JP2018528944A - オナプリストン中間体の製造方法 - Google Patents
オナプリストン中間体の製造方法 Download PDFInfo
- Publication number
- JP2018528944A JP2018528944A JP2018509611A JP2018509611A JP2018528944A JP 2018528944 A JP2018528944 A JP 2018528944A JP 2018509611 A JP2018509611 A JP 2018509611A JP 2018509611 A JP2018509611 A JP 2018509611A JP 2018528944 A JP2018528944 A JP 2018528944A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- excimer
- onapristone
- lamp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (9)
- 式Iの化合物に、約295nmから約320nmの波長の、エキシマDBD光源およびLEDからなる群から選択されるランプからの狭帯域周波数光を照射することを含む、式IIの化合物を製造する方法。
- 狭帯域周波数光の波長が、エキシマDBD光源からの約308nmである、請求項1に記載の方法。
- 前記ランプが、エキシマDBD光源である、請求項1に記載の方法。
- Xが、OCH2CH2Oである、請求項1に記載の方法。
- 式Iと式IIとの比が、約20:80である、請求項1に記載の方法。
- 式Iの化合物に、約295nmから約320nmの波長の、エキシマDBD光源およびLEDからなる群から選択されるランプからの狭帯域周波数光を照射することを含む、ステロイド2の製造方法。
- 狭帯域周波数光の波長が、約308nmである、請求項6に記載の方法。
- 前記ランプが、エキシマDBD光源である、請求項6に記載の方法。
- 式Iと式IIとの比が、約5〜10:90〜95%である、請求項6に記載の方法。
Priority Applications (1)
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---|---|---|---|
JP2021080411A JP2021120396A (ja) | 2015-09-25 | 2021-05-11 | オナプリストン中間体の製造方法 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562233166P | 2015-09-25 | 2015-09-25 | |
US62/233,166 | 2015-09-25 | ||
PCT/US2016/053435 WO2017053793A1 (en) | 2015-09-25 | 2016-09-23 | Methods of making onapristone intermediates |
Related Child Applications (1)
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JP2021080411A Division JP2021120396A (ja) | 2015-09-25 | 2021-05-11 | オナプリストン中間体の製造方法 |
Publications (1)
Publication Number | Publication Date |
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JP2018528944A true JP2018528944A (ja) | 2018-10-04 |
Family
ID=58387465
Family Applications (2)
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JP2018509611A Pending JP2018528944A (ja) | 2015-09-25 | 2016-09-23 | オナプリストン中間体の製造方法 |
JP2021080411A Pending JP2021120396A (ja) | 2015-09-25 | 2021-05-11 | オナプリストン中間体の製造方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021080411A Pending JP2021120396A (ja) | 2015-09-25 | 2021-05-11 | オナプリストン中間体の製造方法 |
Country Status (7)
Country | Link |
---|---|
US (1) | US10308676B2 (ja) |
EP (1) | EP3353148A4 (ja) |
JP (2) | JP2018528944A (ja) |
AU (1) | AU2016326657B2 (ja) |
BR (1) | BR112018005999A2 (ja) |
CA (1) | CA2998924A1 (ja) |
WO (1) | WO2017053793A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021120396A (ja) * | 2015-09-25 | 2021-08-19 | コンテクスト バイオファーマ インコーポレイテッド | オナプリストン中間体の製造方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2966753A1 (en) | 2014-11-17 | 2016-05-26 | Arno Therapeutics, Inc. | Onapristone extended-release compositions and methods |
US10548905B2 (en) | 2015-12-15 | 2020-02-04 | Context Biopharma Inc. | Amorphous onapristone compositions and methods of making the same |
US20180148471A1 (en) | 2016-11-30 | 2018-05-31 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
WO2023000135A1 (en) * | 2021-07-19 | 2023-01-26 | Context Biopharma Inc. | Processes of making onapristone and intermediates thereof |
Citations (3)
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JPS6041695A (ja) * | 1983-06-15 | 1985-03-05 | シエ−リング・アクチエンゲゼルシヤフト | 13α−アルキルゴナン、その製造方法及び該化合物を含有する、抗ゲスタ−ゲン作用を有する製剤製品 |
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-
2016
- 2016-09-23 WO PCT/US2016/053435 patent/WO2017053793A1/en active Application Filing
- 2016-09-23 JP JP2018509611A patent/JP2018528944A/ja active Pending
- 2016-09-23 CA CA2998924A patent/CA2998924A1/en active Pending
- 2016-09-23 BR BR112018005999A patent/BR112018005999A2/pt not_active Application Discontinuation
- 2016-09-23 AU AU2016326657A patent/AU2016326657B2/en not_active Ceased
- 2016-09-23 US US15/274,555 patent/US10308676B2/en active Active
- 2016-09-23 EP EP16849747.7A patent/EP3353148A4/en not_active Withdrawn
-
2021
- 2021-05-11 JP JP2021080411A patent/JP2021120396A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6041695A (ja) * | 1983-06-15 | 1985-03-05 | シエ−リング・アクチエンゲゼルシヤフト | 13α−アルキルゴナン、その製造方法及び該化合物を含有する、抗ゲスタ−ゲン作用を有する製剤製品 |
JP2004528882A (ja) * | 2001-03-13 | 2004-09-24 | トライトン・サラシック・テクノロジーズ・インコーポレイテッド | 単色液体処理システム |
WO2008128783A2 (en) * | 2007-04-24 | 2008-10-30 | Dsm Ip Assets B.V. | Photochemical process for the preparation of a previtamin d |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021120396A (ja) * | 2015-09-25 | 2021-08-19 | コンテクスト バイオファーマ インコーポレイテッド | オナプリストン中間体の製造方法 |
Also Published As
Publication number | Publication date |
---|---|
CA2998924A1 (en) | 2017-03-30 |
EP3353148A1 (en) | 2018-08-01 |
BR112018005999A2 (pt) | 2019-01-08 |
EP3353148A4 (en) | 2019-04-24 |
AU2016326657A1 (en) | 2018-03-08 |
US20170088579A1 (en) | 2017-03-30 |
JP2021120396A (ja) | 2021-08-19 |
WO2017053793A1 (en) | 2017-03-30 |
AU2016326657B2 (en) | 2019-10-24 |
US10308676B2 (en) | 2019-06-04 |
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