JP2017536816A - 非プロトン化型およびプロトン化型のニコチンを含む溶液 - Google Patents
非プロトン化型およびプロトン化型のニコチンを含む溶液 Download PDFInfo
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- JP2017536816A JP2017536816A JP2017523309A JP2017523309A JP2017536816A JP 2017536816 A JP2017536816 A JP 2017536816A JP 2017523309 A JP2017523309 A JP 2017523309A JP 2017523309 A JP2017523309 A JP 2017523309A JP 2017536816 A JP2017536816 A JP 2017536816A
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- A24B15/18—Treatment of tobacco products or tobacco substitutes
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- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
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-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
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- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
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- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
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- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
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- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
Description
(i)担体、
(ii)非プロトン化型およびプロトン化型のニコチン、および
(iii)少なくとも安息香酸、レブリン酸またはそれらの混合物が存在する1種以上の酸を含むニコチン溶液であって、かつ前記溶液中に存在する酸の総含有量は、ニコチンに対して0.6モル当量以下である、ニコチン溶液を提供する。
(a)容器、および
(b)ニコチン溶液を含み、前記ニコチン溶液は
(i)担体、
(ii)非プロトン化型およびプロトン化型のニコチン、および
(iii)少なくとも安息香酸、レブリン酸またはそれらの混合物が存在する1種以上の酸を含み、かつ前記溶液中に存在する酸の総含有量は、ニコチンに対して0.6モル当量以下である、容器に入れられたニコチン溶液を提供する。
電子蒸気供給システムの使用者が吸入するための液体を気化させる気化器、
気化器に電力を供給するための電池を含む電源、および
ニコチン溶液を含み、前記ニコチン溶液は
(i)担体、
(ii)非プロトン化およびプロトン化型のニコチン、および
(iii)少なくとも安息香酸、レブリン酸またはそれらの混合物が存在する1種以上の酸を含み、かつ前記溶液中に存在する酸の総含有量は、ニコチンに対して0.6モル当量以下である電子蒸気供給システムを提供する。
(a)ニコチン溶液を用意する工程、および
(b)前記ニコチン溶液を気化させる工程
を含み、前記ニコチン溶液は、
(i)担体、
(ii)非プロトン化型およびプロトン化型のニコチン、および
(iii)少なくとも安息香酸、レブリン酸またはそれらの混合物が存在する1種以上の酸を含み、かつ前記溶液中に存在する酸の総含有量は、ニコチンに対して0.6モル当量以下である、気化したニコチン溶液の感覚特性を改善する方法を提供する。
(i)担体、
(ii)非プロトン化型およびプロトン化型のニコチン、および
(iii)1種以上の酸(少なくとも安息香酸、レブリン酸またはそれらの混合物が存在する)を含み、前記溶液中に存在する酸の総含有量は、ニコチンに対して0.6モル当量以下である、気化したニコチン溶液の感覚特性を改善するための1種以上の酸の使用が提供される。
(i)担体、
(ii)非プロトン化型およびプロトン化型のニコチン、
(iii)安息香酸、レブリン酸およびそれらの混合物から選択される第1の酸、および
(iv)存在する場合には、安息香酸、レブリン酸およびそれらの混合物以外の酸から選択される、任意に存在する第2の酸を含むニコチン溶液を提供する。前記溶液中に存在する第1の酸と第2の酸の合計含有量はニコチンに対して0.6モル当量以下である。
(i)担体、
(ii)プロトン化型および非プロトン化型のニコチン、および
(iii)安息香酸
を含むニコチン溶液を提供する。
(a)ニコチン溶液を提供する工程であって、前記ニコチン溶液は
(i)担体、および
(ii)非プロトン化型のニコチン
を含むニコチン溶液を用意するする工程、
(b)1種以上の酸(少なくとも安息香酸、レブリン酸またはその混合物が存在する)を含む酸溶液を用意する工程、
(c)前記ニコチン溶液および前記酸溶液を気化させる工程、および
(d)前記ニコチンに対して0.6モル当量以下の量で酸が存在するように、前記気化したニコチン溶液と前記気化した酸溶液とを混合する工程を含む、気化したニコチン溶液の感覚特性を改善する方法も提供される。
従って、更なる態様において、本発明は、
電子蒸気供給システムの使用者が吸入するための液体を気化させる気化器、
気化器に電力を供給するための電池を含む電源、および
ニコチン溶液を含み、前記ニコチン溶液は
(i)担体、
(ii)非プロトン化およびプロトン化型のニコチン、および
(iii)1種以上の酸(少なくとも安息香酸、レブリン酸またはそれらの混合物が存在する)を含み、前記溶液中に存在する酸の総含有量は、ニコチンに対して0.6モル当量以下である電子蒸気供給システムを提供する。
グリセリン/水系におけるニコチンのpKa値の測定は、“Spectroscopic investigations into the acid-base properties of nicotine at different temperatures(種々の温度におけるニコチンの酸−塩基特性に関する分光学的研究)”, Peter M. Clayton、Carl A. Vas, Tam TT Bui, Alex F. Drake and Kevin McAdam, Anal. Methods, 2013, 5, 81−88に記載された基本的な手法を用いて実施し、以下に要約した。系が主に非水性であるので、パラメータpsKa2を測定した。ここで、添え字sは溶媒組成がこのほぼ非水性系であることを指し、下付き文字2はピロリジル窒素のpKa値を指す。
Claims (24)
- (i)担体、
(ii)非プロトン化型およびプロトン化型のニコチン、および
(iii)少なくとも安息香酸、レブリン酸またはそれらの混合物が存在する1種以上の酸を含むニコチン溶液であって、かつ前記溶液中に存在する酸の総含有量はニコチンに対して0.6モル当量以下である、ニコチン溶液。 - 更に水を含むことを特徴とする請求項1に記載のニコチン溶液。
- 少なくとも安息香酸が存在することを特徴とする請求項1または2に記載のニコチン溶液。
- 安息香酸からなる群から選択される酸を含有することを特徴とする請求項1乃至3のいずれか1項に記載のニコチン溶液。
- レブリン酸からなる群から選択される酸を含有することを特徴とする請求項1乃至3のいずれか1項に記載のニコチン溶液。
- 前記溶液中に存在する酸の総含有量は前記ニコチンに対して0.5モル当量以下であることを特徴とする請求項1乃至5のいずれか1項に記載のニコチン溶液。
- 前記溶液中に存在する酸の総含有量は前記ニコチンに対して0.2モル当量以上であることを特徴とする請求項1乃至6のいずれか1項に記載のニコチン溶液。
- 前記溶液中に存在する安息香酸の量は前記ニコチンに対して0.2モル当量以上であることを特徴とする請求項1乃至7のいずれか1項に記載のニコチン溶液。
- 前記溶液中に存在する安息香酸とレブリン酸の合計量は前記ニコチンに対して0.2〜0.4モル当量であることを特徴とする請求項1乃至8のいずれか1項に記載のニコチン溶液。
- 前記溶液中に存在する安息香酸の量はニコチンに対して0.2〜0.4モル当量であることを特徴とする請求項1乃至9のいずれか1項に記載のニコチン溶液。
- ニコチンを前記溶液の総重量に対して2重量%以下の量で含むことを特徴とする請求項1乃至10のいずれか1項に記載のニコチン溶液。
- 前記溶液の総重量に対して1.8重量%以下の量のニコチンを含むことを特徴とする請求項1乃至10のいずれか1項に記載のニコチン溶液。
- レブリン酸からなる群から選択される酸を含有し、ニコチンを前記溶液の総重量に対して1.8重量%以下の量で含むことを特徴とする請求項1乃至12のいずれか1項に記載のニコチン溶液。
- 前記担体は溶媒であることを特徴とする請求項1乃至13のいずれか1項に記載のニコチン溶液。
- 前記溶媒はグリセリン、プロピレングリコールおよびそれらの混合物から選択されることを特徴とする請求項14に記載のニコチン溶液。
- (a)容器、および
(b)ニコチン溶液
を含み、前記ニコチン溶液は
(i)担体、
(ii)非プロトン化型およびプロトン化型のニコチン、および
(iii)少なくとも安息香酸、レブリン酸またはそれらの混合物が存在する1種以上の酸を含み、かつ前記溶液中に存在する酸の総含有量は、ニコチンに対して0.6モル当量以下である、容器に入れられたニコチン溶液。 - 前記ニコチン溶液は水を更に含むことを特徴とする請求項16に記載の容器に入れられたニコチン溶液。
- 前記容器は電子蒸気供給システムと係合するように構成されていることを特徴とする請求項17に記載の容器に入れられたニコチン溶液。
- 前記ニコチン溶液は請求項2乃至15のいずれか1項に定義されていることを特徴とする請求項16乃至18のいずれか1項に記載の容器に入れられたニコチン溶液。
- 電子蒸気供給システムの使用者が吸入するための液体を気化させる気化器、
気化器に電力を供給するための電池を含む電源、および
ニコチン溶液を含み、前記ニコチン溶液は
(i)担体、
(ii)非プロトン化およびプロトン化型のニコチン、および
(iii)少なくとも安息香酸、レブリン酸またはそれらの混合物が存在する1種以上の酸を含み、かつ前記溶液中に存在する酸の総含有量は、ニコチンに対して0.6モル当量以下である、電子蒸気供給システム。 - 前記ニコチン溶液は請求項2乃至15のいずれか1項に定義されていることを特徴とする請求項20に記載の電子蒸気供給システム。
- (a)ニコチン溶液を用意する工程、および
(b)前記ニコチン溶液を気化させる工程
を含み、前記ニコチン溶液は
(i)担体、
(ii)非プロトン化型およびプロトン化型のニコチン、および
(iii)少なくとも安息香酸、レブリン酸またはそれらの混合物が存在する1種以上の酸を含み、かつ前記溶液中に存在する酸の総含有量がニコチンに対して0.6モル当量以下である、気化したニコチン溶液の感覚特性を改善する方法。 - 前記ニコチン溶液は請求項2乃至14のいずれか1項に定義されていることを特徴とする請求項22に記載の方法。
- (i)担体、
(ii)非プロトン化型およびプロトン化型のニコチン、および
(iii)少なくとも安息香酸、レブリン酸またはそれらの混合物が存在する1種以上の酸を含み、かつ前記溶液中に存在する酸の総含有量は、ニコチンに対して0.6モル当量以下である、気化したニコチン溶液の感覚特性を改善するための1種以上の酸の使用。
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WO2020161798A1 (ja) * | 2019-02-05 | 2020-08-13 | 日本たばこ産業株式会社 | 液体加熱式の加熱型香味吸引器用の液体組成物 |
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