されないが、例えば、ビンロウジュ（Ａｒｅｃａ ｃａｔｅｃｈｕ Ｌ．）が好ましい。 Although it does not specifically limit as a plant which belongs to the genus (Areca) which concerns on this invention, For example, Areca (Areca catchu L.) is preferable.
本発明に係るヤマモモ属（Ｍｙｒｉｃａ）に属する植物としては、特に限定されないが、例えば、シロコヤマモモ（Ｍｙｒｉｃａ ｃｅｒｉｆｅｒａ Ｌ．）、ヤマモモ（Ｍｙｒｉｃａ ｒｕｂｒａ Ｓｉｅｂ． ｅｔ Ｚｕｃｃ．）、カロライナヤマモモ（Ｍｙｒｉｃａ ｃａｒｏｌｉｎｅｎｓｉｓ Ｍｉｌｌ．）を挙げることができ、中でもシロコヤマモモ（Ｍｙｒｉｃａ ｃｅｒｉｆｅｒａ Ｌ．）が好ましい。 The plant belonging to the genus Myrica according to the present invention is not particularly limited, but examples thereof include white bayberry (Myrica cerifera L.), bayberry (Myrica rubra Sieb. Et Zucc.), And Carolina bayberry (Myrica). Among them, Myrica cerifera L. is preferable.
上記の植物の中で、ヤツデアオギリ、チャンチンモドキ、マンゴー、ヌルデ、マンゴスチン、クロモジ、アイ、キブネダイオウ、ミズヒキ、ククイノキ、アセンヤクノキ、リウコフロエアアカシア、ヒシ、ピタンガ、ムラサキナツフジ、サンシュユ、ビンロウジュ、シロコヤマモモからなる植物群から選ばれる植物からの抽出エキスが特に好ましい。
植物エキスの製造方法
本発明に係る植物エキスの製造には、上記植物の各部位、例えば、花、花穂、果皮、果実、果肉、茎、葉、枝、枝葉、幹、樹皮、根茎、根皮、根、種子、虫えい、心材、地上部、地下部又は全草を用いることができる。
Among these plants An extract extracted from a plant selected from the plant group consisting of bayberry is particularly preferred.
Method for producing plant extract For production of the plant extract according to the present invention, each part of the above-mentioned plant, for example, flower, spike, fruit skin, fruit, pulp, stem, leaf, branch, branch leaf, trunk, bark, Rhizome, root bark, root, seed, insect gill, heartwood, above-ground part, underground part or whole plant can be used.
本発明に係る植物エキスの製造方法は、特に限定されず、例えば、通常用いられる方法により製造することができる。具体的には、植物の各部位をそのまま又は適当な大きさに切断し、搾汁又は溶媒で抽出することにより製造することができる。抽出溶媒としては、例えば、水、各種有機溶媒、あるいはそれらの混合溶媒を用いることができる。抽出のための有機溶媒としては、例えば、低級アルコール（例えば、メタノール、エタノール）、クロロホルム、酢酸エチル、ｎ−ヘキサンを挙げることができる。抽出溶媒の中で、特に水、メタノール、エタノールが好ましい。また、これらの溶媒を一種又は二種以上混合して用いることもできる。 The manufacturing method of the plant extract which concerns on this invention is not specifically limited, For example, it can manufacture by the method used normally. Specifically, it can be produced by cutting each part of a plant as it is or into an appropriate size and extracting with a juice or a solvent. As the extraction solvent, for example, water, various organic solvents, or a mixed solvent thereof can be used. Examples of the organic solvent for extraction include lower alcohols (for example, methanol, ethanol), chloroform, ethyl acetate, and n-hexane. Among the extraction solvents, water, methanol, and ethanol are particularly preferable. These solvents can be used alone or in combination.
抽出溶媒の使用量は、用いる植物原料や抽出溶媒等により異なるが、重量比で、１：２〜１：３０（植物原料：抽出溶媒）の範囲内が適当であり、１：３〜１：２０の範囲内が好ましく、１：５〜１：１０の範囲内がより好ましい。抽出時間は、1時間〜１５日の範囲内が適当である。抽出温度は、５〜１００℃の範囲内が適当である。抽出方法については特に制限されず、バッチ抽出、カラムを用いた連続抽出等、任意の方法を適用することができる。 The amount of the extraction solvent to be used varies depending on the plant raw material used, the extraction solvent, etc., but the weight ratio is suitably in the range of 1: 2 to 1:30 (plant raw material: extraction solvent). A range of 20 is preferable, and a range of 1: 5 to 1:10 is more preferable. The extraction time is suitably in the range of 1 hour to 15 days. The extraction temperature is suitably in the range of 5 to 100 ° C. The extraction method is not particularly limited, and any method such as batch extraction or continuous extraction using a column can be applied.
得られた植物エキスは、そのままの状態で用いることもできるが、必要に応じ、その活性に影響のない範囲内で更に精製処理を加えてもよい。このような精製処理は、通常の方法によって行えばよく、例えば、植物エキスを常法によりろ過することにより行うことができる。その後、得られたろ液を減圧濃縮、凍結乾燥して、本発明に係る植物エキスとすることができる。
本発明阻害剤、本発明組成物
本発明阻害剤は、上記のようにして得られた植物エキスを1種又は2種以上含有するものである。本発明阻害剤は、例えば、上記のようにして得られた植物エキスを、そのまま又は担体として使用することのできる素材と混合し、次いで、常法により粉末状、塊状、液状などの各種形態に加工することにより製造することができる。
The obtained plant extract can be used as it is, but if necessary, further purification treatment may be added within a range that does not affect its activity. Such a purification process may be performed by a normal method, for example, by filtering a plant extract by a conventional method. Thereafter, the filtrate obtained can be concentrated under reduced pressure and freeze-dried to obtain the plant extract according to the present invention.
The inhibitor of the present invention, the composition of the present invention The inhibitor of the present invention contains one or more plant extracts obtained as described above. The inhibitor of the present invention is prepared, for example, by mixing the plant extract obtained as described above with a raw material that can be used as it is or as a carrier, and then by various conventional methods such as powder, lump, and liquid. It can be manufactured by processing.
本発明組成物は、本発明阻害剤を含有するものである。本発明組成物は、例えば、本発明阻害剤をそのまま用いることもできるし、又は、本発明阻害剤と、担体として使用することのできる素材とを混合し、次いで、常法により粉末状、塊状、液状などの各種形態に加工することにより製造することができる。 The composition of the present invention contains the inhibitor of the present invention. In the composition of the present invention, for example, the inhibitor of the present invention can be used as it is, or the inhibitor of the present invention and a material that can be used as a carrier are mixed, and then powdered or massive by a conventional method It can be produced by processing into various forms such as liquid.
本発明阻害剤及び本発明組成物には、任意に医薬上又は食品上許容される添加物を配合することができる。かかる添加剤としては、例えば、結合剤、崩壊剤、滑沢剤、分散剤、懸濁剤、乳化剤、緩衝剤、酸化防止剤、賦形剤、界面活性剤、紫外線防止剤、金属イオン封鎖剤、増粘剤、防腐剤、抗菌剤、保湿剤、色素を挙げることができ、これらの１種又は２種以上を適当量使用することができる。 The inhibitor of the present invention and the composition of the present invention can optionally contain a pharmaceutically or food acceptable additive. Examples of such additives include binders, disintegrants, lubricants, dispersants, suspending agents, emulsifiers, buffers, antioxidants, excipients, surfactants, UV inhibitors, and sequestering agents. , Thickeners, preservatives, antibacterial agents, humectants, and pigments, and one or more of these may be used in appropriate amounts.
本発明阻害剤及び本発明組成物における植物エキスの配合量は、特に限定されず、０．０１重量％（以下、単に「％」という）以上、好ましくは、０．０５〜５０％である。
本発明阻害剤及び本発明組成物は、常法により、錠剤、散剤、顆粒剤、カプセル剤、液剤、シロップ剤、ドロップ錠、トニック、ローション、軟膏、クリーム等の剤型に適宜調製することができる。
The compounding quantity of the plant extract in this invention inhibitor and this invention composition is not specifically limited, It is 0.01 weight% (henceforth only "%") or more, Preferably, it is 0.05 to 50%.
The inhibitor of the present invention and the composition of the present invention can be suitably prepared into dosage forms such as tablets, powders, granules, capsules, solutions, syrups, drop tablets, tonics, lotions, ointments, creams, etc. by conventional methods. it can.
本発明阻害剤及び本発明組成物の摂取量は、含有されている植物エキスの種類、剤型、投与対象者の年齢、体重等により異なるが、通常、成人１日当り、植物エキスの重量として、０．１〜１００ｇの範囲内とするのが適当であり、１〜６０ｇの範囲内とするのが好ましいが、必ずしもこの範囲に限られるものではない。かかる１日当りの摂取量は、１回で摂取してもよく、また、２〜４回に分割して摂取してもよい。 The amount of intake of the inhibitor of the present invention and the composition of the present invention varies depending on the type of plant extract contained, the dosage form, the age of the administration subject, the body weight, etc. Although it is appropriate to set it in the range of 0.1-100g, and it is preferable to set it in the range of 1-60g, it is not necessarily restricted to this range. Such daily intake may be taken once, or may be taken divided into 2 to 4 times.
本発明阻害剤及び本発明組成物は、優れたメイラード反応阻害作用を有するため、老化に伴って生じる現象、例えば、白内障、軟骨の弾力低下、皮膚の老化（皮膚の弾力低下、しわやたるみの原因となるコラーゲンの架橋形成、肌のくすみの原因となる色素沈着等）の抑制に用いることができる。また、本発明阻害剤は、メイラード反応が関与することが知られている、糖尿病合併症（例えば、心筋梗塞、糖尿病性腎症、糖尿病性網膜症、糖尿病性神経症）の予防又は治療に用いることもできる。
経口剤
本発明経口剤は、本発明阻害剤を含有する、経口摂取が可能な組成物を意味する。本発明経口剤は、本発明阻害剤をそのまま又は必要に応じて、経口剤を製造する際に用いられる医薬上又は食品上許容される添加剤とを適量配合したものを、常法により製剤化することにより得ることができる。かかる添加剤としては、賦形剤、充填剤、増量剤、結合剤、崩壊剤、界面活性剤、調味料、香料、滑沢剤等を挙げることができる。
The inhibitor of the present invention and the composition of the present invention have an excellent Maillard reaction inhibitory action, and therefore, phenomena that occur with aging, such as cataracts, reduced elasticity of cartilage, skin aging (reduced elasticity of skin, wrinkles and sagging) It can be used to suppress the formation of collagen cross-linking, pigmentation that causes dull skin, and the like. The inhibitor of the present invention is used for the prevention or treatment of diabetic complications (eg, myocardial infarction, diabetic nephropathy, diabetic retinopathy, diabetic neuropathy) that are known to involve the Maillard reaction. You can also.
Oral preparation The oral preparation of the present invention means a composition containing the inhibitor of the present invention and capable of being taken orally. The oral preparation of the present invention is formulated by a conventional method by blending an appropriate amount of the inhibitor of the present invention as it is or if necessary with a pharmaceutically or food acceptable additive used in the production of the oral preparation. Can be obtained. Examples of such additives include excipients, fillers, extenders, binders, disintegrants, surfactants, seasonings, fragrances, lubricants, and the like.
本発明経口剤の製剤化に際して、他の生理機能を有する素材を配合することもできる。本発明経口剤の剤型は特に限定されず、例えば、錠剤、散剤、顆粒剤、カプセル剤、液剤、シロップ剤、ドロップ剤を挙げることができる。 In formulating the oral preparation of the present invention, materials having other physiological functions can be blended. The dosage form of the oral preparation of the present invention is not particularly limited, and examples thereof include tablets, powders, granules, capsules, solutions, syrups, and drops.
本発明経口剤における本発明阻害剤の含有量としては、含有されている本発明に係る植物エキスの種類、剤型等に合わせて適宜調製すればよいが、例えば、製剤全量中、本発明阻害剤を固形分換算で、０．５〜６０％、好ましくは３〜５０％、特に好ましくは５〜１０％の範囲内で配合すれば良い。 The content of the inhibitor of the present invention in the oral preparation of the present invention may be appropriately adjusted according to the type, dosage form, etc. of the plant extract according to the present invention. What is necessary is just to mix | blend an agent in 0.5-60% in conversion of solid content, Preferably it is 3-50%, Most preferably, it may mix | blend within the range of 5-10%.
本発明経口剤の摂取量は、含有されている本発明に係る植物エキスの種類、剤型、投与対象者の年齢、体重等により異なるが、通常、成人１日当り、本発明に係る植物エキスの重量として、０．１〜１００ｇの範囲内とするのが適当であり、１〜６０ｇの範囲内とするのが好ましいが、必ずしもこの範囲に限られるものではない。かかる１日当りの摂取量は、１回で摂取してもよく、また、２〜４回に分割して摂取してもよい。
外用剤
本発明外用剤は、本発明阻害剤を含有する、外用で使用することが可能な組成物を意味する。
The intake of the oral preparation of the present invention varies depending on the type, dosage form, age, weight, etc. of the plant extract according to the present invention contained, but usually, the daily dose of the plant extract according to the present invention The weight is suitably within the range of 0.1 to 100 g, and preferably within the range of 1 to 60 g, but is not necessarily limited to this range. Such daily intake may be taken once, or may be taken divided into 2 to 4 times.
External preparation The external preparation of the present invention means a composition that contains the inhibitor of the present invention and can be used for external use.
本発明外用剤は、本発明阻害剤をそのまま又は必要に応じて、外用剤を製造する際に用いられる医薬上、化粧上又は食品上許容される添加剤とを適量配合したものを常法により製剤化することにより得ることができる。かかる添加剤としては、軟膏用基材、アルコール、多価アルコール、水溶性高分子、酸化防止剤、ｐH調整剤、紫外線防止剤、金属イオン封鎖剤、増粘剤、界面活性剤、精製水、防腐剤、抗菌剤、油剤、高級脂肪酸、脂肪酸エステル、保湿剤、色素、ビタミン類、アミノ酸類等を挙げることができる。 The external preparation of the present invention is prepared by blending an appropriate amount of a pharmaceutical, cosmetically or food-acceptable additive used when producing the external preparation, as it is or as necessary, with the inhibitor of the present invention. It can be obtained by formulating. Such additives include base materials for ointments, alcohols, polyhydric alcohols, water-soluble polymers, antioxidants, pH regulators, UV inhibitors, sequestering agents, thickeners, surfactants, purified water, Preservatives, antibacterial agents, oil agents, higher fatty acids, fatty acid esters, humectants, pigments, vitamins, amino acids and the like can be mentioned.
さらに、本発明阻害剤を、公知の医薬部外品、化粧品に配合して本発明外用剤として用いることもできる。 Furthermore, this invention inhibitor can also be mix | blended with a well-known quasi-drug and cosmetics, and can also be used as this invention external preparation.
本発明外用剤には、本発明阻害剤のほか、老化抑制効果を高めるための成分を更に配合したり、他の生理機能を有する素材を配合することもできる。かかる成分としては、例えば、紫外線防止剤、酸化防止剤、保湿剤、細胞賦活剤、血流促進剤を挙げることができる。これらの1種又は２種以上を適当量使用することができる。 In addition to the inhibitor of the present invention, the external preparation of the present invention can be further blended with components for enhancing the effect of inhibiting aging, or can be blended with a material having other physiological functions. Examples of such components include ultraviolet light inhibitors, antioxidants, humectants, cell activators, and blood flow promoters. One or two or more of these can be used in an appropriate amount.
本発明外用剤の具体的な使用態様としては、特に限定されず、例えば、化粧水、乳液、クリーム、軟膏、ローション、オイル、パックを挙げることができる。 Specific usage modes of the external preparation of the present invention are not particularly limited, and examples thereof include skin lotion, emulsion, cream, ointment, lotion, oil, and pack.
本発明外用剤における本発明阻害剤の含有量としては、含有されている本発明に係る植物エキスの種類、剤型等に合わせて適宜調製すればよいが、例えば、製剤全量中、固形分換算で、０．０００１〜３０％、好ましくは０．００１〜２５％、特に好ましくは０．５〜２０％の範囲で配合すればよい。 The content of the inhibitor of the present invention in the external preparation of the present invention may be appropriately adjusted according to the type, dosage form, etc. of the plant extract according to the present invention. And 0.0001 to 30%, preferably 0.001 to 25%, particularly preferably 0.5 to 20%.
本発明外用剤の使用量は、含有されている本発明に係る植物エキスの種類、剤型、投与対象者の年齢、体重等により異なるが、通常、成人１日当り、植物エキスの重量として、０．１〜１００ｇの範囲内とするのが適当であり、１〜６０ｇの範囲内とするのが好ましいが、必ずしもこの範囲に限られるものではない。かかる１日当りの使用量は、１回で使用してもよく、また、２〜４回に分割して使用してもよい。
飲食品
本発明飲食品は、本発明阻害剤と公知の食材又は飲食品とを混合して、常法により、食品に加工することにより得ることができる。
The amount of the external preparation for use in the present invention varies depending on the type, dosage form, age, body weight, etc. of the plant extract according to the present invention contained, but it is usually 0 per day per adult as the weight of the plant extract. It is suitable to be within the range of 1 to 100 g, and preferably within the range of 1 to 60 g, but is not necessarily limited to this range. Such daily use amount may be used once or may be divided into 2 to 4 times.
Food / beverage products The food / beverage products of the present invention can be obtained by mixing the inhibitor of the present invention with known foods or foods / beverages and processing them into foods by conventional methods.
本発明飲食品の形態は特に限定されず、例えば、粉末状、塊状、液状、シロップ状、ゼリー状を挙げることができる。 The form of this invention food / beverage products is not specifically limited, For example, a powder form, lump shape, liquid form, syrup form, and jelly form can be mentioned.
本発明飲食品には、食品上許容される他の成分を配合することができる。かかる成分としては、例えば、栄養素、賦形剤、増量剤、甘味料、香味剤、着色剤、防腐剤、乳化剤、可溶化剤、多価アルコール、有機酸、無機酸、水溶性高分子を挙げることができる。これらの1種又は2種以上を適当量使用することができる。 The food and drink according to the present invention may contain other ingredients that are acceptable in food. Examples of such components include nutrients, excipients, extenders, sweeteners, flavoring agents, coloring agents, preservatives, emulsifiers, solubilizers, polyhydric alcohols, organic acids, inorganic acids, and water-soluble polymers. be able to. One or more of these can be used in an appropriate amount.
本発明飲食品の種類としては、例えば、飲料（清涼飲料、乳飲料、ジュース、茶類等）、粉末飲料（粉末ジュース、粉末スープ等）、練製品（畜肉ソーセージ、魚肉ソーセージ、かまぼこ、竹輪等）、惣菜（オムレツ、卵焼、ハンバーグ、コロッケ、ミーとボール、酢の物、酢豚、サラダ、餃子、しゅうまい、ロールキャベツ、豆腐、筑前煮、煮豆、ひじき煮、唐揚、天ぷら、フライ、茶碗蒸、胡麻和え、サラダ、カレー、シチュー、スープ、チャーハン、おにぎり、餅、ふりかけ、味噌汁等）、麺類（うどん、そうめん、そば、スパゲッティ、マカロニ、ラーメン等）、調理パン（ハンバーガー、ホットドッグ、サンドイッチ等）、パン（食パン、フランスパン等）、菓子（ケーキ、クッキー、ウエハース、クレープ、ヨーグルト、プリン、キャンディー、ガム、アイスクリーム、キャラメル、チョコレート、ドーナツ、せんべい、ようかん、ういろう、もなか、まんじゅう、大福餅、おはぎ、団子、甘納豆、中華まん等）を挙げることができる。この他、マヨネーズ、サラダドレッシング等も挙げることができる。 Examples of the types of the food and drink according to the present invention include beverages (soft drinks, milk drinks, juices, teas, etc.), powdered drinks (powder juices, powder soups, etc.), paste products (livestock sausages, fish sausages, kamaboko, bamboo rings, etc.) ), Side dish (omelette, fried egg, hamburger, croquette, me and ball, vinegared food, sour pork, salad, dumplings, cucumber, roll cabbage, tofu, boiled chikuzen, boiled beans, hijiki boiled, fried chicken, tempura, fried, chawanmushi, sesame sauce , Salad, curry, stew, soup, fried rice, rice balls, rice bowl, sprinkle, miso soup, etc.), noodles (udon, somen, soba, spaghetti, macaroni, ramen, etc.), cooked bread (burger, hot dog, sandwich, etc.), bread (Bread, French bread, etc.), confectionery (cake, cookies, wafers, crepes, yogurt, pudding) Candy, it can be gum, ice cream, caramel, chocolate, donuts, crackers, jelly, Uiro, during, buns, Daifukumochi, Ohagi, dumpling, amanattō, be given the Chinese steamed buns, etc.). In addition, mayonnaise, salad dressing, etc. can be mentioned.
本発明飲食品への本発明阻害剤の添加量は、添加剤の有無や食品の種類等により異なるが、含有されている本発明に係る植物エキスの固形分換算で０．０１〜５０％の範囲内とするのが適当であり、０．１〜３０％の範囲内とするのが好ましいが、必ずしもこの範囲に限られるものではない。 The amount of the inhibitor of the present invention added to the present food or drink varies depending on the presence or absence of the additive and the type of food, but is 0.01 to 50% in terms of solid content of the plant extract according to the present invention. It is suitable to be within the range and is preferably within the range of 0.1 to 30%, but is not necessarily limited to this range.
本発明飲食品の摂取量は、摂取者の性別、年齢、体重等によって異なる。かかる摂取量は、成人１日当り、本発明に係る植物エキスの重量として、０．１〜１００ｇの範囲内とするのが適当であり、１〜６０ｇの範囲内とするのが好ましいが、必ずしもこの範囲に限られるものではない。かかる１日当りの使用量は、１回で使用してもよく、また、２〜４回に分割して使用してもよい。 The intake of the food and drink according to the present invention varies depending on the sex, age, weight, etc. of the user. Such intake is suitably within the range of 0.1 to 100 g, preferably within the range of 1 to 60 g, as the weight of the plant extract according to the present invention per adult day. It is not limited to the range. Such daily use amount may be used once or may be divided into 2 to 4 times.
以下に参考例、抽出例、試験例、実施例を掲げて本発明をさらに詳述する。但し、本発明が下記実施例に限定されないことは言うまでもない。
参考例１ ケイシエキス（５０％エタノール抽出）の製造
ケイシ粉末（前忠株式会社製）５ｇを５０％エタノール１００mLに浸漬し、常温で５日間静置した後、濃縮、凍結乾燥し、ケイシエキスを得た。
抽出例１ 各植物エキス（メタノール抽出）の製造
表１に記載の番号１〜１９の各植物を風乾後、６０℃で一晩乾燥させた。ブレンダーにて粉砕後、得られた粉砕物 １００ｇをメタノール５００ｍLに浸漬し、常温で一週間静置した。得られた抽出液をろ過して得られたろ液はロータリーエバポレーターでメタノールを留去して乾固し、番号１〜１９の各植物エキスを得た。
Hereinafter, the present invention will be described in more detail with reference examples, extraction examples, test examples, and examples. However, it goes without saying that the present invention is not limited to the following examples.
Reference Example 1 Production of cinnamon extract (50% ethanol extraction) 5 g of cinnamon powder (manufactured by Maechu Co., Ltd.) was immersed in 100 mL of 50% ethanol, allowed to stand at room temperature for 5 days, and then concentrated and freeze-dried to obtain cinnamon extract. .
Extraction Example 1 Production of each plant extract (methanol extraction) Each plant of Nos. 1 to 19 listed in Table 1 was air-dried and then dried at 60 ° C overnight. After pulverization with a blender, 100 g of the obtained pulverized product was immersed in 500 mL of methanol and allowed to stand at room temperature for one week. The filtrate obtained by filtering the extract obtained was evaporated to dryness by distilling off methanol with a rotary evaporator to obtain each plant extract numbered 1-19.
試験例１ メイラード反応阻害活性の測定
参考例１、抽出例１で得られた各植物エキスはジメチルスルホキシド（ＤＭＳＯ）に３０ｍｇ／ｍＬとなるように溶解した。なお、参考例１のケイシエキスを陽性対照として用いた。また、陰性対照には、検体の代わりにＤＭＳＯを用いた。
Test Example 1 Measurement of Maillard Reaction Inhibitory Activity Each plant extract obtained in Reference Example 1 and Extraction Example 1 was dissolved in dimethyl sulfoxide (DMSO) at 30 mg / mL. In addition, the cinnamon extract of Reference Example 1 was used as a positive control. Moreover, DMSO was used instead of the specimen as a negative control.
各検体はＤＭＳＯで、試験溶液中の植物エキスの最終濃度が１０、５、２．５、１．２５、０．６２５μｇ／ｍＬとなるように調製した。各検体２０μＬ、１００ｍＭリン酸バッファー５００μＬ、蒸留水１８０μＬ、２Ｍグルコース溶液１００μＬ、４ｍｇ／ｍＬ ＢＳＡ溶液２００μＬを１．５ｍLマイクロテストチューブ（アズワン社製）に入れて混合し、試験溶液とした。その後、試験溶液及び陰性対照を６０℃下３０時間インキュベートした。 Each specimen was prepared with DMSO so that the final concentration of the plant extract in the test solution was 10, 5, 2.5, 1.25, and 0.625 μg / mL. 20 μL of each specimen, 500 μL of 100 mM phosphate buffer, 180 μL of distilled water, 100 μL of 2M glucose solution, and 200 μL of 4 mg / mL BSA solution were placed in a 1.5 mL micro test tube (manufactured by ASONE) and mixed to obtain a test solution. The test solution and negative control were then incubated at 60 ° C. for 30 hours.
次に、この反応液１ｍＬへトリクロロ酢酸（ＴＣＡ）１００ｍＬを添加し、４℃下、１５０００ｒｐｍで４分間遠心分離した。上清を除去後、残った沈殿物を０．２５Ｎ 水酸化ナトリウム−ＰＢＳ溶液１ｍＬにて溶解した。得られた試験溶液を、蛍光プレートリーダー（インフィニットＭ２００ＦＡＬ、５５２−８２６３１、ＴＥＣＡＮ社製）を用いて、励起波長３６０ｎｍ、蛍光波長４４０ｎｍにて蛍光測定した。 Next, 100 mL of trichloroacetic acid (TCA) was added to 1 mL of this reaction solution, and centrifuged at 15000 rpm for 4 minutes at 4 ° C. After removing the supernatant, the remaining precipitate was dissolved in 1 mL of a 0.25N sodium hydroxide-PBS solution. The obtained test solution was measured for fluorescence at an excitation wavelength of 360 nm and a fluorescence wavelength of 440 nm using a fluorescence plate reader (Infinite M200FAL, 552-82631, manufactured by TECAN).
ブランク１として、陰性対照と同組成の溶液であって、インキュベートしていないものを用いた。また、試験溶液と同組成の溶液であって、インキュベートしていないものをブランク２とした。 As blank 1, a solution having the same composition as that of the negative control and not incubated was used. Also, a solution having the same composition as the test solution and not incubated was designated as blank 2.
メイラード反応阻害活性（％）は、以下の数式に従い算出した。 Maillard reaction inhibitory activity (%) was calculated according to the following formula.
横軸に試料の濃度（ｍｇ／ｍＬ）、縦軸にメイラード反応阻害活性（％）をとった対数グラフを作成し、５０％阻害活性を示す濃度（ＩＣ50）を算出した。その結果を表２に示す。 A logarithmic graph was prepared with the horizontal axis representing the sample concentration (mg / mL) and the vertical axis representing the Maillard reaction inhibitory activity (%), and the concentration (IC 50 ) showing 50% inhibitory activity was calculated. The results are shown in Table 2.
表２に示したとおり、本発明に係る植物エキスは、強力なメイラード反応阻害作用が報告されているケイシのＩＣ50と同等またはそれ以上の阻害活性を示し、優れたメイラード反応阻害作用を有することが示された。 As shown in Table 2, the plant extract according to the present invention exhibit strong Maillard equivalent IC 50 of twig reaction inhibitory activity has been reported or more inhibitory activity, have excellent Maillard reaction inhibitory effect It has been shown.
抽出例２ アセンヤクノキおよびヌルデの植物エキスの製造
表１および２に記載の番号４（ヌルデ、虫えい）および番号１２（アセンヤクノキ、心材）について、各植物を風乾後、６０℃で一晩乾燥させ、ブレンダーにて粉砕した。得られた粉砕物 ２ｇおよび３０ｍLの各抽出溶媒（９９．５％エタノール、７０％含水エタノールまたは水）を５０ｍL容のスクリューキャップ付試験管に入れて攪拌した後、８０℃で３０分間静置した。得られた抽出液をろ過して得られたろ液はロータリーエバポレーターで濃縮乾固し、表３に記載の番号２０〜２５の各植物エキスを得た。
試験例２ メイラード反応阻害活性の測定
抽出例２で得られた各植物エキスは、試験例１の方法に従って、メイラード反応阻害活性を測定した。ただし、各植物エキスはＤＭＳＯの代わりに各抽出溶媒に溶解し、検体調製には、ＤＭＳＯの代わりに各抽出溶媒を用いた。試料溶液中の植物エキスの最終濃度は１０、５、２、０.２、０.１μｇ／ｍＬとなるよう調製した。また、陽性対照として、アセンヤクノキ（心材）およびヌルデ（虫えい）のメタノール抽出エキスを用い、陰性対照として、検体の代わりに抽出溶媒を用いた。
Extraction Example 2 Production of plant extracts of Acacia cypress and Nurde For No. 4 (Nurde, insect worm) and No. 12 (Acacia catechu, heartwood) listed in Tables 1 and 2, each plant was air-dried and dried overnight at 60 ° C. It grind | pulverized with the blender. 2 g of the obtained pulverized product and 30 mL of each extraction solvent (99.5% ethanol, 70% aqueous ethanol or water) were placed in a 50 mL test tube with a screw cap and stirred, and then allowed to stand at 80 ° C. for 30 minutes. . The filtrate obtained by filtering the obtained extract was concentrated and dried with a rotary evaporator to obtain plant extracts numbered 20 to 25 listed in Table 3.
Test Example 2 Measurement of Maillard Reaction Inhibitory Activity Each plant extract obtained in Extraction Example 2 was measured for Maillard reaction inhibitory activity according to the method of Test Example 1. However, each plant extract was dissolved in each extraction solvent instead of DMSO, and each extraction solvent was used instead of DMSO for specimen preparation. The final concentration of the plant extract in the sample solution was adjusted to 10, 5, 2, 0.2, and 0.1 μg / mL. In addition, a methanol extract of Acacia cypress (heartwood) and Nurde (insect moth) was used as a positive control, and an extraction solvent was used instead of the specimen as a negative control.
その結果を表３に示す。 The results are shown in Table 3.
表３に示したとおり、本発明に係る植物エキスは、試験例２で用いたいずれの溶媒で抽出したエキスであっても、優れたメイラード反応阻害作用を有することが示された。 As shown in Table 3, it was shown that the plant extract according to the present invention has an excellent Maillard reaction inhibitory action, even if it is an extract extracted with any solvent used in Test Example 2.
抽出例３ ヒシ属の植物エキスの製造
ヒシ（Ｔｒａｐａ ｊａｐｏｎｉｃａ Ｆｌｅｒｏｖ）の果実、トウビシ（Ｔｒａｐａ ｂｉｓｐｉｎｏｓａ Ｒｏｘｂ．）の果実および果皮、オニビシ（Ｔｒａｐａ ｎａｔａｎｓ Ｌ．ｖａｒ．ｊａｐｏｎｉｃａ Ｎａｋａｉ ）の果実および果皮について、抽出例２と同様の方法に従って植物エキスの製造を行い、各植物エキスを得た。
試験例３ メイラード反応阻害活性の測定
試験例２と同様の方法に従って、表４に記載の番号２６〜３７の各植物エキスについてメイラード反応阻害活性の測定を行った。ただし、陽性対照として、ヒシ（果実）のメタノール抽出エキスを用いた。
Extraction Example 3 Manufacture of a plant extract of the genus Hishi (Trapa japonica Flerov) fruit, trapeze (Trapa bispinosa Roxb.) Fruit and pericarp, Onibishi (Trapa natans L. var. Japonica fruit peel) According to the same method as in 2, plant extracts were produced to obtain each plant extract.
Test Example 3 Measurement of Maillard Reaction Inhibitory Activity According to the same method as in Test Example 2, Maillard reaction inhibitory activity was measured for each of the plant extracts numbered 26 to 37 shown in Table 4. However, as a positive control, a methanol extract of castor (fruit) was used.
その結果を表４に示す。 The results are shown in Table 4.
表４に示したとおり、本発明に係る植物エキスは、優れたメイラード反応阻害作用を有することが示された。 As shown in Table 4, it was shown that the plant extract according to the present invention has an excellent Maillard reaction inhibitory action.
次に、本発明阻害剤を含有する経口剤、外用剤、飲食品の実施例を示す。
実施例１ 経口剤（錠剤）の調製
以下の配合割合に従い、各成分を混合して、常法に従って錠剤を製造する。
Next, examples of oral preparations, external preparations and foods and drinks containing the inhibitor of the present invention are shown.
Example 1 Preparation of oral preparation (tablet) According to the following blending ratio, each component is mixed, and a tablet is produced according to a conventional method.
実施例２ 経口剤（顆粒剤）の調製
以下の配合割合に従い、各成分を混合して、常法に従って顆粒剤を製造する。
Example 2 Preparation of oral preparation (granule) According to the following blending ratio, each component is mixed and a granule is produced according to a conventional method.
実施例３ 経口剤（ソフトカプセル剤）の調製
以下の配合割合に従い、各成分を混合して、常法に従ってソフトカプセル剤を製造する。
Example 3 Preparation of oral preparation (soft capsule) According to the following blending ratio, each component is mixed and a soft capsule is manufactured according to a conventional method.
実施例４ 外用剤（クリーム）の調製
以下の配合割合に従い、各成分を混合して、常法に従ってクリームを製造する。
Example 4 Preparation of External Preparation (Cream) According to the following blending ratio, each component is mixed, and a cream is produced according to a conventional method.
実施例５ 外用剤（化粧水）の調製
以下の配合割合に従い、各成分を混合して、常法に従って化粧水を製造する。
Example 5 Preparation of external preparation (skin lotion) According to the following blending ratio, each component is mixed, and a skin lotion is produced according to a conventional method.
実施例６ 飲食品（飲料）の調製
以下の配合割合に従い、各成分を混合して、常法に従って飲料を製造する。
Example 6 Preparation of food / beverage product (beverage) According to the following blending ratio, each component is mixed and a drink is manufactured according to a conventional method.
実施例７ 飲食品（キャンデー）の調製
以下の配合割合に従い、各成分を混合して、常法に従ってキャンディーを製造する。
Example 7 Preparation of food and drink (candy) According to the following blending ratio, each component is mixed and a candy is manufactured according to a conventional method.
Claims (7)
A composition for preventing or treating diabetic complications, comprising the Maillard reaction inhibitor according to claim 1 or 2.
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| JP2017095492A (en) | 2017-06-01 |
| JP2014094964A (en) | 2014-05-22 |
| JP6674001B2 (en) | 2020-04-01 |
| JP6131993B2 (en) | 2017-05-24 |
| JP2015232025A (en) | 2015-12-24 |
| JP6420376B2 (en) | 2018-11-07 |
| JP2010077123A (en) | 2010-04-08 |
| JP2020090517A (en) | 2020-06-11 |
| JP5805226B2 (en) | 2015-11-04 |
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